TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 404.498 | Formula: C26H28O4
H donors: 0 H acceptors: 0 LogP: 6.15 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: C=C(c1ccc(cc1)Oc1ccccc1)C1COC2(OO1)C1CC3CC2CC(C1)C3
InChi: 1S/C26H28O4/c1-17(20-7-9-24(10-8-20)28-23-5-3-2-4-6-23)25-16-27-26(30-29-25)21-12-18-11-19(14-21)15-22(26)13-18/h2-10,18-19,21-22,25H,1,11-16H2
InChiKey: CWUFKNVEXCMGEE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0092	0.019	0.068
Trypanosoma cruzi	CAAX prenyl protease 2, putative	0.0089	0.0183	1
Brugia malayi	Nuclear hormone receptor E75	0.0024	0.0021	0.0078
Echinococcus granulosus	transportin 1	0.0016	0.0003	0.0001
Schistosoma mansoni	nuclear receptor nhr-48	0.0024	0.0021	0.0076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0034	0.0508
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.005	0.0087	0.0085
Echinococcus granulosus	Smad4	0.0077	0.0152	0.035
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0018	0.0007	0.0235
Onchocerca volvulus		0.0256	0.0595	0.481
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0046	0.0076	0.0548
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0034	0.051
Brugia malayi	Pre-SET motif family protein	0.003	0.0036	0.013
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.002	0.0017
Echinococcus multilocularis	Smad4	0.0077	0.0152	0.015
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.011	0.0234	0.0231
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0071	0.0137	0.0135
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0068	0.106
Loa Loa (eye worm)	MH2 domain-containing protein	0.1126	0.2748	1
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0024	0.0021	0.0044
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0064	0.012	0.0426
Entamoeba histolytica	acyl-CoA synthetase, putative	0.005	0.0086	0.2014
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Schistosoma mansoni	chromobox protein	0.0082	0.0164	0.0651
Brugia malayi	MH1 domain containing protein	0.0042	0.0068	0.0246
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.023	0.0532	0.2129
Plasmodium vivax	transportin, putative	0.0016	0.0003	0.0007
Brugia malayi	MH1 domain containing protein	0.0042	0.0068	0.0246
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0158	0.0353	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0029	0.0093
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0077	0.0153	0.0151
Plasmodium falciparum	protease, putative	0.0018	0.0008	0.0099
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.0308
Schistosoma mansoni	loxhd1	0.0023	0.002	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0216	0.0496	0.1796
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0034	0.051
Schistosoma mansoni	rab6-interacting	0.0023	0.002	0.0069
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0184	0.0418	0.0969
Brugia malayi	glutaminase DH11.1	0.0264	0.0616	0.2241
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0067
Onchocerca volvulus	Huntingtin homolog	0.0261	0.0609	0.4923
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0092	0.019	0.0753
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0011	0.0008
Schistosoma mansoni	zinc finger protein	0.0062	0.0115	0.0452
Schistosoma mansoni	aldehyde dehydrogenase	0.0257	0.0598	0.2394
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0008	0.0116
Onchocerca volvulus		0.0023	0.002	0.0089
Echinococcus granulosus	lamin dm0	0.0117	0.0252	0.0582
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0024	0.0021	0.0044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0051	0.0792
Loa Loa (eye worm)	nuclear hormone receptor	0.0024	0.0021	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.005	0.0087	0.0318
Schistosoma mansoni	polycystin 1-related	0.0023	0.002	0.0069
Echinococcus granulosus	GPCR family 2	0.018	0.0407	0.0943
Schistosoma mansoni	zinc finger protein	0.0047	0.0078	0.0303
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.005	0.0087	0.0318
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Schistosoma mansoni	Smad4	0.0077	0.0152	0.0602
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0168	0.2973
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0064	0.012	0.2112
Brugia malayi	Bromodomain containing protein	0.0231	0.0533	0.194
Trypanosoma brucei	ULK family serine/threonine-protein kinase, putative	0.0016	0.0003	0.0021
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0041	0.0634
Brugia malayi	hypothetical protein	0.0051	0.0088	0.0319
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.0068	0.1095
Loa Loa (eye worm)	steroid hormone receptor	0.005	0.0087	0.0308
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.023	0.0532	0.1935
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0061	0.0949
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0304
Schistosoma mansoni	cpg binding protein	0.0041	0.0064	0.0247
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.005	0.0087	0.0318
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.005	0.0087	0.0318
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0007	0.0069
Leishmania major	CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48)	0.0089	0.0183	0.3038
Echinococcus granulosus	tumor protein p63	0.1748	0.4285	1
Loa Loa (eye worm)	hypothetical protein	0.0388	0.0922	0.3348
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0034	0.051
Trichomonas vaginalis	penicillin-binding protein, putative	0.0077	0.0153	0.2454
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0011	0.004
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0008	0.0005
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0257	0.0598	0.1389
Loa Loa (eye worm)	TAR-binding protein	0.0275	0.0644	0.2334
Echinococcus granulosus	smad	0.0077	0.0152	0.035
Loa Loa (eye worm)	glutaminase 2	0.0264	0.0616	0.2233
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0153	0.0547
Brugia malayi	MH1 domain containing protein	0.0077	0.0152	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0164	0.0588
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0257	0.0598	0.1117
Trichomonas vaginalis	importin beta-1, putative	0.007	0.0136	0.2174
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.005	0.0087	0.0198
Schistosoma mansoni	hypothetical protein	0.1021	0.2488	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0008	0.0288
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Mycobacterium tuberculosis	Probable oxidoreductase	0.0118	0.0256	0.0475
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.005	0.0087	0.0318
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0011	0.0462
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0078	0.4178
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0043	0.0653
Onchocerca volvulus		0.005	0.0087	0.0645
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.005	0.0086	0.0157
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.005	0.0087	0.0318
Leishmania major	importin beta-1 subunit, putative	0.007	0.0136	0.2241
Schistosoma mansoni	ap endonuclease	0.0018	0.0008	0.0021
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0097	0.0342
