Detailed information for compound 998074

Basic information

Technical information
  • TDR Targets ID: 998074
  • Name: 2-amino-N-[2-[[4-[(4-methylsulfanylphenyl)met hylamino]piperidin-3-yl]amino]-2-oxoethyl]-5- (trifluoromethyl)benzamide
  • MW: 495.561 | Formula: C23H28F3N5O2S
  • H donors: 5 H acceptors: 2 LogP: 2.71 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)CNC1CCNCC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F
  • InChi: 1S/C23H28F3N5O2S/c1-34-16-5-2-14(3-6-16)11-29-19-8-9-28-12-20(19)31-21(32)13-30-22(33)17-10-15(23(24,25)26)4-7-18(17)27/h2-7,10,19-20,28-29H,8-9,11-13,27H2,1H3,(H,30,33)(H,31,32)
  • InChiKey: RZNILJFESMQPTO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-N-[2-[[4-[(4-methylsulfanylphenyl)methylamino]-3-piperidyl]amino]-2-oxo-ethyl]-5-(trifluoromethyl)benzamide
  • 2-amino-N-[2-[[4-[[4-(methylthio)phenyl]methylamino]-3-piperidinyl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
  • 2-amino-N-[2-keto-2-[[4-[[4-(methylthio)benzyl]amino]-3-piperidyl]amino]ethyl]-5-(trifluoromethyl)benzamide
  • 2-amino-N-[2-[[4-[(4-methylsulfanylphenyl)methylamino]piperidin-3-yl]amino]-2-oxo-ethyl]-5-(trifluoromethyl)benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0074 0.0136
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0078 0.0206 0.1018
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0092 0.066
Schistosoma mansoni hypothetical protein 0.0163 0.0469 0.2312
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0003 0.0011
Brugia malayi hypothetical protein 0.0012 0.0003 0.0011
Brugia malayi TAR-binding protein 0.0189 0.055 0.1891
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0403 0.1213 0.417
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0049 0.035
Schistosoma mansoni lipoxygenase 0.0083 0.0223 0.1101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.2714
Plasmodium vivax ataxin-2 like protein, putative 0.0099 0.0273 0.1818
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0125 0.09
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0163 0.0469 0.1611
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0003 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0157 0.1021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0003 0.0016
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0193 0.0564 0.407
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0016
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0081 0.0579
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0082 0.0406
Echinococcus multilocularis tumor protein p63 0.0667 0.2027 0.2027
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0148 0.0729
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.055 0.1891
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0495 0.1497 1
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0003 0.0016
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0125 0.043
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0193 0.0564 0.407
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0003 0.0016
Onchocerca volvulus 0.0012 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0163 0.0469 0.1611
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0013 0.0013
Brugia malayi G protein-coupled receptor 0.0012 0.0003 0.0011
Leishmania major cathepsin L-like protease 0.0016 0.0016 0.005
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0107 0.0366
Echinococcus multilocularis zinc finger protein 0.0043 0.0099 0.0099
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0 0.0002
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.0481 0.1653
Onchocerca volvulus 0.0016 0.0016 0.0118
Schistosoma mansoni polycystin 1-related 0.002 0.0028 0.0137
Schistosoma mansoni hypothetical protein 0.018 0.0524 0.2582
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.0027 0.0027
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0157 0.1044
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0016 0.0107
Brugia malayi MH1 domain containing protein 0.0013 0.0008 0.0027
Brugia malayi RNA binding protein 0.0189 0.055 0.1891
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0222 0.0763
Brugia malayi neuropeptide F receptor 0.0012 0.0003 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0003 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0125 0.09
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0001 0.0003
Echinococcus multilocularis lamin 0.0083 0.0222 0.0222
Brugia malayi hypothetical protein 0.0012 0.0003 0.0011
Onchocerca volvulus 0.0083 0.0222 0.1603
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Onchocerca volvulus 0.0096 0.0264 0.1906
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Onchocerca volvulus 0.0069 0.0179 0.1294
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0069 0.0179 0.0884
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0016 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0001
Schistosoma mansoni chromobox protein 0.0011 0 0.0002
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0003 0.0011
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.0027 0.0134
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0003 0.0011
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0003 0.0016
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0016
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0027 0.0178
Echinococcus multilocularis cysteine protease 0.0016 0.0016 0.0016
Brugia malayi Dopamine receptor protein 1 0.0012 0.0003 0.0011
Echinococcus granulosus Chromo domain 0.0011 0 0.0002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0514 0.1554 0.5342
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0016 0.0081
Plasmodium falciparum ataxin-2 like protein, putative 0.0099 0.0273 0.1818
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0001
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0112
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0039 0.0258
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0074 0.0255
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.0027 0.0027
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0003 0.0016
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0195 0.0195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Mycobacterium ulcerans beta-lactamase 0.0035 0.0074 0.0129
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0003 0.0011
Onchocerca volvulus 0.0012 0.0003 0.0023
Onchocerca volvulus 0.0016 0.0016 0.0118
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0037 0.0191
Leishmania major phosphatidylinositol 3-related kinase, putative 0.002 0.0027 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0157 0.1021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0049 0.035
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0193 0.0564 0.0564
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1391 0.4267 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.0027 0.0151
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0103 0.0355
Echinococcus granulosus orexin receptor type 2 0.0012 0.0003 0.0016
Onchocerca volvulus 0.0012 0.0003 0.0023
Onchocerca volvulus 0.0096 0.0263 0.1895
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.002 0.0027 0.0122
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0534
