Detailed information for compound 281248

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 326.479 | Formula: C18H18N2S2
  • H donors: 0 H acceptors: 1 LogP: 4.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C1CSC(S1)(CCn1cncc1)c1ccc2c(c1)cccc2
  • InChi: 1S/C18H18N2S2/c1-2-4-16-13-17(6-5-15(16)3-1)18(21-11-12-22-18)7-9-20-10-8-19-14-20/h1-6,8,10,13-14H,7,9,11-12H2
  • InChiKey: RGNVFBHCMKXUJN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0032 0.0079 0.0119
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0113 0.0403 0.0534
Trichomonas vaginalis helicase, putative 0.0014 0.0007 0.0024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0189
Schistosoma mansoni agrin 0.0086 0.0292 0.0439
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0009 0.0012
Loa Loa (eye worm) inositol-1 0.0041 0.0116 0.0283
Loa Loa (eye worm) cysteine protease 0.0052 0.0157 0.0391
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0034 0.0159
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0044 0.017
Loa Loa (eye worm) MH2 domain-containing protein 0.0648 0.2552 0.6555
Leishmania major cathepsin L-like protease 0.0052 0.0157 0.0208
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0076 0.0254 0.0254
Loa Loa (eye worm) ctsf protein 0.0052 0.0157 0.0391
Brugia malayi Protein kinase domain containing protein 0.0017 0.0018 0.0032
Echinococcus multilocularis chromobox protein 1 0.0042 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0086 0.0292 0.0738
Trypanosoma brucei metacaspase 0.002 0.0029 0.0038
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0052 0.0157 0.0391
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0189
Trypanosoma cruzi cysteine peptidase, putative 0.0198 0.0743 0.0987
Plasmodium falciparum cysteine proteinase falcipain 3 0.0052 0.0157 0.0845
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0034 0.0132
Echinococcus granulosus caspase 0.002 0.0029 0.0043
Echinococcus multilocularis cysteine protease 0.0052 0.0157 0.0157
Plasmodium vivax SET domain protein, putative 0.0035 0.0089 0.1076
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0038 0.0103 0.0103
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0015 0.0009 0.001
Onchocerca volvulus 0.0052 0.0157 0.0391
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0089 0.0089
Brugia malayi GMP synthase 0.0037 0.0097 0.0236
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0014 0.0021
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0089 0.0133
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0069 0.0224 0.0337
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0084 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0713 0.2794
Onchocerca volvulus 0.0052 0.0157 0.0391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0035 0.0135
Echinococcus multilocularis RUN 0.0064 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Leishmania major cytochrome p450-like protein 0.0015 0.0009 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0034 0.0132
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0086 0.0295 0.0295
Echinococcus multilocularis pol protein 0.2503 1 1
Brugia malayi Nuclear hormone receptor E75 0.0032 0.0079 0.0189
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0056 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0008 0.0027
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0044 0.0331
Trypanosoma brucei pteridine reductase 1 0.0014 0.0006 0.0007
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0015 0.0009 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.034 0.086
Onchocerca volvulus 0.0125 0.0452 0.1149
Brugia malayi Cathepsin L-like precursor 0.0052 0.0157 0.0391
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0099
Mycobacterium tuberculosis Conserved hypothetical protein 0.0994 0.3939 1
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0079 0.0119
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0056 0.013
Echinococcus multilocularis lipoxygenase domain containing protein 0.0064 0.0206 0.0206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Echinococcus granulosus geminin 0.019 0.0713 0.1071
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0115 0.0411 0.0617
Loa Loa (eye worm) hypothetical protein 0.0069 0.0224 0.0564
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0115 0.0411 0.0617
Schistosoma mansoni microtubule-associated protein tau 0.1671 0.666 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0015 0.0009 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.003 0.0113
Schistosoma mansoni polycystin 1-related 0.0064 0.0206 0.031
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0461 0.1802 1
Plasmodium falciparum metacaspase 1 0.002 0.0029 0.013
Echinococcus granulosus dnaJ subfamily B 0.0907 0.3589 0.5389
Echinococcus granulosus death domain containing protein 0.0016 0.0014 0.0021
Onchocerca volvulus 0.0054 0.0167 0.0414
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0086 0.0295 0.0744
Plasmodium vivax multidrug resistance protein 1, putative 0.0024 0.0044 0.0496
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0189
Echinococcus multilocularis pol protein 0.2503 1 1
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0461 0.1802 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0084 0.0203
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0069 0.0224 0.0564
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.0107 0.0415
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0015 0.0009 0.001
Onchocerca volvulus 0.0035 0.0089 0.0214
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0027 0.0057 0.0076
Trichomonas vaginalis hypothetical protein 0.0208 0.0784 0.307
Plasmodium vivax GMP synthetase, putative 0.0037 0.0097 0.1177
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0046 0.0177
Brugia malayi MH1 domain containing protein 0.0024 0.0047 0.0107
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0208 0.0784 0.4331
Toxoplasma gondii protease inhibitor PI2 0.0086 0.0292 0.2462
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0029 0.03
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0713 0.2794
Brugia malayi hypothetical protein 0.0046 0.0135 0.0333
Loa Loa (eye worm) hypothetical protein 0.0331 0.1278 0.3276
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0098 0.0235
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0189
Brugia malayi Cytochrome P450 family protein 0.0056 0.0173 0.043
Echinococcus granulosus mothers against decapentaplegic 5 0.0044 0.0126 0.019
Onchocerca volvulus 0.0125 0.0452 0.1149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Loa Loa (eye worm) RecQ helicase 0.0024 0.0046 0.0104
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0089 0.0133
Brugia malayi latrophilin 2 splice variant baaae 0.0186 0.0696 0.1776
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.013
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0029 0.013
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0017 0.0018 0.0032
Echinococcus multilocularis Protein lozenge 0.0123 0.0444 0.0444
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0029 0.0059
Trypanosoma cruzi metacaspase, putative 0.002 0.0029 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0069 0.0224 0.0564
Echinococcus granulosus survival motor neuron protein 1 0.0266 0.1015 0.1525
Echinococcus granulosus TGF beta signal transducer SmadC 0.0044 0.0126 0.019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0025 0.0048
Mycobacterium tuberculosis Conserved protein 0.004 0.0111 0.0269
Echinococcus granulosus ecdysone induced protein 78C 0.0069 0.0224 0.0337
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0044 0.017
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0107 0.0141
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0079 0.0118
Echinococcus granulosus lipoxygenase domain containing protein 0.0064 0.0206 0.031
Brugia malayi photoreceptor-specific nuclear receptor 0.0069 0.0224 0.0564
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0648 0.255 1
Schistosoma mansoni RAR-like nuclear receptor 0.0069 0.0224 0.0337
Schistosoma mansoni Smad4 0.0044 0.0126 0.019
Onchocerca volvulus 0.004 0.0111 0.0272
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0056 0.0074
Entamoeba histolytica cysteine protease, putative 0.0027 0.0056 0.0218
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0023 0.0043 0.0065
Onchocerca volvulus Putative organic anion transporter 0.0125 0.0452 0.1149
Brugia malayi TAR-binding protein 0.0071 0.0235 0.059
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0235 0.0893 0.2284
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0265 0.1014 0.1347
Brugia malayi beta-lactamase family protein 0.004 0.0111 0.0272
Schistosoma mansoni inositol monophosphatase 0.0041 0.0116 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0069 0.0224 0.0564
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0089 0.0214
Brugia malayi Cytochrome P450 family protein 0.0015 0.0009 0.001
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0015 0.0009 0.001
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0044 0.017
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0015 0.0009 0.001
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0116 0.045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0056 0.0218
Echinococcus multilocularis ecdysone induced protein 78C 0.0069 0.0224 0.0224
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0056 0.0073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0157 0.0614
Loa Loa (eye worm) hypothetical protein 0.0066 0.0215 0.0538
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0111 0.0148