Echinococcus granulosus	FTZ F1 alpha	0.005	0.0087	0.0198
Plasmodium falciparum	LCCL domain-containing protein	0.0023	0.002	0.0307
Trichomonas vaginalis	set domain proteins, putative	0.023	0.053	0.8607
Trypanosoma brucei	CAAX amino terminal protease, putative	0.0089	0.0183	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.0061	0.0978
Schistosoma mansoni	Smad4	0.0034	0.0047	0.018
Schistosoma mansoni	importin beta-1	0.0086	0.0176	0.0699
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0052	0.0091	0.0207
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0027	0.0029	0.0061
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Echinococcus multilocularis	GPCR, family 2	0.018	0.0407	0.0404
Onchocerca volvulus		0.0043	0.0069	0.0491
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0053	0.0095	0.0092
Brugia malayi	Trypsin family protein	0.0092	0.019	0.069
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0182	0.0413	0.3316
Brugia malayi	mothers against decapentaplegic homolog 3	0.0034	0.0047	0.0172
Brugia malayi	Importin beta-1 subunit	0.0086	0.0176	0.0642
Schistosoma mansoni	lamin	0.0117	0.0252	0.1003
Echinococcus multilocularis	tar DNA binding protein	0.0275	0.0644	0.0641
Entamoeba histolytica	CAAX prenyl protease family	0.0089	0.0183	0.4352
Schistosoma mansoni	cpg binding protein	0.0033	0.0045	0.017
Brugia malayi	MH1 domain containing protein	0.0077	0.0152	0.0554
Brugia malayi	Doublecortin family protein	0.0023	0.002	0.0072
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.018	0.0407	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0067
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.005	0.0087	0.0308
Trichomonas vaginalis	chromobox protein, putative	0.0082	0.0164	0.2637
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.018	0.0407	0.148
Echinococcus multilocularis	smad	0.0077	0.0152	0.015
Trypanosoma cruzi	ISWI complex protein	0.0047	0.0078	0.417
Brugia malayi	Pre-SET motif family protein	0.0202	0.0462	0.168
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Echinococcus multilocularis	neuropeptide receptor	0.0188	0.0428	0.0426
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0153	0.0547
Mycobacterium tuberculosis	Probable integral membrane protein	0.0018	0.0008	0.001
Echinococcus granulosus	ferritin	0.0017	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0029	0.0093
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0077	0.0153	0.0282
Brugia malayi	CAAX amino terminal protease family protein	0.0089	0.0183	0.0667
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0025	0.0025	0.124
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0064	0.012	0.0274
Schistosoma mansoni	nuclear hormone receptor	0.005	0.0087	0.0341
Leishmania major	trypanothione reductase	0.0047	0.0078	0.1269
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0043	0.0653
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.0308
Schistosoma mansoni	hypothetical protein	0.018	0.0407	0.1626
Brugia malayi	beta-lactamase family protein	0.0077	0.0153	0.0557
Echinococcus multilocularis	expressed protein	0.0017	0.0004	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0153	0.0547
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0067
Schistosoma mansoni	RAR-like nuclear receptor	0.005	0.0087	0.0341
Echinococcus multilocularis	nuclear receptor nhr 48	0.0024	0.0021	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0068	0.0235
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0241	0.0558	1
Trichomonas vaginalis	Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase	0.0066	0.0126	0.2014
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0014	0.019
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0008	0.0012
Schistosoma mansoni	tar DNA-binding protein	0.0275	0.0644	0.2579
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.005	0.0087	0.0318
Plasmodium falciparum	transportin	0.0016	0.0003	0.0007
Schistosoma mansoni	chromobox protein	0.0082	0.0164	0.0651
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0304
Leishmania major	4-coumarate:coa ligase-like protein	0.005	0.0086	0.1409
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.0308
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0034	0.0047	0.0316
Trypanosoma brucei	unspecified product	0.002	0.0011	0.0462
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0011	0.0462
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0021	0.0014	0.019
Onchocerca volvulus	Phospholipase A2 homolog	0.0108	0.0229	0.1806
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0008	0.0288
Loa Loa (eye worm)	nuclear factor I	0.0042	0.0068	0.0235
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0078	0.0176
Schistosoma mansoni	lipoxygenase	0.0097	0.0201	0.08
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.005	0.0087	0.0341
Loa Loa (eye worm)	PHD-finger family protein	0.0063	0.0118	0.042
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0008	0.001
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.011	0.0234	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0512	0.1228	0.4463
Echinococcus granulosus	ecdysone induced protein 78C	0.005	0.0087	0.0198
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0011	0.0462
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.023	0.0532	0.2129
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0176	0.0632
Echinococcus granulosus	nuclear receptor nhr 48	0.0024	0.0021	0.0044
Echinococcus multilocularis	chromobox protein 1	0.0082	0.0164	0.0162
Plasmodium falciparum	ataxin-2 like protein, putative	0.0078	0.0156	0.2767
Plasmodium vivax	SET domain protein, putative	0.003	0.0036	0.0596
Trypanosoma cruzi	CAAX prenyl protease 1, putative	0.0066	0.0126	0.6832
Plasmodium falciparum	ataxin-2 like protein, putative	0.0078	0.0156	0.2767
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.0308
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0257	0.0598	0.1117
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0158	0.0353	0.0658
Brugia malayi	hypothetical protein	0.0024	0.0021	0.0078
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0053	0.0095	0.037
Brugia malayi	nuclear receptor NHR-88	0.0024	0.0021	0.0078
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0053	0.0095	0.2212
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0018	0.0008	0.001
Brugia malayi	ecdysone receptor	0.0024	0.0021	0.0078
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0068	0.106
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0107	0.0226	0.042
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.023	0.0532	0.0529
Brugia malayi	Nuclear hormone receptor-like 1	0.005	0.0087	0.0318
Echinococcus multilocularis	CAAX prenyl protease 2	0.0089	0.0183	0.0181
Brugia malayi	AMP-binding enzyme family protein	0.005	0.0086	0.0315
Mycobacterium ulcerans	acyl-CoA synthetase	0.005	0.0086	0.0157
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.0109	0.0249
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0059	0.0109	0.02
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0008	0.0087
