Detailed information for compound 350039

Basic information

Technical information
  • TDR Targets ID: 350039
  • Name: 2-methoxy-4-[1-(3,4,5-trimethoxyphenyl)triazo l-4-yl]phenol
  • MW: 357.361 | Formula: C18H19N3O5
  • H donors: 1 H acceptors: 3 LogP: 2.54 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)n1nnc(c1)c1ccc(c(c1)OC)O
  • InChi: 1S/C18H19N3O5/c1-23-15-7-11(5-6-14(15)22)13-10-21(20-19-13)12-8-16(24-2)18(26-4)17(9-12)25-3/h5-10,22H,1-4H3
  • InChiKey: OFVONDWBNYQIFI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methoxy-4-[1-(3,4,5-trimethoxyphenyl)-4-triazolyl]phenol
  • 2-methoxy-4-[1-(3,4,5-trimethoxyphenyl)-1,2,3-triazol-4-yl]phenol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni inositol monophosphatase 0.0043 0.0155 0.0176
Echinococcus granulosus lysine specific demethylase 5A 0.014 0.0684 0.0786
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.0096 0.0445 0.3979
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0039 0.0129 0.0385
Trichomonas vaginalis ABC transporter, putative 0.0025 0.0053 0.0146
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0209 0.0239
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0131 0.0634 0.0632
Loa Loa (eye worm) DR-78 0.0019 0.0023 0.0038
Brugia malayi hypothetical protein 0.0066 0.0281 0.0503
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0089 0.0407 0.3662
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0149 0.0546
Trypanosoma cruzi metacaspase, putative 0.0021 0.0031 0.0056
Schistosoma mansoni loxhd1 0.0066 0.0281 0.0321
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0142 0.0239
Loa Loa (eye worm) multidrug resistance protein 3 0.0025 0.0053 0.0091
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0142 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0068 0.0187
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.0053 0.0146
Echinococcus multilocularis cysteine protease 0.0053 0.0209 0.0207
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0079 0.0191
Brugia malayi beta-lactamase 0.0042 0.0149 0.0265
Schistosoma mansoni multidrug resistance protein 0.0025 0.0053 0.0058
Echinococcus multilocularis JmjC domain containing protein 4 0.0036 0.0116 0.0114
Echinococcus granulosus RUN 0.0066 0.0281 0.0321
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0678 0.3624 1
Schistosoma mansoni rab6-interacting 0.0066 0.0281 0.0321
Trichomonas vaginalis abcb9, putative 0.0025 0.0053 0.0146
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0116 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0142 0.0252
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.007 0.0047
Trypanosoma cruzi metacaspase 5, putative 0.0021 0.0031 0.0056
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0025 0.0053 0.0146
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0325 0.0372
Brugia malayi beta-lactamase family protein 0.0042 0.0149 0.0265
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0116 0.0221
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0142 0.027
Brugia malayi MAP kinase sur-1 0.0118 0.0564 0.1014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0038
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0023 0.0038
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.012 0.0576 0.0661
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0149 0.0546
Toxoplasma gondii transporter, major facilitator family protein 0.0131 0.0634 0.5721
Brugia malayi nuclear receptor NHR-88 0.0019 0.0023 0.0038
Echinococcus multilocularis cysteine protease 0.0053 0.0209 0.0207
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0142 0.014
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0118 0.0564 0.5082
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0061
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0118 0.0564 0.1087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0135 0.0655 0.1265
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.1577 0.4352
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0209 0.0374
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.1577 0.4352
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.0053 0.0146
Leishmania major cytochrome p450-like protein 0.0035 0.0108 0.0204
Trypanosoma brucei NAD+ synthase, putative 0.0096 0.0445 0.0858
Loa Loa (eye worm) hypothetical protein 0.0025 0.0052 0.0089
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0021 0.0031 0.0033
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.007 0.0251
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0036 0.0039
Schistosoma mansoni jumonji domain containing protein 0.0136 0.0663 0.0763
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0025 0.0053 0.005
Echinococcus multilocularis lysine specific demethylase 5A 0.0136 0.0663 0.0661
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0023 0.0021
Echinococcus multilocularis cathepsin L 0.0027 0.0068 0.0065
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0142 0.0252
Trichomonas vaginalis glutaminase, putative 0.0321 0.1674 0.462
Onchocerca volvulus Putative organic anion transporter 0.0131 0.0634 0.113
Brugia malayi hypothetical protein 0.0019 0.0023 0.0038
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0149 0.0411
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0017 0.0012 0.0033
Entamoeba histolytica hypothetical protein 0.0042 0.0149 0.0268
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0209 0.0577
Echinococcus multilocularis muscleblind protein 0.0346 0.1812 0.181
Echinococcus multilocularis RUN 0.0066 0.0281 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0142 0.0252
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0025 0.0053 0.0146
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0052
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0025 0.0053 0.0146
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0023 0.0025
Schistosoma mansoni caspase-7 (C14 family) 0.0021 0.0031 0.0033
Schistosoma mansoni hypothetical protein 0.0199 0.1006 0.1158
Brugia malayi Cathepsin L-like precursor 0.0018 0.0014 0.0021
Echinococcus granulosus multidrug resistance protein 1 0.0025 0.0053 0.0058
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.0031 0.026
Schistosoma mansoni transcription factor btf3 0.0041 0.0142 0.0161
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0117 0.0132
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0564 0.1555
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.007 0.0263
Brugia malayi Cathepsin L-like precursor 0.0053 0.0209 0.0374
Loa Loa (eye worm) hypothetical protein 0.0025 0.0053 0.0091
Plasmodium vivax vivapain-2 0.0053 0.0209 0.183
Echinococcus multilocularis caspase 8 0.0021 0.0031 0.0029
Leishmania major cathepsin L-like protease 0.0053 0.0209 0.04
Onchocerca volvulus 0.0067 0.0282 0.0492
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0149 0.0169
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0142 0.0161
Brugia malayi jmjC domain containing protein 0.0136 0.0663 0.1195
Brugia malayi MH2 domain containing protein 0.0137 0.0664 0.1196
Loa Loa (eye worm) hypothetical protein 0.0131 0.0634 0.1142
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.0012 0.001
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0142 0.0161
Onchocerca volvulus 0.0131 0.0634 0.113
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.1577 0.4352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0678 0.3624 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0068 0.0075
Brugia malayi sodium-independent organic anion transporter family protein 0.0131 0.0634 0.1142
Mycobacterium ulcerans GMP synthase 0.0039 0.0129 0.047
Toxoplasma gondii histone lysine methyltransferase SET1 0.0127 0.0615 0.5543
Loa Loa (eye worm) hypothetical protein 0.1027 0.5535 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.008 0.0356 0.0408
