Detailed information for compound 1284192

Basic information

Technical information
  • TDR Targets ID: 1284192
  • Name: 6159-99-5
  • MW: 455.673 | Formula: C29H45NO3
  • H donors: 1 H acceptors: 1 LogP: 5.96 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCC2(NC1)OC1C(C2C)C2(C(C1)C1CC=C3C(C1CC2)(C)CCC(C3)OC(=O)C)C
  • InChi: 1S/C29H45NO3/c1-17-8-13-29(30-16-17)18(2)26-25(33-29)15-24-22-7-6-20-14-21(32-19(3)31)9-11-27(20,4)23(22)10-12-28(24,26)5/h6,17-18,21-26,30H,7-16H2,1-5H3
  • InChiKey: MCQNPWNREVNWDQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • Acetylsolasodine
  • NSC96021
  • Solasod-5-en-3.beta.-ol, acetate (ester)
  • Solasodine, acetate (ester)
  • Spirosol-5-en-3-ol, acetate (ester), (3.beta.,22.alpha.,25R)-
  • MLS000736975
  • SMR000528449
  • spirosol-5-en-3-yl acetate
  • NCI60_042142

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0013 0.0028
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.0511 0.1716
Plasmodium falciparum importin beta, putative 0.0031 0.0035 0.0259
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0044 0.0071 0.0495
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0044 0.0071 0.0197
Schistosoma mansoni hypothetical protein 0.0926 0.2721 0.5874
Brugia malayi hypothetical protein 0.0047 0.008 0.027
Echinococcus granulosus Polycystic kidney disease protein 0.0045 0.0074 0.0159
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.0551 0.0551
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0073
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0021 0.0046
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.0012 0.0039
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0012 0.0039
Loa Loa (eye worm) hypothetical protein 0.0126 0.0318 0.1078
Schistosoma mansoni hypothetical protein 0.0033 0.0039 0.0083
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0043
Loa Loa (eye worm) hypothetical protein 0.0045 0.0074 0.025
Loa Loa (eye worm) CXXC zinc finger family protein 0.0093 0.0219 0.074
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0163 0.0429 0.0925
Brugia malayi CXXC zinc finger family protein 0.0093 0.0219 0.074
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0067 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0156 0.0565
Loa Loa (eye worm) hypothetical protein 0.0083 0.019 0.0643
Echinococcus granulosus phd:f box containing protein 0.0036 0.0047 0.0101
Trypanosoma brucei hypothetical protein, conserved 0.019 0.0511 0.1846
Entamoeba histolytica hypothetical protein 0.0077 0.0172 0.0839
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0133 0.034 0.034
Leishmania major cytochrome p450-like protein 0.0044 0.0071 0.0256
Echinococcus granulosus muscleblind protein 0.0338 0.0956 0.2063
Brugia malayi GMP synthase 0.0037 0.0051 0.0174
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0012 0.0025
Echinococcus multilocularis agrin 0.0086 0.0198 0.0198
Giardia lamblia Kinase, CMGC MAPK 0.0115 0.0286 0.0397
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0662 0.1927 0.6475
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0209 0.0568 0.4167
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0013 0.0043
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0065 0.0236
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0012 0.0039
Mycobacterium ulcerans hypothetical protein 0.0496 0.1429 1
Echinococcus granulosus lysine specific demethylase 6a 0.0036 0.0047 0.0101
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0045 0.0153
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0156 0.0565
Loa Loa (eye worm) hypothetical protein 0.0267 0.0742 0.2514
Schistosoma mansoni jumonji/arid domain-containing protein 0.0141 0.0363 0.0783
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0012 0.0039
Brugia malayi hypothetical protein 0.0024 0.0013 0.0043
Echinococcus multilocularis microtubule associated protein 2 0.1563 0.4632 0.4632
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0039 0.0131
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.002 0.0057
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0167 0.036
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0044 0.0071 0.0495
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0094 0.0319
Trichomonas vaginalis esterase, putative 0.019 0.0511 0.1716
Schistosoma mansoni jumonji domain containing protein 0.0133 0.034 0.0734
Brugia malayi Bromodomain containing protein 0.0045 0.0075 0.0255
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0044 0.0071 0.0495
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0116 0.0116
Trypanosoma cruzi cytochrome P450, putative 0.0071 0.0153 0.0555
Toxoplasma gondii histone lysine methyltransferase SET1 0.0183 0.049 0.8636
Plasmodium falciparum LCCL domain-containing protein 0.0045 0.0074 0.0553
Schistosoma mansoni coup transcription factor 0.0051 0.0094 0.0203
Trichomonas vaginalis set domain proteins, putative 0.1011 0.2977 1
Trypanosoma brucei protein kinase, putative 0.0115 0.0286 0.1035
Brugia malayi SPARC precursor 0.0086 0.0198 0.0672
Loa Loa (eye worm) hypothetical protein 0.0338 0.0956 0.3238
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0196 0.0527 0.0527
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.0551 0.1189
Schistosoma mansoni cpg binding protein 0.01 0.0241 0.0521
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0012 0.0012
Schistosoma mansoni glutaminase 0.0309 0.0867 0.1872
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0209 0.0568 1
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0044 0.0071 0.0197
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.011 0.0398
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0086 0.0198 0.0672
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.0287 0.062
Loa Loa (eye worm) cytochrome P450 family protein 0.0071 0.0153 0.052
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0013 0.0043
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0086 0.0198 0.3493
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0045 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0094 0.0319
Schistosoma mansoni hypothetical protein 0.0336 0.0949 0.205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0156 0.0565
Brugia malayi jmjC domain containing protein 0.0036 0.0047 0.0158
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0065 0.0236
Loa Loa (eye worm) glutaminase 2 0.0309 0.0867 0.2938
Brugia malayi Cytochrome P450 family protein 0.0071 0.0153 0.052
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0116 0.0287 0.062
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0012 0.0025
Brugia malayi RNA binding protein 0.0072 0.0155 0.0525
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0156 0.0565
Schistosoma mansoni follistatin 0.0086 0.0198 0.0428
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.019 0.0511 0.3574
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0012 0.0039
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0095 0.0205
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.002 0.0142
Toxoplasma gondii protease inhibitor PI2 0.0086 0.0198 0.3493
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0035 0.0609
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0515 0.1729
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0021 0.0021
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0094 0.0319
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.0287 0.062
Echinococcus granulosus beta LACTamase domain containing family member 0.019 0.0511 0.1103
Loa Loa (eye worm) hypothetical protein 0.0126 0.0318 0.1078
Echinococcus multilocularis pol protein 0.1767 0.5246 0.5246
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0021 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0003 0.001
