Detailed information for compound 800383

Basic information

Technical information
  • TDR Targets ID: 800383
  • Name: 4-amino-2H-pyrazole-3-carboxamide
  • MW: 126.117 | Formula: C4H6N4O
  • H donors: 3 H acceptors: 2 LogP: -0.7 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)c1n[nH]cc1N
  • InChi: 1S/C4H6N4O/c5-2-1-7-8-3(2)4(6)9/h1H,5H2,(H2,6,9)(H,7,8)
  • InChiKey: JVXDFTZWKFHULK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Pyrazole-5-carboxamide, 4-amino-
  • ZERO/003108
  • ZINC01072662
  • Oprea1_165018

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.041 0.0928
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0812 0.4329 0.4326
Leishmania major DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Plasmodium vivax glutathione reductase, putative 0.0139 0.0657 0.1611
Toxoplasma gondii CBS domain-containing protein 0.0048 0.0163 0.0371
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0077 0.0318 0.2147
Loa Loa (eye worm) hypothetical protein 0.024 0.1207 0.2784
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative 0.002 0.001 0.0016
Giardia lamblia Hypothetical protein 0.002 0.001 0.0032
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0237 0.0533
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0021
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0044 0.0039
Leishmania major myo-inositol-1 phosphatase, putative 0.002 0.001 0.0016
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0056 0.0123
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0191 0.0943 0.6514
Brugia malayi beta-lactamase 0.029 0.1481 0.3417
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0004 0.0002
Mycobacterium tuberculosis Conserved protein 0.029 0.1481 0.1477
Echinococcus granulosus neutral alpha glucosidase AB 0.0077 0.0318 0.0719
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0044 0.0094
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0077
Giardia lamblia PHD finger protein 15 0.0058 0.0218 0.1478
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.029 0.1481 0.1477
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0012 0.0021
Mycobacterium tuberculosis Conserved protein 0.0048 0.0163 0.0158
Trypanosoma cruzi chloride channel protein, putative 0.0048 0.0163 0.0371
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0163 0.0369
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.029 0.1481 0.3371
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0331 0.1704 0.3879
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0037 0.0078
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0223 0.051
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0318 0.2147
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0125
Schistosoma mansoni hypothetical protein 0.0034 0.0085 0.0187
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0812 0.4329 0.9864
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0077 0.0318 0.2173
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0021
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0171 0.0834 0.1908
Chlamydia trachomatis DNA topoisomerase I 0.0021 0.0015 0.0326
Echinococcus multilocularis GPCR, family 2 0.0034 0.0085 0.0187
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0016
Schistosoma mansoni hypothetical protein 0.0034 0.0085 0.0187
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0023 0.0047
Leishmania major DNA polymerase eta, putative 0.0019 0.0005 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0331 0.1704 0.3879
Brugia malayi follicle stimulating hormone receptor 0.0227 0.1137 0.2622
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0263 0.0594
Loa Loa (eye worm) hypothetical protein 0.0062 0.0237 0.0541
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.029 0.1481 0.3417
Mycobacterium ulcerans glutaminase 0.0265 0.1345 0.3099
Brugia malayi F/Y-rich N-terminus family protein 0.004 0.0116 0.0262
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0812 0.4329 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0056 0.0123
Leishmania major alpha glucosidase II subunit, putative 0.0077 0.0318 0.0728
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0144
Mycobacterium ulcerans transcriptional regulator 0.0048 0.0163 0.0366
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0044 0.2213
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0331 0.1704 0.3932
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0005 0.0005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0085 0.0187
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0191 0.0943 0.2173
Echinococcus granulosus jumonji domain containing protein 0.0081 0.0342 0.0774
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0085 0.019
Trypanosoma brucei GMP reductase 0.0812 0.4329 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1445 0.9757
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0331 0.1704 0.3932
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0048 0.0163 0.0364
Schistosoma mansoni hypothetical protein 0.0034 0.0085 0.0187
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0048 0.0163 0.0393
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0812 0.4329 1
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0048 0.0163 0.0356
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0427 0.2226 0.513
Brugia malayi TAR-binding protein 0.0067 0.0263 0.0602
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0126 0.0853
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.041 0.0928
Echinococcus granulosus beta LACTamase domain containing family member 0.029 0.1481 0.3371
Loa Loa (eye worm) hypothetical protein 0.029 0.1481 0.3417
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0163 0.0369
Echinococcus multilocularis lysosomal alpha glucosidase 0.0345 0.1783 0.4058
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.029 0.1481 0.3414
Loa Loa (eye worm) hypothetical protein 0.0073 0.0299 0.0685
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0191 0.0943 0.2173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0331 0.1704 0.3879
Schistosoma mansoni hypothetical protein 0.0034 0.0085 0.0187
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0345 0.1783 0.4114
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Brugia malayi beta-lactamase family protein 0.029 0.1481 0.3417
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0077 0.0318 0.0718
