Detailed information for compound 350347

Basic information

Technical information
  • TDR Targets ID: 350347
  • Name: 1-(3,5-dimethoxyphenyl)-3-(3-imidazol-1-ylpro pyl)thiourea
  • MW: 320.41 | Formula: C15H20N4O2S
  • H donors: 1 H acceptors: 1 LogP: 1.82 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1)OC)N/C(=N/CCCn1cncc1)/S
  • InChi: 1S/C15H20N4O2S/c1-20-13-8-12(9-14(10-13)21-2)18-15(22)17-4-3-6-19-7-5-16-11-19/h5,7-11H,3-4,6H2,1-2H3,(H2,17,18,22)
  • InChiKey: DSGYCCLPERQUIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3,5-dimethoxyphenyl)-3-[3-(1-imidazolyl)propyl]thiourea
  • 3-(3,5-dimethoxyphenyl)-1-(3-imidazol-1-ylpropyl)thiourea
  • 3-(3,5-dimethoxyphenyl)-1-[3-(1-imidazolyl)propyl]thiourea
  • 1-alkylimidazole thiourea deriv. 49

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutaminyl-peptide cyclotransferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus glutaminyl peptide cyclotransferase Get druggable targets OG5_129821 All targets in OG5_129821
Onchocerca volvulus Glutaminyl cyclase homolog Get druggable targets OG5_129821 All targets in OG5_129821
Brugia malayi Peptidase family M28 containing protein Get druggable targets OG5_129821 All targets in OG5_129821
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129821 All targets in OG5_129821
Schistosoma mansoni glutaminyl cyclase (M28 family) Get druggable targets OG5_129821 All targets in OG5_129821
Schistosoma japonicum ko:K00683 glutaminyl-peptide cyclotransferase [EC2.3.2.5], putative Get druggable targets OG5_129821 All targets in OG5_129821
Echinococcus multilocularis glutaminyl peptide cyclotransferase Get druggable targets OG5_129821 All targets in OG5_129821
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 glutaminyl-peptide cyclotransferase 361 aa 292 aa 21.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0045 0.0155 0.0268
Brugia malayi Pre-SET motif family protein 0.0239 0.1217 0.2207
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0229
Echinococcus multilocularis transcription factor btf3 0.004 0.0127 0.0127
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.0019 0.0056
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0133 0.0441
Schistosoma mansoni hypothetical protein 0.0945 0.5075 0.5881
Mycobacterium ulcerans GMP synthase 0.0038 0.0113 0.0388
Trichomonas vaginalis abcb9, putative 0.0024 0.004 0.0111
Brugia malayi hypothetical protein 0.0047 0.0166 0.0294
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0127 0.0127
Schistosoma mansoni hypothetical protein 0.0041 0.0133 0.0148
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0013 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0307 0.0567
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0078 0.0335 0.0383
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.004 0.004
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0552 0.1532
Schistosoma mansoni rab6-interacting 0.0045 0.0155 0.0174
Schistosoma mansoni multidrug resistance protein 0.0024 0.004 0.004
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.067 0.1205
Loa Loa (eye worm) glutaminase 2 0.0313 0.1617 0.293
Brugia malayi ecdysteroid receptor 0.004 0.0127 0.0223
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0198 0.0991 0.1149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0194 0.0219
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0133 0.0235
Loa Loa (eye worm) hypothetical protein 0.0128 0.0605 0.1089
Loa Loa (eye worm) hypothetical protein 0.0038 0.0113 0.0193
Onchocerca volvulus 0.0019 0.0013 0.0003
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0022 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.0087 0.0384 0.0686
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0022 0.0027 0.0027
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0139 0.0386
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.0968 0.2688
Mycobacterium ulcerans glutaminase 0.0313 0.1617 0.5881
Trypanosoma cruzi MFS transporter, putative 0.0128 0.0605 0.1132
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0056 0.0216 0.0245
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0127 0.0127
Onchocerca volvulus 0.0019 0.0013 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.0968 0.2688
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0019 0.0052
Schistosoma mansoni agrin 0.0087 0.0384 0.044
Echinococcus multilocularis dnaJ subfamily B 0.0945 0.5075 0.5075
Echinococcus multilocularis muscleblind protein 0.0345 0.1795 0.1795
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.0155 0.0155
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0675 0.36 1
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0307 0.0567
Plasmodium falciparum LCCL domain-containing protein 0.0045 0.0155 0.0576
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.1523 0.423
Echinococcus multilocularis apoptotic protease activating factor 1 0.0047 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0067 0.0276 0.049
Entamoeba histolytica hypothetical protein 0.004 0.0127 0.0318
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0056 0.018
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0117 0.0548 0.063
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0027 0.0074
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0087 0.0384 0.3529
Echinococcus multilocularis mitogen activated protein kinase 3 0.0118 0.0552 0.0552
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0304 0.0347
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0239 0.1217 0.2202
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0027 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0013 0.0035
Mycobacterium leprae Probable lipase LipE 0.0041 0.0133 0.0318
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0084 0.0368 0.0368
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0019 0.0052
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.004 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.0968 0.2688
Entamoeba histolytica P-glycoprotein-1 0.0024 0.004 0.0076
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0027 0.0027
Giardia lamblia Fructose-bisphosphate aldolase 0.0675 0.36 1
Echinococcus granulosus cpg binding protein 0.007 0.0291 0.0338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0307 0.0567
Leishmania major cathepsin L-like protease 0.0019 0.0013 0.0011
Entamoeba histolytica hypothetical protein 0.0041 0.0133 0.0335
Brugia malayi Cathepsin L-like precursor 0.0019 0.0013 0.0016
Schistosoma mansoni lipoxygenase 0.0198 0.0991 0.1143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0127 0.0217
Echinococcus multilocularis geminin 0.0194 0.0968 0.0968
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0304 0.054
Trichomonas vaginalis hypothetical protein 0.0212 0.1065 0.2959
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.002 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0229
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0023 0.0023
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0127 0.0147
Schistosoma mansoni cpg binding protein 0.007 0.0291 0.0332
