Detailed information for compound 1177583

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 638.789 | Formula: C40H46O7
  • H donors: 0 H acceptors: 0 LogP: 8.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=C(c1ccc(cc1)Oc1ccc(cc1)C(=C)C1COC2(OO1)C1CC3CC2CC(C1)C3)C1COC2(OO1)C1CC3CC2CC(C1)C3
  • InChi: 1S/C40H46O7/c1-23(37-21-41-39(46-44-37)31-13-25-11-26(15-31)16-32(39)14-25)29-3-7-35(8-4-29)43-36-9-5-30(6-10-36)24(2)38-22-42-40(47-45-38)33-17-27-12-28(19-33)20-34(40)18-27/h3-10,25-28,31-34,37-38H,1-2,11-22H2
  • InChiKey: RZLJLJBEMWGLJD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0067
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0109 0.1793
Brugia malayi hypothetical protein 0.0027 0.0029 0.0104
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0053 0.0095 0.5092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0095 0.1501
Mycobacterium ulcerans aldehyde dehydrogenase 0.0257 0.0598 0.1117
Onchocerca volvulus 0.0033 0.0045 0.0296
Trypanosoma cruzi ISWI complex protein 0.0047 0.0078 0.417
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0018 0.0008 0.001
Brugia malayi CXXC zinc finger family protein 0.0033 0.0045 0.0163
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0008 0.001
Loa Loa (eye worm) hypothetical protein 0.018 0.0407 0.1471
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.0532 0.2129
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0184 0.0418 0.0415
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0008 0.0094
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0241 0.0558 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.007 0.0136 0.2174
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0061 0.0949
Schistosoma mansoni tar DNA-binding protein 0.0275 0.0644 0.2579
Echinococcus granulosus dnaJ subfamily B 0.0474 0.1135 0.2645
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0087 0.0308
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0087 0.0341
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0029 0.0104
Trypanosoma brucei importin beta-1 subunit, putative 0.0086 0.0176 0.9611
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0087 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0095 0.1501
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0235
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0049 0.0109
Loa Loa (eye worm) hypothetical protein 0.0056 0.0102 0.0362
Loa Loa (eye worm) hypothetical protein 0.0054 0.0097 0.0342
Schistosoma mansoni hypothetical protein 0.0023 0.002 0.0069
Trichomonas vaginalis esterase, putative 0.0077 0.0153 0.2454
Loa Loa (eye worm) Smad1 0.0077 0.0152 0.0544
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0066 0.0126 0.2014
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0011 0.0016
Schistosoma mansoni ran 0.0064 0.012 0.0472
Brugia malayi tailless protein 0.0024 0.0021 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0068 0.106
Schistosoma mansoni cpg binding protein 0.0041 0.0064 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0076 0.1191
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0021 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0061 0.0949
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0014 0.019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0014 0.019
Trypanosoma brucei trypanothione reductase 0.0047 0.0078 0.4178
Treponema pallidum hypothetical protein 0.0018 0.0008 0.0099
Schistosoma mansoni ferritin 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0077 0.0153 0.0547
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0083 0.0168 0.063
Toxoplasma gondii thioredoxin reductase 0.0047 0.0078 0.1269
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0076 0.1191
Giardia lamblia Hypothetical protein 0.0089 0.0183 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0047 0.0162
Echinococcus granulosus importin 5 0.0016 0.0003 0.0001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0006 0.0049
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0462 0.1671
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0061 0.0949
Loa Loa (eye worm) hypothetical protein 0.0182 0.0413 0.1494
Schistosoma mansoni hypothetical protein 0.0063 0.0118 0.0465
Schistosoma mansoni farnesylated-protein converting enzyme 1 (M48 family) 0.0066 0.0126 0.0497
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0021 0.0015 0.0028
Echinococcus granulosus fetal alzheimer antigen falz 0.0071 0.0137 0.0315
Loa Loa (eye worm) hypothetical protein 0.0077 0.0153 0.0547
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0036 0.0133
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0087 0.0645
Mycobacterium ulcerans lipase LipD 0.0077 0.0153 0.0282
Echinococcus granulosus neuropeptide receptor 0.0188 0.0428 0.0994
Loa Loa (eye worm) hypothetical protein 0.0567 0.1366 0.4966
Toxoplasma gondii hypothetical protein 0.0018 0.0008 0.0093
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0153 0.0282
Schistosoma mansoni tar DNA-binding protein 0.0275 0.0644 0.2579
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0228
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0923 0.2245 0.8167
Plasmodium falciparum thioredoxin reductase 0.0047 0.0078 0.136
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0087 0.0308
Giardia lamblia DINP protein human, muc B family 0.002 0.0011 0.0462
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0021 0.0104
Brugia malayi nuclear receptor NHR-67 0.0024 0.0021 0.0078
Brugia malayi steroid hormone receptor 0.005 0.0087 0.0318
Echinococcus multilocularis dna polymerase eta 0.002 0.0011 0.0008
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0008 0.0288
Echinococcus granulosus snurportin 1 0.0923 0.2245 0.5235
Echinococcus granulosus histone lysine methyltransferase setb 0.0082 0.0164 0.0378
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0064 0.012 0.6489
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0168 0.2973
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0226 0.0854
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0153 0.0282
Plasmodium vivax glutathione reductase, putative 0.0047 0.0078 0.136
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0067
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0086 0.2014
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0153 0.2454
Leishmania major hypothetical protein, conserved 0.0077 0.0153 0.253
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB 0.217 0.533 1
Echinococcus multilocularis zinc finger protein 0.0062 0.0115 0.0112
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0067
Mycobacterium ulcerans glutaminase 0.0264 0.0616 0.1151
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0087 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0087 0.0318
Brugia malayi RNA, U transporter 1 0.0246 0.057 0.2076
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0031 0.0067
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0021 0.0078
