TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 373.428 | Formula: C21H15N3O2S
H donors: 1 H acceptors: 3 LogP: 3.61 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cccc(c1)NC(=O)c1cc2c(s1)c1ccccc1n(c2=O)CC
InChi: 1S/C21H15N3O2S/c1-2-24-17-9-4-3-8-15(17)19-16(21(24)26)11-18(27-19)20(25)23-14-7-5-6-13(10-14)12-22/h3-11H,2H2,1H3,(H,23,25)
InChiKey: NFSFAGYKTWKMNU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0214	0.0715
Echinococcus granulosus	twitchin	0.0249	0.0414	0.0589
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0045	0.0043	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0426	0.1425
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0214	0.035	0.1171
Schistosoma mansoni	hypothetical protein	0.0023	0.0002	0.0001
Schistosoma mansoni	hypothetical protein	0.0023	0.0002	0.0001
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0026	0.0008	0.0027
Echinococcus granulosus	dnaJ subfamily B	0.0927	0.1648	0.2353
Trichomonas vaginalis	CAMK family protein kinase	0.1666	0.2993	1
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0049	0.005	0.0068
Trypanosoma cruzi	cytochrome P450, putative	0.0395	0.068	0.2202
Schistosoma mansoni	hypothetical protein	0.0023	0.0002	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0049	0.005	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0233	0.0385	0.1286
Schistosoma mansoni	hypothetical protein	0.0023	0.0002	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0244	0.0814
Echinococcus granulosus	neuropeptide receptor A26	0.0525	0.0916	0.1308
Schistosoma mansoni	protein kinase	0.0594	0.1041	0.104
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0025	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Echinococcus granulosus	titin	0.0023	0.0002	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0002	0.0008
Brugia malayi	Prion-like-	0.0045	0.0043	0.0145
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0049	0.005	0.0068
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.024	0.0398	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.024	0.0398	0.5
Schistosoma mansoni	cytochrome P450	0.024	0.0398	0.0396
Schistosoma mansoni	titin	0.0023	0.0002	0.0001
Loa Loa (eye worm)	TK/ROR protein kinase	0.0044	0.0041	0.0137
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0026	0.0009	0.0029
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0002	0.0008
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0049	0.005	0.0048
Echinococcus granulosus	leucine rich repeats and immunoglobulin	0.0023	0.0003	0.0001
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.024	0.0398	0.5
Brugia malayi	Cytochrome P450 family protein	0.0395	0.068	0.2273
Brugia malayi	Immunoglobulin domain containing protein	0.0022	0.0002	0.0006
Schistosoma mansoni	hypothetical protein	0.0023	0.0002	0.0001
Schistosoma mansoni	titin	0.0042	0.0037	0.0035
Brugia malayi	serine/threonine-protein kinase 6	0.0594	0.1041	0.3479
Echinococcus multilocularis	titin	0.0023	0.0002	0.0001
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0045	0.0043	0.0145
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0002	0.0008
Schistosoma mansoni	titin	0.0023	0.0002	0.0001
Schistosoma mansoni	cell adhesion molecule	0.0023	0.0002	0.0001
Brugia malayi	serine/threonine protein kinase 6	0.0594	0.1041	0.3479
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Schistosoma mansoni	myosin-binding protein-related	0.0026	0.0009	0.0007
Onchocerca volvulus		0.0023	0.0003	0.0009
Onchocerca volvulus		0.0042	0.0037	0.0123
Brugia malayi	Cytochrome P450 family protein	0.024	0.0398	0.1328
Trypanosoma cruzi	polo-like protein kinase, putative	0.1666	0.2993	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0002	0.0008
Echinococcus multilocularis	transfer RNA-Phe	0.0026	0.0009	0.001
Trichomonas vaginalis	CAMK family protein kinase	0.1666	0.2993	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.1666	0.2993	0.4277
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0594	0.1041	0.1486
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0021	0.02
Loa Loa (eye worm)	animal heme peroxidase	0.0023	0.0002	0.0008
Echinococcus granulosus	peroxidasin	0.0046	0.0044	0.006