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.002 0.0019 0.0016
Plasmodium vivax SET domain protein, putative 0.0036 0.0103 0.0854
Mycobacterium tuberculosis Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) 0.0094 0.0422 0.1496
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0026 0.004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0013 0.0035
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0133 0.0318
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0066 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0127 0.0223
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0013 0.0011
Mycobacterium tuberculosis Conserved protein 0.0041 0.0133 0.0441
Loa Loa (eye worm) hypothetical protein 0.0087 0.0384 0.0686
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.0155 0.0155
Onchocerca volvulus 0.0036 0.0103 0.0167
Onchocerca volvulus 0.0087 0.0384 0.0679
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0133 0.0238
Brugia malayi SPARC precursor 0.0087 0.0384 0.0692
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.004 0.0127 0.0127
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0127 0.0141
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0139 0.0665 0.1245
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0212 0.1065 0.4167
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0022 0.0027 0.0072
Brugia malayi hypothetical protein 0.027 0.1387 0.2515
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0056 0.018
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0005 0.0005
Echinococcus multilocularis pol protein 0.1846 1 1
Trichomonas vaginalis ABC transporter, putative 0.0024 0.004 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0106 0.018
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.047 0.2477 1
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0013 0.0009
Loa Loa (eye worm) agrin synaptic family protein 0.0087 0.0384 0.0686
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.004 0.004
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0067 0.0272 0.0502
Schistosoma mansoni smdr2 0.0024 0.004 0.004
Toxoplasma gondii NAC domain-containing protein 0.004 0.0127 0.1082
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0552 0.1532
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0675 0.36 1
Plasmodium falciparum metacaspase-like protein 0.002 0.0019 0.0024
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0133 0.0441
Trichomonas vaginalis ABC transporter, putative 0.0024 0.004 0.0111
Loa Loa (eye worm) hypothetical protein 0.004 0.0127 0.0217
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0139 0.0386
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0088 0.0102
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0127 0.0141
Plasmodium vivax metacaspase 1, putative 0.002 0.0019 0.0056
Echinococcus granulosus dnaJ subfamily B 0.0945 0.5075 0.5884
Entamoeba histolytica transcription factor BTF3, putative 0.004 0.0127 0.0318
Onchocerca volvulus Putative organic anion transporter 0.0128 0.0605 0.1082
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.0094 0.0422 0.1659
Brugia malayi beta-lactamase 0.0041 0.0133 0.0235
Onchocerca volvulus 0.0041 0.0133 0.0222
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0022 0.0027 0.0051
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.006
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.033 0.1712 0.6224
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0133 0.0441
Brugia malayi nuclear receptor NHR-67 0.0019 0.0011 0.0013
Leishmania major hypothetical protein, conserved 0.0022 0.0027 0.0037
Echinococcus granulosus cathepsin l1 0.0019 0.0013 0.0015
Echinococcus multilocularis agrin 0.0087 0.0384 0.0384
Onchocerca volvulus 0.0272 0.1398 0.2525
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0139 0.0249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0307 0.0567
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0056 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1025 0.2846
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.004 0.0046
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0019 0.0052
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0011 0.0013
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.047 0.2477 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.0605 0.1089
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0118 0.0552 0.103
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0127 0.0223
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.004 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0127 0.0127
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0133 0.0238
Schistosoma mansoni caspase-7 (C14 family) 0.002 0.0019 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0307 0.0567
Trichomonas vaginalis glutaminase, putative 0.0313 0.1617 0.4493
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.0094 0.0422 0.1171
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0106 0.018
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0552 0.1532
Trichomonas vaginalis taga, putative 0.0024 0.004 0.0111
Onchocerca volvulus 0.0022 0.0027 0.0029
Echinococcus granulosus RUN 0.0045 0.0155 0.0179
Brugia malayi sodium-independent organic anion transporter family protein 0.0128 0.0605 0.1094
Brugia malayi Inositol-1 0.0042 0.0139 0.0246
Leishmania major NAD synthase, putative 0.0094 0.0422 0.0784
Echinococcus multilocularis RUN 0.0045 0.0155 0.0155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0307 0.0567
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0056 0.018
Plasmodium vivax JmjC domain containing protein 0.0036 0.0106 0.0888
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.0094 0.0422 0.3885
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0307 0.0567
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0212 0.1065 0.3864
Treponema pallidum fructose-bisphosphate aldolase 0.0675 0.36 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0194 0.0219
Brugia malayi conserved hypotetical protein 0.0019 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0078 0.0335 0.0597
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0103 0.0113
Schistosoma mansoni multidrug resistance protein 0.0024 0.004 0.004
Brugia malayi sodium-independent organic anion transporter family protein 0.0128 0.0605 0.1094
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0229
Schistosoma mansoni phosphatidylserine receptor 0.0036 0.0106 0.0117
Schistosoma mansoni nuclear receptor 0.0019 0.0011 0.0007
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.1523 0.423
Onchocerca volvulus 0.0066 0.0271 0.0473
Schistosoma mansoni coup transcription factor 0.004 0.0127 0.0141
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0127 0.0141
Brugia malayi hypothetical protein 0.0021 0.0023 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0127 0.0223
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0128 0.0605 0.0605
Schistosoma mansoni nuclear hormone receptor 0.004 0.0127 0.0141
Mycobacterium tuberculosis Conserved hypothetical protein 0.0519 0.2746 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0013 0.001
