Detailed information for compound 51640

Basic information

Technical information
  • TDR Targets ID: 51640
  • Name: (4R,5R)-1,3,4-tribenzyl-5-hydroxy-1,3-diazina n-2-one
  • MW: 386.486 | Formula: C25H26N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.9 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(Cc2ccccc2)C[C@H]([C@H](N1Cc1ccccc1)Cc1ccccc1)O
  • InChi: 1S/C25H26N2O2/c28-24-19-26(17-21-12-6-2-7-13-21)25(29)27(18-22-14-8-3-9-15-22)23(24)16-20-10-4-1-5-11-20/h1-15,23-24,28H,16-19H2/t23-,24-/m1/s1
  • InChiKey: GPADBRIUIALHNW-DNQXCXABSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4R,5R)-1,3,4-tribenzyl-5-hydroxy-hexahydropyrimidin-2-one
  • (4R,5R)-1,3,4-tribenzyl-5-hydroxy-2-hexahydropyrimidinone
  • (4R,5R)-5-hydroxy-1,3,4-tris(phenylmethyl)-1,3-diazinan-2-one
  • (4R,5R)-5-hydroxy-1,3,4-tris(phenylmethyl)hexahydropyrimidin-2-one
  • (4R,5R)-5-hydroxy-1,3,4-tris(phenylmethyl)-2-hexahydropyrimidinone
  • (4R,5R)-1,3,4-tris(benzyl)-5-hydroxy-hexahydropyrimidin-2-one
  • (4R,5R)-5-hydroxy-1,3,4-trisbenzyl-1,3-diazaperhydroin-2-one
  • AIDS-058316
  • AIDS058316

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0052
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0006 0.0054
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0383
Echinococcus granulosus tyrosine protein kinase Src64B 0.0041 0.0051 0.0413
Loa Loa (eye worm) heat shock protein 90 0.005 0.0066 0.0638
Trichomonas vaginalis ABC transporter, putative 0.0035 0.004 0.0969
Echinococcus granulosus death domain containing protein 0.0016 0.0009 0.0071
Onchocerca volvulus 0.0018 0.0013 0.0244
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0015 0.0014
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0035 0.0288
Trichomonas vaginalis ABC transporter, putative 0.0035 0.004 0.0969
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0013 0.0244
Schistosoma mansoni jumonji domain containing protein 0.0083 0.012 0.048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Trypanosoma brucei protein kinase, putative 0.0056 0.0075 0.0685
Brugia malayi PHD-finger family protein 0.0014 0.0006 0.0062
Loa Loa (eye worm) heat shock protein 75 0.0033 0.0038 0.0368
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0015 0.0014
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0003 0.0029
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0006 0.0054
Echinococcus multilocularis zinc finger protein 0.0023 0.0021 0.0166
Entamoeba histolytica hypothetical protein 0.004 0.0048 0.7286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0009 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Brugia malayi isocitrate dehydrogenase 0.0017 0.0011 0.011
Mycobacterium ulcerans heat shock protein 90 0.0047 0.006 0.006
Entamoeba histolytica hypothetical protein 0.004 0.0048 0.7286
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0013 0.0316
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0051 0.0413
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0023 0.055
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0389
Echinococcus multilocularis heat shock protein 0.005 0.0066 0.0528
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0013 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0136
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0009 0.0035
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0051 0.0413
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0035 0.004 0.0969
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Loa Loa (eye worm) ctsf protein 0.0018 0.0013 0.0127
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0011 0.0001 0.0002
Plasmodium falciparum heat shock protein 90, putative 0.0029 0.0031 0.1022
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0026 0.0215
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0006 0.0136
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0053 0.0516
Loa Loa (eye worm) hypothetical protein 0.0052 0.0069 0.0669
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0013 0.0127
Brugia malayi Cytochrome P450 family protein 0.0019 0.0015 0.0143
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0041 0.0051 0.0408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0003 0.0457
Mycobacterium leprae Conserved hypothetical protein 0.0019 0.0015 0.0029
Onchocerca volvulus 0.0018 0.0013 0.0244
Trichomonas vaginalis set domain proteins, putative 0.0261 0.0412 1
Echinococcus multilocularis lamin dm0 0.003 0.0031 0.0251
Echinococcus granulosus lamin 0.003 0.0031 0.0256
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0018 0.06
Trypanosoma cruzi heat shock protein 90, putative 0.0043 0.0054 0.0489
Echinococcus granulosus tyrosine protein kinase Lyn 0.0042 0.0052 0.042
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0011 0.0087
Onchocerca volvulus 0.0033 0.0038 0.0851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0003 0.0073
Schistosoma mansoni rab6-interacting 0.0022 0.0018 0.0074
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0009 0.0085
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0014 0.0054
Leishmania major cytochrome p450-like protein 0.0019 0.0015 0.013
Plasmodium falciparum endoplasmin, putative 0.0037 0.0043 0.1426
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0014 0.0105