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0061
Schistosoma mansoni hypothetical protein 0.0017 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0052
Trichomonas vaginalis taga, putative 0.0025 0.0053 0.0146
Plasmodium vivax SET domain protein, putative 0.0037 0.0117 0.0993
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.007 0.0251
Echinococcus multilocularis transcription factor btf3 0.0041 0.0142 0.014
Echinococcus multilocularis lysine specific demethylase 6a 0.0036 0.0116 0.0114
Loa Loa (eye worm) hypothetical protein 0.0036 0.0113 0.0199
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0035 0.0016
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0252
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.007 0.0251
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0023 0.0038
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0079 0.0149
Onchocerca volvulus 0.0041 0.0142 0.0239
Entamoeba histolytica cysteine protease, putative 0.0027 0.0068 0.0041
Schistosoma mansoni cathepsin F (C01 family) 0.0053 0.0209 0.0239
Loa Loa (eye worm) hypothetical protein 0.0042 0.0149 0.0265
Brugia malayi hypothetical protein 0.0131 0.0634 0.1142
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0483 0.2558 1
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.1577 0.4352
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0031 0.0086
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0031 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.1006 0.2777
Echinococcus granulosus caspase 8 0.0021 0.0031 0.0033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0142 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0149 0.0283
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0038
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0209 0.0361
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0142 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0113 0.0311
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0108 0.019
Onchocerca volvulus 0.0019 0.0023 0.0025
Brugia malayi Cathepsin L-like cysteine proteinase 0.0036 0.0113 0.0199
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0025 0.0053 0.0098
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.007 0.0251
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0025 0.0084
Echinococcus granulosus multidrug resistance protein 1 0.0025 0.0053 0.0058
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0136 0.0663 0.0661
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.0131 0.0634 0.1142
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0068 0.0126
Plasmodium falciparum JmjC domain-containing protein, putative 0.0036 0.0116 0.0337
Entamoeba histolytica cysteine protease, putative 0.0027 0.0068 0.0041
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0118 0.0564 0.1087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0052 0.0089
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0209 0.0207
Echinococcus granulosus survival motor neuron protein 1 0.0278 0.1437 0.1655
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0025 0.0053 0.0146
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0217 0.1107 1
Loa Loa (eye worm) agrin synaptic family protein 0.0089 0.0407 0.0731
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0331 0.1728 0.6753
Loa Loa (eye worm) inositol-1 0.0043 0.0155 0.0275
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.0096 0.0445 0.1229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1029 0.1988
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0217 0.1107 0.4121
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0142 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1029 0.1988
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0252
Leishmania major cathepsin L-like protease 0.0203 0.1029 0.1988
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0023 0.0024
Plasmodium vivax multidrug resistance protein 1, putative 0.0025 0.0053 0.0408
Loa Loa (eye worm) cysteine protease 0.0053 0.0209 0.0374
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0015 0.0013
Schistosoma mansoni polycystin 1-related 0.0066 0.0281 0.0321
Loa Loa (eye worm) hypothetical protein 0.0089 0.0407 0.0731
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0142 0.0252
Schistosoma mansoni jumonji domain containing protein 0.0036 0.0116 0.0131
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0303 0.1577 0.2846
Schistosoma mansoni lipoxygenase 0.026 0.1339 0.1542
Echinococcus multilocularis caspase 2 0.0069 0.0296 0.0294
Brugia malayi Protein kinase domain containing protein 0.0018 0.0016 0.0024
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.0467 0.084
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0959 0.5166 1
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.1006 0.2777
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0025 0.0053 0.0146
Trypanosoma brucei RNA helicase, putative 0.0119 0.0568 0.1096
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.0664 0.1196
Giardia lamblia Fructose-bisphosphate aldolase 0.0678 0.3624 1
Loa Loa (eye worm) hypothetical protein 0.0278 0.1437 0.2593
Mycobacterium tuberculosis Conserved hypothetical protein 0.0505 0.2682 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0155 0.0285
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0025 0.0053 0.005
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0025 0.0053 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0142 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Toxoplasma gondii NAC domain-containing protein 0.0041 0.0142 0.1265
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.013 0.0499
Brugia malayi Cathepsin L-like precursor 0.0053 0.0209 0.0374
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0089 0.0407 0.0731
Onchocerca volvulus 0.0019 0.0023 0.0025
Plasmodium vivax GMP synthetase, putative 0.0039 0.0129 0.1095
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0031 0.0001
Trypanosoma brucei cytochrome P450, putative 0.0035 0.0108 0.0204
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0467 0.0536
Plasmodium vivax multidomain scavenger receptor, putative 0.0066 0.0281 0.2484
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0678 0.3624 1
Onchocerca volvulus 0.0042 0.0149 0.0252
Brugia malayi hypothetical protein 0.0022 0.0036 0.0061
Schistosoma mansoni phd/f-box containing protein 0.0036 0.0116 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1029 0.1988
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.000000000022833 0.000000000063002
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.007 0.013
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0118 0.0564 0.1087
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0038
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0209 0.0207
Echinococcus multilocularis geminin 0.0199 0.1006 0.1004
Onchocerca volvulus 0.0042 0.0149 0.0252
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0227 0.0407
Echinococcus granulosus JmjC domain containing protein 4 0.0036 0.0116 0.0131
Loa Loa (eye worm) hypothetical protein 0.0131 0.0634 0.1142
Leishmania major cathepsin L-like protease 0.0053 0.0209 0.04
Trypanosoma cruzi major cysteine proteinase, putative 0.016 0.0791 0.1527
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.008 0.0356 0.0408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0209 0.0577
Echinococcus multilocularis muscleblind protein 1 0.0346 0.1812 0.181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0142 0.0252
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0142 0.014
Echinococcus granulosus geminin 0.0199 0.1006 0.1158
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0108 0.019
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.0564 0.0648
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0031 0.0086