Schistosoma mansoni	cpg binding protein	0.0069	0.0086	0.0084
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0038	0.003	0.0099
Loa Loa (eye worm)	jmjC domain-containing protein	0.0044	0.004	0.0134
Onchocerca volvulus	Peroxidasin homolog	0.0023	0.0003	0.0009
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.024	0.0398	0.1248
Loa Loa (eye worm)	TK protein kinase	0.0139	0.0214	0.0716
Loa Loa (eye worm)	CYP4Cod1	0.0395	0.068	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0306	0.0518	0.1732
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0045	0.0043	0.0145
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0042	0.0037	0.0123
Brugia malayi	Myb-like DNA-binding domain containing protein	0.0023	0.0002	0.0008
Echinococcus granulosus	tumor protein p63	0.0408	0.0704	0.1003
Brugia malayi	F/Y-rich N-terminus family protein	0.0032	0.0019	0.0063
Schistosoma mansoni	hypothetical protein	0.0026	0.0009	0.0007
Echinococcus multilocularis	hemicentin 1	0.0045	0.0043	0.0059
Onchocerca volvulus		0.0023	0.0002	0.0008
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.024	0.0398	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0594	0.1041	0.3479
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0594	0.1041	0.1486
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0045	0.0043	0.0042
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0049	0.005	0.0166
Echinococcus multilocularis	twitchin	0.0038	0.003	0.0041
Onchocerca volvulus		0.0026	0.0009	0.0029
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0026	0.0009	0.0029
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0045	0.0043	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Echinococcus multilocularis	neuropeptide s receptor	0.0525	0.0916	0.1308
Entamoeba histolytica	protein kinase, putative	0.0594	0.1041	0.3419
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0002	0.0008
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0045	0.0043	0.0059
Onchocerca volvulus	Netrin receptor homolog	0.0023	0.0002	0.0008
Onchocerca volvulus		0.0023	0.0002	0.0008
Echinococcus multilocularis	lachesin	0.0045	0.0043	0.0059
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0063	0.0212
Echinococcus multilocularis		0.0023	0.0002	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0002	0.0006
Echinococcus granulosus	down syndrome cell adhesion	0.0023	0.0002	0.0001
Schistosoma mansoni	titin	0.0026	0.0009	0.0007
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0594	0.1041	0.3419
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0025	0.0033
Schistosoma mansoni	neuroglian	0.0049	0.005	0.0048
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.1666	0.2993	1
Brugia malayi	Prion-like-	0.0023	0.0002	0.0008
Echinococcus multilocularis	titin	0.0042	0.0037	0.005
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.024	0.0398	0.5
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.024	0.0398	0.1248
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0026	0.0009	0.0029
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.024	0.0398	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0594	0.1041	0.104
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0026	0.0009	0.0029
Echinococcus multilocularis	hemicentin 1	0.0045	0.0043	0.0059
Schistosoma mansoni	cell adhesion molecule	0.0049	0.005	0.0048
Giardia lamblia	Aurora kinase	0.0594	0.1041	0.3434
Echinococcus multilocularis	Immunoglobulin	0.0211	0.0344	0.0489
Echinococcus granulosus	defective proboscis extension response	0.0211	0.0344	0.0489
Brugia malayi	serine/threonine kinase 12	0.0594	0.1041	0.3479
Echinococcus multilocularis	neuropeptide receptor A26	0.0525	0.0916	0.1308
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0023	0.0002	0.0008
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.024	0.0398	0.5
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0045	0.0043	0.0145
Loa Loa (eye worm)	AUR protein kinase	0.0594	0.1041	0.3479
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.024	0.0398	0.5
Onchocerca volvulus	Serine\/threonine kinase homolog	0.1666	0.2993	1
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0594	0.1041	1
