Detailed information for compound 933242

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 461.506 | Formula: C27H27NO6
  • H donors: 3 H acceptors: 3 LogP: 3.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@]1(O[C@@H]2N3[C@H]1O[C@@]([C@@H]3O[C@]2(C)c1ccc(cc1)O)(C)c1ccc(cc1)O)c1ccc(cc1)O
  • InChi: 1S/C27H27NO6/c1-25(16-4-10-19(29)11-5-16)22-28-23(32-25)26(2,17-6-12-20(30)13-7-17)34-24(28)27(3,33-22)18-8-14-21(31)15-9-18/h4-15,22-24,29-31H,1-3H3/t22-,23-,24-,25-,26-,27+/m0/s1
  • InChiKey: HATGEKWRCZEUHZ-DXSZVSTRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus opioid receptor, delta 1 Starlite/ChEMBL References
Mus musculus opioid receptor, mu 1 Starlite/ChEMBL References
Cavia porcellus Kappa opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Mitochondrial inner membrane protein homolog Kappa opioid receptor   380 aa 334 aa 25.4 %
Schistosoma japonicum Rhodopsin, putative Kappa opioid receptor   380 aa 329 aa 23.1 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 320 aa 20.6 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Kappa opioid receptor   380 aa 389 aa 25.7 %
Echinococcus granulosus somatostatin receptor Kappa opioid receptor   380 aa 342 aa 19.6 %
Onchocerca volvulus Kappa opioid receptor   380 aa 374 aa 27.5 %
Brugia malayi hypothetical protein Kappa opioid receptor   380 aa 319 aa 21.6 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Kappa opioid receptor   380 aa 326 aa 25.2 %
Onchocerca volvulus Phospholipase d-related homolog Kappa opioid receptor   380 aa 326 aa 20.9 %
Onchocerca volvulus Kappa opioid receptor   380 aa 310 aa 25.8 %
Onchocerca volvulus Mitogen-activated protein kinase kinase kinase 8 homolog Kappa opioid receptor   380 aa 395 aa 20.3 %
Echinococcus multilocularis allatostatin A receptor Kappa opioid receptor   380 aa 313 aa 27.2 %
Onchocerca volvulus Kappa opioid receptor   380 aa 310 aa 27.4 %
Schistosoma mansoni rhodopsin-like orphan GPCR Kappa opioid receptor   380 aa 379 aa 22.4 %
Brugia malayi GnHR receptor homolog Kappa opioid receptor   380 aa 341 aa 20.2 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Kappa opioid receptor   380 aa 313 aa 26.2 %
Echinococcus granulosus thyrotropin releasing hormone receptor Kappa opioid receptor   380 aa 392 aa 25.8 %
Onchocerca volvulus Programmed cell death protein 5 homolog Kappa opioid receptor   380 aa 316 aa 22.2 %
Echinococcus granulosus allatostatin A receptor Kappa opioid receptor   380 aa 317 aa 28.4 %
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Kappa opioid receptor   380 aa 306 aa 21.2 %
Brugia malayi ORL1-like opioid receptor Kappa opioid receptor   380 aa 312 aa 25.3 %
Schistosoma japonicum ko:K04255 opsin 4 (melanopsin), putative Kappa opioid receptor   380 aa 352 aa 20.2 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Kappa opioid receptor   380 aa 403 aa 23.3 %
Onchocerca volvulus Kappa opioid receptor   380 aa 310 aa 24.2 %
Onchocerca volvulus Phosphoinositide 3-kinase adapter subunit homolog Kappa opioid receptor   380 aa 323 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0198 0.0992 1
Entamoeba histolytica protein kinase 2, putative 0.0017 0.0024 0.0207
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0047 0.0155
Echinococcus granulosus family S9 non peptidase ue S09 family 0.005 0.0198 0.0195
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0024 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.0668 0.0665
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0031 0.0031
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0017 0.0024 0.002
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Brugia malayi hypothetical protein 0.0112 0.0531 0.0531
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0133 0.0133
Loa Loa (eye worm) melatonin receptor type 1A 0.0112 0.0531 0.0528
Entamoeba histolytica cell division protein kinase 2, putative 0.004 0.0144 0.1423
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Leishmania major glycosyl hydrolase-like protein 0.0074 0.0327 0.0303
Brugia malayi ORL1-like opioid receptor 0.0112 0.0531 0.0531
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1123 0.5935 0.5933
Trichomonas vaginalis alpha-glucosidase, putative 0.0198 0.0992 0.6693
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0031 0.0028
Brugia malayi Glutamate receptor 1 precursor 0.0024 0.0059 0.0059
Echinococcus granulosus allatostatin A receptor 0.0112 0.0531 0.0528
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0667 0.35 1
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0038 0.0135 0.0132
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0107 0.0104
Mycobacterium tuberculosis Probable lipase LipD 0.0104 0.0491 0.1342
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.023 0.0227
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1123 0.5935 0.5935
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0017 0.0024 0.002
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0141 0.0138
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0141 0.0138
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0021 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0104 0.0491 0.3226
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0075 0.0348
Brugia malayi Protein kinase domain containing protein 0.0013 0.0003 0.0003
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0062 0.0038
Echinococcus granulosus biogenic amine 5HT receptor 0.0112 0.0531 0.0528
Schistosoma mansoni microtubule-associated protein tau 0.1611 0.8549 0.8549
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.0531 0.0528
Schistosoma mansoni growth hormone secretagogue receptor 0.0112 0.0531 0.0528
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.0531 0.0528
Schistosoma mansoni tar DNA-binding protein 0.0039 0.0143 0.014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0104 0.0491 0.0488
Brugia malayi nuclear receptor NHR-88 0.0018 0.0031 0.0031
Brugia malayi hypothetical protein 0.0112 0.0531 0.0531
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Echinococcus granulosus carbonic anhydrase II 0.1883 1 1
Brugia malayi fructose-1,6-bisphosphatase 0.0666 0.3494 0.3494
Brugia malayi Dopamine receptor protein 2 0.0112 0.0531 0.0531
Loa Loa (eye worm) RNA binding protein 0.0039 0.0143 0.014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0282 0.0278
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0104 0.0489 0.0486
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0141 0.0138
Loa Loa (eye worm) hypothetical protein 0.0294 0.1504 0.1501
Echinococcus multilocularis sex peptide receptor 0.0112 0.0531 0.0528
Brugia malayi RNA recognition motif domain containing protein 0.0039 0.0143 0.0143
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0039 0.0143 0.014
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0036
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0024 0.0001
Brugia malayi RE15519p 0.0112 0.0531 0.0531
Brugia malayi neuropeptide F receptor 0.0112 0.0531 0.0531
Schistosoma mansoni hypothetical protein 0.043 0.2232 0.223
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0031 0.0028
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0062 0.0062
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0055 0.0224 0.0221
Brugia malayi cell division control protein 2 homolog 0.004 0.0144 0.0144
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0069 0.0305
Echinococcus granulosus cyclin dependent kinase 1 0.004 0.0144 0.0141
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0031 0.0103
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.0607 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0198 0.0992 0.6693
Onchocerca volvulus 0.027 0.1378 0.5112
Trichomonas vaginalis glutaminase, putative 0.0287 0.147 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.0067
Brugia malayi hypothetical protein 0.0018 0.0031 0.0031
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0737 0.3873 0.3871
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0198 0.05