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.0053 0.0146
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0025 0.0053 0.0457
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0031 0.0086
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0021 0.0031 0.0029
Brugia malayi hypothetical protein 0.0022 0.0036 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0142 0.0392
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0142 0.0252
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.1006 0.2777
Treponema pallidum fructose-bisphosphate aldolase 0.0678 0.3624 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.0053 0.0146
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0039 0.0129 0.0244
Loa Loa (eye worm) hypothetical protein 0.0037 0.0117 0.0207
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0037 0.0035
Onchocerca volvulus 0.0131 0.0634 0.113
Brugia malayi SPARC precursor 0.0089 0.0407 0.0731
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0483 0.2558 0.9538
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.1577 0.4352
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0209 0.0577
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.007 0.0251
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0038
Brugia malayi jmjC domain containing protein 0.0036 0.0116 0.0206
Echinococcus multilocularis mitogen activated protein kinase 3 0.0118 0.0564 0.0561
Onchocerca volvulus 0.0053 0.0209 0.0361
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0209 0.0577
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.007 0.0263
Brugia malayi hypothetical protein 0.0131 0.0634 0.1142
Echinococcus multilocularis Polycystic kidney disease protein 0.0066 0.0281 0.0279
Echinococcus granulosus lysine specific demethylase 6a 0.0036 0.0116 0.0131
Toxoplasma gondii cathepsin CPL 0.0053 0.0209 0.1872
Loa Loa (eye worm) CXXC zinc finger family protein 0.0067 0.0282 0.0505
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0131 0.0634 0.0632
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0142 0.0252
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.012 0.0576 0.0661
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0031 0.0086
Onchocerca volvulus 0.0053 0.0209 0.0361
Trypanosoma cruzi cruzipain precursor, putative 0.0203 0.1029 0.1988
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.007 0.0047
Entamoeba histolytica cysteine protease, putative 0.0027 0.0068 0.0041
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0023 0.0024
Brugia malayi Muscleblind-like protein 0.0346 0.1812 0.3271
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0023 0.0024
Plasmodium vivax JmjC domain containing protein 0.0036 0.0116 0.0985
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1029 0.1988
Loa Loa (eye worm) beta-lactamase 0.0042 0.0149 0.0265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0209 0.0577
Trypanosoma brucei transcription factor BTF3, putative 0.0041 0.0142 0.027
Trypanosoma cruzi MFS transporter, putative 0.0131 0.0634 0.1223
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0142 0.0161
Echinococcus granulosus mitogen activated protein kinase 3 0.0118 0.0564 0.0648
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0149 0.0169
Onchocerca volvulus 0.0131 0.0634 0.113
Echinococcus multilocularis jumonji domain containing 1A 0.0036 0.0116 0.0114
Echinococcus granulosus multidrug resistance protein 1 0.0025 0.0053 0.0058
Onchocerca volvulus 0.0053 0.0209 0.0361
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.0031 0.026
Echinococcus multilocularis microtubule associated protein 2 0.16 0.8669 0.8669
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.0053 0.0146
Brugia malayi Pre-SET motif family protein 0.0037 0.0117 0.0207
Trichomonas vaginalis esterase, putative 0.0042 0.0149 0.0411
Echinococcus granulosus Polycystic kidney disease protein 0.0066 0.0281 0.0321
Leishmania major cathepsin L-like protease 0.0203 0.1029 0.1988
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0217 0.1107 0.3961
Loa Loa (eye worm) hypothetical protein 0.0069 0.0296 0.053
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.1006 0.2777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1029 0.1988
Trichomonas vaginalis set domain proteins, putative 0.028 0.1448 0.3995
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0232 0.0414
Echinococcus multilocularis expressed protein 0.0089 0.0407 0.0404
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0142 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0142 0.0252
Loa Loa (eye worm) hypothetical protein 0.1027 0.5535 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0053 0.0209 0.0374
Brugia malayi nuclear receptor RXR 0.0019 0.0023 0.0038
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0053 0.0209 0.0705
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0209 0.0577
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0209 0.04
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0217 0.1107 0.4321
Echinococcus granulosus follistatin 0.0089 0.0407 0.0467
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0036 0.0116 0.0221
Echinococcus granulosus netrin receptor unc 5 0.0017 0.001 0.0008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.027 0.1396 0.52
Entamoeba histolytica cysteine protease, putative 0.0027 0.0068 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0068 0.0075
Entamoeba histolytica cysteine protease, putative 0.0053 0.0209 0.0437
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0149 0.0283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0037 0.0063
Echinococcus multilocularis agrin 0.0089 0.0407 0.0404
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0142 0.0239
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0467 0.0536
Trypanosoma cruzi cysteine peptidase, putative 0.0203 0.1029 0.1988
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0052
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0025 0.0053 0.0457
Echinococcus granulosus microtubule associated protein 2 0.16 0.8669 1
Trypanosoma cruzi cruzipain precursor, putative 0.0018 0.0014 0.0022
Entamoeba histolytica cysteine protease, putative 0.0027 0.0068 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0467 0.0536
Echinococcus granulosus agrin 0.0089 0.0407 0.0467
Brugia malayi nuclear receptor NHR-88 0.0041 0.0142 0.0252
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0025 0.0053 0.0058
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0135 0.0655 0.1265
Onchocerca volvulus 0.0057 0.0227 0.0394
Trichomonas vaginalis ABC transporter, putative 0.0025 0.0053 0.0146
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0025 0.0053 0.0058
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0164 0.0817 0.1577
Trypanosoma brucei metacaspase MCA3 0.0021 0.0031 0.0056
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0149 0.0265
Schistosoma mansoni lipoxygenase 0.014 0.0684 0.0787
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0142 0.0252
Brugia malayi hypothetical protein 0.1027 0.5535 1
Brugia malayi Cathepsin L-like precursor 0.0053 0.0209 0.0374
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0038
Brugia malayi hypothetical protein 0.0048 0.0182 0.0325
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0015 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0117 0.0132
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0079 0.0149
Entamoeba histolytica hypothetical protein 0.0042 0.0149 0.0268
Toxoplasma gondii hypothetical protein 0.0155 0.0764 0.6896
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0117 0.0132
Mycobacterium tuberculosis Conserved protein 0.0042 0.0149 0.0546
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0023 0.0038
Brugia malayi ABC transporter family protein 0.0025 0.0053 0.0091
Loa Loa (eye worm) hypothetical protein 0.0039 0.0129 0.0228