Echinococcus granulosus	neuroglian	0.0233	0.0386	0.0549
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0049	0.005	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0043	0.0145
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0026	0.0009	0.0029
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.024	0.0398	0.5
Schistosoma mansoni	cell adhesion molecule	0.0049	0.005	0.0048
Brugia malayi	PHD-finger family protein	0.0033	0.0021	0.007
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0049	0.005	0.0068
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0026	0.0009	0.0029
Trypanosoma brucei	cytochrome P450, putative	0.0395	0.068	0.2202
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0037	0.0027	0.0037
Echinococcus multilocularis	Immunoglobulin	0.0211	0.0344	0.0489
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0042	0.0037	0.0123
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0049	0.005	0.0166
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0044	0.0041	0.0056
Schistosoma mansoni	titin	0.0023	0.0002	0.0001
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0044	0.004	0.0038
Brugia malayi	Cytochrome P450 family protein	0.0917	0.1629	0.5443
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0021	0.02
Brugia malayi	cytochrome P450	0.024	0.0398	0.1328
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0211	0.0344	0.0342
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0033	0.0021	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0344	0.1149
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0344	0.1149
Brugia malayi	Bromodomain containing protein	0.0033	0.0021	0.007
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Onchocerca volvulus		0.0023	0.0002	0.0008
Schistosoma mansoni	slit	0.0023	0.0003	0.0001
Onchocerca volvulus		0.0026	0.0009	0.0029
Trichomonas vaginalis	CAMK family protein kinase	0.1666	0.2993	1
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.024	0.0398	0.1248
Brugia malayi	Pre-SET motif family protein	0.0237	0.0392	0.1309
Plasmodium falciparum	protein kinase, putative	0.0037	0.0027	0.0263
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0025	0.0239
Echinococcus granulosus	nephrin	0.0026	0.0009	0.001
Entamoeba histolytica	protein kinase, putative	0.0594	0.1041	0.3419
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0009	0.0029
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0023	0.0002	0.0001
Echinococcus granulosus	roundabout 2	0.0259	0.0433	0.0616
Onchocerca volvulus	Alhambra homolog	0.0033	0.0021	0.007
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0026	0.0009	0.0029
Brugia malayi	hypothetical protein	0.0306	0.0518	0.1732
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0043	0.0145
Brugia malayi	Immunoglobulin domain containing protein	0.0022	0.0002	0.0006
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0026	0.0009	0.0029
Onchocerca volvulus	Peroxidasin homolog	0.0023	0.0002	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Trypanosoma cruzi	cytochrome P450, putative	0.0395	0.068	0.2202
Echinococcus granulosus	cytochrome P450 2K1	0.024	0.0398	0.0566
Trichomonas vaginalis	CAMK family protein kinase	0.1666	0.2993	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0023	0.0002	0.0008
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0045	0.0043	0.0145
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0023	0.0002	0.0008
Brugia malayi	hypothetical protein	0.0139	0.0214	0.0715
Brugia malayi	Immunoglobulin I-set domain containing protein	0.1278	0.2287	0.764
Brugia malayi	Prion-like-	0.0023	0.0002	0.0008
Echinococcus granulosus	neuroglian	0.0049	0.005	0.0068
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.1666	0.2993	1
Brugia malayi	basement membrane proteoglycan precursor	0.0022	0.0002	0.0006
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0037	0.0027	0.0037
Trichomonas vaginalis	CAMK family protein kinase	0.1666	0.2993	1
Brugia malayi	Peroxidasin	0.0046	0.0044	0.0146
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0117	0.0173	0.0245
Schistosoma mansoni	cell adhesion molecule	0.0045	0.0043	0.0042