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0111 0.0167
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0084 0.0111
Loa Loa (eye worm) MH1 domain-containing protein 0.002 0.0028 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0056 0.0218
Loa Loa (eye worm) hypothetical protein 0.0024 0.0044 0.0099
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.0092 0.0319 0.1747
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0044 0.017
Trypanosoma cruzi metacaspase 5, putative 0.002 0.0029 0.0037
Brugia malayi CXXC zinc finger family protein 0.0064 0.0205 0.0512
Plasmodium vivax unspecified product 0.0017 0.0018 0.0159
Trypanosoma brucei Metacaspase-4 0.002 0.0029 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0069 0.0224 0.0564
Plasmodium falciparum multidrug resistance protein 1 0.0024 0.0044 0.0215
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0111 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0403 0.0604
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0009 0.0012
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0044 0.017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0034 0.0132
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0015 0.0009 0.001
Schistosoma mansoni zinc finger protein 0.0032 0.0079 0.0119
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0208 0.0784 0.1978
Schistosoma mansoni follistatin 0.0086 0.0292 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0189
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.0029 0.02
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0015 0.0115
Entamoeba histolytica cysteine protease, putative 0.0027 0.0056 0.0218
Schistosoma mansoni lipoxygenase 0.025 0.0953 0.143
Echinococcus granulosus thyroid hormone receptor alpha 0.0032 0.0079 0.0119
Trypanosoma cruzi NAD+ synthase, putative 0.0092 0.0319 0.0424
Plasmodium falciparum enoyl-acyl carrier reductase 0.0208 0.0784 0.4331
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0014 0.0006 0.0007
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0089 0.0117
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0086 0.0292 0.2462
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0044 0.017
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0027 0.0057 0.0075
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0044 0.0044
Echinococcus multilocularis mitogen activated protein kinase 0.0113 0.0403 0.0403
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0033 0.0033
Trypanosoma cruzi target of rapamycin kinase 3 0.0021 0.0035 0.0046
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0014 0.0006 0.0006
Schistosoma mansoni cathepsin s 0.0017 0.0018 0.0027
Onchocerca volvulus 0.0064 0.0205 0.0512
Schistosoma mansoni caspase-3 (C14 family) 0.002 0.0029 0.0043
Loa Loa (eye worm) hypothetical protein 0.0035 0.0089 0.0214
Schistosoma mansoni hypothetical protein 0.0087 0.0297 0.0446
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0893 0.3534 0.4696
Echinococcus granulosus tar DNA binding protein 0.0071 0.0235 0.0352
Mycobacterium ulcerans glutaminase 0.0307 0.1182 0.299
Brugia malayi RNA binding protein 0.0071 0.0235 0.059
Brugia malayi Nuclear hormone receptor-like 1 0.0069 0.0224 0.0564
Echinococcus granulosus cathepsin l cysteine peptidase 0.0052 0.0157 0.0236
Brugia malayi tailless protein 0.0032 0.0079 0.0189
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0027 0.0057 0.0075
Loa Loa (eye worm) hypothetical protein 0.0331 0.1278 0.3276
Loa Loa (eye worm) hypothetical protein 0.0982 0.3891 1
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0021
Brugia malayi Cathepsin L-like precursor 0.0035 0.0089 0.0214
Leishmania major oxidoreductase-like protein 0.0014 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0046 0.0135 0.0333
Entamoeba histolytica cysteine protease, putative 0.0027 0.0056 0.0218
Brugia malayi Uncoordinated protein 44 0.0016 0.0014 0.0021
Echinococcus multilocularis lysine specific demethylase 5A 0.013 0.0472 0.0472
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0224 0.0337
Mycobacterium tuberculosis Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) 0.0092 0.0319 0.0798
Onchocerca volvulus 0.0125 0.0452 0.1149
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0036 0.0095 0.0229
Echinococcus granulosus arachidonate 5 lipoxygenase 0.025 0.0953 0.143
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0077 0.0257 0.0386
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0016 0.0058
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0044 0.017
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0044 0.017
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0086 0.0292 0.0738
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0034 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0069 0.0224 0.0564
Schistosoma mansoni hypothetical protein 0.0907 0.3589 0.5389
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0189
Trypanosoma cruzi cruzipain precursor, putative 0.0017 0.0018 0.0023
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0015 0.0009 0.001
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0089 0.0133
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0157 0.0614
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Brugia malayi cytochrome P450 0.0015 0.0009 0.001
Leishmania major p-glycoprotein 0.0024 0.0044 0.0058
Entamoeba histolytica cysteine protease, putative 0.0052 0.0157 0.0614
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0018 0.0023
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0046 0.0177
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0086 0.0295 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0056 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0057 0.0222
Brugia malayi chromobox protein homolog 3 0.0023 0.0043 0.0097
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0265 0.1014 0.1347
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0027 0.0057 0.0075
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0069 0.0224 0.0337
Trypanosoma brucei protein kinase, putative 0.0113 0.0403 0.0535
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0235 0.0352
Toxoplasma gondii ABC1 family protein 0.004 0.0111 0.0908
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0046 0.0046
Mycobacterium ulcerans NAD synthetase 0.0092 0.0319 0.0798
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0014 0.0051
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0015 0.0009 0.001
Brugia malayi jmjC domain containing protein 0.0035 0.0089 0.0214
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0235 0.0235
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0015 0.0009 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0035 0.0135
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.003 0.0206
Schistosoma mansoni hypothetical protein 0.0064 0.0206 0.031
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0125 0.0452 0.0452
Loa Loa (eye worm) jmjC domain-containing protein 0.0134 0.0487 0.1239
Loa Loa (eye worm) beta-lactamase 0.004 0.0111 0.0272
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0648 0.255 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0032 0.0079 0.0189
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0029 0.011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0069 0.0224 0.0564
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0024
Leishmania major hypothetical protein, conserved 0.004 0.0111 0.0147
Entamoeba histolytica hypothetical protein 0.0087 0.0297 0.1163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0057 0.0222
Giardia lamblia Kinase, CMGC MAPK 0.0113 0.0403 0.1385
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.1114 0.4365
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0265 0.1014 0.1347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.0026
Plasmodium falciparum LCCL domain-containing protein 0.0064 0.0206 0.1118
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0014 0.0006 0.0006
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0027 0.0057 0.0222
Brugia malayi Cathepsin L-like precursor 0.0017 0.0018 0.0032
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0089 0.0133
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0069 0.0224 0.0337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Entamoeba histolytica P-glycoprotein-1 0.0024 0.0044 0.017
Loa Loa (eye worm) nuclear factor I 0.0024 0.0047 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0024
Onchocerca volvulus Bile acid receptor homolog 0.0069 0.0224 0.0564
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0167 0.0414
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0113 0.0403 0.0534
Onchocerca volvulus 0.0982 0.3891 1
Leishmania major cathepsin L-like protease 0.0052 0.0157 0.0208
Onchocerca volvulus Glucosylceramidase homolog 0.019 0.0713 0.1821
Schistosoma mansoni nuclear receptor 0.0032 0.0079 0.0119
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0027 0.0056 0.0074
Brugia malayi Smad1 0.0044 0.0126 0.0311
Trichomonas vaginalis esterase, putative 0.004 0.0111 0.0434
Echinococcus multilocularis pol protein 0.2503 1 1
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0107 0.026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.034 0.051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0069 0.0224 0.0564
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0157 0.0614
Echinococcus multilocularis mitogen activated protein kinase 3 0.0113 0.0403 0.0403
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0044 0.017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0089 0.0134
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0115 0.0411 0.0411