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.005	0.0086	0.0157
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0567	0.1366	0.4971
Trichomonas vaginalis	chromobox protein, putative	0.0049	0.0084	0.1331
Loa Loa (eye worm)	DR-78	0.0024	0.0021	0.0067
Echinococcus granulosus	translational activator gcn1	0.0016	0.0003	0.0001
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0071	0.0137	0.0542
Echinococcus granulosus	mothers against decapentaplegic 2	0.0034	0.0047	0.0105
Schistosoma mansoni	survival motor neuron protein	0.0098	0.0205	0.0814
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0107	0.0226	0.042
Brugia malayi	Heterochromatin protein 1	0.0082	0.0164	0.0598
Entamoeba histolytica	hypothetical protein	0.0184	0.0417	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.023	0.0532	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0051	0.0176
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0275	0.0644	0.2334
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.018	0.0407	0.0943
Schistosoma mansoni	ap endonuclease	0.0018	0.0008	0.0021
Schistosoma mansoni	hypothetical protein	0.018	0.0407	0.1626
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0053	0.0095	0.5092
Trichomonas vaginalis	glutaminase, putative	0.0264	0.0616	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0388	0.0922	0.3355
Brugia malayi	photoreceptor-specific nuclear receptor	0.005	0.0087	0.0318
Trypanosoma cruzi	hypothetical protein, conserved	0.0077	0.0153	0.8325
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0067
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0011	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0067
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0241	0.0558	0.1297
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0067
Loa Loa (eye worm)	glutaminase	0.0264	0.0616	0.2233
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0072	0.014	0.0552
Loa Loa (eye worm)	hypothetical protein	0.005	0.0086	0.0304
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0037	0.0055	0.0946
Schistosoma mansoni	importin-beta 2	0.0016	0.0003	0.0002
Brugia malayi	PHD-finger family protein	0.0078	0.0155	0.0565
Echinococcus granulosus	mothers against decapentaplegic 5	0.0077	0.0152	0.035
Mycobacterium leprae	conserved hypothetical protein	0.0077	0.0153	0.0573
Echinococcus multilocularis	chromobox protein 1	0.0082	0.0164	0.0162
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0008	0.0094
Brugia malayi	MH2 domain containing protein	0.0077	0.0152	0.0554
Leishmania major	4-coumarate:coa ligase-like protein	0.005	0.0086	0.1409
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0241	0.0558	0.1043
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.0095	0.1501
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0053	0.0095	0.0344
Echinococcus granulosus	Polycystic kidney disease protein	0.0023	0.002	0.004
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0077	0.0152	0.015
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0024	0.0021	0.0019
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0017	0.0004	0.0002
Schistosoma mansoni	hypothetical protein	0.0035	0.0049	0.0189
Echinococcus granulosus	zinc finger protein	0.0062	0.0115	0.0262
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0007	0.0235
Schistosoma mansoni	ferritin	0.0017	0.0004	0.0004
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0049	0.0084	0.0619
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0011	0.0034
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.005	0.0087	0.0198
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0053	0.0095	0.5092
Echinococcus multilocularis	FTZ F1 alpha	0.005	0.0087	0.0085
Echinococcus granulosus	mothers against decapentaplegic 6	0.0034	0.0047	0.0105
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.005	0.0087	0.0085
Loa Loa (eye worm)	peptidase family M48 containing protein	0.0066	0.0126	0.0448
Trypanosoma brucei	PAB1-binding protein , putative	0.0078	0.0156	0.8504
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.005	0.0087	0.0341
Onchocerca volvulus		0.0092	0.019	0.1483
Trypanosoma cruzi	PAB1-binding protein , putative	0.0078	0.0156	0.8504
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.005	0.0086	0.0157
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0071	0.0139	0.2294
Echinococcus granulosus	CAAX prenyl protease 2	0.0089	0.0183	0.0422
Onchocerca volvulus		0.0117	0.0252	0.1994
Schistosoma mansoni	DNA polymerase eta	0.002	0.0011	0.0034
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.005	0.0087	0.0085
Mycobacterium ulcerans	beta-lactamase	0.0077	0.0153	0.0282
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0107	0.0226	0.042
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0037	0.0055	0.0099
Toxoplasma gondii	CAAX metallo endopeptidase	0.0066	0.0126	0.2076
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0077	0.0152	0.015
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0052	0.0091	0.0357
Entamoeba histolytica	hypothetical protein	0.0184	0.0417	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.005	0.0089
Echinococcus multilocularis	caax prenyl protease 1	0.0066	0.0126	0.0124
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.005	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0092	0.019	0.068
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0011	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0252	0.0907
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0017	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0117	0.0252	0.0907
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0086	0.0157
Brugia malayi	hypothetical protein	0.0023	0.002	0.0072
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.005	0.0086	0.0157
Echinococcus multilocularis	dnaJ subfamily B	0.0474	0.1135	0.1133
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0024	0.0021	0.0019
Toxoplasma gondii	ABC1 family protein	0.0077	0.0153	0.253
Loa Loa (eye worm)	MH1 domain-containing protein	0.0034	0.0047	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0156	0.0559
Plasmodium falciparum	importin beta, putative	0.0086	0.0176	0.3128
Brugia malayi	ecdysteroid receptor	0.005	0.0087	0.0318
Entamoeba histolytica	hypothetical protein	0.007	0.0136	0.3207
Onchocerca volvulus		0.023	0.053	0.4278
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0029	0.0093
Mycobacterium ulcerans	acyl-CoA synthetase	0.005	0.0086	0.0157
Loa Loa (eye worm)	doublecortin family protein	0.0023	0.002	0.0061
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0064	0.012	0.2112
Onchocerca volvulus		0.0024	0.0021	0.0104
Echinococcus granulosus	thyroid hormone receptor alpha	0.0024	0.0021	0.0044
Plasmodium vivax	hypothetical protein, conserved	0.0077	0.0153	0.2709
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0053	0.0095	0.0215
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0053	0.0095	0.1547
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0014	0.019
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0027	0.0029	0.0093
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0007	0.0025