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Trichomonas vaginalis D-aminoacylase, putative 0.0104 0.0491 0.3226
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1123 0.5935 0.5935
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0244 0.1517
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0244 0.0241
Brugia malayi RNA binding protein 0.0039 0.0143 0.0143
Schistosoma mansoni biogenic amine (5HT) receptor 0.0112 0.0531 0.0528
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0062 0.0058
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0031 0.0028
Onchocerca volvulus 0.005 0.0198 0.0724
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Onchocerca volvulus 0.0018 0.0031 0.0103
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0133 0.013
Brugia malayi G protein-coupled receptor F59B2.13 0.0112 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Brugia malayi AKH receptor 0.0112 0.0531 0.0531
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0141 0.0138
Brugia malayi CXXC zinc finger family protein 0.003 0.0094 0.0094
Brugia malayi Tachykinin-like peptides receptor 99D 0.0112 0.0531 0.0531
Loa Loa (eye worm) carboxylesterase 0.005 0.0198 0.0195
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0195
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0141 0.0138
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.005 0.0198 0.12
Brugia malayi hypothetical protein 0.005 0.0198 0.0198
Echinococcus granulosus lamin 0.0056 0.023 0.0227
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0118 0.0115
Loa Loa (eye worm) hypothetical protein 0.0036 0.0124 0.0121
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0047 0.0155
Schistosoma mansoni hypothetical protein 0.0017 0.0021 0.0018
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0062 0.0058
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0223 0.022
Trypanosoma brucei trypanothione reductase 0.005 0.0198 0.0174
Schistosoma mansoni biogenic amine receptor 0.0112 0.0531 0.0528
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.005 0.0198 0.0195
Echinococcus granulosus orexin receptor type 2 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0028
Brugia malayi hypothetical protein 0.0021 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0017 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0076 0.0073
Brugia malayi Glutamate receptor 2 precursor 0.0024 0.0059 0.0059
Echinococcus multilocularis neuropeptide receptor 0.0112 0.0531 0.0528
Echinococcus granulosus tyrosine protein kinase shark 0.0013 0.0003 0.0000000076168
Echinococcus multilocularis carbonic anhydrase II 0.1883 1 1
Mycobacterium ulcerans carboxylesterase, LipT 0.005 0.0198 0.12
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.013
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Trypanosoma brucei rac serine-threonine kinase, putative 0.0025 0.0069 0.0044
Onchocerca volvulus 0.0112 0.0531 0.1962
Echinococcus granulosus carbonic anhydrase 0.1123 0.5935 0.5933
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0141 0.0141
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0141 0.0513
Echinococcus multilocularis lamin dm0 0.0056 0.023 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0141 0.0141
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0118 0.0565 0.0562
Brugia malayi Protein kinase domain containing protein 0.0013 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.0489 0.0486
Schistosoma mansoni ATP-binding cassette transporter 0.0024 0.0059 0.0056
Schistosoma mansoni rab6-interacting 0.002 0.0039 0.0036
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0112 0.0531 0.0528
Onchocerca volvulus 0.005 0.0198 0.0724
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0028
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.0531 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0133 0.0752
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Echinococcus multilocularis neuropeptides capa receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) DR-78 0.0018 0.0031 0.0028
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0057 0.0239 0.0236
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Onchocerca volvulus 0.0112 0.0531 0.1962
Entamoeba histolytica protein kinase, putative 0.0025 0.0069 0.0661
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0039 0.0036
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0198 0.0992 0.6693
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0024 0.0021
Schistosoma mansoni carbonic anhydrase-related 0.1123 0.5935 0.5933
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0244 0.0244
Echinococcus granulosus cyclin dependent kinase 0.004 0.0144 0.0141
Loa Loa (eye worm) hypothetical protein 0.0035 0.0118 0.0115
Echinococcus multilocularis dro:myosuppressin receptor 0.0112 0.0531 0.0528
Brugia malayi hypothetical protein 0.0112 0.0531 0.0531
Echinococcus granulosus serine threonine protein kinase nrc 0.0017 0.0024 0.002
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0016 0.002 0.0017
Echinococcus granulosus neuropeptide receptor A26 0.0112 0.0531 0.0528
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Brugia malayi Protein kinase domain containing protein 0.0025 0.0069 0.0069
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0031 0.0028
Leishmania major carbonic anhydrase-like protein 0.1883 1 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.005 0.0198 0.0499
Echinococcus multilocularis neuropeptide receptor 0.0112 0.0531 0.0528
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0016 0.002 0.0017
Plasmodium falciparum importin beta, putative 0.0033 0.0108 0.0143
Mycobacterium ulcerans esterase/lipase LipP 0.0104 0.0491 0.3226
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0141 0.0138
Echinococcus granulosus 7tm_1 domain containing protein 0.0112 0.0531 0.0528
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0327 0.2093
Loa Loa (eye worm) carboxylesterase 0.0294 0.1504 0.1501
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0076 0.0073
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0047 0.0022
Brugia malayi conserved hypotetical protein 0.0018 0.0031 0.0031
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0666 0.3494 0.3492
Echinococcus granulosus G protein coupled receptor 139 0.0112 0.0531 0.0528
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.004 0.0144 0.012
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0141 0.0141
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0198 0.0175
Echinococcus multilocularis tyrosine protein kinase shark 0.0013 0.0003 0.0000000076168
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.0668 0.0665
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0069 0.0305
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0057 0.0239 0.0236
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Schistosoma mansoni amine GPCR 0.0112 0.0531 0.0528
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0112 0.0531 0.0528
Echinococcus granulosus neuropeptide FF receptor 2 0.0112 0.0531 0.0528
Echinococcus multilocularis lysosomal alpha glucosidase 0.0893 0.4706 0.4705
Onchocerca volvulus 0.0112 0.0531 0.1962
Brugia malayi sulfakinin receptor protein 0.0112 0.0531 0.0531
Schistosoma mansoni hypothetical protein 0.0118 0.0565 0.0562
Echinococcus multilocularis lysosomal alpha glucosidase 0.0893 0.4706 0.4705
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0198 0.0992 0.1636
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Brugia malayi hypothetical protein 0.0013 0.0003 0.0003
Schistosoma mansoni lipoxygenase 0.002 0.0039 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.0489 0.0486
Brugia malayi glutaminase DH11.1 0.0287 0.147 0.147
Echinococcus multilocularis carbonic anhydrase 0.1123 0.5935 0.5933
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1883 1 1
Schistosoma mansoni ap endonuclease 0.0021 0.0047 0.0044
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0141 0.0138
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0248 0.1257 0.1235