Brugia malayi RNA, U transporter 1 0.0083 0.0222 0.0763
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0003 0.0003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0027 0.0093
Trypanosoma brucei ISWI complex protein 0.0034 0.007 0.0441
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0016 0.0115
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0016
Mycobacterium tuberculosis Conserved protein 0.0035 0.0074 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Schistosoma mansoni smad1 5 8 and 0.0024 0.0042 0.0205
Brugia malayi Bromodomain containing protein 0.0084 0.0227 0.0779
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.0027 0.0178
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus multilocularis geminin 0.0348 0.1043 0.1043
Trypanosoma cruzi PAB1-binding protein , putative 0.0099 0.0273 0.1817
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0003 0.0016
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.0926 0.3181
Brugia malayi MH1 domain containing protein 0.0013 0.0008 0.0027
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Echinococcus granulosus serine protein kinase ATM 0.0027 0.005 0.0245
Schistosoma mansoni dihydroorotate dehydrogenase 0.0495 0.1497 0.7385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Onchocerca volvulus 0.003 0.0058 0.0417
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0016
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0003 0.0011
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0481 0.0481
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0083 0.0596
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0317 0.0945 0.3249
Leishmania major cathepsin L-like protease 0.0016 0.0016 0.005
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0025 0.0166
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0056 0.0056
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0003 0.0011
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0009 0.0061
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0 0.0002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0163 0.0469 0.0469
Brugia malayi follicle stimulating hormone receptor 0.0952 0.291 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0128
Brugia malayi Valyl-tRNA synthetase 0.0011 0 0.0001
Loa Loa (eye worm) inositol-1 0.0076 0.0201 0.0692
Mycobacterium ulcerans transcriptional regulator 0.1391 0.4267 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0003 0.0016
Schistosoma mansoni smad1 5 8 and 0.0024 0.0042 0.0205
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0025 0.0179
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0081 0.0579
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0003 0.0011
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0082 0.0406
Echinococcus multilocularis fetal alzheimer antigen, falz 0.005 0.012 0.012
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0027 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.005 0.0356
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0016
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Onchocerca volvulus 0.0317 0.0945 0.6822
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0112
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0081 0.0579
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0074 0.0367
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0185 0.0537 0.1845
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0125 0.0617
Entamoeba histolytica hypothetical protein 0.018 0.0524 0.928
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0495 0.1497 0.3484
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0003 0.0003
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0139 0.0684
Schistosoma mansoni smad1 5 8 and 0.0024 0.0042 0.0205
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0656 0.1505
Schistosoma mansoni lamin 0.0083 0.0222 0.1095
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0495 0.1497 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Loa Loa (eye worm) doublecortin family protein 0.002 0.0028 0.0096
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0495 0.1497 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0193 0.0564 0.2783
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0009 0.0061
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.014 0.0934
Leishmania major cathepsin L-like protease 0.0016 0.0016 0.005
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0125 0.0808
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0003 0.0016
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0003 0.0016
Entamoeba histolytica Ran family GTPase 0.0021 0.0032 0.0569
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0074 0.0136
Loa Loa (eye worm) hypothetical protein 0.0099 0.0273 0.0937
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0067
Leishmania major cathepsin L-like protease 0.0016 0.0016 0.005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0027 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0115
Loa Loa (eye worm) hypothetical protein 0.0013 0.0008 0.0027
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.0027 0.0134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0016
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0032 0.0214
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.0027 0.0151
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0201 0.1318
Onchocerca volvulus 0.0016 0.0016 0.0118
Loa Loa (eye worm) hypothetical protein 0.0514 0.1554 0.5342
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0037 0.0042
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0206 0.1018
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0292
Schistosoma mansoni amine GPCR 0.0012 0.0003 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0009 0.0061
Trypanosoma cruzi PAB1-binding protein , putative 0.0099 0.0273 0.1817
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0025 0.0125
Echinococcus multilocularis inositol monophosphatase 1 0.0076 0.0201 0.0201
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0003 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.2714
Loa Loa (eye worm) hypothetical protein 0.003 0.0058 0.0199
Loa Loa (eye worm) Smad1 0.0024 0.0042 0.0143
Onchocerca volvulus 0.0012 0.0003 0.0023
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0201 0.1292
Onchocerca volvulus 0.0011 0 0.0003
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0074 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0261 0.1288
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0495 0.1497 0.5146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0157 0.1021
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0074 0.0493
Brugia malayi hypothetical protein 0.0012 0.0003 0.0011
Schistosoma mansoni hypothetical protein 0.0351 0.1052 0.5188
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0003 0.0016
Schistosoma mansoni opsin-like receptor 0.0012 0.0003 0.0016
Brugia malayi hypothetical protein 0.0012 0.0003 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0016 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Entamoeba histolytica hypothetical protein 0.0027 0.005 0.0875
Onchocerca volvulus 0.0016 0.0016 0.0118
