Detailed information for compound 992484

Basic information

Technical information
  • TDR Targets ID: 992484
  • Name: 4H-furo[2,3-d]pyrrole-5-carboxylic acid
  • MW: 151.119 | Formula: C7H5NO3
  • H donors: 2 H acceptors: 2 LogP: 1.06 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cc2c([nH]1)cco2
  • InChi: 1S/C7H5NO3/c9-7(10)5-3-6-4(8-5)1-2-11-6/h1-3,8H,(H,9,10)
  • InChiKey: MMAIBGHDBYQYDI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 67268-37-5
  • 4H-Furo[3,2-b]pyrrole-5-carboxylic acid
  • FS000697

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens D-aspartate oxidase Starlite/ChEMBL References
Homo sapiens D-amino-acid oxidase Starlite/ChEMBL References
Bos taurus D-aspartate oxidase Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL References
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References
Rattus norvegicus D-amino-acid oxidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans D-amino acid oxidase Aao Get druggable targets OG5_127583 All targets in OG5_127583
Candida albicans D-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao Get druggable targets OG5_127583 All targets in OG5_127583
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans putative d-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Candida albicans D-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Schistosoma mansoni d-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO Get druggable targets OG5_127583 All targets in OG5_127583
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K00272 D-aspartate oxidase [EC1.4.3.1], putative Get druggable targets OG5_127583 All targets in OG5_127583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127583 All targets in OG5_127583
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans putative d-amino acid oxidase Get druggable targets OG5_127583 All targets in OG5_127583
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans D-amino acid oxidase Aao D-amino-acid oxidase   346 aa 382 aa 24.1 %
Mycobacterium ulcerans D-amino acid oxidase Aao D-amino-acid oxidase 347 aa 378 aa 24.6 %
Mycobacterium ulcerans D-amino acid oxidase Aao D-aspartate oxidase 369 aa 373 aa 28.7 %
Candida albicans similar to putative d-amino acid oxidase D-amino-acid oxidase   346 aa 388 aa 22.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Onchocerca volvulus Unconventional prefoldin RPB5 interactor 1 homolog D-amino-acid oxidase   346 aa 350 aa 31.1 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0165 0.054
Schistosoma mansoni hypothetical protein 0.0145 0.0494 0.1683
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0065 0.0214
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0079 0.0662
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0087 0.0087
Leishmania major mitochondrial DNA polymerase beta 0.0306 0.1111 1
Echinococcus granulosus neuropeptide receptor A26 0.1478 0.5625 1
Schistosoma mansoni glutaminase 0.058 0.2167 0.7385
Brugia malayi steroid hormone receptor 0.0034 0.0065 0.0214
Onchocerca volvulus 0.006 0.0165 0.052
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0122 0.0415
Leishmania major trypanothione reductase 0.0049 0.0123 0.1111
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0065 0.0185 0.1662
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0069 0.0202 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0065 0.0214
Brugia malayi intermediate filament protein 0.0082 0.0251 0.0822
Loa Loa (eye worm) nuclear factor I 0.0019 0.0006 0.0019
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0036 0.0121
Echinococcus multilocularis lamin 0.0082 0.0251 0.0251
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0416 0.1535 0.503
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0491 0.4423
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0065 0.0185 0.1662
Trichomonas vaginalis glucosylceramidase, putative 0.081 0.3051 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0065 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0065 0.0116
Plasmodium vivax SET domain protein, putative 0.0061 0.0168 0.9121
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0459 0.1702 0.5579
Loa Loa (eye worm) hypothetical protein 0.0779 0.2934 0.9617
Brugia malayi MH1 domain containing protein 0.0033 0.0064 0.0208
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0491 0.0873
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0079 0.014
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0000081325 0.0001
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0018 0.0058
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.007 0.0125
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0145 0.0494 0.1619
Schistosoma mansoni hypothetical protein 0.0145 0.0494 0.1683
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0079 0.071
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0004 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0431 0.1469
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0365 0.1361
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0065 0.0214
Brugia malayi latrophilin 2 splice variant baaae 0.0314 0.1143 0.3746
Loa Loa (eye worm) hypothetical protein 0.0038 0.0081 0.0267
