Detailed information for compound 139647

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 468.552 | Formula: C21H20N6O3S2
  • H donors: 3 H acceptors: 5 LogP: 1.6 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(CC[C@@H]1NS(=O)(=O)c1sc2c(c1)nccc2)Cc1cc2c(cc1N)ccnc2N
  • InChi: 1S/C21H20N6O3S2/c22-15-9-12-3-6-25-20(23)14(12)8-13(15)11-27-7-4-16(21(27)28)26-32(29,30)19-10-17-18(31-19)2-1-5-24-17/h1-3,5-6,8-10,16,26H,4,7,11,22H2,(H2,23,25)/t16-/m0/s1
  • InChiKey: UORSJJNIHCUTDL-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Coagulation factor X Starlite/ChEMBL References
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0017 0.0059 0.0048
Trichomonas vaginalis set domain proteins, putative 0.017 0.0919 1
Trichomonas vaginalis glutaminase, putative 0.0163 0.0881 0.9582
Echinococcus granulosus thioredoxin glutathione reductase 0.0062 0.0313 0.1714
Loa Loa (eye worm) glutathione reductase 0.0062 0.031 0.3501
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.001 0.0019 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0031 0.002
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0067 0.0341 0.0459
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0038 0.018 0.5628
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.001 0.0019 0.0008
Echinococcus multilocularis neurogenic locus notch protein 0.0012 0.0033 0.0045
Loa Loa (eye worm) glutamate receptor 0.0043 0.0207 0.2335
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0172 0.1791
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0014 0.0045 0.0061
Echinococcus granulosus epidermal growth factor receptor 0.003 0.0135 0.0741
Schistosoma mansoni apoferritin-2 0.0008 0.0012 0.0109
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0162 0.1685
Schistosoma mansoni tyrosine kinase 0.003 0.0132 0.1236
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0162 0.4065
Loa Loa (eye worm) hypothetical protein 0.0135 0.0726 0.8232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0201 0.1882
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0019 0.007 0.0095
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0305 0.0412
Echinococcus granulosus metabotropic glutamate receptor 5 0.0135 0.0726 0.3975
Echinococcus multilocularis zinc finger protein 0.0021 0.008 0.0107
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0162 0.0151
Brugia malayi Bromodomain containing protein 0.0038 0.0179 0.2017
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0017 0.0057 0.1435
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0084 0.2141
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0172 0.4469
Loa Loa (eye worm) notch protein 0.0012 0.0033 0.0353
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0236 0.221
Echinococcus granulosus snurportin 1 0.0125 0.0664 0.3639
Loa Loa (eye worm) hypothetical protein 0.0071 0.0362 0.4092
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0002 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0106 0.2532
Schistosoma mansoni tar DNA-binding protein 0.0038 0.0176 0.1649
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0162 0.0151
Schistosoma mansoni ferritin 0.0008 0.0012 0.0109
Mycobacterium ulcerans hypothetical protein 0.0035 0.0162 0.0151
Leishmania major cytochrome p450-like protein 0.001 0.0019 0.024
Trypanosoma cruzi polynucleotide kinase 3'-phosphatase, putative 0.0074 0.0381 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0009 0.0017 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0201 0.0271
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.001 0.0019 0.0008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0017 0.006 0.0662
Schistosoma mansoni steroid hormone receptor ad4bp 0.0007 0.0002 0.002
Schistosoma mansoni notch 0.0012 0.0033 0.031
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0162 0.1823
Mycobacterium ulcerans lipase LipD 0.0035 0.0162 0.0151
Loa Loa (eye worm) hypothetical protein 0.0032 0.0145 0.163
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.001 0.0019 0.0008
Brugia malayi Protein kinase domain containing protein 0.0037 0.0172 0.1937
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0014 0.0045 0.0061
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0007 0.0002 0.0003
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0162 0.0151
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0009 0.0012 0.0252
Onchocerca volvulus 0.017 0.0919 1
Echinococcus granulosus protein jagged 1 0.0012 0.0033 0.0182
Echinococcus granulosus nmda type glutamate receptor 0.001 0.0022 0.0121
Echinococcus granulosus laminin 0.0032 0.0145 0.0796
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0094 0.1048
Echinococcus granulosus expressed protein 0.0008 0.0012 0.0064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0149 0.0803 0.9117
Onchocerca volvulus 0.0011 0.0025 0.0252
Echinococcus granulosus receptor type guanylyl cyclase 0.0011 0.0025 0.0138
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0037 0.0392
Trypanosoma brucei importin beta-1 subunit, putative 0.0012 0.003 0.0552
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.1785 1 1
Schistosoma mansoni ran 0.0009 0.0012 0.0115
Loa Loa (eye worm) hypothetical protein 0.0018 0.0064 0.0709
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0172 0.1607
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.063
Echinococcus multilocularis 0.001 0.0019 0.0026
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0009 0.0073
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0067 0.0341 0.1866
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0468
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0084 0.2141
Brugia malayi Metabotropic glutamate receptor precursor. 0.011 0.0583 0.6606
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0031 0.002
Schistosoma mansoni cell polarity protein 0.0012 0.0033 0.031
Loa Loa (eye worm) hypothetical protein 0.0031 0.014 0.157
Schistosoma mansoni apoferritin-2 0.0008 0.0012 0.0109
Brugia malayi metabotropic glutamate receptor type 2 0.0054 0.0266 0.2997
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0162 0.1685
Schistosoma mansoni hypothetical protein 0.0014 0.0045 0.0425
Echinococcus multilocularis muscleblind protein 0.0149 0.0804 0.1084
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0031 0.002
Schistosoma mansoni cpg binding protein 0.002 0.0077 0.0716
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.001 0.0019 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0162 0.1823
Schistosoma mansoni kinase 0.002 0.0074 0.0692
Schistosoma mansoni tar DNA-binding protein 0.0038 0.0176 0.1649
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0096 0.09
Echinococcus granulosus serine protein kinase ATM 0.0008 0.0009 0.005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0204 0.2298