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0037 0.0191
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0115
Onchocerca volvulus 0.0012 0.0003 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0115
Schistosoma mansoni zinc finger protein 0.0034 0.007 0.0347
Onchocerca volvulus 0.0012 0.0003 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0001
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0003 0.0016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0003 0.0016
Brugia malayi Calcitonin receptor-like protein seb-1 0.0514 0.1554 0.5342
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0195 0.0671
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0201 0.145
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0222 0.0763
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0081 0.0579
Brugia malayi Doublecortin family protein 0.002 0.0028 0.0096
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0125 0.0617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0056 0.0346
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0148 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0157 0.1021
Mycobacterium ulcerans TetR family transcriptional regulator 0.1391 0.4267 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0016 0.0081
Brugia malayi latrophilin 2 splice variant baaae 0.0351 0.1052 0.3615
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0074 0.0468
Plasmodium vivax importin-beta 2, putative 0.0029 0.0056 0.0373
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0128
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0193 0.0564 0.407
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0067
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0003 0.0016
Brugia malayi hypothetical protein 0.018 0.0524 0.1799
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Schistosoma mansoni hypothetical protein 0.0163 0.0469 0.2312
Onchocerca volvulus 0.0012 0.0003 0.0023
Mycobacterium tuberculosis Conserved protein 0.0035 0.0074 0.0136
Schistosoma mansoni alpha glucosidase 0.0037 0.0081 0.0397
Loa Loa (eye worm) nuclear factor I 0.0013 0.0008 0.0027
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0092 0.0663
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0125 0.0832
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0025 0.0087
Loa Loa (eye worm) hypothetical protein 0.0023 0.0037 0.0128
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0157 0.1044
Echinococcus multilocularis somatostatin receptor 0.0012 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.018 0.0524 0.928
Echinococcus granulosus neuropeptide receptor A26 0.0511 0.1548 0.7633
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0003 0.0016
Brugia malayi MH2 domain containing protein 0.0357 0.1071 0.368
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0157 0.1021
Brugia malayi SET domain containing protein 0.0013 0.0007 0.0024
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0042 0.0205
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0514 0.1554 0.5342
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.002 0.0027 0.0122
Brugia malayi Dopamine receptor 0.0012 0.0003 0.0011
Trichomonas vaginalis esterase, putative 0.0035 0.0074 0.0534
Echinococcus granulosus sex peptide receptor 0.0012 0.0003 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0074 0.0494
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0003 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0074 0.0534
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0009 0.0061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0148 0.0302
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0145 0.0145
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0081 0.0535
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0081 0.0579
Brugia malayi Serotonin receptor 0.0012 0.0003 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0016 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.002 0.0027 0.0473
Brugia malayi hypothetical protein 0.002 0.0028 0.0096
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Onchocerca volvulus 0.0011 0 0.0003
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0003 0.0011
Brugia malayi hypothetical protein 0.0012 0.0003 0.0011
Leishmania major phosphatidylinositol 3-kinase, putative 0.002 0.0027 0.0122
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0003 0.0016
Trypanosoma brucei protein kinase, putative 0.0051 0.0125 0.0808
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0003 0.0016
Schistosoma mansoni hypothetical protein 0.0011 0 0.0002
Brugia malayi hypothetical protein 0.002 0.0028 0.0096
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0076 0.0201 0.145
Trypanosoma cruzi target of rapamycin kinase 3 0.002 0.0027 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0206 0.1486
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0096
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0003
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0016 0.0118
Brugia malayi beta-lactamase family protein 0.0035 0.0074 0.0255
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0016 0.005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0074 0.0534
Onchocerca volvulus 0.0012 0.0003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0255
Brugia malayi Fli-1 protein 0.0225 0.0661 0.2271
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0025 0.0165
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.002 0.0027 0.0177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0016
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0003 0.0016
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0025 0.011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0163 0.0469 0.2312
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.018 0.0524 0.0524
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.055 0.1891
Schistosoma mansoni myosin xvIII 0.0012 0.0003 0.0016
Echinococcus granulosus tar DNA binding protein 0.0189 0.055 0.2714
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0086 0.0297
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0364 0.1092 0.3751
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0495 0.1497 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0056 0.0193
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0037 0.0042
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0016 0.0107
Schistosoma mansoni inositol monophosphatase 0.0076 0.0201 0.0992
Mycobacterium ulcerans hypothetical protein 0.0023 0.0037 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Onchocerca volvulus 0.0012 0.0003 0.0023
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.0481 0.1653
Plasmodium vivax SET domain protein, putative 0.0058 0.0145 0.0967
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0157 0.1021
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0037 0.0042
Leishmania major dihydroorotate dehydrogenase 0.0495 0.1497 1
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0028 0.0028
Schistosoma mansoni chromobox protein 0.0011 0 0.0002
Toxoplasma gondii ABC1 family protein 0.0035 0.0074 0.0494
Schistosoma mansoni gabp alpha 0.0074 0.0195 0.0962
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0003 0.0011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0074 0.0367