Echinococcus multilocularis Smad4 0.0035 0.0045 0.0045
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.0012 0.0203
Schistosoma mansoni organic anion transporter 0.0126 0.0318 0.0687
Echinococcus granulosus survival motor neuron protein 1 0.0267 0.0742 0.1602
Brugia malayi Doublecortin family protein 0.0045 0.0074 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0003 0.001
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0044 0.0071 0.0197
Loa Loa (eye worm) hypothetical protein 0.0067 0.014 0.0473
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0013 0.0028
Schistosoma mansoni microtubule-associated protein tau 0.1563 0.4632 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0156 0.0565
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0044 0.0071 0.0495
Schistosoma mansoni inositol monophosphatase 0.0042 0.0065 0.0141
Mycobacterium tuberculosis Probable conserved lipoprotein 0.019 0.0511 0.1424
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.0059 0.0246
Echinococcus multilocularis jumonji domain containing 1A 0.0036 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0319
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0073
Toxoplasma gondii LsmAD domain-containing protein 0.0109 0.0268 0.4729
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0044 0.0071 0.0495
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0319
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0095 0.0322
Mycobacterium ulcerans hypothetical protein 0.019 0.0511 0.3574
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0044 0.0071 0.0256
Leishmania major GMP synthase, putative,glutamine amidotransferase, putative 0.0037 0.0051 0.0186
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0094 0.0203
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0662 0.1927 0.6475
Mycobacterium ulcerans lipase LipD 0.019 0.0511 0.3574
Loa Loa (eye worm) hypothetical protein 0.019 0.0511 0.1731
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0047 0.0158
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0095 0.0095
Brugia malayi MH2 domain containing protein 0.0035 0.0045 0.0153
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.0816 0.2741
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0135 0.0457
Brugia malayi beta-NAC-like protein 0.0039 0.0059 0.0198
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0012 0.0039
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0209 0.0568 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0012 0.0039
Echinococcus multilocularis muscleblind protein 0.0338 0.0956 0.0956
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0047 0.0169
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0013 0.0043
Schistosoma mansoni rab6-interacting 0.0045 0.0074 0.0159
Mycobacterium ulcerans esterase/lipase LipP 0.019 0.0511 0.3574
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.0816 0.2741
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.1003 0.2952 1
Trichomonas vaginalis taga, putative 0.0024 0.0012 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0286 0.0962
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0149 0.0388 0.0388
Loa Loa (eye worm) runx1 0.0126 0.0318 0.1077
Toxoplasma gondii hypothetical protein 0.0152 0.0396 0.6976
Brugia malayi RNA, U transporter 1 0.009 0.0209 0.0708
Entamoeba histolytica hypothetical protein 0.0077 0.0172 0.0839
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0024 0.0012 0.0203
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0115 0.0286 0.1035
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0065 0.115
Schistosoma mansoni hypothetical protein 0.0044 0.0071 0.0153
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0086 0.0198 0.3493
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0056 0.0107 0.0231
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0059 0.0212
Schistosoma mansoni hypothetical protein 0.0045 0.0074 0.0159
Loa Loa (eye worm) agrin synaptic family protein 0.0086 0.0198 0.0672
Schistosoma mansoni multidrug resistance protein 0.0024 0.0012 0.0025
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0013 0.0004
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0135 0.0488
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0094 0.0203
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.002 0.0046
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0077 0.0172 0.0577
Mycobacterium leprae DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) 0.0464 0.1334 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.0039
Schistosoma mansoni lozenge 0.0126 0.0318 0.0686
Plasmodium falciparum ataxin-2 like protein, putative 0.0109 0.0268 0.2013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0094 0.0319
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0036
Schistosoma mansoni smad1 5 8 and 0.0035 0.0045 0.0097
Schistosoma mansoni GMP synthetase 0.0037 0.0051 0.0111
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0013 0.0043
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0132 0.0338 0.122
Trypanosoma brucei PAB1-binding protein , putative 0.0109 0.0268 0.097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0043
Brugia malayi AMP-binding enzyme family protein 0.0027 0.002 0.0069
Mycobacterium ulcerans NAD synthetase 0.0093 0.0219 0.1529
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0115 0.0286 0.097
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0126 0.0318 0.1078
Schistosoma mansoni agrin 0.0086 0.0198 0.0428
Loa Loa (eye worm) hypothetical protein 0.0126 0.0318 0.1078
Brugia malayi MH2 domain containing protein 0.0035 0.0045 0.0153
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0135 0.0645
Brugia malayi nuclear hormone receptor 0.0051 0.0094 0.0319
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0043
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0012 0.0025
Schistosoma mansoni inositol monophosphatase 0.0042 0.0065 0.0141
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0036 0.0047 0.0821
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0116 0.0287 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0156 0.0565
Leishmania major cytochrome p450-like protein 0.0071 0.0153 0.0555
Entamoeba histolytica hypothetical protein 0.0039 0.0059 0.0246
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0319
Schistosoma mansoni zinc finger protein 0.0028 0.0025 0.0054
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0024 0.0011 0.0023
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0045 0.0097
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0094 0.0203
Mycobacterium ulcerans hypothetical protein 0.0027 0.002 0.0142
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0033 0.004 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0109 0.0268 0.097
Leishmania major cathepsin L-like protease 0.0072 0.0156 0.0565
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0021 0.0073
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0044 0.0071 0.0495
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0044 0.0071 0.0256
Schistosoma mansoni hypothetical protein 0.0049 0.0087 0.0188
Mycobacterium tuberculosis DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) 0.0464 0.1334 0.3718
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0017 0.0056
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0515 0.1729
Loa Loa (eye worm) DR-78 0.0024 0.0013 0.0043
Echinococcus multilocularis RUN 0.0045 0.0074 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0044 0.0071 0.0197
Echinococcus multilocularis expressed protein 0.0086 0.0198 0.0198
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.019 0.0511 0.1731
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0095 0.0095
Onchocerca volvulus 0.0093 0.0219 0.0698
Plasmodium falciparum GMP synthase [glutamine-hydrolyzing] 0.0037 0.0051 0.0385