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0056 0.0085
Loa Loa (eye worm) steroid hormone receptor 0.0069 0.0224 0.0564
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0025 0.0038
Loa Loa (eye worm) hypothetical protein 0.0125 0.0452 0.1149
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0044 0.017
Plasmodium vivax vivapain-2 0.0052 0.0157 0.1952
Loa Loa (eye worm) runx1 0.0123 0.0444 0.1127
Trichomonas vaginalis abcb9, putative 0.0024 0.0044 0.017
Brugia malayi ecdysone receptor 0.0032 0.0079 0.0189
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0089 0.0134
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0047
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0029 0.011
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0529 0.0794
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0032 0.0079 0.0119
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0029 0.011
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0017 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.034 0.051
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0037 0.0097 0.0097
Loa Loa (eye worm) glutaminase 2 0.0307 0.1182 0.3027
Onchocerca volvulus Cell death protein 3 homolog 0.0066 0.0215 0.0538
Entamoeba histolytica cysteine protease, putative 0.0027 0.0056 0.0218
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0044 0.017
Trypanosoma cruzi NAD+ synthase, putative 0.0092 0.0319 0.0424
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0069 0.0224 0.0337
Brugia malayi hypothetical protein 0.0032 0.0079 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.003 0.0113
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0111 0.0167
Trypanosoma brucei NAD+ synthase, putative 0.0092 0.0319 0.0424
Onchocerca volvulus 0.0064 0.0206 0.0517
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0157 0.0391
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0189
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0235 0.059
Brugia malayi MH2 domain containing protein 0.0648 0.2552 0.6555
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0014 0.0022
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.0079 0.0119
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.006
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0036 0.0095 0.0142
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0032 0.0079 0.0119
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0069 0.0224 0.0224
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0089 0.0214
Echinococcus granulosus chromobox protein 1 0.0042 0.0117 0.0176
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0044 0.0044
Plasmodium vivax vivapain-3 0.0027 0.0056 0.0653
Echinococcus granulosus mothers against decapentaplegic 6 0.002 0.0028 0.0042
Onchocerca volvulus Putative organic anion transporter 0.0125 0.0452 0.1149
Brugia malayi beta-lactamase 0.004 0.0111 0.0272
Loa Loa (eye worm) hypothetical protein 0.0125 0.0452 0.1149
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0089 0.0214
Toxoplasma gondii hypothetical protein 0.0304 0.1171 1
Brugia malayi sodium-independent organic anion transporter family protein 0.0125 0.0452 0.1149
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0015 0.0009 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0041 0.016
Brugia malayi hypothetical protein 0.0125 0.0452 0.1149
Toxoplasma gondii Alpha-galactosidase 0.0016 0.0014 0.0076
Schistosoma mansoni retinoic acid receptor RXR 0.0179 0.0669 0.1005
Schistosoma mansoni hypothetical protein 0.0186 0.0696 0.1045
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0015 0.0009 0.001
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0044 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0015 0.0009 0.001
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0107 0.0868
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0111 0.0167
Schistosoma mansoni smad1 5 8 and 0.0044 0.0126 0.019
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.002 0.0029 0.006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.003 0.0113
Echinococcus granulosus cathepsin l1 0.0035 0.0089 0.0133
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0046 0.0104
Schistosoma mansoni coup transcription factor 0.0069 0.0224 0.0337
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0015 0.0009 0.0012
Schistosoma mansoni smad 0.0044 0.0126 0.019
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0024 0.0044 0.0215
Onchocerca volvulus 0.0032 0.0079 0.0189
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0015 0.0009 0.001
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0461 0.1802 0.4567
Onchocerca volvulus 0.0052 0.0157 0.0391
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0056 0.0128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.034 0.051
Loa Loa (eye worm) hypothetical protein 0.0064 0.0206 0.0517
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0113 0.0403 0.0535
Trypanosoma cruzi metacaspase, putative 0.002 0.0029 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0743 0.0987
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0224 0.0337
Echinococcus granulosus smad 0.0044 0.0126 0.019
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0044 0.017
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0056 0.0128
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0015 0.0009 0.001
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0015 0.0009 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0648 0.255 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.013 0.0472 0.0709
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0052 0.0157 0.0845
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0089 0.0089
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0111 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.0026
Loa Loa (eye worm) DR-78 0.0032 0.0079 0.0189
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0056 0.0128
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0044 0.0066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0003 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0034 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.0754 0.2956
Brugia malayi hypothetical protein 0.0018 0.0022 0.0043
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0056 0.0131
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0157 0.0236
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0893 0.3534 0.4697
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0024
Echinococcus granulosus mitogen activated protein kinase 3 0.0113 0.0403 0.0604
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0095 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0024
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0157 0.0391
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0111 0.0269
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0069 0.0224 0.0224
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0086 0.0292 0.0738
Brugia malayi sodium-independent organic anion transporter family protein 0.0125 0.0452 0.1149
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0038 0.0103 0.0155
Brugia malayi nuclear hormone receptor 0.0069 0.0224 0.0564
Leishmania major cathepsin L-like protease 0.0198 0.0743 0.0987
Loa Loa (eye worm) multidrug resistance protein 3 0.0024 0.0044 0.0099
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0107 0.13
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0235 0.0352
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0069 0.0224 0.0564
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0044 0.017
Plasmodium vivax metacaspase 1, putative 0.002 0.0029 0.0299
Echinococcus granulosus cathepsin L 0.0027 0.0056 0.0085
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.006
Mycobacterium leprae conserved hypothetical protein 0.004 0.0111 0.0589
Schistosoma mansoni smdr2 0.0024 0.0044 0.0066
Onchocerca volvulus 0.0069 0.0224 0.0564
Entamoeba histolytica hypothetical protein 0.0087 0.0297 0.1163
Loa Loa (eye worm) heterochromatin protein 1 0.0042 0.0117 0.0287
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0069 0.0224 0.0564
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0157 0.0157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0648 0.255 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0032 0.0079 0.0079
Loa Loa (eye worm) CXXC zinc finger family protein 0.0064 0.0205 0.0512
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.029 0.1114 0.2852
Treponema pallidum fructose-bisphosphate aldolase 0.0648 0.255 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0437 0.1109
Loa Loa (eye worm) hypothetical protein 0.0186 0.0696 0.1776
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0743 0.0987
Brugia malayi hypothetical protein 0.0982 0.3891 1
Schistosoma mansoni transcription factor btf3 0.0039 0.0107 0.016
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0015 0.0009 0.001
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0044 0.017
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0208 0.0784 0.4331
Schistosoma mansoni smad 0.002 0.0028 0.0042
Echinococcus granulosus caspase 8 0.002 0.0029 0.0043
Entamoeba histolytica cysteine protease, putative 0.0027 0.0056 0.0218
Echinococcus multilocularis nuclear receptor nhr 48 0.0032 0.0079 0.0079
Brugia malayi beta-NAC-like protein 0.0039 0.0107 0.026
Brugia malayi prostaglandin transporter 0.0125 0.0452 0.1149
Toxoplasma gondii melibiase subfamily protein 0.0115 0.0411 0.3479
Schistosoma mansoni caspase-7 (C14 family) 0.002 0.0029 0.0043
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0009 0.0012
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0116 0.0116