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0365 0.1361
Loa Loa (eye worm) hypothetical protein 0.005 0.0128 0.042
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0402 1
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0065 0.0185 0.1662
Loa Loa (eye worm) hypothetical protein 0.0052 0.0134 0.0439
Brugia malayi hypothetical protein 0.0248 0.0888 0.2911
Loa Loa (eye worm) hypothetical protein 0.0034 0.0065 0.0214
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0123 0.0123
Echinococcus granulosus cpg binding protein 0.0065 0.0185 0.0329
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0064 0.0238
Trichomonas vaginalis glucosylceramidase, putative 0.081 0.3051 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0065 0.0222
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0065 0.0214
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0064 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0491 0.0491
Loa Loa (eye worm) Smad1 0.0033 0.0064 0.0208
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0714 0.2684 1
Toxoplasma gondii thioredoxin reductase 0.0049 0.0123 0.307
Echinococcus multilocularis Smad4 0.0033 0.0064 0.0064
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.0496 0.0882
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0065 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0065 0.0214
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0114 0.0372
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0064 0.0208
Loa Loa (eye worm) hypothetical protein 0.0034 0.0065 0.0214
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.0521 0.1777
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0000081325 0.0001
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0065 0.0214
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0000081325 0.0001
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0064 0.0113
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0075 0.0075
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0123 0.046
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0065 0.0185 0.1662
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0041 0.0367
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.0491 0.4423
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0065 0.0116
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0168 0.0168
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0064 0.0113
Trichomonas vaginalis set domain proteins, putative 0.0473 0.1755 0.5752
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0065 0.0065
Schistosoma mansoni smad1 5 8 and 0.0033 0.0064 0.0216
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.0413 0.154
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0133 0.12
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0145 0.0494 0.0494
Brugia malayi MH2 domain containing protein 0.0033 0.0064 0.0208
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0024 0.0042
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0065 0.0222
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0065 0.0185 0.0629
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0104 0.0341
Echinococcus multilocularis GPCR, family 2 0.0145 0.0494 0.0494
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0065 0.0185 0.0629
Schistosoma mansoni cpg binding protein 0.0065 0.0185 0.0631
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0000081325 0.0001
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0065 0.0116
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.081 0.3051 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0095 0.0311
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0000081325 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0175 0.0573
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1979 0.6488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0491 0.1674
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0129 0.0423
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0041 0.0367
Mycobacterium tuberculosis Probable reductase 0.0112 0.0365 0.1361
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0065 0.0222
Loa Loa (eye worm) glutaminase 2 0.058 0.2167 0.7103
Loa Loa (eye worm) hypothetical protein 0.0145 0.0494 0.1619
Brugia malayi Bromodomain containing protein 0.0042 0.0098 0.0321
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0123 0.1111
Schistosoma mansoni cpg binding protein 0.0065 0.0185 0.0631
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0122 0.0415
Loa Loa (eye worm) transcription factor SMAD2 0.0491 0.1826 0.5985
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.0888 0.0888
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0065 0.0214
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0133 0.7214
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0065 0.0185 0.0629
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0065 0.0116
Brugia malayi nuclear receptor NHR-88 0.0034 0.0065 0.0214
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.0521 0.1709
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0192 0.0654
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0079 0.071
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0065 0.0214