Brugia malayi RNA binding protein 0.0074 0.0325 0.0582
Leishmania major hypothetical protein, conserved 0.003 0.0079 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0028 0.007 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0142 0.0252
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0012 0.0011
Echinococcus granulosus cathepsin l1 0.0036 0.0113 0.0127
Loa Loa (eye worm) hypothetical protein 0.0131 0.0634 0.1142
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0023 0.0025
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0021 0.0031 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1029 0.1988
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0155 0.0295
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0108 0.0204
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0068 0.0126
Entamoeba histolytica cysteine protease, putative 0.0027 0.0068 0.0041
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0149 0.0546
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0023 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1029 0.1988
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0131 0.0634 0.0729
Schistosoma mansoni jumonji/arid domain-containing protein 0.014 0.0684 0.0786
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0483 0.2558 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0149 0.0546
Onchocerca volvulus 0.0053 0.0209 0.0361
Onchocerca volvulus 0.0066 0.0281 0.0491
Brugia malayi sodium-independent organic anion transporter family protein 0.0131 0.0634 0.1142
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0118 0.0564 0.1087
Echinococcus multilocularis Ankyrin 0.0017 0.0011 0.0008
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0087 0.0391 0.0388
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0123 0.0593 0.1067
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0959 0.5166 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0025 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.021 0.1065 0.2939
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0031 0.0108
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0142 0.0161
Brugia malayi jmjC domain containing protein 0.014 0.0684 0.1232
Brugia malayi hypothetical protein 0.0278 0.1437 0.2593
Entamoeba histolytica cysteine protease, putative 0.0027 0.0068 0.0041
Schistosoma mansoni nuclear receptor 0.0019 0.0023 0.0024
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0031 0.0086
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0142 0.0161
Schistosoma mansoni hypothetical protein 0.0057 0.0227 0.026
Brugia malayi cathepsin L-like precursor 0.0036 0.0113 0.0199
Loa Loa (eye worm) hypothetical protein 0.0042 0.0149 0.0265
Plasmodium falciparum cysteine proteinase falcipain 3 0.0053 0.0209 0.0705
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0031 0.0086
Brugia malayi Melibiase family protein 0.008 0.0356 0.064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0142 0.0252
Echinococcus granulosus phd:f box containing protein 0.0036 0.0116 0.0131
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0209 0.0577
Echinococcus granulosus mitogen activated protein kinase 0.0118 0.0564 0.0648
Trypanosoma brucei protein kinase, putative 0.0118 0.0564 0.1087
Schistosoma mansoni cpg binding protein 0.0067 0.0282 0.0322
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0325 0.0582
Onchocerca volvulus 0.0025 0.0053 0.0078
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0036 0.0061
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0325 0.0582
Brugia malayi nuclear receptor NHR-67 0.0019 0.0023 0.0038
Echinococcus granulosus cathepsin L 0.0027 0.0068 0.0075
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0118 0.0564 0.1087
Mycobacterium ulcerans hypothetical protein 0.0028 0.007 0.0251
Echinococcus granulosus caspase 0.0021 0.0031 0.0033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0467 0.0536
Echinococcus granulosus tar DNA binding protein 0.0074 0.0325 0.0372
Toxoplasma gondii ABC1 family protein 0.0042 0.0149 0.1325
Leishmania major cathepsin L-like protease 0.0053 0.0209 0.04
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0346 0.1812 0.3271
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0155 0.0295
Brugia malayi steroid hormone receptor 0.0041 0.0142 0.0252
Echinococcus multilocularis multidrug resistance protein 1 0.0025 0.0053 0.005
Brugia malayi Cytochrome P450 family protein 0.0035 0.0108 0.019
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Brugia malayi secreted modular calcium-binding protein 1 0.0089 0.0407 0.0731
Leishmania major hypothetical protein, conserved 0.0036 0.0116 0.0221
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0068 0.0118
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0038
Brugia malayi ecdysone receptor 0.0019 0.0023 0.0038
Brugia malayi ecdysteroid receptor 0.0041 0.0142 0.0252
Plasmodium vivax unspecified product 0.0027 0.0068 0.0542
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0155 0.138
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.001 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0025 0.0053 0.0188
Plasmodium falciparum basic transcription factor 3b, putative 0.0041 0.0142 0.0439
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.0053 0.0146
Loa Loa (eye worm) RNA binding protein 0.0074 0.0325 0.0582
Loa Loa (eye worm) RecQ helicase 0.0025 0.0052 0.0089
Entamoeba histolytica cysteine proteinase 2 0.0027 0.0068 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0142 0.014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.000000000022833 0.000000000063002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0023 0.0024
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.0053 0.0146
Brugia malayi Cathepsin L-like precursor 0.0036 0.0113 0.0199
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0089 0.0407 0.3662
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.007 0.0251
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.0053 0.0146
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0135 0.0657 0.0655
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.007 0.0251
Echinococcus granulosus lipoxygenase domain containing protein 0.0066 0.0281 0.0321
Loa Loa (eye worm) hypothetical protein 0.0036 0.0113 0.0199
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0149 0.0146
Loa Loa (eye worm) hypothetical protein 0.0066 0.0281 0.0503
Onchocerca volvulus Putative organic anion transporter 0.0131 0.0634 0.113
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0025 0.0084
Onchocerca volvulus Glucosylceramidase homolog 0.0199 0.1006 0.1804
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0142 0.0239
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0142 0.0252
Schistosoma mansoni glutaminase 0.0321 0.1674 0.1929
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0061
Entamoeba histolytica transcription factor BTF3, putative 0.0041 0.0142 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Onchocerca volvulus 0.0048 0.0182 0.0312
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0014 0.0021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0142 0.0161
Onchocerca volvulus 0.0036 0.0113 0.0186
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0142 0.0161
Brugia malayi AMP-binding enzyme family protein 0.0028 0.007 0.0122
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.0053 0.0146
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0142 0.0161
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.000000000022833 0.000000000063002
Onchocerca volvulus 0.0042 0.0149 0.0252
Echinococcus granulosus transcription factor btf3 0.0041 0.0142 0.0161
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0186 0.0933 0.1801
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0025 0.0053 0.0146