Brugia malayi hypothetical protein 0.0064 0.0206 0.0517
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0015 0.0009 0.001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0032 0.0079 0.0119
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.003 0.0113
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0015 0.0023
Echinococcus granulosus Smad4 0.0044 0.0126 0.019
Loa Loa (eye worm) MH2 domain-containing protein 0.0044 0.0126 0.0311
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0056 0.0074
Entamoeba histolytica cysteine protease, putative 0.0027 0.0056 0.0218
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0063 0.0318
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0015 0.0009 0.001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0056 0.0128
Echinococcus multilocularis expressed protein 0.0086 0.0292 0.0292
Echinococcus granulosus Ankyrin 0.0016 0.0014 0.0022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0224 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0107 0.0415
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0089 0.0718
Schistosoma mansoni jumonji/arid domain-containing protein 0.0134 0.0487 0.0731
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0069 0.0224 0.0564
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0069 0.0224 0.0337
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0107 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0069 0.0224 0.0564
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0015 0.0009 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.002 0.0028 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.1114 0.4365
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0461 0.1802 1
Leishmania major cysteine peptidase A (CPA) 0.0052 0.0157 0.0208
Entamoeba histolytica cysteine protease, putative 0.0027 0.0056 0.0218
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0032 0.0079 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0069 0.0224 0.0564
Schistosoma mansoni thyroid hormone receptor 0.0144 0.0529 0.0794
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.003 0.0113
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.0029 0.02
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.0403 0.1576
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0009 0.0034
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0024 0.0044 0.0099
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1886 0.7525 1
Echinococcus multilocularis cathepsin L 0.0027 0.0056 0.0056
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0208 0.0784 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0044 0.017
Onchocerca volvulus Mothers against decapentaplegic homolog 0.002 0.0028 0.0059
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.002 0.0029 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0224 0.0224
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1886 0.7525 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0111 0.0269
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0044
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0014 0.0006 0.0006
Echinococcus granulosus microtubule associated protein 2 0.1671 0.666 1
Onchocerca volvulus 0.0042 0.0117 0.0286
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0069 0.0224 0.0564
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0265 0.1014 0.1348
Trichomonas vaginalis glucosylceramidase, putative 0.0201 0.0754 0.2956
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0235 0.0352
Schistosoma mansoni hypothetical protein 0.0054 0.0167 0.025
Plasmodium vivax multidomain scavenger receptor, putative 0.0064 0.0206 0.2582
Brugia malayi MH2 domain containing protein 0.002 0.0028 0.0059
Plasmodium falciparum metacaspase-like protein 0.002 0.0029 0.013
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0157 0.0614
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0069 0.0224 0.0564
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0089 0.0214
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0069 0.0224 0.0564
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0037 0.0097 0.0129
Loa Loa (eye worm) hypothetical protein 0.0266 0.1015 0.2599
Schistosoma mansoni cpg binding protein 0.0067 0.0219 0.0329
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0089 0.0344
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.1114 0.4365
Entamoeba histolytica cysteine protease, putative 0.0027 0.0056 0.0218
Brugia malayi MH1 domain containing protein 0.0024 0.0047 0.0107
Loa Loa (eye worm) hypothetical protein 0.0125 0.0452 0.1149
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0086 0.0292 0.2462
Echinococcus multilocularis transcription factor btf3 0.0039 0.0107 0.0107
Onchocerca volvulus 0.0027 0.0056 0.013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0032
Brugia malayi steroid hormone receptor 0.0069 0.0224 0.0564
Schistosoma mansoni survival motor neuron protein 0.0054 0.0167 0.025
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0069 0.0224 0.0564
Echinococcus multilocularis smad 0.0044 0.0126 0.0126
Loa Loa (eye worm) phosphatidylinositol 3 0.0027 0.0057 0.0133
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0024 0.0044 0.0058
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0015 0.0009 0.001
Brugia malayi jmjC domain containing protein 0.0134 0.0487 0.1239
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0029 0.011
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0089 0.0133
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0157 0.0157
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0713 0.2794
Leishmania major cathepsin L-like protease 0.0052 0.0157 0.0208
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.0089 0.0117
Loa Loa (eye worm) transcription factor SMAD2 0.0648 0.2552 0.6555
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0713 0.2794
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0014 0.0006 0.0006
Echinococcus granulosus bloom syndrome protein 0.0024 0.0046 0.0069
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0089 0.0133
Brugia malayi Cathepsin L-like precursor 0.0052 0.0157 0.0391
Loa Loa (eye worm) doublecortin family protein 0.0064 0.0206 0.0517
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0208 0.0784 0.1978
Entamoeba histolytica cysteine proteinase 1, putative 0.0027 0.0056 0.0218
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0044 0.017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0017 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.0026
Entamoeba histolytica P-glycoprotein-2, putative 0.0024 0.0044 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0016 0.0058
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0029 0.011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0034 0.0132
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0052 0.0157 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.0026
Brugia malayi hypothetical protein 0.0028 0.0063 0.0147
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0116 0.0174
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0032 0.0079 0.0189
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0116 0.045
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0057 0.0133
Schistosoma mansoni smad1 5 8 and 0.0044 0.0126 0.019
Schistosoma mansoni chromobox protein 0.0042 0.0117 0.0176
Trichomonas vaginalis chromobox protein, putative 0.0025 0.005 0.0194
Trypanosoma cruzi MFS transporter, putative 0.0125 0.0452 0.06
Brugia malayi Cathepsin L-like precursor 0.0052 0.0157 0.0391
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0136 0.0496 0.0745
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0015 0.0009 0.001
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0063 0.0318
Echinococcus granulosus lipoxygenase domain containing protein 0.0064 0.0206 0.031
Echinococcus granulosus muscleblind protein 0.0331 0.1278 0.192
Entamoeba histolytica P-glycoprotein-5 0.0024 0.0044 0.017
Schistosoma mansoni steroid hormone receptor ad4bp 0.0069 0.0224 0.0337
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0113 0.0403 0.1022
Entamoeba histolytica cysteine proteinase 2 0.0027 0.0056 0.0218
Brugia malayi cathepsin L-like precursor 0.0035 0.0089 0.0214
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0115 0.0411 0.0411
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0044 0.017
Schistosoma mansoni hypothetical protein 0.0086 0.0295 0.0442
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0063 0.0082
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0056 0.0281
Schistosoma mansoni hypothetical protein 0.0113 0.0403 0.0605
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0014 0.007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0052 0.0157 0.0391
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0017 0.0015 0.0057
Trichomonas vaginalis abcb9, putative 0.0024 0.0044 0.017
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0037 0.0097 0.0128
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0018 0.0032
Onchocerca volvulus Cathepsin F homolog 0.0052 0.0157 0.0391
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0098 0.0515
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0029 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0056 0.0075
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0015 0.0009 0.001
Echinococcus granulosus cysteine protease 0.0027 0.0056 0.0085
Brugia malayi Cathepsin L-like precursor 0.0035 0.0089 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0079 0.0119
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0111 0.0269
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0015 0.0009 0.001