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.0001
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.005 0.0198 0.0195
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0047 1
Echinococcus multilocularis carboxylesterase 5A 0.0294 0.1504 0.1501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0531 0.0528
Echinococcus granulosus lysosomal alpha glucosidase 0.0893 0.4706 0.4705
Echinococcus granulosus acetylcholinesterase 0.0294 0.1504 0.1501
Echinococcus multilocularis glutamate receptor 2 0.0024 0.0059 0.0056
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0112 0.0531 0.0528
Onchocerca volvulus 0.0112 0.0531 0.1962
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0531 0.0528
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0141 0.0141
Echinococcus granulosus g protein coupled receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0026 0.007 0.0067
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0024 0.0018
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0076 0.0073
Echinococcus granulosus dnaJ subfamily B 0.043 0.2232 0.223
Echinococcus granulosus neuropeptide receptor 0.0112 0.0531 0.0528
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0039 0.0337
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0112 0.0531 0.0528
Schistosoma mansoni hypothetical protein 0.0083 0.0377 0.0374
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0531 0.0528
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0213 0.0213
Leishmania major alpha glucosidase II subunit, putative 0.0198 0.0992 0.097
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0133 0.013
Brugia malayi Importin beta-1 subunit 0.0033 0.0108 0.0108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0141 0.0141
Schistosoma mansoni serine/threonine-protein kinase 0.0017 0.0024 0.002
Schistosoma mansoni thyroid hormone receptor 0.0122 0.0586 0.0583
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0025 0.0069 0.0065
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0141 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0198 0.0992 0.097
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Echinococcus granulosus nervana 2 0.0016 0.002 0.0017
Loa Loa (eye worm) glutathione reductase 0.005 0.0198 0.0195
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0141 0.0513
Brugia malayi hypothetical protein 0.0112 0.0531 0.0531
Schistosoma mansoni alpha glucosidase 0.0198 0.0992 0.0989
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.004 0.0144 0.0141
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0133 0.0752
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0108 0.0084
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.0531 0.0528
Echinococcus granulosus acetylcholinesterase 0.0294 0.1504 0.1501
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0028
Echinococcus multilocularis somatostatin receptor 0.0112 0.0531 0.0528
Echinococcus granulosus Glutaredoxin protein 5 0.0016 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Schistosoma mansoni hypothetical protein 0.0112 0.0531 0.0528
Echinococcus multilocularis BC026374 protein (S09 family) 0.005 0.0198 0.0195
Onchocerca volvulus 0.0035 0.0118 0.0425
Schistosoma mansoni neuropeptide receptor 0.0112 0.0531 0.0528
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0138
Echinococcus granulosus 7TM GPCR rhodopsin 0.0112 0.0531 0.0528
Echinococcus granulosus somatostatin receptor 0.0112 0.0531 0.0528
Brugia malayi Tyrosine-protein kinase abl-1 0.0013 0.0003 0.0003
Echinococcus multilocularis Glutaredoxin protein 5 0.0016 0.002 0.0017
Onchocerca volvulus 0.0112 0.0531 0.1962
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0531 0.0528
Echinococcus multilocularis fmrfamide receptor 0.0112 0.0531 0.0528
Brugia malayi MH2 domain containing protein 0.0138 0.0668 0.0668
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0118 0.0115
Schistosoma mansoni alpha-glucosidase 0.0768 0.4042 0.404
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0294 0.1504 0.1501
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0118 0.0158
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0112 0.0531 0.0528
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0104 0.0491 0.0488
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) glutaminase 2 0.0287 0.147 0.1467
Echinococcus granulosus tar DNA binding protein 0.0039 0.0143 0.014
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Echinococcus multilocularis G protein coupled receptor 139 0.0112 0.0531 0.0528
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0075 0.0348
Echinococcus granulosus neutral alpha glucosidase AB 0.0198 0.0992 0.0989
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0031 0.0028
Leishmania major importin beta-1 subunit, putative 0.0027 0.0075 0.005
Echinococcus multilocularis acetylcholinesterase 0.0294 0.1504 0.1501
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.004
Brugia malayi GnHR receptor homolog 0.0112 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0112 0.0531 0.0528
Echinococcus multilocularis microtubule associated protein 2 0.1611 0.8549 0.8549
Schistosoma mansoni hypothetical protein 0.1123 0.5935 0.5933
Echinococcus multilocularis acetylcholinesterase 0.0294 0.1504 0.1501
Toxoplasma gondii exonuclease III APE 0.0021 0.0047 0.0038
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Brugia malayi Carboxylesterase family protein 0.0294 0.1504 0.1504
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0039 0.0027
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0232 0.0229
Onchocerca volvulus 0.0112 0.0531 0.1962
Echinococcus granulosus g protein coupled receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.004
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0024 0.0021
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.0531 0.0528
Onchocerca volvulus 0.0056 0.023 0.0843
Brugia malayi follicle stimulating hormone receptor 0.0112 0.0531 0.0531
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0031 0.0028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0213 0.021
Schistosoma mansoni tar DNA-binding protein 0.0039 0.0143 0.014
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0104 0.0491 0.3226
Entamoeba histolytica Ran family GTPase 0.0024 0.0062 0.0591
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.0531 0.0528
Toxoplasma gondii thioredoxin reductase 0.005 0.0198 0.0294
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.005 0.0198 0.0195
Schistosoma mansoni amine GPCR 0.0112 0.0531 0.0528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0104 0.0489 0.0486
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0031 0.0028
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0539 0.148
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0666 0.3494 0.3478
Brugia malayi nuclear receptor RXR 0.0021 0.0043 0.0043
Echinococcus multilocularis dnaJ subfamily B 0.043 0.2232 0.223
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0031 0.0031
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0133 0.0752
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0198 0.0195
Schistosoma mansoni glutamate receptor kainate 0.0053 0.0215 0.0212
Schistosoma mansoni glutamate receptor kainate 0.0024 0.0059 0.0056
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0047 0.0022
Echinococcus granulosus nervana 2 0.0016 0.002 0.0017
Echinococcus granulosus importin subunit beta 1 0.0033 0.0108 0.0105
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0141 0.0138
Echinococcus granulosus microtubule associated protein 2 0.1611 0.8549 0.8549
Schistosoma mansoni tar DNA-binding protein 0.0039 0.0143 0.014
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0539 0.4157
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0031 0.0028
Brugia malayi SH2 domain containing protein 0.0013 0.0003 0.0003
Schistosoma mansoni glutamate receptor NMDA 0.0024 0.0059 0.0056
Loa Loa (eye worm) hypothetical protein 0.0056 0.023 0.0227
Onchocerca volvulus 0.0104 0.0491 0.1812
Trichomonas vaginalis CMGC family protein kinase 0.004 0.0144 0.0826