Loa Loa (eye worm) hypothetical protein 0.0037 0.0055 0.019
Brugia malayi N-terminal motif family protein 0.0182 0.0413 0.1504
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0205 0.0746
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0087 0.0341
Brugia malayi beta-lactamase 0.0077 0.0153 0.0557
Chlamydia trachomatis hypothetical protein 0.0018 0.0008 0.0099
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0164 0.2637
Brugia malayi RNA binding protein 0.0275 0.0644 0.2342
Plasmodium vivax importin-beta 2, putative 0.0086 0.0176 0.3128
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0153 0.2454
Brugia malayi Latrophilin receptor protein 2 0.018 0.0407 0.148
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0099 0.0351
Schistosoma mansoni neuropeptide receptor 0.0188 0.0428 0.1714
Echinococcus granulosus tar DNA binding protein 0.0275 0.0644 0.1497
Trypanosoma brucei metallo- peptidase, Clan M- Family M48 0.0066 0.0126 0.6832
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0087 0.0318
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.1021 0.2488 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0567 0.1366 0.4971
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0241 0.0558 0.9337
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0021 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.023 0.0532 0.1236
Trichomonas vaginalis hypothetical protein 0.0016 0.0003 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.005 0.0089
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0241 0.0558 0.1043
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0117 0.0252 0.0907
Loa Loa (eye worm) RNA binding protein 0.0275 0.0644 0.2334
Loa Loa (eye worm) hypothetical protein 0.0256 0.0595 0.2158
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0007 0.0017
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0153 0.0282
Brugia malayi Intermediate filament tail domain containing protein 0.0117 0.0252 0.0917
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0156 0.2584
Leishmania major DNA polymerase eta, putative 0.002 0.0011 0.014
Echinococcus multilocularis importin subunit beta 1 0.0086 0.0176 0.0174
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0021 0.0067
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0257 0.0598 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0011 0.0016
Toxoplasma gondii HEAT repeat-containing protein 0.0016 0.0003 0.0006
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0156 0.2767
Echinococcus multilocularis lamin dm0 0.0117 0.0252 0.0249
Schistosoma mansoni thyroid hormone receptor 0.005 0.0087 0.0341
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0064 0.012 0.0117
Brugia malayi glutathione reductase 0.0047 0.0078 0.0284
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0226 0.042
Brugia malayi hypothetical protein 0.0184 0.0417 0.1519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0069
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.0168 0.2973
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0011 0.014
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.107 0.261 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0068 0.106
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0061
Schistosoma mansoni smad1 5 8 and 0.0077 0.0152 0.0602
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0153 0.0282
Toxoplasma gondii exonuclease III APE 0.0018 0.0008 0.0087
Echinococcus multilocularis survival motor neuron protein 1 0.048 0.1151 0.1149
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0029 0.0026
Brugia malayi conserved hypotetical protein 0.0024 0.0021 0.0078
Leishmania major hypothetical protein, conserved 0.0047 0.0078 0.1267
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0021 0.0044
Schistosoma mansoni hypothetical protein 0.018 0.0407 0.1626
Leishmania major hypothetical protein, conserved 0.0016 0.0003 0.0006
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0018 0.0008 0.001
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0087 0.0645
Loa Loa (eye worm) hypothetical protein 0.0037 0.0055 0.019
Toxoplasma gondii HEAT repeat-containing protein 0.0086 0.0176 0.292
Leishmania major hypothetical protein, conserved 0.0078 0.0156 0.2584
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0153 0.2454
Brugia malayi CHD4 protein 0.0021 0.0015 0.0053
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0092 0.019 0.0753
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0087 0.0198
Brugia malayi Smad1 0.0077 0.0152 0.0554
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0184 0.0417 0.0415
Mycobacterium ulcerans integral membrane protein 0.0018 0.0008 0.001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0153 0.0606
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0087 0.0308
Brugia malayi follicle stimulating hormone receptor 0.0485 0.1162 0.423
Schistosoma mansoni smad 0.0034 0.0047 0.018
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0109 0.0107
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0014 0.019
Echinococcus granulosus chromobox protein 1 0.0082 0.0164 0.0378
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0056 0.0102 0.0233
Loa Loa (eye worm) hypothetical protein 0.0132 0.0289 0.1042
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0153 0.0282
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0008 0.0288
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0055 0.0946
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.217 0.533 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0011 0.0136
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0053 0.0095 0.2212
Schistosoma mansoni hypothetical protein 0.0098 0.0205 0.0814
Loa Loa (eye worm) hypothetical protein 0.005 0.0087 0.0308
Brugia malayi hypothetical protein 0.0024 0.0021 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0462
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0087 0.0198
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0241 0.0558 1
Schistosoma mansoni ferritin 0.0017 0.0004 0.0004
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0064 0.012 0.6489
Schistosoma mansoni tar DNA-binding protein 0.0275 0.0644 0.2579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0034 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0061 0.0949
Plasmodium falciparum glutathione reductase 0.0047 0.0078 0.136
Onchocerca volvulus 0.0077 0.0153 0.1183
Echinococcus multilocularis ferritin 0.0017 0.0004 0.0001
Brugia malayi intermediate filament protein 0.0117 0.0252 0.0917
Loa Loa (eye worm) bromodomain containing protein 0.0054 0.0096 0.0338
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0078 0.0142
Loa Loa (eye worm) intermediate filament protein 0.0117 0.0252 0.0907
Brugia malayi Thioredoxin reductase 0.0047 0.0078 0.0284
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0086 0.0157
Brugia malayi nuclear hormone receptor 0.0024 0.0021 0.0078
