Detailed information for compound 282467

Basic information

Technical information
  • TDR Targets ID: 282467
  • Name: tert-butyl N-[3-[[4-[methyl(4-pyrrolidin-1-yl but-2-ynyl)amino]-4-oxobutyl]amino]-3-oxoprop yl]carbamate
  • MW: 408.535 | Formula: C21H36N4O4
  • H donors: 2 H acceptors: 3 LogP: 0.55 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CCNC(=O)OC(C)(C)C)NCCCC(=O)N(CC#CCN1CCCC1)C
  • InChi: 1S/C21H36N4O4/c1-21(2,3)29-20(28)23-13-11-18(26)22-12-9-10-19(27)24(4)14-5-6-15-25-16-7-8-17-25/h7-17H2,1-4H3,(H,22,26)(H,23,28)
  • InChiKey: CZQGGNAUFBUCRS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • tert-butyl N-[3-[[4-[methyl(4-pyrrolidin-1-ylbut-2-ynyl)amino]-4-oxo-butyl]amino]-3-oxo-propyl]carbamate
  • N-[3-[[4-[methyl-[4-(1-pyrrolidinyl)but-2-ynyl]amino]-4-oxobutyl]amino]-3-oxopropyl]carbamic acid tert-butyl ester
  • N-[3-keto-3-[[4-keto-4-[methyl(4-pyrrolidinobut-2-ynyl)amino]butyl]amino]propyl]carbamic acid tert-butyl ester
  • tert-butyl N-[3-[[4-(methyl-(4-pyrrolidin-1-ylbut-2-ynyl)amino)-4-oxobutyl]amino]-3-oxopropyl]carbamate
  • tert-butyl N-[3-[[4-(methyl-(4-pyrrolidin-1-ylbut-2-ynyl)amino)-4-oxo-butyl]amino]-3-oxo-propyl]carbamate
  • N-[3-[[4-(methyl-(4-1-pyrrolidinylbut-2-ynyl)amino)-4-oxobutyl]amino]-3-oxopropyl]carbamic acid tert-butyl ester
  • N-[3-keto-3-[[4-keto-4-(methyl-(4-pyrrolidin-1-ylbut-2-ynyl)amino)butyl]amino]propyl]carbamic acid tert-butyl ester
  • 4-(Aminopropionamido)butanamide, N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl]-N'-BOC-
  • 4-(N-t-butyloxycarbonylaminopropionamido)butanamide, N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl]

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 0.0019 0.0015 0.0029
Mycobacterium ulcerans beta-lactamase 0.0042 0.0091 0.0272
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Echinococcus multilocularis follistatin 0.0088 0.0246 0.0246
Trypanosoma brucei metacaspase MCA2 0.002 0.002 0.0031
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0015 0.0002 0.0006
Onchocerca volvulus 0.0036 0.0071 0.0213
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0016 0.0004 0.0006
Entamoeba histolytica P-glycoprotein-2 0.0024 0.0033 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0086
Onchocerca volvulus 0.0042 0.0091 0.0273
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0001 0.000000000061058
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0087 0.026
Schistosoma mansoni NADPH flavin oxidoreductase 0.0069 0.0184 0.0352
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0002 0.0003
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0015 0.0002 0.0006
Schistosoma mansoni hypothetical protein 0.0015 0.0002 0.0004
Loa Loa (eye worm) ctsf protein 0.0036 0.0071 0.0213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0013 0.002
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0013 0.0025
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0033 0.0146
Trypanosoma brucei metacaspase 5, putative 0.002 0.002 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0016 0.0049
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.0761 0.2285
Loa Loa (eye worm) DR-78 0.0019 0.0015 0.0046
Leishmania major cathepsin L-like protease 0.0036 0.0071 0.0111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0277 0.0532
Echinococcus granulosus tar DNA binding protein 0.0073 0.0196 0.0377
Loa Loa (eye worm) hypothetical protein 0.0065 0.0168 0.0505
Toxoplasma gondii histone lysine methyltransferase SET1 0.0125 0.0371 0.3754
Plasmodium falciparum enoyl-acyl carrier reductase 0.0214 0.0667 0.4331
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0036 0.0071 0.046
Trypanosoma brucei NAD+ synthase, putative 0.0095 0.0269 0.0422
Brugia malayi hypothetical protein 0.0065 0.0168 0.0505
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0298 0.095 0.2853
Loa Loa (eye worm) hypothetical protein 0.0118 0.0345 0.1036
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.002 0.006
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0024 0.0071
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0016 0.0004 0.0006
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0064 0.0101
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0094 0.0148
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0015 0.0002 0.0006
Loa Loa (eye worm) inositol-1 0.0043 0.0094 0.0283
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0016 0.0004 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0406 0.0637
Schistosoma mansoni organic anion transporter 0.0129 0.0383 0.0734
Onchocerca volvulus 0.0027 0.0043 0.013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0666 0.218 1
Brugia malayi jmjC domain containing protein 0.0036 0.0071 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Echinococcus granulosus mitogen activated protein kinase 0.0116 0.034 0.0652
Echinococcus granulosus transcription factor btf3 0.004 0.0087 0.0166
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0094
Echinococcus multilocularis pol protein 0.3002 1 1
Brugia malayi Cathepsin L-like precursor 0.0036 0.0071 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0046
Onchocerca volvulus 0.0036 0.0071 0.0213
Leishmania major basic transcription factor 3a, putative 0.004 0.0087 0.0136
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.034 0.1555
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0053 0.0128 0.02
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0116 0.034 0.0534
Leishmania major cytochrome P450 reductase, putative 0.0122 0.036 0.0564
Trichomonas vaginalis sulfite reductase, putative 0.0138 0.0412 0.1886
Onchocerca volvulus 0.1009 0.3329 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0091 0.0174
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0087 0.0563
Schistosoma mansoni loxhd1 0.0065 0.0168 0.0323
Mycobacterium leprae Probable lipase LipE 0.0042 0.0091 0.0589
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0053 0.0128 0.0581
Brugia malayi hypothetical protein 0.0019 0.0014 0.0043
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0046
Brugia malayi multidrug resistance protein 3 0.0024 0.0033 0.0099
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0033 0.0335
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0015 0.0002 0.0006
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0013 0.0039
Entamoeba histolytica P-glyco protein 6, putative 0.0024 0.0033 0.0152
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0088 0.0246 0.0739
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0214 0.0667 0.2
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.006
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0016 0.0004 0.0012
Brugia malayi Cell death protein 3 precursor 0.0068 0.0179 0.0538
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.006
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.034 0.1555
Schistosoma mansoni zinc finger protein 0.0019 0.0015 0.0029
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0094 0.0613
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0001 0.000000000061058
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0015 0.0029
Mycobacterium ulcerans GMP synthase 0.0038 0.0078 0.0235
Echinococcus granulosus caspase 0.002 0.002 0.0038
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0347 0.0666
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.0033 0.0146
Brugia malayi hypothetical protein 0.0019 0.0015 0.0046
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.0095 0.0269 0.1229
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0013 0.002
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Echinococcus granulosus cathepsin L cysteine protease 0.0018 0.0013 0.0025
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0116 0.034 0.0534
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0015 0.0015
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0214 0.0667 0.4331
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0023 0.0069
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0016 0.0004 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0018 0.0013 0.002
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0214 0.0667 0.4331
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0071 0.0214
Echinococcus multilocularis mitogen activated protein kinase 3 0.0116 0.034 0.034
Schistosoma mansoni multidrug resistance protein 0.0024 0.0033 0.0063
Echinococcus multilocularis muscleblind protein 1 0.034 0.109 0.109
Loa Loa (eye worm) hypothetical protein 0.1009 0.3329 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0024 0.0033 0.0099
Leishmania major p-glycoprotein 0.0024 0.0033 0.0052
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0091 0.0272
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0071 0.0071
Mycobacterium ulcerans monooxygenase 0.0016 0.0004 0.0012
Toxoplasma gondii Alpha-galactosidase 0.0017 0.0008 0.0077
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0064 0.0193
Brugia malayi beta-lactamase family protein 0.0042 0.0091 0.0273
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0196 0.059
Trichomonas vaginalis glucosylceramidase, putative 0.0298 0.095 0.4353
Brugia malayi Doublecortin family protein 0.0065 0.0168 0.0505
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0277 0.0277
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0908 0.2991 0.4693
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0196 0.059