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.047 0.2477 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0087 0.0384 0.3529
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.009
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0021
Trypanosoma brucei transcription factor BTF3, putative 0.004 0.0127 0.0226
Mycobacterium tuberculosis Conserved protein 0.0022 0.0027 0.0051
Loa Loa (eye worm) hypothetical protein 0.0087 0.0384 0.0686
Echinococcus multilocularis muscleblind protein 1 0.0345 0.1795 0.1795
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0127 0.0217
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0011 0.0013
Echinococcus granulosus lysine specific demethylase 5A 0.014 0.0672 0.0779
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0675 0.36 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0019 0.0052
Loa Loa (eye worm) hypothetical protein 0.1023 0.5503 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.0605 0.1089
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0127 0.0141
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0127 0.0147
Trichomonas vaginalis esterase, putative 0.0041 0.0133 0.037
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0066 0.0111
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0117 0.0548 0.0548
Brugia malayi glutaminase DH11.1 0.0313 0.1617 0.2934
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0036 0.0106 0.0187
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0133 0.0154
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0011 0.0011
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.004 0.004
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0106 0.018
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0127 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0118 0.0552 0.103
Schistosoma mansoni hypothetical protein 0.0113 0.0523 0.0601
Loa Loa (eye worm) hypothetical protein 0.0128 0.0605 0.1089
Brugia malayi jmjC domain containing protein 0.0136 0.0651 0.1177
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0985 0.5295 1
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0019 0.0058
Loa Loa (eye worm) hypothetical protein 0.004 0.0127 0.0217
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0011 0.0013
Brugia malayi steroid hormone receptor 0.004 0.0127 0.0223
Echinococcus multilocularis caspase 2 0.0067 0.0276 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0307 0.0567
Brugia malayi Melibiase family protein 0.0078 0.0335 0.0603
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0194 0.0346
Toxoplasma gondii ABC1 family protein 0.0041 0.0133 0.1144
Schistosoma mansoni jumonji domain containing protein 0.0036 0.0106 0.0117
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0087 0.0384 0.3529
Entamoeba histolytica P-glycoprotein-2, putative 0.0024 0.004 0.0076
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0466 0.2457 0.4634
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0118 0.0552 0.103
Schistosoma mansoni zinc finger protein 0.0019 0.0011 0.0007
Trypanosoma brucei metacaspase MCA2 0.002 0.0019 0.0022
Echinococcus granulosus Solute carrier organic anion transporter family 0.0128 0.0605 0.0702
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0106 0.0187
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0133 0.037
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0011 0.0013
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.0019 0.0056
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0087 0.0384 0.3529
Leishmania major hypothetical protein, conserved 0.0036 0.0106 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0127 0.0352
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0127 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.003
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0005 0.0005
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0136 0.0654 0.0759
Echinococcus multilocularis mitogen activated protein kinase 0.0118 0.0552 0.0552
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0127 0.0147
Schistosoma mansoni cpg binding protein 0.0066 0.0271 0.0308
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0011 0.0007
Echinococcus multilocularis pol protein 0.1846 1 1
Echinococcus granulosus tar DNA binding protein 0.0072 0.0304 0.0353
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0304 0.0347
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0127 0.0147
Schistosoma mansoni inositol monophosphatase 0.0042 0.0139 0.0155
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0056 0.0159
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0011 0.0013
Brugia malayi hypothetical protein 0.0021 0.0023 0.0036
Brugia malayi Cytochrome P450 family protein 0.003 0.0072 0.0123
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.004 0.0111
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.004 0.0111
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.003
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0038 0.0113 0.0131
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0036 0.0106 0.0888
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0024 0.004 0.0258
Onchocerca volvulus 0.0041 0.0133 0.0222
Mycobacterium ulcerans beta-lactamase 0.0041 0.0133 0.046
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0036 0.0106 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0127 0.0217
Schistosoma mansoni caspase-3 (C14 family) 0.002 0.0019 0.0016
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0136 0.0654 0.0654
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0127 0.0147
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0013 0.001
Mycobacterium ulcerans hypothetical protein 0.0022 0.0027 0.0072
Echinococcus granulosus caspase 2 0.0067 0.0276 0.032
Loa Loa (eye worm) fibroinase 0.0019 0.0013 0.001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0133 0.0149
Loa Loa (eye worm) hypothetical protein 0.004 0.0127 0.0217
Brugia malayi CXXC zinc finger family protein 0.0066 0.0271 0.0486
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0127 0.0147
Brugia malayi hypothetical protein 0.0019 0.001 0.0011
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0118 0.0552 0.0991
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0127 0.0217
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0194 0.034
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0127 0.0226
Brugia malayi ABC transporter family protein 0.0024 0.004 0.0066
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.047 0.2477 0.9019
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0103 0.0119
Trypanosoma brucei Metacaspase-4 0.002 0.0019 0.0022
Brugia malayi TAR-binding protein 0.0072 0.0304 0.0546
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0019 0.0052
Entamoeba histolytica P-glycoprotein-2 0.0024 0.004 0.0076
Echinococcus granulosus caspase 0.002 0.0019 0.0022
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.0019 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0307 0.0567
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0066 0.0111
Onchocerca volvulus 0.004 0.0127 0.021