Echinococcus granulosus chromobox protein 2 0.0011 0 0.0002
Brugia malayi hypothetical protein 0.0099 0.0273 0.0937
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0103 0.0355
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0003 0.0003
Schistosoma mansoni biogenic amine receptor 0.0012 0.0003 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1391 0.4267 1
Brugia malayi Dopamine receptor protein 2 0.0012 0.0003 0.0011
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0 0.0002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0074 0.0255
Onchocerca volvulus 0.0083 0.0222 0.1603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Leishmania major hypothetical protein, conserved 0.0034 0.007 0.0413
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0003 0.0016
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0193 0.0564 0.407
Loa Loa (eye worm) hypothetical protein 0.0023 0.0038 0.0131
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0003 0.0016
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0074 0.0136
Loa Loa (eye worm) MH2 domain-containing protein 0.0357 0.1071 0.368
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0003 0.0016
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0076 0.0201 0.3562
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0012 0.0003 0.0016
Onchocerca volvulus Neuropeptide F receptor homolog 0.0012 0.0003 0.0023
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.2027 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0031
Echinococcus granulosus RUN 0.002 0.0028 0.0137
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0157 0.1044
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0044 0.0104 0.0512
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0003 0.0016
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0495 0.1497 1
Plasmodium vivax vivapain-2 0.0016 0.0016 0.0107
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0056
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0028 0.0183
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0163 0.0469 0.0469
Loa Loa (eye worm) cysteine protease 0.0016 0.0016 0.0056
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus granulosus smad 0.0024 0.0042 0.0205
Echinococcus granulosus neuropeptide receptor 0.0012 0.0003 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Schistosoma mansoni inositol monophosphatase 0.0076 0.0201 0.0992
Echinococcus granulosus chromobox protein 1 0.0067 0.0174 0.086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0148 0.0302
Brugia malayi hypothetical protein 0.0012 0.0003 0.0011
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0078 0.0206 0.0709
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0214
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0003 0.0003
Onchocerca volvulus 0.0459 0.1386 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0193 0.0564 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0016
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.005 0.012 0.059
Loa Loa (eye worm) hypothetical protein 0.0098 0.0268 0.0921
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0003 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0157 0.1021
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0201 0.134
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0016 0.0016
Echinococcus multilocularis snurportin 1 0.031 0.0926 0.0926
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0016
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0003 0.0011
Echinococcus granulosus chromobox protein 1 0.0067 0.0174 0.086
Loa Loa (eye worm) hypothetical protein 0.009 0.0243 0.0836
Echinococcus multilocularis Smad4 0.0024 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0082 0.0082
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.002 0.0027 0.0177
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0222 0.0763
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0003 0.0011
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.0481 0.2373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0163 0.0469 0.2312
Echinococcus multilocularis musashi 0.0083 0.0222 0.0222
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0125 0.0781
Leishmania major GTP-binding protein, putative 0.0021 0.0032 0.0159
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0016
Trichomonas vaginalis set domain proteins, putative 0.0459 0.1386 1
Brugia malayi MAP kinase sur-1 0.0051 0.0125 0.043
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0076 0.0201 0.1195
Brugia malayi Heterochromatin protein 1 0.0067 0.0174 0.06
Schistosoma mansoni bromodomain containing protein 0.0139 0.0396 0.1955
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0074 0.0367
Entamoeba histolytica hypothetical protein 0.018 0.0524 0.928
Loa Loa (eye worm) hypothetical protein 0.047 0.1418 0.4874
Loa Loa (eye worm) hypothetical protein 0.0038 0.0085 0.0292
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus granulosus Smad4 0.0024 0.0042 0.0205
Echinococcus granulosus tumor protein p63 0.0667 0.2027 0.9998
Echinococcus granulosus neuropeptide s receptor 0.0511 0.1548 0.7633
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0003 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.2714
Onchocerca volvulus 0.0012 0.0003 0.0023
Echinococcus multilocularis tar DNA binding protein 0.0189 0.055 0.055
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0016 0.0283
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0003 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0027 0.0093
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0193 0.0564 0.407
Brugia malayi intermediate filament protein 0.0083 0.0222 0.0763
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0255
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0074 0.0074
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0009 0.015
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0125 0.0832
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0003 0.0016
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0068 0.0177 0.0377
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0125 0.0833
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.2714
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0037 0.0655
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0125 0.09
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Brugia malayi hypothetical protein 0.0064 0.0164 0.0564
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0351 0.1052 0.3615
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0042 0.0143
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0092 0.066
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0115
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0193 0.0564 0.407
Schistosoma mansoni hypothetical protein 0.0348 0.1043 0.5144
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0495 0.1497 0.3479
Mycobacterium ulcerans lipase LipD 0.0035 0.0074 0.0129
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0163 0.0469 0.2312
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0005 0.0027
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0016 0.0081
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0148 0.0302