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.0095 0.0269 0.4034
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0015 0.0046
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0004 0.0066
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0015 0.0029
Schistosoma mansoni hypothetical protein 0.0932 0.307 0.5889
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0013 0.0025
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0053 0.0128 0.02
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.034 0.1555
Echinococcus multilocularis bloom syndrome protein 0.0023 0.003 0.003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0087 0.0166
Onchocerca volvulus 0.0065 0.0168 0.0505
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.0406 0.0637
Loa Loa (eye worm) diaphorase 0.0016 0.0004 0.0012
Brugia malayi Melibiase family protein 0.0079 0.0216 0.0648
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0214 0.0667 0.4331
Loa Loa (eye worm) hypothetical protein 0.0036 0.0071 0.0214
Loa Loa (eye worm) hypothetical protein 0.0129 0.0383 0.1149
Echinococcus granulosus geminin 0.0196 0.0606 0.1163
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0033 0.0146
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0015 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Echinococcus granulosus cathepsin l cysteine peptidase 0.0036 0.0071 0.0136
Loa Loa (eye worm) hypothetical protein 0.0068 0.0179 0.0538
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0043 0.0068
Schistosoma mansoni thyroid hormone receptor 0.004 0.0087 0.0166
Schistosoma mansoni cytochrome P450 reductase 0.0138 0.0412 0.0791
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.001 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0206 0.0642 0.294
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0086
Brugia malayi SPARC precursor 0.0088 0.0246 0.0739
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.002 0.0086
Treponema pallidum NAD synthetase 0.0095 0.0269 0.1218
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0031 0.0144
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0015 0.0002 0.0006
Schistosoma mansoni cytochrome B5 0.0016 0.0004 0.0008
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0474 0.154 0.4617
Echinococcus multilocularis pol protein 0.3002 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0043 0.0198
Trypanosoma brucei nitrate reductase, putative 0.0016 0.0004 0.0006
Leishmania major cytochrome p450-like protein 0.0034 0.0064 0.0101
Onchocerca volvulus 0.0042 0.0091 0.0273
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0015 0.0046
Trypanosoma cruzi metacaspase, putative 0.002 0.002 0.0031
Loa Loa (eye worm) jmjC domain-containing protein 0.0138 0.0412 0.1239
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.006
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0129 0.0383 0.0383
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.006
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0016 0.0004 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0071 0.032
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0329 0.1052 0.1651
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0091 0.0273
Entamoeba histolytica P-glycoprotein-2, putative 0.0024 0.0033 0.0152
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0091 0.0272
Loa Loa (eye worm) hypothetical protein 0.0129 0.0383 0.1149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0087 0.026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0046
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0016 0.0049
Trichomonas vaginalis hypothetical protein 0.0214 0.0667 0.3055
Brugia malayi Pre-SET motif family protein 0.0242 0.0761 0.2285
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0196 0.0377
Loa Loa (eye worm) hypothetical protein 0.0129 0.0383 0.1149
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0094
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0072 0.0138
Brugia malayi hypothetical protein 0.0021 0.0023 0.0069
Leishmania major cysteine peptidase A (CPA) 0.0036 0.0071 0.0111
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0087 0.026
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0138 0.0414
Leishmania major hypothetical protein, conserved 0.0029 0.0049 0.0077
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0079 0.0238
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0016 0.0004 0.0006
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0168 0.0168
Brugia malayi tailless protein 0.0019 0.0015 0.0046
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0266 0.0841 0.2521
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0053 0.0128 0.083
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0087 0.026
Schistosoma mansoni hypothetical protein 0.0065 0.0168 0.0323
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0666 0.218 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0087 0.0166
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0094 0.0094
Plasmodium vivax multidrug resistance protein 1, putative 0.0024 0.0033 0.0496
Plasmodium vivax JmjC domain containing protein 0.0036 0.0071 0.1067
Toxoplasma gondii flavodoxin domain-containing protein 0.0068 0.018 0.1824
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0071 0.0112
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0043 0.013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0046
Leishmania major NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Trypanosoma brucei Metacaspase-4 0.002 0.002 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0053 0.0128 0.1916
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0023 0.0069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0001 0.000000000061058
Onchocerca volvulus 0.0042 0.0091 0.0273
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0038 0.0078 0.0123
Echinococcus multilocularis 0.0015 0.0002 0.0002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0015 0.0029
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0015 0.0002 0.0006
Plasmodium falciparum JmjC domain-containing protein, putative 0.0036 0.0071 0.0462
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0033 0.0146
Mycobacterium tuberculosis Conserved protein 0.0042 0.0091 0.0272
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0094 0.0148
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0016 0.0004 0.0006
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0087 0.0087
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0474 0.154 1
Brugia malayi RNA binding protein 0.0073 0.0196 0.059
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0087 0.026
Entamoeba histolytica hypothetical protein 0.0042 0.0091 0.0416
Loa Loa (eye worm) hypothetical protein 0.0088 0.0246 0.0739
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0087 0.026
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0013 0.006
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0122 0.036 0.1646
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0024 0.0033 0.0335
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0013 0.002
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0015 0.0029
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0038 0.0078 0.0795
Brugia malayi beta-NAC-like protein 0.004 0.0087 0.026
Entamoeba histolytica P-glycoprotein-2 0.0024 0.0033 0.0152
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0001 0.000000000061058
Brugia malayi secreted modular calcium-binding protein 1 0.0088 0.0246 0.0739
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0043 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0043 0.013
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0016 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0065 0.0168 0.0505
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0071 0.0213
Echinococcus granulosus cathepsin L 0.0018 0.0013 0.0025
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0072 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0087 0.026
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0007 0.0014
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0033 0.0063
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0138 0.0412 0.0647
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0091 0.0174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0071 0.032
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0015 0.0002 0.0006
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0087 0.0166
Echinococcus granulosus Solute carrier organic anion transporter family 0.0129 0.0383 0.0734
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0033 0.0033
Leishmania major hypothetical protein, conserved 0.0042 0.0091 0.0142
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0046
Trichomonas vaginalis esterase, putative 0.0042 0.0091 0.0411
Brugia malayi Cathepsin L-like precursor 0.0024 0.0031 0.0094
Mycobacterium tuberculosis Conserved hypothetical protein 0.1011 0.3335 1
Plasmodium vivax unspecified product 0.0018 0.0013 0.0195
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0001 0.000000000061058
Echinococcus multilocularis expressed protein 0.0088 0.0246 0.0246
Echinococcus multilocularis pol protein 0.3002 1 1
Schistosoma mansoni nuclear hormone receptor 0.004 0.0087 0.0166
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0013 0.0025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0138 0.0412 0.0791
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0091 0.0272