Loa Loa (eye worm) thioredoxin reductase 0.0062 0.031 0.3501
Schistosoma mansoni metabotropic glutamate receptor 0.0054 0.0266 0.2482
Brugia malayi glutathione reductase 0.0062 0.031 0.3501
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0008 0.0009 0.0079
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0021 0.0084 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0125 0.0664 0.7535
Echinococcus granulosus protein jagged 1 0.0012 0.0033 0.0182
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.014 0.0753 0.0742
Brugia malayi mbt repeat family protein 0.0017 0.0057 0.063
Schistosoma mansoni hypothetical protein 0.0014 0.0045 0.0425
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0162 0.1685
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0494
Loa Loa (eye worm) cytochrome P450 0.001 0.0019 0.0197
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0021 0.0084 0.1938
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Loa Loa (eye worm) MBCTL1 0.0019 0.007 0.0777
Schistosoma mansoni hypothetical protein 0.0018 0.0064 0.0602
Echinococcus multilocularis bifunctional polynucleotide 0.0074 0.0381 0.0514
Schistosoma mansoni notch 0.0012 0.0033 0.031
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0007 0.0002 0.0012
Echinococcus granulosus neurogenic locus notch protein 4 0.0012 0.0033 0.0182
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0008 0.0009 0.0084
Giardia lamblia High cysteine protein 0.0012 0.0033 0.1249
Schistosoma mansoni slit 0.0012 0.0033 0.031
Schistosoma mansoni laminin gamma-3 chain 0.0012 0.0033 0.031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0228
Echinococcus multilocularis protein jagged 2 0.0012 0.0033 0.0045
Trypanosoma cruzi extracellular receptor, putative 0.001 0.0022 0.0513
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.001 0.0019 0.0008
Brugia malayi GCC2 and GCC3 family protein 0.0012 0.0033 0.0353
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0007 0.0002 0.002
Echinococcus multilocularis epidermal growth factor receptor 0.003 0.0135 0.0182
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0012 0.0033 0.0339
Mycobacterium tuberculosis Conserved protein 0.0035 0.0162 0.0151
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0166 0.0224
Brugia malayi EGF-like domain containing protein 0.0012 0.0033 0.0353
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0019 0.007 0.0386
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0007 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Echinococcus granulosus cpg binding protein 0.002 0.0077 0.0419
Trichomonas vaginalis CAMK family protein kinase 0.0019 0.0071 0.0683
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.001 0.0019 0.0008
Schistosoma mansoni hypothetical protein 0.0031 0.014 0.1309
Onchocerca volvulus Arrow homolog 0.0032 0.0145 0.1562
Plasmodium falciparum glutathione reductase 0.0021 0.0084 0.1938
Brugia malayi Cell death protein 3 precursor 0.0021 0.0084 0.093
Echinococcus granulosus GTP binding nuclear protein Ran 0.0009 0.0012 0.0067
Leishmania major cytochrome p450-like protein 0.001 0.0019 0.024
Schistosoma mansoni hypothetical protein 0.0015 0.0048 0.0447
Toxoplasma gondii calcium binding egf domain-containing protein 0.0032 0.0145 0.4532
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0305 0.0294
Loa Loa (eye worm) glutaminase 2 0.0163 0.0881 1
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0002 0.002
Loa Loa (eye worm) glutamate receptor 0.011 0.0583 0.6606
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0034 0.0155 0.0143
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.001 0.0019 0.0008
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0017 0.0059 0.0048
Mycobacterium ulcerans glutaminase 0.0163 0.0881 0.087
Leishmania major cytochrome p450-like protein 0.0013 0.0037 0.0818
Entamoeba histolytica hypothetical protein 0.0009 0.0017 0.0219
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0305 0.9856
Echinococcus granulosus protein jagged 2 0.0012 0.0033 0.0182
Loa Loa (eye worm) hypothetical protein 0.0043 0.0204 0.2298
Toxoplasma gondii NADPH-glutathione reductase 0.0021 0.0084 0.2487
Plasmodium falciparum thioredoxin reductase 0.0021 0.0084 0.1938
Echinococcus multilocularis atrial natriuretic peptide receptor 0.001 0.0022 0.003
Trichomonas vaginalis glutathione reductase, putative 0.0021 0.0084 0.0822
Loa Loa (eye worm) TK/EGFR protein kinase 0.003 0.0135 0.1516
Schistosoma mansoni importin beta-1 0.0012 0.003 0.0277
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0032 0.0145 0.163
Mycobacterium ulcerans lipoprotein LpqF 0.0034 0.0155 0.0143
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1326 0.7418 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0084 0.2008
Schistosoma mansoni protein kinase 0.0011 0.0025 0.0236
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0092 0.0482 0.065
Schistosoma mansoni hypothetical protein 0.0014 0.0045 0.0425
Trichomonas vaginalis CMGC family protein kinase 0.0017 0.0057 0.0528
Schistosoma mansoni tyrosine kinase 0.0067 0.0341 0.3184
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0019 0.0441
Echinococcus multilocularis glutamate receptor 2 0.001 0.0022 0.003
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.006 0.056
Echinococcus multilocularis isocitrate dehydrogenase 0.0009 0.0017 0.0023
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0007 0.0002 0.002
Brugia malayi glutaminase DH11.1 0.0163 0.0881 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0162 0.1517
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0172 0.1791
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0162 0.0151
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0021 0.0084 0.2008
Brugia malayi EGF-like domain containing protein 0.0012 0.0033 0.0353
Brugia malayi Receptor family ligand binding region containing protein 0.0028 0.0123 0.1371
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.001 0.0019 0.0008
Echinococcus granulosus SAM and MBT domain containing protein 0.0017 0.0057 0.0315
Echinococcus granulosus notch 0.0012 0.0033 0.0182
Brugia malayi Pre-SET motif family protein 0.0149 0.0803 0.9117
Loa Loa (eye worm) hypothetical protein 0.0032 0.0145 0.163
Trypanosoma cruzi trypanothione reductase, putative 0.0021 0.0084 0.2141
Trichomonas vaginalis ran, putative 0.0009 0.0012 0.0036
Leishmania major importin beta-1 subunit, putative 0.0009 0.0017 0.0165
Schistosoma mansoni metabotropic glutamate receptor 0.0092 0.0482 0.4507
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0009 0.0017 0.0377
Brugia malayi isocitrate dehydrogenase 0.0009 0.0017 0.0169
Echinococcus multilocularis receptor type guanylyl cyclase 0.0011 0.0025 0.0034
Echinococcus multilocularis neurogenic locus protein delta 0.0012 0.0033 0.0045
Schistosoma mansoni sex comb on midleg homolog 0.0017 0.0057 0.0537