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0019 0.0022
Brugia malayi Cathepsin L-like precursor 0.0019 0.0013 0.0016
Trypanosoma cruzi glutaminyl cyclase, putative 0.0022 0.0027 0.0037
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0127 0.0127
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0011 0.0007
Entamoeba histolytica NAD synthetase, putative 0.0094 0.0422 0.114
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0022 0.0027 0.0031
Brugia malayi tailless protein 0.0019 0.0011 0.0013
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0127 0.0141
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0229
Echinococcus multilocularis Protein lozenge 0.0128 0.061 0.061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Brugia malayi jmjC domain containing protein 0.0036 0.0106 0.0186
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0023 0.003
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.004 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.009
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.004 0.0111
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0675 0.36 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0985 0.5295 1
Mycobacterium tuberculosis Conserved protein 0.0041 0.0133 0.0441
Plasmodium falciparum basic transcription factor 3b, putative 0.004 0.0127 0.0462
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0013 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0056 0.0096
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.004 0.0111
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0066 0.0215
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0127 0.021
Onchocerca volvulus Putative organic anion transporter 0.0128 0.0605 0.1082
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0139 0.0352
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0013 0.0003
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0011 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0133 0.0149
Brugia malayi Doublecortin family protein 0.0045 0.0155 0.0274
Entamoeba histolytica hypothetical protein 0.0041 0.0133 0.0335
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0307 0.0567
Brugia malayi nicalin 0.0022 0.0027 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0056 0.0096
Brugia malayi Pre-SET motif family protein 0.0036 0.0103 0.018
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0118 0.0552 0.103
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0013 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0019 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0127 0.0352
Brugia malayi multidrug resistance protein 3 0.0024 0.004 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0466 0.2457 0.4634
Schistosoma mansoni hypothetical protein 0.0047 0.0166 0.0186
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0118 0.0552 0.103
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0212 0.1065 0.4256
Echinococcus granulosus geminin 0.0194 0.0968 0.1122
Entamoeba histolytica hypothetical protein 0.0041 0.0133 0.0335
Schistosoma mansoni polycystin 1-related 0.0045 0.0155 0.0174
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0057
Echinococcus multilocularis caspase 0.002 0.0019 0.0019
Brugia malayi ecdysone receptor 0.0019 0.0011 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0127 0.0223
Brugia malayi jmjC domain containing protein 0.0036 0.0106 0.0186
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0056 0.018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0675 0.36 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0139 0.0249
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0056 0.0093
Echinococcus multilocularis cysteine protease 0.0019 0.0013 0.0013
Echinococcus multilocularis phd:f box containing protein 0.0036 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0229
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0013 0.0013
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0212 0.1065 0.3961
Mycobacterium ulcerans hypothetical protein 0.0041 0.0133 0.046
Trichomonas vaginalis abcb9, putative 0.0024 0.004 0.0111
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0056 0.0093
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0023 0.0036
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0038 0.0113 0.0113
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0038 0.0113 0.0408
Brugia malayi Cytochrome P450 family protein 0.0018 0.0007 0.0006
Entamoeba histolytica P-glycoprotein 5, putative 0.0024 0.004 0.0076
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0117 0.0548 0.0636
Onchocerca volvulus 0.0019 0.0013 0.0003
Brugia malayi secreted modular calcium-binding protein 1 0.0087 0.0384 0.0692
Brugia malayi sodium-independent organic anion transporter family protein 0.0128 0.0605 0.1094
Plasmodium vivax hypothetical protein, conserved 0.002 0.0019 0.0056
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0011 0.0007
Schistosoma mansoni Fxna peptidase (M28 family) 0.0022 0.0027 0.0025
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0127 0.021
Trypanosoma cruzi metacaspase 5, putative 0.002 0.0019 0.0022
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0103 0.0103
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0552 0.0634
Trypanosoma brucei metacaspase 0.002 0.0019 0.0022
Echinococcus granulosus caspase 8 0.002 0.0019 0.0022
Schistosoma mansoni transcription factor btf3 0.004 0.0127 0.0141
Brugia malayi Cell death protein 3 precursor 0.0067 0.0276 0.0496
Loa Loa (eye worm) hypothetical protein 0.004 0.0127 0.0217
Echinococcus granulosus follistatin 0.0087 0.0384 0.0445
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0024 0.004 0.006
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.033 0.1712 0.6837
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.004 0.0111
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0019 0.0052
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0304 0.054
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.004 0.004
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.0968 0.2688
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0011 0.0011
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0136 0.0654 0.0753
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0115 0.0373
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0023 0.0021
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0024 0.004 0.0099
Onchocerca volvulus 0.0045 0.0155 0.0261
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.004 0.0111
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0011 0.0007
Echinococcus multilocularis microtubule associated protein 2 0.1594 0.8625 0.8625
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.0968 0.2688
Echinococcus multilocularis caspase 8 0.002 0.0019 0.0019
Echinococcus multilocularis pol protein 0.1846 1 1
Leishmania major hypothetical protein, conserved 0.0029 0.0066 0.0111
Loa Loa (eye worm) jmjC domain-containing protein 0.014 0.0672 0.1209
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0466 0.2457 0.4634