Mycobacterium tuberculosis Probable esterase LipL 0.019 0.0511 0.1424
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0039 0.0039
Brugia malayi hypothetical protein 0.0126 0.0318 0.1078
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0044 0.0071 0.0197
Loa Loa (eye worm) hypothetical protein 0.0037 0.0051 0.0174
Plasmodium falciparum glutamine-dependent NAD(+) synthetase, putative 0.0093 0.0219 0.1639
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0095 0.0282
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0013 0.0043
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.0424 0.1534
Mycobacterium tuberculosis Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing]) 0.0093 0.0219 0.0609
Trypanosoma cruzi MFS transporter, putative 0.0126 0.0318 0.115
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0012 0.0039
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0172 0.0372
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0033 0.004 0.004
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0044 0.0071 0.0197
Leishmania major hypothetical protein, conserved 0.019 0.0511 0.1846
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0116 0.0116
Brugia malayi sodium-independent organic anion transporter family protein 0.0126 0.0318 0.1078
Echinococcus granulosus mixed lineage leukemia protein mll 0.0028 0.0023 0.005
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0044 0.0071 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0094 0.0319
Schistosoma mansoni hypothetical protein 0.0906 0.2661 0.5743
Loa Loa (eye worm) hypothetical protein 0.0086 0.0198 0.0672
Schistosoma mansoni cpg binding protein 0.0093 0.0219 0.0472
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0035 0.0125
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0065 0.0219
Echinococcus granulosus transcription factor btf3 0.0039 0.0059 0.0126
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0319
Loa Loa (eye worm) hypothetical protein 0.0031 0.0035 0.0117
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0155 0.0525
Brugia malayi hypothetical protein 0.0027 0.0021 0.0073
Brugia malayi hypothetical protein 0.0045 0.0074 0.025
Brugia malayi PHD-finger family protein 0.0035 0.0044 0.0149
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0094 0.0203
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0132 0.0338 0.122
Schistosoma mansoni smdr2 0.0024 0.0012 0.0025
Brugia malayi Pre-SET motif family protein 0.0129 0.0328 0.1111
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0013 0.0044
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0155 0.0525
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0094 0.0319
Echinococcus granulosus lysine specific demethylase 5A 0.0141 0.0363 0.0783
Onchocerca volvulus 0.0051 0.0094 0.0279
Schistosoma mansoni nuclear receptor 0.0024 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.019 0.0511 0.1731
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0094 0.0094
Schistosoma mansoni nuclear receptor 0.0024 0.0013 0.0028
Onchocerca volvulus 0.0129 0.0328 0.1067
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0115 0.0286 0.1035
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0094 0.0203
Loa Loa (eye worm) inositol-1 0.0042 0.0065 0.0221
Schistosoma mansoni jumonji domain containing protein 0.0036 0.0047 0.0101
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0013 0.0013
Loa Loa (eye worm) histone methyltransferase 0.0033 0.004 0.0136
Schistosoma mansoni phosphatidylserine receptor 0.0036 0.0047 0.0101
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0012 0.0012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.0511 0.1103
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0032 0.0036 0.0036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0039 0.0083
Loa Loa (eye worm) multidrug resistance protein 3 0.0024 0.0012 0.0039
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0126 0.0318 0.0318
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0059 0.1032
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0023 0.005
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0077 0.0172 0.0371
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0382 0.1088 0.2349
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0071 0.0153 0.1073
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.019 0.0511 0.1424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0382 0.1088 0.2349
Brugia malayi hypothetical protein 0.0071 0.0152 0.0515
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0094 0.0094
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0052 0.0095 0.0322
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0013 0.0013
Toxoplasma gondii ABC1 family protein 0.019 0.0511 0.9
Echinococcus multilocularis Polycystic kidney disease protein 0.0045 0.0074 0.0074
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0446 0.1278 0.4618
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0036 0.0047 0.0821
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0044 0.0071 0.0197
Echinococcus multilocularis beta LACTamase domain containing family member 0.019 0.0511 0.0511
Trichomonas vaginalis abcb9, putative 0.0024 0.0012 0.0039
Leishmania major NAD synthase, putative 0.0093 0.0219 0.079
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0012 0.0039
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0172 0.0372
Echinococcus multilocularis GPCR, family 2 0.0033 0.0039 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0156 0.0565
Onchocerca volvulus 0.0047 0.008 0.023
Leishmania major cytochrome p450-like protein 0.0044 0.0071 0.0256
Trypanosoma brucei cytochrome P450, putative 0.0071 0.0153 0.0555
Trypanosoma brucei GMP synthase [glutamine-hydrolysing] 0.0037 0.0051 0.0186
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0132 0.0338 0.122
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.002 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0515 0.1729
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0003 0.001
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0012 0.0039
Brugia malayi nuclear receptor NHR-67 0.0024 0.0013 0.0043
Plasmodium falciparum multidrug resistance protein 1 0.0024 0.0012 0.0086
Plasmodium vivax multidrug resistance protein 1, putative 0.0024 0.0012 0.0203
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.002 0.0142
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0094 0.0203
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0033 0.0119
Mycobacterium tuberculosis Conserved hypothetical protein 0.0496 0.1429 0.3984
Trypanosoma cruzi NAD+ synthase, putative 0.0093 0.0219 0.079
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0003 0.001
Trichomonas vaginalis abcb9, putative 0.0024 0.0012 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0286 0.0962
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0044 0.0071 0.0256
Onchocerca volvulus 0.1011 0.2977 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0149 0.0388 0.0838
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0662 0.1927 1
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.0511 0.1716
Brugia malayi jmjC domain containing protein 0.0036 0.0047 0.0158
Onchocerca volvulus 0.019 0.0511 0.1684
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.0074 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0382 0.1088 0.2349
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0511 0.1846
Echinococcus granulosus caspase 8 0.002 0.000000018826 0.000000040639
Echinococcus granulosus dna polymerase eta 0.0044 0.0072 0.0156
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0319
Mycobacterium tuberculosis Probable lipase LipE 0.019 0.0511 0.1424
Plasmodium vivax hypothetical protein, conserved 0.019 0.0511 0.9