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0091 0.0142
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0116 0.034 0.0534
Plasmodium falciparum metacaspase-like protein 0.002 0.002 0.013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.013
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.002 0.0086
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0015 0.0002 0.0006
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0015 0.0002 0.0006
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0094 0.0427
Echinococcus granulosus Ankyrin 0.0017 0.0008 0.0015
Schistosoma mansoni microtubule-associated protein tau 0.1572 0.5213 1
Echinococcus granulosus dnaJ subfamily B 0.0932 0.307 0.5889
Onchocerca volvulus 0.0016 0.0004 0.0012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0091 0.0174
Brugia malayi Muscleblind-like protein 0.034 0.109 0.3276
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.006
Brugia malayi FAD binding domain containing protein 0.0138 0.0412 0.1238
Onchocerca volvulus 0.0129 0.0383 0.1149
Brugia malayi nuclear receptor NHR-88 0.004 0.0087 0.026
Brugia malayi Cytochrome P450 family protein 0.0056 0.0138 0.0414
Onchocerca volvulus Putative organic anion transporter 0.0129 0.0383 0.1149
Brugia malayi CXXC zinc finger family protein 0.0065 0.0171 0.0512
Echinococcus granulosus cytochrome b5 reductase 4 0.0016 0.0004 0.0008
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.002 0.002 0.0038
Mycobacterium ulcerans NAD synthetase 0.0095 0.0269 0.0807
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Trypanosoma cruzi metacaspase, putative 0.002 0.002 0.0031
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.002 0.0086
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0091 0.1361
Schistosoma mansoni cpg binding protein 0.0069 0.0183 0.0351
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0087 0.026
Onchocerca volvulus 0.0275 0.0872 0.2621
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0064 0.0193
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0069
Schistosoma mansoni organic anion transporter 0.0129 0.0383 0.0734
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.002 0.0086
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0474 0.154 1
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0138 0.0412 0.0791
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0606 0.2778
Brugia malayi conserved hypotetical protein 0.0019 0.0015 0.0046
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0091 0.0411
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0064 0.0101
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.006
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0091 0.0272
Onchocerca volvulus 0.0036 0.0071 0.0213
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0087 0.026
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0008 0.0016
Mycobacterium leprae putative cytochrome p450 0.0015 0.0002 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0406 0.0637
Entamoeba histolytica hypothetical protein 0.0042 0.0091 0.0416
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0138 0.0412 0.6181
Loa Loa (eye worm) hypothetical protein 0.0036 0.0071 0.0214
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.002 0.002 0.0038
Loa Loa (eye worm) hypothetical protein 0.004 0.0087 0.026
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0038 0.0078 0.0123
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0087 0.0398
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0406 0.0637
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0091 0.0411
Trypanosoma cruzi cruzipain precursor, putative 0.0136 0.0406 0.0637
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0007 0.0021
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0016 0.0004 0.0059
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0015 0.0002 0.0006
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0018 0.0013 0.0025
Toxoplasma gondii NAC domain-containing protein 0.004 0.0087 0.0878
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0015 0.0002 0.0006
Trypanosoma cruzi p450 reductase, putative 0.0016 0.0004 0.0006
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.002 0.002 0.002
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0033 0.0146
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0039 0.0084 0.0084
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.0033 0.0146
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0015 0.0029
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0016 0.0004 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0071 0.032
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0049 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0087 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0087 0.0166
Echinococcus granulosus cytochrome b5 reductase 4 0.0016 0.0004 0.0008
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0116 0.034 0.0534
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0091 0.0272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0031 0.0139
Schistosoma mansoni polycystin 1-related 0.0065 0.0168 0.0323
Echinococcus multilocularis caspase 0.002 0.002 0.002
Echinococcus multilocularis muscleblind protein 0.034 0.109 0.109
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0347 0.0666
Mycobacterium ulcerans electron transfer protein FdxB 0.0016 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0046
Schistosoma mansoni lozenge 0.0127 0.0375 0.072
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.002 0.0131
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0071 0.0071
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0033 0.0146
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0033 0.0033
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0088 0.0246 0.0739
Echinococcus granulosus cathepsin l1 0.0036 0.0071 0.0136
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.04 0.1203
Onchocerca volvulus 0.0129 0.0383 0.1149
Schistosoma mansoni netrin receptor unc5 0.0017 0.0007 0.0014
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0023 0.0023
Brugia malayi Death domain containing protein 0.0017 0.0007 0.0021
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0033 0.0146
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0094 0.0955
Schistosoma mansoni GMP synthetase 0.0038 0.0078 0.0151
Schistosoma mansoni cytochrome P450 0.0015 0.0002 0.0004
Brugia malayi Uncoordinated protein 44 0.0017 0.0007 0.0021
Echinococcus granulosus jumonji domain containing 1A 0.0036 0.0071 0.0136
Brugia malayi nuclear receptor RXR 0.0019 0.0015 0.0046
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0002 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0206 0.0642 0.294
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0071 0.0325
Entamoeba histolytica type A flavoprotein, putative 0.0053 0.0128 0.0586
Brugia malayi hypothetical protein 0.0065 0.0168 0.0505
Echinococcus multilocularis jumonji domain containing 1A 0.0036 0.0071 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0406 0.0637
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0015 0.0002 0.0006
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0085 0.0236 0.0453
Leishmania major cytochrome-b5 reductase, putative 0.0016 0.0004 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0298 0.095 0.4353
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0015 0.0002 0.0006
Schistosoma mansoni diflavin oxidoreductase 0.0068 0.018 0.0345
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0474 0.154 0.7057
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0168 0.0323
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0071 0.0136
Trypanosoma brucei NADH-dependent fumarate reductase 0.0016 0.0004 0.0006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0004 0.0038
Schistosoma mansoni smdr2 0.0024 0.0033 0.0063
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0015 0.0002 0.0006
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0033 0.0146
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0023 0.0044
Plasmodium vivax hypothetical protein, conserved 0.002 0.002 0.0299
Loa Loa (eye worm) hypothetical protein 0.004 0.0087 0.026
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0087 0.026
Trichomonas vaginalis abcb9, putative 0.0024 0.0033 0.0146
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0007 0.0021
Leishmania major cytochrome-b5 reductase, putative 0.0016 0.0004 0.0006
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0015 0.0046
Trypanosoma cruzi nitrate reductase, putative 0.0016 0.0004 0.0006
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0079 0.0515
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1918 0.6374 1
Treponema pallidum flavodoxin 0.0053 0.0128 0.0569
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0033 0.0146
Echinococcus granulosus cpg binding protein 0.0069 0.0183 0.0351
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0406 0.0637
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0023 0.0044
Entamoeba histolytica hypothetical protein 0.0042 0.0091 0.0416
Schistosoma mansoni caspase-7 (C14 family) 0.002 0.002 0.0038
Schistosoma mansoni hypothetical protein 0.0196 0.0606 0.1163
Trypanosoma brucei protein kinase, putative 0.0116 0.034 0.0534
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0054
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1918 0.6374 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0046