Trypanosoma cruzi ISWI complex protein 0.0015 0.005 0.1249
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.001 0.0019 0.0008
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0172 0.4376
Schistosoma mansoni basic helix-loop-helix transcription factor hes-related 0.0014 0.0045 0.0421
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0021 0.0084 0.0072
Echinococcus multilocularis FTZ F1 alpha 0.0007 0.0002 0.0003
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0162 0.0151
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.001 0.0019 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0038 0.0176 0.1649
Schistosoma mansoni hypothetical protein 0.0012 0.0033 0.031
Plasmodium vivax thioredoxin reductase, putative 0.0062 0.031 0.8059
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0017 0.0057 0.1435
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0059 0.0651
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0162 0.0151
Schistosoma mansoni zinc finger protein 0.0021 0.008 0.0744
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.018 0.1876
Echinococcus multilocularis nmda type glutamate receptor 0.001 0.0022 0.003
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.001 0.0019 0.0008
Schistosoma mansoni ferritin light chain 0.0008 0.0012 0.0109
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0377
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0009 0.0017 0.0213
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0162 0.4215
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0037 0.0894
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.001 0.0022 0.0121
Loa Loa (eye worm) glutaminase 0.0163 0.0881 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0804 0.9126
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0071 0.0362 0.0351
Brugia malayi cytochrome P450 0.001 0.0019 0.0197
Echinococcus multilocularis epidermal growth factor receptor 0.003 0.0135 0.0182
Echinococcus granulosus neural cadherin 0.0012 0.0033 0.0182
Schistosoma mansoni tyrosine kinase 0.003 0.0135 0.1265
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0651
Brugia malayi Cytochrome P450 family protein 0.0013 0.0037 0.0392
Brugia malayi Delta serrate ligand family protein 0.0012 0.0033 0.0353
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.018 0.1876
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0028 0.0151
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0037 0.0392
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0084 0.2141
Onchocerca volvulus Bifunctional polynucleotide phosphatase\/kinase homolog 0.0074 0.0381 0.4137
Schistosoma mansoni cpg binding protein 0.002 0.0077 0.0716
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0028 0.0123 0.1371
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0305 0.0411
Mycobacterium tuberculosis Probable oxidoreductase 0.0156 0.0841 0.083
Echinococcus granulosus epidermal growth factor receptor 0.003 0.0135 0.0741
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0305 0.2855
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0017 0.0057 0.0537
Trypanosoma brucei polynucleotide kinase 3'-phosphatase, putative 0.0074 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.018 0.2022
Echinococcus granulosus muscleblind protein 0.0149 0.0804 0.4405
Onchocerca volvulus 0.001 0.0022 0.0219
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Onchocerca volvulus 0.0012 0.0033 0.0339
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0021 0.0084 0.2141
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.093
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0106 0.2532
Brugia malayi Calcium binding EGF domain containing protein 0.0012 0.0033 0.0353
Trypanosoma brucei protein kinase, putative 0.0017 0.0057 0.129
Echinococcus multilocularis ferritin 0.0008 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Trypanosoma cruzi cytochrome p450-like protein, putative 0.001 0.0019 0.0441
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0201 0.0271
Echinococcus granulosus neurogenic locus notch protein 0.0012 0.0033 0.0182
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1231 0.1221
Schistosoma mansoni retinoic acid receptor RXR 0.0007 0.0002 0.002
Echinococcus granulosus apoptotic protease activating factor 1 0.0015 0.0048 0.0262
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0162 0.0151
Echinococcus multilocularis tumor protein p63 0.0331 0.1825 0.2461
Onchocerca volvulus 0.0017 0.0057 0.0604
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.001 0.0019 0.0008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0014 0.0045 0.0249
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.001 0.0019 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0059 0.1583
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.014 0.0753 0.0742
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.001 0.0019 0.0279
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0017 0.0057 0.0625
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0046 0.0222 0.2497
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0021 0.0084 0.0783
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0084 0.2141
Schistosoma mansoni polynucleotide kinase-3'-phosphatase 0.0074 0.0381 0.3565
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Schistosoma mansoni hypothetical protein 0.0012 0.0033 0.031
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0009 0.0017 0.0023
Echinococcus multilocularis mitogen activated protein kinase 3 0.0017 0.0057 0.0077
Schistosoma mansoni hypothetical protein 0.0012 0.0033 0.031
Echinococcus multilocularis mitogen activated protein kinase 0.0017 0.0057 0.0077
Schistosoma mansoni septate junction protein 0.0012 0.0033 0.031
Brugia malayi RNA binding protein 0.0038 0.0176 0.1984
Schistosoma mansoni tar DNA-binding protein 0.0038 0.0176 0.1649
Plasmodium falciparum bifunctional polynucleotide phosphatase/kinase 0.0074 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0381 0.4316
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0037 0.0392
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0022 0.0086 0.2565
Schistosoma mansoni tar DNA-binding protein 0.0038 0.0176 0.1649
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0013 0.0035 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0777
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0038 0.018 0.0242
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Trichomonas vaginalis CMGC family protein kinase 0.0017 0.0057 0.0528
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.001 0.0019 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0002 0.0012
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0021 0.0084 0.093
Onchocerca volvulus 0.0017 0.0059 0.0624
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0021 0.0084 0.1938