Brugia malayi hypothetical protein 0.0011 0 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0037 0.0128
Schistosoma mansoni neuropeptide receptor 0.0012 0.0003 0.0016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0163 0.0469 0.1611
Brugia malayi Ets-domain containing protein 0.0074 0.0195 0.0671
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0 0.0001
Brugia malayi Bromodomain containing protein 0.0165 0.0476 0.1636
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Echinococcus granulosus survival motor neuron protein 1 0.047 0.1418 0.6996
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.0537 0.0537
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0003 0.0003
Plasmodium falciparum importin beta, putative 0.0029 0.0056 0.0373
Leishmania major cathepsin L-like protease 0.0062 0.0157 0.0994
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0079 0.0211 0.0211
Echinococcus multilocularis serotonin receptor 0.0012 0.0003 0.0003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0039 0.028
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.005 0.0171
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.009 0.009
Brugia malayi Melatonin receptor type 1A 0.0012 0.0003 0.0011
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0206 0.1018
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0174 0.1256
Echinococcus granulosus histone lysine methyltransferase setb 0.0095 0.0261 0.1288
Mycobacterium ulcerans hypothetical protein 0.0035 0.0074 0.0129
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0037 0.0128
Brugia malayi MH2 domain containing protein 0.0024 0.0042 0.0143
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0081 0.0397
Loa Loa (eye worm) hypothetical protein 0.0063 0.0162 0.0557
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.005 0.0303
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0028 0.0028
Echinococcus granulosus g protein coupled receptor 0.0012 0.0003 0.0016
Echinococcus granulosus g protein coupled receptor 0.0012 0.0003 0.0016
Trichomonas vaginalis ran, putative 0.0021 0.0032 0.0232
Brugia malayi GnHR receptor homolog 0.0012 0.0003 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0003 0.0003
Loa Loa (eye worm) ctsf protein 0.0016 0.0016 0.0056
Echinococcus granulosus allatostatin A receptor 0.0012 0.0003 0.0016
Leishmania major hypothetical protein, conserved 0.0035 0.0074 0.044
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0003 0.0003
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0003 0.0003
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0125 0.0617
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0056 0.0373
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0206 0.0206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0003
Brugia malayi chromobox protein homolog 3 0.0038 0.0083 0.0285
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0003 0.0003
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0174 0.1256
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0125 0.0125
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0027 0.0093
Echinococcus granulosus cathepsin l1 0.0016 0.0016 0.0081
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0003 0.0003
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0495 0.1497 0.3451
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Schistosoma mansoni importin beta-1 0.0029 0.0056 0.0277
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0095 0.0261 0.0261
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0095 0.0261 0.0897
Brugia malayi larval opioid receptor 0.0012 0.0003 0.0011
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0013 0.0066
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0038 0.025
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0206 0.1374
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0157 0.1044
Mycobacterium tuberculosis Conserved protein 0.0035 0.0074 0.0136
Brugia malayi Latrophilin receptor protein 2 0.0163 0.0469 0.1611
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0081 0.0277
Echinococcus granulosus intermediate filament protein 0.0083 0.0222 0.1095
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0096
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0081 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Echinococcus granulosus neuropeptide receptor 0.0012 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus granulosus ubiquitin specific protease 41 0.0078 0.0206 0.1018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.0537 0.2648
Brugia malayi RE15519p 0.0012 0.0003 0.0011
Trypanosoma brucei glucosidase, putative 0.0037 0.0081 0.0509
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0193
Onchocerca volvulus 0.0016 0.0016 0.0118
Echinococcus granulosus GPCR family 2 0.0163 0.0469 0.2312
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Schistosoma mansoni opsin-like receptor 0.0012 0.0003 0.0016
Brugia malayi Protein cec-1. 0.0011 0 0.0001
Trypanosoma cruzi ISWI complex protein 0.0034 0.007 0.0466
Brugia malayi Smad1 0.0024 0.0042 0.0143
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0263 0.0902
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0125 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Onchocerca volvulus 0.002 0.0028 0.0201
Loa Loa (eye worm) hypothetical protein 0.0084 0.0227 0.0781
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0019 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0001
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0495 0.1497 0.5146
Onchocerca volvulus 0.0016 0.0016 0.0118
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0003 0.0003
Schistosoma mansoni amine GPCR 0.0012 0.0003 0.0016
Schistosoma mansoni histamine h1 receptor 0.0012 0.0003 0.0016
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0056
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0255
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0003 0.0016
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0081 0.0277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0115
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0016 0.0056
Brugia malayi hypothetical protein 0.0012 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0255
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0255
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0044 0.0104 0.0104
Echinococcus granulosus importin subunit beta 1 0.0029 0.0056 0.0277
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Leishmania major cathepsin L-like protease 0.0016 0.0016 0.005
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0009 0.0061
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.0537 0.2648
Echinococcus multilocularis sex peptide receptor 0.0012 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0042 0.0205
Brugia malayi G-protein coupled receptor 0.0012 0.0003 0.0011
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0145 0.0967
Schistosoma mansoni neuropeptide receptor 0.0012 0.0003 0.0016
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0056
Onchocerca volvulus 0.0098 0.0268 0.1934
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0003 0.0003
Schistosoma mansoni rab6-interacting 0.002 0.0028 0.0137