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0063 0.0118 0.0418
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0007 0.0071
Loa Loa (eye worm) hypothetical protein 0.0037 0.0055 0.019
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0086 0.0157
Brugia malayi Bromodomain containing protein 0.0117 0.0251 0.0915
Loa Loa (eye worm) hypothetical protein 0.0046 0.0076 0.0265
Loa Loa (eye worm) hypothetical protein 0.0261 0.0609 0.2208
Schistosoma mansoni lipoxygenase 0.0138 0.0304 0.1213
Schistosoma mansoni ferritin light chain 0.0017 0.0004 0.0004
Schistosoma mansoni aldehyde dehydrogenase 0.0257 0.0598 0.2394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0068 0.106
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0014 0.019
Brugia malayi kap beta 3 protein 0.0016 0.0003 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0008 0.0085
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0078 0.136
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0021 0.0078
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0011 0.0462
Echinococcus multilocularis snurportin 1 0.0923 0.2245 0.2243
Schistosoma mansoni nuclear receptor 0.0024 0.0021 0.0076
Echinococcus granulosus peptidase Clp S14 family 0.0158 0.0353 0.0818
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0008 0.0094
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0084 0.1331
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0087 0.0318
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0109 0.0398
Echinococcus multilocularis mothers against decapentaplegic 6 0.0034 0.0047 0.0045
Echinococcus granulosus expressed protein 0.0017 0.0004 0.0002
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0011 0.0462
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0053 0.0095 0.5092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.0164 0.0651
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0021 0.0076
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0087 0.0308
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0078 0.0274
Schistosoma mansoni smad1 5 8 and 0.0077 0.0152 0.0602
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0087 0.0085
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0241 0.0558 1
Brugia malayi MH2 domain containing protein 0.1126 0.2748 1
Mycobacterium ulcerans hypothetical protein 0.0018 0.0008 0.001
Loa Loa (eye worm) latrophilin receptor protein 2 0.018 0.0407 0.1471
Schistosoma mansoni smad1 5 8 and 0.0077 0.0152 0.0602
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0011 0.0016
Brugia malayi hypothetical protein 0.0027 0.0029 0.0104
Onchocerca volvulus 0.0023 0.002 0.0089
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0153 0.0282
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0184 0.0417 0.0969
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0021 0.0044
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0068 0.3603
Echinococcus multilocularis mothers against decapentaplegic 2 0.0034 0.0047 0.0045
Schistosoma mansoni bromodomain containing protein 0.0195 0.0445 0.1779
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0093
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0153 0.0282
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0017 0.082
Loa Loa (eye worm) hypothetical protein 0.0115 0.0247 0.0888
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0011 0.0016
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0241 0.0558 0.2127
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0153 0.2454
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0226 0.042
Onchocerca volvulus 0.0098 0.0205 0.1609
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0061 0.0949
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0014 0.019
Schistosoma mansoni intermediate filament proteins 0.0117 0.0252 0.1003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0082 0.0164 0.0651
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0082 0.0164 0.0162
Brugia malayi nuclear receptor RXR 0.0024 0.0021 0.0078
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0089 0.0183 0.0727
Brugia malayi cytoplasmic intermediate filament protein 0.0063 0.0118 0.0428
Brugia malayi MH2 domain containing protein 0.0077 0.0152 0.0554
Entamoeba histolytica hypothetical protein 0.0184 0.0417 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0011 0.0462
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0462
Brugia malayi TAR-binding protein 0.0275 0.0644 0.2342
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0241 0.0558 0.9337
Echinococcus multilocularis thyroid hormone receptor alpha 0.005 0.0087 0.0085
Loa Loa (eye worm) hypothetical protein 0.0108 0.0229 0.0823
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0021 0.0078
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0256 0.0475
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0241 0.0558 1
Mycobacterium tuberculosis Conserved protein 0.0077 0.0153 0.0282
Entamoeba histolytica hypothetical protein 0.0184 0.0417 1
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0153 0.8325
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0462
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0462
Loa Loa (eye worm) hypothetical protein 0.0241 0.0558 0.2022
Schistosoma mansoni ran 0.0064 0.012 0.0472
Trichomonas vaginalis ferritin, putative 0.0017 0.0004 0.0017
Echinococcus multilocularis geminin 0.1021 0.2488 0.2486
Echinococcus granulosus caax prenyl protease 1 0.0066 0.0126 0.0288
Loa Loa (eye worm) MH1 domain-containing protein 0.0077 0.0152 0.0544
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0241 0.0558 0.0556
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0492 0.118 0.221
Entamoeba histolytica CAAX amino terminal protease family 0.0018 0.0008 0.0124
Onchocerca volvulus 0.0077 0.0153 0.1183
Schistosoma mansoni peptidase Clp (S14 family) 0.0241 0.0558 0.2235
Loa Loa (eye worm) hypothetical protein 0.0089 0.0183 0.0657
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0087 0.0318
Trichomonas vaginalis Importin beta-1 subunit, putative 0.007 0.0136 0.2174
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0008 0.0028
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.002 0.004
Loa Loa (eye worm) heterochromatin protein 1 0.0082 0.0164 0.0588
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0138 0.0304 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0041 0.0634
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0008 0.0018
Brugia malayi Probable ClpP-like protease 0.0241 0.0558 0.2031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0087 0.0198
Schistosoma mansoni thyroid hormone receptor 0.005 0.0087 0.0341
Onchocerca volvulus 0.0086 0.0175 0.1362
Schistosoma mansoni lamin 0.0117 0.0252 0.1003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0109 0.02
Schistosoma mansoni hypothetical protein 0.0474 0.1135 0.4558
Onchocerca volvulus 0.0036 0.0051 0.0348