Brugia malayi EGF-like domain containing protein 0.0012 0.0033 0.0353
Leishmania major hypothetical protein, conserved 0.0035 0.0162 0.5044
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.001 0.0019 0.0008
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0009 0.0012 0.0115
Trichomonas vaginalis CMGC family protein kinase 0.0017 0.0057 0.0528
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.001 0.0019 0.0008
Schistosoma mansoni zinc finger protein 0.0015 0.005 0.0468
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Echinococcus multilocularis Tolloid protein 1 0.0032 0.0145 0.0196
Echinococcus multilocularis insulin receptor 0.0067 0.0341 0.0459
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0017 0.0057 0.1506
Echinococcus granulosus tumor protein p63 0.0331 0.1825 1
Echinococcus granulosus neurogenic locus notch protein 0.0012 0.0033 0.0182
Toxoplasma gondii cytochrome p450 superfamily protein 0.001 0.0019 0.0345
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0007 0.0002 0.002
Brugia malayi Importin beta-1 subunit 0.0012 0.003 0.0313
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0009 0.0017 0.0093
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.001 0.0022 0.003
Schistosoma mansoni glutaminase 0.0163 0.0881 0.8233
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0011 0.0025 0.0252
Echinococcus granulosus histone lysine methyltransferase setb 0.0039 0.0182 0.0998
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0007 0.0002 0.002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0377
Brugia malayi PHD-finger family protein 0.0026 0.011 0.1223
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0172 0.1791
Loa Loa (eye worm) hypothetical protein 0.0037 0.0172 0.1933
Mycobacterium leprae putative cytochrome p450 0.001 0.0019 0.0016
Echinococcus multilocularis neurogenic locus protein delta 0.0012 0.0033 0.0045
Brugia malayi TAR-binding protein 0.0038 0.0176 0.1984
Loa Loa (eye worm) hypothetical protein 0.0035 0.0162 0.1823
Echinococcus multilocularis tyrosine kinase 0.0011 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0035 0.0162 0.1823
Echinococcus granulosus ferritin 0.0008 0.0012 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0201 0.1882
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0096 0.013
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.001 0.0019 0.0008
Trichomonas vaginalis importin beta-1, putative 0.0009 0.0017 0.009
Brugia malayi Receptor family ligand binding region containing protein 0.0011 0.0025 0.0263
Onchocerca volvulus 0.0048 0.0236 0.2556
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0022 0.0086 0.0116
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0019 0.0106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Brugia malayi Cadherin domain containing protein 0.0012 0.0033 0.0353
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0305 0.2855
Schistosoma mansoni notch 0.0012 0.0033 0.031
Echinococcus multilocularis laminin 0.0032 0.0145 0.0196
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.001 0.0019 0.0008
Onchocerca volvulus Serine\/threonine kinase homolog 0.0038 0.018 0.1937
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0009 0.0012 0.0115
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0066 0.0332 0.1821
Echinococcus granulosus insulin receptor 0.0067 0.0341 0.1866
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0009 0.0012 0.0252
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0021 0.0084 0.2405
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0021 0.0084 0.0113
Echinococcus granulosus geminin 0.017 0.0918 0.5028
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0032 0.0145 0.163
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0066 0.0332 0.0448
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0804 0.1084
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0106 0.2597
Brugia malayi Protein kinase domain containing protein 0.0067 0.0341 0.3852
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.0173 0.1614
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0021 0.0084 0.2008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0022 0.0086 0.0805
Loa Loa (eye worm) hypothetical protein 0.0044 0.0209 0.2358
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0009 0.0017 0.0128
Toxoplasma gondii isocitrate dehydrogenase 0.0009 0.0017 0.0264
Schistosoma mansoni bromodomain containing protein 0.0064 0.0325 0.3041
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0125 0.0667 0.6238
Echinococcus multilocularis tar DNA binding protein 0.0038 0.0176 0.0238
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0017 0.0057 0.1506
Schistosoma mansoni cytochrome P450 0.001 0.0019 0.0182
Toxoplasma gondii thioredoxin reductase 0.0062 0.031 1
Echinococcus granulosus tar DNA binding protein 0.0038 0.0176 0.0967
Brugia malayi hypothetical protein 0.0025 0.0106 0.1179
Brugia malayi Calcitonin receptor-like protein seb-1 0.0046 0.0222 0.2497
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0034 0.0155 0.0292
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0009 0.0017 0.0023
Echinococcus multilocularis importin subunit beta 1 0.0012 0.003 0.004
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0017 0.0057 0.129
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0377
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0172 0.0232
Plasmodium vivax glutathione reductase, putative 0.0062 0.031 0.8059
Brugia malayi serine/threonine-protein kinase plk-2 0.0038 0.018 0.2021
Echinococcus multilocularis serine protein kinase ATM 0.0008 0.0009 0.0012
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0009 0.0012 0.0017
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.001 0.0019 0.0008
Echinococcus granulosus histone acetyltransferase MYST2 0.0019 0.007 0.0386
Schistosoma mansoni glutamate receptor NMDA 0.001 0.0022 0.0207
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.001 0.0022 0.0121
Onchocerca volvulus Poor gastrulation protein homolog 0.0018 0.0064 0.0679
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0172 0.4469
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.1903
Trichomonas vaginalis mercuric reductase, putative 0.0021 0.0084 0.0822
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.001 0.0019 0.0008
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0012 0.0033 0.0353
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0021 0.0084 0.2008
Schistosoma mansoni caspase-7 (C14 family) 0.0021 0.0084 0.0784
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0037 0.074
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0156 0.0841 0.1691
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0007 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0651