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0074 0.0136
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0025 0.0165
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0009 0.0061
Echinococcus granulosus microtubule associated protein 2 0.0667 0.2027 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0081 0.0534
Schistosoma mansoni alpha-glucosidase 0.0143 0.0409 0.2019
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0081 0.0579
Leishmania major importin beta-1 subunit, putative 0.0024 0.0039 0.0204
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0003 0.0016
Onchocerca volvulus 0.0016 0.0016 0.0118
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0081 0.0579
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0125 0.09
Mycobacterium leprae Probable lipase LipE 0.0035 0.0074 0.0087
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0076 0.0201 0.0428
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0003 0.0003
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0003 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Toxoplasma gondii FATC domain-containing protein 0.0027 0.005 0.033
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.0027 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0157 0.1021
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0082 0.0406
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0003 0.0011
Schistosoma mansoni hypothetical protein 0.0096 0.0263 0.1295
Loa Loa (eye worm) hypothetical protein 0.0083 0.0222 0.0763
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0534
Schistosoma mansoni hypothetical protein 0.0045 0.0107 0.0526
Plasmodium vivax vivapain-2 0.0016 0.0016 0.0107
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0016
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0001 0.0003
Echinococcus multilocularis survival motor neuron protein 1 0.047 0.1418 0.1418
Schistosoma mansoni neuropeptide receptor 0.0012 0.0003 0.0016
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0081 0.1422
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0025 0.5
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0013 0.0046
Echinococcus granulosus fetal alzheimer antigen falz 0.005 0.012 0.059
Giardia lamblia GTOR 0.002 0.0027 0.01
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0157 0.1021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Onchocerca volvulus 0.002 0.0028 0.0201
Onchocerca volvulus 0.0012 0.0003 0.0023
Onchocerca volvulus 0.0012 0.0003 0.0023
Echinococcus multilocularis neuropeptide s receptor 0.0511 0.1548 0.1548
Entamoeba histolytica hypothetical protein 0.018 0.0524 0.928
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0003 0.0003
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0206 0.0206
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0025 0.0014
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0003 0.0016
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0027 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.0334 0.0334
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0003 0.0016
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0125
Echinococcus granulosus somatostatin receptor 0.0012 0.0003 0.0016
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0042 0.0143
Echinococcus multilocularis ubiquitin specific protease 41 0.0078 0.0206 0.0206
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0148 0.0729
Echinococcus multilocularis chromobox protein 1 0.0067 0.0174 0.0174
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0003 0.0016
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0009 0.0031
Brugia malayi hypothetical protein 0.0012 0.0003 0.0011
Schistosoma mansoni amine GPCR 0.0012 0.0003 0.0016
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0495 0.1497 1
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0003 0.0016
Schistosoma mansoni smad 0.0024 0.0042 0.0205
Loa Loa (eye worm) fli-1 protein 0.0225 0.0661 0.2271
Brugia malayi MH2 domain containing protein 0.0024 0.0042 0.0143
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.0334 0.1647
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0003 0.0003
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0009 0.0029
Toxoplasma gondii cathepsin CPL 0.0016 0.0016 0.0107
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0193 0.0564 0.0564
Echinococcus granulosus hypothetical protein 0.0012 0.0003 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0157 0.1021
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0213
Schistosoma mansoni survival motor neuron protein 0.0096 0.0263 0.1295
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0003 0.0016
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0056
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0148 0.0984
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0076 0.0201 0.1341
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0193 0.0564 0.3765
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0074 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0009 0.0055
Leishmania major cathepsin L-like protease 0.0062 0.0157 0.0994
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0003 0.0003
Onchocerca volvulus 0.0012 0.0003 0.0023
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0016
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0025 0.0021
Toxoplasma gondii LsmAD domain-containing protein 0.0099 0.0273 0.1818
Brugia malayi MH1 domain containing protein 0.0024 0.0042 0.0143
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0003 0.0016
Leishmania major hypothetical protein, conserved 0.0099 0.0273 0.1772
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0003 0.0003
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0028 0.0183
Loa Loa (eye worm) hypothetical protein 0.0364 0.1092 0.3751
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0042 0.0205
Schistosoma mansoni hypothetical protein 0.0044 0.0104 0.0512
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0003
Echinococcus granulosus geminin 0.0348 0.1043 0.5144
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0268 0.1322
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0148 0.0309
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0016
Echinococcus multilocularis serotonin receptor 0.0012 0.0003 0.0003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0074 0.0129
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0024 0.0039 0.0688
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0016
Schistosoma mansoni hypothetical protein 0.0034 0.007 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0005 0.003
Schistosoma mansoni hypothetical protein 0.002 0.0028 0.0137
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.002 0.0027 0.0473
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0195 0.0962
Loa Loa (eye worm) RNA binding protein 0.0189 0.055 0.1891
Onchocerca volvulus 0.0012 0.0003 0.0023
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0028 0.0137
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.009 0.0443
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0952 0.291 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0115
Onchocerca volvulus 0.0012 0.0003 0.0023
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0081 0.0579