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0013 0.0101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Echinococcus multilocularis heat shock protein 90 0.0043 0.0054 0.0431
Brugia malayi bHLH-PAS transcription factor 0.004 0.0048 0.0466
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0042 0.0343
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Schistosoma mansoni hypothetical protein 0.0016 0.0009 0.0035
Leishmania major heat shock protein, putative 0.0033 0.0038 0.0343
Brugia malayi ABC transporter 0.0011 0.0001 0.0006
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0073 0.0672
Mycobacterium leprae putative cytochrome p450 0.0019 0.0015 0.0029
Loa Loa (eye worm) hypothetical protein 0.0045 0.0056 0.0549
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0031 0.0307
Brugia malayi Pre-SET motif family protein 0.0229 0.036 0.3507
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0041 0.0051 0.0408
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.0015 0.0014
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0088 0.0807
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0015 0.0014
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0035 0.004 0.032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0069 0.0275
Schistosoma mansoni cpg binding protein 0.0035 0.0041 0.0165
Onchocerca volvulus 0.0018 0.0013 0.0244
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0006 0.0045
Trypanosoma brucei heat shock protein 90, putative 0.005 0.0066 0.0599
Brugia malayi intermediate filament protein 0.003 0.0031 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Schistosoma mansoni multidrug resistance protein 0.0011 0.0001 0.0002
Schistosoma mansoni tyrosine kinase 0.0041 0.0051 0.0204
Toxoplasma gondii heat shock protein HSP90 0.005 0.0066 0.2194
Brugia malayi Death domain containing protein 0.0016 0.0009 0.0085
Entamoeba histolytica ABC transporter, putative 0.0011 0.0001 0.0095
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.0087
Loa Loa (eye worm) cysteine protease 0.0018 0.0013 0.0127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0006
Schistosoma mansoni multidrug resistance protein 0.0011 0.0001 0.0002
Entamoeba histolytica P-glycoprotein 6, putative 0.0011 0.0001 0.0095
Echinococcus granulosus endoplasmin 0.0047 0.006 0.0492
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.0015 0.0014
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0013 0.0106
Echinococcus multilocularis heat shock protein 90 0.005 0.0066 0.0528
Entamoeba histolytica ATP-binding cassette protein, putative 0.0011 0.0001 0.0095
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0006 0.004
Giardia lamblia Multidrug resistance-associated protein 1 0.0011 0.0001 0.0083
Brugia malayi ABC transporter transmembrane region family protein 0.0011 0.0001 0.0006
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0041 0.0051 0.0408
Schistosoma mansoni tyrosine kinase 0.0041 0.0051 0.0204
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0087 0.293
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0013 0.0244
Trichomonas vaginalis abcb9, putative 0.0035 0.004 0.0969
Brugia malayi jmjC domain containing protein 0.0043 0.0053 0.0516
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0009 0.0066
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0006 0.0046
Schistosoma mansoni multidrug resistance protein 0.0011 0.0001 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0075 0.03
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0043 0.104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Onchocerca volvulus 0.0022 0.0018 0.0376
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0669 0.1084 1
Schistosoma mansoni multidrug resistance protein 0.0011 0.0001 0.0002
Brugia malayi CXXC zinc finger family protein 0.0032 0.0035 0.0337
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0013 0.0127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0038 0.0152
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0669 0.1084 1
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0033 0.0038 0.576
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0018 0.0149
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0095 0.038
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0009 0.0086
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0114
Onchocerca volvulus 0.0018 0.0013 0.0244
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0015 0.0014
Schistosoma mansoni loxhd1 0.0022 0.0018 0.0074
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0015 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0015 0.0014
Toxoplasma gondii heat shock protein 75, putative 0.0033 0.0038 0.1255
Schistosoma mansoni single-minded 0.0053 0.0071 0.0283
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0051 0.0408
Brugia malayi ABC transporter family protein 0.0011 0.0001 0.0006
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0298
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0085
Brugia malayi hypothetical protein 0.0022 0.0018 0.0179
Brugia malayi MAP kinase sur-1 0.0056 0.0075 0.0729
Entamoeba histolytica hypothetical protein 0.004 0.0048 0.7286
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0035 0.1176
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0034 0.0039 0.0319
Leishmania major cytochrome p450-like protein 0.0019 0.0015 0.013