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0023	0.0002	0.0001
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0026	0.0008	0.0009
Schistosoma mansoni	jumonji domain containing protein	0.0086	0.0117	0.0115
Entamoeba histolytica	serine/threonine protein kinase, putative	0.1666	0.2993	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Echinococcus multilocularis	cpg binding protein	0.0069	0.0086	0.012
Schistosoma mansoni	hypothetical protein	0.0039	0.0031	0.0029
Onchocerca volvulus	Huntingtin homolog	0.0139	0.0214	0.0715
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0025	0.0083
Brugia malayi	Prion-like-	0.0023	0.0002	0.0008
Echinococcus granulosus	contactin	0.0049	0.005	0.0068
Brugia malayi	hypothetical protein	0.0214	0.035	0.1171
Mycobacterium leprae	Conserved hypothetical protein	0.024	0.0398	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Echinococcus multilocularis	tumor protein p63	0.0408	0.0704	0.1003
Brugia malayi	Leucine Rich Repeat family protein	0.0023	0.0003	0.0009
Echinococcus granulosus	titin	0.0023	0.0002	0.0001
Schistosoma mansoni	titin	0.0023	0.0002	0.0001
Loa Loa (eye worm)	cytochrome P450 family protein	0.0917	0.1629	0.5443
Echinococcus granulosus	lachesin	0.0045	0.0043	0.0059
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0108	0.0157	0.0222
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.024	0.0398	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0037	0.0027	0.0263
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0002	0.0006
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0025	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0426	0.1425
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0025	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Entamoeba histolytica	protein kinase , putative	0.0594	0.1041	0.3419
Loa Loa (eye worm)	hypothetical protein	0.0139	0.0214	0.0715
Onchocerca volvulus		0.0269	0.0451	0.1506
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0125	0.0187	0.18
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0044	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0009	0.0029
Schistosoma mansoni	ephrin receptor	0.0025	0.0006	0.0004
Schistosoma mansoni	cell adhesion molecule	0.0026	0.0009	0.0007
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.024	0.0398	0.5
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0026	0.0009	0.0029
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0045	0.0043	0.0145
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0049	0.005	0.0166
Brugia malayi	jmjC domain containing protein	0.0108	0.0157	0.0526
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0044	0.004	0.0038
Echinococcus granulosus	hemicentin 1	0.0045	0.0043	0.0059
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0002	0.0008
Schistosoma mansoni	hemicentin	0.0026	0.0009	0.0007
Echinococcus multilocularis	roundabout 2	0.0049	0.005	0.0068
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0139	0.0214	0.0716
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.1666	0.2993	0.4277
Trichomonas vaginalis	AGC family protein kinase	0.0594	0.1041	0.3479
Onchocerca volvulus		0.0023	0.0002	0.0008
Brugia malayi	Pre-SET motif family protein	0.0035	0.0025	0.0083
Schistosoma mansoni	hypothetical protein	0.0023	0.0002	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0214	0.035	0.1171
Echinococcus granulosus	aurora kinase A	0.0594	0.1041	0.1486
Echinococcus granulosus	peregrin	0.0033	0.0021	0.0027
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0023	0.0002	0.0008
Brugia malayi	basement membrane proteoglycan	0.0022	0.0002	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0002	0.0006
Echinococcus granulosus	titin	0.0023	0.0002	0.0001
Loa Loa (eye worm)	transcription factor SMAD2	0.0136	0.0208	0.0693
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0028	0.0012	0.001
Echinococcus granulosus	roundabout 2	0.0049	0.005	0.0068
Onchocerca volvulus		0.0023	0.0002	0.0008
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.024	0.0398	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.024	0.0398	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.1666	0.2993	0.2992