Onchocerca volvulus Putative fad oxidoreductase 0.0065 0.0185 0.0624
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0114 0.6155
Brugia malayi Inositol-1 0.0037 0.0079 0.0259
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0065 0.0185 0.1662
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0036 0.0036
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0065 0.0065
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1979 0.6488
Loa Loa (eye worm) hypothetical protein 0.004 0.0087 0.0286
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0192 0.1727
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0065 0.0185 0.1662
Brugia malayi PHD-finger family protein 0.0032 0.0059 0.0193
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0000081325 0.0001
Schistosoma mansoni hypothetical protein 0.0051 0.0129 0.044
Brugia malayi hypothetical protein 0.0033 0.0063 0.0206
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0194 0.0346
Echinococcus granulosus dnaJ subfamily B 0.0428 0.1584 0.2816
Schistosoma mansoni smad1 5 8 and 0.0033 0.0064 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0065 0.0214
Loa Loa (eye worm) inositol-1 0.0037 0.0079 0.0259
Chlamydia trachomatis D-amino acid dehydrogenase 0.0065 0.0185 1
Schistosoma mansoni Smad4 0.0033 0.0064 0.0216
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0491 0.1674
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0251 0.0822
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.0888 0.1579
Schistosoma mansoni hypothetical protein 0.0428 0.1584 0.5398
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0168 0.4188
Brugia malayi glutathione reductase 0.0049 0.0123 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0065 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0065 0.0214
Loa Loa (eye worm) hypothetical protein 0.0065 0.0185 0.0605
Loa Loa (eye worm) glutaminase 0.058 0.2167 0.7103
Brugia malayi Pre-SET motif family protein 0.0061 0.0168 0.0552
Schistosoma mansoni inositol monophosphatase 0.0037 0.0079 0.0269
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.01 0.0901
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0065 0.0185 0.0624
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0104 0.0341
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0000081325 0.0001
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0065 0.0185 0.0605
Schistosoma mansoni hypothetical protein 0.0021 0.0015 0.0051
Loa Loa (eye worm) hypothetical protein 0.0081 0.0245 0.0803
Schistosoma mansoni d-amino acid oxidase 0.0779 0.2934 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0155 0.0276
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0000081325 0.0001
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.01 0.0901
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0065 0.0185 0.4592
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0064 0.0064
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0065 0.0214
Brugia malayi Calcitonin receptor-like protein seb-1 0.0459 0.1702 0.5579
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0001 0.0001
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0041 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0065 0.0214
Loa Loa (eye worm) acetyltransferase 0.0152 0.0521 0.1709
Brugia malayi Latrophilin receptor protein 2 0.0145 0.0494 0.1619
Echinococcus granulosus intermediate filament protein 0.0082 0.0251 0.0446
Schistosoma mansoni smad1 5 8 and 0.0033 0.0064 0.0216
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0133 0.12
Brugia malayi hypothetical protein 0.0018 0.0004 0.0012
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0065 0.0214
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0123 0.0219
Brugia malayi hypothetical protein 0.0052 0.0133 0.0437
Echinococcus multilocularis smad 0.0033 0.0064 0.0064
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0133 0.7214
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1979 0.6488
Loa Loa (eye worm) hypothetical protein 0.0039 0.0083 0.0274
Echinococcus multilocularis neuropeptide s receptor 0.1478 0.5625 0.5625
Schistosoma mansoni zinc finger protein 0.0027 0.0038 0.013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0065 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1979 0.6488
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0065 0.0185 0.1662
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0168 0.0574
Schistosoma mansoni hypothetical protein 0.0501 0.1864 0.6353
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.007 0.0239
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0114 0.0372
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0235 0.08
Toxoplasma gondii hypothetical protein 0.0065 0.0185 0.4592
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.081 0.3051 1
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0133 0.7214
Loa Loa (eye worm) latrophilin receptor protein 2 0.0145 0.0494 0.1619
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0136 0.1226
Schistosoma mansoni lamin 0.0082 0.0251 0.0855
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.0554 0.2065
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0248 0.0888 0.2911
Schistosoma mansoni survival motor neuron protein 0.0051 0.0129 0.044