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0013 0.0013
Schistosoma mansoni phd/f-box containing protein 0.0036 0.0047 0.0101
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0053 0.0053
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.002 0.0142
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0094 0.0203
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0072 0.0261
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0047 0.0158
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0044 0.0071 0.0197
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0049 0.0087 0.0087
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0043 0.0069 0.015
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0043
Leishmania major DNA polymerase eta, putative 0.0031 0.0033 0.0119
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0047 0.008 0.027
Entamoeba histolytica hypothetical protein 0.0077 0.0172 0.0839
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0012 0.0039
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0094 0.0279
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0094 0.0203
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0546 0.1833
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0012 0.0039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0662 0.1927 0.6475
Loa Loa (eye worm) beta-lactamase 0.019 0.0511 0.1731
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0013 0.0028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0382 0.1088 0.1088
Schistosoma mansoni hypothetical protein 0.0054 0.0104 0.0224
Schistosoma mansoni bromodomain containing protein 0.008 0.018 0.0387
Plasmodium vivax multidomain scavenger receptor, putative 0.0045 0.0074 0.1299
Echinococcus granulosus Smad4 0.0035 0.0045 0.0097
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0044 0.0071 0.0495
Schistosoma mansoni protein phosphatase 2C 0.0036 0.0047 0.0101
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0045 0.0097
Brugia malayi nuclear receptor RXR 0.0024 0.0013 0.0043
Mycobacterium leprae Probable lipase LipE 0.019 0.0511 0.3735
Onchocerca volvulus 0.0024 0.0013 0.0004
Mycobacterium tuberculosis Probable lipase LipD 0.019 0.0511 0.1424
Brugia malayi nuclear receptor RXR 0.0027 0.0021 0.0073
Echinococcus multilocularis lysine specific demethylase 6a 0.0036 0.0047 0.0047
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0013 0.0043
Schistosoma mansoni transcription factor btf3 0.0039 0.0059 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0044 0.0071 0.0197
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0069
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0044 0.0071 0.0495
Schistosoma mansoni organic anion transporter 0.0126 0.0318 0.0687
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0135 0.0457
Echinococcus multilocularis mitogen activated protein kinase 0.0115 0.0286 0.0286
Mycobacterium ulcerans DNA-directed RNA polymerase subunit beta 0.0464 0.1334 0.9332
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.002 0.0074
Brugia malayi glutaminase DH11.1 0.0309 0.0867 0.2938
Echinococcus multilocularis muscleblind protein 1 0.0338 0.0956 0.0956
Loa Loa (eye worm) hypothetical protein 0.0086 0.0198 0.0672
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0129 0.0328 0.0708
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0073
Echinococcus granulosus tar DNA binding protein 0.0072 0.0155 0.0334
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0209 0.0568 0.1582
Loa Loa (eye worm) hypothetical protein 0.0045 0.0074 0.025
Schistosoma mansoni loxhd1 0.0045 0.0074 0.0159
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0292 0.0816 0.2764
Trichomonas vaginalis hypothetical protein 0.0209 0.0568 0.1907
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0003 0.001
Onchocerca volvulus 0.0126 0.0318 0.1034
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0323 0.0911 0.6373
Echinococcus multilocularis cpg binding protein 0.01 0.0241 0.0241
Brugia malayi steroid hormone receptor 0.0051 0.0094 0.0319
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0043 0.0069 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0382 0.1088 0.2349
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0003 0.001
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0155 0.0334
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0286 0.0618
Toxoplasma gondii glutamine-dependent NAD(+) synthetase protein, putative 0.0093 0.0219 0.385
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0012 0.0025
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0209 0.0568 0.3961
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0012 0.0039
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0044 0.0071 0.0495
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0024 0.0012 0.0039
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0044 0.0071 0.0197
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0155 0.0334
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0286 0.0962
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0094 0.0203
Schistosoma mansoni polycystin 1-related 0.0045 0.0074 0.0159
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0155 0.0155
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0662 0.1927 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.002 0.0142
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0135 0.0135
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0338 0.0956 0.3238
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0133 0.034 0.0734
Mycobacterium tuberculosis Conserved protein 0.019 0.0511 0.1424
Echinococcus granulosus zinc finger protein 0.0028 0.0025 0.0054
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0196 0.0527 0.1138
Schistosoma mansoni hypothetical protein 0.0906 0.2661 0.5743
Brugia malayi hypothetical protein 0.1003 0.2952 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0083 0.019 0.019
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.0012 0.0025
Echinococcus granulosus JmjC domain containing protein 4 0.0036 0.0047 0.0101
Brugia malayi hypothetical protein 0.0126 0.0318 0.1078
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0209 0.0568 0.4256
Echinococcus multilocularis dnaJ subfamily B 0.0926 0.2721 0.2721
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0065 0.0236
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0319
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0086 0.0198 0.0672
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.0059 0.0439
Onchocerca volvulus 0.0126 0.0318 0.1034
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0515 0.1729
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0059 0.0212
Plasmodium falciparum DNA-directed RNA polymerase subunit beta, putative 0.0464 0.1334 1
Schistosoma mansoni DNA polymerase eta 0.0044 0.0072 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0094 0.0319
Onchocerca volvulus Glucosylceramidase homolog 0.0191 0.0515 0.1697
Loa Loa (eye worm) RNA binding protein 0.0072 0.0155 0.0525
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.0511 0.1716
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0286 0.0962
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0155 0.0334
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0116 0.0251
Echinococcus granulosus follistatin 0.0086 0.0198 0.0428
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0065 0.0141
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0515 0.1729
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0043
Brugia malayi hypothetical protein 0.0109 0.0268 0.0909
Echinococcus granulosus mitogen activated protein kinase 0.0115 0.0286 0.0618
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.0816 0.2741
Brugia malayi nuclear hormone receptor 0.0024 0.0013 0.0043