Mycobacterium ulcerans hypothetical protein 0.0077 0.0153 0.0282
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0109 0.0429
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0011 0.004
Schistosoma mansoni glutaminase 0.0264 0.0616 0.2467
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0462
Leishmania major DNA polymerase kappa, putative 0.002 0.0011 0.014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0093
Loa Loa (eye worm) hypothetical protein 0.0037 0.0055 0.019
Loa Loa (eye worm) hypothetical protein 0.005 0.0087 0.0308
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0087 0.0198
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.048 0.1151 0.4183
Schistosoma mansoni cellular tumor antigen P53 0.0256 0.0595 0.2385
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.0004
Schistosoma mansoni rab6-interacting 0.0023 0.002 0.0069
Loa Loa (eye worm) MH2 domain-containing protein 0.0077 0.0152 0.0544
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0029 0.0104
Brugia malayi beta-lactamase family protein 0.0077 0.0153 0.0557
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0004 0.0026
Schistosoma mansoni apoferritin-2 0.0017 0.0004 0.0004
Schistosoma mansoni methyl-cpg binding protein mbd 0.0052 0.0091 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0087 0.0318
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0256 0.0475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0034 0.0508
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0029 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0075 0.1186
Onchocerca volvulus 0.0024 0.0021 0.0104
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0021 0.0015 0.0049
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0008 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0069 0.0266
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0011 0.0034
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0087 0.0645
Loa Loa (eye worm) glutathione reductase 0.0047 0.0078 0.0274
Echinococcus granulosus importin subunit beta 1 0.0086 0.0176 0.0406
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0021 0.0019
Schistosoma mansoni hypothetical protein 0.0923 0.2245 0.9022
Trichomonas vaginalis ran, putative 0.0064 0.012 0.1913
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0036 0.0556
Entamoeba histolytica CAAX prenyl protease, putative 0.0066 0.0126 0.297
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0153 0.0557
Schistosoma mansoni hypothetical protein 0.0047 0.0078 0.0303
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0087 0.0341
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0462
Toxoplasma gondii HEAT repeat-containing protein 0.0016 0.0003 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0048 0.0745
Onchocerca volvulus Huntingtin homolog 0.0261 0.0609 0.4923
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0064 0.012 0.6489
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0086 0.1409
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0056 0.0102 0.01
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.023 0.0532 0.1926
Mycobacterium leprae Probable lipase LipE 0.0077 0.0153 0.0573
Schistosoma mansoni hypothetical protein 0.0184 0.0417 0.1669
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0153 0.0351
Onchocerca volvulus Phospholipase A2 homolog 0.0512 0.1228 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0087 0.0085
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0257 0.0598 0.0595
Brugia malayi Phospholipase A2 family protein 0.0108 0.0229 0.0833
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0485 0.1162 0.4224
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0067
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.005 0.0089
Loa Loa (eye worm) CHromoDomain protein family member 0.0021 0.0015 0.0043
Onchocerca volvulus 0.005 0.0086 0.0637
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0021 0.0104
Schistosoma mansoni hypothetical protein 0.0388 0.0922 0.3699
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0087 0.0318
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0067
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0087 0.0341
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0004 0.0019
Schistosoma mansoni transcription factor LCR-F1 0.0184 0.0417 0.1669
Trypanosoma cruzi importin beta-1 subunit, putative 0.007 0.0136 0.7375
Entamoeba histolytica Ran family GTPase 0.0064 0.012 0.2821
Brugia malayi hypothetical protein 0.0261 0.0609 0.2217
Brugia malayi nuclear receptor RXR 0.0027 0.0029 0.0104
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0086 0.0318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0041 0.0621
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0011 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0061
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.018 0.0407 0.0404
Loa Loa (eye worm) hypothetical protein 0.0037 0.0055 0.019
Loa Loa (eye worm) transcription factor SMAD2 0.1126 0.2748 1
Mycobacterium ulcerans hypothetical protein 0.0018 0.0008 0.001
Brugia malayi nuclear hormone receptor 0.005 0.0087 0.0318
Toxoplasma gondii hypothetical protein 0.0083 0.0168 0.2775
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0006 0.0049
Echinococcus multilocularis tumor protein p63 0.1748 0.4285 0.4284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0087 0.0308
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.002 0.0307
Trypanosoma brucei CAAX amino terminal protease, putative 0.0089 0.0183 1
Trichomonas vaginalis set domain proteins, putative 0.023 0.053 0.8607
Loa Loa (eye worm) hypothetical protein 0.0054 0.0097 0.0342
Echinococcus granulosus FTZ F1 alpha 0.005 0.0087 0.0198
Leishmania major importin beta-1 subunit, putative 0.007 0.0136 0.2241
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0086 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0087 0.0318
Onchocerca volvulus 0.005 0.0087 0.0645
Schistosoma mansoni ap endonuclease 0.0018 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.005 0.0087 0.0308
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0011 0.0462
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0078 0.4178
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0043 0.0653
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0462
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0087 0.0318
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0256 0.0475
Trichomonas vaginalis importin beta-1, putative 0.007 0.0136 0.2174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0087 0.0198
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0008 0.0288
Schistosoma mansoni hypothetical protein 0.1021 0.2488 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0257 0.0598 0.1117
Brugia malayi MH1 domain containing protein 0.0077 0.0152 0.0554
Loa Loa (eye worm) hypothetical protein 0.0082 0.0164 0.0588
Loa Loa (eye worm) glutaminase 2 0.0264 0.0616 0.2233