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0117 0.0115
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.0053 0.0146
Entamoeba histolytica cysteine protease, putative 0.0027 0.0068 0.0041
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0252
Onchocerca volvulus 0.0053 0.0209 0.0361
Brugia malayi AMP-binding enzyme family protein 0.0028 0.007 0.0122
Brugia malayi jmjC domain containing protein 0.0036 0.0116 0.0206
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0079 0.0149
Echinococcus granulosus cathepsin L cysteine protease 0.0027 0.0068 0.0075
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0142 0.014
Loa Loa (eye worm) hypothetical protein 0.0089 0.0407 0.0731
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0052 0.0049
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0023 0.0038
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.001 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0142 0.0392
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0142 0.014
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0025 0.0053 0.0086
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0325 0.0322
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0036 0.0116 0.1031
Echinococcus multilocularis ATP binding cassette sub family B 0.0025 0.0052 0.0049
Schistosoma mansoni smdr2 0.0025 0.0053 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0149 0.0283
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.0122
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0564 0.1555
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0031 0.0086
Trichomonas vaginalis ABC transporter, putative 0.0025 0.0053 0.0146
Plasmodium vivax metacaspase 1, putative 0.0021 0.0031 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0142 0.0252
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0031 0.0108
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.012 0.0576 0.0661
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0142 0.0252
Schistosoma mansoni cpg binding protein 0.007 0.0302 0.0346
Schistosoma mansoni caspase-3 (C14 family) 0.0021 0.0031 0.0033
Loa Loa (eye worm) fibroinase 0.0053 0.0209 0.0374
Onchocerca volvulus Cell death protein 3 homolog 0.0069 0.0296 0.0518
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0142 0.0161
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0068 0.0075
Plasmodium vivax basic transcription factor 3b, putative 0.0041 0.0142 0.122
Plasmodium falciparum LCCL domain-containing protein 0.0066 0.0281 0.0989
Mycobacterium tuberculosis Conserved protein 0.0042 0.0149 0.0546
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0483 0.2558 0.9538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0113 0.0311
Mycobacterium ulcerans glutaminase 0.0321 0.1674 0.6239
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0142 0.0161
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0118 0.0564 0.1087
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.0031 0.026
Onchocerca volvulus Cathepsin L homolog 0.0053 0.0209 0.0361
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0142 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0142 0.0392
Brugia malayi jmjC domain containing protein 0.0036 0.0116 0.0206
Brugia malayi sodium-independent organic anion transporter family protein 0.0131 0.0634 0.1142
Schistosoma mansoni organic anion transporter 0.0131 0.0634 0.0729
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0118 0.0564 0.1014
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0157 0.0776 0.0892
Leishmania major hypothetical protein, conserved 0.0042 0.0149 0.0283
Brugia malayi hypothetical protein 0.0019 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0042 0.0149 0.0265
Plasmodium falciparum multidrug resistance protein 1 0.0025 0.0053 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.1006 0.2777
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0678 0.3624 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0346 0.1812 0.3271
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0155 0.0427
Brugia malayi hypothetical protein 0.0042 0.0149 0.0264
Echinococcus granulosus apoptotic protease activating factor 1 0.0048 0.0182 0.0207
Onchocerca volvulus 0.0131 0.0634 0.113
Onchocerca volvulus 0.1027 0.5535 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0068 0.0041
Loa Loa (eye worm) hypothetical protein 0.0025 0.0053 0.0091
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0025 0.0053 0.005
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0142 0.0161
Leishmania major NAD synthase, putative 0.0096 0.0445 0.0858
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0052
Plasmodium vivax vivapain-2 0.0053 0.0209 0.183
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0135 0.0655 0.1265
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0142 0.0252
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.001 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0068 0.0126
Brugia malayi TAR-binding protein 0.0074 0.0325 0.0582
Schistosoma mansoni caspase-7 (C14 family) 0.0069 0.0296 0.0339
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0025 0.0052 0.0057
Echinococcus multilocularis pol protein 0.1843 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.000000000022833 0.000000000063002
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0325 0.0372
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0068 0.0041
Mycobacterium tuberculosis Conserved protein 0.0042 0.0149 0.0546
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0155 0.0295
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.000000000022833 0.000000000063002
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.012 0.0576 0.0573
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0142 0.0252
Brugia malayi hypothetical protein 0.0019 0.0022 0.0035
Schistosoma mansoni jumonji/arid domain-containing protein 0.014 0.0684 0.0786
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0061
Schistosoma mansoni inositol monophosphatase 0.0043 0.0155 0.0176
Toxoplasma gondii protease inhibitor PI2 0.0089 0.0407 0.3662
Echinococcus multilocularis cpg binding protein 0.007 0.0302 0.03
Echinococcus multilocularis multidrug resistance protein 1 0.0025 0.0053 0.005
Leishmania major mitochondrial DNA polymerase beta 0.0959 0.5166 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0149 0.0411
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0467 0.0536
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.0206
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0023 0.0021
Loa Loa (eye worm) runx1 0.0129 0.0622 0.112
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0454 0.2401 0.4646
Loa Loa (eye worm) hypothetical protein 0.0089 0.0407 0.0731
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0142 0.014
Brugia malayi Cathepsin L-like precursor 0.0053 0.0209 0.0374
Schistosoma mansoni rab6-interacting 0.0066 0.0281 0.0321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0068 0.0126
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.012 0.0576 0.0661
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0142 0.0252
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0155 0.0427
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0149 0.0546
Trichomonas vaginalis abcb9, putative 0.0025 0.0053 0.0146
Echinococcus granulosus cpg binding protein 0.007 0.0302 0.0346
Plasmodium vivax unspecified product 0.0018 0.0014 0.0052
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0025 0.0053 0.0146
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0012 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0015 0.0014
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.0053 0.0146
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0035 0.0108 0.0393
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0331 0.1728 0.6441