Entamoeba histolytica acyl-coA synthetase, putative 0.0017 0.0059 0.1351
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Loa Loa (eye worm) RNA binding protein 0.0038 0.0176 0.1984
Echinococcus multilocularis protein jagged 1 0.0012 0.0033 0.0045
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0007 0.0002 0.002
Entamoeba histolytica hypothetical protein 0.001 0.0022 0.0352
Echinococcus multilocularis apoptotic protease activating factor 1 0.0015 0.0048 0.0064
Brugia malayi beta-lactamase family protein 0.0035 0.0162 0.1823
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0014 0.0045 0.0249
Brugia malayi hypothetical protein 0.0016 0.0056 0.0608
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0009 0.0017 0.0023
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0009 0.0012 0.0108
Entamoeba histolytica acyl-CoA synthetase, putative 0.0017 0.0059 0.1351
Onchocerca volvulus Putative cubilin 0.0012 0.0033 0.0339
Plasmodium vivax bifunctional polynucleotide phosphatase/kinase, putative 0.0074 0.0381 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0052 0.0568
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0182 0.1702
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0162 0.0307
Plasmodium falciparum thioredoxin reductase 0.0062 0.031 0.8059
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0009 0.0017 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0162 0.1517
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.001 0.0019 0.0008
Toxoplasma gondii HEAT repeat-containing protein 0.0012 0.003 0.0683
Brugia malayi beta-lactamase family protein 0.0035 0.0162 0.1823
Trichomonas vaginalis esterase, putative 0.0035 0.0162 0.1685
Echinococcus multilocularis caspase 2 0.0021 0.0084 0.0113
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0172 0.4376
Echinococcus multilocularis polycomb protein SCMH1 0.0017 0.0057 0.0077
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0156 0.0841 0.083
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.052
Trypanosoma cruzi polo-like protein kinase, putative 0.0038 0.018 0.4674
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0002 0.002
Schistosoma mansoni hypothetical protein 0.0021 0.008 0.0748
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0377
Plasmodium falciparum importin beta, putative 0.0012 0.003 0.0469
Loa Loa (eye worm) latrophilin receptor protein 2 0.0014 0.0045 0.0494
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0084 0.2405
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0172 0.0942
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0022 0.0086 0.0805
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0025 0.0263
Brugia malayi Guanylyl cyclase protein 23 0.0011 0.0025 0.0263
Schistosoma mansoni tyrosine kinase 0.003 0.0135 0.1265
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0305 0.1674
Echinococcus multilocularis expressed protein 0.0008 0.0012 0.0016
Treponema pallidum NADH oxidase 0.0021 0.0084 1
Echinococcus granulosus delta-like protein 1 0.0012 0.0033 0.0182
Trypanosoma brucei trypanothione reductase 0.0062 0.031 0.8076
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.001 0.0019 0.0008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0007 0.0002 0.0003
Echinococcus multilocularis snurportin 1 0.0125 0.0664 0.0895
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.001 0.0019 0.0008
Echinococcus multilocularis glutamate receptor 2 0.001 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.0032 0.0145 0.163
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0059 0.1583
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0028 0.0123 0.1371
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0201 0.1882
Brugia malayi Cytochrome P450 family protein 0.0013 0.0037 0.0392
Giardia lamblia Kinase, PLK 0.0038 0.018 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0162 0.1685
Brugia malayi EGF-like domain containing protein 0.0012 0.0033 0.0353
Schistosoma mansoni hypothetical protein 0.0101 0.0532 0.4975
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0172 0.0232
Brugia malayi hypothetical protein 0.0043 0.0204 0.2298
Echinococcus granulosus GPCR family 3 C terminal 0.0018 0.0064 0.0353
Schistosoma mansoni hypothetical protein 0.0012 0.0033 0.031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0201 0.1103
Entamoeba histolytica acyl-CoA synthetase, putative 0.0017 0.0059 0.1351
Mycobacterium leprae Conserved hypothetical protein 0.001 0.0019 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.003 0.0313
Echinococcus multilocularis fat cadherin tumor suppressor 0.0012 0.0033 0.0045
Trypanosoma brucei importin beta-1 subunit, putative 0.0012 0.003 0.0552
Onchocerca volvulus 0.0035 0.0162 0.1747
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0009 0.0017 0.009
Plasmodium falciparum acyl-CoA synthetase 0.0013 0.0035 0.0623
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.0201 0.2267
Echinococcus multilocularis fibrillin 1 0.0032 0.0145 0.0196
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0305 0.0294
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0014 0.0045 0.0494
Schistosoma mansoni hypothetical protein 0.0042 0.0201 0.1877
Leishmania major lanosterol 14-alpha-demethylase, putative 0.001 0.0019 0.024
Echinococcus granulosus glutamate receptor 2 0.001 0.0022 0.0121
Trypanosoma brucei beta lactamase 0.0034 0.0155 0.392
Brugia malayi beta-lactamase 0.0035 0.0162 0.1823
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0166 0.091
Onchocerca volvulus 0.0012 0.0033 0.0339
Brugia malayi Isocitrate dehydrogenase 0.0009 0.0017 0.0169
Onchocerca volvulus 0.0012 0.0033 0.0339
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0013 0.0035 0.0024
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.001 0.0019 0.0008
Brugia malayi Latrophilin receptor protein 2 0.0014 0.0045 0.0494
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.018 0.168
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0059 0.0651
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0021 0.0084 0.1938
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0007 0.0002 0.0012
Schistosoma mansoni hypothetical protein 0.017 0.0918 0.8579
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0381 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.001 0.0019 0.0008
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0162 0.0151
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0062 0.031 0.0298
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0019 0.007 0.0777
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0052 0.0568
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0021 0.008 0.0436
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.006 0.0328
Loa Loa (eye worm) mbt repeat family protein 0.0017 0.0057 0.063
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0057 0.0534