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0032 0.0079 0.0079
Echinococcus granulosus nuclear receptor nhr 48 0.0032 0.0079 0.0119
Schistosoma mansoni transcription factor LCR-F1 0.0087 0.0297 0.0446
Leishmania major basic transcription factor 3a, putative 0.0039 0.0107 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.0026
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0084 0.0203
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0027 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0086 0.0292 0.0738
Echinococcus multilocularis FTZ F1 alpha 0.0069 0.0224 0.0224
Onchocerca volvulus Putative organic anion transporter 0.0125 0.0452 0.1149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0056 0.0128
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0116 0.0613
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0063 0.0082
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0015 0.0009 0.001
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0044 0.0126 0.0126
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0014 0.0021
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0044 0.0044
Schistosoma mansoni rab6-interacting 0.0064 0.0206 0.031
Loa Loa (eye worm) hypothetical protein 0.0069 0.0224 0.0564
Brugia malayi Death domain containing protein 0.0016 0.0014 0.0021
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0116 0.045
Loa Loa (eye worm) hypothetical protein 0.0036 0.0095 0.0229
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0025 0.0048
Echinococcus multilocularis cathepsin L cysteine protease 0.0052 0.0157 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.011
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.006
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0018 0.0032
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0063 0.049
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0111 0.0434
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0044 0.0066
Onchocerca volvulus 0.0125 0.0452 0.1149
Leishmania major cytochrome p450-like protein 0.0034 0.0084 0.0111
Schistosoma mansoni hypothetical protein 0.0086 0.0295 0.0442
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0056 0.0073
Schistosoma mansoni hypothetical protein 0.0086 0.0295 0.0442
Schistosoma mansoni lipoxygenase 0.0135 0.0489 0.0735
Brugia malayi MH1 domain containing protein 0.0044 0.0126 0.0311
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0044 0.017
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0021 0.0035 0.0047
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0069 0.0224 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0014 0.0051
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0017 0.0026
Loa Loa (eye worm) Smad1 0.0044 0.0126 0.0311
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0079 0.0119
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0063 0.0735
Schistosoma mansoni hypothetical protein 0.0076 0.0254 0.0381
Echinococcus granulosus caspase 2 0.0066 0.0215 0.0322
Echinococcus multilocularis mothers against decapentaplegic 5 0.0044 0.0126 0.0126
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0014 0.0006 0.0008
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.0092 0.0319 0.4034
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0461 0.1802 0.6646
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0044 0.017
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.0403 0.1576
Onchocerca volvulus 0.004 0.0111 0.0272
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0014 0.0006 0.0006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0086 0.0295 0.0744
Giardia lamblia NH3-dependent NAD+ synthetase 0.0092 0.0319 0.1051
Trypanosoma brucei metacaspase MCA3 0.002 0.0029 0.0038
Schistosoma mansoni multidrug resistance protein 0.0024 0.0044 0.0066
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0125 0.0452 0.1149
Toxoplasma gondii transporter, major facilitator family protein 0.0125 0.0452 0.3831
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0111 0.0111
Brugia malayi MH1 domain containing protein 0.0044 0.0126 0.0311
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0116 0.028
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0056 0.0128
Brugia malayi MH2 domain containing protein 0.0044 0.0126 0.0311
Brugia malayi glutaminase DH11.1 0.0307 0.1182 0.3027
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0084 0.0203
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0014 0.0006 0.0019
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.013 0.0472 0.0472
Echinococcus multilocularis mothers against decapentaplegic 2 0.002 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0157 0.0614
Loa Loa (eye worm) hypothetical protein 0.0064 0.0206 0.0517
Onchocerca volvulus 0.0024 0.0044 0.0099
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0056 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0743 0.0987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0057 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0713 0.2794
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0036 0.0095 0.0095
Echinococcus multilocularis ATP binding cassette sub family B 0.0023 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0037 0.0097 0.0236
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0036 0.0095 0.0142
Brugia malayi Cathepsin L-like precursor 0.0052 0.0157 0.0391
Leishmania major cathepsin L-like protease 0.0052 0.0157 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0743 0.0987
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0116 0.045
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0086 0.0295 0.0442
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0023 0.0043 0.0097
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0052 0.0157 0.0845
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0089 0.0133
Leishmania major mitochondrial DNA polymerase beta 0.1886 0.7525 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0013 0.0048
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0027 0.0057 0.0086
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.004 0.0111 0.0272
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0014 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.013
Loa Loa (eye worm) hypothetical protein 0.004 0.0111 0.0272
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.034 0.086
Brugia malayi nuclear hormone receptor 0.0032 0.0079 0.0189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0043 0.0166
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0032 0.0079 0.0189
Plasmodium vivax hypothetical protein, conserved 0.002 0.0029 0.0299
Loa Loa (eye worm) hypothetical protein 0.0086 0.0292 0.0738
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.011
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0084 0.02
Schistosoma mansoni nuclear receptor nhr-48 0.0032 0.0079 0.0119
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0044 0.0066
Onchocerca volvulus 0.004 0.0111 0.0272
Onchocerca volvulus 0.0052 0.0157 0.0391
Trypanosoma cruzi cysteine protease, putative 0.0027 0.0056 0.0074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.034 0.034
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0056 0.0218
Entamoeba histolytica cysteine protease, putative 0.0027 0.0056 0.0218
Loa Loa (eye worm) hypothetical protein 0.0036 0.0095 0.0229
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0084 0.0112
Onchocerca volvulus 0.0052 0.0157 0.0391
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0015 0.0009 0.001
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0056 0.013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0069 0.0224 0.0564
Mycobacterium leprae Probable lipase LipE 0.004 0.0111 0.0589
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0111 0.0272
Echinococcus multilocularis Polycystic kidney disease protein 0.0064 0.0206 0.0206
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0461 0.1802 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.011
Schistosoma mansoni Smad4 0.002 0.0028 0.0042
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0029 0.0059
Brugia malayi nuclear receptor NHR-67 0.0032 0.0079 0.0189
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0059
Brugia malayi ecdysteroid receptor 0.0069 0.0224 0.0564
Entamoeba histolytica hypothetical protein 0.0087 0.0297 0.1163
Entamoeba histolytica P-glycoprotein 5, putative 0.0024 0.0044 0.017
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0125 0.0452 0.0679
Echinococcus granulosus cathepsin L cysteine protease 0.0027 0.0056 0.0085
Schistosoma mansoni jumonji/arid domain-containing protein 0.0134 0.0487 0.0731
Brugia malayi Steroid receptor seven-up type 2 0.0069 0.0224 0.0564
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0034 0.0132
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0044 0.017
Loa Loa (eye worm) hypothetical protein 0.0982 0.3891 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0024
Mycobacterium ulcerans GMP synthase 0.0037 0.0097 0.0233
Schistosoma mansoni jumonji domain containing protein 0.013 0.0472 0.0709
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0056 0.0131
Brugia malayi hypothetical protein 0.0036 0.0095 0.0229
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0648 0.255 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0116 0.0153
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0095 0.0229
Leishmania major hypothetical protein, conserved 0.0028 0.0063 0.0082
Schistosoma mansoni multidrug resistance protein 0.0024 0.0044 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0014 0.0051
Brugia malayi Cathepsin L-like cysteine proteinase 0.0035 0.0089 0.0214