Toxoplasma gondii	hypothetical protein	0.0018	0.0008	0.0093
Giardia lamblia	GTOR	0.0053	0.0095	0.5092
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0024	0.0021	0.0019
Echinococcus granulosus	survival motor neuron protein 1	0.048	0.1151	0.2682
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0008	0.0094
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0007	0.0069
Echinococcus granulosus	intermediate filament protein	0.0117	0.0252	0.0582
Schistosoma mansoni	Smad4	0.0034	0.0047	0.018
Schistosoma mansoni	coup transcription factor	0.005	0.0087	0.0341
Echinococcus granulosus	lamin	0.0117	0.0252	0.0582
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0077	0.0152	0.035
Echinococcus granulosus	cpg binding protein	0.0041	0.0064	0.0143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0034	0.0508
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.005	0.0087	0.0308
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0011	0.0019
Brugia malayi	Peptidase family M48 containing protein	0.0066	0.0126	0.0459
Mycobacterium ulcerans	hypothetical protein	0.005	0.0086	0.0157
Schistosoma mansoni	nuclear hormone receptor	0.0024	0.0021	0.0076
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0024	0.0021	0.0067
Entamoeba histolytica	CAAX amino terminal protease family	0.0018	0.0008	0.0124
Schistosoma mansoni	hypothetical protein	0.018	0.0407	0.1626
Mycobacterium ulcerans	bacterioferritin BfrA	0.0017	0.0004	0.0002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.023	0.0532	0.1236
Trypanosoma cruzi	peptidase with unknown catalytic mechanism (family U48)	0.0089	0.0183	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.005	0.0086	0.2014
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0078	0.0076
Echinococcus granulosus	chromobox protein 1	0.0082	0.0164	0.0378
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.0109	0.02
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0064	0.012	0.1972
Mycobacterium tuberculosis	Conserved protein	0.0077	0.0153	0.0282
Echinococcus multilocularis	Polycystic kidney disease protein	0.0023	0.002	0.0017
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0035	0.0049	0.0047
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0007	0.0069
Leishmania major	CAAX prenyl protease 1, putative,metallo-peptidase, Clan M-, Family M48	0.0066	0.0126	0.2076
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.018	0.0407	0.0943
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0064	0.012	0.0436
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0045	0.0153
Echinococcus granulosus	geminin	0.1021	0.2488	0.5803
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.002	0.004
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0007	0.001
Brugia malayi	AMP-binding enzyme family protein	0.005	0.0086	0.0315
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.0068	0.3603
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0003	0.0009
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0052	0.0091	0.0089
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0021	0.0015	0.0012
Brugia malayi	orphan nuclear receptor NR2E1	0.0024	0.0021	0.0078
Echinococcus multilocularis	lamin	0.0117	0.0252	0.0249
Trypanosoma cruzi	hypothetical protein, conserved	0.0077	0.0153	0.8325
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0007	0.0235
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.0308
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0061	0.0949
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0041	0.0621
Mycobacterium ulcerans	bacterioferritin BfrB	0.0017	0.0004	0.0002
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0158	0.0353	0.134
Brugia malayi	F/Y-rich N-terminus family protein	0.0017	0.0005	0.0017
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0089	0.0183	0.0727
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.005	0.0087	0.0198
Trichomonas vaginalis	Clan U, family U48, CaaX prenyl peptidase 2-like	0.0089	0.0183	0.2948
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0036	0.0033
Echinococcus multilocularis	G protein coupled receptor 139	0.0188	0.0428	0.0426
Plasmodium falciparum	acyl-CoA synthetase	0.0037	0.0055	0.0946
Trypanosoma brucei	ISWI complex protein	0.0047	0.0078	0.417
Schistosoma mansoni	ferritin	0.0017	0.0004	0.0004
Brugia malayi	MH2 domain containing protein	0.0034	0.0047	0.0172
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0567	0.1366	0.4966
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0024	0.0021	0.0078
Trypanosoma cruzi	PAB1-binding protein , putative	0.0078	0.0156	0.8504
Mycobacterium tuberculosis	Probable hydrolase	0.0077	0.0153	0.0282
Echinococcus multilocularis	cpg binding protein	0.0041	0.0064	0.0061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0041	0.0634
Echinococcus multilocularis	RUN	0.0023	0.002	0.0017
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0007	0.0069
Schistosoma mansoni	tar DNA-binding protein	0.0275	0.0644	0.2579
Toxoplasma gondii	CAAX amino terminal protease family protein	0.0018	0.0008	0.0093
Leishmania major	GTP-binding protein, putative	0.0064	0.012	0.1972
Loa Loa (eye worm)	phosphatidylinositol 3	0.0053	0.0095	0.0334
Onchocerca volvulus		0.0077	0.0153	0.1183
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0067
Trypanosoma cruzi	metallo- peptidase, Clan M- Family M48	0.0066	0.0126	0.6832
Schistosoma mansoni	smad	0.0077	0.0152	0.0602
Mycobacterium tuberculosis	Probable reductase	0.0107	0.0226	0.042
Echinococcus granulosus	dna polymerase eta	0.002	0.0011	0.0019
Onchocerca volvulus		0.0117	0.0252	0.1994
Echinococcus multilocularis	musashi	0.0117	0.0252	0.0249
Brugia malayi	nuclear receptor NHR-88	0.005	0.0087	0.0318
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0011	0.0462
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0077	0.0153	0.0547
Schistosoma mansoni	ferritin light chain	0.0017	0.0004	0.0004
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0241	0.0558	1
Brugia malayi	hypothetical protein	0.0023	0.002	0.0072
Schistosoma mansoni	nuclear receptor	0.0024	0.0021	0.0076
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0037	0.0055	0.0099
Brugia malayi	AMP-binding enzyme family protein	0.005	0.0086	0.0315
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0158	0.0353	0.035
Schistosoma mansoni	apoferritin-2	0.0017	0.0004	0.0004
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0257	0.0598	0.1117
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.005	0.0086	0.0318
Echinococcus granulosus	dna polymerase kappa	0.002	0.0011	0.0019
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0011	0.0192
Brugia malayi	hypothetical protein	0.048	0.1151	0.4189
Treponema pallidum	bacterioferrin (TpF1)	0.0017	0.0004	0.0019
Brugia malayi	hypothetical protein	0.0078	0.0156	0.0569
Loa Loa (eye worm)	beta-lactamase	0.0077	0.0153	0.0547
Echinococcus granulosus	RUN	0.0023	0.002	0.004
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0053	0.0095	0.1547
Schistosoma mansoni	zinc finger protein	0.0024	0.0021	0.0076
Trypanosoma brucei	Importin-beta N-terminal domain/HEAT-like repeat, putative	0.0016	0.0003	0.0021