Schistosoma mansoni ferritin 0.0008 0.0012 0.0109
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0059 0.0048
Schistosoma mansoni notch 0.0012 0.0033 0.031
Echinococcus multilocularis notch 0.0012 0.0033 0.0045
Plasmodium vivax acyl-CoA synthetase, putative 0.0013 0.0035 0.0623
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0002 0.0012
Mycobacterium ulcerans hypothetical protein 0.0017 0.0059 0.0048
Leishmania major hypothetical protein, conserved 0.0015 0.005 0.1269
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Brugia malayi Thioredoxin reductase 0.0062 0.031 0.3501
Echinococcus granulosus polycomb protein SCMH1 0.0017 0.0057 0.0315
Trypanosoma cruzi trypanothione reductase, putative 0.0062 0.031 0.8108
Schistosoma mansoni sex comb on midleg homolog 0.0017 0.0057 0.0537
Toxoplasma gondii EGF family domain-containing protein 0.0012 0.0033 0.0803
Onchocerca volvulus 0.0022 0.0086 0.0917
Echinococcus multilocularis 0.0009 0.0013 0.0018
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0021 0.0084 0.2487
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0162 0.0151
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0106 0.2721
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0162 0.0219
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.01 0.0524 0.5944
Mycobacterium tuberculosis Probable reductase 0.014 0.0753 0.0742
Brugia malayi latrophilin 2 splice variant baaae 0.0031 0.014 0.157
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0032 0.0145 0.1358
Entamoeba histolytica polynucleotide kinase-3-phosphatase, putative 0.0074 0.0381 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.014 0.0753 0.0742
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.088 0.4913 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0162 0.1823
Toxoplasma gondii calcium binding egf domain-containing protein 0.0032 0.0145 0.4532
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0009 0.0012 0.0087
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0172 0.1607
Plasmodium falciparum phosphatase, putative 0.0074 0.0381 1
Echinococcus granulosus bifunctional polynucleotide 0.0074 0.0381 0.2089
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.001 0.0019 0.0008
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0009 0.0017 0.0159
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0021 0.0084 0.1938
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.001 0.0019 0.0008
Brugia malayi notch-like transmembrane receptor 0.0012 0.0033 0.0353
Loa Loa (eye worm) hypothetical protein 0.0048 0.0236 0.2667
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0305 0.0294
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.001 0.0019 0.0008
Loa Loa (eye worm) hypothetical protein 0.0041 0.0193 0.2173
Loa Loa (eye worm) Notch2 0.0012 0.0033 0.0353
Echinococcus granulosus GPCR family 2 0.0014 0.0045 0.0249
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0007 0.0002 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0106 0.2721
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.006 0.0081
Brugia malayi hypothetical protein 0.001 0.0022 0.0228
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0201 0.1103
Leishmania major extracellular receptor, putative 0.001 0.0022 0.0332
Schistosoma mansoni hypothetical protein 0.0014 0.0045 0.0425
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.001 0.0019 0.0008
Schistosoma mansoni notch 0.0012 0.0033 0.031
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0381 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0.0002 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.018 0.1876
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0228
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0071 0.0362 0.0351
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0037 0.0025
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.003 0.0135 0.0741
Schistosoma mansoni coup transcription factor 0.0007 0.0002 0.002
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.001 0.0019 0.0008
Echinococcus granulosus glutamate receptor 2 0.001 0.0022 0.0121
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Toxoplasma gondii histone lysine methyltransferase SET1 0.0036 0.0164 0.516
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0172 0.0942
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0009 0.0017 0.0377
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0059 0.0651
Echinococcus granulosus slit 2 protein 0.0012 0.0033 0.0182
Loa Loa (eye worm) hypothetical protein 0.0035 0.0162 0.1823
Echinococcus multilocularis thioredoxin glutathione reductase 0.0062 0.0313 0.0422
Echinococcus multilocularis neural cadherin 0.0012 0.0033 0.0045
Onchocerca volvulus Cell death protein 3 homolog 0.0021 0.0084 0.0891
Echinococcus multilocularis fibropellin Ia 0.0012 0.0033 0.0045
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0021 0.0084 0.2405
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.001 0.0019 0.0008
Schistosoma mansoni hypothetical protein 0.017 0.0918 0.8579
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0228
Brugia malayi Cadherin domain containing protein 0.0012 0.0033 0.0353
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Trypanosoma brucei polo-like protein kinase 0.0038 0.018 0.4583
Schistosoma mansoni tyrosine kinase 0.003 0.0135 0.1265
Brugia malayi Muscle positioning protein 4 0.0012 0.0033 0.0353
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0039 0.0182 0.1702
Echinococcus granulosus fibropellin Ia 0.0012 0.0033 0.0182
Schistosoma mansoni hypothetical protein 0.0125 0.0664 0.6208
Brugia malayi Cytochrome P450 family protein 0.0023 0.0094 0.1048
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0059 0.0048
Plasmodium vivax phosphatase, putative 0.0074 0.0381 1
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.018 0.1876
Brugia malayi Fibulin-1 precursor 0.0032 0.0145 0.163
Schistosoma mansoni ferritin 0.0008 0.0012 0.0109
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0063 0.0697
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.001 0.0019 0.0008
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0017 0.0057 0.1435
Echinococcus granulosus tyrosine kinase 0.0011 0.0025 0.0138
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0032 0.0145 0.163
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0162 0.1685
Brugia malayi DNA 3'-phosphatase family protein 0.0074 0.0381 0.4316
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0084 0.2141
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.001 0.0022 0.003
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.001 0.0022 0.0121
Schistosoma mansoni egf-like domain protein 0.0032 0.0145 0.1358
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0007 0.0002 0.0012