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0127
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0015 0.0014
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0114
Toxoplasma gondii cathepsin CPL 0.0018 0.0013 0.0418
Schistosoma mansoni hypothetical protein 0.0022 0.0018 0.0074
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0071 0.0283
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0127
Leishmania major cathepsin L-like protease 0.007 0.0098 0.0899
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0006 0.0045
Echinococcus multilocularis peregrin 0.0035 0.004 0.0318
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.2496 1
Brugia malayi SRC-1 0.0041 0.0051 0.0495
Loa Loa (eye worm) hypoxia-induced factor 1 0.0165 0.0255 0.2482
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.0044 0.0359
Schistosoma mansoni multidrug resistance protein 0.0035 0.004 0.016
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0035 0.004 0.032
Entamoeba histolytica P-glycoprotein-1 0.0035 0.004 0.6088
Schistosoma mansoni lipoxygenase 0.013 0.0196 0.0785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0011 0.0011
Loa Loa (eye worm) fibroinase 0.0018 0.0013 0.0127
Echinococcus multilocularis Ankyrin 0.0016 0.0009 0.0068
Loa Loa (eye worm) SRC-1 0.0041 0.0051 0.0495
Loa Loa (eye worm) endoplasmin 0.005 0.0066 0.0638
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.0051 0.0408
Schistosoma mansoni hypothetical protein 0.0019 0.0015 0.0059
Brugia malayi Protein kinase domain containing protein 0.0016 0.001 0.0093
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0035 0.004 0.032
Brugia malayi P-glycoprotein-like protein 0.0011 0.0001 0.0006
Onchocerca volvulus 0.0261 0.0412 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0011 0.036
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0035 0.0337
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.0155 0.1258
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0013 0.0052
Brugia malayi Bromodomain containing protein 0.0035 0.004 0.0387
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0001 0.0006
Brugia malayi Uncoordinated protein 44 0.0016 0.0009 0.0085
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0053 0.043
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0035 0.0345
Echinococcus multilocularis cpg binding protein 0.0035 0.0041 0.0329
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0006 0.005
Schistosoma mansoni multidrug resistance protein 0.0035 0.004 0.016
Brugia malayi Cytochrome P450 family protein 0.0029 0.0031 0.0298
Trypanosoma brucei ISWI complex protein 0.0017 0.001 0.009
Echinococcus granulosus intermediate filament protein 0.003 0.0031 0.0256
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0048 0.0388
Entamoeba histolytica P-glyco protein 6, putative 0.0035 0.004 0.6088
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0035 0.0283
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0011 0.0001 0.0006
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.0015 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0013 0.0114
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0018 0.0179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.0015 0.0014
Brugia malayi PHD-finger family protein 0.0032 0.0035 0.0345
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0066 0.0599
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0033 0.0038 0.0302
Schistosoma mansoni netrin receptor unc5 0.0016 0.0009 0.0035
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0669 0.1084 0.1084
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.0015 0.0014
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0066 0.0599
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0006 0.0136
Entamoeba histolytica P-glycoprotein-2 0.0035 0.004 0.6088
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0013 0.0052
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0015 0.0014
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0003 0.0012
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0023 0.0184
Plasmodium vivax multidrug resistance protein 1, putative 0.0035 0.004 0.1327
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0078 0.0111 0.1077
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0013 0.1983
Trypanosoma brucei Heat shock protein 83, putative 0.005 0.0066 0.0599
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0035 0.004 0.0324
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Leishmania major cathepsin L-like protease 0.007 0.0098 0.0899
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0009 0.0071
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0029
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0092 0.0892
Onchocerca volvulus 0.0032 0.0035 0.0773
Mycobacterium ulcerans putative regulatory protein 0.004 0.0048 0.0047
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0035 0.004 0.0969
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0062
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Schistosoma mansoni multidrug resistance protein 0.0011 0.0001 0.0002
Trichomonas vaginalis abcb9, putative 0.0035 0.004 0.0969
Onchocerca volvulus 0.0018 0.0013 0.0244
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0006 0.0136
Brugia malayi ABC transporter family protein 0.0011 0.0001 0.0006