Echinococcus granulosus smad 0.0077 0.0152 0.035
Loa Loa (eye worm) TAR-binding protein 0.0275 0.0644 0.2334
Loa Loa (eye worm) hypothetical protein 0.0077 0.0153 0.0547
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0008 0.0005
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0257 0.0598 0.1389
Loa Loa (eye worm) hypothetical protein 0.0388 0.0922 0.3348
Echinococcus granulosus tumor protein p63 0.1748 0.4285 1
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0089 0.0183 0.3038
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0011 0.004
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0153 0.2454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0034 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0061 0.0949
Schistosoma mansoni cpg binding protein 0.0041 0.0064 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0087 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0087 0.0318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0069
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0304
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0068 0.1095
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.023 0.0532 0.1935
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0087 0.0308
Brugia malayi Bromodomain containing protein 0.0231 0.0533 0.194
Brugia malayi hypothetical protein 0.0051 0.0088 0.0319
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0016 0.0003 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0041 0.0634
Schistosoma mansoni Smad4 0.0077 0.0152 0.0602
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0462
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0064 0.012 0.2112
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0168 0.2973
Schistosoma mansoni zinc finger protein 0.0047 0.0078 0.0303
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0087 0.0318
Schistosoma mansoni polycystin 1-related 0.0023 0.002 0.0069
Echinococcus granulosus GPCR family 2 0.018 0.0407 0.0943
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0021 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0087 0.0318
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0021 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0051 0.0792
Schistosoma mansoni aldehyde dehydrogenase 0.0257 0.0598 0.2394
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0008 0.0116
Echinococcus granulosus lamin dm0 0.0117 0.0252 0.0582
Onchocerca volvulus 0.0023 0.002 0.0089
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0092 0.019 0.0753
Brugia malayi glutaminase DH11.1 0.0264 0.0616 0.2241
Onchocerca volvulus Huntingtin homolog 0.0261 0.0609 0.4923
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0067
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0011 0.0008
Schistosoma mansoni zinc finger protein 0.0062 0.0115 0.0452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0034 0.051
Schistosoma mansoni rab6-interacting 0.0023 0.002 0.0069
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0184 0.0418 0.0969
Loa Loa (eye worm) hypothetical protein 0.0216 0.0496 0.1796
Schistosoma mansoni loxhd1 0.0023 0.002 0.0069
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0093
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0158 0.0353 0.0658
Loa Loa (eye worm) hypothetical protein 0.005 0.0087 0.0308
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0153 0.0151
Plasmodium falciparum protease, putative 0.0018 0.0008 0.0099
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0462
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0086 0.2014
Plasmodium vivax transportin, putative 0.0016 0.0003 0.0007
Brugia malayi MH1 domain containing protein 0.0042 0.0068 0.0246
Brugia malayi MH1 domain containing protein 0.0042 0.0068 0.0246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.0532 0.2129
Schistosoma mansoni chromobox protein 0.0082 0.0164 0.0651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0068 0.106
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0071 0.0137 0.0135
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0021 0.0044
Loa Loa (eye worm) MH2 domain-containing protein 0.1126 0.2748 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0064 0.012 0.0426
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.002 0.0017
Brugia malayi Pre-SET motif family protein 0.003 0.0036 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0034 0.051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.011 0.0234 0.0231
Echinococcus multilocularis Smad4 0.0077 0.0152 0.015
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0076 0.0548
Onchocerca volvulus 0.0256 0.0595 0.481
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0087 0.0085
Echinococcus granulosus Smad4 0.0077 0.0152 0.035
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0235
Echinococcus granulosus transportin 1 0.0016 0.0003 0.0001
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0021 0.0076
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0021 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0034 0.0508
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0089 0.0183 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.019 0.068
Schistosoma mansoni survival motor neuron protein 0.0098 0.0205 0.0814
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0226 0.042
Loa Loa (eye worm) DR-78 0.0024 0.0021 0.0067
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0071 0.0137 0.0542
Echinococcus granulosus translational activator gcn1 0.0016 0.0003 0.0001
Echinococcus granulosus mothers against decapentaplegic 2 0.0034 0.0047 0.0105
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0109 0.02
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0109 0.0249
Brugia malayi Calcitonin receptor-like protein seb-1 0.0567 0.1366 0.4971
Trichomonas vaginalis chromobox protein, putative 0.0049 0.0084 0.1331
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0008 0.0087
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0086 0.0157
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0086 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0068 0.106
Echinococcus multilocularis CAAX prenyl protease 2 0.0089 0.0183 0.0181
Brugia malayi AMP-binding enzyme family protein 0.005 0.0086 0.0315
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0087 0.0318
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.023 0.0532 0.0529
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0226 0.042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0008 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0011 0.0462
Brugia malayi ecdysone receptor 0.0024 0.0021 0.0078
Brugia malayi nuclear receptor NHR-88 0.0024 0.0021 0.0078
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0053 0.0095 0.2212
Brugia malayi hypothetical protein 0.0024 0.0021 0.0078
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0053 0.0095 0.037
Loa Loa (eye worm) hypothetical protein 0.005 0.0087 0.0308