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0022 0.0027 0.0025
Echinococcus multilocularis cpg binding protein 0.007 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.004 0.0127 0.0217
Plasmodium falciparum multidrug resistance protein 1 0.0024 0.004 0.011
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0038 0.0038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0127 0.0223
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0013 0.0011
Schistosoma mansoni jumonji domain containing protein 0.0136 0.0651 0.0749
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.004 0.0111
Trypanosoma cruzi metacaspase, putative 0.002 0.0019 0.0022
Leishmania major cathepsin L-like protease 0.0073 0.0307 0.0567
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0127 0.0223
Echinococcus multilocularis cysteine protease 0.0019 0.0013 0.0013
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.004 0.0111
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0133 0.0441
Brugia malayi hypothetical protein 0.0045 0.0155 0.0274
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0133 0.046
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0078 0.0335 0.0931
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0133 0.037
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0212 0.1065 0.3851
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0011 0.0007
Entamoeba histolytica hypothetical protein 0.0041 0.0133 0.0335
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0307 0.0567
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0133 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0027 0.0074
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0263 0.1346 0.488
Leishmania major basic transcription factor 3a, putative 0.004 0.0127 0.0226
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0023 0.0021
Plasmodium vivax multidomain scavenger receptor, putative 0.0045 0.0155 0.1348
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0271 0.048
Brugia malayi jmjC domain containing protein 0.014 0.0672 0.1214
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0139 0.0665 0.1245
Onchocerca volvulus 0.0047 0.0166 0.0281
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0127 0.0217
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0056 0.018
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0212 0.1065 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0169 0.0831 0.1558
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0307 0.0567
Brugia malayi hypothetical protein 0.1023 0.5503 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0127 0.0217
Plasmodium falciparum JmjC domain-containing protein, putative 0.0036 0.0106 0.0379
Trichomonas vaginalis set domain proteins, putative 0.0272 0.1397 0.3881
Echinococcus granulosus Polycystic kidney disease protein 0.0045 0.0155 0.0179
Onchocerca volvulus 0.0041 0.0133 0.0222
Loa Loa (eye worm) hypothetical protein 0.1023 0.5503 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0056 0.018
Brugia malayi hypothetical protein 0.0041 0.0133 0.0235
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0056 0.018
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0005 0.0006
Brugia malayi FXNA 0.0022 0.0027 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0021
Schistosoma mansoni microtubule-associated protein tau 0.1594 0.8625 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0087 0.0384 0.0692
Schistosoma mansoni phd/f-box containing protein 0.0036 0.0106 0.0117
Toxoplasma gondii protease inhibitor PI2 0.0087 0.0384 0.3529
Schistosoma mansoni hypothetical protein 0.0194 0.0968 0.1117
Loa Loa (eye worm) DR-78 0.0019 0.0011 0.0007
Brugia malayi nuclear receptor NHR-88 0.004 0.0127 0.0223
Leishmania major cathepsin L-like protease 0.0019 0.0013 0.0011
Onchocerca volvulus Glutaminyl cyclase homolog 0.0136 0.0654 0.1171
Onchocerca volvulus 0.0128 0.0605 0.1082
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0106 0.0187
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0078 0.0335 0.0383
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0136 0.0651 0.0755
Echinococcus multilocularis Polycystic kidney disease protein 0.0045 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0021
Loa Loa (eye worm) cysteine protease 0.0019 0.0013 0.001
Entamoeba histolytica P-glycoprotein-2 0.0024 0.004 0.0076
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0139 0.0249
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0117 0.0548 0.063
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.047 0.2477 0.6468
Leishmania major cathepsin L-like protease 0.0073 0.0307 0.0567
Loa Loa (eye worm) hypothetical protein 0.0045 0.0155 0.0268
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0013 0.0016
Onchocerca volvulus Fxna peptidase homolog 0.0022 0.0027 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.1523 0.423
Giardia lamblia Kinase, CMGC MAPK 0.0118 0.0552 0.0409
Onchocerca volvulus 0.0055 0.021 0.0361
Echinococcus granulosus jumonji domain containing 1A 0.0036 0.0106 0.0123
Schistosoma mansoni nicalin (M28 family) 0.0022 0.0027 0.0025
Onchocerca volvulus Putative organic anion transporter 0.0128 0.0605 0.1082
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0139 0.0386
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.004 0.0111
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0133 0.0148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0194 0.0194
Onchocerca volvulus 0.0019 0.0013 0.0003
Schistosoma mansoni jumonji/arid domain-containing protein 0.014 0.0672 0.0773
Loa Loa (eye worm) hypothetical protein 0.0036 0.0106 0.018
Echinococcus multilocularis jumonji domain containing 1A 0.0036 0.0106 0.0106
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0013 0.0013
Leishmania major metacaspase, putative 0.002 0.0019 0.0022
Mycobacterium leprae PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) 0.0094 0.0422 0.1509
Brugia malayi nuclear hormone receptor 0.0019 0.0011 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0013 0.0035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0013 0.0035
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.004 0.0046
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0056 0.0121
Trypanosoma brucei metacaspase 5, putative 0.002 0.0019 0.0022
Toxoplasma gondii histone lysine methyltransferase SET1 0.0127 0.0602 0.5601
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0675 0.36 1
Echinococcus granulosus phd:f box containing protein 0.0036 0.0106 0.0123
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0118 0.0552 0.103
Brugia malayi beta-lactamase family protein 0.0041 0.0133 0.0235
Loa Loa (eye worm) hypothetical protein 0.0029 0.0066 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0127 0.0223
Loa Loa (eye worm) beta-lactamase 0.0041 0.0133 0.0229
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0019 0.0043
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0019 0.0052
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0011 0.0013
Echinococcus granulosus microtubule associated protein 2 0.1594 0.8625 1
Toxoplasma gondii melibiase subfamily protein 0.0117 0.0548 0.5091