Schistosoma mansoni	steroid hormone receptor ad4bp	0.005	0.0087	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0261	0.0609	0.2208
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0118	0.0256	0.0967
Plasmodium vivax	protease, putative	0.0018	0.0008	0.0099
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0077	0.0152	0.0602
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0138	0.0304	0.0302
Brugia malayi	chromobox protein homolog 3	0.0046	0.0076	0.0275
Brugia malayi	RNA recognition motif domain containing protein	0.0275	0.0644	0.2342
Mycobacterium tuberculosis	Conserved protein	0.0077	0.0153	0.0282
Echinococcus multilocularis	ecdysone induced protein 78C	0.005	0.0087	0.0085
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.005	0.0087	0.0085
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0018	0.0007	0.0071
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0007	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0047	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0124	0.027	0.0972
Plasmodium vivax	multidomain scavenger receptor, putative	0.0023	0.002	0.0307
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0077	0.0153	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0153	0.0547
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0027	0.0029	0.0104
Toxoplasma gondii	aldehyde dehydrogenase	0.0257	0.0598	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0024	0.0021	0.0076
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0064	0.012	0.6489
Trypanosoma brucei	importin beta-1 subunit, putative	0.0086	0.0176	0.9611
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.005	0.0087	0.0318
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.005	0.0087	0.0318
Brugia malayi	RNA, U transporter 1	0.0246	0.057	0.2076
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0031	0.0067
Mycobacterium tuberculosis	Probable imidazole glycerol-phosphate dehydratase HisB	0.217	0.533	1
Echinococcus multilocularis	zinc finger protein	0.0062	0.0115	0.0112
Mycobacterium ulcerans	glutaminase	0.0264	0.0616	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0067
Leishmania major	hypothetical protein, conserved	0.0077	0.0153	0.253
Trichomonas vaginalis	D-aminoacylase, putative	0.0077	0.0153	0.2454
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0067
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0078	0.136
Mycobacterium tuberculosis	Probable esterase LipL	0.0077	0.0153	0.0282
Entamoeba histolytica	acyl-CoA synthetase, putative	0.005	0.0086	0.2014
Echinococcus granulosus	histone lysine methyltransferase setb	0.0082	0.0164	0.0378
Echinococcus granulosus	snurportin 1	0.0923	0.2245	0.5235
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0107	0.0226	0.0854
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0083	0.0168	0.2973
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0064	0.012	0.6489
Echinococcus multilocularis	dna polymerase eta	0.002	0.0011	0.0008
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0008	0.0288
Brugia malayi	nuclear receptor NHR-67	0.0024	0.0021	0.0078
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0024	0.0021	0.0104
Brugia malayi	steroid hormone receptor	0.005	0.0087	0.0318
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0017	0.0228
Giardia lamblia	DINP protein human, muc B family	0.002	0.0011	0.0462
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0923	0.2245	0.8167
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.005	0.0087	0.0308
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0078	0.136
Schistosoma mansoni	tar DNA-binding protein	0.0275	0.0644	0.2579
Mycobacterium ulcerans	esterase/lipase LipP	0.0077	0.0153	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0567	0.1366	0.4966
Echinococcus granulosus	neuropeptide receptor	0.0188	0.0428	0.0994
Toxoplasma gondii	hypothetical protein	0.0018	0.0008	0.0093
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.005	0.0087	0.0645
Mycobacterium ulcerans	lipase LipD	0.0077	0.0153	0.0282
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0021	0.0015	0.0028
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0036	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0153	0.0547
Echinococcus granulosus	fetal alzheimer antigen falz	0.0071	0.0137	0.0315
Schistosoma mansoni	hypothetical protein	0.0063	0.0118	0.0465
Schistosoma mansoni	farnesylated-protein converting enzyme 1 (M48 family)	0.0066	0.0126	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0413	0.1494
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.0462	0.1671
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0017	0.0006	0.0049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0061	0.0949
Loa Loa (eye worm)	MH2 domain-containing protein	0.0034	0.0047	0.0162
Giardia lamblia	Hypothetical protein	0.0089	0.0183	1
Echinococcus granulosus	importin 5	0.0016	0.0003	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0153	0.0547
Schistosoma mansoni	ferritin	0.0017	0.0004	0.0004
Treponema pallidum	hypothetical protein	0.0018	0.0008	0.0099
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0078	0.1269
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0083	0.0168	0.063
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0076	0.1191
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0061	0.0949
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0014	0.019
Trypanosoma brucei	trypanothione reductase	0.0047	0.0078	0.4178
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0014	0.019
Schistosoma mansoni	cpg binding protein	0.0041	0.0064	0.0247
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0068	0.106
Schistosoma mansoni	nuclear hormone receptor	0.0024	0.0021	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0076	0.1191
Trichomonas vaginalis	Clan MA, family M48, Ste24 endopeptidase-like metallopeptidase	0.0066	0.0126	0.2014
Brugia malayi	tailless protein	0.0024	0.0021	0.0078
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0011	0.0016
Schistosoma mansoni	ran	0.0064	0.012	0.0472
Schistosoma mansoni	hypothetical protein	0.0023	0.002	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0097	0.0342
Loa Loa (eye worm)	Smad1	0.0077	0.0152	0.0544
Trichomonas vaginalis	esterase, putative	0.0077	0.0153	0.2454
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0102	0.0362
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0018	0.0007	0.0235
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.0095	0.1501
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0035	0.0049	0.0109
Schistosoma mansoni	retinoic acid receptor RXR	0.005	0.0087	0.0341
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.005	0.0087	0.0341
Brugia malayi	Nuclear hormone receptor-like 1	0.0027	0.0029	0.0104
Trypanosoma brucei	importin beta-1 subunit, putative	0.0086	0.0176	0.9611
Schistosoma mansoni	tar DNA-binding protein	0.0275	0.0644	0.2579
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0061	0.0949
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.007	0.0136	0.2174