Leishmania major inositol polyphosphate 1-phosphatase, putative 0.002 0.001 0.0016
Mycobacterium ulcerans lipase LipD 0.029 0.1481 0.3414
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0812 0.4329 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0005 0.0005
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0237 0.0533
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0012 0.0021
Schistosoma mansoni ap endonuclease 0.0077 0.0318 0.0718
Trichomonas vaginalis maltase-glucoamylase, putative 0.0077 0.0318 0.2147
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0317 0.1627 0.1623
Schistosoma mansoni importin beta-1 0.0059 0.0223 0.0503
Echinococcus multilocularis SWI:SNF matrix associated 0.0021 0.0015 0.0027
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0004 0.0002
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0023 0.005
Loa Loa (eye worm) hypothetical protein 0.029 0.1481 0.3417
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0015
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0048 0.0163 0.0364
Schistosoma mansoni chloride channel protein 0.0048 0.0163 0.0366
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0016
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.009 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0012 0.0021
Loa Loa (eye worm) glutaminase 0.0265 0.1345 0.3103
Brugia malayi CBS domain containing protein 0.0048 0.0163 0.0371
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0048 0.0163 0.0279
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.0047
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1159 0.7827
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0655 0.065
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0048 0.0163 0.11
Mycobacterium tuberculosis Probable esterase LipL 0.029 0.1481 0.1477
Leishmania major glycosyl hydrolase-like protein 0.0029 0.0056 0.0123
Onchocerca volvulus 0.003 0.0065 0.032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0331 0.1704 0.3879
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0048 0.0163 0.0279
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.041 0.0941
Schistosoma mansoni rab6-interacting 0.0062 0.0237 0.0533
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0048 0.0163 0.0158
Leishmania major trypanothione reductase 0.0139 0.0657 0.1513
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0012 0.0021
Brugia malayi brahma associated protein 60 kDa 0.0021 0.0015 0.0027
Brugia malayi brahma associated protein 60 kDa 0.0021 0.0015 0.0027
Treponema pallidum hemolysin (tlyC) 0.0048 0.0163 0.0854
Loa Loa (eye worm) hypothetical protein 0.029 0.1481 0.3417
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0033 0.0223
Mycobacterium ulcerans hypothetical protein 0.029 0.1481 0.3414
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0023 0.005
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0162 0.0369
Loa Loa (eye worm) hypothetical protein 0.0039 0.0115 0.026
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0263 0.0602
Schistosoma mansoni inositol monophosphatase 0.0191 0.0943 0.2144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Onchocerca volvulus 0.0048 0.0163 0.0888
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0048 0.0163 0.0369
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0239 0.1202 0.2733
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0012 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1445 0.9757
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0036 0.0077
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0048 0.0163 0.0366
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0263 0.0594
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0048 0.0163 0.0158
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.0047
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0155 0.0347
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0218 0.049
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0021
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0191 0.0943 0.217
Echinococcus granulosus H:Cl exchange transporter 3 0.0048 0.0163 0.0366
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0048 0.0163 0.0366
Mycobacterium tuberculosis Probable dehydrogenase 0.0317 0.1627 0.1623
Mycobacterium tuberculosis Probable monophosphatase 0.002 0.001 0.0005
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0338 0.1741 0.4017
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0036 0.0082
Loa Loa (eye worm) hypothetical protein 0.0037 0.0103 0.0231
Loa Loa (eye worm) hypothetical protein 0.0039 0.011 0.0249
Plasmodium falciparum thioredoxin reductase 0.0139 0.0657 0.1611
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0263 0.0594
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.019
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0048 0.0163 0.11
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0484 0.1112
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0012 0.0021
Loa Loa (eye worm) beta-lactamase 0.029 0.1481 0.3417
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0352 0.182 0.1816
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0012 0.0021
Brugia malayi Pre-SET motif family protein 0.003 0.0065 0.0144
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.0318 0.0776
Toxoplasma gondii CBS family protein 0.0048 0.0163 0.0371
Plasmodium vivax multidomain scavenger receptor, putative 0.0062 0.0237 0.0576
Brugia malayi glutathione reductase 0.0139 0.0657 0.1513
Schistosoma mansoni hypothetical protein 0.0692 0.3672 0.8365
Echinococcus granulosus cpg binding protein 0.0063 0.0244 0.0549
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0036 0.0077
Onchocerca volvulus 0.029 0.1481 0.85
Brugia malayi ancient conserved domain protein 4 0.0048 0.0163 0.0371
Mycobacterium ulcerans hypothetical protein 0.0048 0.0163 0.0366
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0005 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0318 0.0728
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0318 0.2147
Onchocerca volvulus 0.0049 0.0167 0.0908
Mycobacterium leprae Probable lipase LipE 0.029 0.1481 0.3407
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0077 0.0318 0.2173
Trypanosoma brucei hypothetical protein, conserved 0.029 0.1481 0.3417
Trichomonas vaginalis myo inositol monophosphatase, putative 0.002 0.001 0.0065
Brugia malayi steroid hormone receptor 0.002 0.0012 0.0021