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0158 0.0353 0.0658
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0257 0.0598 0.1117
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0156 0.2767
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.023 0.0532 0.2129
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0011 0.0462
Loa Loa (eye worm) hypothetical protein 0.0086 0.0176 0.0632
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0156 0.2767
Trypanosoma cruzi CAAX prenyl protease 1, putative 0.0066 0.0126 0.6832
Echinococcus multilocularis chromobox protein 1 0.0082 0.0164 0.0162
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0021 0.0044
Plasmodium vivax SET domain protein, putative 0.003 0.0036 0.0596
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0087 0.0341
Schistosoma mansoni lipoxygenase 0.0097 0.0201 0.08
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.011 0.0234 0.0539
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0008 0.001
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0087 0.0198
Loa Loa (eye worm) hypothetical protein 0.0512 0.1228 0.4463
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0118 0.042
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0078 0.0176
Onchocerca volvulus Phospholipase A2 homolog 0.0108 0.0229 0.1806
Loa Loa (eye worm) nuclear factor I 0.0042 0.0068 0.0235
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0008 0.0288
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0014 0.019
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0304
Schistosoma mansoni chromobox protein 0.0082 0.0164 0.0651
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0086 0.1409
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0087 0.0318
Plasmodium falciparum transportin 0.0016 0.0003 0.0007
Trypanosoma brucei unspecified product 0.002 0.0011 0.0462
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0011 0.0462
Loa Loa (eye worm) hypothetical protein 0.005 0.0087 0.0308
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0034 0.0047 0.0316
Trichomonas vaginalis Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase 0.0066 0.0126 0.2014
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0021 0.0019
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0241 0.0558 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0068 0.0235
Schistosoma mansoni tar DNA-binding protein 0.0275 0.0644 0.2579
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0008 0.0012
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0014 0.019
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0067
Echinococcus multilocularis expressed protein 0.0017 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0077 0.0153 0.0547
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0087 0.0341
Brugia malayi beta-lactamase family protein 0.0077 0.0153 0.0557
Schistosoma mansoni hypothetical protein 0.018 0.0407 0.1626
Loa Loa (eye worm) hypothetical protein 0.005 0.0087 0.0308
Leishmania major trypanothione reductase 0.0047 0.0078 0.1269
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0043 0.0653
Echinococcus granulosus GTP binding nuclear protein Ran 0.0064 0.012 0.0274
Schistosoma mansoni nuclear hormone receptor 0.005 0.0087 0.0341
Brugia malayi CAAX amino terminal protease family protein 0.0089 0.0183 0.0667
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0093
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0153 0.0282
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0025 0.124
Echinococcus multilocularis neuropeptide receptor 0.0188 0.0428 0.0426
Loa Loa (eye worm) hypothetical protein 0.0077 0.0153 0.0547
Echinococcus granulosus ferritin 0.0017 0.0004 0.0002
Mycobacterium tuberculosis Probable integral membrane protein 0.0018 0.0008 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0011 0.0462
Trypanosoma cruzi ISWI complex protein 0.0047 0.0078 0.417
Echinococcus multilocularis smad 0.0077 0.0152 0.015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.018 0.0407 0.148
Brugia malayi Pre-SET motif family protein 0.0202 0.0462 0.168
Brugia malayi Doublecortin family protein 0.0023 0.002 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0087 0.0308
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0067
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.018 0.0407 0.0404
Brugia malayi MH1 domain containing protein 0.0077 0.0152 0.0554
Trichomonas vaginalis chromobox protein, putative 0.0082 0.0164 0.2637
Entamoeba histolytica CAAX prenyl protease family 0.0089 0.0183 0.4352
Schistosoma mansoni cpg binding protein 0.0033 0.0045 0.017
Schistosoma mansoni lamin 0.0117 0.0252 0.1003
Brugia malayi Importin beta-1 subunit 0.0086 0.0176 0.0642
Brugia malayi mothers against decapentaplegic homolog 3 0.0034 0.0047 0.0172
Echinococcus multilocularis tar DNA binding protein 0.0275 0.0644 0.0641
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.0413 0.3316
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0053 0.0095 0.0092
Brugia malayi Trypsin family protein 0.0092 0.019 0.069
Onchocerca volvulus 0.0043 0.0069 0.0491
Echinococcus multilocularis GPCR, family 2 0.018 0.0407 0.0404
Echinococcus granulosus methyl CpG binding domain protein 2 0.0052 0.0091 0.0207
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0011 0.0462
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0029 0.0061
Schistosoma mansoni Smad4 0.0034 0.0047 0.018
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0061 0.0978
Schistosoma mansoni importin beta-1 0.0086 0.0176 0.0699
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0004 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.023 0.0532 0.1236
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0089 0.0183 1
Brugia malayi Peptidase family M48 containing protein 0.0066 0.0126 0.0459
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0011 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0087 0.0308
Entamoeba histolytica CAAX amino terminal protease family 0.0018 0.0008 0.0124
Schistosoma mansoni hypothetical protein 0.018 0.0407 0.1626
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0021 0.0076
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0021 0.0067
Mycobacterium ulcerans hypothetical protein 0.005 0.0086 0.0157
Echinococcus granulosus lamin 0.0117 0.0252 0.0582
Echinococcus granulosus cpg binding protein 0.0041 0.0064 0.0143
Echinococcus granulosus TGF beta signal transducer SmadC 0.0077 0.0152 0.035
Schistosoma mansoni coup transcription factor 0.005 0.0087 0.0341
Echinococcus granulosus intermediate filament protein 0.0117 0.0252 0.0582
Schistosoma mansoni Smad4 0.0034 0.0047 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0034 0.0508
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0021 0.0019
Echinococcus granulosus survival motor neuron protein 1 0.048 0.1151 0.2682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0069
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0008 0.0094