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0075 0.0685
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0094 0.0761
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.0015 0.0014
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0011 0.0098
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.0015 0.0014
Brugia malayi ABC transporter transmembrane region family protein 0.0011 0.0001 0.0006
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Trichomonas vaginalis ABC transporter, putative 0.0035 0.004 0.0969
Echinococcus multilocularis geminin 0.0186 0.0289 0.2346
Onchocerca volvulus 0.003 0.0031 0.0696
Echinococcus granulosus ATP binding cassette sub family B 0.0011 0.0001 0.0005
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0011 0.011
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0035 0.004 0.0363
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0013 0.0114
Echinococcus multilocularis multidrug resistance protein 1 0.0035 0.004 0.032
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.0037 0.0299
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0041 0.0051 0.0408
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0015 0.0059
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0047 0.006 0.0122
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0014 0.011
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0041 0.0051 0.0408
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0011 0.036
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0017 0.0155
Loa Loa (eye worm) multidrug resistance protein 3 0.0035 0.004 0.0389
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.0015 0.0014
Plasmodium falciparum phd finger protein, putative 0.0032 0.0035 0.1176
Echinococcus granulosus zinc finger protein 0.0023 0.0021 0.0171
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.0015 0.0014
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0035 0.004 0.0969
Brugia malayi Doublecortin family protein 0.0022 0.0018 0.0179
Plasmodium vivax heat shock protein 86, putative 0.005 0.0066 0.2194
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0069 0.0553
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0011 0.0098
Brugia malayi jmjC domain containing protein 0.0105 0.0155 0.1513
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.0044 0.0354
Entamoeba histolytica heat shock protein 90, putative 0.005 0.0066 1
Echinococcus granulosus ATP binding cassette sub family B 0.0011 0.0001 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0075 0.1816
Giardia lamblia ABC transporter, putative 0.0011 0.0001 0.0083
Trichomonas vaginalis abcb9, putative 0.0035 0.004 0.0969
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.0015 0.0014
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0006 0.0046
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0023 0.0184
Echinococcus granulosus heat shock protein 90 0.005 0.0066 0.0533
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0098 0.0899
Echinococcus granulosus arachidonate 5 lipoxygenase 0.013 0.0196 0.1593
Onchocerca volvulus 0.0035 0.004 0.0902
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0033 0.0038 0.0307
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0015 0.0014
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0098 0.0899
Entamoeba histolytica multidrug resistance protein, putative 0.0011 0.0001 0.0095
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0031 0.0276
Schistosoma mansoni hypothetical protein 0.0023 0.002 0.008
Brugia malayi ABC transporter family protein 0.0035 0.004 0.0389
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0075 0.0604
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0015 0.0014
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Loa Loa (eye worm) TK protein kinase 0.0037 0.0044 0.043
Trichomonas vaginalis ABC transporter, putative 0.0035 0.004 0.0969
Brugia malayi multidrug resistance related protein 1 0.0011 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0054
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0179
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0069 0.0558
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0026 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0136
Brugia malayi Cytochrome P450 family protein 0.0029 0.0031 0.0298
Echinococcus multilocularis ATP binding cassette sub family B 0.0034 0.0039 0.0314
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0031 0.0298
Onchocerca volvulus Alhambra homolog 0.0032 0.0035 0.0793
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0001 0.0008
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0006 0.0054
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0006 0.0045
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0047 0.006 0.006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0009 0.0085
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0127
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Echinococcus granulosus cpg binding protein 0.0035 0.0041 0.0334
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.0015 0.0014
Entamoeba histolytica P-glycoprotein 6, putative 0.0011 0.0001 0.0095
Schistosoma mansoni hypothetical protein 0.0186 0.0289 0.1158
Brugia malayi PAS domain containing protein 0.0053 0.0071 0.0688
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0051 0.0408