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0015 0.0002 0.0006
Brugia malayi hypothetical protein 0.0029 0.0049 0.0147
Onchocerca volvulus Cell death protein 3 homolog 0.0068 0.0179 0.0538
Mycobacterium ulcerans hypothetical protein 0.0042 0.0091 0.0272
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.006
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.006
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0053 0.0128 0.0581
Schistosoma mansoni inositol monophosphatase 0.0043 0.0094 0.0181
Schistosoma mansoni lipoxygenase 0.0254 0.08 0.1536
Brugia malayi hypothetical protein 0.0048 0.0111 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Echinococcus multilocularis cpg binding protein 0.0069 0.0183 0.0183
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0087 0.0087
Echinococcus granulosus microtubule associated protein 2 0.1572 0.5213 1
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0606 0.2778
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0254 0.08 0.08
Toxoplasma gondii ABC1 family protein 0.0042 0.0091 0.0919
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0196 0.0377
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0606 0.2778
Entamoeba histolytica cysteine proteinase 1, putative 0.0018 0.0013 0.006
Schistosoma mansoni serine/threonine protein kinase 0.0116 0.034 0.0652
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0091 0.0272
Echinococcus multilocularis Protein lozenge 0.0127 0.0375 0.0375
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0015 0.0002 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0072 0.0138
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.002 0.006
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0033 0.0146
Trichomonas vaginalis taga, putative 0.0024 0.0033 0.0146
Leishmania major cytochrome p450-like protein 0.0015 0.0002 0.0003
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0015 0.0002 0.0006
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.004 0.0087 0.026
Loa Loa (eye worm) CXXC zinc finger family protein 0.0065 0.0171 0.0512
Plasmodium vivax metacaspase 1, putative 0.002 0.002 0.0299
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0043 0.0068
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0474 0.154 1
Leishmania major cathepsin L-like protease 0.0136 0.0406 0.0637
Schistosoma mansoni hypothetical protein 0.0042 0.0091 0.0174
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.0406 0.0637
Entamoeba histolytica type A flavoprotein, putative 0.0053 0.0128 0.0586
Giardia lamblia NH3-dependent NAD+ synthetase 0.0095 0.0269 0.1218
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0236
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0087 0.0166
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0138 0.0412 0.0647
Toxoplasma gondii flavodoxin domain-containing protein 0.0068 0.018 0.1824
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0118 0.0347 0.0666
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0606 0.2778
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.001 0.002
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0908 0.2991 0.4693
Trypanosoma cruzi oxidoreductase-protein, putative 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0273
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0097
Mycobacterium tuberculosis Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) 0.0095 0.0269 0.0807
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0053 0.0128 0.0581
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0087 0.0087
Onchocerca volvulus 0.0065 0.0168 0.0505
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0087 0.026
Trypanosoma brucei oxidoreductase-protein, putative 0.0016 0.0004 0.0006
Leishmania major cathepsin L-like protease 0.0036 0.0071 0.0111
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.003 0.0131
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.002 0.0086
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0138 0.0412 0.0647
Loa Loa (eye worm) hypothetical protein 0.0138 0.0412 0.1238
Onchocerca volvulus Putative organic anion transporter 0.0129 0.0383 0.1149
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0666 0.218 1
Brugia malayi hypothetical protein 0.1009 0.3329 1
Mycobacterium tuberculosis Conserved protein 0.0042 0.0091 0.0272
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0666 0.218 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0033 0.0146
Brugia malayi hypothetical protein 0.0273 0.0865 0.26
Echinococcus granulosus lysine specific demethylase 6a 0.0036 0.0071 0.0136
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0042
Brugia malayi hypothetical protein 0.0019 0.0015 0.0046
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0046
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0053 0.0128 0.083
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0196 0.0377
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0016 0.0004 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0406 0.0637
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.0031 0.0094
Toxoplasma gondii hypothetical protein 0.0309 0.0987 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0094 0.0148
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0116 0.034 0.3444
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0071 0.032
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0273
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0129 0.0383 0.0383
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0015 0.0029
Brugia malayi sodium-independent organic anion transporter family protein 0.0129 0.0383 0.1149
Loa Loa (eye worm) runx1 0.0127 0.0375 0.1127
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0032 0.0032
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Schistosoma mansoni survival motor neuron protein 0.0056 0.0138 0.0265
Onchocerca volvulus 0.0036 0.0071 0.0213
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0043 0.013
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0017 0.0008 0.0033
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0016 0.0004 0.0006
Brugia malayi ecdysone receptor 0.0019 0.0015 0.0046
Echinococcus multilocularis cytochrome b5 reductase 4 0.0016 0.0004 0.0004
Treponema pallidum fructose-bisphosphate aldolase 0.0666 0.218 1
Loa Loa (eye worm) RNA binding protein 0.0073 0.0196 0.059
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0033 0.0063
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0087 0.0166
Schistosoma mansoni multidrug resistance protein 0.0024 0.0033 0.0063
Brugia malayi flavodoxin family protein 0.0053 0.0128 0.0384
Loa Loa (eye worm) ICD-1 protein 0.004 0.0087 0.026
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0049 0.0496
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0015 0.0002 0.0006
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0024 0.0032 0.0062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0015 0.0029
Echinococcus multilocularis mitogen activated protein kinase 0.0116 0.034 0.034
Schistosoma mansoni rab6-interacting 0.0065 0.0168 0.0323
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0024 0.0024
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0071 0.0112
Brugia malayi hypothetical protein 0.0042 0.0091 0.0272
Trichomonas vaginalis CMGC family protein kinase 0.0116 0.034 0.1555
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0024 0.0033 0.0052
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0087 0.026
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0015 0.0029
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0013 0.006
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0033 0.0063
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0002 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.0071 0.0111
Entamoeba histolytica hypothetical protein 0.004 0.0087 0.0398
Echinococcus granulosus JmjC domain containing protein 4 0.0036 0.0071 0.0136
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0036 0.0071 0.0112
Loa Loa (eye worm) hypothetical protein 0.0129 0.0383 0.1149
Brugia malayi sodium-independent organic anion transporter family protein 0.0129 0.0383 0.1149
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0049 0.0318
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0015 0.0015
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0007 0.0014
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0033 0.0033
Brugia malayi jmjC domain containing protein 0.0134 0.04 0.1202
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0016 0.0049
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0138 0.0412 0.0412
Mycobacterium ulcerans oxygenase 0.0016 0.0004 0.0012
Loa Loa (eye worm) FAD binding domain-containing protein 0.0138 0.0412 0.1238
Schistosoma mansoni jumonji domain containing protein 0.0134 0.04 0.0767
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0015 0.0002 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0298 0.095 0.4353
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0001 0.000000000061058
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0087 0.0392
Loa Loa (eye worm) doublecortin family protein 0.0065 0.0168 0.0505
Trypanosoma cruzi metacaspase, putative 0.002 0.002 0.0031
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0087 0.0166
Echinococcus granulosus muscleblind protein 0.034 0.109 0.2092
Brugia malayi Cytochrome P450 family protein 0.0015 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0046