Echinococcus granulosus FTZ F1 alpha 0.0069 0.0224 0.0337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Schistosoma mansoni smad1 5 8 and 0.0044 0.0126 0.019
Schistosoma mansoni cpg binding protein 0.0064 0.0205 0.0307
Loa Loa (eye worm) hypothetical protein 0.0035 0.0089 0.0214
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0016 0.0014 0.0022
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0024 0.0044 0.0331
Echinococcus granulosus RUN 0.0064 0.0206 0.031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0157 0.0614
Echinococcus granulosus follistatin 0.0086 0.0292 0.0439
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0097
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0089 0.0089
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0116 0.0153
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0044 0.0044
Brugia malayi Cathepsin L-like precursor 0.0052 0.0157 0.0391
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0069 0.0224 0.0337
Brugia malayi hypothetical protein 0.0266 0.1015 0.2599
Entamoeba histolytica cysteine protease, putative 0.0027 0.0056 0.0218
Echinococcus granulosus agrin 0.0086 0.0292 0.0439
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0087 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0069 0.0224 0.0564
Echinococcus multilocularis 0.0015 0.0009 0.0009
Echinococcus granulosus Polycystic kidney disease protein 0.0064 0.0206 0.031
Mycobacterium tuberculosis Conserved protein 0.004 0.0111 0.0269
Plasmodium vivax JmjC domain containing protein 0.0035 0.0089 0.1068
Giardia lamblia Fructose-bisphosphate aldolase 0.0648 0.255 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0015 0.0009 0.001
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0015 0.0009 0.001
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0125 0.0452 0.0452
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0044 0.0044
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0033 0.0071
Loa Loa (eye worm) hypothetical protein 0.0035 0.0089 0.0214
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0272 0.1041 0.2666
Trypanosoma cruzi metacaspase, putative 0.002 0.0029 0.0037
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0014 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0111 0.0147
Toxoplasma gondii histone lysine methyltransferase SET1 0.0122 0.0438 0.3713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.0026
Loa Loa (eye worm) agrin synaptic family protein 0.0086 0.0292 0.0738
Trypanosoma cruzi metacaspase, putative 0.002 0.0029 0.0037
Echinococcus multilocularis follistatin 0.0086 0.0292 0.0292
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0208 0.0784 0.6676
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.0403 0.1576
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0069 0.0224 0.0337
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0056 0.0218
Brugia malayi sodium-independent organic anion transporter family protein 0.0125 0.0452 0.1149
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0208 0.0784 0.4331
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0316 0.122 0.3086
Trichomonas vaginalis taga, putative 0.0024 0.0044 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0089 0.0344
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.0092 0.0319 0.2694
Mycobacterium ulcerans beta-lactamase 0.004 0.0111 0.0269
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0235 0.059
Leishmania major cathepsin L-like protease 0.0198 0.0743 0.0987
Schistosoma mansoni glutaminase 0.0307 0.1182 0.1774
Leishmania major cathepsin L-like protease 0.0052 0.0157 0.0208
Plasmodium falciparum JmjC domain-containing protein, putative 0.0035 0.0089 0.0462
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0235 0.059
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0023
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0027 0.0057 0.0222
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0157 0.0614
Schistosoma mansoni loxhd1 0.0064 0.0206 0.031
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0069 0.0224 0.0564
Loa Loa (eye worm) hypothetical protein 0.0272 0.1041 0.2666
Brugia malayi Cell death protein 3 precursor 0.0066 0.0215 0.0538
Echinococcus multilocularis apoptotic protease activating factor 1 0.0046 0.0135 0.0135
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0015 0.0009 0.001
Onchocerca volvulus 0.0052 0.0157 0.0391
Loa Loa (eye worm) nuclear receptor NHR-67 0.0032 0.0079 0.0189
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0044 0.017
Toxoplasma gondii cathepsin CPL 0.0052 0.0157 0.1303
Brugia malayi Cathepsin L-like precursor 0.0052 0.0157 0.0391
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.034 0.051
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0111 0.0434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0035 0.0135
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0015 0.0009 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.034 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0035 0.0135
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0181 0.0674 0.0895
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0648 0.255 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0648 0.255 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0056 0.0216
Mycobacterium ulcerans hypothetical protein 0.0027 0.0056 0.0128
Brugia malayi Cytochrome P450 family protein 0.0034 0.0084 0.0203
Schistosoma mansoni cathepsin F (C01 family) 0.0052 0.0157 0.0236
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0143 0.0524 0.0524
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0044 0.0126 0.019
Loa Loa (eye worm) hypothetical protein 0.0069 0.0224 0.0564
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0116 0.0944
Mycobacterium leprae PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) 0.0092 0.0319 0.1747
Loa Loa (eye worm) hypothetical protein 0.0036 0.0095 0.0229
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0032 0.0079 0.0079
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.1114 0.4365
Brugia malayi Inositol-1 0.0041 0.0116 0.0283
Schistosoma mansoni Smad4 0.002 0.0028 0.0042
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0648 0.255 1
Brugia malayi secreted modular calcium-binding protein 1 0.0086 0.0292 0.0738
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0077 0.0257 0.0386
Brugia malayi hypothetical protein 0.0125 0.0452 0.1149
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0116 0.0153
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0113 0.0403 0.0534
Echinococcus granulosus phd:f box containing protein 0.0035 0.0089 0.0133
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0111 0.0269
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.002 0.0029 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0015 0.0009 0.001
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0316 0.122 0.6759
Trypanosoma cruzi metacaspase 5, putative 0.002 0.0029 0.0037
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0086 0.0292 0.0738
Loa Loa (eye worm) MH1 domain-containing protein 0.0044 0.0126 0.0311
Echinococcus granulosus Solute carrier organic anion transporter family 0.0125 0.0452 0.0679
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0113 0.0403 0.0534
Mycobacterium ulcerans lipase LipD 0.004 0.0111 0.0269
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0015 0.0009 0.001
Echinococcus granulosus cathepsin L cysteine proteinase 0.0052 0.0157 0.0236
Schistosoma mansoni nuclear receptor 0.0032 0.0079 0.0119
Entamoeba histolytica cysteine protease, putative 0.0027 0.0056 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0007 0.0024
Onchocerca volvulus 0.0064 0.0206 0.0517
Trichomonas vaginalis abcb9, putative 0.0024 0.0044 0.017
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0044 0.017
Brugia malayi Pre-SET motif family protein 0.0035 0.0089 0.0215
Echinococcus multilocularis caspase 2 0.0066 0.0215 0.0215
Echinococcus multilocularis muscleblind protein 1 0.0331 0.1278 0.1278
Echinococcus granulosus cpg binding protein 0.0067 0.0219 0.0329
Loa Loa (eye worm) hypothetical protein 0.004 0.0111 0.0272
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.0044 0.017
Schistosoma mansoni inositol monophosphatase 0.0041 0.0116 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0107 0.0415
Brugia malayi nuclear receptor NHR-88 0.0032 0.0079 0.0189
Loa Loa (eye worm) hypothetical protein 0.0125 0.0452 0.1149
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0157 0.0614
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0001 0.0001
Schistosoma mansoni netrin receptor unc5 0.0016 0.0014 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.011
Echinococcus multilocularis dnaJ subfamily B 0.0907 0.3589 0.3589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0035 0.0135
Entamoeba histolytica cysteine protease, putative 0.0027 0.0056 0.0218
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0044 0.0066
Echinococcus granulosus transcription factor btf3 0.0039 0.0107 0.016
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0086 0.0292 0.0738
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0037 0.0097 0.0786
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0024 0.0044 0.0098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0648 0.255 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0021 0.0035 0.0046
Plasmodium vivax vivapain-2 0.0052 0.0157 0.1952
Leishmania major cathepsin L-like protease 0.0198 0.0743 0.0987
Trichomonas vaginalis set domain proteins, putative 0.0267 0.1023 0.4009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0272 0.1041 0.2666