Echinococcus multilocularis RUN 0.0022 0.0018 0.0144
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0029
Schistosoma mansoni endoplasmin 0.005 0.0066 0.0263
Entamoeba histolytica ATP-binding cassette protein, putative 0.0011 0.0001 0.0095
Onchocerca volvulus 0.0022 0.0018 0.0376
Trypanosoma brucei heat shock protein 84, putative 0.0033 0.0038 0.0343
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0041 0.0051 0.0413
Schistosoma mansoni hypothetical protein 0.0017 0.001 0.0042
Brugia malayi Hsp90 protein 0.0033 0.0038 0.0368
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0011 0.0098
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0043 0.0054 0.0436
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0038 0.1257
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0127
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0035 0.004 0.032
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0021 0.0207
Entamoeba histolytica heat shock protein 90, putative 0.005 0.0066 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0018 0.0149
Loa Loa (eye worm) hypothetical protein 0.0179 0.0278 0.2705
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0015 0.0014
Loa Loa (eye worm) ABC transporter 0.0011 0.0001 0.0006
Echinococcus multilocularis endoplasmin 0.0047 0.006 0.0487
Trichomonas vaginalis heat shock protein, putative 0.0047 0.006 0.1468
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0035 0.004 0.1327
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0136
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0038 0.0303
Schistosoma mansoni polycystin 1-related 0.0022 0.0018 0.0074
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0048 0.0384
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0035 0.004 0.0324
Trichomonas vaginalis taga, putative 0.0035 0.004 0.0969
Echinococcus granulosus peregrin 0.0035 0.004 0.0323
Onchocerca volvulus 0.0018 0.0013 0.0244
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0051 0.0413
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.0015 0.0014
Giardia lamblia Multidrug resistance-associated protein 1 0.0011 0.0001 0.0083
Trypanosoma cruzi heat shock protein 90, putative 0.005 0.0066 0.0599
Entamoeba histolytica hypothetical protein 0.004 0.0048 0.7286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Echinococcus granulosus geminin 0.0186 0.0289 0.235
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0006 0.0046
Leishmania major protein kinase, putative 0.0014 0.0006 0.0054
Schistosoma mansoni multidrug resistance protein 0.0035 0.004 0.016
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0013 0.0418
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0669 0.1084 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0048 0.0383
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Echinococcus multilocularis musashi 0.003 0.0031 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Echinococcus granulosus cathepsin l1 0.0018 0.0013 0.0106
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0006 0.004
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0023 0.0179
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.6089 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0015 0.0014
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0075 0.1816
Brugia malayi hypothetical protein 0.0022 0.0018 0.0179
Brugia malayi cathepsin L-like precursor 0.0012 0.0003 0.0029
Brugia malayi Bromodomain containing protein 0.0042 0.0052 0.0506
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Brugia malayi PHD-finger family protein 0.0029 0.0031 0.0299
Echinococcus granulosus tyrosine kinase 0.0037 0.0044 0.0359
Schistosoma mansoni intermediate filament proteins 0.003 0.0031 0.0126
Schistosoma mansoni smdr2 0.0035 0.004 0.016
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0035 0.004 0.0389
Entamoeba histolytica P-glycoprotein-2 0.0035 0.004 0.6088
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0011 0.0045
Plasmodium vivax heat shock protein, putative 0.0191 0.0297 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0015 0.0476
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0075 0.0685
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.0092
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0056 0.0451
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0055 0.0073 0.0712
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0006 0.0046
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0075 0.0685
Echinococcus granulosus dnaJ subfamily B 0.045 0.0722 0.587
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0669 0.1084 0.1084
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.0155 0.1263
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0031 0.0276
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Brugia malayi Pre-SET motif family protein 0.0033 0.0038 0.0368
Plasmodium vivax endoplasmin, putative 0.005 0.0066 0.2194
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0011 0.0001 0.0006
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0011 0.036
Schistosoma mansoni lipoxygenase 0.0091 0.0132 0.0528
Brugia malayi hypothetical protein 0.004 0.0048 0.0465
Echinococcus granulosus multidrug resistance protein 1 0.0035 0.004 0.0324
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0042 0.0339