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0033 0.0146
Mycobacterium tuberculosis Possible oxygenase 0.0016 0.0004 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0086
Brugia malayi Cytochrome P450 family protein 0.0034 0.0064 0.0193
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.002 0.0202
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0273
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0043 0.0281
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0024 0.0045
Trichomonas vaginalis glucosylceramidase, putative 0.0298 0.095 0.4353
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0033 0.0146
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0087 0.026
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0087 0.0392
Schistosoma mansoni hypothetical protein 0.0056 0.0138 0.0265
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0406 0.0637
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0036 0.0071 0.0213
Schistosoma mansoni hypothetical protein 0.0111 0.0325 0.0623
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0087 0.026
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0116 0.034 0.0534
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0015 0.0002 0.0006
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0273
Brugia malayi jmjC domain containing protein 0.0036 0.0071 0.0214
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0273
Brugia malayi MAP kinase sur-1 0.0116 0.034 0.1022
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0666 0.218 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0666 0.218 1
Plasmodium vivax vivapain-3 0.0018 0.0013 0.0195
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0138 0.0412 0.1236
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0002 0.0003
Toxoplasma gondii cathepsin CPL 0.0036 0.0071 0.0717
Leishmania major oxidoreductase-like protein 0.0016 0.0004 0.0006
Trypanosoma cruzi MFS transporter, putative 0.0129 0.0383 0.06
Loa Loa (eye worm) hypothetical protein 0.004 0.0087 0.026
Giardia lamblia Hypothetical protein 0.0122 0.036 0.1635
Schistosoma mansoni glutaminase 0.0316 0.1008 0.1934
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.0095 0.0269 0.2724
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.006
Echinococcus multilocularis methionine synthase reductase 0.0085 0.0236 0.0236
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0095 0.0269 0.0516
Giardia lamblia Fructose-bisphosphate aldolase 0.0666 0.218 1
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0014
Plasmodium vivax flavodoxin domain containing protein 0.0122 0.036 0.5396
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0087 0.0087
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0064 0.0101
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0134 0.04 0.0767
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0015 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0046
Echinococcus multilocularis cysteine protease 0.0036 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0048 0.0111 0.0213
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0325 0.104 0.6756
Brugia malayi Pre-SET motif family protein 0.0036 0.0072 0.0215
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0094 0.0148
Brugia malayi ABC transporter family protein 0.0024 0.0033 0.0099
Mycobacterium ulcerans lipase LipD 0.0042 0.0091 0.0272
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0002 0.0003
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0036 0.0071 0.072
Brugia malayi beta-lactamase 0.0042 0.0091 0.0273
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0088 0.0246 0.0739
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.002 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0666 0.218 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0069
Echinococcus granulosus phd:f box containing protein 0.0036 0.0071 0.0136
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.027 0.0855 0.1341
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.0865 0.166
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0138 0.0412 0.0647
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0018 0.0013 0.002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0273
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0043 0.013
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0039 0.0084 0.016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0046
Entamoeba histolytica cysteine protease, putative 0.0036 0.0071 0.0325
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0016 0.0004 0.0004
Echinococcus multilocularis dnaJ subfamily B 0.0932 0.307 0.307
Brugia malayi Protein kinase domain containing protein 0.0018 0.0011 0.0032
Echinococcus granulosus death domain containing protein 0.0017 0.0007 0.0014
Brugia malayi prostaglandin transporter 0.0129 0.0383 0.1149
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0091 0.0272
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0087 0.0087
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0015 0.0046
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0088 0.0246 0.249
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0087 0.026
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0049 0.0735
Echinococcus multilocularis lipoxygenase domain containing protein 0.0065 0.0168 0.0168
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.027 0.0855 0.1341
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0091 0.0411
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0087 0.0392
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0016 0.0004 0.0012
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0091 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0086
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0094 0.0433
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0063 0.012
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0015 0.0046
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.001 0.002
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0049 0.0077
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.0865 0.0865
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0129 0.0383 0.0734
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.006
Leishmania major hypothetical protein, conserved 0.0053 0.0128 0.02
Brugia malayi hypothetical protein 0.0021 0.0023 0.0069
Trypanosoma cruzi NAD+ synthase, putative 0.0095 0.0269 0.0422
Schistosoma mansoni follistatin 0.0088 0.0246 0.0472
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0666 0.218 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0072 0.0138
Onchocerca volvulus Cathepsin F homolog 0.0036 0.0071 0.0213
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0015 0.0002 0.0006
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0094 0.0283
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0118 0.0347 0.0347
Schistosoma mansoni hypothetical protein 0.0196 0.0606 0.1163
Brugia malayi FAD binding domain containing protein 0.0085 0.0236 0.0709
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0023 0.0069
Brugia malayi MH2 domain containing protein 0.0134 0.04 0.1203
Brugia malayi glutaminase DH11.1 0.0316 0.1008 0.3028
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0606 0.2778
Echinococcus granulosus lipoxygenase domain containing protein 0.0065 0.0168 0.0323
Plasmodium falciparum cysteine proteinase falcipain 3 0.0036 0.0071 0.046
Onchocerca volvulus 0.0129 0.0383 0.1149
Mycobacterium tuberculosis Probable monooxygenase 0.0016 0.0004 0.0012
Loa Loa (eye worm) hypothetical protein 0.0088 0.0246 0.0739
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0013 0.006
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0015 0.0002 0.0006
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0015 0.0002 0.0006
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0094 0.0427
Plasmodium falciparum metacaspase 1 0.002 0.002 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0087 0.026
Loa Loa (eye worm) hypothetical protein 0.0036 0.0071 0.0213
Brugia malayi TAR-binding protein 0.0073 0.0196 0.059
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0087 0.0166
Loa Loa (eye worm) hypothetical protein 0.0048 0.0111 0.0333
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0033 0.0063
Schistosoma mansoni transcription factor btf3 0.004 0.0087 0.0166
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0015 0.0002 0.0006
Trypanosoma brucei DNA polymerase beta thumb, putative 0.027 0.0855 0.1341
Echinococcus multilocularis caspase 2 0.0068 0.0179 0.0179
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0064 0.0193
Brugia malayi nuclear receptor NHR-67 0.0019 0.0015 0.0046
Entamoeba histolytica hypothetical protein 0.0042 0.0091 0.0416
Loa Loa (eye worm) glutaminase 0.0316 0.1008 0.3028
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0196 0.059
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0138 0.0412 0.0647
Plasmodium vivax vivapain-2 0.0036 0.0071 0.1062
Trypanosoma brucei RNA helicase, putative 0.0111 0.0325 0.0509
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0015 0.0002 0.0006
Leishmania major mitochondrial DNA polymerase beta 0.1918 0.6374 1
Trypanosoma cruzi metacaspase, putative 0.002 0.002 0.0031
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0033 0.0033
Brugia malayi Cathepsin L-like precursor 0.0036 0.0071 0.0213