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0015 0.0009 0.001
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0115 0.0411 0.0617
Loa Loa (eye worm) fibroinase 0.0052 0.0157 0.0391
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0044 0.0066
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0113 0.0403 0.0534
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0029 0.011
Echinococcus multilocularis cysteine protease 0.0052 0.0157 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0107 0.0415
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0086 0.0292 0.2462
Entamoeba histolytica cysteine protease, putative 0.0027 0.0056 0.0218
Leishmania major pteridine reductase 1 0.0014 0.0006 0.0006
Echinococcus multilocularis caspase 8 0.002 0.0029 0.0029
Brugia malayi jmjC domain containing protein 0.0035 0.0089 0.0214
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0056 0.0281
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0056 0.0128
Brugia malayi Nuclear hormone receptor E75 0.0032 0.0079 0.0189
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0189
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0069 0.0224 0.0337
Loa Loa (eye worm) glutaminase 0.0307 0.1182 0.3027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.0529 0.0529
Echinococcus granulosus nuclear factor of activated T cells 5 0.0083 0.0281 0.0422
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0157 0.0391
Brugia malayi Melibiase family protein 0.0077 0.0257 0.0647
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.0032
Loa Loa (eye worm) hypothetical protein 0.0125 0.0452 0.1149
Echinococcus multilocularis mothers against decapentaplegic 6 0.002 0.0028 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0713 0.2794
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0107 0.0141
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0015 0.0009 0.001
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0083 0.0281 0.0281
Schistosoma mansoni GMP synthetase 0.0037 0.0097 0.0146
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0015 0.0009 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Schistosoma mansoni hypothetical protein 0.0046 0.0135 0.0202
Plasmodium falciparum cysteine proteinase falcipain 1 0.0027 0.0056 0.0283
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0086 0.0292 0.2462
Echinococcus multilocularis microtubule associated protein 2 0.1671 0.666 0.666
Onchocerca volvulus 0.0018 0.0023 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0648 0.255 1
Echinococcus multilocularis Smad4 0.0044 0.0126 0.0126
Mycobacterium leprae putative cytochrome p450 0.0015 0.0009 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0052 0.0157 0.0614
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0111 0.0269
Loa Loa (eye worm) hypothetical protein 0.0036 0.0095 0.0229
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0089 0.0133
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0056 0.0074
Mycobacterium ulcerans hypothetical protein 0.004 0.0111 0.0269
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0025 0.0048
Trypanosoma brucei metacaspase 5, putative 0.002 0.0029 0.0038
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0035 0.0089 0.0713
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.006
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0056 0.0128
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0014 0.0014
Echinococcus granulosus cathepsin l1 0.0052 0.0157 0.0236
Echinococcus multilocularis cpg binding protein 0.0067 0.0219 0.0219
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0157 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0043 0.0166
Entamoeba histolytica P-glycoprotein-2 0.0024 0.0044 0.017
Echinococcus granulosus lysine specific demethylase 5A 0.0134 0.0487 0.0731
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0316 0.122 0.3086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0013 0.0048
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0116 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0022 0.0082
Loa Loa (eye worm) hypothetical protein 0.004 0.0111 0.0272
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.0015 0.0015
Trypanosoma cruzi major cysteine proteinase, putative 0.0155 0.0573 0.0761
Onchocerca volvulus 0.0086 0.0292 0.0738
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0056 0.0216
Schistosoma mansoni cpg binding protein 0.0067 0.0219 0.0329
Brugia malayi nuclear receptor RXR 0.0032 0.0079 0.0189
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0115 0.0411 0.0617
Schistosoma mansoni caspase-7 (C14 family) 0.0066 0.0215 0.0322
Brugia malayi jmjC domain containing protein 0.0035 0.0089 0.0214
Loa Loa (eye worm) hypothetical protein 0.004 0.0111 0.0272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0056 0.0075
Trypanosoma cruzi cysteine peptidase, putative 0.0198 0.0743 0.0987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.0026
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0056 0.0216
Entamoeba histolytica P-glycoprotein-2 0.0024 0.0044 0.017
Loa Loa (eye worm) hypothetical protein 0.0077 0.0257 0.0647
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0189
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0063 0.0083
Echinococcus multilocularis muscleblind protein 0.0331 0.1278 0.1278
Brugia malayi Latrophilin receptor protein 2 0.0086 0.0295 0.0744
Echinococcus multilocularis survival motor neuron protein 1 0.0266 0.1015 0.1015
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0056 0.0128
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.1114 0.4365
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0027 0.0057 0.0076
Loa Loa (eye worm) hypothetical protein 0.0069 0.0224 0.0564
Brugia malayi nuclear receptor NHR-88 0.0069 0.0224 0.0564
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0117 0.0175
Brugia malayi Heterochromatin protein 1 0.0042 0.0117 0.0287
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0258 0.0986 0.2493
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0743 0.0987
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.003 0.0113
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0009 0.0012
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0014 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0157 0.0614
Echinococcus granulosus apoptotic protease activating factor 1 0.0046 0.0135 0.0202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0743 0.0987
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.013
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0027 0.0057 0.0086
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.029 0.1114 0.2852
Trypanosoma brucei metacaspase MCA2 0.002 0.0029 0.0038
Schistosoma mansoni nuclear hormone receptor 0.0069 0.0224 0.0337
Echinococcus multilocularis chromobox protein 1 0.0042 0.0117 0.0117
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0089 0.0089
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0089 0.0134
Trypanosoma brucei oxidoreductase-like protein 0.0014 0.0006 0.0007
Brugia malayi jmjC domain containing protein 0.013 0.0472 0.1202
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.003 0.0113
Plasmodium vivax vivapain-1 0.0027 0.0056 0.0653
Brugia malayi mothers against decapentaplegic homolog 3 0.002 0.0028 0.0059
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0179 0.0669 0.1005
Trichomonas vaginalis chromobox protein, putative 0.0025 0.005 0.0194
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.0089 0.0713
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0111 0.0269
Brugia malayi hypothetical protein 0.0036 0.0095 0.0229
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.0107 0.0563
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0015 0.0009 0.001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0069 0.0224 0.0564
Schistosoma mansoni multidrug resistance protein 0.0024 0.0044 0.0066
Echinococcus granulosus mitogen activated protein kinase 0.0113 0.0403 0.0604
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0089 0.0134
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0015 0.0009 0.001
Entamoeba histolytica hypothetical protein 0.0039 0.0107 0.0415
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0235 0.0352
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0095 0.0229
Trypanosoma cruzi cruzipain precursor, putative 0.0198 0.0743 0.0987
Brugia malayi Muscleblind-like protein 0.0331 0.1278 0.3276
Loa Loa (eye worm) hypothetical protein 0.0069 0.0224 0.0564
Schistosoma mansoni hypothetical protein 0.019 0.0713 0.1071
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0055 0.0171 0.0257
Trichomonas vaginalis CMGC family protein kinase 0.0113 0.0403 0.1576
Echinococcus multilocularis agrin 0.0086 0.0292 0.0292
Onchocerca volvulus 0.0268 0.1023 0.262
Echinococcus multilocularis caspase 0.002 0.0029 0.0029
Trichomonas vaginalis glutaminase, putative 0.0307 0.1182 0.4633
Onchocerca volvulus 0.0046 0.0135 0.0333
Brugia malayi SPARC precursor 0.0086 0.0292 0.0738
Loa Loa (eye worm) hypothetical protein 0.0028 0.0063 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0743 0.0987
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.002 0.0029 0.0043
Plasmodium vivax hypothetical protein, conserved 0.004 0.0111 0.1361
Loa Loa (eye worm) nuclear hormone receptor 0.0032 0.0079 0.0189
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0189
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0743 0.0987
Schistosoma mansoni dihydropteridine reductase 0.0014 0.0006 0.0008
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0014 0.0006 0.0006
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0044 0.0066