Loa Loa (eye worm) hypothetical protein 0.0068 0.0274 0.0626
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.041 0.0928
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0012 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.029 0.1481 1
Onchocerca volvulus 0.029 0.1481 0.85
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0012 0.0021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0484 0.1112
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0056 0.0378
Echinococcus granulosus tumor protein p63 0.0357 0.1847 0.4204
Loa Loa (eye worm) GMP reductase 0.0338 0.1741 0.4017
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0023 0.0046
Plasmodium falciparum importin beta, putative 0.0059 0.0223 0.0543
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0012 0.0021
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0352 0.182 0.419
Loa Loa (eye worm) glutaminase 2 0.0265 0.1345 0.3103
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0516 0.1185
Schistosoma mansoni alpha-glucosidase 0.0297 0.152 0.346
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0012 0.0021
Leishmania major hypothetical protein, conserved 0.0048 0.0163 0.0371
Toxoplasma gondii CBS domain-containing protein 0.0048 0.0163 0.0371
Echinococcus multilocularis beta LACTamase domain containing family member 0.029 0.1481 0.3371
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Mycobacterium ulcerans hypothetical protein 0.0048 0.0163 0.0366
Echinococcus granulosus lipoxygenase domain containing protein 0.0062 0.0237 0.0533
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0048 0.0163 0.0369
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0263 0.0602
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.0556 0.1279
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0056 0.0378
Brugia malayi hypothetical protein 0.0062 0.0237 0.0541
Schistosoma mansoni hypothetical protein 0.0021 0.0015 0.0027
Plasmodium vivax SET domain protein, putative 0.003 0.0065 0.0153
Schistosoma mansoni lipoxygenase 0.0128 0.0596 0.1353
Brugia malayi chromobox protein homolog 3 0.0039 0.011 0.0249
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0077 0.0318 0.0728
Mycobacterium ulcerans inositol-monophosphatase ImpA 0.002 0.001 0.0011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0085 0.0187
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0085 0.019
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0233 0.0525
Loa Loa (eye worm) hypothetical protein 0.0048 0.0163 0.0371
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0085 0.019
Brugia malayi AF-10 protein 0.0019 0.0004 0.0003
Echinococcus granulosus SWI:SNF matrix associated 0.0021 0.0015 0.0027
Plasmodium falciparum phd finger protein, putative 0.0058 0.0218 0.0529
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0812 0.4329 0.9864
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0012 0.0021
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0048 0.0163 0.0158
Trypanosoma brucei unspecified product 0.0019 0.0005 0.0005
Trichomonas vaginalis penicillin-binding protein, putative 0.029 0.1481 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0162 0.1096
Brugia malayi PHD-finger family protein 0.0024 0.0032 0.0068
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0338 0.1741 0.4017
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0048 0.0163 0.0365
Trichomonas vaginalis mercuric reductase, putative 0.0048 0.0163 0.1098
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0012 0.0021
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0764 0.4066 0.9392
Schistosoma mansoni survival motor neuron protein 0.0049 0.0167 0.0374
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0313 0.0707
Schistosoma mansoni thyroid hormone receptor 0.002 0.0012 0.0021
Brugia malayi Pre-SET motif family protein 0.0203 0.1007 0.2322
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0163 0.0369
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0048 0.0163 0.0365
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0048 0.0163 0.0366
Echinococcus multilocularis RUN 0.0062 0.0237 0.0533
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0048 0.0163 0.9955
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0012 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0012 0.0021
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0023 0.0023 0.005
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0048 0.0163 0.0365
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1007 0.2322
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0004 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0049 0.0331
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0021
Onchocerca volvulus 0.0093 0.041 0.2312
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0048 0.0163 0.0369
Trypanosoma cruzi hypothetical protein, conserved 0.029 0.1481 0.3417
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0005 0.0005
Mycobacterium tuberculosis Probable lipase LipD 0.029 0.1481 0.1477
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0263 0.0594
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0005 0.0005
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0048 0.0163 0.0371
Trypanosoma brucei trypanothione reductase 0.0139 0.0657 0.1513
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0012 0.0014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0012 0.0021
Plasmodium falciparum glutathione reductase 0.0139 0.0657 0.1611
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0048 0.0163 0.0371
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0155 0.0347
Leishmania major chloride channel protein, putative 0.0048 0.0163 0.0371
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0044 0.0089
Chlamydia trachomatis CBS domain-containing protein 0.0048 0.0163 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0004 0.0003
Brugia malayi beta-lactamase family protein 0.029 0.1481 0.3417
Mycobacterium tuberculosis Probable lipase LipE 0.029 0.1481 0.1477
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0005 0.0005
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0812 0.4329 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0218 0.0497
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0331 0.1704 0.3879
Brugia malayi chloride channel protein 7 0.0048 0.0163 0.0371