Mycobacterium tuberculosis Probable oxidoreductase 0.0016 0.0004 0.0012
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0091 0.0174
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0071 0.0214
Brugia malayi jmjC domain containing protein 0.0138 0.0412 0.1239
Trypanosoma brucei metacaspase 0.002 0.002 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0091 0.0411
Onchocerca volvulus 0.0019 0.0015 0.0046
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0091 0.0174
Plasmodium falciparum cysteine proteinase falcipain 1 0.0018 0.0013 0.0084
Schistosoma mansoni agrin 0.0088 0.0246 0.0472
Onchocerca volvulus 0.0036 0.0072 0.0215
Brugia malayi GMP synthase 0.0038 0.0078 0.0236
Plasmodium falciparum nitric oxide synthase, putative 0.0138 0.0412 0.2677
Brugia malayi cathepsin L-like precursor 0.0024 0.0031 0.0094
Giardia lamblia Kinase, CMGC MAPK 0.0116 0.034 0.1545
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.006
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0071 0.0136
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0087 0.0166
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0043 0.013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0046
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0036 0.0071 0.072
Echinococcus granulosus mitogen activated protein kinase 3 0.0116 0.034 0.0652
Loa Loa (eye worm) hypothetical protein 0.0088 0.0246 0.0739
Echinococcus multilocularis cathepsin L 0.0018 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.013
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0007 0.0021
Entamoeba histolytica P-glycoprotein-1 0.0024 0.0033 0.0152
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0015 0.0046
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0016 0.0004 0.0006
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0017 0.0008 0.0015
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0474 0.154 1
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0007 0.0007
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0091 0.0142
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0043 0.013
Leishmania major NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0133 0.0396 0.0396
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.0095 0.0269 0.1747
Echinococcus multilocularis caspase 8 0.002 0.002 0.002
Schistosoma mansoni cpg binding protein 0.0069 0.0183 0.0351
Schistosoma mansoni thyroid hormone receptor 0.004 0.0087 0.0166
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0043 0.0068
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0071 0.0213
Brugia malayi nuclear receptor RXR 0.0021 0.0023 0.0069
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0023 0.0068
Leishmania major cathepsin L-like protease 0.0036 0.0071 0.0111
Leishmania major cathepsin L-like protease 0.0036 0.0071 0.0111
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0024 0.0033 0.0099
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0057 0.0142 0.0273
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0071 0.032
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0666 0.218 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0015 0.0002 0.0006
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0033 0.0146
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.002 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0024 0.0031 0.0094
Leishmania major cathepsin L-like protease 0.0136 0.0406 0.0637
Echinococcus multilocularis Polycystic kidney disease protein 0.0065 0.0168 0.0168
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0087 0.0136
Echinococcus multilocularis phd:f box containing protein 0.0036 0.0071 0.0071
Loa Loa (eye worm) RecQ helicase 0.0023 0.003 0.0089
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0406 0.0637
Schistosoma mansoni rab6-interacting 0.0065 0.0168 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0071 0.032
Echinococcus granulosus cysteine protease 0.0018 0.0013 0.0025
Loa Loa (eye worm) hypothetical protein 0.1009 0.3329 1
Schistosoma mansoni nuclear receptor 0.0019 0.0015 0.0029
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0043 0.0198
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0015 0.0002 0.0006
Schistosoma mansoni jumonji domain containing protein 0.0036 0.0071 0.0136
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0129 0.0383 0.1149
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.002 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0087 0.026
Loa Loa (eye worm) agrin synaptic family protein 0.0088 0.0246 0.0739
Entamoeba histolytica type A flavoprotein, putative 0.0053 0.0128 0.0586
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.002 0.03
Echinococcus granulosus bloom syndrome protein 0.0023 0.003 0.0057
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0091 0.0091
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0072 0.0072
Trypanosoma brucei metacaspase MCA3 0.002 0.002 0.0031
Entamoeba histolytica cysteine proteinase 2 0.0018 0.0013 0.006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0277 0.0833
Schistosoma mansoni multidrug resistance protein 0.0024 0.0033 0.0063
Schistosoma mansoni phosphatidylserine receptor 0.0036 0.0071 0.0136
Brugia malayi Cathepsin L-like precursor 0.0024 0.0031 0.0094
Trichomonas vaginalis abcb9, putative 0.0024 0.0033 0.0146
Loa Loa (eye worm) hypothetical protein 0.0036 0.0071 0.0214
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0016 0.0004 0.0012
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0038 0.0078 0.051
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0016 0.0004 0.0006
Trichomonas vaginalis abcb9, putative 0.0024 0.0033 0.0146
Brugia malayi Cathepsin L-like precursor 0.0036 0.0071 0.0213
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0016 0.0004 0.0006
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0016 0.0004 0.0006
Echinococcus multilocularis Ankyrin 0.0017 0.0008 0.0008
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0087 0.13
Brugia malayi cytochrome P450 0.0015 0.0002 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0031 0.0139
Onchocerca volvulus 0.004 0.0087 0.026
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0015 0.0015
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0053 0.0128 0.02
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0094 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0087 0.026
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0015 0.0002 0.0006
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0474 0.154 0.4617
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0116 0.034 0.0534
Schistosoma mansoni protein phosphatase 2C 0.0036 0.0071 0.0136
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0015 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0087 0.026
Onchocerca volvulus 0.0048 0.0111 0.0333
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0079 0.0216 0.0984
Trypanosoma cruzi major cysteine proteinase, putative 0.0107 0.0309 0.0484
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0277 0.0532
Loa Loa (eye worm) hypothetical protein 0.0088 0.0246 0.0739
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0088 0.0246 0.249
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0088 0.0246 0.249
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0033 0.0146
Loa Loa (eye worm) hypothetical protein 0.0129 0.0383 0.1149
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.006
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0043 0.013
Loa Loa (eye worm) hypothetical protein 0.004 0.0087 0.026
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0033 0.0146
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0031 0.006
Entamoeba histolytica type A flavoprotein, putative 0.0053 0.0128 0.0586
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0015 0.0002 0.0006
Echinococcus granulosus FTZ F1 alpha 0.004 0.0087 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0406 0.0637
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0046
Trypanosoma cruzi cysteine proteinase, putative 0.0018 0.0013 0.002
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0016 0.0004 0.004
Mycobacterium tuberculosis Conserved protein 0.0042 0.0091 0.0272
Brugia malayi ecdysteroid receptor 0.004 0.0087 0.026
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.0406 0.0637
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0043 0.0198
Leishmania major NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0033 0.0146
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0154 0.0468 0.0897
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0015 0.0015
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.04 0.1203
Brugia malayi hypothetical protein 0.0129 0.0383 0.1149
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.006
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.002 0.0086
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0087 0.0166
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0036 0.0071 0.0136
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0087 0.0166
Loa Loa (eye worm) glutaminase 2 0.0316 0.1008 0.3028
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.002 0.002 0.006
Plasmodium vivax GMP synthetase, putative 0.0038 0.0078 0.1177
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0038 0.0078 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0071 0.032
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0214 0.0667 0.6752