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0002	0.0008
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0021	0.02
Echinococcus multilocularis	activin receptor type	0.0037	0.0027	0.0037
Schistosoma mansoni	protein kinase	0.0037	0.0027	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0064	0.0213
Trichomonas vaginalis	set domain proteins, putative	0.0269	0.0451	0.1506
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0117	0.0173	0.0245
Echinococcus multilocularis	titin	0.0023	0.0002	0.0001
Echinococcus multilocularis	Serine:threonine protein kinase PLK4	0.3865	0.6996	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.007	0.0068
Echinococcus multilocularis	titin	0.0023	0.0002	0.0001
Schistosoma mansoni	nephrin	0.0049	0.005	0.0048
Brugia malayi	serine/threonine-protein kinase plk-2	0.1666	0.2993	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0025	0.0006	0.0006
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0045	0.0043	0.0145
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0037	0.0027	0.0037
Trichomonas vaginalis	CAMK family protein kinase	0.1666	0.2993	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0002	0.0006
Onchocerca volvulus		0.0023	0.0002	0.0008
Brugia malayi	Disorganized muscle protein 1	0.0023	0.0002	0.0008
Echinococcus multilocularis	leucine rich repeats and immunoglobulin	0.0023	0.0003	0.0001
Trypanosoma brucei	aurora B kinase	0.0594	0.1041	0.3419
Loa Loa (eye worm)	disorganized muscle protein 1	0.0023	0.0002	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0002	0.0006
Loa Loa (eye worm)	PHD-finger family protein	0.0033	0.0021	0.007
Loa Loa (eye worm)	cytochrome P450 family protein	0.0395	0.068	0.2273
Schistosoma mansoni	septate junction protein	0.0045	0.0043	0.0042
Schistosoma mansoni	nephrin related	0.0023	0.0002	0.0001
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0395	0.068	1
Schistosoma mansoni	tyrosine kinase	0.0117	0.0173	0.0171
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0025	0.0023
Echinococcus multilocularis		0.024	0.0398	0.0566
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0002	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0063	0.0212
Schistosoma mansoni	hypothetical protein	0.0927	0.1648	0.1646
Loa Loa (eye worm)	AUR protein kinase	0.0594	0.1041	0.3479
Schistosoma mansoni	protein kinase	0.0037	0.0027	0.0026
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0002	0.0007
Brugia malayi	Heparan sulfate	0.0022	0.0002	0.0006
Giardia lamblia	Kinase, PLK	0.1666	0.2993	1
Echinococcus granulosus	cpg binding protein	0.0069	0.0086	0.012
Leishmania major	cytochrome p450-like protein	0.024	0.0398	0.1248
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0002	0.0006
Echinococcus granulosus	activin receptor type	0.0037	0.0027	0.0037
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0037	0.0035
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.024	0.0398	0.1248
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.1278	0.2287	0.764
Loa Loa (eye worm)	cytochrome P450	0.024	0.0398	0.1328
Echinococcus granulosus	Opioid binding protein:cell adhesion molecule	0.0023	0.0002	0.0001
Echinococcus multilocularis	jumonji domain containing protein	0.0046	0.0044	0.0061
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0025	0.0023
Schistosoma mansoni	cell adhesion molecule	0.0026	0.0009	0.0007
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.024	0.0398	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0002	0.0008
Trypanosoma brucei	polo-like protein kinase	0.1666	0.2993	1
Onchocerca volvulus	Putative titin	0.0023	0.0002	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Trichomonas vaginalis	AGC family protein kinase	0.0594	0.1041	0.3479
Schistosoma mansoni	tyrosine kinase	0.0066	0.0082	0.008
Plasmodium falciparum	phd finger protein, putative	0.0033	0.0021	0.02
Loa Loa (eye worm)	cytochrome P450 family protein	0.0395	0.068	0.2273
Echinococcus multilocularis	tyrosine protein kinase otk	0.0045	0.0043	0.0059
Echinococcus granulosus	tyrosine protein kinase otk	0.0045	0.0043	0.0059
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0594	0.1041	1