Mycobacterium ulcerans NAD synthetase 0.0096 0.0445 0.1653
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0036 0.0116 0.1031
Mycobacterium tuberculosis Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) 0.0096 0.0445 0.1653
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0036 0.0039
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0142 0.014
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.012 0.0576 0.0661
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0116 0.0206
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0038
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0031 0.0086
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.0053 0.0146
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.0664 0.1196
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0149 0.0169
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0014 0.0022
Trypanosoma cruzi cysteine protease, putative 0.0027 0.0068 0.0126
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.007 0.0047
Loa Loa (eye worm) hypothetical protein 0.0042 0.0149 0.0265
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0011 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0325 0.0372
Entamoeba histolytica cysteine protease, putative 0.0027 0.0068 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.1006 0.2777
Echinococcus multilocularis pol protein 0.1843 1 1
Entamoeba histolytica hypothetical protein 0.0041 0.0142 0.025
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0454 0.2401 0.4646
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0025 0.0053 0.0146
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0149 0.0265
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0038
Echinococcus granulosus nuclear factor of activated T cells 5 0.0087 0.0391 0.0448
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0149 0.0146
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0113 0.0127
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0102 0.0115
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.001 0.0013
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0031 0.0209
Schistosoma mansoni retinoic acid receptor RXR 0.0157 0.0776 0.0892
Brugia malayi hypothetical protein 0.003 0.0079 0.0139
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0143 0.0697 0.0801
Brugia malayi beta-NAC-like protein 0.0041 0.0142 0.0252
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0052
Onchocerca volvulus 0.0037 0.0117 0.0194
Loa Loa (eye worm) hypothetical protein 0.008 0.0356 0.064
Trypanosoma cruzi cysteine peptidase, putative 0.0203 0.1029 0.1988
Brugia malayi nuclear receptor RXR 0.0022 0.0036 0.0061
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0038
Brugia malayi nuclear hormone receptor 0.0019 0.0023 0.0038
Schistosoma mansoni protein phosphatase 2C 0.0036 0.0116 0.0131
Trypanosoma cruzi cysteine peptidase, putative 0.0203 0.1029 0.1988
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.0053 0.0146
Schistosoma mansoni microtubule-associated protein tau 0.16 0.8669 1
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0068 0.0041
Brugia malayi jmjC domain containing protein 0.0036 0.0116 0.0206
Echinococcus granulosus cathepsin L cysteine proteinase 0.0053 0.0209 0.0239
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.004 0.0137 0.0135
Loa Loa (eye worm) CYP4Cod1 0.0035 0.0108 0.019
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0959 0.5166 1
Brugia malayi Cathepsin L-like precursor 0.0053 0.0209 0.0374
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0023 0.0038
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0149 0.0546
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0025 0.0053 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.000000000022833 0.000000000063002
Onchocerca volvulus 0.0131 0.0634 0.113
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0053 0.0209 0.0705
Leishmania major metacaspase, putative 0.0021 0.0031 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0209 0.0577
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0031 0.0086
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0149 0.0546
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0252
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0149 0.1281
Brugia malayi cathepsin F-like cysteine proteinase 0.0018 0.0014 0.0021
Echinococcus granulosus cathepsin l1 0.0053 0.0209 0.0239
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0021 0.0031 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.007 0.0251
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0023 0.0024
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0025 0.0053 0.0058
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0108 0.0204
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0142 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0068 0.0187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0678 0.3624 1
Brugia malayi Cytochrome P450 family protein 0.0035 0.0108 0.019
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0039 0.0129 0.1141
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0036 0.006
Brugia malayi prostaglandin transporter 0.0131 0.0634 0.1142
Brugia malayi nuclear hormone receptor 0.0041 0.0142 0.0252
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0678 0.3624 1
Brugia malayi GMP synthase 0.0039 0.0129 0.0228
Onchocerca volvulus 0.0053 0.0209 0.0361
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.013 0.0476
Brugia malayi Cytochrome P450 family protein 0.0057 0.0232 0.0414
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0155 0.0152
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0036 0.0061
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0052 0.0142
Brugia malayi Cathepsin L-like precursor 0.0036 0.0113 0.0199
Onchocerca volvulus Cathepsin F homolog 0.0053 0.0209 0.0361
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0038
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0142 0.027
Entamoeba histolytica cysteine protease, putative 0.0027 0.0068 0.0041
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.004 0.0137 0.0155
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0079 0.0697
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0142 0.0252
Trypanosoma brucei metacaspase MCA2 0.0021 0.0031 0.0056
Plasmodium falciparum enoyl-acyl carrier reductase 0.0217 0.1107 0.4256
Trypanosoma brucei metacaspase 5, putative 0.0021 0.0031 0.0056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0209 0.0577
Onchocerca volvulus Putative organic anion transporter 0.0131 0.0634 0.113
Echinococcus granulosus cysteine protease 0.0027 0.0068 0.0075
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0089 0.0407 0.0731
Brugia malayi Papain family cysteine protease containing protein 0.0053 0.0209 0.0374
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0058 0.0234 0.0267
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0039 0.0129 0.0126
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0142 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1029 0.1988
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0217 0.1107 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.012 0.0576 0.0573
Echinococcus multilocularis lipoxygenase domain containing protein 0.0066 0.0281 0.0279
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0017 0.0011 0.0009
Plasmodium vivax vivapain-3 0.0027 0.0068 0.0542
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0031 0.0086
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0454 0.2401 0.4646
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0036 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0116 0.0206
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0155 0.0176
Onchocerca volvulus 0.0028 0.007 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0678 0.3624 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.0206