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0013 0.0127
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0053 0.0212
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0035 0.004 0.0969
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0053 0.0212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Giardia lamblia Grp94/Hsp90 0.0047 0.006 0.808
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0345
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0015 0.0014
Plasmodium falciparum heat shock protein 90 0.005 0.0066 0.2194
Brugia malayi multidrug resistance protein 3 0.0035 0.004 0.0389
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Schistosoma mansoni hypothetical protein 0.004 0.0048 0.0191
Brugia malayi hypothetical protein 0.0011 0.0001 0.0006
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Brugia malayi Bromodomain containing protein 0.0084 0.0121 0.1181
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0075 1
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0035 0.004 1
Schistosoma mansoni bromodomain containing protein 0.0071 0.01 0.0401
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0114
Echinococcus multilocularis dnaJ subfamily B 0.045 0.0722 0.5868
Brugia malayi cytochrome P450 0.0019 0.0015 0.0143
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0035 0.004 0.0324
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0015 0.0014
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.044 0.1762
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Loa Loa (eye worm) TK protein kinase 0.0033 0.0037 0.0364
Onchocerca volvulus 0.003 0.0031 0.0696
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0035 0.004 0.032
Echinococcus granulosus Ankyrin 0.0016 0.0009 0.0073
Entamoeba histolytica protein kinase, putative 0.0033 0.0037 0.5697
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Schistosoma mansoni endoplasmin 0.005 0.0066 0.0263
Leishmania major protein kinase, putative 0.0014 0.0006 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Loa Loa (eye worm) intermediate filament protein 0.003 0.0031 0.0307
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.3003 0.4923 1
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0075 0.1816
Onchocerca volvulus 0.0014 0.0006 0.0063
Echinococcus multilocularis 0.0019 0.0015 0.0115
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0018 0.0144
Entamoeba histolytica P-glycoprotein-5 0.0035 0.004 0.6088
Entamoeba histolytica P-glycoprotein 5, putative 0.0035 0.004 0.6088
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0048 0.0191
Giardia lamblia Heat shock protein HSP 90-alpha 0.0043 0.0054 0.7161
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0035 0.1176
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.0044 0.0354
Loa Loa (eye worm) hypothetical protein 0.0635 0.1027 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0018 0.0144
Echinococcus granulosus multidrug resistance associated protein 1 0.0011 0.0001 0.0005
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0013 0.0106
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Echinococcus granulosus RUN 0.0022 0.0018 0.0149
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0029
Echinococcus granulosus cathepsin l1 0.0012 0.0003 0.0024
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0018 0.06
Brugia malayi hypoxia-induced factor 1 0.0165 0.0255 0.2482
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0127
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0116 0.0942
Schistosoma mansoni heat shock protein 0.0033 0.0038 0.0151
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0015 0.0014
Onchocerca volvulus 0.004 0.0048 0.1095
Mycobacterium leprae Possible regulatory protein 0.0014 0.0006 0.001
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0015 0.012
Giardia lamblia Heat shock protein HSP 90-alpha 0.005 0.0066 0.876
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0075 0.0608
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0075 0.0685
Leishmania major cathepsin L-like protease 0.007 0.0098 0.0899
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0026 0.0106
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0087
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0009 0.0071
Schistosoma mansoni lamin 0.003 0.0031 0.0126
Loa Loa (eye worm) ABC transporter 0.0011 0.0001 0.0006
Leishmania major cytochrome p450-like protein 0.0029 0.0031 0.0276
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0013 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0047 0.0373
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0011 0.0087
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0051 0.0408
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0003 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0114
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0013 0.0418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Echinococcus granulosus multidrug resistance protein 1 0.0035 0.004 0.0324
Entamoeba histolytica P-glycoprotein-2, putative 0.0035 0.004 0.6088
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0031 0.0298
Brugia malayi Cathepsin L-like precursor 0.0012 0.0003 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0035 0.1176
Plasmodium vivax heat shock protein 90, putative 0.0033 0.0038 0.1255