Leishmania major cathepsin L-like protease 0.0072 0.0156 0.0565
Brugia malayi sodium-independent organic anion transporter family protein 0.0126 0.0318 0.1078
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0035 0.0035
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0138 0.0497
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0889 0.2609 0.8838
Echinococcus multilocularis phd:f box containing protein 0.0036 0.0047 0.0047
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0292 0.0816 0.2764
Mycobacterium leprae putative cytochrome p450 0.0044 0.0071 0.0384
Mycobacterium ulcerans GMP synthase 0.0037 0.0051 0.0359
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0149 0.0388 0.0838
Brugia malayi MAP kinase sur-1 0.0115 0.0286 0.097
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0073
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0003 0.001
Brugia malayi jmjC domain containing protein 0.0036 0.0047 0.0158
Echinococcus multilocularis snurportin 1 0.0336 0.0949 0.0949
Onchocerca volvulus 0.0126 0.0318 0.1034
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.002 0.000000018826 0.000000040639
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0013 0.0028
Onchocerca volvulus Putative organic anion transporter 0.0126 0.0318 0.1034
Schistosoma mansoni hypothetical protein 0.0071 0.0153 0.033
Loa Loa (eye worm) hypothetical protein 0.0048 0.0084 0.0284
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0086 0.0198 0.3493
Brugia malayi Cell death protein 3 precursor 0.0067 0.014 0.0473
Echinococcus multilocularis 0.0044 0.0071 0.0071
Schistosoma mansoni multidrug resistance protein 0.0024 0.0012 0.0025
Plasmodium falciparum JmjC domain-containing protein, putative 0.0036 0.0047 0.035
Loa Loa (eye worm) hypothetical protein 0.0126 0.0318 0.1078
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0013 0.0028
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0135 0.0488
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0043
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0 0.0001
Plasmodium vivax ataxin-2 like protein, putative 0.0109 0.0268 0.4729
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0094 0.0094
Schistosoma mansoni smad 0.0035 0.0045 0.0097
Echinococcus multilocularis lipoxygenase domain containing protein 0.0045 0.0074 0.0074
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0035 0.0125
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.0816 0.2741
Loa Loa (eye worm) hypothetical protein 0.0109 0.0268 0.0909
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0003 0.001
Brugia malayi mbt repeat family protein 0.0052 0.0095 0.0322
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0172 0.0172
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0021 0.0046
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0323 0.0911 0.2539
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0094 0.0319
Schistosoma mansoni multidrug resistance protein 0.0024 0.0012 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0156 0.0565
Loa Loa (eye worm) hypothetical protein 0.019 0.0511 0.1731
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0013 0.0028
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0126 0.0318 0.0318
Brugia malayi jmjC domain containing protein 0.0036 0.0047 0.0158
Brugia malayi jmjC domain containing protein 0.0141 0.0363 0.1228
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0123 0.0308 0.0665
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0072 0.0261
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0095 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.0816 0.2741
Schistosoma mansoni glutamine-dependent NAD(+) synthetase 0.0093 0.0219 0.0472
Brugia malayi secreted modular calcium-binding protein 1 0.0086 0.0198 0.0672
Schistosoma mansoni lipoxygenase 0.0196 0.0527 0.1138
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0382 0.1088 0.3686
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0059 0.0198
Brugia malayi conserved hypotetical protein 0.0024 0.0013 0.0043
Echinococcus multilocularis GMP synthase (glutamine hydrolyzing) 0.0037 0.0051 0.0051
Plasmodium vivax glutamine-dependent NAD(+) synthetase, putative 0.0093 0.0219 0.385
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0012 0.0039
Echinococcus multilocularis mitogen activated protein kinase 3 0.0115 0.0286 0.0286
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0024 0.0012 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0094 0.0319
Echinococcus multilocularis caspase 2 0.0067 0.014 0.014
Echinococcus granulosus snurportin 1 0.0336 0.0949 0.205
Brugia malayi TAR-binding protein 0.0072 0.0155 0.0525
Loa Loa (eye worm) hypothetical protein 0.0086 0.0198 0.0672
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0094 0.0203
Trypanosoma cruzi cytochrome P450, putative 0.0071 0.0153 0.0555
Leishmania major mitochondrial DNA polymerase beta 0.0942 0.2767 1
Schistosoma mansoni importin beta-1 0.0031 0.0035 0.0075
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0059 0.0116 0.0395
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0044 0.0071 0.0256
Brugia malayi jmjC domain containing protein 0.0133 0.034 0.1152
Loa Loa (eye worm) hypothetical protein 0.0036 0.0047 0.0158
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0115 0.0286 0.5047
Echinococcus multilocularis geminin 0.0906 0.2661 0.2661
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0086 0.0198 0.0672
Trypanosoma brucei RNA helicase, putative 0.0109 0.0269 0.0971
Entamoeba histolytica NAD synthetase, putative 0.0093 0.0219 0.1081
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0382 0.1088 0.3686
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0086 0.0198 0.3493
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0039 0.0131
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0069
Brugia malayi hypothetical protein 0.0267 0.0742 0.2514
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0094 0.0094
Brugia malayi Bromodomain containing protein 0.0094 0.0221 0.0748
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0942 0.2767 1
Chlamydia trachomatis DNA-directed RNA polymerase subunit beta 0.0464 0.1334 1
Brugia malayi prostaglandin transporter 0.0126 0.0318 0.1078
Brugia malayi Melibiase family protein 0.0077 0.0172 0.0582
Echinococcus multilocularis JmjC domain containing protein 4 0.0036 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0024 0.0013 0.0028
Brugia malayi beta-lactamase family protein 0.019 0.0511 0.1731
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0446 0.1278 0.4618
Plasmodium falciparum enoyl-acyl carrier reductase 0.0209 0.0568 0.4256
Trichomonas vaginalis abcb9, putative 0.0024 0.0012 0.0039
Brugia malayi Pre-SET motif family protein 0.0889 0.2609 0.8838
Loa Loa (eye worm) glutaminase 0.0309 0.0867 0.2938
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0000069827 0.0001
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0115 0.0286 0.1035
Trypanosoma brucei NAD+ synthase, putative 0.0093 0.0219 0.079
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0021 0.0073
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0086 0.0198 0.0672
Plasmodium vivax SET domain protein, putative 0.0129 0.0328 0.5779
Schistosoma mansoni hypothetical protein 0.0077 0.0172 0.0372
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0511 0.1846
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0328 0.0708
Echinococcus granulosus cytochrome P450 2K1 0.0044 0.0071 0.0153
Onchocerca volvulus 0.0045 0.0074 0.021
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0047 0.0158
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.0287 0.062
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0052 0.0145