Brugia malayi Serotonin receptor 0.0112 0.0531 0.0531
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0047 0.0497
Brugia malayi TAR-binding protein 0.0039 0.0143 0.0143
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Echinococcus multilocularis neuropeptide FF receptor 2 0.0112 0.0531 0.0528
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0118 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0141 0.0141
Echinococcus multilocularis rac serine:threonine kinase 0.0017 0.0024 0.002
Schistosoma mansoni lipoxygenase 0.0056 0.0232 0.0229
Trypanosoma brucei glycosyl hydrolase-like protein 0.0074 0.0327 0.0303
Onchocerca volvulus 0.002 0.0039 0.0135
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1883 1 1
Mycobacterium tuberculosis Conserved protein 0.0104 0.0491 0.1342
Echinococcus granulosus carboxylesterase 5A 0.0294 0.1504 0.1501
Echinococcus multilocularis fmrfamide receptor 0.0112 0.0531 0.0528
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.004 0.0144 0.012
Schistosoma mansoni zinc finger protein 0.0018 0.0031 0.0028
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Loa Loa (eye worm) beta-lactamase 0.0104 0.0491 0.0488
Schistosoma mansoni glutamate receptor kainate 0.0053 0.0215 0.0212
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0031 0.0028
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0075 0.0348
Echinococcus multilocularis neuroligin 0.005 0.0198 0.0195
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0039 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Echinococcus multilocularis survival motor neuron protein 1 0.0512 0.267 0.2667
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0057 0.0239 0.0236
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0112 0.0531 0.0531
Onchocerca volvulus 0.0112 0.0531 0.1962
Trichomonas vaginalis maltase-glucoamylase, putative 0.0198 0.0992 0.6693
Schistosoma mansoni carbonic anhydrase 0.1123 0.5935 0.5933
Trichomonas vaginalis alpha-glucosidase, putative 0.0198 0.0992 0.6693
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0112 0.0531 0.0531
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0021 0.0018
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0351 0.1807 0.1804
Mycobacterium tuberculosis Conserved protein 0.0104 0.0491 0.1342
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1123 0.5935 0.5935
Schistosoma mansoni hypothetical protein 0.0112 0.0531 0.0528
Schistosoma mansoni gliotactin 0.005 0.0198 0.0195
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0141 0.0138
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0057 0.0239 0.0236
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0133 0.011
Echinococcus multilocularis carbonic anhydrase 0.1123 0.5935 0.5933
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0104 0.0489 0.0489
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0141 0.0141
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.0489 0.0486
Schistosoma mansoni tar DNA-binding protein 0.0039 0.0143 0.014
Echinococcus granulosus glutamate receptor 2 0.0019 0.0036 0.0033
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0043 0.004
Brugia malayi hypothetical protein 0.0112 0.0531 0.0531
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0198 0.0992 0.0989
Brugia malayi hypothetical protein 0.0512 0.267 0.267
Loa Loa (eye worm) TAR-binding protein 0.0039 0.0143 0.014
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0094 0.0091
Entamoeba histolytica cell division protein kinase 2, putative 0.004 0.0144 0.1423
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0104 0.0491 0.0491
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0021 0.0021
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0133 0.0109
Schistosoma mansoni thyroid hormone receptor 0.0122 0.0586 0.0583
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0062 0.0037
Trypanosoma brucei carbonic anhydrase-like protein 0.1883 1 1
Plasmodium vivax glutathione reductase, putative 0.005 0.0198 0.3738
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0024 0.0018
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0074 0.0327 0.0304
Brugia malayi SRC-1 0.0013 0.0003 0.0003
Mycobacterium tuberculosis Probable esterase LipL 0.0104 0.0491 0.1342
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.0531 0.0528
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1883 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0047 0.0155
Onchocerca volvulus 0.0112 0.0531 0.1962
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0112 0.0531 0.0528
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0244 0.022
Schistosoma mansoni ran 0.0024 0.0062 0.0058
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0047 0.0044
Echinococcus granulosus tachykinin peptides receptor 99D 0.0112 0.0531 0.0528
Echinococcus multilocularis NMDA receptor 0.0038 0.0135 0.0132
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0539 0.148
Giardia lamblia Kinase, CMGC CDK 0.004 0.0144 1
Schistosoma mansoni glutaminase 0.0287 0.147 0.1467
Loa Loa (eye worm) hypothetical protein 0.0104 0.0491 0.0488
Brugia malayi beta-lactamase 0.0104 0.0491 0.0491
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.0001
Brugia malayi putative neuropeptide receptor NPR1 0.0112 0.0531 0.0531
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.0531 0.0528
Schistosoma mansoni carbonic anhydrase-related 0.1123 0.5935 0.5933
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0195
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0028
Schistosoma mansoni biogenic amine receptor 0.0112 0.0531 0.0528
Echinococcus multilocularis serotonin receptor 0.0112 0.0531 0.0528
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0666 0.3494 0.3479
Echinococcus multilocularis glutamate receptor 2 0.0028 0.0083 0.008
Schistosoma mansoni glutamate receptor NMDA 0.0028 0.0083 0.008
Schistosoma mansoni importin beta-1 0.0033 0.0108 0.0105
Echinococcus multilocularis cpg binding protein 0.0032 0.0103 0.01
Brugia malayi ecdysteroid receptor 0.0039 0.0141 0.0141
Onchocerca volvulus 0.0104 0.0491 0.1812
Echinococcus multilocularis para nitrobenzyl esterase 0.005 0.0198 0.0195
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0074 0.0327 0.3275
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0141 0.0138
Schistosoma mansoni carbonic anhydrase-related 0.1123 0.5935 0.5933
Brugia malayi ecdysone receptor 0.0018 0.0031 0.0031
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0133 0.013
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0047 1
Loa Loa (eye worm) hypothetical protein 0.0294 0.1504 0.1501
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0112 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0141 0.0138
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0047 0.0044
Schistosoma mansoni lamin 0.0056 0.023 0.0227
Loa Loa (eye worm) hypothetical protein 0.0104 0.0491 0.0488
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.004
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0195
Trichomonas vaginalis CMGC family protein kinase 0.004 0.0144 0.0826
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0112 0.0531 0.0528
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0141 0.0138
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0141 0.0138
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0069 0.0305
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0133 0.011
Schistosoma mansoni BC026374 protein (S09 family) 0.005 0.0198 0.0195
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0031 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0531 0.0528
Schistosoma mansoni lamin 0.0056 0.023 0.0227
Echinococcus granulosus intermediate filament protein 0.0056 0.023 0.0227
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.1123 0.5935 0.5933
Brugia malayi nuclear hormone receptor 0.0039 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0052 0.0213 0.021
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0104 0.0491 0.1342
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0141 0.0138