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0011 0.0098
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0031 0.003
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0031 0.0749
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0094 0.0756
Brugia malayi Cytochrome P450 family protein 0.0019 0.0015 0.0143
Echinococcus multilocularis multidrug resistance protein 1 0.0035 0.004 0.032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.036 0.3507
Brugia malayi heat shock protein 90 0.005 0.0066 0.0638
Trypanosoma cruzi ISWI complex protein 0.0017 0.001 0.009
Giardia lamblia MRP-like ABC transporter 0.0011 0.0001 0.0083
Plasmodium falciparum heat shock protein 90, putative 0.0191 0.0297 1
Echinococcus granulosus heat shock protein 90 0.0043 0.0054 0.0436
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0031 0.0276
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0098 0.0899
Echinococcus multilocularis cysteine protease 0.0018 0.0013 0.0101
Schistosoma mansoni cpg binding protein 0.0032 0.0035 0.0139
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0069 0.0275
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0035 0.004 0.0969
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.0015 0.0014
Plasmodium vivax vivapain-2 0.0018 0.0013 0.0418
Plasmodium falciparum multidrug resistance protein 1 0.0035 0.004 0.1327
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0011 0.011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0035 0.0282
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0009 0.0066
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0035 0.0142
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0011 0.036
Echinococcus multilocularis microtubule associated protein 2 0.0758 0.123 1
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0015 0.0143
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0048 0.0383
Echinococcus granulosus microtubule associated protein 2 0.0758 0.123 1
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0015 0.0014
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0001 0.0015
Brugia malayi Endoplasmin precursor 0.005 0.0066 0.0638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Schistosoma mansoni hypothetical protein 0.0032 0.0035 0.0142
Plasmodium vivax SET domain protein, putative 0.0033 0.0038 0.1257
Echinococcus granulosus heat shock protein 0.005 0.0066 0.0533
Schistosoma mansoni rab6-interacting 0.0022 0.0018 0.0074
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0009 0.0086
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0006 0.0054
Schistosoma mansoni cytochrome P450 0.0019 0.0015 0.0059
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.013 0.0196 0.1588
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0003 0.0084
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0013 0.0418
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0179
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0001 0.0001
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0006 0.0136
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0014 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0015 0.0143
Trypanosoma cruzi ISWI complex protein 0.0017 0.001 0.009
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Brugia malayi hypothetical protein 0.0179 0.0278 0.2705
Leishmania major hypothetical protein, conserved 0.0017 0.001 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Loa Loa (eye worm) hypothetical protein 0.003 0.0031 0.0307
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0015 0.0014
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0018 0.0149
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0075 0.1816
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0047 0.006 0.0552
Schistosoma mansoni lamin 0.003 0.0031 0.0126
Echinococcus granulosus single minded 2 0.004 0.0048 0.0389
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0033 0.0038 0.0849
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0041 0.0051 0.0413
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.0015 0.0014
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0009 0.014
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.0044 0.0359
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0127
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0048 0.0388
Onchocerca volvulus 0.0018 0.0013 0.0244
Plasmodium vivax vivapain-2 0.0018 0.0013 0.0418
Schistosoma mansoni hypothetical protein 0.045 0.0722 0.2893
Entamoeba histolytica hypothetical protein 0.0011 0.0001 0.0095
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0003 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0006 0.0051
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0006 0.0136
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0013 0.0101
Schistosoma mansoni zinc finger protein 0.0023 0.0021 0.0084
Brugia malayi ABC transporter family protein 0.0011 0.0001 0.0006
Schistosoma mansoni hypothetical protein 0.0057 0.0076 0.0305
Schistosoma mansoni hypothetical protein 0.0186 0.0289 0.1158
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0035 0.004 0.0324
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0061
Echinococcus granulosus multidrug resistance protein 1 0.0035 0.004 0.0324
Trichomonas vaginalis endoplasmin, putative 0.0037 0.0043 0.104