Echinococcus multilocularis	Opioid binding protein:cell adhesion molecule	0.0023	0.0002	0.0001
Schistosoma mansoni	cell adhesion molecule	0.0237	0.0391	0.039
Brugia malayi	Immunoglobulin domain containing protein	0.0022	0.0002	0.0006
Loa Loa (eye worm)	projectin	0.0026	0.0009	0.0029
Loa Loa (eye worm)	AUR protein kinase	0.0594	0.1041	0.3479
Echinococcus multilocularis	neuroglian	0.0049	0.005	0.0068
Onchocerca volvulus		0.0065	0.0079	0.0265
Echinococcus multilocularis	peroxidasin	0.0046	0.0044	0.006
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0233	0.0385	0.0548
Loa Loa (eye worm)	hypothetical protein	0.0211	0.0344	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0214	0.035	0.1171
Onchocerca volvulus		0.1024	0.1824	0.6095
Loa Loa (eye worm)	hypothetical protein	0.0214	0.035	0.1171
Mycobacterium leprae	putative cytochrome p450	0.024	0.0398	0.5
Echinococcus multilocularis	insulin growth factor binding	0.0023	0.0002	0.0001
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0002	0.0008
Echinococcus granulosus	insulin growth factor binding	0.0023	0.0002	0.0001
Toxoplasma gondii	cytochrome p450 superfamily protein	0.024	0.0398	0.3818
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0117	0.0173	0.0245
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0033	0.0021	0.0019
Brugia malayi	Animal haem peroxidase family protein	0.0023	0.0002	0.0008
Loa Loa (eye worm)	one IG domain family member	0.0023	0.0002	0.0008
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0108	0.0157	0.0222
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0002	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0043	0.0145
Echinococcus multilocularis	down syndrome cell adhesion	0.0023	0.0002	0.0001
Loa Loa (eye worm)	hypothetical protein	0.006	0.007	0.0232
Schistosoma mansoni	septate junction protein	0.0045	0.0043	0.0042
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0594	0.1041	0.3419
Schistosoma mansoni	vesicular amine transporter	0.0211	0.0344	0.0342
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0026	0.0008	0.0027
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.024	0.0398	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0044	0.0041	0.0056
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0038	0.003	0.0099
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0117	0.0173	0.0245
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0045	0.0043	0.0145
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.024	0.0398	0.1248
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0025	0.0023
Brugia malayi	kettin	0.0023	0.0002	0.0008
Trypanosoma cruzi	aurora B kinase, putative	0.0594	0.1041	0.3419
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0065	0.0079	0.0265
Onchocerca volvulus		0.006	0.007	0.0232
Echinococcus multilocularis	roundabout 2	0.0259	0.0433	0.0616
Echinococcus granulosus	jumonji domain containing protein	0.0046	0.0044	0.0061
Brugia malayi	jmjC domain containing protein	0.0044	0.004	0.0134
Plasmodium vivax	SET domain protein, putative	0.0035	0.0025	0.0239
Brugia malayi	protein unc-22	0.0042	0.0037	0.0123
Schistosoma mansoni	titin	0.0023	0.0002	0.0001
Echinococcus granulosus	neuropeptide s receptor	0.0525	0.0916	0.1308
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Brugia malayi	MH2 domain containing protein	0.0136	0.0208	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Echinococcus granulosus	PHD finger protein rhinoceros	0.0033	0.0021	0.0027
Schistosoma mansoni	titin	0.0045	0.0043	0.0042
Echinococcus multilocularis	dnaJ subfamily B	0.0927	0.1648	0.2353
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.024	0.0398	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0594	0.1041	0.3419
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0063	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0002	0.0006
Echinococcus multilocularis	peregrin	0.0033	0.0021	0.0027
Leishmania major	cytochrome p450-like protein	0.0395	0.068	0.2202
Echinococcus multilocularis	roundabout 2	0.0049	0.005	0.0068
Brugia malayi	Fibronectin type III domain containing protein	0.0214	0.035	0.1171
Schistosoma mansoni	protein kinase	0.0037	0.0027	0.0026
