Detailed view for EmuJ_000280400

Basic information

TDR Targets ID: 962096
Echinococcus multilocularis, pol protein
Source Database / ID:  GeneDB

pI: 8.5368 | Length (AA): 145 | MW (Da): 15908 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00665   Integrase core domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0003676   nucleic acid binding  
GO:0015074   DNA integration  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
29 117 1ex4 (A) 63 162 39.00 0.0073 0.98 0.890393 -0.04
35 117 3kks (A) 74 162 36.00 0.011 1 0.813014 -0.46
44 144 3dlr (A) 147 258 33.00 0.000024 0.96 1.03915 0.08
83 131 3jwd (A) 278 360 37.00 0.97 0.43 0.707531 -0.62

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134588)

Species Accession Gene Product
Echinococcus multilocularis EmuJ_000280400   pol protein
Echinococcus multilocularis EmuJ_000280600   pol protein
Echinococcus multilocularis EmuJ_000274500   pol protein
Echinococcus multilocularis EmuJ_000559900   pol protein
Homo sapiens 100996619   uncharacterized LOC100996619
Trypanosoma congolense TcIL3000_0_47160   Integrase core domain containing protein, putative
Trypanosoma congolense TcIL3000_0_30390   Integrase core domain containing protein, putative
Trypanosoma congolense TcIL3000_0_39680   RNase H/Integrase core domain containing protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Woolly monkey sarcoma virus Simian sarcoma virus Pol protein Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Human immunodeficiency virus 2 Human immunodeficiency virus type 2 integrase 95 aa 26.4% 91 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.299 1 1
0.1235 0.3711 0.7973
0.1718 0.2878 1
0.0775 0.3236 0.3235
0.1794 1 1
0.1208 0.2704 0.2704
0.0455 1 1
0.2389 1 1
0.3001 0.564 1
0.1504 1 1
0.3001 0.564 1
0.1808 0.8504 1
0.0465 0.3708 0.4383
0.2586 0.4607 1
0.2453 0.4531 1
0.2548 1 1
0.1713 1 1
0.0989 0.5073 0.5072
0.1959 0.3118 1
0.1808 0.8504 1
0.1782 1 1
0.1768 1 1
0.1759 1 1
0.3519 0.3711 1
0.1575 0.283 1
0.1788 1 1
0.1323 0.401 1
0.2453 0.4531 1
0.2762 1 1
0.0259 0.452 0.5
0.3001 0.564 1
0.3216 1 1
0.1757 1 1
0.3216 1 1
0.0259 0.3152 0.3152
0.2513 1 1
0.2755 1 1
0.0634 0.2992 0.2992
0.1801 1 1
0.1751 1 1
0.3002 1 1
0.0634 0.2992 0.2992
0.2197 0.3521 1
0.1208 0.2704 0.2704
0.3519 0.3711 1
0.3251 1 1
0.1784 1 1
0.1767 0.5246 0.5246
0.0961 0.2525 0.3415
0.0822 0.37 0.5141
0.0827 0.3698 0.4026
0.3519 0.3711 1
0.0989 0.5073 0.5072
0.278 1 1
0.2429 0.4055 1
0.2623 0.4606 1
0.1208 0.2704 0.2704
0.0822 0.3584 0.3583
0.1938 0.3219 1
0.0259 0.6558 0.5
0.1857 0.3491 1
0.1106 0.3711 0.8735
0.0634 0.2992 0.2992
0.0634 0.2992 0.2992
0.1769 1 1
0.1788 1 1
0.1843 1 1
0.0827 0.3697 0.4162
0.1843 1 1
0.0889 0.3254 0.3252
0.1768 1 1
0.1846 1 1
0.1167 1 0.5
0.3001 0.564 1
0.0259 1 1
0.163 1 1
0.1768 1 1
0.2795 1 1
0.1938 0.3219 1
0.0259 1 1
0.1781 1 1
0.1767 0.5246 0.5246
0.2068 0.3814 1
0.163 1 1
0.0889 0.3254 0.3252
0.2503 1 1
0.2444 0.4535 1
0.1208 0.2704 0.2704
0.3236 1 1
0.0634 0.2992 0.2992
0.1768 1 1
0.1759 1 1
0.2389 1 1
0.1072 0.7117 0.7117
0.2381 0.4309 1
0.2197 0.3521 1
0.0961 0.3696 0.6659
0.0692 0.3234 0.3234
0.1961 0.3199 1
0.1768 1 1
0.3023 0.5612 1
0.1959 0.3118 1
0.0634 0.2992 0.2992
0.0752 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000280400 (Echinococcus multilocularis), pol protein
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