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0009 0.0014
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0461 0.1802 0.4567
Brugia malayi Cytochrome P450 family protein 0.0034 0.0084 0.0203
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0089 0.0133
Loa Loa (eye worm) hypothetical protein 0.0069 0.0224 0.0564
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0056 0.0085
Schistosoma mansoni lozenge 0.0123 0.0444 0.0666
Brugia malayi hypothetical protein 0.0032 0.0079 0.0189
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1886 0.7525 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0069 0.0224 0.0337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0157 0.0614
Echinococcus granulosus chromobox protein 1 0.0042 0.0117 0.0176
Loa Loa (eye worm) hypothetical protein 0.0125 0.0452 0.1149
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0173 0.043
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0029 0.011
Schistosoma mansoni organic anion transporter 0.0125 0.0452 0.0679
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0056 0.0085
Brugia malayi beta-lactamase family protein 0.004 0.0111 0.0272
Loa Loa (eye worm) hypothetical protein 0.004 0.0111 0.0272
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0893 0.3534 0.4696
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0743 0.0987
Plasmodium vivax unspecified product 0.0027 0.0056 0.0653
Brugia malayi conserved hypotetical protein 0.0032 0.0079 0.0189
Brugia malayi MAP kinase sur-1 0.0113 0.0403 0.1022
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0117 0.0456
Loa Loa (eye worm) hypothetical protein 0.0125 0.0452 0.1149
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0025 0.0048
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0076 0.0254 0.0381
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0115 0.0411 0.0617
Brugia malayi jmjC domain containing protein 0.0035 0.0089 0.0214
Brugia malayi multidrug resistance protein 3 0.0024 0.0044 0.0099
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0015 0.0009 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0087 0.0297 0.0446
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.0713 0.2794
Schistosoma mansoni hypothetical protein 0.019 0.0713 0.1071
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0189
Schistosoma mansoni cytochrome P450 0.0015 0.0009 0.0014
Onchocerca volvulus 0.0032 0.0079 0.0189
Brugia malayi MH2 domain containing protein 0.0044 0.0126 0.0311
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0092 0.0319 0.048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0089 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0079 0.0079
Trypanosoma brucei RNA helicase, putative 0.0113 0.0403 0.0535
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0117 0.0456
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0111 0.0434
Schistosoma mansoni rab6-interacting 0.0064 0.0206 0.031
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0044 0.0066
Echinococcus multilocularis Ankyrin 0.0016 0.0014 0.0014
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0157 0.0391
Entamoeba histolytica hypothetical protein 0.0087 0.0297 0.1163
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.1114 0.4365
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0017 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0743 0.0987
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.002 0.0029 0.02
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0198 0.0743 0.0987
Entamoeba histolytica P-glyco protein 6, putative 0.0024 0.0044 0.017
Loa Loa (eye worm) hypothetical protein 0.0086 0.0295 0.0744
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0111 0.0434
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0021
Leishmania major cytochrome p450-like protein 0.0015 0.0009 0.0012
Brugia malayi hypothetical protein 0.0087 0.0297 0.0751
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0056 0.013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0272 0.1041 0.2666
Loa Loa (eye worm) hypothetical protein 0.0035 0.0089 0.0214
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0032 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0073
Entamoeba histolytica NAD synthetase, putative 0.0092 0.0319 0.125
Brugia malayi Doublecortin family protein 0.0064 0.0206 0.0517
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0069 0.0224 0.0564
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.0044 0.017
Schistosoma mansoni hypothetical protein 0.0015 0.0009 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0069 0.0224 0.0564
Schistosoma mansoni chromobox protein 0.0042 0.0117 0.0176
Echinococcus multilocularis geminin 0.019 0.0713 0.0713
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.025 0.0953 0.0953
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0025 0.005 0.0115
Mycobacterium ulcerans hypothetical protein 0.0994 0.3939 1
Onchocerca volvulus 0.0125 0.0452 0.1149
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0086 0.0292 0.0738
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0034 0.0132
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.006
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0235 0.0352
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0113 0.0403 0.3407
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0069 0.0224 0.0337
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0015 0.0009 0.001
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0029 0.011
Mycobacterium tuberculosis Conserved protein 0.004 0.0111 0.0269
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0037 0.0097 0.0146
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0037 0.0097 0.051
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0033 0.005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0095 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0111 0.0147
Echinococcus granulosus GPCR family 2 0.0086 0.0295 0.0442
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0027 0.0057 0.0075
Brugia malayi ABC transporter family protein 0.0024 0.0044 0.0099
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.002 0.0029 0.011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0157 0.0614
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0014 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0111 0.0434
Entamoeba histolytica cysteine proteinase, putative 0.0052 0.0157 0.0614
Schistosoma mansoni organic anion transporter 0.0125 0.0452 0.0679
Brugia malayi Pre-SET motif family protein 0.0235 0.0893 0.2284
Loa Loa (eye worm) hypothetical protein 0.0035 0.0089 0.0215
Brugia malayi nuclear receptor RXR 0.0036 0.0095 0.0229
Mycobacterium leprae Conserved hypothetical protein 0.0015 0.0009 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0079 0.0189
Leishmania major metacaspase, putative 0.002 0.0029 0.0037
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0086 0.0292 0.0738
Brugia malayi orphan nuclear receptor NR2E1 0.0032 0.0079 0.0189
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0069 0.0224 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.011
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0323 0.1247 0.1657
Trypanosoma cruzi cysteine peptidase, putative 0.0198 0.0743 0.0987
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0077 0.0257 0.1005
Loa Loa (eye worm) RNA binding protein 0.0071 0.0235 0.059
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0111 0.0269
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0015 0.0023
Leishmania major hypothetical protein, conserved 0.0035 0.0089 0.0117
Brugia malayi nuclear hormone receptor family member nhr-6 0.0032 0.0079 0.0189
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0089 0.0117
Loa Loa (eye worm) cytochrome P450 0.0015 0.0009 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0111 0.0272
Leishmania major NAD synthase, putative 0.0092 0.0319 0.0424
Onchocerca volvulus 0.0052 0.0157 0.0391
Echinococcus granulosus mothers against decapentaplegic 2 0.002 0.0028 0.0042
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0014 0.0006 0.0008
Schistosoma mansoni hypothetical protein 0.0086 0.0295 0.0442
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0157 0.0614
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0015 0.0009 0.001
Brugia malayi nuclear hormone receptor family member odr-7 0.0032 0.0079 0.0189
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0086 0.0295 0.0442
Echinococcus multilocularis GPCR, family 2 0.0086 0.0295 0.0295
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0113 0.0403 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0069 0.0224 0.0564
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0097
Echinococcus multilocularis lipoxygenase domain containing protein 0.0064 0.0206 0.0206
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0044 0.017
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0089 0.0344
Onchocerca volvulus Protein ultraspiracle homolog 0.0069 0.0224 0.0564
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.0092 0.0319 0.125
Brugia malayi hypothetical protein 0.0064 0.0206 0.0517

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 15 mg kg-1 Anticonvulsant activity in mouse maximal electroshock assay following i.p. administration. ChEMBL. 7205879
ND50 (functional) = 33 mg kg-1 Dose causing a neurological deficit in 50% of mice after ip administration. ChEMBL. 7205879
PI (functional) = 2.2 Protective index of the compound is defined as ND50 (i.p.) divided by MES ED50(i.p.) ChEMBL. 7205879

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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