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0044 0.0071 0.0197
Onchocerca volvulus 0.0086 0.0198 0.063
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0446 0.1278 0.4618
Schistosoma mansoni lipoxygenase 0.0115 0.0287 0.0618
Loa Loa (eye worm) hypothetical protein 0.019 0.0511 0.1731
Brugia malayi hypothetical protein 0.0045 0.0074 0.025
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0129 0.0328 0.0328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0094 0.0319
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.0039
Leishmania major DNA polymerase eta, putative 0.0044 0.0072 0.0261
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0095 0.0205
Onchocerca volvulus Putative organic anion transporter 0.0126 0.0318 0.1034
Echinococcus multilocularis Protein lozenge 0.0126 0.0318 0.0318
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0036 0.0047 0.0169
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0094 0.0203
Brugia malayi beta-lactamase family protein 0.019 0.0511 0.1731
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0094 0.0319
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0662 0.1927 0.6475
Brugia malayi nuclear receptor NHR-88 0.0024 0.0013 0.0043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0662 0.1927 0.6475
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0012 0.0039
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0094 0.0319
Echinococcus multilocularis smad 0.0035 0.0045 0.0045
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0024 0.0012 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0094 0.0319
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0024 0.0012 0.0032
Schistosoma mansoni cpg binding protein 0.01 0.0241 0.0521
Echinococcus granulosus apoptotic protease activating factor 1 0.0047 0.008 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0156 0.0565
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.019 0.0511 0.1424
Plasmodium vivax GMP synthetase, putative 0.0037 0.0051 0.0905
Brugia malayi sodium-independent organic anion transporter family protein 0.0126 0.0318 0.1078
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0012 0.0039
Loa Loa (eye worm) cytochrome P450 0.0044 0.0071 0.024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0382 0.1088 0.1088
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.002 0.0074
Onchocerca volvulus 0.0045 0.0074 0.021
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0044 0.0071 0.0495
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0003 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0094 0.0319
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0077 0.0172 0.0371
Leishmania major cathepsin L-like protease 0.0072 0.0156 0.0565
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0116 0.0251
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0065 0.0236
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0012 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0003 0.001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0129 0.0328 0.5779
Schistosoma mansoni survival motor neuron protein 0.0054 0.0104 0.0224
Onchocerca volvulus 0.019 0.0511 0.1684
Schistosoma mansoni hypothetical protein 0.0033 0.0039 0.0083
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0942 0.2767 1
Schistosoma mansoni retinoic acid receptor RXR 0.0163 0.0429 0.0925
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0094 0.0203
Loa Loa (eye worm) hypothetical protein 0.0033 0.0039 0.0131
Echinococcus granulosus dnaJ subfamily B 0.0926 0.2721 0.5874
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0094 0.0203
Brugia malayi ABC transporter family protein 0.0024 0.0012 0.0039
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.002 0.0142
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0065 0.0456
Echinococcus multilocularis pol protein 0.1767 0.5246 0.5246
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0043
Toxoplasma gondii cytochrome p450 superfamily protein 0.0044 0.0071 0.1248
Brugia malayi Inositol-1 0.0042 0.0065 0.0221
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0252 0.0852
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0067 0.0145
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0013 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0662 0.1927 0.6475
Onchocerca volvulus 0.0126 0.0318 0.1034
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0094 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0094 0.0319
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0155 0.0334
Loa Loa (eye worm) hypothetical protein 0.0126 0.0318 0.1078
Echinococcus granulosus Solute carrier organic anion transporter family 0.0126 0.0318 0.0687
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0012 0.0025
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0336 0.0949 0.3216
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0323 0.0911 0.678
Leishmania major hypothetical protein, conserved 0.0036 0.0047 0.0169
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0515 0.1729
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0094 0.0319
Loa Loa (eye worm) hypothetical protein 0.0044 0.0072 0.0245
Echinococcus granulosus GPCR family 2 0.0033 0.0039 0.0083
Onchocerca volvulus Cell death protein 3 homolog 0.0067 0.014 0.0432
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.0511 0.1716
Echinococcus granulosus histone lysine methyltransferase setb 0.0149 0.0388 0.0838
Giardia lamblia Fructose-bisphosphate aldolase 0.0662 0.1927 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0013 0.0004
Schistosoma mansoni hypothetical protein 0.0033 0.0039 0.0083
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0044 0.0071 0.0197
Loa Loa (eye worm) MBCTL1 0.0059 0.0116 0.0395
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0115 0.0286 0.1035
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0003 0.001
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0013 0.0028
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0072 0.0245
Loa Loa (eye worm) hypothetical protein 0.0086 0.0198 0.0672
Brugia malayi Muscleblind-like protein 0.0338 0.0956 0.3238
Toxoplasma gondii bifunctional GMP synthase/glutamine amidotransferase protein 0.0037 0.0051 0.0905
Loa Loa (eye worm) hypothetical protein 0.0126 0.0318 0.1078
Onchocerca volvulus 0.0024 0.0013 0.0004
Mycobacterium ulcerans glutaminase 0.0309 0.0867 0.6068
Brugia malayi Cytochrome P450 family protein 0.0071 0.0153 0.052
Loa Loa (eye worm) cytochrome P450 family protein 0.0071 0.0153 0.052
Loa Loa (eye worm) hypothetical protein 0.0071 0.0153 0.0518
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0012 0.0039
Treponema pallidum DNA-directed RNA polymerase subunit beta 0.0464 0.1334 0.6525
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0044 0.0071 0.0197
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0036 0.0047 0.0101
Brugia malayi Importin beta-1 subunit 0.0031 0.0035 0.0117
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0515 0.1729
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0104 0.0351
Schistosoma mansoni rab6-interacting 0.0045 0.0074 0.0159
Echinococcus granulosus jumonji domain containing 1A 0.0036 0.0047 0.0101
Brugia malayi hypothetical protein 0.0027 0.0021 0.0073
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0319
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0065 0.0281
Echinococcus granulosus RUN 0.0045 0.0074 0.0159
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0094 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0003 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0156 0.0565
Schistosoma mansoni caspase-7 (C14 family) 0.0067 0.014 0.0302
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0044 0.0071 0.0495
Echinococcus granulosus smad 0.0035 0.0045 0.0097