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.005	0.0087	0.0308
Echinococcus granulosus	dnaJ subfamily B	0.0474	0.1135	0.2645
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.023	0.0532	0.2129
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0184	0.0418	0.0415
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0241	0.0558	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0008	0.0094
Loa Loa (eye worm)	hypothetical protein	0.018	0.0407	0.1471
Trypanosoma cruzi	ISWI complex protein	0.0047	0.0078	0.417
Mycobacterium tuberculosis	Probable conserved integral membrane protein	0.0018	0.0008	0.001
Onchocerca volvulus		0.0033	0.0045	0.0296
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0045	0.0163
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0008	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.0095	0.1501
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0257	0.0598	0.1117
Brugia malayi	hypothetical protein	0.0027	0.0029	0.0104
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0053	0.0095	0.5092
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0059	0.0109	0.1793
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0034	0.051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0061	0.0949
Schistosoma mansoni	ferritin	0.0017	0.0004	0.0004
Schistosoma mansoni	tar DNA-binding protein	0.0275	0.0644	0.2579
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0064	0.012	0.6489
Brugia malayi	hypothetical protein	0.0024	0.0021	0.0078
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.0308
Schistosoma mansoni	hypothetical protein	0.0098	0.0205	0.0814
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.005	0.0087	0.0198
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0241	0.0558	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Mycobacterium ulcerans	imidazoleglycerol-phosphate dehydratase	0.217	0.533	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0037	0.0055	0.0946
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0053	0.0095	0.2212
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0011	0.0136
Mycobacterium tuberculosis	Probable lipase LipE	0.0077	0.0153	0.0282
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0008	0.0288
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0014	0.019
Echinococcus granulosus	chromobox protein 1	0.0082	0.0164	0.0378
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.0109	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0289	0.1042
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0056	0.0102	0.0233
Brugia malayi	follicle stimulating hormone receptor	0.0485	0.1162	0.423
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.005	0.0087	0.0308
Schistosoma mansoni	smad	0.0034	0.0047	0.018
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0077	0.0153	0.0606
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0184	0.0417	0.0415
Mycobacterium ulcerans	integral membrane protein	0.0018	0.0008	0.001
Brugia malayi	Smad1	0.0077	0.0152	0.0554
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0092	0.019	0.0753
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.005	0.0087	0.0198
Leishmania major	hypothetical protein, conserved	0.0078	0.0156	0.2584
Brugia malayi	CHD4 protein	0.0021	0.0015	0.0053
Trichomonas vaginalis	D-aminoacylase, putative	0.0077	0.0153	0.2454
Toxoplasma gondii	HEAT repeat-containing protein	0.0086	0.0176	0.292
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0055	0.019
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0024	0.0021	0.0044
Schistosoma mansoni	hypothetical protein	0.018	0.0407	0.1626
Mycobacterium tuberculosis	Probable conserved integral membrane protein	0.0018	0.0008	0.001
Leishmania major	hypothetical protein, conserved	0.0016	0.0003	0.0006
Onchocerca volvulus	Bile acid receptor homolog	0.005	0.0087	0.0645
Leishmania major	hypothetical protein, conserved	0.0047	0.0078	0.1267
Toxoplasma gondii	exonuclease III APE	0.0018	0.0008	0.0087
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0077	0.0153	0.0282
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0027	0.0029	0.0026
Brugia malayi	conserved hypotetical protein	0.0024	0.0021	0.0078
Echinococcus multilocularis	survival motor neuron protein 1	0.048	0.1151	0.1149
Loa Loa (eye worm)	hypothetical protein	0.0023	0.002	0.0061
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0068	0.106
Schistosoma mansoni	smad1 5 8 and	0.0077	0.0152	0.0602
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0011	0.014
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0083	0.0168	0.2973
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0007	0.0069
Mycobacterium leprae	Probable imidazole glycerol-phosphate dehydratase HisB	0.107	0.261	1
Brugia malayi	glutathione reductase	0.0047	0.0078	0.0284
Mycobacterium tuberculosis	Probable dehydrogenase	0.0107	0.0226	0.042
Brugia malayi	hypothetical protein	0.0184	0.0417	0.1519
Schistosoma mansoni	thyroid hormone receptor	0.005	0.0087	0.0341
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0064	0.012	0.0117
Plasmodium vivax	ataxin-2 like protein, putative	0.0078	0.0156	0.2767
Toxoplasma gondii	HEAT repeat-containing protein	0.0016	0.0003	0.0006
Echinococcus multilocularis	lamin dm0	0.0117	0.0252	0.0249
Echinococcus multilocularis	importin subunit beta 1	0.0086	0.0176	0.0174
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0024	0.0021	0.0067
Leishmania major	DNA polymerase eta, putative	0.002	0.0011	0.014
Toxoplasma gondii	LsmAD domain-containing protein	0.0078	0.0156	0.2584
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0011	0.0016
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0257	0.0598	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0117	0.0252	0.0917
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0077	0.0153	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0256	0.0595	0.2158
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0007	0.0017
Loa Loa (eye worm)	RNA binding protein	0.0275	0.0644	0.2334
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0117	0.0252	0.0907
Trichomonas vaginalis	hypothetical protein	0.0016	0.0003	0.0006
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.005	0.0089
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0241	0.0558	0.1043
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0241	0.0558	0.9337
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0017	0.0004	0.0002
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0567	0.1366	0.4971
Schistosoma mansoni	hypothetical protein	0.1021	0.2488	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0024	0.0021	0.0019
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.023	0.0532	0.1236
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.005	0.0087	0.0318
Trypanosoma brucei	metallo- peptidase, Clan M- Family M48	0.0066	0.0126	0.6832
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0055	0.0099	0.0351
Brugia malayi	Latrophilin receptor protein 2	0.018	0.0407	0.148
Echinococcus granulosus	tar DNA binding protein	0.0275	0.0644	0.1497
Schistosoma mansoni	neuropeptide receptor	0.0188	0.0428	0.1714