Schistosoma mansoni transcription factor LCR-F1 0.0118 0.0565 0.0562
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0021 0.0018
Echinococcus multilocularis nervana 2 0.0016 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0138
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0141 0.0138
Onchocerca volvulus 0.005 0.0198 0.0724
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0244 0.0631
Echinococcus granulosus survival motor neuron protein 1 0.0512 0.267 0.2667
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0047 0.0047
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0133 0.013
Echinococcus granulosus neuropeptides capa receptor 0.0112 0.0531 0.0528
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0141 0.0141
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0666 0.3494 0.3492
Onchocerca volvulus 0.0516 0.2693 1
Echinococcus multilocularis serotonin receptor 0.0112 0.0531 0.0528
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0028 0.0083 0.008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0112 0.0531 0.0528
Trypanosoma brucei cdc2-related kinase 3 0.004 0.0144 0.012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0141 0.0138
Brugia malayi nuclear receptor RXR 0.0018 0.0031 0.0031
Brugia malayi Glycosyl hydrolases family 31 protein 0.0198 0.0992 0.0992
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0038 0.0135 0.0132
Echinococcus multilocularis neutral alpha glucosidase AB 0.0198 0.0992 0.0989
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0141 0.0513
Entamoeba histolytica hypothetical protein 0.0118 0.0565 0.5685
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0024 0.0059 0.0056
Schistosoma mansoni hypothetical protein 0.002 0.0039 0.0036
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0244 0.1517
Echinococcus granulosus beta LACTamase domain containing family member 0.0104 0.0491 0.0488
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0028 0.0083 0.008
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0248 0.1257 0.2085
Echinococcus granulosus biogenic amine 5HT receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0195
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0047 0.0442
Brugia malayi Carboxylesterase family protein 0.005 0.0198 0.0198
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.0001
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Plasmodium falciparum glutathione reductase 0.005 0.0198 0.0295
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1883 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0112 0.0531 0.0531
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0141 0.0138
Schistosoma mansoni serine/threonine-protein kinase 0.0017 0.0024 0.002
Giardia lamblia Kinase, CMGC CDK 0.004 0.0144 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.004 0.0144 0.0202
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0141 0.0138
Onchocerca volvulus 0.0112 0.0531 0.1962
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0531 0.0528
Onchocerca volvulus 0.005 0.0198 0.0724
Brugia malayi Protein kinase domain containing protein 0.0013 0.0003 0.0003
Echinococcus granulosus snurportin 1 0.0351 0.1807 0.1804
Brugia malayi hypothetical protein 0.0112 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0056 0.0233 0.023
Leishmania major GTP-binding protein, putative 0.0024 0.0062 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0141 0.0141
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0141 0.0138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.0001
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0039 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0144 0.0141
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.0531 0.0528
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Echinococcus granulosus serine/threonine protein kinase 0.0017 0.0024 0.002
Brugia malayi steroid hormone receptor 0.0039 0.0141 0.0141
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0248 0.1257 0.1236
Schistosoma mansoni biogenic amine receptor 0.0112 0.0531 0.0528
Brugia malayi Doublecortin family protein 0.002 0.0039 0.0039
Brugia malayi hypothetical protein 0.0112 0.0531 0.0531
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0327 0.2093
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0083 0.0377 0.0374
Brugia malayi beta-lactamase family protein 0.0104 0.0491 0.0491
Mycobacterium ulcerans hypothetical protein 0.0104 0.0491 0.3226
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0083 0.0377 0.0374
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0069 0.0305
Brugia malayi protein-tyrosine kinase 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0108 0.0105
Echinococcus multilocularis cyclin dependent kinase 0.004 0.0144 0.0141
Echinococcus multilocularis musashi 0.0056 0.023 0.0227
Brugia malayi Pre-SET motif family protein 0.0035 0.0118 0.0118
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0057 0.0239 0.0236
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0104 0.0491 0.0488
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.0531 0.0528
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1883 1 1
Echinococcus granulosus glutamate NMDA receptor subunit 0.0024 0.0059 0.0056
Echinococcus granulosus tumor protein p63 0.0385 0.199 0.1987
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Schistosoma mansoni neuropeptide receptor 0.0112 0.0531 0.0528
Brugia malayi G-protein coupled receptor 0.0112 0.0531 0.0531
Echinococcus multilocularis carbonic anhydrase 0.1123 0.5935 0.5933
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0666 0.3494 0.3479
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0047 0.0064
Loa Loa (eye worm) hypothetical protein 0.0512 0.267 0.2667
Echinococcus granulosus tyrosine protein kinase Lyn 0.0014 0.0006 0.0003
Echinococcus granulosus fmrfamide receptor 0.0112 0.0531 0.0528
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1883 1 1
Loa Loa (eye worm) hypothetical protein 0.1123 0.5935 0.5933
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0141 0.0141
Onchocerca volvulus 0.0112 0.0531 0.1962
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0108 0.0141
Mycobacterium tuberculosis Carboxylesterase LipT 0.005 0.0198 0.0499
Echinococcus multilocularis nervana 2 0.0016 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0074 0.0327 0.0324
Loa Loa (eye worm) intermediate filament protein 0.0056 0.023 0.0227
Plasmodium falciparum thioredoxin reductase 0.005 0.0198 0.0295
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.0327 0.2093
Schistosoma mansoni glutamate receptor AMPA 0.0024 0.0059 0.0056
Brugia malayi Carboxylesterase family protein 0.005 0.0198 0.0198
Brugia malayi beta-lactamase family protein 0.0104 0.0491 0.0491
Entamoeba histolytica PH domain containing protein kinase, putative 0.0017 0.0024 0.0207
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0248 0.1257 0.1236
Trichomonas vaginalis set domain proteins, putative 0.027 0.1378 0.9369
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.004 0.0144 0.0141
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0039 0.0036
Mycobacterium ulcerans beta-lactamase 0.0104 0.0491 0.3226
Loa Loa (eye worm) neuropeptide F receptor 0.0112 0.0531 0.0528
Entamoeba histolytica hypothetical protein 0.0027 0.0075 0.0724
Schistosoma mansoni amine GPCR 0.0112 0.0531 0.0528
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0141 0.0138
Leishmania major trypanothione reductase 0.005 0.0198 0.0174
Mycobacterium ulcerans glutaminase 0.0287 0.147 1
Brugia malayi hypothetical protein 0.0112 0.0531 0.0531
Schistosoma mansoni hypothetical protein 0.0036 0.0124 0.0121
Schistosoma mansoni alpha-glucosidase 0.0768 0.4042 0.404
Loa Loa (eye worm) glutamate receptor 1 0.0024 0.0059 0.0056
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0043 0.004
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0112 0.0531 0.0531
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0141 0.0138
Echinococcus multilocularis beta LACTamase domain containing family member 0.0104 0.0491 0.0488