Echinococcus granulosus thioredoxin glutathione reductase 0.0139 0.066 0.1498
Echinococcus granulosus peregrin 0.0061 0.023 0.0519
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0012 0.0021
Plasmodium falciparum LCCL domain-containing protein 0.0062 0.0237 0.0576
Onchocerca volvulus 0.0041 0.0126 0.0674
Trichomonas vaginalis penicillin-binding protein, putative 0.029 0.1481 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative 0.002 0.001 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0005 0.0005
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0048 0.0163 0.0369
Schistosoma mansoni ap endonuclease 0.0077 0.0318 0.0718
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0005 0.0005
Mycobacterium tuberculosis Conserved protein 0.029 0.1481 0.1477
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0021 0.0015 0.0027
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0044 0.01
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0386 0.2004 0.4617
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0275 0.0629
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0048 0.0163 0.0371
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0004 0.0003
Schistosoma mansoni rab6-interacting 0.0062 0.0237 0.0533
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0048 0.0163 0.0393
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Brugia malayi Inositol-1 0.0191 0.0943 0.2173
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0191 0.0943 0.2173
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0065 0.0142
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1445 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0077 0.0318 0.1957
Schistosoma mansoni hypothetical protein 0.0019 0.0004 0.0003
Leishmania major inosine-5-monophosphate dehydrogenase 0.0812 0.4329 1
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0764 0.4066 1
Trypanosoma brucei inositol polyphosphate 1-phosphatase, putative 0.002 0.001 0.0016
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0048 0.0163 0.0278
Loa Loa (eye worm) hypothetical protein 0.0093 0.041 0.0941
Loa Loa (eye worm) hypothetical protein 0.0062 0.0237 0.0541
Trichomonas vaginalis inositol monophosphatase, putative 0.002 0.001 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0012 0.0021
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0036 0.0082
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0056 0.0354
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0812 0.4329 1
Brugia malayi Bromodomain containing protein 0.0076 0.0314 0.0719
Schistosoma mansoni glutaminase 0.0265 0.1345 0.3061
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0048 0.0163 0.0369
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0812 0.4329 1
Schistosoma mansoni polycystin 1-related 0.0062 0.0237 0.0533
Brugia malayi loechrig isoform VII 0.0048 0.0163 0.0371
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0275 0.1857
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0386 0.2004 0.4623
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0012 0.0014
Plasmodium vivax hypothetical protein, conserved 0.029 0.1481 0.3638
Loa Loa (eye worm) glutathione reductase 0.0139 0.0657 0.1513
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0077 0.0318 0.0724
Mycobacterium tuberculosis Probable hydrolase 0.029 0.1481 0.1477
Schistosoma mansoni hypothetical protein 0.0021 0.0015 0.0027
Brugia malayi GMP reductase 0.0338 0.1741 0.4017
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0655 0.1494
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0012 0.0021
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0023 0.0046
Loa Loa (eye worm) hypothetical protein 0.0048 0.0163 0.0371
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0048 0.0163 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0015 0.0099
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0048 0.0163 0.0369
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0048 0.0163 0.0366
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0218 0.0497
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0077 0.0318 0.0728
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.011 0.0745
Echinococcus multilocularis snurportin 1 0.0633 0.3349 0.763
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0012 0.0021
Trichomonas vaginalis inositol monophosphatase, putative 0.002 0.001 0.0065
Mycobacterium tuberculosis Probable reductase 0.0317 0.1627 0.1623
Mycobacterium tuberculosis Conserved protein 0.029 0.1481 0.1477
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0163 0.0369
Onchocerca volvulus 0.0021 0.0015 0.0029
Trichomonas vaginalis glutathione reductase, putative 0.0048 0.0163 0.1098
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0163 0.0369
Brugia malayi Doublecortin family protein 0.0062 0.0237 0.0541
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0331 0.1704 0.3879
Brugia malayi nuclear hormone receptor 0.002 0.0012 0.0021
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.1445 1
Echinococcus multilocularis geminin 0.0692 0.3672 0.8365
Loa Loa (eye worm) hypothetical protein 0.01 0.0445 0.1021
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0048 0.0163 0.0158
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0162 0.1096
Echinococcus multilocularis neutral alpha glucosidase AB 0.0077 0.0318 0.0719
Schistosoma mansoni nuclear hormone receptor 0.002 0.0012 0.0021
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0633 0.3349 0.7735
Entamoeba histolytica hypothetical protein 0.0048 0.0162 0.1092
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0191 0.094 0.2138
Loa Loa (eye worm) hypothetical protein 0.0107 0.0484 0.1112
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1445 0.9757
Echinococcus granulosus H:Cl exchange transporter 7 0.0048 0.0163 0.0366
Brugia malayi Inositol monophosphatase family protein 0.002 0.001 0.0016
Brugia malayi SWIB/MDM2 domain containing protein 0.0021 0.0015 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.011 0.0745
Echinococcus granulosus lysine specific demethylase 5A 0.0076 0.0313 0.0707
Loa Loa (eye worm) loechrig isoform VII 0.0048 0.0163 0.0371
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0318 0.2147
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0317 0.1627 0.3744
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0012 0.0021