Echinococcus granulosus caspase 8 0.002 0.002 0.0038
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0138 0.0412 0.0791
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0087 0.026
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0347 0.0666
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0196 0.0377
Leishmania major nitrate reductase, putative 0.0016 0.0004 0.0006
Plasmodium vivax vivapain-1 0.0018 0.0013 0.0195
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0015 0.0002 0.0006
Echinococcus granulosus RUN 0.0065 0.0168 0.0323
Mycobacterium ulcerans hypothetical protein 0.1011 0.3335 1
Entamoeba histolytica NAD synthetase, putative 0.0095 0.0269 0.1234
Loa Loa (eye worm) hypothetical protein 0.0129 0.0383 0.1149
Echinococcus multilocularis lysine specific demethylase 5A 0.0134 0.04 0.04
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0091 0.0272
Loa Loa (eye worm) cytochrome P450 0.0015 0.0002 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0049 0.0077
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0214 0.0667 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0071 0.032
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0071 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0086
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0036 0.0071 0.046
Echinococcus granulosus follistatin 0.0088 0.0246 0.0472
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0033 0.0146
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0071 0.032
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0013 0.0039
Brugia malayi Cathepsin L-like precursor 0.0036 0.0071 0.0213
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0015 0.0002 0.0006
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0087 0.0136
Plasmodium falciparum ferredoxin--NADP reductase 0.0016 0.0004 0.0025
Leishmania major p450 reductase, putative 0.0138 0.0412 0.0647
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0325 0.104 0.3119
Mycobacterium ulcerans hypothetical protein 0.0027 0.0043 0.013
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0072 0.0726
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0116 0.034 0.1022
Loa Loa (eye worm) fibroinase 0.0036 0.0071 0.0213
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0015 0.0002 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0072 0.0138
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0196 0.0196
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0216 0.0413
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0016 0.0004 0.004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0072 0.0215
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0147
Echinococcus granulosus cathepsin l1 0.0024 0.0031 0.006
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.006
Entamoeba histolytica type A flavoprotein, putative 0.0053 0.0128 0.0586
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0021
Plasmodium falciparum multidrug resistance protein 1 0.0024 0.0033 0.0215
Echinococcus granulosus agrin 0.0088 0.0246 0.0472
Brugia malayi nuclear hormone receptor 0.0019 0.0015 0.0046
Brugia malayi Cytochrome P450 family protein 0.0034 0.0064 0.0193
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0091 0.0142
Onchocerca volvulus 0.0019 0.0015 0.0046
Schistosoma mansoni inositol monophosphatase 0.0043 0.0094 0.0181
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0053 0.0128 0.0581
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0277 0.0532
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0087 0.026
Toxoplasma gondii protease inhibitor PI2 0.0088 0.0246 0.249
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0007 0.0014
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0087 0.0166
Echinococcus granulosus caspase 2 0.0068 0.0179 0.0344
Giardia lamblia Nitric oxide synthase, inducible 0.0122 0.036 0.1635
Loa Loa (eye worm) hypothetical protein 0.0027 0.0043 0.013
Echinococcus granulosus methionine synthase reductase 0.0085 0.0236 0.0453
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0088 0.0246 0.249
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0091 0.0091
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1918 0.6374 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0024 0.0033 0.0099
Echinococcus multilocularis RUN 0.0065 0.0168 0.0168
Brugia malayi beta-lactamase family protein 0.0042 0.0091 0.0273
Brugia malayi sodium-independent organic anion transporter family protein 0.0129 0.0383 0.1149
Trypanosoma brucei NADH-dependent fumarate reductase 0.0016 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0087 0.026
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.002 0.013
Loa Loa (eye worm) hypothetical protein 0.034 0.109 0.3276
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0015 0.0002 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0606 0.2778
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0138 0.0415
Onchocerca volvulus 0.0024 0.0031 0.0094
Loa Loa (eye worm) hypothetical protein 0.0129 0.0383 0.1149
Onchocerca volvulus 0.0036 0.0071 0.0213
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0043 0.0281
Loa Loa (eye worm) hypothetical protein 0.0079 0.0216 0.0648
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Echinococcus multilocularis transcription factor btf3 0.004 0.0087 0.0087
Brugia malayi hypothetical protein 0.0129 0.0383 0.1149
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0086
Echinococcus multilocularis JmjC domain containing protein 4 0.0036 0.0071 0.0071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0277 0.0277
Onchocerca volvulus Putative organic anion transporter 0.0129 0.0383 0.1149
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0908 0.2991 0.4693
Onchocerca volvulus 0.0024 0.0033 0.0099
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0134 0.04 0.04
Leishmania major cathepsin L-like protease 0.0036 0.0071 0.0111
Brugia malayi Cathepsin L-like precursor 0.0036 0.0071 0.0213
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.003 0.0089
Toxoplasma gondii melibiase subfamily protein 0.0118 0.0347 0.3518
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0043 0.013
Schistosoma mansoni retinoic acid receptor RXR 0.0154 0.0468 0.0897
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.006
Brugia malayi jmjC domain containing protein 0.0036 0.0071 0.0214
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0094 0.0427
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0033 0.0063
Trypanosoma cruzi p450 reductase, putative 0.0138 0.0412 0.0647
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0033 0.0146
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0277 0.0833
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0087 0.0166
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0015 0.0002 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.0138 0.0412 0.0791
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0116 0.034 0.0534
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0087 0.0087
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0033 0.0146
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0007 0.0007
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0049 0.0077
Loa Loa (eye worm) hypothetical protein 0.0273 0.0865 0.26
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0064 0.0193
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0002 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0277 0.0532
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0033 0.0033
Brugia malayi Inositol-1 0.0043 0.0094 0.0283
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0277 0.0532
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0016 0.0004 0.0006
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0015 0.0029
Onchocerca volvulus 0.0056 0.0138 0.0415
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0015 0.0002 0.0006
Plasmodium falciparum LCCL domain-containing protein 0.0065 0.0168 0.1092
Trypanosoma cruzi cysteine protease, putative 0.0018 0.0013 0.002
Brugia malayi diaphorase 0.0016 0.0004 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0298 0.095 0.4353
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0087 0.026
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0015 0.0002 0.0006
Leishmania major NAD synthase, putative 0.0095 0.0269 0.0422
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0015 0.0002 0.0006
Brugia malayi Cathepsin L-like precursor 0.0036 0.0071 0.0213
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0138 0.0412 0.0647
Onchocerca volvulus Glucosylceramidase homolog 0.0196 0.0606 0.1822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0054
Echinococcus multilocularis agrin 0.0088 0.0246 0.0246
Brugia malayi nuclear receptor NHR-88 0.0019 0.0015 0.0046
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0214 0.0667 0.2
Echinococcus multilocularis geminin 0.0196 0.0606 0.0606
Loa Loa (eye worm) hypothetical protein 0.004 0.0087 0.026
Loa Loa (eye worm) hypothetical protein 0.004 0.0087 0.026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0001 0.000000000061058
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0008 0.0016
Trypanosoma cruzi NAD+ synthase, putative 0.0095 0.0269 0.0422
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0325 0.104 0.3119
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0033 0.0146
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0254 0.08 0.1536
Schistosoma mansoni caspase-7 (C14 family) 0.0068 0.0179 0.0344