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0031 0.0031
Echinococcus granulosus GPCR family 2 0.0017 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Entamoeba histolytica hypothetical protein 0.0118 0.0565 0.5685
Echinococcus multilocularis lamin 0.0056 0.023 0.0227
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0028
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0233 0.023
Trypanosoma brucei cdc2-related kinase 1 0.004 0.0144 0.012
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0245 0.0373
Echinococcus multilocularis orexin receptor type 2 0.0112 0.0531 0.0528
Onchocerca volvulus 0.0112 0.0531 0.1962
Onchocerca volvulus 0.0039 0.0141 0.0513
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0141 0.0138
Echinococcus multilocularis RUN 0.002 0.0039 0.0036
Trichomonas vaginalis alpha-glucosidase, putative 0.0198 0.0992 0.6693
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0112 0.0531 0.0528
Loa Loa (eye worm) doublecortin family protein 0.002 0.0039 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0069 0.0305
Schistosoma mansoni ap endonuclease 0.0021 0.0047 0.0044
Echinococcus granulosus cpg binding protein 0.0032 0.0103 0.01
Brugia malayi hypothetical protein 0.0118 0.0565 0.0565
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0112 0.0531 0.0528
Brugia malayi intermediate filament protein 0.0056 0.023 0.023
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0198 0.0992 1
Echinococcus granulosus dro:myosuppressin receptor 0.0112 0.0531 0.0528
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0244 0.0241
Entamoeba histolytica hypothetical protein 0.0118 0.0565 0.5685
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0141 0.0138
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0133 0.9102
Schistosoma mansoni amine GPCR 0.0112 0.0531 0.0528
Echinococcus granulosus tm gpcr rhodopsin 0.0112 0.0531 0.0528
Trypanosoma cruzi cdc2-related kinase 3 0.004 0.0144 0.0121
Plasmodium falciparum protein kinase 5 0.004 0.0144 0.0203
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0531 0.0528
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0112 0.0531 0.0528
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0666 0.3494 0.3492
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0028
Brugia malayi Carboxylesterase family protein 0.005 0.0198 0.0198
Entamoeba histolytica hypothetical protein 0.0118 0.0565 0.5685
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.0607 0.1675
Brugia malayi hypothetical protein 0.002 0.0039 0.0039
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Brugia malayi larval opioid receptor 0.0112 0.0531 0.0531
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0031 0.0028
Brugia malayi hypothetical protein 0.002 0.0039 0.0039
Trichomonas vaginalis esterase, putative 0.0104 0.0491 0.3226
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0141 0.0141
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0118 0.0115
Trichomonas vaginalis spcc417.12 protein, putative 0.005 0.0198 0.12
Brugia malayi Protein kinase domain containing protein 0.004 0.0144 0.0144
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0112 0.0531 0.0528
Echinococcus granulosus sex peptide receptor 0.0112 0.0531 0.0528
Echinococcus granulosus g-protein coupled receptor 0.0112 0.0531 0.0528
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0043 0.004
Echinococcus multilocularis tar DNA binding protein 0.0039 0.0143 0.014
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Schistosoma mansoni hypothetical protein 0.0017 0.0021 0.0018
Schistosoma mansoni hypothetical protein 0.0017 0.0021 0.0018
Echinococcus multilocularis cyclin dependent kinase 1 0.004 0.0144 0.0141
Brugia malayi Serotonin receptor 0.0112 0.0531 0.0531
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0112 0.0531 0.0528
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0104 0.0491 0.1342
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.004
Schistosoma mansoni intermediate filament proteins 0.0056 0.023 0.0227
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1123 0.5935 0.5935
Mycobacterium ulcerans lipase LipD 0.0104 0.0491 0.3226
Schistosoma mansoni acetylcholinesterase 0.005 0.0198 0.0195
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.1203 0.12
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0531 0.0528
Echinococcus granulosus peptide allatostatin:somatostatin 0.0112 0.0531 0.0528
Onchocerca volvulus 0.0056 0.0233 0.0856
Onchocerca volvulus 0.0104 0.0491 0.1812
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0069 0.0305
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0141 0.0138
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0075 0.0051
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0024 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0138
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0112 0.0531 0.0528
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0141 0.0138
Onchocerca volvulus 0.0112 0.0531 0.1962
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0074 0.0327 0.1203
Schistosoma mansoni hypothetical protein 0.0351 0.1807 0.1804
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0539 0.148
Schistosoma mansoni adenoreceptor 0.0112 0.0531 0.0528
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0118 0.0115
Toxoplasma gondii fructose-bisphospatase I 0.0248 0.1257 0.2085
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0112 0.0531 0.0528
Trypanosoma cruzi cdc2-related kinase 1 0.004 0.0144 0.0121
Schistosoma mansoni neuropeptide f receptor 76f 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0138
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0112 0.0531 0.0528
Echinococcus granulosus g protein coupled receptor 0.0112 0.0531 0.0528
Schistosoma mansoni survival motor neuron protein 0.0104 0.0491 0.0488
Trichomonas vaginalis maltase-glucoamylase, putative 0.0074 0.0327 0.2093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.0531 0.0528
Echinococcus granulosus carbonic anhydrase 0.1123 0.5935 0.5933
Loa Loa (eye worm) glutamate receptor 2 0.0024 0.0059 0.0056
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0232 0.0229
Echinococcus granulosus hypothetical protein 0.0112 0.0531 0.0528
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0039 0.0036
Schistosoma mansoni ran 0.0024 0.0062 0.0058
Brugia malayi glutathione reductase 0.005 0.0198 0.0198
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0124 0.0124
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0031 0.0028
Echinococcus multilocularis glutamate receptor 2 0.0019 0.0036 0.0033
Schistosoma mansoni rab6-interacting 0.002 0.0039 0.0036
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0031 0.0031
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0327 0.2093
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0244 0.0241
Brugia malayi Glycosyl hydrolases family 31 protein 0.0074 0.0327 0.0327
Echinococcus granulosus neuropeptide s receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0104 0.0491 0.0488
Plasmodium vivax protein kinase Crk2 0.004 0.0144 0.2575
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0108 0.0084
Schistosoma mansoni cpg binding protein 0.003 0.0094 0.0091
Trichomonas vaginalis D-aminoacylase, putative 0.0104 0.0491 0.3226
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0024 0.0001
Echinococcus granulosus neuropeptide receptor 0.0112 0.0531 0.0528
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0104 0.0491 0.1342
Echinococcus granulosus rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0031 0.0028
Schistosoma mansoni amine GPCR 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Schistosoma mansoni alpha-1 adrenergic receptor 0.0112 0.0531 0.0528
Mycobacterium tuberculosis Conserved protein 0.0104 0.0491 0.1342
Schistosoma mansoni cpg binding protein 0.0032 0.0103 0.01
Schistosoma mansoni hypothetical protein 0.0112 0.0531 0.0528
Brugia malayi neuropeptide F receptor 0.0112 0.0531 0.0531