Onchocerca volvulus Neurogenic locus notch homolog 0.0012 0.0033 0.0339
Brugia malayi RNA recognition motif domain containing protein 0.0038 0.0176 0.1984
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0017 0.0059 0.0048
Schistosoma mansoni RAR-like nuclear receptor 0.0007 0.0002 0.002
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.001 0.0019 0.0008
Schistosoma mansoni tyrosine kinase 0.0011 0.0025 0.0236
Loa Loa (eye worm) TK/INSR protein kinase 0.0067 0.0341 0.3852
Onchocerca volvulus 0.0035 0.0162 0.1747
Loa Loa (eye worm) TAR-binding protein 0.0038 0.0176 0.1984
Echinococcus multilocularis GPCR, family 2 0.0014 0.0045 0.0061
Schistosoma mansoni ran 0.0009 0.0012 0.0115
Echinococcus granulosus Tolloid protein 1 0.0032 0.0145 0.0796
Onchocerca volvulus 0.0035 0.0162 0.1747
Echinococcus granulosus atrial natriuretic peptide receptor 0.001 0.0022 0.0121
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0009 0.0017 0.009
Trypanosoma cruzi importin beta-1 subunit, putative 0.0009 0.0017 0.0382
Brugia malayi Muscleblind-like protein 0.0149 0.0804 0.9126
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0017 0.0057 0.1435
Trypanosoma cruzi polynucleotide kinase 3'-phosphatase, putative 0.0074 0.0381 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.006 0.056
Echinococcus multilocularis neurogenic locus notch protein 4 0.0012 0.0033 0.0045
Loa Loa (eye worm) hypothetical protein 0.0039 0.0182 0.2048
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.001 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0162 0.1823
Brugia malayi EGF-like domain containing protein 0.0012 0.0033 0.0353
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0156 0.0841 0.083
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0305 0.0294
Mycobacterium tuberculosis Conserved protein 0.0035 0.0162 0.0151
Onchocerca volvulus 0.0012 0.0033 0.0339
Schistosoma mansoni hypothetical protein 0.0012 0.0033 0.031
Echinococcus multilocularis neurogenic locus notch protein 0.0012 0.0033 0.0045
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0039 0.0182 0.0245
Onchocerca volvulus Slit protein homolog 0.0012 0.0033 0.0339
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0059 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0162 0.4215
Brugia malayi RNA, U transporter 1 0.0033 0.0151 0.1689
Echinococcus granulosus zinc finger protein 0.0021 0.008 0.0436
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0009 0.0017 0.0128
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.018 0.1876
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0172 0.1933
Trichomonas vaginalis CAMK family protein kinase 0.0019 0.0071 0.0683
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0096 0.0527
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0028 0.0037
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0002 0.002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0007 0.0002 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0084 0.2141
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0135 0.0726 0.0978
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.001 0.0019 0.0008
Onchocerca volvulus 0.0012 0.0033 0.0339
Schistosoma mansoni notch 0.0012 0.0033 0.031
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0106 0.3216
Brugia malayi MAP kinase sur-1 0.0017 0.0057 0.0625
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0012 0.0033 0.031
Plasmodium vivax importin-beta 2, putative 0.0012 0.003 0.0469
Echinococcus multilocularis geminin 0.017 0.0918 0.1237
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.001 0.0019 0.0008
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0021 0.0084 0.0072
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0021 0.0084 0.2405
Trypanosoma brucei RNA helicase, putative 0.0042 0.0201 0.515
Onchocerca volvulus 0.0017 0.006 0.0635
Echinococcus granulosus ecdysone induced protein 78C 0.0007 0.0002 0.0012
Mycobacterium tuberculosis Conserved protein 0.0035 0.0162 0.0151
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0021 0.0084 0.2141
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.001 0.0022 0.0121
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0106 0.2532
Echinococcus multilocularis cpg binding protein 0.002 0.0077 0.0103
Schistosoma mansoni ferritin light chain 0.0008 0.0012 0.0109
Schistosoma mansoni hypothetical protein 0.0012 0.0033 0.031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0377
Echinococcus multilocularis SAM and MBT domain containing protein 0.0017 0.0057 0.0077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0017 0.0059 0.0048
Brugia malayi Cytochrome P450 family protein 0.001 0.0019 0.0197
Loa Loa (eye worm) hypothetical protein 0.0011 0.0025 0.0263
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.018 0.1876
Loa Loa (eye worm) hypothetical protein 0.0032 0.0145 0.163
Schistosoma mansoni ferritin 0.0008 0.0012 0.0109
Schistosoma mansoni tyrosine kinase 0.0011 0.0025 0.0236
Echinococcus multilocularis GPCR, family 3, C terminal 0.0018 0.0064 0.0087
Trichomonas vaginalis ferritin, putative 0.0008 0.0012 0.0029
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0007 0.0002 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.001 0.0019 0.0008
Schistosoma mansoni hypothetical protein 0.0011 0.0028 0.0258
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0084 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.001 0.0022 0.0228
Echinococcus multilocularis histone acetyltransferase MYST2 0.0019 0.007 0.0095
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0018 0.0064 0.0679
Plasmodium vivax SET domain protein, putative 0.0022 0.0086 0.2002
Brugia malayi mbt repeat family protein 0.0017 0.0057 0.063
Echinococcus granulosus protein jagged 2 0.0012 0.0033 0.0182
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0228
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0305 0.9858
Plasmodium falciparum glutathione reductase 0.0062 0.031 0.8059
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0172 0.0232
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0021 0.0084 0.0459
Entamoeba histolytica Ran family GTPase 0.0009 0.0012 0.0087
Schistosoma mansoni cpg binding protein 0.0017 0.006 0.0564
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.001 0.0019 0.0008
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.001 0.0022 0.003
Onchocerca volvulus Huntingtin homolog 0.0043 0.0204 0.2203
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0017 0.0057 0.1598
Echinococcus multilocularis protein jagged 1 0.0012 0.0033 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.018 0.1876
Schistosoma mansoni tyrosine kinase 0.003 0.0132 0.1236
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0017 0.0057 0.0604
Trypanosoma cruzi polo-like protein kinase, putative 0.0038 0.018 0.4674