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0053 0.0128 0.02
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0033 0.0146
Trichomonas vaginalis set domain proteins, putative 0.0275 0.0872 0.3996
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0033 0.0033
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Leishmania major cathepsin L-like protease 0.0136 0.0406 0.0637
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0043 0.013
Onchocerca volvulus 0.0036 0.0071 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0071 0.032
Plasmodium vivax vivapain-2 0.0036 0.0071 0.1062
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0002 0.002
Schistosoma mansoni phd/f-box containing protein 0.0036 0.0071 0.0136
Schistosoma mansoni caspase-3 (C14 family) 0.002 0.002 0.0038
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0138 0.0412 0.0412
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.006
Echinococcus multilocularis lysine specific demethylase 6a 0.0036 0.0071 0.0071
Schistosoma mansoni mixed-lineage leukemia protein mll 0.014 0.042 0.0806
Trypanosoma cruzi metacaspase 5, putative 0.002 0.002 0.0031
Mycobacterium ulcerans oxidoreductase 0.0016 0.0004 0.0012
Schistosoma mansoni coup transcription factor 0.004 0.0087 0.0166
Brugia malayi nuclear hormone receptor 0.004 0.0087 0.026
Schistosoma mansoni cpg binding protein 0.0065 0.0171 0.0327
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0087 0.0087
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.006
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.003 0.0131
Trichomonas vaginalis glucosylceramidase, putative 0.0298 0.095 0.4353
Brugia malayi flavodoxin family protein 0.0138 0.0412 0.1238
Onchocerca volvulus 0.0065 0.0171 0.0512
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0138 0.0412 0.0647
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0071 0.032
Loa Loa (eye worm) hypothetical protein 0.034 0.109 0.3276
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0091 0.0589
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0118 0.0347 0.0666
Onchocerca volvulus 0.0036 0.0071 0.0213
Plasmodium vivax multidomain scavenger receptor, putative 0.0065 0.0168 0.2522
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.002 0.0086
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0196 0.0377
Leishmania major cytochrome p450-like protein 0.0015 0.0002 0.0003
Echinococcus granulosus cathepsin L cysteine proteinase 0.0036 0.0071 0.0136
Leishmania major hypothetical protein, conserved 0.0036 0.0071 0.0112
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0008 0.0015
Entamoeba histolytica P-glycoprotein-5 0.0024 0.0033 0.0152
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0033 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0087 0.0166
Mycobacterium ulcerans glutaminase 0.0316 0.1008 0.3023
Leishmania major NADH-dependent fumarate reductase-like protein 0.0016 0.0004 0.0006
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0118 0.0347 0.0347
Onchocerca volvulus 0.0088 0.0246 0.0739
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.027 0.0855 0.1341
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.0606 0.2778
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0033 0.0146
Mycobacterium leprae PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) 0.0095 0.0269 0.1747
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0033 0.0033
Echinococcus multilocularis cysteine protease 0.0036 0.0071 0.0071
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0043 0.013
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.002 0.0202
Echinococcus granulosus Polycystic kidney disease protein 0.0065 0.0168 0.0323
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0406 0.0637
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0298 0.095 0.2853
Entamoeba histolytica P-glycoprotein 5, putative 0.0024 0.0033 0.0152
Onchocerca volvulus 0.0129 0.0383 0.1149
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.006
Brugia malayi steroid hormone receptor 0.004 0.0087 0.026
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0023 0.0044
Leishmania major reductase, putative 0.0016 0.0004 0.0006
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0087 0.026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0023
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0124 0.0366 0.0575
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0088 0.0246 0.0739
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0087 0.0136
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0071 0.0325
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0002 0.0003
Loa Loa (eye worm) FAD binding domain-containing protein 0.0085 0.0236 0.0709
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0072 0.0138
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0033 0.0146
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0087 0.0166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0071 0.032
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0087 0.026
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0016 0.0004 0.0008
Toxoplasma gondii transporter, major facilitator family protein 0.0129 0.0383 0.3875
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0016 0.0004 0.0008
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0085 0.0236 0.0236
Chlamydia trachomatis sulfite reductase 0.0085 0.0236 0.1533
Loa Loa (eye worm) beta-lactamase 0.0042 0.0091 0.0273
Echinococcus granulosus lysine specific demethylase 5A 0.0138 0.0412 0.0791
Leishmania major NADH-dependent fumarate reductase, putative 0.0016 0.0004 0.0006
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0024 0.0033 0.0215
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Plasmodium vivax SET domain protein, putative 0.0036 0.0072 0.1076
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0071 0.0213
Loa Loa (eye worm) cysteine protease 0.0036 0.0071 0.0213
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0015 0.0002 0.0006
Trypanosoma cruzi metacaspase 5, putative 0.002 0.002 0.0031
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0013 0.006
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0071 0.0071
Trypanosoma cruzi reductase, putative 0.0016 0.0004 0.0006
Echinococcus multilocularis microtubule associated protein 2 0.1572 0.5213 0.5213
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0666 0.218 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0088 0.0246 0.0739
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0038 0.0078 0.0151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0087 0.026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0087 0.026
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0001 0.000000000061058
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0043 0.013
Loa Loa (eye worm) flavodoxin family protein 0.0053 0.0128 0.0384
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0071 0.0213
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0071 0.0071
Echinococcus multilocularis apoptotic protease activating factor 1 0.0048 0.0111 0.0111
Onchocerca volvulus 0.0129 0.0383 0.1149
Echinococcus granulosus nuclear factor of activated T cells 5 0.0085 0.0236 0.0453
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.0069
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0015 0.0046
Plasmodium falciparum acyl-CoA synthetase 0.002 0.002 0.013
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0216 0.0413
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0033 0.0063
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0033 0.0146
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0138 0.0412 0.0647
Leishmania major metacaspase, putative 0.002 0.002 0.0031
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0015 0.0002 0.0006
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0015 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.0406 0.0637
Echinococcus granulosus apoptotic protease activating factor 1 0.0048 0.0111 0.0213
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0091 0.0273
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0016 0.0049
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0091 0.0411
Schistosoma mansoni lipoxygenase 0.0137 0.0411 0.0788
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0087 0.0087
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0016 0.0004 0.0006
Trichomonas vaginalis glutaminase, putative 0.0316 0.1008 0.4621
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0015 0.0002 0.0006
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0016 0.0004 0.0006
Brugia malayi jmjC domain containing protein 0.0036 0.0071 0.0214

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) < 1 % Percent inhibitionagainst muscarinic acetylcholine receptor M4 from NG108-15 cell line ChEMBL. 2153827
Activity (binding) < 1 % Percent increase in [3H]-myo-inositol at muscarinic acetylcholine receptor M3 from SK-N-SH human neuroblastoma cells ChEMBL. 2153827
Affinity (binding) = 31 % Binding affinity at muscarinic acetylcholine receptor M4 from NG108-15 cell line in presence of [3H]-NMS ChEMBL. 2153827
Affinity (binding) = 39.2 % Percent binding affinity at muscarinic acetylcholine receptor M3 from SK-N-SH human neuroblastoma cells in presence of [3H]-NMS ChEMBL. 2153827

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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