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0029 0.0093
Toxoplasma gondii hypothetical protein 0.0018 0.0008 0.0093
Giardia lamblia GTOR 0.0053 0.0095 0.5092
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0007 0.0025
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0021 0.0044
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0064 0.012 0.2112
Onchocerca volvulus 0.0024 0.0021 0.0104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0014 0.019
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0153 0.2709
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0053 0.0095 0.1547
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0053 0.0095 0.0215
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0086 0.0157
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0093
Loa Loa (eye worm) doublecortin family protein 0.0023 0.002 0.0061
Onchocerca volvulus 0.023 0.053 0.4278
Brugia malayi ecdysteroid receptor 0.005 0.0087 0.0318
Plasmodium falciparum importin beta, putative 0.0086 0.0176 0.3128
Entamoeba histolytica hypothetical protein 0.007 0.0136 0.3207
Loa Loa (eye worm) hypothetical protein 0.0078 0.0156 0.0559
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0047 0.0162
Toxoplasma gondii ABC1 family protein 0.0077 0.0153 0.253
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0021 0.0019
Echinococcus multilocularis dnaJ subfamily B 0.0474 0.1135 0.1133
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0086 0.0157
Loa Loa (eye worm) hypothetical protein 0.0117 0.0252 0.0907
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0228
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0011 0.0136
Loa Loa (eye worm) hypothetical protein 0.0117 0.0252 0.0907
Brugia malayi hypothetical protein 0.0023 0.002 0.0072
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0086 0.0157
Loa Loa (eye worm) hypothetical protein 0.0092 0.019 0.068
Echinococcus multilocularis mothers against decapentaplegic 5 0.0077 0.0152 0.015
Schistosoma mansoni methyl-cpg binding protein mbd 0.0052 0.0091 0.0357
Entamoeba histolytica hypothetical protein 0.0184 0.0417 1
Toxoplasma gondii CAAX metallo endopeptidase 0.0066 0.0126 0.2076
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0226 0.042
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0055 0.0099
Echinococcus multilocularis caax prenyl protease 1 0.0066 0.0126 0.0124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.005 0.0089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.005 0.0089
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0087 0.0085
Mycobacterium ulcerans beta-lactamase 0.0077 0.0153 0.0282
Onchocerca volvulus 0.0092 0.019 0.1483
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0087 0.0341
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0156 0.8504
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0086 0.0157
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.0139 0.2294
Echinococcus granulosus CAAX prenyl protease 2 0.0089 0.0183 0.0422
Schistosoma mansoni DNA polymerase eta 0.002 0.0011 0.0034
Onchocerca volvulus 0.0117 0.0252 0.1994
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0053 0.0095 0.5092
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0087 0.0198
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0156 0.8504
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0087 0.0085
Loa Loa (eye worm) peptidase family M48 containing protein 0.0066 0.0126 0.0448
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0087 0.0085
Echinococcus granulosus mothers against decapentaplegic 6 0.0034 0.0047 0.0105
Schistosoma mansoni ferritin 0.0017 0.0004 0.0004
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0235
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0049 0.0084 0.0619
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0011 0.0034
Schistosoma mansoni hypothetical protein 0.0035 0.0049 0.0189
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0004 0.0002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0021 0.0019
Echinococcus granulosus zinc finger protein 0.0062 0.0115 0.0262
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0077 0.0152 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0095 0.1501
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0095 0.0344
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.002 0.004
Echinococcus multilocularis chromobox protein 1 0.0082 0.0164 0.0162
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0008 0.0094
Echinococcus granulosus mothers against decapentaplegic 5 0.0077 0.0152 0.035
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0153 0.0573
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0241 0.0558 0.1043
Brugia malayi MH2 domain containing protein 0.0077 0.0152 0.0554
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0086 0.1409
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0055 0.0946
Brugia malayi PHD-finger family protein 0.0078 0.0155 0.0565
Schistosoma mansoni importin-beta 2 0.0016 0.0003 0.0002
Loa Loa (eye worm) glutaminase 0.0264 0.0616 0.2233
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0304
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.014 0.0552
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0067
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0067
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0241 0.0558 0.1297
Trichomonas vaginalis glutaminase, putative 0.0264 0.0616 1
Brugia malayi latrophilin 2 splice variant baaae 0.0388 0.0922 0.3355
Schistosoma mansoni hypothetical protein 0.018 0.0407 0.1626
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0053 0.0095 0.5092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0067
Echinococcus multilocularis dna polymerase kappa 0.002 0.0011 0.0008
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0087 0.0318
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0153 0.8325
Schistosoma mansoni ap endonuclease 0.0018 0.0008 0.0021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.018 0.0407 0.0943
Entamoeba histolytica hypothetical protein 0.0184 0.0417 1
Brugia malayi Heterochromatin protein 1 0.0082 0.0164 0.0598
Loa Loa (eye worm) hypothetical protein 0.0036 0.0051 0.0176
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0275 0.0644 0.2334
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.023 0.0532 0.0529
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0029 0.0104
Loa Loa (eye worm) hypothetical protein 0.0077 0.0153 0.0547
Trypanosoma brucei importin beta-1 subunit, putative 0.0086 0.0176 0.9611
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0021 0.0076
Toxoplasma gondii aldehyde dehydrogenase 0.0257 0.0598 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0064 0.012 0.6489
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.002 0.0307
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0153 0.0606
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0007 0.0014