Brugia malayi CHD4 protein 0.0015 0.0013 0.0046
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0019 0.0007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0025 0.0025
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0125 0.0781
Schistosoma mansoni lamin 0.0083 0.0222 0.1095
Loa Loa (eye worm) helicase 0.0011 0 0.0001
Schistosoma mansoni rab6-interacting 0.002 0.0028 0.0137
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0193 0.0564 0.2783
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0125 0.0832
Schistosoma mansoni ran 0.0021 0.0032 0.016
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0003 0.0016
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0019 0.5
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0078 0.0206 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0206 0.1352
Onchocerca volvulus 0.0012 0.0003 0.0023
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.002 0.0027 0.0177
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.005 0.0245
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0016 0.0118
Schistosoma mansoni alpha-glucosidase 0.0143 0.0409 0.2019
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0001 0.0002
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0016 0.0056
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0056
Onchocerca volvulus 0.0023 0.0037 0.0269
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0003 0.0016
Echinococcus granulosus snurportin 1 0.031 0.0926 0.4565
Loa Loa (eye worm) hypothetical protein 0.0094 0.0256 0.0881
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0009 0.0055
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0078 0.0206 0.1326
Schistosoma mansoni hypothetical protein 0.0348 0.1043 0.5144
Brugia malayi hypothetical protein 0.0317 0.0945 0.3249
Loa Loa (eye worm) fibroinase 0.0016 0.0016 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0003 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0074 0.0493
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0013 0.0066
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0019 0.0127
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.0481 0.0481
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0009 0.0061
Schistosoma mansoni lipoxygenase 0.0119 0.0334 0.1647
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0067
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0037 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0003 0.0016
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0116 0.0772
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0125 0.0125
Brugia malayi Ets-domain containing protein 0.0074 0.0195 0.0671
Trichomonas vaginalis conserved hypothetical protein 0.0354 0.1061 0.7655
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0003
Brugia malayi hypothetical protein 0.047 0.1418 0.4874
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0145 0.0716
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0148 0.0729
Echinococcus granulosus serotonin receptor 0.0012 0.0003 0.0016
Echinococcus granulosus Chromobox protein 3 0.0011 0 0.0002
Schistosoma mansoni hypothetical protein 0.031 0.0926 0.4565
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0495 0.1497 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0206 0.0709
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1391 0.4267 1
Brugia malayi Pre-SET motif family protein 0.0058 0.0145 0.0499
Brugia malayi hypothetical protein 0.0012 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0001 0.0003
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0032 0.016
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0042 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Schistosoma mansoni adenoreceptor 0.0012 0.0003 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0037 0.0655
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.0027 0.0134
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.0537 0.2648
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.005 0.0328
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0003
Loa Loa (eye worm) TAR-binding protein 0.0189 0.055 0.1891
Onchocerca volvulus 0.0035 0.0074 0.0536
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0025 0.0441
Schistosoma mansoni amine GPCR 0.0012 0.0003 0.0016
Echinococcus granulosus zinc finger protein 0.0043 0.0099 0.049
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0081 0.0579
Trichomonas vaginalis inositol monophosphatase, putative 0.0076 0.0201 0.145
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0016 0.0118
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0206 0.1486
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.0537 0.2648
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0534
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0037 0.0049
Loa Loa (eye worm) hypothetical protein 0.0038 0.0083 0.0285
Onchocerca volvulus 0.0035 0.0074 0.0536
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0039 0.028
Echinococcus multilocularis smad 0.0024 0.0042 0.0042
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0042 0.0042
Schistosoma mansoni biogenic amine receptor 0.0012 0.0003 0.0016
Loa Loa (eye worm) hypothetical protein 0.0011 0 0.0001
Brugia malayi hypothetical protein 0.0012 0.0003 0.0011
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0125
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0032 0.0032
Brugia malayi putative neuropeptide receptor 0.0012 0.0003 0.0011
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0187
Plasmodium falciparum ataxin-2 like protein, putative 0.0099 0.0273 0.1818
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0056 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0083 0.0596
Schistosoma mansoni opsin-like receptor 0.0012 0.0003 0.0016
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.2027 0.2027
Schistosoma mansoni ets-related 0.0225 0.0661 0.326
Brugia malayi AKH receptor 0.0012 0.0003 0.0011
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.0027 0.0151
Loa Loa (eye worm) hypothetical protein 0.0155 0.0447 0.1536
Leishmania major cathepsin L-like protease 0.0062 0.0157 0.0994
Schistosoma mansoni transcription factor LCR-F1 0.018 0.0524 0.2582
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0037 0.0042
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0009 0.0061
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0016 0.0283
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0131 0.0372 0.0372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0157 0.1021
Schistosoma mansoni chromobox protein 0.0067 0.0174 0.086
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0206 0.1486
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0025 0.0087
Echinococcus granulosus inositol monophosphatase 1 0.0076 0.0201 0.0992
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0095 0.0261 0.1288
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0016
Loa Loa (eye worm) transcription factor SMAD2 0.0357 0.1071 0.368
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0074 0.0129
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0206 0.1374
Schistosoma mansoni hypothetical protein 0.0163 0.0469 0.2312