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1029 0.1988
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0027 0.0068 0.0126
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0025 0.0053 0.005
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0089 0.0407 0.3662
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0155 0.0427
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0053 0.0209 0.0577
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0031 0.0086
Trichomonas vaginalis hypothetical protein 0.0217 0.1107 0.3054
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0089 0.0407 0.0731
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0325 0.0372
Trypanosoma brucei Metacaspase-4 0.0021 0.0031 0.0056
Echinococcus granulosus death domain containing protein 0.0017 0.001 0.0008
Trypanosoma cruzi NAD+ synthase, putative 0.0096 0.0445 0.0858
Echinococcus granulosus Ankyrin 0.0017 0.0011 0.0009
Echinococcus granulosus arachidonate 5 lipoxygenase 0.026 0.1339 0.1542
Brugia malayi conserved hypotetical protein 0.0019 0.0023 0.0038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0037 0.004
Entamoeba histolytica cysteine proteinase 1, putative 0.0027 0.0068 0.0041
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0015 0.0013
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.008 0.0356 0.0983
Echinococcus multilocularis Protein lozenge 0.0129 0.0622 0.062
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0155 0.0295
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0023 0.0038
Schistosoma mansoni nuclear receptor 0.0019 0.0023 0.0024
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0068 0.0041
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0118 0.0564 0.1087
Schistosoma mansoni coup transcription factor 0.0041 0.0142 0.0161
Loa Loa (eye worm) hypothetical protein 0.0048 0.0182 0.0325
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0025 0.0084
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0142 0.014
Schistosoma mansoni survival motor neuron protein 0.0057 0.0227 0.026
Echinococcus multilocularis cathepsin L cysteine protease 0.0053 0.0209 0.0207
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0023 0.0024
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.0096 0.0445 0.1639
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0246 0.1263 0.2278
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Leishmania major p-glycoprotein 0.0025 0.0053 0.0098
Toxoplasma gondii Alpha-galactosidase 0.0017 0.0011 0.0074
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0149 0.0411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1029 0.1988
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0325 0.0582
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0142 0.0161
Trichomonas vaginalis ABC transporter, putative 0.0025 0.0053 0.0146
Entamoeba histolytica cysteine protease, putative 0.0027 0.0068 0.0041
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.001 0.0013
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0325 0.0372
Loa Loa (eye worm) hypothetical protein 0.0017 0.0011 0.0015
Mycobacterium leprae Probable lipase LipE 0.0042 0.0149 0.0573
Trichomonas vaginalis glucosylceramidase, putative 0.021 0.1065 0.2939
Mycobacterium ulcerans hypothetical protein 0.0042 0.0149 0.0546
Brugia malayi hypothetical protein 0.0066 0.0281 0.0503
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0079 0.0191
Loa Loa (eye worm) hypothetical protein 0.0066 0.0281 0.0503
Loa Loa (eye worm) glutaminase 0.0321 0.1674 0.3022
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.1006 0.2777
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0116 0.0206
Toxoplasma gondii melibiase subfamily protein 0.012 0.0576 0.5191
Schistosoma mansoni follistatin 0.0089 0.0407 0.0467
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0096 0.0445 0.0511
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0068 0.0126
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0209 0.0437
Echinococcus granulosus Solute carrier organic anion transporter family 0.0131 0.0634 0.0729
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0023 0.0021
Trypanosoma cruzi metacaspase, putative 0.0021 0.0031 0.0056
Loa Loa (eye worm) ICD-1 protein 0.0041 0.0142 0.0252
Schistosoma mansoni multidrug resistance protein 0.0025 0.0053 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0142 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0142 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Echinococcus multilocularis dnaJ subfamily B 0.0948 0.5105 0.5104
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.026 0.1339 0.1336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Echinococcus granulosus cathepsin l cysteine peptidase 0.0053 0.0209 0.0239
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0007 0.0042
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0089 0.0407 0.0731
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0031 0.0086
Echinococcus multilocularis apoptotic protease activating factor 1 0.0048 0.0182 0.018
Schistosoma mansoni hypothetical protein 0.0042 0.0149 0.0169
Loa Loa (eye worm) hypothetical protein 0.003 0.0079 0.0139
Loa Loa (eye worm) doublecortin family protein 0.0066 0.0281 0.0503
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0023 0.0024
Schistosoma mansoni zinc finger protein 0.0019 0.0023 0.0024
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0053 0.0209 0.0207
Schistosoma mansoni cpg binding protein 0.007 0.0302 0.0346
Echinococcus multilocularis lipoxygenase domain containing protein 0.0066 0.0281 0.0279
Trichomonas vaginalis glucosylceramidase, putative 0.0303 0.1577 0.4352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0678 0.3624 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0066 0.0281 0.0321
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0089 0.0407 0.3662
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0039 0.0129 0.0145
Schistosoma mansoni hypothetical protein 0.0119 0.0568 0.0653
Plasmodium vivax vivapain-1 0.0027 0.0068 0.0542
Brugia malayi Inositol-1 0.0043 0.0155 0.0275
Loa Loa (eye worm) glutaminase 2 0.0321 0.1674 0.3022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0203 0.1029 0.1988
Trypanosoma brucei metacaspase 0.0021 0.0031 0.0056
Loa Loa (eye worm) hypothetical protein 0.0131 0.0634 0.1142
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.007 0.013
Leishmania major cysteine peptidase A (CPA) 0.0053 0.0209 0.04
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0467 0.0465
Schistosoma mansoni hypothetical protein 0.0948 0.5105 0.5887
Echinococcus granulosus muscleblind protein 0.0346 0.1812 0.2088
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0061
Leishmania major cathepsin L-like protease 0.0203 0.1029 0.1988
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0025 0.0053 0.0091
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0149 0.0411
Brugia malayi CXXC zinc finger family protein 0.0067 0.0282 0.0505
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0068 0.0118
Echinococcus multilocularis follistatin 0.0089 0.0407 0.0404
Giardia lamblia Kinase, CMGC MAPK 0.0118 0.0564 0.0372
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0039 0.0129 0.0244
Leishmania major basic transcription factor 3a, putative 0.0041 0.0142 0.027
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0018 0.0014 0.0021
Onchocerca volvulus 0.0066 0.0281 0.0491
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0564 0.1555
Loa Loa (eye worm) hypothetical protein 0.0131 0.0634 0.1142
Entamoeba histolytica cysteine proteinase, putative 0.0053 0.0209 0.0437
Brugia malayi Doublecortin family protein 0.0066 0.0281 0.0503
Echinococcus granulosus bloom syndrome protein 0.0025 0.0052 0.0057