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0065 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0059 0.0197
Entamoeba histolytica hypothetical protein 0.0077 0.0172 0.0839
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0047 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0094 0.0319
Schistosoma mansoni smad1 5 8 and 0.0035 0.0045 0.0097
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0044 0.0071 0.0197
Brugia malayi AMP-binding enzyme family protein 0.0027 0.002 0.0069
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0043
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0032 0.0036 0.0077
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0126 0.0318 0.0687
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0043
Loa Loa (eye worm) hypothetical protein 0.0051 0.0094 0.0319
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0052 0.0242
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0077
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0044 0.0071 0.0495
Schistosoma mansoni hypothetical protein 0.0033 0.0039 0.0083
Brugia malayi AMP-binding enzyme family protein 0.0027 0.002 0.0069
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0115 0.0286 0.1035
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0012 0.0025
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0094 0.0203
Brugia malayi Cytochrome P450 family protein 0.0044 0.0071 0.024
Toxoplasma gondii melibiase subfamily protein 0.0116 0.0287 0.5063
Plasmodium vivax importin-beta 2, putative 0.0031 0.0035 0.0609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0662 0.1927 0.6475
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0044 0.0071 0.0197
Mycobacterium leprae PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING]) 0.0093 0.0219 0.1509
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0094 0.0203
Brugia malayi mbt repeat family protein 0.0052 0.0095 0.0322
Brugia malayi Smad1 0.0035 0.0045 0.0153
Loa Loa (eye worm) hypothetical protein 0.0045 0.0076 0.0256
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0252 0.0852
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0094 0.0319
Trypanosoma cruzi PAB1-binding protein , putative 0.0109 0.0268 0.097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0156 0.0565
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0013 0.0043
Loa Loa (eye worm) cytochrome P450 family protein 0.0142 0.0366 0.124
Brugia malayi nuclear receptor NHR-88 0.0051 0.0094 0.0319
Brugia malayi multidrug resistance protein 3 0.0024 0.0012 0.0039
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0013 0.0013
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0094 0.0319
Mycobacterium tuberculosis Probable hydrolase 0.019 0.0511 0.1424
Onchocerca volvulus 0.019 0.0511 0.1684
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0132 0.0338 0.122
Mycobacterium leprae conserved hypothetical protein 0.019 0.0511 0.3735
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0094 0.0319
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0044 0.0071 0.0495
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0013 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0382 0.1088 0.2349
Echinococcus multilocularis lysine specific demethylase 5A 0.0133 0.034 0.034
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0094 0.0279
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0155 0.0334
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0044 0.0071 0.0495
Loa Loa (eye worm) hypothetical protein 0.019 0.0511 0.1731
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1215 0.3587 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0045 0.0045
Echinococcus granulosus caspase 2 0.0067 0.014 0.0302
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0135 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0094 0.0319
Brugia malayi MH2 domain containing protein 0.0514 0.1483 0.5022
Echinococcus multilocularis caspase 8 0.002 0.000000018826 0.000000018826
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0942 0.2767 1
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0546 0.1833
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.002 0.0074
Loa Loa (eye worm) hypothetical protein 0.0055 0.0107 0.0361
Loa Loa (eye worm) jmjC domain-containing protein 0.0141 0.0363 0.1228
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0094 0.0279
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0012 0.0012
Mycobacterium ulcerans beta-lactamase 0.019 0.0511 0.3574
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0045 0.0097
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0094 0.0094
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0116 0.0251
Schistosoma mansoni hypothetical protein 0.0109 0.0269 0.058
Plasmodium falciparum ataxin-2 like protein, putative 0.0109 0.0268 0.2013
Echinococcus multilocularis pol protein 0.1767 0.5246 0.5246
Echinococcus granulosus cpg binding protein 0.01 0.0241 0.0521
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0073
Brugia malayi hypothetical protein 0.0024 0.0013 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0156 0.0565
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0094 0.0319
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0003 0.001
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0045 0.0045
Mycobacterium tuberculosis Conserved protein 0.019 0.0511 0.1424
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0012 0.0039
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.0074 0.0159
Onchocerca volvulus 0.0126 0.0318 0.1034
Onchocerca volvulus 0.0027 0.002 0.003
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0033 0.058
Echinococcus granulosus lipoxygenase domain containing protein 0.0045 0.0074 0.0159
Trichomonas vaginalis nh(3)-dependent NAD(+) synthetase, putative 0.0093 0.0219 0.0734
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0153 0.0518
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0116 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0149 0.0388 0.1315
Loa Loa (eye worm) MH2 domain-containing protein 0.0514 0.1483 0.5022
Toxoplasma gondii transporter, major facilitator family protein 0.0126 0.0318 0.5607
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0044 0.0071 0.0495
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0013 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0003 0.001
Onchocerca volvulus 0.0052 0.0095 0.0282
Echinococcus granulosus fetal alzheimer antigen falz 0.0032 0.0036 0.0077
Loa Loa (eye worm) hypothetical protein 0.1003 0.2952 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0116 0.0287 0.062
Loa Loa (eye worm) hypothetical protein 0.0104 0.0252 0.0852
Entamoeba histolytica hypothetical protein 0.0026 0.0017 0.0027
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0135 0.0291
Wolbachia endosymbiont of Brugia malayi DNA-directed RNA polymerase subunit beta/beta' 0.0464 0.1334 1
Loa Loa (eye worm) hypothetical protein 0.0126 0.0318 0.1078
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0044 0.0071 0.0197
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0039 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0059 0.0197
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0002 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.002 0.0142
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0000069827 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0003 0.001
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0116 0.0395
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0023 0.005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0252 0.0852
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0094 0.0319
Schistosoma mansoni Smad4 0.0035 0.0045 0.0097
Schistosoma mansoni jumonji/arid domain-containing protein 0.0141 0.0363 0.0783