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0023	0.0002	0.0008
Toxoplasma gondii	aurora kinase	0.0594	0.1041	1
Brugia malayi	Cytochrome P450 family protein	0.0395	0.068	0.2273
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0031	0.0103
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.024	0.0398	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.024	0.0398	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0025	0.0006	0.0006
Loa Loa (eye worm)	jmjC domain-containing protein	0.0068	0.0085	0.0283
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0211	0.0344	0.0342
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0237	0.0392	0.1309
Echinococcus multilocularis	aurora kinase A	0.0594	0.1041	0.1486
Onchocerca volvulus	Tyrosine kinase homolog	0.1068	0.1904	0.6362
Brugia malayi	hypothetical protein	0.0022	0.0002	0.0006
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0594	0.1041	0.3419
Leishmania major	cytochrome p450-like protein	0.024	0.0398	0.1248
Schistosoma mansoni	roundabout	0.0045	0.0043	0.0042
Onchocerca volvulus		0.0035	0.0025	0.0083
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.024	0.0398	0.5
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0043	0.0145
Echinococcus granulosus	lysine specific demethylase 5A	0.0044	0.004	0.0055
Echinococcus granulosus	titin	0.0042	0.0037	0.005
Echinococcus multilocularis	neuroglian	0.0233	0.0386	0.0549
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0021	0.007
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0049	0.005	0.0068
Echinococcus granulosus	Serine:threonine protein kinase PLK4	0.3865	0.6996	1
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0211	0.0344	0.0489
Schistosoma mansoni	cpg binding protein	0.0069	0.0086	0.0084
Loa Loa (eye worm)	LAD-2 short isoform	0.0022	0.0002	0.0006
Brugia malayi	Wrapper/rega-1/klingon homolog protein 1	0.0023	0.0002	0.0008
Leishmania major	protein kinase, putative	0.0594	0.1041	0.3419
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0063	0.0212
Loa Loa (eye worm)	immunoglobulin domain-containing protein	0.0022	0.0002	0.0006
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0139	0.0214	0.0213
Loa Loa (eye worm)	MH2 domain-containing protein	0.0136	0.0208	0.0693
Schistosoma mansoni	hypothetical protein	0.024	0.0398	0.0396
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0031	0.0103
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.024	0.0398	0.5
Echinococcus granulosus	Immunoglobulin	0.0211	0.0344	0.0489
Echinococcus granulosus	titin	0.0042	0.0037	0.005
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0026	0.0008	0.0009
Trypanosoma cruzi	polo-like protein kinase, putative	0.1666	0.2993	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0043	0.0145
Echinococcus granulosus	leucine rich repeat containing protein 4	0.0023	0.0002	0.0001
Onchocerca volvulus	Huntingtin homolog	0.0139	0.0214	0.0715
Schistosoma mansoni	hypothetical protein	0.0033	0.0021	0.0019
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.002	0.0026
Schistosoma mansoni	nephrin	0.0237	0.0392	0.039
Onchocerca volvulus		0.0023	0.0002	0.0008
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0026	0.0009	0.001
Trichomonas vaginalis	AGC family protein kinase	0.0594	0.1041	0.3479
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.003	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0043	0.0145
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0064	0.0078	0.0259
Trichomonas vaginalis	CAMK family protein kinase	0.1666	0.2993	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0002	0.0008
Brugia malayi	CXXC zinc finger family protein	0.0065	0.0079	0.0265
Echinococcus granulosus	roundabout 2	0.0049	0.005	0.0068
Echinococcus multilocularis	lysine specific demethylase 5A	0.004	0.0033	0.0045
Schistosoma mansoni	cpg binding protein	0.0065	0.0079	0.0077
Loa Loa (eye worm)	CAMK protein kinase	0.0042	0.0037	0.0123
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0049	0.005	0.0068
Schistosoma mansoni	subfamily M23B non-peptidase homologue (M23 family)	0.0023	0.0002	0.0001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 827661