Chlamydia trachomatis	hypothetical protein	0.0018	0.0008	0.0099
Brugia malayi	beta-lactamase	0.0077	0.0153	0.0557
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.005	0.0087	0.0341
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0098	0.0205	0.0746
Plasmodium vivax	importin-beta 2, putative	0.0086	0.0176	0.3128
Trichomonas vaginalis	D-aminoacylase, putative	0.0077	0.0153	0.2454
Trichomonas vaginalis	chromobox protein, putative	0.0082	0.0164	0.2637
Brugia malayi	RNA binding protein	0.0275	0.0644	0.2342
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0055	0.019
Brugia malayi	Nuclear hormone receptor E75	0.0024	0.0021	0.0078
Brugia malayi	N-terminal motif family protein	0.0182	0.0413	0.1504
Onchocerca volvulus		0.0077	0.0153	0.1183
Schistosoma mansoni	peptidase Clp (S14 family)	0.0241	0.0558	0.2235
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0492	0.118	0.221
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0241	0.0558	0.0556
Entamoeba histolytica	CAAX amino terminal protease family	0.0018	0.0008	0.0124
Loa Loa (eye worm)	MH1 domain-containing protein	0.0077	0.0152	0.0544
Echinococcus multilocularis	geminin	0.1021	0.2488	0.2486
Echinococcus granulosus	caax prenyl protease 1	0.0066	0.0126	0.0288
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0241	0.0558	0.2022
Trichomonas vaginalis	ferritin, putative	0.0017	0.0004	0.0017
Schistosoma mansoni	ran	0.0064	0.012	0.0472
Mycobacterium tuberculosis	Conserved protein	0.0077	0.0153	0.0282
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Trypanosoma brucei	hypothetical protein, conserved	0.0077	0.0153	0.8325
Entamoeba histolytica	hypothetical protein	0.0184	0.0417	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.005	0.0087	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0229	0.0823
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0241	0.0558	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0118	0.0256	0.0475
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0024	0.0021	0.0078
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Brugia malayi	TAR-binding protein	0.0275	0.0644	0.2342
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0241	0.0558	0.9337
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Brugia malayi	MH2 domain containing protein	0.0077	0.0152	0.0554
Brugia malayi	cytoplasmic intermediate filament protein	0.0063	0.0118	0.0428
Schistosoma mansoni	family U48 unassigned peptidase (U48 family)	0.0089	0.0183	0.0727
Entamoeba histolytica	hypothetical protein	0.0184	0.0417	1
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0082	0.0164	0.0162
Brugia malayi	nuclear receptor RXR	0.0024	0.0021	0.0078
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0082	0.0164	0.0651
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0107	0.0226	0.042
Trichomonas vaginalis	penicillin-binding protein, putative	0.0077	0.0153	0.2454
Schistosoma mansoni	intermediate filament proteins	0.0117	0.0252	0.1003
Onchocerca volvulus		0.0098	0.0205	0.1609
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0061	0.0949
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0014	0.019
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0022	0.0017	0.082
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0247	0.0888
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0011	0.0016
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0241	0.0558	0.2127
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0077	0.0153	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0029	0.0093
Schistosoma mansoni	bromodomain containing protein	0.0195	0.0445	0.1779
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0034	0.0047	0.0045
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.0068	0.3603
Schistosoma mansoni	smad1 5 8 and	0.0077	0.0152	0.0602
Brugia malayi	hypothetical protein	0.0027	0.0029	0.0104
Onchocerca volvulus		0.0023	0.002	0.0089
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0011	0.0016
Loa Loa (eye worm)	latrophilin receptor protein 2	0.018	0.0407	0.1471
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0008	0.001
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0024	0.0021	0.0044
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0184	0.0417	0.0969
Mycobacterium tuberculosis	Probable lipase LipD	0.0077	0.0153	0.0282
Schistosoma mansoni	smad1 5 8 and	0.0077	0.0152	0.0602
Brugia malayi	MH2 domain containing protein	0.1126	0.2748	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0241	0.0558	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.005	0.0087	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0067
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0078	0.0274
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.005	0.0087	0.0308
Echinococcus granulosus	expressed protein	0.0017	0.0004	0.0002
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0024	0.0021	0.0076
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0053	0.0095	0.5092
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0082	0.0164	0.0651
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0011	0.0462
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.005	0.0087	0.0318
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0034	0.0047	0.0045
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0059	0.0109	0.0398
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0008	0.0094
Trichomonas vaginalis	chromobox protein, putative	0.0049	0.0084	0.1331
Echinococcus multilocularis	snurportin 1	0.0923	0.2245	0.2243
Schistosoma mansoni	nuclear receptor	0.0024	0.0021	0.0076
Echinococcus granulosus	peptidase Clp S14 family	0.0158	0.0353	0.0818
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0078	0.136
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0008	0.0085
Brugia malayi	kap beta 3 protein	0.0016	0.0003	0.0011
Brugia malayi	nuclear hormone receptor family member odr-7	0.0024	0.0021	0.0078
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0021	0.0014	0.019
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0068	0.106
Schistosoma mansoni	aldehyde dehydrogenase	0.0257	0.0598	0.2394
Schistosoma mansoni	lipoxygenase	0.0138	0.0304	0.1213
Loa Loa (eye worm)	hypothetical protein	0.0261	0.0609	0.2208
Schistosoma mansoni	ferritin light chain	0.0017	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0055	0.019
Brugia malayi	Bromodomain containing protein	0.0117	0.0251	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0076	0.0265
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.005	0.0086	0.0157
Brugia malayi	nuclear hormone receptor	0.0024	0.0021	0.0078
Mycobacterium ulcerans	acyl-CoA synthetase	0.005	0.0086	0.0157
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0063	0.0118	0.0418
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0018	0.0007	0.0071
Loa Loa (eye worm)	intermediate filament protein	0.0117	0.0252	0.0907
Loa Loa (eye worm)	bromodomain containing protein	0.0054	0.0096	0.0338
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0078	0.0142
Brugia malayi	Thioredoxin reductase	0.0047	0.0078	0.0284