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0006 0.0136
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0044 0.0354
Treponema pallidum heat shock protein 90 0.0047 0.006 0.5
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0127
Loa Loa (eye worm) hypothetical protein 0.0042 0.0052 0.0507
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0054 0.1301
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0006 0.0136
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0035 0.004 0.0969
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.0087
Trypanosoma brucei heat shock protein 90, putative 0.005 0.0066 0.0599
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0075 0.0685
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0056 0.0456
Entamoeba histolytica ATP-binding cassette protein, putative 0.0011 0.0001 0.0095
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.0037 0.0304
Toxoplasma gondii heat shock protein 90, putative 0.005 0.0066 0.2194
Entamoeba histolytica ATP-binding cassette protein, putative 0.0011 0.0001 0.0095
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0006 0.0054
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0035 0.004 0.1327
Trichomonas vaginalis heat shock protein, putative 0.005 0.0066 0.1591
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.1983
Toxoplasma gondii Hsp90 domain-containing protein 0.0191 0.0297 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0075 0.2507
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0075 0.0685
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0035 0.004 0.0039
Giardia lamblia PHD finger protein 15 0.0032 0.0035 0.4735
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0075 0.0685
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0669 0.1084 1
Trypanosoma cruzi heat shock protein, putative 0.0033 0.0038 0.0343
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0075 0.0608
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Echinococcus granulosus multidrug resistance associated protein 7 0.0011 0.0001 0.0005
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0015 0.013
Trypanosoma cruzi heat shock protein 85, putative 0.0043 0.0054 0.0489
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0389
Schistosoma mansoni heat shock protein 0.005 0.0066 0.0263
Schistosoma mansoni cpg binding protein 0.0035 0.0041 0.0165
Schistosoma mansoni heat shock protein 0.005 0.0066 0.0263
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0038 0.0152
Echinococcus multilocularis lamin 0.003 0.0031 0.0251
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.0051 0.0413
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0116 0.0937
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0075 0.0604
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0066 0.0599
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0098 0.0899
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0047 0.006 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.0015 0.0014
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0011 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Trichomonas vaginalis heat shock protein, putative 0.0047 0.006 0.1468
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0031 0.0298
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0013 0.0101
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0031 0.0307
Schistosoma mansoni smdr1 0.0011 0.0001 0.0002
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0018 0.0144
Leishmania major p-glycoprotein 0.0035 0.004 0.0363
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0013 0.0101
Loa Loa (eye worm) hypothetical protein 0.0049 0.0063 0.0611
Echinococcus multilocularis cysteine protease 0.0018 0.0013 0.0101
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0006
Schistosoma mansoni microtubule-associated protein tau 0.0758 0.123 0.4929
Loa Loa (eye worm) cytochrome P450 0.0019 0.0015 0.0143
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0075 0.0729
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0035 0.004 0.0969
Schistosoma mansoni zinc finger protein 0.0017 0.001 0.0042
Echinococcus granulosus lamin dm0 0.003 0.0031 0.0256
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.0015 0.0014
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.002 0.0195
Brugia malayi protein-tyrosine kinase 0.0037 0.0044 0.043
Brugia malayi Cathepsin L-like precursor 0.0012 0.0003 0.0029
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0006 0.0136
Trypanosoma cruzi Heat shock protein 83, putative 0.005 0.0066 0.0599
Brugia malayi small heat shock protein 0.0635 0.1027 1
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Loa Loa (eye worm) ABC transporter 0.0011 0.0001 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0013 0.1983

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2.5 nM Compound was tested for the inhibitory activity against HIV-protease ChEMBL. No reference
Ki (binding) = 2.5 nM Compound was tested for the inhibitory activity against HIV-protease ChEMBL. No reference
Ki (binding) = 2400 nM Inhibition constant of HIV protease inhibitors ChEMBL. 9888839
Ki (binding) = 2400 nM Inhibition constant of HIV protease inhibitors ChEMBL. 9888839

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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