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0327 0.2093
Leishmania major hypothetical protein, conserved 0.0104 0.0491 0.0467
Echinococcus multilocularis cyclin dependent kinase 1 0.004 0.0144 0.0141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.0489 0.0486
Schistosoma mansoni hypothetical protein 0.0112 0.0531 0.0528
Brugia malayi G protein-coupled receptor 0.0112 0.0531 0.0531
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0043 0.004
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0047 0.1932
Echinococcus granulosus lamin dm0 0.0056 0.023 0.0227
Plasmodium vivax importin-beta 2, putative 0.0033 0.0108 0.1805
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0141 0.0138
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0047 0.0023
Plasmodium falciparum thioredoxin reductase 0.0017 0.0024 0.0001
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0198 0.0195
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0031 0.0028
Schistosoma mansoni nuclear receptor 0.0018 0.0031 0.0028
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Onchocerca volvulus 0.0112 0.0531 0.1962
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Brugia malayi hypothetical protein 0.0112 0.0531 0.0531
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0133 0.013
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0112 0.0531 0.0528
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0047 0.0039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.0001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.0327 0.2093
Loa Loa (eye worm) glutaminase 0.0287 0.147 0.1467
Loa Loa (eye worm) G-protein coupled receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) carboxylesterase 0.005 0.0198 0.0195
Schistosoma mansoni polycystin 1-related 0.002 0.0039 0.0036
Echinococcus multilocularis g protein coupled receptor 0.0112 0.0531 0.0528
Toxoplasma gondii fructose-bisphospatase II 0.0666 0.3494 0.587
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Brugia malayi RNA, U transporter 1 0.0093 0.0432 0.0432
Schistosoma mansoni coup transcription factor 0.0039 0.0141 0.0138
Brugia malayi Carboxylesterase family protein 0.0294 0.1504 0.1504
Schistosoma mansoni tar DNA-binding protein 0.0039 0.0143 0.014
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.0607 0.1675
Brugia malayi hypothetical protein 0.0112 0.0531 0.0531
Toxoplasma gondii hypothetical protein 0.1123 0.5935 1
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0666 0.3494 0.3492
Echinococcus multilocularis GPCR, family 2 0.0017 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0327 0.2093
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0092 0.0089
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0141 0.0138
Echinococcus multilocularis thyroid hormone receptor alpha 0.0122 0.0586 0.0583
Loa Loa (eye worm) AGC/AKT protein kinase 0.0025 0.0069 0.0065
Trypanosoma brucei glucosidase, putative 0.0198 0.0992 0.097
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0024 0.0021
Echinococcus granulosus serotonin receptor 0.0112 0.0531 0.0528
Trichomonas vaginalis alpha-glucosidase, putative 0.0198 0.0992 0.6693
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0198 0.3738
Brugia malayi Glycosyl hydrolases family 31 protein 0.0893 0.4706 0.4706
Brugia malayi hypothetical protein 0.0021 0.0043 0.0043
Brugia malayi Pre-SET motif family protein 0.0238 0.1203 0.1203
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0112 0.0531 0.0528
Onchocerca volvulus 0.0018 0.0031 0.0103
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0104 0.0491 0.0488
Plasmodium vivax SET domain protein, putative 0.0035 0.0118 0.2013
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0104 0.0489 0.0486
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0024 0.0024
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0141 0.0138
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.0607 0.1675
Brugia malayi nuclear receptor NHR-88 0.0039 0.0141 0.0141
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0062 0.3155
Echinococcus granulosus neuropeptide Y receptor 0.0112 0.0531 0.0528
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0144 0.0141
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0112 0.0531 0.0528
Schistosoma mansoni hypothetical protein 0.0104 0.0491 0.0488
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Brugia malayi Carboxylesterase family protein 0.005 0.0198 0.0198
Trypanosoma cruzi cdc2-related kinase 3 0.004 0.0144 0.0121
Brugia malayi Protein kinase domain containing protein 0.0013 0.0003 0.0003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0141 0.0138
Loa Loa (eye worm) hypothetical protein 0.1123 0.5935 0.5933
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0028
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0062 0.0063
Toxoplasma gondii AGC kinase 0.0025 0.0069 0.0075
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0138
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0062 0.0038
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Entamoeba histolytica protein kinase, putative 0.0025 0.0069 0.0661
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0141 0.0141
Brugia malayi Melatonin receptor type 1A 0.0112 0.0531 0.0531
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0141 0.0138
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Onchocerca volvulus 0.0112 0.0531 0.1962
Brugia malayi putative neuropeptide receptor 0.0112 0.0531 0.0531
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0118 0.0115
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0138
Trichomonas vaginalis penicillin-binding protein, putative 0.0104 0.0491 0.3226
Brugia malayi hypothetical protein 0.0018 0.0031 0.0031
Schistosoma mansoni loxhd1 0.002 0.0039 0.0036
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0038 0.0135 0.0132
Trichomonas vaginalis sucrase-isomaltase, putative 0.0198 0.0992 0.6693
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0028
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0104 0.0491 0.0488
Schistosoma mansoni nuclear receptor 0.0018 0.0031 0.0028
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0112 0.0531 0.0528
Schistosoma mansoni biogenic amine (5HT) receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Schistosoma mansoni neuroligin 3 (S09 family) 0.005 0.0198 0.0195
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0031 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0141 0.0138
Trichomonas vaginalis D-aminoacylase, putative 0.0104 0.0491 0.3226
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1123 0.5935 0.5935
Brugia malayi nuclear receptor NHR-67 0.0018 0.0031 0.0031
Echinococcus multilocularis g protein coupled receptor 0.0112 0.0531 0.0528
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0108 0.0105
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0133 0.0109
Schistosoma mansoni opsin-like receptor 0.0112 0.0531 0.0528
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0141 0.0141
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0074 0.0327 0.0304
Schistosoma mansoni histamine h1 receptor 0.0112 0.0531 0.0528
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0198 0.0195
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0112 0.0531 0.0528
Echinococcus multilocularis g-protein coupled receptor 0.0112 0.0531 0.0528
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0104 0.0489 0.0486
Onchocerca volvulus 0.0112 0.0531 0.1962
Trypanosoma cruzi hypothetical protein, conserved 0.0198 0.0992 0.097
Brugia malayi Protein kinase domain containing protein 0.0013 0.0003 0.0003
Echinococcus granulosus BC026374 protein S09 family 0.005 0.0198 0.0195
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0195
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Echinococcus multilocularis allatostatin A receptor 0.0112 0.0531 0.0528
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0112 0.0531 0.0528
Schistosoma mansoni opsin-like receptor 0.0112 0.0531 0.0528