Echinococcus multilocularis GPCR, family 2 0.0163 0.0469 0.0469
Schistosoma mansoni loxhd1 0.002 0.0028 0.0137
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0003 0.0003
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0074 0.0136
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Brugia malayi neuropeptide F receptor 0.0012 0.0003 0.0011
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0016 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0027 0.0192
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0025 0.0166
Brugia malayi Inositol-1 0.0076 0.0201 0.0692
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0081 0.0534
Entamoeba histolytica cysteine protease, putative 0.0016 0.0016 0.0283
Schistosoma mansoni tar DNA-binding protein 0.0189 0.055 0.2714
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0028 0.0137
Brugia malayi Pre-SET motif family protein 0.0403 0.1213 0.417
Echinococcus granulosus g protein coupled receptor 0.0012 0.0003 0.0016
Brugia malayi G-protein coupled receptor 0.0012 0.0003 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0115
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0003 0.0016
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0148 0.0933
Schistosoma mansoni Smad4 0.0024 0.0042 0.0205
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0131 0.0372 0.1835
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0125 0.5517
Brugia malayi Associated with TFs and helicases family protein 0.0011 0 0.0001
Schistosoma mansoni ran 0.0021 0.0032 0.016
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0001 0.0001
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0003 0.0003
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.0027 0.0151
Toxoplasma gondii exonuclease III APE 0.0019 0.0025 0.0166
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0081 0.1422
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0037 0.0042
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0078 0.0206 0.1018
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0056
Schistosoma mansoni zinc finger protein 0.0043 0.0099 0.049
Brugia malayi Cathepsin L-like precursor 0.0016 0.0016 0.0056
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.018 0.0524 0.2582
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Brugia malayi PHD-finger family protein 0.0055 0.0136 0.0466
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0003 0.0016
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0003 0.0016
Trypanosoma brucei PAB1-binding protein , putative 0.0099 0.0273 0.1796
Brugia malayi Zinc finger, C2H2 type family protein 0.0193 0.0564 0.1939
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0037 0.0191
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0174 0.06
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0185 0.0537 0.1845
Brugia malayi sulfakinin receptor protein 0.0012 0.0003 0.0011
Schistosoma mansoni chromobox protein 0.0067 0.0174 0.086
Echinococcus multilocularis chromobox protein 1 0.0067 0.0174 0.0174
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0083 0.0599
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0016 0.0056
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0076 0.0201 0.134
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0025 0.0179
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0079 0.0211 0.1039
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.005 0.005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0074 0.0136
Plasmodium falciparum dihydroorotate dehydrogenase 0.0495 0.1497 1
Schistosoma mansoni intermediate filament proteins 0.0083 0.0222 0.1095
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0003 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0037 0.0128
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.002 0.0027 0.0122
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Echinococcus granulosus lamin 0.0083 0.0222 0.1095
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0028 0.0137
Schistosoma mansoni amine GPCR 0.0012 0.0003 0.0016
Brugia malayi ORL1-like opioid receptor 0.0012 0.0003 0.0011
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0003 0.0003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0037 0.0655
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0037 0.0042
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0068 0.0177 0.0329
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0037 0.0049
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0003 0.0011
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0003 0.0011
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0003 0.0011
Brugia malayi Serotonin receptor 0.0012 0.0003 0.0011
Onchocerca volvulus 0.0035 0.0074 0.0536
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0025 0.0139
Loa Loa (eye worm) hypothetical protein 0.0081 0.0217 0.0747
Echinococcus multilocularis lamin dm0 0.0083 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.004 0.009 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0005 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Echinococcus multilocularis RUN 0.002 0.0028 0.0028
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0012 0.0003 0.0023
Onchocerca volvulus 0.0012 0.0003 0.0023
Brugia malayi beta-lactamase family protein 0.0035 0.0074 0.0255
Brugia malayi beta-lactamase 0.0035 0.0074 0.0255
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0399
Echinococcus multilocularis neuropeptide receptor A26 0.0511 0.1548 0.1548
Echinococcus granulosus fmrfamide receptor 0.0012 0.0003 0.0016
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0039 0.028
Trypanosoma cruzi ISWI complex protein 0.0034 0.007 0.0466
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.0027 0.0134
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0032 0.0214
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0078 0.0206 0.3652
Brugia malayi MH1 domain containing protein 0.0024 0.0042 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.0537 0.2648
Echinococcus granulosus lamin dm0 0.0083 0.0222 0.1095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0016 0.0115
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0003 0.0016
Schistosoma mansoni biogenic amine receptor 0.0012 0.0003 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0003 0.0003
Echinococcus multilocularis cysteine protease 0.0016 0.0016 0.0016
Loa Loa (eye worm) beta-lactamase 0.0035 0.0074 0.0255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0016 0.0115
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0255

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.1 nM Binding affinity to wild type CCR2 ChEMBL. 18722120
IC50 (binding) = 6.3 nM Displacement of radiolabeled MCP1 from CCR2 in human PBMC by millipore filter plate assay ChEMBL. 18722120
IC50 (functional) = 7 nM Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced calcium flux by fluorescence-imaging plate assay ChEMBL. 18722120
IC50 (functional) = 285 nM Antagonist activity at CCR2 in human PBMC assessed as MCP1-induced chemotaxis ChEMBL. 18722120
Inhibition (binding) = 47.3 % Inhibition of CCR3 at 10 uM ChEMBL. 18722120

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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