Onchocerca volvulus Putative GMP reductase 0.0338 0.1741 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0012 0.0021
Mycobacterium tuberculosis Conserved protein 0.0048 0.0163 0.0158
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0048 0.0163 0.0366
Giardia lamblia Hypothetical protein 0.0048 0.0163 0.11
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.0318 0.2147
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0012 0.0021
Schistosoma mansoni brg-1 associated factor 0.0021 0.0015 0.0027
Toxoplasma gondii NADPH-glutathione reductase 0.0048 0.0163 0.0369
Brugia malayi Importin beta-1 subunit 0.0059 0.0223 0.051
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0044 0.0094
Echinococcus granulosus geminin 0.0692 0.3672 0.8365
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.1137 0.2622
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0021 0.0015 0.0029
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0044 0.0089
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0163 0.0369
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0021
Toxoplasma gondii IMP dehydrogenas 0.0812 0.4329 1
Plasmodium falciparum glutathione reductase 0.0048 0.0163 0.0393
Schistosoma mansoni bromodomain containing protein 0.0065 0.0252 0.0569
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0012 0.0021
Brugia malayi Bromodomain containing protein 0.0061 0.023 0.0526
Leishmania major GTP-binding protein, putative 0.0022 0.0023 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.029 0.1481 1
Treponema pallidum Mg2+ transport protein (mgtE) 0.0048 0.0163 0.0854
Echinococcus granulosus zinc finger protein 0.0022 0.0022 0.0043
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0048 0.0163 0.0366
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0331 0.1704 0.3879
Echinococcus granulosus survival motor neuron protein 1 0.024 0.1207 0.2746
Echinococcus multilocularis inositol monophosphatase 0.002 0.001 0.0015
Echinococcus multilocularis SWI:SNF matrix associated 0.0021 0.0015 0.0027
Loa Loa (eye worm) brahma associated protein 0.0021 0.0015 0.0027
Echinococcus granulosus importin subunit beta 1 0.0059 0.0223 0.0503
Onchocerca volvulus 0.0062 0.0237 0.1312
Loa Loa (eye worm) hypothetical protein 0.029 0.1481 0.3417
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0077 0.0318 0.0313
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0812 0.4329 1
Brugia malayi glutaminase DH11.1 0.0265 0.1345 0.3103
Loa Loa (eye worm) inositol-1 0.0191 0.0943 0.2173
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.0047
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0223 0.051
Echinococcus granulosus RUN 0.0062 0.0237 0.0533
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0033 0.0223
Onchocerca volvulus 0.002 0.0012 0.0014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0012 0.0021
Plasmodium falciparum thioredoxin reductase 0.0048 0.0163 0.0393
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0005 0.0005
Trypanosoma brucei glycosyl hydrolase-like protein 0.0029 0.0056 0.0123
Trypanosoma cruzi GMP reductase 0.0812 0.4329 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0077 0.0318 0.2147
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0012 0.0021
Brugia malayi Thioredoxin reductase 0.0139 0.0657 0.1513
Loa Loa (eye worm) hypothetical protein 0.0059 0.0223 0.051
Trypanosoma cruzi trypanothione reductase, putative 0.0139 0.0657 0.1513
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0191 0.0943 0.2099
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0216 0.0492
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0021 0.0015 0.0027
Trichomonas vaginalis sucrase-isomaltase, putative 0.0077 0.0318 0.2147
Echinococcus granulosus tar DNA binding protein 0.0067 0.0263 0.0594
Schistosoma mansoni alpha glucosidase 0.0077 0.0318 0.0719
Schistosoma mansoni thyroid hormone receptor 0.002 0.0012 0.0021
Toxoplasma gondii hypothetical protein 0.002 0.001 0.0016
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0048 0.0163 0.0364
Mycobacterium leprae conserved hypothetical protein 0.029 0.1481 0.3407
Loa Loa (eye worm) hypothetical protein 0.0047 0.0155 0.0352
Echinococcus multilocularis inositol monophosphatase 1 0.0191 0.0943 0.2144
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0029 0.0056 0.0123
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0085 0.0187
Schistosoma mansoni chromobox protein 0.0069 0.0275 0.0621
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.002 0.001 0.0065
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0427 0.2226 0.2222
Leishmania major importin beta-1 subunit, putative 0.0048 0.0162 0.0369
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Leishmania major hypothetical protein, conserved 0.0025 0.0036 0.0077
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0218 0.049
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0077 0.0318 0.2173
Echinococcus granulosus dna polymerase eta 0.0019 0.0005 0.0005
Schistosoma mansoni jumonji domain containing protein 0.0152 0.0727 0.165
Brugia malayi jmjC domain containing protein 0.0076 0.0313 0.0716
Trichomonas vaginalis maltase-glucoamylase, putative 0.0029 0.0056 0.0378
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0812 0.4329 0.9864
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0263 0.0594
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0048 0.0163 0.0393
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0191 0.0943 0.2173
Trypanosoma brucei glucosidase, putative 0.0077 0.0318 0.0728
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.029 0.1481 0.3371
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0048 0.0163 0.0366
Brugia malayi RNA, U transporter 1 0.0169 0.0819 0.1887
Mycobacterium ulcerans hypothetical protein 0.0048 0.0163 0.0366
Echinococcus multilocularis cpg binding protein 0.0063 0.0244 0.0549
Echinococcus granulosus GPCR family 2 0.0034 0.0085 0.0187
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.0342 0.0774
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0048 0.0163 0.0371
Mycobacterium ulcerans esterase/lipase LipP 0.029 0.1481 0.3414
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0263 0.0602
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0012 0.0021
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.009 0.0199
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1445 0.9757
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0047