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0118 0.0115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0112 0.0531 0.0528
Loa Loa (eye worm) TYRA-2 protein 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0138
Schistosoma mansoni tyrosine kinase 0.0013 0.0003 0.0000000076168
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0062 0.0812
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0062 0.0058
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0893 0.4706 0.4705
Brugia malayi Dopamine receptor protein 1 0.0112 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.005 0.0198 0.0195
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0141 0.0138
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.004 0.0144 0.0141
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0141 0.0138
Schistosoma mansoni neuropeptide receptor 0.0112 0.0531 0.0528
Brugia malayi tailless protein 0.0018 0.0031 0.0031
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0021 0.0018
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.004 0.0144 0.0141
Echinococcus granulosus carbonic anhydrase 0.1123 0.5935 0.5933
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0021 0.0021
Trypanosoma cruzi cdc2-related kinase 1 0.004 0.0144 0.0121
Schistosoma mansoni neuropeptide F-like receptor 0.0112 0.0531 0.0528
Trichomonas vaginalis alpha-glucosidase, putative 0.0198 0.0992 0.6693
Plasmodium falciparum glutathione reductase 0.0017 0.0024 0.0001
Echinococcus granulosus para nitrobenzyl esterase 0.005 0.0198 0.0195
Onchocerca volvulus 0.0056 0.023 0.0843
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.004
Echinococcus granulosus cyclin dependent kinase 5 0.004 0.0144 0.0141
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0043 0.004
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0539 0.148
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0047 0.0044
Echinococcus multilocularis G-protein coupled receptor, putative 0.0112 0.0531 0.0528
Mycobacterium tuberculosis Probable lipase LipE 0.0104 0.0491 0.1342
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0024 0.0071
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.005 0.0198 0.0499
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0028
Mycobacterium tuberculosis Probable hydrolase 0.0104 0.0491 0.1342
Onchocerca volvulus 0.002 0.0039 0.0135
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0038 0.0135 0.0132
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0031 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0141 0.0138
Echinococcus multilocularis neuropeptide Y receptor 0.0112 0.0531 0.0528
Brugia malayi p70 ribosomal S6 kinase beta 0.0025 0.0069 0.0069
Onchocerca volvulus 0.0112 0.0531 0.1962
Brugia malayi Thioredoxin reductase 0.005 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0104 0.0491 0.0488
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0039 0.0036
Onchocerca volvulus Neuropeptide F receptor homolog 0.0112 0.0531 0.1962
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0118 0.0565 0.0562
Trichomonas vaginalis CMGC family protein kinase 0.004 0.0144 0.0826
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0133 0.013
Loa Loa (eye worm) carbonic anhydrase 3 0.1883 1 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0062 0.0064
Trypanosoma brucei hypothetical protein, conserved 0.0104 0.0491 0.0467
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0028
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0141 0.0138
Brugia malayi Dopamine receptor 0.0112 0.0531 0.0531
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0112 0.0531 0.0528
Schistosoma mansoni neuropeptide receptor 0.0112 0.0531 0.0528
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Onchocerca volvulus 0.005 0.0198 0.0724
Entamoeba histolytica protein kinase, putative 0.0025 0.0069 0.0661
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0491 0.0491
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.023 0.023
Brugia malayi G-protein coupled receptor 0.0112 0.0531 0.0531
Brugia malayi nuclear hormone receptor 0.0018 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0138
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0031 0.0028
Echinococcus granulosus alpha 1A adrenergic receptor 0.0112 0.0531 0.0528
Echinococcus multilocularis snurportin 1 0.0351 0.1807 0.1804
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0141 0.0141
Echinococcus multilocularis neuropeptide s receptor 0.0112 0.0531 0.0528
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0133 0.013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0018
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0031 0.0028
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0112 0.0531 0.0528
Trichomonas vaginalis ran, putative 0.0024 0.0062 0.0257
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0112 0.0531 0.0528
Echinococcus multilocularis cyclin dependent kinase 5 0.004 0.0144 0.0141
Onchocerca volvulus 0.0104 0.0491 0.1812
Schistosoma mansoni glutamate receptor AMPA 0.0024 0.0059 0.0056
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.005 0.0198 0.0195
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0539 0.148
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0112 0.0531 0.0528
Plasmodium vivax hypothetical protein, conserved 0.0104 0.0491 1
Echinococcus granulosus tm gpcr rhodopsin 0.0737 0.3873 0.3871
Leishmania major 0.0666 0.3494 0.3478
Entamoeba histolytica PH domain containing protein kinase, putative 0.0017 0.0024 0.0207
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0024 0.0001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0112 0.0531 0.0528
Onchocerca volvulus 0.0112 0.0531 0.1962
Trichomonas vaginalis AGC family protein kinase 0.0025 0.0069 0.0305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0024 0.0001
Echinococcus multilocularis neuropeptide receptor A26 0.0112 0.0531 0.0528
Toxoplasma gondii ABC1 family protein 0.0104 0.0491 0.0789
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0141 0.0141
Echinococcus granulosus RUN 0.002 0.0039 0.0036
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0043 0.0043
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0112 0.0531 0.1962
Schistosoma mansoni myosin xvIII 0.0112 0.0531 0.0528
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0133 0.1314
Onchocerca volvulus 0.003 0.0094 0.0337
Schistosoma mansoni cpg binding protein 0.0032 0.0103 0.01
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0024 0.0001
Plasmodium falciparum carbonic anhydrase 0.1123 0.5935 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0043 0.0043
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0031 0.0031
Echinococcus multilocularis tumor protein p63 0.0385 0.199 0.1987
Trypanosoma cruzi hypothetical protein, conserved 0.0104 0.0491 0.0468
Echinococcus granulosus neuroligin 0.005 0.0198 0.0195
Trypanosoma cruzi hypothetical protein, conserved 0.0104 0.0491 0.0468
Brugia malayi SH2 domain containing protein 0.0013 0.0003 0.0003
Mycobacterium tuberculosis Probable reductase 0.0113 0.0539 0.148
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0031 0.0028
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0133 0.013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0141 0.0138
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0047 0.0023
Loa Loa (eye worm) acetylcholinesterase 1 0.0294 0.1504 0.1501
Schistosoma mansoni opsin-like receptor 0.0112 0.0531 0.0528
Echinococcus multilocularis g protein coupled receptor 0.0112 0.0531 0.0528
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0057 0.0239 0.0236
Echinococcus granulosus glutamate receptor 2 0.0028 0.0083 0.008

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 1000 nM Displacement of [3H]DAMGO from mouse whole brain MOR ChEMBL. 25248680
Ki (binding) > 1000 nM Displacement of [3H]DPDPE from mouse whole brain DOR ChEMBL. 25248680
Ki (binding) > 1000 nM Displacement of [3H]U-69593 from guinea pig cerebellum KOR ChEMBL. 25248680

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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