Detailed information for compound 255161

Basic information

Technical information
  • TDR Targets ID: 255161
  • Name: (4R,5S)-1,3,4-tribenzyl-5-hydroxy-1,3-diazina n-2-one
  • MW: 386.486 | Formula: C25H26N2O2
  • H donors: 1 H acceptors: 2 LogP: 3.9 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(Cc2ccccc2)C[C@@H]([C@H](N1Cc1ccccc1)Cc1ccccc1)O
  • InChi: 1S/C25H26N2O2/c28-24-19-26(17-21-12-6-2-7-13-21)25(29)27(18-22-14-8-3-9-15-22)23(24)16-20-10-4-1-5-11-20/h1-15,23-24,28H,16-19H2/t23-,24+/m1/s1
  • InChiKey: GPADBRIUIALHNW-RPWUZVMVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4R,5S)-1,3,4-tribenzyl-5-hydroxy-hexahydropyrimidin-2-one
  • (4R,5S)-1,3,4-tribenzyl-5-hydroxy-2-hexahydropyrimidinone
  • (4R,5S)-5-hydroxy-1,3,4-tris(phenylmethyl)-1,3-diazinan-2-one
  • (4R,5S)-5-hydroxy-1,3,4-tris(phenylmethyl)hexahydropyrimidin-2-one
  • (4R,5S)-5-hydroxy-1,3,4-tris(phenylmethyl)-2-hexahydropyrimidinone
  • (4R,5S)-1,3,4-tris(benzyl)-5-hydroxy-hexahydropyrimidin-2-one
  • (5S,4R)-5-Hydroxy-1,3,4-trisbenzyl-1,3-diazaperhydroin-2-one
  • AIDS-060331
  • AIDS060331