Brugia malayi nuclear receptor NHR-88 0.002 0.0012 0.0021
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0812 0.4329 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0012 0.0021
Schistosoma mansoni hypothetical protein 0.002 0.0009 0.0015
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0239 0.1202 0.2733
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0031 0.0064
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0077 0.0318 0.0728
Trypanosoma cruzi chloride channel protein, putative 0.0048 0.0163 0.0371
Onchocerca volvulus 0.0058 0.0216 0.1189
Schistosoma mansoni hypothetical protein 0.0692 0.3672 0.8365
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0012 0.0021
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0048 0.0163 0.0366
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0191 0.0943 0.6368
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0012 0.0021
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0044 0.0094
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0077 0.0318 0.0728
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0012 0.0021
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0035 0.0093 0.0208
Schistosoma mansoni cpg binding protein 0.0063 0.0244 0.0549
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0033 0.0223
Loa Loa (eye worm) hypothetical protein 0.0058 0.0218 0.0497
Echinococcus multilocularis dnaJ subfamily B 0.0823 0.4389 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0077 0.0318 0.0728
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.005
Echinococcus granulosus dnaJ subfamily B 0.0823 0.4389 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0012 0.0021
Brugia malayi hypothetical protein 0.024 0.1207 0.2784
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0313 0.0707
Brugia malayi CXXC zinc finger family protein 0.0058 0.0216 0.0492
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0318 0.2147
Onchocerca volvulus 0.0231 0.1159 0.664
Echinococcus granulosus FTZ F1 alpha 0.002 0.0012 0.0021
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0155 0.0347
Chlamydia trachomatis Mg++ transporter 0.0048 0.0163 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0036 0.0077
Echinococcus multilocularis chromobox protein 1 0.0069 0.0275 0.0621
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.002 0.001 0.0015
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0077 0.0318 0.0718
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0077 0.0318 0.064
Trypanosoma cruzi hypothetical protein, conserved 0.029 0.1481 0.3417
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0191 0.0943 0.2173
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0085 0.0187
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0048 0.0163 0.0371
Loa Loa (eye worm) hypothetical protein 0.029 0.1481 0.3417
Trichomonas vaginalis ran, putative 0.0022 0.0023 0.0155
Schistosoma mansoni protein kinase subunit gamma 0.0048 0.0163 0.0366
Schistosoma mansoni hypothetical protein 0.0633 0.3349 0.763
Leishmania major guanosine monophosphate reductase 0.0812 0.4329 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0077 0.0318 0.0728
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0012 0.0021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0048 0.0163 0.0369
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1445 0.9757
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1445 0.9757
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0285 0.0643
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0012 0.0021
Loa Loa (eye worm) chloride channel 3 0.0048 0.0163 0.0371
Onchocerca volvulus Alhambra homolog 0.0058 0.0218 0.1203
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0035 0.0093 0.0208
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0317 0.1627 0.1623
Echinococcus multilocularis Polycystic kidney disease protein 0.0062 0.0237 0.0533
Toxoplasma gondii exonuclease III APE 0.0077 0.0318 0.0728
Schistosoma mansoni hypothetical protein 0.0049 0.0167 0.0374
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0056 0.0378
Echinococcus granulosus chromobox protein 1 0.0069 0.0275 0.0621
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0004 0.0002
Brugia malayi PHD-finger family protein 0.0027 0.005 0.0108
Echinococcus multilocularis chromobox protein 1 0.0069 0.0275 0.0621
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1445 0.9757
Giardia lamblia NADH oxidase lateral transfer candidate 0.0048 0.0163 0.1095
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0005 0.0005
Brugia malayi hypothetical protein 0.0025 0.0036 0.0077
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0048 0.0163 0.0369
Schistosoma mansoni pap-inositol-14-phosphatase 0.002 0.001 0.0015
Schistosoma mansoni coup transcription factor 0.002 0.0012 0.0021
Schistosoma mansoni alpha-glucosidase 0.0297 0.152 0.346
Toxoplasma gondii ABC1 family protein 0.029 0.1481 0.3417
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0015 0.0029
Mycobacterium tuberculosis Probable oxidoreductase 0.0352 0.182 0.1816
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0317 0.1627 0.1623
Trichomonas vaginalis esterase, putative 0.029 0.1481 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0012 0.0021
Toxoplasma gondii thioredoxin reductase 0.0139 0.0657 0.1513
Schistosoma mansoni hypothetical protein 0.0073 0.0299 0.0676
Echinococcus multilocularis tumor protein p63 0.0357 0.1847 0.4204
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0012 0.0021
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0044 0.0079
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0005 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.029 0.1481 0.3417
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0012 0.0021
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.002 0.001 0.0032
Brugia malayi ancient conserved domain protein 2 0.0048 0.0163 0.0371
Trichomonas vaginalis alpha-glucosidase, putative 0.0077 0.0318 0.2147
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0162 0.1096
Schistosoma mansoni cpg binding protein 0.0063 0.0244 0.0549
Echinococcus multilocularis lysosomal alpha glucosidase 0.0345 0.1783 0.4058
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0263 0.0594
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0005 0.0005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0012 0.0021