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0065 0.0222
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0021 0.0068
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0065 0.0116
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0192 0.0654
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0038 0.0081 0.0267
Loa Loa (eye worm) hypothetical protein 0.0045 0.0107 0.0352
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0004 0.0012
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0000081325 0.0001
Plasmodium falciparum thioredoxin reductase 0.0049 0.0123 0.6683
Brugia malayi MH1 domain containing protein 0.0019 0.0006 0.0019
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0065 0.0185 0.0629
Echinococcus granulosus lamin 0.0082 0.0251 0.0446
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.007 0.007
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0000081325 0.0002
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0065 0.0185 0.0185
Schistosoma mansoni coup transcription factor 0.0034 0.0065 0.0222
Brugia malayi cDNA sequence BC016226 0.0065 0.0185 0.0605
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0079 0.0079
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0087 0.0155
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.0491 0.161
Onchocerca volvulus Glucosylceramidase homolog 0.0531 0.1979 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0114 0.2827
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0192 0.0341
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0065 0.0185 0.0605
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0065 0.0185 0.0629
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0145 0.0494 0.0878
Leishmania major cytochrome p450-like protein 0.0028 0.0041 0.0367
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0123 0.6683
Brugia malayi Pre-SET motif family protein 0.0416 0.1535 0.503
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0004 0.0012
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.0491 0.161
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0065 0.0185 0.1662
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0065 0.0065
Echinococcus multilocularis lamin dm0 0.0082 0.0251 0.0251
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0000081325 0.0001
Echinococcus multilocularis geminin 0.0501 0.1864 0.1864
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0078 0.0235 0.077
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0078 0.0235 0.0235
Echinococcus multilocularis cpg binding protein 0.0065 0.0185 0.0185
Leishmania major hypothetical protein, conserved 0.0052 0.0133 0.12
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0065 0.0185 0.1662
Loa Loa (eye worm) hypothetical protein 0.0034 0.0065 0.0214
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.1111 1
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0192 0.0654
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1979 0.6488
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.01 0.0901
Echinococcus granulosus neuropeptide s receptor 0.1478 0.5625 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0079 0.0269
Schistosoma mansoni fad oxidoreductase 0.0065 0.0185 0.0629
Trichomonas vaginalis glucosylceramidase, putative 0.081 0.3051 1
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0065 0.0185 0.0328
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.01 0.0901
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0000081325 0.0001
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0106 0.0348
Echinococcus multilocularis zinc finger protein 0.0027 0.0038 0.0038
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0065 0.0185 0.0328
Onchocerca volvulus 0.0082 0.0251 0.097
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0041 0.0139
Trypanosoma brucei trypanothione reductase 0.0049 0.0123 0.1111
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.009 0.4469
Trichomonas vaginalis glucosylceramidase, putative 0.081 0.3051 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Brugia malayi CXXC zinc finger family protein 0.006 0.0165 0.054
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0065 0.0185 0.0688
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0482 0.1789 0.5864
Plasmodium falciparum glutathione reductase 0.0049 0.0123 0.6683
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0064 0.0216
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0079 0.0258
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0065 0.0065
Echinococcus multilocularis tumor protein p63 0.0354 0.1297 0.1297
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0065 0.0185 0.0629
Schistosoma mansoni bromodomain containing protein 0.0071 0.0208 0.071
Echinococcus granulosus tumor protein p63 0.0354 0.1297 0.2306
Loa Loa (eye worm) hypothetical protein 0.0065 0.0185 0.0605
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0065 0.0185 0.1662
Loa Loa (eye worm) hypothetical protein 0.0065 0.0185 0.0605
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0192 0.0654
Loa Loa (eye worm) hypothetical protein 0.0082 0.0251 0.0822
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0004 0.0012
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0004 0.0004