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.004 0.0046
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0127 0.0127
Loa Loa (eye worm) runx1 0.0128 0.061 0.1097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.003
Leishmania major glutaminyl cyclase, putative 0.0022 0.0027 0.0037
Schistosoma mansoni lipoxygenase 0.0117 0.0547 0.0629
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.0968 0.2688
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0133 0.046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0153 0.0743 0.0861
Loa Loa (eye worm) hypothetical protein 0.0345 0.1795 0.3253
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0024 0.0038 0.0044
Brugia malayi nuclear receptor RXR 0.0019 0.0011 0.0013
Leishmania major cathepsin L-like protease 0.0073 0.0307 0.0567
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0133 0.037
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.004 0.0111
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0115 0.0242
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0133 0.1144
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.004 0.0127 0.0147
Trypanosoma cruzi transcription factor btf3, putative 0.004 0.0127 0.0226
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.003
Trichomonas vaginalis ABC transporter, putative 0.0024 0.004 0.0111
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0022 0.0027 0.0074
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0304 0.0546
Onchocerca volvulus 0.0019 0.0013 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0013 0.0035
Schistosoma mansoni cpg binding protein 0.007 0.0291 0.0332
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.021 0.0374
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.0094 0.0422 0.3885
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0013 0.0035
Onchocerca volvulus Fxna peptidase homolog 0.0022 0.0027 0.0029
Trypanosoma brucei metacaspase MCA3 0.002 0.0019 0.0022
Mycobacterium ulcerans NAD synthetase 0.0094 0.0422 0.1514
Brugia malayi hypothetical protein 0.0045 0.0155 0.0274
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0087 0.0384 0.0686
Loa Loa (eye worm) hypothetical protein 0.0345 0.1795 0.3253
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0139 0.0249
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0011 0.0007
Brugia malayi GMP synthase 0.0038 0.0113 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0127 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0304 0.0347
Loa Loa (eye worm) ICD-1 protein 0.004 0.0127 0.0218
Echinococcus multilocularis expressed protein 0.0087 0.0384 0.0384
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.004 0.0111
Loa Loa (eye worm) hypothetical protein 0.0128 0.0605 0.1089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0194 0.0225
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0127 0.0223
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0024 0.004 0.0062
Schistosoma mansoni hypothetical protein 0.0045 0.0155 0.0174
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.004 0.0111
Echinococcus granulosus agrin 0.0087 0.0384 0.0445
Leishmania major p-glycoprotein 0.0024 0.004 0.0062
Brugia malayi hypothetical protein 0.0128 0.0605 0.1094
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0019 0.0052
Loa Loa (eye worm) glutaminase 0.0313 0.1617 0.293
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0013 0.0003
Brugia malayi jmjC domain containing protein 0.0036 0.0106 0.0186
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0066 0.0503
Echinococcus granulosus JmjC domain containing protein 4 0.0036 0.0106 0.0123
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.067 0.1205
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Onchocerca volvulus Cell death protein 3 homolog 0.0067 0.0276 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0019 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0072 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0013 0.0035
Mycobacterium tuberculosis Conserved protein 0.0041 0.0133 0.0441
Trypanosoma cruzi metacaspase, putative 0.002 0.0019 0.0022
Echinococcus granulosus FTZ F1 alpha 0.004 0.0127 0.0147
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0023 0.0027
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.004 0.0111
Loa Loa (eye worm) hypothetical protein 0.004 0.0127 0.0217
Onchocerca volvulus Glucosylceramidase homolog 0.0194 0.0968 0.1742
Brugia malayi Cytochrome P450 family protein 0.0018 0.0007 0.0006
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0022 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0127 0.0223
Brugia malayi leucyl aminopeptidase 0.0022 0.0027 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0194 0.0968 0.2688
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0011 0.0013
Echinococcus multilocularis lysine specific demethylase 5A 0.0136 0.0651 0.0651
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0127 0.0141
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.047 0.2477 0.9021
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0552 0.1532
Plasmodium vivax basic transcription factor 3b, putative 0.004 0.0127 0.1082
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.004 0.004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0056 0.0121
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0136 0.0651 0.0651
Brugia malayi nuclear hormone receptor 0.004 0.0127 0.0223
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0128 0.0605 0.0702
Trichomonas vaginalis ABC transporter, putative 0.0024 0.004 0.0111
Schistosoma mansoni nuclear receptor 0.0019 0.0011 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0056 0.0093
Schistosoma mansoni caspase-7 (C14 family) 0.0067 0.0276 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0022 0.0027 0.0027
Echinococcus granulosus transcription factor btf3 0.004 0.0127 0.0147
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.004 0.004
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.0155 0.0179
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0103 0.0113
Onchocerca volvulus 0.0024 0.004 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0127 0.0223
Leishmania major cathepsin L-like protease 0.0019 0.0013 0.0011
Brugia malayi Cathepsin L-like precursor 0.0019 0.0013 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0304 0.0347
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0066 0.0503
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.004 0.0111
Brugia malayi nuclear receptor NHR-88 0.0019 0.0011 0.0013
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.0155 0.0179
Echinococcus granulosus mitogen activated protein kinase 3 0.0118 0.0552 0.064
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0013 0.0009
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0304 0.0304
Leishmania major mitochondrial DNA polymerase beta 0.0985 0.5295 1
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0139 0.0161
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0118 0.0552 0.5121
Trypanosoma cruzi NAD+ synthase, putative 0.0094 0.0422 0.0784