Loa Loa (eye worm) hypothetical protein 0.0034 0.0047 0.0162
Loa Loa (eye worm) hypothetical protein 0.0124 0.027 0.0972
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0087 0.0085
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0071
Brugia malayi chromobox protein homolog 3 0.0046 0.0076 0.0275
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0138 0.0304 0.0302
Mycobacterium tuberculosis Conserved protein 0.0077 0.0153 0.0282
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0087 0.0085
Brugia malayi RNA recognition motif domain containing protein 0.0275 0.0644 0.2342
Loa Loa (eye worm) hypothetical protein 0.0261 0.0609 0.2208
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0077 0.0152 0.0602
Plasmodium vivax protease, putative 0.0018 0.0008 0.0099
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0256 0.0967
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0053 0.0095 0.1547
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0087 0.0341
Schistosoma mansoni zinc finger protein 0.0024 0.0021 0.0076
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0016 0.0003 0.0021
Brugia malayi hypothetical protein 0.0078 0.0156 0.0569
Loa Loa (eye worm) beta-lactamase 0.0077 0.0153 0.0547
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0004 0.0019
Echinococcus granulosus RUN 0.0023 0.002 0.004
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0011 0.0192
Echinococcus granulosus dna polymerase kappa 0.002 0.0011 0.0019
Brugia malayi hypothetical protein 0.048 0.1151 0.4189
Schistosoma mansoni apoferritin-2 0.0017 0.0004 0.0004
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0086 0.0318
Mycobacterium ulcerans aldehyde dehydrogenase 0.0257 0.0598 0.1117
Brugia malayi AMP-binding enzyme family protein 0.005 0.0086 0.0315
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0055 0.0099
Echinococcus multilocularis peptidase Clp (S14 family) 0.0158 0.0353 0.035
Brugia malayi hypothetical protein 0.0023 0.002 0.0072
Schistosoma mansoni nuclear receptor 0.0024 0.0021 0.0076
Schistosoma mansoni ferritin light chain 0.0017 0.0004 0.0004
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0241 0.0558 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0153 0.0547
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0011 0.0462
Echinococcus multilocularis musashi 0.0117 0.0252 0.0249
Brugia malayi nuclear receptor NHR-88 0.005 0.0087 0.0318
Schistosoma mansoni smad 0.0077 0.0152 0.0602
Trypanosoma cruzi metallo- peptidase, Clan M- Family M48 0.0066 0.0126 0.6832
Onchocerca volvulus 0.0117 0.0252 0.1994
Echinococcus granulosus dna polymerase eta 0.002 0.0011 0.0019
Mycobacterium tuberculosis Probable reductase 0.0107 0.0226 0.042
Onchocerca volvulus 0.0077 0.0153 0.1183
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0095 0.0334
Loa Loa (eye worm) hypothetical protein 0.0024 0.0021 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0275 0.0644 0.2579
Leishmania major GTP-binding protein, putative 0.0064 0.012 0.1972
Toxoplasma gondii CAAX amino terminal protease family protein 0.0018 0.0008 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0041 0.0634
Echinococcus multilocularis RUN 0.0023 0.002 0.0017
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0153 0.0282
Echinococcus multilocularis cpg binding protein 0.0041 0.0064 0.0061
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0021 0.0078
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0156 0.8504
Brugia malayi MH2 domain containing protein 0.0034 0.0047 0.0172
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0567 0.1366 0.4966
Echinococcus multilocularis G protein coupled receptor 139 0.0188 0.0428 0.0426
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0089 0.0183 0.2948
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0036 0.0033
Schistosoma mansoni ferritin 0.0017 0.0004 0.0004
Trypanosoma brucei ISWI complex protein 0.0047 0.0078 0.417
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0055 0.0946
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0005 0.0017
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0158 0.0353 0.134
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0004 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0041 0.0621
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0087 0.0198
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0089 0.0183 0.0727
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0061 0.0949
Loa Loa (eye worm) hypothetical protein 0.005 0.0087 0.0308
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0021 0.0015 0.0012
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0021 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0153 0.8325
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0007 0.0235
Echinococcus multilocularis lamin 0.0117 0.0252 0.0249
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0003 0.0009
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0052 0.0091 0.0089
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0068 0.3603
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0045 0.0153
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.002 0.004
Echinococcus granulosus geminin 0.1021 0.2488 0.5803
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0064 0.012 0.0436
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.018 0.0407 0.0943
Leishmania major CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48 0.0066 0.0126 0.2076
Brugia malayi AMP-binding enzyme family protein 0.005 0.0086 0.0315
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0007 0.001
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.002 0.0017
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0064 0.012 0.1972
Echinococcus granulosus chromobox protein 1 0.0082 0.0164 0.0378
Mycobacterium tuberculosis Conserved protein 0.0077 0.0153 0.0282
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0109 0.02
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0007 0.0069
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0049 0.0047
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0078 0.0076
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0086 0.2014

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antimalarial activity as cures against multidrug-resistant Plasmodium yoelii nigeriensis in Swiss mice (Mus musculus) at 96 mg/kg peroral dose for 4 days ChEMBL. 19006381
Activity (functional) = 36.74 % Antimalarial activity as reduced parasitaemia against multidrug-resistant Plasmodium yoelii nigeriensis in Swiss mice (Mus musculus) at 96 mg/kg peroral dose for 4 days ChEMBL. 19006381
Survival (functional) = 7.2 day Antimalarial activity as survival time against multidrug-resistant Plasmodium yoelii nigeriensis in Swiss mice (Mus musculus) at 96 mg/kg peroral dose for 4 days ChEMBL. 19006381

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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