Brugia malayi Smad1 0.0033 0.0064 0.0208
Onchocerca volvulus 0.0473 0.1755 0.8828
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0015 0.0049
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0079 0.071
Mycobacterium ulcerans glutaminase 0.058 0.2167 0.7385
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0365 0.1361
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0251 0.0822
Brugia malayi follicle stimulating hormone receptor 0.0482 0.1789 0.5864
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0041 0.0133
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0000081325 0.0001
Brugia malayi MH1 domain containing protein 0.0033 0.0064 0.0208
Brugia malayi RE18450p 0.0065 0.0185 0.0605
Echinococcus granulosus smad 0.0033 0.0064 0.0113
Brugia malayi MH2 domain containing protein 0.0033 0.0064 0.0208
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0065 0.0222
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0065 0.0185 0.0629
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0079 0.0258
Trichomonas vaginalis glucosylceramidase, putative 0.081 0.3051 1
Toxoplasma gondii hypothetical protein 0.0049 0.0124 0.3092
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0106 0.0348
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0106 0.0106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0000081325 0.0001
Schistosoma mansoni NAD dehydrogenase 0.0065 0.0185 0.0629
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0000081325 0.0001
Brugia malayi Cytochrome P450 family protein 0.0062 0.0175 0.0573
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0065 0.0185 0.0624
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0012
Schistosoma mansoni fad oxidoreductase 0.0065 0.0185 0.0629
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0065 0.0222
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0065 0.0185 1
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0065 0.0185 0.0605
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0192 0.4771
Schistosoma mansoni smad 0.0033 0.0064 0.0216
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.1111 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0065 0.0116
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0065 0.0185 0.1662
Loa Loa (eye worm) hypothetical protein 0.0314 0.1143 0.3746
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.009 0.1531
Brugia malayi ecdysteroid receptor 0.0034 0.0065 0.0214
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0133 0.3313
Loa Loa (eye worm) hypothetical protein 0.0039 0.0084 0.0276
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0079 0.1961
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0019
Schistosoma mansoni hypothetical protein 0.0501 0.1864 0.6353
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0069 0.0202 1
Echinococcus granulosus zinc finger protein 0.0027 0.0038 0.0068
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0065 0.0214
Echinococcus multilocularis musashi 0.0082 0.0251 0.0251
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0134 0.0457
Echinococcus granulosus Smad4 0.0033 0.0064 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0065 0.0214
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0065 0.0185 0.8683
Onchocerca volvulus 0.0051 0.0129 0.0334
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0079 1
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0004 0.0012
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0014 0.0047
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0251 0.0822
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0079 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0065 0.0214
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0065 0.0222
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0000081325 0.0001
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0079 0.0269
Brugia malayi glutaminase DH11.1 0.058 0.2167 0.7103
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0065 0.0214
Onchocerca volvulus 0.0061 0.0168 0.054
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1979 0.6488
Brugia malayi hypothetical protein 0.0035 0.007 0.023
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0065 0.0214
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0065 0.0065
Trichomonas vaginalis glutaminase, putative 0.058 0.2167 0.7102
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0065 0.0116
Brugia malayi hypothetical protein 0.0018 0.0004 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.0491 0.0491
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0041 0.0133
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0065 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0168 0.0574
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0145 0.0494 0.0878
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0065 0.0214
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0065 0.0222
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0065 0.0185 0.0185
Brugia malayi Bromodomain containing protein 0.0083 0.0254 0.0833
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0065 0.0065
Loa Loa (eye worm) glutathione reductase 0.0049 0.0123 0.0405