Loa Loa (eye worm) hypothetical protein 0.0047 0.0166 0.0289
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0036 0.0106 0.0888
Brugia malayi hypothetical protein 0.0128 0.0605 0.1094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0036
Echinococcus granulosus survival motor neuron protein 1 0.027 0.1387 0.1608
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0198 0.0991 0.0991
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0013 0.0013
Brugia malayi Cathepsin L-like precursor 0.0019 0.0013 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0665 0.1245
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0011 0.0013
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0038 0.0113 0.0201
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0019 0.0052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Brugia malayi Muscleblind-like protein 0.0345 0.1795 0.3257
Brugia malayi Cathepsin L-like precursor 0.0019 0.0013 0.0016
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0194 0.0225
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0011 0.0013
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Schistosoma mansoni survival motor neuron protein 0.0055 0.021 0.0237
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0022 0.0027 0.0025
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0133 0.0133
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0117 0.0548 0.0548
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0106 0.018
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.004 0.0111
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0133 0.0441
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.002 0.0019 0.0022
Loa Loa (eye worm) multidrug resistance protein 3 0.0024 0.004 0.006
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0027 0.0037
Schistosoma mansoni glutaminase 0.0313 0.1617 0.187
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0103 0.0113
Schistosoma mansoni organic anion transporter 0.0128 0.0605 0.0697
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0127 0.0217
Brugia malayi beta-lactamase family protein 0.0041 0.0133 0.0235
Schistosoma mansoni thyroid hormone receptor 0.004 0.0127 0.0141
Onchocerca volvulus 0.0128 0.0605 0.1082
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.004 0.0046
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0174
Toxoplasma gondii peptidase, M28 family protein 0.0022 0.0027 0.0134
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0056 0.0159
Plasmodium falciparum metacaspase 1 0.002 0.0019 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.004 0.0111
Onchocerca volvulus Fxna peptidase homolog 0.0022 0.0027 0.0029
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.004 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0127 0.0223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0295 0.1523 0.2762
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0128 0.0605 0.0605
Echinococcus multilocularis JmjC domain containing protein 4 0.0036 0.0106 0.0106
Onchocerca volvulus 0.0128 0.0605 0.1082
Onchocerca volvulus 0.0128 0.0605 0.1082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0127 0.0127
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0066 0.0215
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0128 0.0605 0.1089
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0304 0.0347
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0011 0.0013
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0118 0.0552 0.103
Loa Loa (eye worm) hypothetical protein 0.0022 0.0027 0.0036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0675 0.36 1
Echinococcus granulosus mitogen activated protein kinase 0.0118 0.0552 0.064
Onchocerca volvulus 0.1023 0.5503 1
Mycobacterium ulcerans hypothetical protein 0.0027 0.0056 0.018
Schistosoma mansoni thyroid hormone receptor 0.004 0.0127 0.0141
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0024 0.004 0.0086
Plasmodium vivax multidrug resistance protein 1, putative 0.0024 0.004 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0019 0.0052
Brugia malayi nuclear receptor RXR 0.0021 0.0023 0.0036
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0038 0.0113 0.0956
Echinococcus granulosus lysine specific demethylase 6a 0.0036 0.0106 0.0123
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0011 0.0007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0133 0.0441
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0019 0.0052
Schistosoma mansoni GMP synthetase 0.0038 0.0113 0.0126
Trypanosoma cruzi metacaspase 5, putative 0.002 0.0019 0.0022
Entamoeba histolytica P-glycoprotein-5 0.0024 0.004 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0194 0.0219
Schistosoma mansoni loxhd1 0.0045 0.0155 0.0174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0675 0.36 1
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0019 0.0025
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0087 0.0384 0.0692
Brugia malayi beta-NAC-like protein 0.004 0.0127 0.0223
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0132 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.009
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0013 0.0015
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0127 0.021
Schistosoma mansoni hypothetical protein 0.0055 0.021 0.0237
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0139 0.0482
Echinococcus granulosus nuclear factor of activated T cells 5 0.0084 0.0368 0.0427
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0194 0.0194
Brugia malayi MAP kinase sur-1 0.0118 0.0552 0.0996
Trypanosoma cruzi metacaspase, putative 0.002 0.0019 0.0022
Loa Loa (eye worm) hypothetical protein 0.0087 0.0384 0.0686
Schistosoma mansoni multidrug resistance protein 0.0024 0.004 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.1523 0.423
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0133 0.037
Schistosoma mansoni lozenge 0.0128 0.061 0.0702
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.1523 0.423
Loa Loa (eye worm) inositol-1 0.0042 0.0139 0.024
Loa Loa (eye worm) ctsf protein 0.0019 0.0013 0.001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0019 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0019 0.0052
Brugia malayi prostaglandin transporter 0.0128 0.0605 0.1094
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.001
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.004 0.0258
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0127 0.0141
Loa Loa (eye worm) RNA binding protein 0.0072 0.0304 0.054
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0094 0.0422 0.0483
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0127 0.0127
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.002 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Loa Loa (eye worm) leucyl aminopeptidase 0.0022 0.0027 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0127 0.0217
Mycobacterium ulcerans lipase LipD 0.0041 0.0133 0.046
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0005 0.0006
Trypanosoma cruzi NAD+ synthase, putative 0.0094 0.0422 0.0784