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0275 0.1857
Schistosoma mansoni hypothetical protein 0.0062 0.0237 0.0533
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0012 0.0021
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0313 0.0716
Mycobacterium ulcerans monophosphatase 0.002 0.001 0.0011
Loa Loa (eye worm) chloride channel protein 7 0.0048 0.0163 0.0371
Brugia malayi exodeoxyribonuclease III family protein 0.0077 0.0318 0.0728
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0048 0.0163 0.0158
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0048 0.0163 0.0369
Mycobacterium tuberculosis Monophosphatase CysQ 0.002 0.001 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0021
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0005 0.0005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0484 0.1112
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0021 0.0015 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Echinococcus granulosus snurportin 1 0.0633 0.3349 0.763
Trypanosoma cruzi chloride channel protein, putative 0.0048 0.0163 0.0371
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0047
Brugia malayi Bromodomain containing protein 0.0037 0.0102 0.023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0088 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0012 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0012 0.0021
Schistosoma mansoni cpg binding protein 0.0058 0.0216 0.0485
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0163 0.0356
Entamoeba histolytica Ran family GTPase 0.0022 0.0023 0.0125
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0065 0.0142
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0218 0.049
Entamoeba histolytica hypothetical protein 0.0026 0.0044 0.0268
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0021 0.0015 0.0029
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0191 0.094 0.2138
Schistosoma mansoni chloride channel protein 0.0048 0.0163 0.0366
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0223 0.0503
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0352 0.182 0.1816
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0021 0.0015 0.0027
Echinococcus granulosus inositol monophosphatase 0.002 0.001 0.0015
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0036 0.0077
Leishmania major hypothetical protein, conserved 0.029 0.1481 0.3417
Trypanosoma cruzi GMP reductase 0.0812 0.4329 1
Trichomonas vaginalis D-aminoacylase, putative 0.029 0.1481 1
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0048 0.0163 0.0279
Echinococcus granulosus chromobox protein 1 0.0069 0.0275 0.0621
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1445 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0077 0.0318 0.0728
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0318 0.0728
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0803 0.4279 0.975
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0233 0.0525
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0218 0.0497
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0005 0.0034
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.1207 0.2746
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0056 0.0378
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0048 0.0163 0.0366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0012 0.0021
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0048 0.0163 0.11
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0037 0.0078
Schistosoma mansoni myo inositol monophosphatase 0.002 0.001 0.0015
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0317 0.1627 0.1623
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0033 0.0223
Echinococcus granulosus H:Cl exchange transporter 4 0.0048 0.0163 0.0366
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0052 0.0113
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0048 0.0163 0.0278
Mycobacterium ulcerans cystathionine beta-synthase 0.0048 0.0163 0.0366
Schistosoma mansoni hypothetical protein 0.0058 0.0218 0.049
Echinococcus granulosus inositol monophosphatase 1 0.0191 0.0943 0.2144
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0029 0.0056 0.0267
Onchocerca volvulus 0.02 0.0989 0.5657
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0191 0.0943 0.6368
Echinococcus multilocularis peregrin 0.0061 0.023 0.0519
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0048 0.0163 0.0366
Schistosoma mansoni chromobox protein 0.0069 0.0275 0.0621
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.0575 0.1304
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0048 0.0163 0.0158
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0048 0.0163 0.0366
Mycobacterium ulcerans monophosphatase CysQ 0.002 0.001 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0155 0.0347
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0139 0.0657 0.0653
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0065 0.0144
Brugia malayi hypothetical protein 0.0062 0.0237 0.0541
Brugia malayi Voltage gated chloride channel family protein 0.0048 0.0163 0.0371
Brugia malayi Inositol monophosphatase family protein 0.002 0.001 0.0016
Mycobacterium tuberculosis Conserved protein 0.0048 0.0163 0.0158
Schistosoma mansoni chloride channel protein 0.0048 0.0163 0.0366
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1445 0.9757
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.0318 0.2147
Trichomonas vaginalis glutaminase, putative 0.0265 0.1345 0.9082
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0012 0.0021
Mycobacterium ulcerans monophosphatase CysQ 0.002 0.001 0.0011
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0005 0.0005
Plasmodium vivax thioredoxin reductase, putative 0.0139 0.0657 0.1611
Schistosoma mansoni DNA polymerase eta 0.0019 0.0005 0.0005
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0048 0.0163 0.0371
Plasmodium vivax importin-beta 2, putative 0.0059 0.0223 0.0543
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.029 0.1481 0.1477
Brugia malayi Heterochromatin protein 1 0.0069 0.0275 0.0629
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.011 0.0582
Brugia malayi Glycosyl hydrolases family 31 protein 0.0345 0.1783 0.4114
Loa Loa (eye worm) hypothetical protein 0.0045 0.0143 0.0325
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0123
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.1445 1