Onchocerca volvulus 0.0089 0.0407 0.0718
Brugia malayi Death domain containing protein 0.0017 0.001 0.0013
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0217 0.1107 0.4256
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0678 0.3624 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0031 0.0211
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.0564 0.1555
Loa Loa (eye worm) hypothetical protein 0.0131 0.0634 0.1142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0142 0.0252
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0089 0.0407 0.0731
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.000000000022833 0.000000000063002
Brugia malayi glutaminase DH11.1 0.0321 0.1674 0.3022
Schistosoma mansoni hypothetical protein 0.0066 0.0281 0.0321
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0036 0.0116 0.0131
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.0122
Mycobacterium ulcerans hypothetical protein 0.0505 0.2682 1
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0483 0.2558 1
Brugia malayi tailless protein 0.0019 0.0023 0.0038
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0136 0.0663 0.0763
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0149 0.0169
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0149 0.0546
Brugia malayi Uncoordinated protein 44 0.0017 0.001 0.0013
Entamoeba histolytica NAD synthetase, putative 0.0096 0.0445 0.1099
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.0122
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0117 0.0115
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.000000000022833 0.000000000063002
Trypanosoma cruzi NAD+ synthase, putative 0.0096 0.0445 0.0858
Mycobacterium ulcerans beta-lactamase 0.0042 0.0149 0.0546
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0042 0.0149 0.0265
Schistosoma mansoni multidrug resistance protein 0.0025 0.0053 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0252
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0303 0.1577 0.2846
Trichomonas vaginalis abcb9, putative 0.0025 0.0053 0.0146
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0079 0.0649
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.0031 0.0086
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0142 0.014
Schistosoma mansoni agrin 0.0089 0.0407 0.0467
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0252
Leishmania major cathepsin L-like protease 0.0053 0.0209 0.04
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0135 0.0655 0.1265
Brugia malayi Cell death protein 3 precursor 0.0069 0.0296 0.053
Mycobacterium ulcerans lipase LipD 0.0042 0.0149 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0031 0.0086
Entamoeba histolytica cysteine protease, putative 0.0027 0.0068 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0038
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0149 0.0411
Echinococcus multilocularis caspase 0.0021 0.0031 0.0029
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.001 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0678 0.3624 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0052 0.0142
Schistosoma mansoni organic anion transporter 0.0131 0.0634 0.0729
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0149 0.0169
Echinococcus granulosus dnaJ subfamily B 0.0948 0.5105 0.5887
Loa Loa (eye worm) jmjC domain-containing protein 0.014 0.0684 0.1232
Entamoeba histolytica cysteine protease, putative 0.0027 0.0068 0.0041
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0149 0.0546
Echinococcus multilocularis mitogen activated protein kinase 0.0118 0.0564 0.0561
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.0113 0.0167
Loa Loa (eye worm) hypothetical protein 0.0042 0.0149 0.0265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0053 0.0209 0.0577
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0015 0.0014
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0023 0.0024
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0142 0.0161
Schistosoma mansoni cathepsin s 0.0018 0.0014 0.0013
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0149 0.0573
Leishmania major cathepsin L-like protease 0.0053 0.0209 0.04
Brugia malayi Pre-SET motif family protein 0.0246 0.1263 0.2278
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.007 0.013
Echinococcus multilocularis survival motor neuron protein 1 0.0278 0.1437 0.1435
Schistosoma mansoni hypothetical protein 0.0199 0.1006 0.1158
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0023 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0467 0.0465
Entamoeba histolytica hypothetical protein 0.0042 0.0149 0.0268
Brugia malayi beta-lactamase family protein 0.0042 0.0149 0.0265
Schistosoma mansoni netrin receptor unc5 0.0017 0.001 0.0008
Mycobacterium leprae PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) 0.0096 0.0445 0.1733
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0053 0.0209 0.0577
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0483 0.2558 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0037
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.0096 0.0445 0.401
Schistosoma mansoni phosphatidylserine receptor 0.0036 0.0116 0.0131
Echinococcus granulosus jumonji domain containing 1A 0.0036 0.0116 0.0131
Echinococcus granulosus caspase 2 0.0069 0.0296 0.0339
Echinococcus multilocularis phd:f box containing protein 0.0036 0.0116 0.0114
Echinococcus multilocularis pol protein 0.1843 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0117 0.0132
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0142 0.0252
Trypanosoma cruzi metacaspase 5, putative 0.0021 0.0031 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0036 0.0061
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0155 0.0569
Brugia malayi multidrug resistance protein 3 0.0025 0.0053 0.0091
Trypanosoma cruzi metacaspase, putative 0.0021 0.0031 0.0056
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0483 0.2558 0.6646
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0117 0.0132
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0131 0.0634 0.1142
Schistosoma mansoni lozenge 0.0129 0.0622 0.0715
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0025 0.0053 0.0146
Schistosoma mansoni hypothetical protein 0.0048 0.0182 0.0207
Entamoeba histolytica hypothetical protein 0.0042 0.0149 0.0268
Loa Loa (eye worm) hypothetical protein 0.0036 0.0113 0.0199
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0117 0.1039
Plasmodium falciparum cysteine proteinase falcipain 1 0.0027 0.0068 0.0145
Trypanosoma cruzi metacaspase, putative 0.0021 0.0031 0.0056
Brugia malayi Cathepsin L-like precursor 0.0053 0.0209 0.0374
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0331 0.1728 0.6441
Loa Loa (eye worm) ctsf protein 0.0053 0.0209 0.0374
Loa Loa (eye worm) hypothetical protein 0.0053 0.0209 0.0374
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0217 0.1107 0.4121
Onchocerca volvulus 0.028 0.1448 0.2604
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.007 0.0251
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.0467 0.084
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0052
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0089 0.0407 0.0731
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0014 0.0021
Schistosoma mansoni GMP synthetase 0.0039 0.0129 0.0145
Onchocerca volvulus 0.0053 0.0209 0.0361

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 10000 nM Cytotoxicity against breast cancer MDA-MB231 cell line by MTT assay ChEMBL. 16420033
IC50 (functional) > 10000 nM Cytotoxicity against breast cancer MDA-MB231 cell line by MTT assay ChEMBL. 16420033

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16420033

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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