Echinococcus multilocularis apoptotic protease activating factor 1 0.0047 0.008 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0003 0.001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0094 0.0203
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0036 0.0047 0.0169
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0013 0.0043
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0039 0.0039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.019 0.0511 0.1731
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0044 0.0071 0.0495
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.0012 0.0012
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0136 0.0347 0.0347
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0094 0.0094
Onchocerca volvulus Putative organic anion transporter 0.0126 0.0318 0.1034
Leishmania major importin beta-1 subunit, putative 0.0026 0.0017 0.006
Echinococcus granulosus GMP synthase glutamine hydrolyzing 0.0037 0.0051 0.0111
Brugia malayi tailless protein 0.0024 0.0013 0.0043
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.0511 0.1103
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0059 0.0212
Leishmania major basic transcription factor 3a, putative 0.0039 0.0059 0.0212
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0095 0.0205
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0013 0.0028
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0095 0.0205
Echinococcus granulosus mitogen activated protein kinase 3 0.0115 0.0286 0.0618
Echinococcus multilocularis zinc finger protein 0.0028 0.0025 0.0025
Loa Loa (eye worm) transcription factor SMAD2 0.0514 0.1483 0.5022
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0044 0.0071 0.0495
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0201 0.0545 0.1176
Echinococcus multilocularis pol protein 0.1767 0.5246 0.5246
Loa Loa (eye worm) Smad1 0.0035 0.0045 0.0153
Onchocerca volvulus 0.0054 0.0104 0.031
Leishmania major hypothetical protein, conserved 0.0109 0.0268 0.097
Loa Loa (eye worm) hypothetical protein 0.0036 0.0047 0.0158
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0065 0.0065
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0086 0.0198 0.0672
Brugia malayi MH1 domain containing protein 0.0035 0.0045 0.0153
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0209 0.0568 0.3972
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.002 0.0046
Echinococcus granulosus microtubule associated protein 2 0.1563 0.4632 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0012 0.0039
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0065 0.0219
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.0012 0.0039
Echinococcus multilocularis survival motor neuron protein 1 0.0267 0.0742 0.0742
Brugia malayi ecdysone receptor 0.0024 0.0013 0.0043
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0044 0.0071 0.0197
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0115 0.0286 0.1035
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0094 0.0094
Brugia malayi beta-lactamase 0.019 0.0511 0.1731
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0094 0.0319
Leishmania major p-glycoprotein 0.0024 0.0012 0.0042
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0044 0.0071 0.0495
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0156 0.0565
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0012 0.0039
Echinococcus granulosus nuclear factor of activated T cells 5 0.0083 0.019 0.041
Mycobacterium tuberculosis Conserved protein 0.019 0.0511 0.1424
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0013 0.0028
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0094 0.0094
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.002 0.0046
Onchocerca volvulus 0.1003 0.2952 0.9914
Loa Loa (eye worm) CYP4Cod1 0.0071 0.0153 0.052
Echinococcus multilocularis ATP binding cassette sub family B 0.0024 0.0011 0.0011
Echinococcus multilocularis transcription factor btf3 0.0039 0.0059 0.0059
Schistosoma mansoni cytochrome P450 0.0044 0.0071 0.0153
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.019 0.0511 0.1731
Brugia malayi cytochrome P450 0.0044 0.0071 0.024
Echinococcus granulosus geminin 0.0906 0.2661 0.5743
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0059 0.0197
Schistosoma mansoni zinc finger protein 0.0024 0.0013 0.0028
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0021 0.0046
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0059 0.1032
Loa Loa (eye worm) doublecortin family protein 0.0045 0.0074 0.025
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0046 0.0155
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.0012 0.0039
Plasmodium vivax JmjC domain containing protein 0.0036 0.0047 0.0821
Brugia malayi hypothetical protein 0.0077 0.0172 0.0584
Trichomonas vaginalis helicase, putative 0.0021 0.0003 0.001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0094 0.0203
Schistosoma mansoni hypothetical protein 0.0314 0.0882 0.1905
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0012 0.0039
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0156 0.0565
Schistosoma mansoni hypothetical protein 0.0047 0.008 0.0172
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0012 0.0039
Brugia malayi MH1 domain containing protein 0.0035 0.0045 0.0153
Brugia malayi ecdysteroid receptor 0.0051 0.0094 0.0319
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0053 0.0114
Echinococcus multilocularis dna polymerase eta 0.0044 0.0072 0.0072
Trichomonas vaginalis ABC transporter, putative 0.0024 0.0012 0.0039
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0167 0.0167
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0135 0.0488
Echinococcus granulosus importin subunit beta 1 0.0031 0.0035 0.0075
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0017 0.006
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0044 0.0071 0.0495
Echinococcus granulosus agrin 0.0086 0.0198 0.0428
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0156 0.0565
Loa Loa (eye worm) hypothetical protein 0.0077 0.0172 0.0582
Treponema pallidum fructose-bisphosphate aldolase 0.0662 0.1927 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0044 0.0071 0.0495
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0044 0.0071 0.0197
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0049 0.0087 0.0188
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.002 0.0142
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0662 0.1927 0.6475
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0135 0.0488
Mycobacterium leprae Conserved hypothetical protein 0.0044 0.0071 0.0384
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0039 0.0083
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.0012 0.0039
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.0816 0.2741
Trichomonas vaginalis glutaminase, putative 0.0309 0.0867 0.2913
Brugia malayi Cytochrome P450 family protein 0.0142 0.0366 0.124
Trypanosoma cruzi NAD+ synthase, putative 0.0093 0.0219 0.079
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0044 0.0071 0.0256
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0044 0.0071 0.0197
Schistosoma mansoni smad1 5 8 and 0.0035 0.0045 0.0097
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0155 0.0525
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0115 0.0286 0.1035
Loa Loa (eye worm) hypothetical protein 0.0024 0.0013 0.0043
Echinococcus multilocularis follistatin 0.0086 0.0198 0.0198
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.0511 0.1716

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.1413 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 0.7375 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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