Detailed view for ML1259

Basic information

TDR Targets ID: 979708
Mycobacterium leprae, Probable imidazole glycerol-phosphate dehydratase HisB
Source Database / ID:  Leproma 

pI: 6.6883 | Length (AA): 210 | MW (Da): 22893 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Histidine metabolism (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 200 5xds (A) 10 200 87.00 0 1 2.04252 -1.7

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129258)

Species Accession Gene Product
Arabidopsis thaliana AT4G14910   Imidazoleglycerol-phosphate dehydratase 2
Arabidopsis thaliana AT3G22425   Imidazoleglycerol-phosphate dehydratase 1
Candida albicans CaO19.183   Imidazole glycerol phosphate dehydratase
Candida albicans CaO19.7813   Imidazole glycerol phosphate dehydratase
Escherichia coli b2022   fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase
Mycobacterium leprae ML1259   Probable imidazole glycerol-phosphate dehydratase HisB
Mycobacterium tuberculosis Rv1601   Probable imidazole glycerol-phosphate dehydratase HisB
Mycobacterium ulcerans MUL_1574   imidazoleglycerol-phosphate dehydratase
Oryza sativa 4337007   Os04g0617800
Saccharomyces cerevisiae YOR202W   imidazoleglycerol-phosphate dehydratase HIS3

Essentiality

ML1259 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu1629 Mycobacterium tuberculosis essential nmpdr
b2022 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Cryptococcus neoformans var. neoformans B-3501A Imidazoleglycerol-phosphate dehydratase Compounds References
Escherichia coli fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0337 0.4388 0.5
0.0595 0.4196 0.5
0.174 0.421 1
0.107 0.261 1
0.089 0.4896 1
0.0595 0.4196 0.5
0.0734 0.4896 1
0.2984 0.49 0.5
0.2984 0.49 0.5
0.0337 0.3791 1
0.1981 0.4494 0.5
0.0863 0.4831 0.5
0.2336 0.4922 1
0.0602 0.4712 0.5
0.0704614 0.486488 0.5
0.056 0.411 0.5
0.2984 0.49 0.5
0.0704614 0.486488 0.5
0.0156052 0.45581 0.5
0.3003 0.4923 1
0.3193 0.4919 1
0.0337 0.413 1
0.174 0.421 1
0.2984 0.49 0.5
0.591 0.4926 1
0.0455288 0.461495 0.5
0.0337 0.27 0.2071
0.0863 0.4831 0.5
0.2984 0.49 0.5
0.3003 0.4923 1
0.088 0.4913 1
0.0337 0.3797 0.5
0.6779 0.4924 1
0.0337 0.4589 1
0.0337 0.37 1
0.0904 0.3681 0.5
0.107 0.261 1
0.0337 0.4671 1
0.0337 0.3769 1
0.12 0.4904 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier ML1259 (Mycobacterium leprae), Probable imidazole glycerol-phosphate dehydratase HisB
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