Loa Loa (eye worm) hypothetical protein 0.0034 0.0065 0.0214
Schistosoma mansoni hypothetical protein 0.0023 0.0024 0.0081
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0065 0.0222
Echinococcus granulosus GPCR family 2 0.0145 0.0494 0.0878
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.0491 0.4423
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0065 0.0185 0.1662
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0075 0.0133
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0065 0.0185 0.1662
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0064 0.0217
Echinococcus granulosus lamin dm0 0.0082 0.0251 0.0446
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0114 0.0202
Loa Loa (eye worm) hypothetical protein 0.0034 0.0065 0.0214
Loa Loa (eye worm) hypothetical protein 0.0459 0.1702 0.5579
Loa Loa (eye worm) MH2 domain-containing protein 0.0491 0.1826 0.5985
Schistosoma mansoni intermediate filament proteins 0.0082 0.0251 0.0855
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0041 0.0133
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.0413 0.1409
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0779 0.2934 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0065 0.0214
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0064 0.0208
Plasmodium vivax glutathione reductase, putative 0.0049 0.0123 0.6683
Schistosoma mansoni hypothetical protein 0.0035 0.007 0.0239
Treponema pallidum NADH oxidase 0.0017 0.0000081325 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0065 0.0214
Schistosoma mansoni hypothetical protein 0.0314 0.1143 0.3895
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0192 0.0715
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0065 0.0214
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0145 0.0494 0.0494
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0000081325 0.0002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0079 0.071
Schistosoma mansoni cpg binding protein 0.006 0.0165 0.0561
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0779 0.2934 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0000081325 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.0078 0.0235 0.0418
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0065 0.0222
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0365 0.1361
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0065 0.0185 1
Trichomonas vaginalis glucosylceramidase, putative 0.056 0.2089 0.6848
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.0521 0.0521
Trichomonas vaginalis glucosylceramidase, putative 0.0531 0.1979 0.6488
Brugia malayi Cytochrome P450 family protein 0.0028 0.0041 0.0133
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0065 0.0116
Brugia malayi Thioredoxin reductase 0.0049 0.0123 0.0405
Trichomonas vaginalis glucosylceramidase, putative 0.056 0.2089 0.6848
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0065 0.0214
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0192 0.0192
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0065 0.0185 0.0629
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0065 0.0214
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0014 0.0025
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0065 0.0222
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0095 0.0311
Mycobacterium ulcerans hypothetical protein 0.0161 0.0554 0.1889
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0365 0.1245
Brugia malayi MH2 domain containing protein 0.0491 0.1826 0.5985
Echinococcus multilocularis neuropeptide receptor A26 0.1478 0.5625 0.5625
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.0491 0.0873
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0123 0.0405
Brugia malayi MH1 domain containing protein 0.0019 0.0006 0.0019
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.1584 0.1584
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0114 0.2827
Brugia malayi Cytochrome P450 family protein 0.0028 0.0041 0.0133
Brugia malayi nuclear receptor RXR 0.0018 0.0004 0.0012
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0133 0.12
Onchocerca volvulus 0.0082 0.0251 0.097
Schistosoma mansoni lamin 0.0082 0.0251 0.0855
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0106 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.0491 0.1674
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.0413 0.154
Schistosoma mansoni hypothetical protein 0.0145 0.0494 0.1683
Schistosoma mansoni hypothetical protein 0.0145 0.0494 0.1683
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.081 0.3051 1
Brugia malayi nuclear hormone receptor 0.0034 0.0065 0.0214
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.0413 0.154
Leishmania major hypothetical protein, conserved 0.0065 0.0185 0.1662
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0036 0.0063
Loa Loa (eye worm) hypothetical protein 0.0034 0.0065 0.0214
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0000081325 0.0001
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.009 0.4889
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0014 0.0014
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0194 0.0194
Echinococcus granulosus geminin 0.0501 0.1864 0.3314