Brugia malayi	intermediate filament protein	0.0117	0.0252	0.0917
Echinococcus multilocularis	ferritin	0.0017	0.0004	0.0001
Plasmodium falciparum	glutathione reductase	0.0047	0.0078	0.136
Onchocerca volvulus		0.0077	0.0153	0.1183
Brugia malayi	nuclear hormone receptor	0.005	0.0087	0.0318
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.005	0.0087	0.0308
Echinococcus multilocularis	tumor protein p63	0.1748	0.4285	0.4284
Toxoplasma gondii	hypothetical protein	0.0083	0.0168	0.2775
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0006	0.0049
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0008	0.001
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0055	0.019
Loa Loa (eye worm)	transcription factor SMAD2	0.1126	0.2748	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.018	0.0407	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0023	0.002	0.0061
Brugia malayi	nuclear receptor RXR	0.0027	0.0029	0.0104
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.005	0.0086	0.0318
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0011	0.0029
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0041	0.0621
Entamoeba histolytica	Ran family GTPase	0.0064	0.012	0.2821
Schistosoma mansoni	transcription factor LCR-F1	0.0184	0.0417	0.1669
Trypanosoma cruzi	importin beta-1 subunit, putative	0.007	0.0136	0.7375
Brugia malayi	hypothetical protein	0.0261	0.0609	0.2217
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.005	0.0087	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0067
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0017	0.0004	0.0019
Onchocerca volvulus		0.005	0.0086	0.0637
Loa Loa (eye worm)	CHromoDomain protein family member	0.0021	0.0015	0.0043
Brugia malayi	Steroid receptor seven-up type 2	0.005	0.0087	0.0318
Schistosoma mansoni	hypothetical protein	0.0388	0.0922	0.3699
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0024	0.0021	0.0104
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0485	0.1162	0.4224
Brugia malayi	Phospholipase A2 family protein	0.0108	0.0229	0.0833
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0035	0.005	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0021	0.0067
Onchocerca volvulus	Phospholipase A2 homolog	0.0512	0.1228	1
Schistosoma mansoni	hypothetical protein	0.0184	0.0417	0.1669
Echinococcus granulosus	beta LACTamase domain containing family member	0.0077	0.0153	0.0351
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0257	0.0598	0.0595
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.005	0.0087	0.0085
Mycobacterium leprae	Probable lipase LipE	0.0077	0.0153	0.0573
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.023	0.0532	0.1926
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0064	0.012	0.6489
Onchocerca volvulus	Huntingtin homolog	0.0261	0.0609	0.4923
Leishmania major	4-coumarate:coa ligase-like protein	0.005	0.0086	0.1409
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0056	0.0102	0.01
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0048	0.0745
Toxoplasma gondii	HEAT repeat-containing protein	0.0016	0.0003	0.0006
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0077	0.0153	0.0557
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.005	0.0087	0.0341
Schistosoma mansoni	hypothetical protein	0.0047	0.0078	0.0303
Entamoeba histolytica	CAAX prenyl protease, putative	0.0066	0.0126	0.297
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0036	0.0556
Trichomonas vaginalis	ran, putative	0.0064	0.012	0.1913
Schistosoma mansoni	hypothetical protein	0.0923	0.2245	0.9022
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0024	0.0021	0.0019
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0043	0.0069	0.0266
Echinococcus granulosus	importin subunit beta 1	0.0086	0.0176	0.0406
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0078	0.0274
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0011	0.0034
Onchocerca volvulus	Protein ultraspiracle homolog	0.005	0.0087	0.0645
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0008	0.0085
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0021	0.0015	0.0049
Onchocerca volvulus		0.0024	0.0021	0.0104
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.005	0.0087	0.0318
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0052	0.0091	0.0357
Schistosoma mansoni	apoferritin-2	0.0017	0.0004	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0075	0.1186
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0118	0.0256	0.0475
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0034	0.0508
Brugia malayi	Nuclear hormone receptor-like 1	0.0027	0.0029	0.0104
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0017	0.0004	0.0026
Loa Loa (eye worm)	MH2 domain-containing protein	0.0077	0.0152	0.0544
Brugia malayi	beta-lactamase family protein	0.0077	0.0153	0.0557
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0027	0.0029	0.0104
Loa Loa (eye worm)	hypothetical protein	0.048	0.1151	0.4183
Schistosoma mansoni	rab6-interacting	0.0023	0.002	0.0069
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0007	0.0004
Schistosoma mansoni	cellular tumor antigen P53	0.0256	0.0595	0.2385
Loa Loa (eye worm)	hypothetical protein	0.005	0.0087	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0055	0.019
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.005	0.0087	0.0198
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.002	0.0017
Leishmania major	DNA polymerase kappa, putative	0.002	0.0011	0.014
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0029	0.0093
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0059	0.0109	0.0429
Loa Loa (eye worm)	hypothetical protein	0.002	0.0011	0.0029
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0011	0.0462
Schistosoma mansoni	glutaminase	0.0264	0.0616	0.2467
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0011	0.004
Schistosoma mansoni	hypothetical protein	0.0474	0.1135	0.4558
Onchocerca volvulus		0.0036	0.0051	0.0348
Mycobacterium ulcerans	hypothetical protein	0.0077	0.0153	0.0282
Schistosoma mansoni	lamin	0.0117	0.0252	0.1003
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.0109	0.02
Onchocerca volvulus		0.0086	0.0175	0.1362
Brugia malayi	Probable ClpP-like protease	0.0241	0.0558	0.2031
Schistosoma mansoni	thyroid hormone receptor	0.005	0.0087	0.0341
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.005	0.0087	0.0198
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0008	0.0028
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0008	0.0018
Loa Loa (eye worm)	heterochromatin protein 1	0.0082	0.0164	0.0588
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0041	0.0634
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.002	0.004
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0138	0.0304	0.0704
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.007	0.0136	0.2174
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.005	0.0087	0.0318
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0183	0.0657

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1208837

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1169420