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0011 0.0011
Trypanosoma brucei RNA helicase, putative 0.0113 0.0523 0.0976
Trypanosoma brucei protein kinase, putative 0.0118 0.0552 0.103
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0127 0.0141
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0117 0.0548 0.063
Echinococcus multilocularis survival motor neuron protein 1 0.027 0.1387 0.1387
Trypanosoma cruzi metacaspase, putative 0.002 0.0019 0.0022
Mycobacterium ulcerans hypothetical protein 0.0519 0.2746 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0127 0.0217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0013 0.0035
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0985 0.5295 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0675 0.36 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0139 0.0665 0.1245
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0021
Schistosoma mansoni organic anion transporter 0.0128 0.0605 0.0697
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0117 0.0548 0.063
Brugia malayi hypothetical protein 0.0019 0.0011 0.0013
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0056 0.0096
Onchocerca volvulus 0.0019 0.0013 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0127 0.0223
Loa Loa (eye worm) hypothetical protein 0.0041 0.0133 0.0229
Brugia malayi jmjC domain containing protein 0.0036 0.0106 0.0186
Trypanosoma cruzi cruzipain precursor, putative 0.0073 0.0307 0.0567
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0133 0.0441
Onchocerca volvulus 0.0027 0.0056 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0307 0.0567
Echinococcus granulosus apoptotic protease activating factor 1 0.0047 0.0166 0.0192
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.0007
Leishmania major hypothetical protein, conserved 0.0041 0.0133 0.0238
Toxoplasma gondii hypothetical protein 0.0159 0.0777 0.7261
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0222 0.0406
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0212 0.1065 1
Schistosoma mansoni follistatin 0.0087 0.0384 0.044
Trichomonas vaginalis glucosylceramidase, putative 0.0295 0.1523 0.423
Echinococcus multilocularis lysine specific demethylase 6a 0.0036 0.0106 0.0106
Entamoeba histolytica P-glyco protein 6, putative 0.0024 0.004 0.0076
Onchocerca volvulus 0.0045 0.0155 0.0261
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.004 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0127 0.0217
Brugia malayi MH2 domain containing protein 0.0139 0.067 0.1211
Plasmodium vivax GMP synthetase, putative 0.0038 0.0113 0.0956
Brugia malayi hypothetical protein 0.0029 0.0066 0.0113
Echinococcus granulosus muscleblind protein 0.0345 0.1795 0.2081
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.004 0.0111
Brugia malayi Peptidase family M28 containing protein 0.0136 0.0654 0.1183
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0133 0.0133
Brugia malayi RNA binding protein 0.0072 0.0304 0.0546
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0133 0.0238
Loa Loa (eye worm) hypothetical protein 0.0136 0.0654 0.1178
Loa Loa (eye worm) hypothetical protein 0.0128 0.0605 0.1089
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0127 0.0223
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.004 0.0111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0013 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0675 0.36 1
Schistosoma mansoni hypothetical protein 0.0194 0.0968 0.1117
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0087 0.0384 0.0692
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.004 0.0111
Loa Loa (eye worm) doublecortin family protein 0.0045 0.0155 0.0268
Leishmania major cathepsin L-like protease 0.0019 0.0013 0.0011
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0139 0.12
Echinococcus multilocularis follistatin 0.0087 0.0384 0.0384
Trypanosoma brucei glutaminyl cyclase, putative 0.0022 0.0027 0.0037
Trypanosoma cruzi glutaminyl cyclase, putative 0.0022 0.0027 0.0037
Brugia malayi hypothetical protein 0.0019 0.0011 0.0013
Toxoplasma gondii transporter, major facilitator family protein 0.0128 0.0605 0.5632
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0021
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.004 0.0046
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0011 0.0007
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.004 0.0046
Trichomonas vaginalis abcb9, putative 0.0024 0.004 0.0111
Loa Loa (eye worm) hypothetical protein 0.0024 0.004 0.006
Toxoplasma gondii hypothetical protein 0.0022 0.0027 0.0134
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0023 0.0036
Onchocerca volvulus 0.0128 0.0605 0.1082
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0013 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0127 0.0352
Onchocerca volvulus 0.0019 0.0013 0.0003
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0295 0.1523 0.2758
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.047 0.2477 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.0605 0.1089
Loa Loa (eye worm) hypothetical protein 0.0021 0.0023 0.003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0103 0.0854
Schistosoma mansoni inositol monophosphatase 0.0042 0.0139 0.0155
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0038 0.0113 0.0201
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0127 0.0223
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0013 0.0035
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0133 0.0154
Loa Loa (eye worm) hypothetical protein 0.0036 0.0106 0.018
Leishmania major cathepsin L-like protease 0.0019 0.0013 0.0011
Schistosoma mansoni jumonji/arid domain-containing protein 0.014 0.0672 0.0773
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0103 0.0113
Schistosoma mansoni protein phosphatase 2C 0.0036 0.0106 0.0117
Schistosoma mansoni retinoic acid receptor RXR 0.0153 0.0743 0.0856
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0142 0.0684 0.0788
Trichomonas vaginalis glucosylceramidase, putative 0.0204 0.1025 0.2846
Loa Loa (eye worm) hypothetical protein 0.027 0.1387 0.251
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0013 0.0035
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0133 0.0229
Schistosoma mansoni rab6-interacting 0.0045 0.0155 0.0174
Trypanosoma brucei NAD+ synthase, putative 0.0094 0.0422 0.0784
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0127 0.0223
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0087 0.0384 0.0692
Plasmodium falciparum enoyl-acyl carrier reductase 0.0212 0.1065 0.427
Brugia malayi Cathepsin L-like precursor 0.0019 0.0013 0.0016
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.033 0.1712 0.6217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0307 0.0567

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.75 uM Inhibitory activity against human glutaminyl cyclase ChEMBL. 16420052
Ki (binding) = 0.75 uM Inhibitory activity against human glutaminyl cyclase ChEMBL. 16420052

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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