Loa Loa (eye worm) hypothetical protein 0.0012 0.0033 0.0353
Brugia malayi EGF-like domain containing protein 0.0012 0.0033 0.0353
Loa Loa (eye worm) hypothetical protein 0.0149 0.0804 0.9126
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0228
Echinococcus multilocularis ecdysone induced protein 78C 0.0007 0.0002 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0002 0.0003
Mycobacterium tuberculosis Putative ferredoxin reductase 0.014 0.0753 0.0742
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0651
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0038 0.0176 0.1984
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0019 0.0441
Loa Loa (eye worm) isocitrate dehydrogenase 0.0009 0.0017 0.0169
Entamoeba histolytica serine/threonine protein kinase, putative 0.0038 0.018 0.4583
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.001 0.0022 0.0228
Brugia malayi hypothetical protein 0.0015 0.0048 0.052
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0172 0.5368
Loa Loa (eye worm) hypothetical protein 0.0032 0.0145 0.163
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0046 0.0222 0.2497
Trichomonas vaginalis CMGC family protein kinase 0.0017 0.0057 0.0528
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0038 0.018 0.2021
Giardia lamblia NADH oxidase lateral transfer candidate 0.0021 0.0084 0.4273
Echinococcus granulosus neurogenic locus protein delta 0.0012 0.0033 0.0182
Brugia malayi Calcium binding EGF domain containing protein 0.0012 0.0033 0.0353
Echinococcus granulosus caspase 2 0.0021 0.0084 0.0459
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0012 0.0031 0.002
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0162 0.0889
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0017 0.0059 0.0097
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.008 0.0887
Mycobacterium leprae Probable lipase LipE 0.0035 0.0162 0.0307
Leishmania major hypothetical protein, conserved 0.0025 0.0106 0.3142
Brugia malayi EGF-like domain containing protein 0.0012 0.0033 0.0353
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0025 0.0263
Echinococcus granulosus FTZ F1 alpha 0.0007 0.0002 0.0012
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0037 0.0894
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0009 0.0017 0.0159
Echinococcus multilocularis slit 2 protein 0.0012 0.0033 0.0045
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.001 0.0019 0.0008
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0021 0.0084 0.0072
Loa Loa (eye worm) hypothetical protein 0.0028 0.0123 0.1371
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0017 0.0059 0.0097
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0032 0.0145 0.163
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0172 0.0942
Echinococcus granulosus mitogen activated protein kinase 3 0.0017 0.0057 0.0313
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0172 0.9538
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0021 0.0084 0.0072
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0038 0.018 0.0985
Loa Loa (eye worm) beta-lactamase 0.0035 0.0162 0.1823
Toxoplasma gondii isocitrate dehydrogenase 0.0009 0.0017 0.0264
Echinococcus granulosus mitogen activated protein kinase 0.0017 0.0057 0.0313
Giardia lamblia Kinase, CMGC MAPK 0.0017 0.0057 0.2677
Onchocerca volvulus 0.0015 0.0048 0.0498
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0059 0.0048
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0162 0.1823
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0021 0.0084 1
Brugia malayi Calcium binding EGF domain containing protein 0.0012 0.0033 0.0353
Leishmania major 4-coumarate:coa ligase-like protein 0.0017 0.0059 0.1583
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.001 0.0019 0.0008
Schistosoma mansoni tyrosine kinase 0.0067 0.0341 0.3184
Schistosoma mansoni hypothetical protein 0.001 0.0019 0.0182
Brugia malayi Bromodomain containing protein 0.0076 0.0391 0.4429
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.014 0.0753 0.1512
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0018 0.0064 0.0709
Onchocerca volvulus Huntingtin homolog 0.0043 0.0204 0.2203
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0025 0.0263
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0009 0.0017 0.0213
Trypanosoma brucei ISWI complex protein 0.0015 0.005 0.1101
Brugia malayi Calcium binding EGF domain containing protein 0.0032 0.0145 0.163
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0008 0.0009 0.0167
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.0201 0.2267
Loa Loa (eye worm) hypothetical protein 0.0046 0.0222 0.2497
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0162 0.4117
Mycobacterium tuberculosis Probable dehydrogenase 0.014 0.0753 0.0742
Echinococcus granulosus importin subunit beta 1 0.0012 0.003 0.0162
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0305 0.1672
Schistosoma mansoni myelin transcription factor 1 myt1 0.0019 0.007 0.0658
Brugia malayi CXXC zinc finger family protein 0.0017 0.006 0.0662
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0228
Brugia malayi Furin-like cysteine rich region family protein 0.003 0.0135 0.1516
Schistosoma mansoni tyrosine kinase 0.003 0.0132 0.1236
Toxoplasma gondii ABC1 family protein 0.0035 0.0162 0.5097
Leishmania major trypanothione reductase 0.0062 0.031 1
Trypanosoma cruzi ISWI complex protein 0.0015 0.005 0.1249
Loa Loa (eye worm) hypothetical protein 0.0025 0.0106 0.1179
Schistosoma mansoni hypothetical protein 0.0012 0.0033 0.031
Mycobacterium ulcerans beta-lactamase 0.0035 0.0162 0.0151
Echinococcus granulosus metabotropic glutamate receptor 2 0.0092 0.0482 0.2642
Mycobacterium ulcerans acyl-CoA synthetase 0.0017 0.0059 0.0048
Brugia malayi Pre-SET motif family protein 0.0022 0.0086 0.0956

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 6 nM In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex ChEMBL. 10498204
Ki (binding) = 6 nM In vitro evaluation of inhibitory activity against Coagulation factor X in prothrombinase complex ChEMBL. 10498204
Ki (binding) = 6 nM Inhibition of factor 10a ChEMBL. 20503967
Ratio (binding) > 480 Ratio of inhibitory activity against coagulation factor trypsin to that of factor Xa ChEMBL. 10498204
Ratio (binding) > 660 Ratio inhibitory activity against coagulation factor IIa to that of factor Xa ChEMBL. 10498204
Ratio (binding) > 1200 Ratio of inhibitory activity against Plasmin to that of factor Xa ChEMBL. 10498204
Ratio (binding) > 1450 Ratio of inhibitory activity against plasminogen activator to that of factor Xa ChEMBL. 10498204
Ratio (binding) > 3080 Ratio of inhibitory activity against activated protein C to that of factor Xa ChEMBL. 10498204

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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