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.002 0.001 0.0015
Trichomonas vaginalis inositol monophosphatase, putative 0.0191 0.0943 0.6368
Schistosoma mansoni loxhd1 0.0062 0.0237 0.0533
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0126 0.0282
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0048 0.0163 0.0371
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0009 0.0015
Plasmodium falciparum protein MAM3, putative 0.0048 0.0163 0.0395
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0012 0.0021
Onchocerca volvulus 0.029 0.1481 0.85
Echinococcus granulosus dna polymerase kappa 0.0019 0.0005 0.0005
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0167 0.0379
Schistosoma mansoni inositol monophosphatase 0.0191 0.0943 0.2144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0012 0.0021
Schistosoma mansoni ran 0.0022 0.0023 0.0046
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0068
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0005 0.0034
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0048 0.0163 0.0369
Chlamydia trachomatis SWIB complex protein 0.0021 0.0015 0.0326
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0185 0.0416
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative 0.002 0.001 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0056 0.0378
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0021 0.0015 0.0029
Echinococcus multilocularis SWI:SNF matrix associated 0.0021 0.0015 0.0027
Brugia malayi Glycosyl hydrolases family 31 protein 0.0077 0.0318 0.0728
Echinococcus multilocularis thioredoxin glutathione reductase 0.0139 0.066 0.1498
Brugia malayi RNA binding protein 0.0067 0.0263 0.0602
Schistosoma mansoni lipoxygenase 0.0239 0.1202 0.2733
Leishmania major CBS domain protein, conserved 0.0048 0.0163 0.0371
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0021
Echinococcus multilocularis dna polymerase eta 0.0019 0.0005 0.0005
Trypanosoma cruzi chloride channel protein, putative 0.0048 0.0163 0.0371
Schistosoma mansoni hypothetical protein 0.0823 0.4389 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.029 0.1481 0.3417
Treponema pallidum NADH oxidase 0.0048 0.0163 0.0849
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0012 0.0021
Echinococcus granulosus lysosomal alpha glucosidase 0.0345 0.1783 0.4058
Mycobacterium ulcerans beta-lactamase 0.029 0.1481 0.3414
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0764 0.4066 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0037 0.0078
Echinococcus multilocularis lipoxygenase domain containing protein 0.0062 0.0237 0.0533
Loa Loa (eye worm) doublecortin family protein 0.0062 0.0237 0.0541
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0029 0.0056 0.0378
Loa Loa (eye worm) IMP dehydrogenase 1 0.0812 0.4329 1
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0012 0.0014
Schistosoma mansoni zinc finger protein 0.0022 0.0022 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0033 0.0223
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0655 0.1503
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0021 0.0015 0.0027
Loa Loa (eye worm) thioredoxin reductase 0.0139 0.0657 0.1513
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0044 0.01
Brugia malayi jmjC domain containing protein 0.0191 0.094 0.2167
Schistosoma mansoni ran 0.0022 0.0023 0.0046
Trichomonas vaginalis alpha-glucosidase, putative 0.0029 0.0056 0.0378
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0048 0.0163 0.0393
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0223 0.051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0033 0.0223
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0299 0.0685
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0049 0.0331
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0012 0.0021
Onchocerca volvulus 0.0052 0.0185 0.1014
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0012 0.0021
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0077 0.0318 0.2173
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0171 0.0834 0.0829
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0012 0.0021
Trypanosoma cruzi myo-inositol-1 phosphatase, putative 0.002 0.001 0.0016
Brugia malayi ecdysteroid receptor 0.002 0.0012 0.0021
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0048 0.0163 0.0369
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0126 0.0674
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0012 0.0021
Echinococcus granulosus Polycystic kidney disease protein 0.0062 0.0237 0.0533
Echinococcus multilocularis zinc finger protein 0.0022 0.0022 0.0043
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0031 0.0064
Loa Loa (eye worm) hypothetical protein 0.0048 0.0163 0.0371
Loa Loa (eye worm) RNA binding protein 0.0067 0.0263 0.0602
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0036 0.0082
Loa Loa (eye worm) hypothetical protein 0.0052 0.0185 0.0422
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0033 0.0223
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0048 0.0163 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0033 0.0223
Brugia malayi PHD-finger family protein 0.0058 0.0218 0.0497
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.0318 0.0776
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0044 0.0094
Loa Loa (eye worm) hypothetical protein 0.0048 0.0163 0.0371
Mycobacterium tuberculosis Probable conserved lipoprotein 0.029 0.1481 0.1477
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0021 0.0015 0.0027
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0048 0.0163 0.0158
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0218 0.0529
Leishmania major chloride channel protein, putative 0.0048 0.0163 0.0371
Brugia malayi CLC chloride channel protein 0.0048 0.0163 0.0371
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0126 0.0853
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0005 0.0005
Onchocerca volvulus 0.0062 0.0237 0.1312
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0048 0.0163 0.0369

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 200 uM Inhibition of His-tagged-truncated human PDK1 preincubated with substrate biotinylated-AKT3 for 30 mins measured after 3 hrs by Scintillation proximity assay ChEMBL. 24900229

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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