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0306 0.1111 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0365 0.1361
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0459 0.1702 0.5579
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0000081325 0.0000081325
Loa Loa (eye worm) hypothetical protein 0.0052 0.0133 0.0437
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0065 0.0222
Onchocerca volvulus 0.0052 0.0134 0.036
Loa Loa (eye worm) hypothetical protein 0.0072 0.021 0.0689
Leishmania major hypothetical protein, conserved 0.0065 0.0185 0.1662
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0192 0.0654
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0235 0.08
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0001 0.0004

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Binding affinity to human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) at 200 uM after 2 to 30 mins by absorption spectra analysis ChEMBL. 23391306
AUC (ADMET) = 371 ng.ml/hr AUC (0 to last) in Swiss mouse brain at 10 mg/kg, po ChEMBL. 21880399
CL (ADMET) = 15 ml/min.kg Plasma clearance in Swiss mouse plasma at 1 mg/kg, iv ChEMBL. 21880399
Cmax (ADMET) = 487 ng/ml Cmax in Swiss mouse brain at 10 mg/kg, po ChEMBL. 21880399
F (ADMET) = 42 % Oral bioavailability (0 to last) in Swiss mouse plasma at 10 mg/kg ChEMBL. 21880399
IC50 (binding) > 5 Inhibition of bovine recombinant DASPO expressed in Escherichia coli preincubated for 15 mins by fluorescence assay ChEMBL. 21880399
IC50 (binding) > 5 Inhibition of human ERG expressed in HEK293 cells by whole cell voltage patch clamp technique ChEMBL. 21880399
IC50 (binding) = 9 nM Inhibition of human recombinant DAAO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay ChEMBL. 19438227
IC50 (binding) = 17.2 nM Inhibition of human recombinant DAAO expressed in Escherichia coli assessed as H2O2 production from D-serine degradation after 30 mins by fluorescence assay ChEMBL. 21880399
IC50 (binding) = 141 nM Inhibition of human DAO ChEMBL. 18455394
IC50 (binding) = 424 nM Inhibition of rat recombinant DAAO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay ChEMBL. 19438227
IC50 (binding) > 5000 nM Inhibition of human DDO ChEMBL. 18455394
IC50 (binding) > 19500 nM Inhibition of human recombinant DDO expressed in sf9 insect cells assessed as degradation of D-serine by fluorescence assay ChEMBL. 19438227
IC50 (binding) = 0.177 uM Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by colorimetric assay ChEMBL. 23391306
IC50 (binding) = 0.214 uM Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-alanine as substrate by colorimetric assay ChEMBL. 23391306
IC50 (ADMET) > 10 uM Inhibition of CYP3A4 ChEMBL. 18455394
IC50 (ADMET) > 10 uM Inhibition of CYP2D6 ChEMBL. 18455394
IC50 (binding) > 100 uM Inhibition of human recombinant N-terminal His-tagged serine racemase expressed in Escherichia coli BL21(DE3) using L-serine as substrate after 10 mins by fluorescence assay ChEMBL. 23391306
IC50 (binding) > 100 uM Inhibition of human recombinant N-terminal His-tagged DDO expressed in Escherichia coli BL21(DE3) using D-aspartate as substrate by colorimetric assay ChEMBL. 23391306
Inhibition (binding) Competitive inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-alanine as substrate by Lineweaver-Burk plot analysis ChEMBL. 23391306
Inhibition (binding) Inhibition of N-terminal HA-tagged human recombinant DAO overexpressed in HEK293 cells assessed as increase in D-alanine levels at 17 uM incubated for 30 mins prior to D-alanine addition measured after 24 hrs by HPLC analysis relative to vehicle-treated control ChEMBL. 23391306
Inhibition (binding) Inhibition of human recombinant DAO expressed in G418-resistant HEK293/NEO cells assessed as effect on D-alanine level at 17 uM incubated for 30 mins prior to D-alanine addition measured after 24 hrs by HPLC analysis relative to vehicle-treated control ChEMBL. 23391306
Inhibition (binding) Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by colorimetric assay ChEMBL. 23391306
Kd (binding) = 3.1 nM Binding affinity to human recombinant DAAO by kinetic study scintillation proximity assay ChEMBL. 21880399
Kd (binding) = 14 nM Binding affinity to human recombinant DAAO by isothermal titration calorimeter analysis ChEMBL. 21880399
Kd (binding) = 29 nM Binding affinity to biotinylated human recombinant DAAO by Biacore assay ChEMBL. 19438227
Kd (binding) = 37 nM Binding affinity to human recombinant DAAO by steady state study scintillation proximity assay ChEMBL. 21880399
Ki (binding) = 0.0355 uM Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by Lineweaver-Burk plot analysis ChEMBL. 23391306
T1/2 (ADMET) = 0.5 hr Terminal half life in Swiss mouse brain at 10 mg/kg, po ChEMBL. 21880399
T1/2 (binding) = 10 min Binding affinity to human recombinant DAAO assessed as drug-enzyme complex half life ChEMBL. 21880399
Tmax (ADMET) = 0.25 hr Tmax in Swiss mouse brain at 10 mg/kg, po ChEMBL. 21880399
Vd (ADMET) = 0.8 L/Kg Volume of distribution in Swiss mouse plasma at 1 mg/kg, iv ChEMBL. 21880399

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

4 literature references were collected for this gene.

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