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Entamoeba histolytica P-glycoprotein-1 0.0035 0.004 0.6088
Schistosoma mansoni lipoxygenase 0.013 0.0196 0.0785
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0035 0.004 0.032
Schistosoma mansoni multidrug resistance protein 0.0035 0.004 0.016
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.0044 0.0359
Loa Loa (eye worm) hypoxia-induced factor 1 0.0165 0.0255 0.2482
Brugia malayi SRC-1 0.0041 0.0051 0.0495
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.2496 1
Echinococcus multilocularis peregrin 0.0035 0.004 0.0318
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0006 0.0045
Leishmania major cathepsin L-like protease 0.007 0.0098 0.0899
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0127
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0071 0.0283
Schistosoma mansoni hypothetical protein 0.0022 0.0018 0.0074
Toxoplasma gondii cathepsin CPL 0.0018 0.0013 0.0418
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0019 0.0015 0.0014
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0114
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0127
Leishmania major cytochrome p450-like protein 0.0019 0.0015 0.013
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0034 0.0039 0.0319
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0035 0.1176
Entamoeba histolytica hypothetical protein 0.004 0.0048 0.7286
Brugia malayi MAP kinase sur-1 0.0056 0.0075 0.0729
Brugia malayi hypothetical protein 0.0022 0.0018 0.0179
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0085
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0298
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0019 0.0015 0.0014
Brugia malayi ABC transporter family protein 0.0011 0.0001 0.0006
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0051 0.0408
Schistosoma mansoni single-minded 0.0053 0.0071 0.0283
Toxoplasma gondii heat shock protein 75, putative 0.0033 0.0038 0.1255
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0019 0.0015 0.0014
Schistosoma mansoni loxhd1 0.0022 0.0018 0.0074
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0019 0.0015 0.0014
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0019 0.0015 0.0014
Onchocerca volvulus 0.0018 0.0013 0.0244
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0114
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0009 0.0086
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0095 0.038
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0018 0.0149
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0033 0.0038 0.576
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0669 0.1084 1
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0013 0.0127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0038 0.0152
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0669 0.1084 1
Schistosoma mansoni multidrug resistance protein 0.0011 0.0001 0.0002
Brugia malayi CXXC zinc finger family protein 0.0032 0.0035 0.0337
Onchocerca volvulus 0.0022 0.0018 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0075 0.03
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0043 0.104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Schistosoma mansoni multidrug resistance protein 0.0011 0.0001 0.0002
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0009 0.0066
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0006 0.0046
Brugia malayi jmjC domain containing protein 0.0043 0.0053 0.0516
Trichomonas vaginalis abcb9, putative 0.0035 0.004 0.0969
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0013 0.0244
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0087 0.293
Schistosoma mansoni tyrosine kinase 0.0041 0.0051 0.0204
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0041 0.0051 0.0408
Brugia malayi ABC transporter transmembrane region family protein 0.0011 0.0001 0.0006
Giardia lamblia Multidrug resistance-associated protein 1 0.0011 0.0001 0.0083
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0006 0.004
Entamoeba histolytica ATP-binding cassette protein, putative 0.0011 0.0001 0.0095
Echinococcus multilocularis heat shock protein 90 0.005 0.0066 0.0528
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0013 0.0106
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0019 0.0015 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Echinococcus granulosus endoplasmin 0.0047 0.006 0.0492
Entamoeba histolytica P-glycoprotein 6, putative 0.0011 0.0001 0.0095
Schistosoma mansoni multidrug resistance protein 0.0011 0.0001 0.0002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0006
Loa Loa (eye worm) cysteine protease 0.0018 0.0013 0.0127
Brugia malayi Death domain containing protein 0.0016 0.0009 0.0085
Entamoeba histolytica ABC transporter, putative 0.0011 0.0001 0.0095
Toxoplasma gondii heat shock protein HSP90 0.005 0.0066 0.2194
Schistosoma mansoni tyrosine kinase 0.0041 0.0051 0.0204
Schistosoma mansoni multidrug resistance protein 0.0011 0.0001 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Brugia malayi intermediate filament protein 0.003 0.0031 0.0307
Trypanosoma brucei heat shock protein 90, putative 0.005 0.0066 0.0599
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0006 0.0045
Onchocerca volvulus 0.0018 0.0013 0.0244
Schistosoma mansoni cpg binding protein 0.0035 0.0041 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0069 0.0275
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0035 0.004 0.032
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0088 0.0807
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0019 0.0015 0.0014
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0019 0.0015 0.0014
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0041 0.0051 0.0408
Mycobacterium leprae putative cytochrome p450 0.0019 0.0015 0.0029
Brugia malayi Pre-SET motif family protein 0.0229 0.036 0.3507
Loa Loa (eye worm) hypothetical protein 0.0045 0.0056 0.0549
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0031 0.0307
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0073 0.0672
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Schistosoma mansoni hypothetical protein 0.0016 0.0009 0.0035
Brugia malayi ABC transporter 0.0011 0.0001 0.0006
Brugia malayi bHLH-PAS transcription factor 0.004 0.0048 0.0466
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0042 0.0343
Leishmania major heat shock protein, putative 0.0033 0.0038 0.0343
Echinococcus multilocularis heat shock protein 90 0.0043 0.0054 0.0431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0013 0.0101
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0014 0.0105
Leishmania major cytochrome p450-like protein 0.0019 0.0015 0.013
Plasmodium falciparum endoplasmin, putative 0.0037 0.0043 0.1426
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0014 0.0054
Schistosoma mansoni rab6-interacting 0.0022 0.0018 0.0074
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0009 0.0085
Onchocerca volvulus 0.0033 0.0038 0.0851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0003 0.0073
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0011 0.0087
Echinococcus granulosus tyrosine protein kinase Lyn 0.0042 0.0052 0.042
Trypanosoma cruzi heat shock protein 90, putative 0.0043 0.0054 0.0489
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0018 0.06
Echinococcus multilocularis lamin dm0 0.003 0.0031 0.0251
Echinococcus granulosus lamin 0.003 0.0031 0.0256
Trichomonas vaginalis set domain proteins, putative 0.0261 0.0412 1
Onchocerca volvulus 0.0018 0.0013 0.0244
Mycobacterium leprae Conserved hypothetical protein 0.0019 0.0015 0.0029
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0003 0.0457
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Brugia malayi Cytochrome P450 family protein 0.0019 0.0015 0.0143
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0013 0.0127
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0041 0.0051 0.0408
Loa Loa (eye worm) hypothetical protein 0.0052 0.0069 0.0669
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0053 0.0516
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0006 0.0136
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0026 0.0215
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0011 0.0001 0.0002
Plasmodium falciparum heat shock protein 90, putative 0.0029 0.0031 0.1022
Loa Loa (eye worm) ctsf protein 0.0018 0.0013 0.0127
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0035 0.004 0.0969
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0051 0.0413
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0009 0.0035
Echinococcus multilocularis heat shock protein 0.005 0.0066 0.0528
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0013 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0136
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0389
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0051 0.0413
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0023 0.055
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0013 0.0316
Mycobacterium ulcerans heat shock protein 90 0.0047 0.006 0.006
Entamoeba histolytica hypothetical protein 0.004 0.0048 0.7286
Brugia malayi isocitrate dehydrogenase 0.0017 0.0011 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0009 0.0036
Entamoeba histolytica hypothetical protein 0.004 0.0048 0.7286
Echinococcus multilocularis zinc finger protein 0.0023 0.0021 0.0166
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0006 0.0054
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0003 0.0029
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0019 0.0015 0.0014
Loa Loa (eye worm) heat shock protein 75 0.0033 0.0038 0.0368
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Trypanosoma brucei protein kinase, putative 0.0056 0.0075 0.0685
Brugia malayi PHD-finger family protein 0.0014 0.0006 0.0062
Schistosoma mansoni jumonji domain containing protein 0.0083 0.012 0.048
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0013 0.0244
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Trichomonas vaginalis ABC transporter, putative 0.0035 0.004 0.0969
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0035 0.0288
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0019 0.0015 0.0014
Onchocerca volvulus 0.0018 0.0013 0.0244
Echinococcus granulosus death domain containing protein 0.0016 0.0009 0.0071
Trichomonas vaginalis ABC transporter, putative 0.0035 0.004 0.0969
Loa Loa (eye worm) heat shock protein 90 0.005 0.0066 0.0638
Echinococcus granulosus tyrosine protein kinase Src64B 0.0041 0.0051 0.0413
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0006 0.0054
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0383
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0052
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0035 0.004 0.0324
Schistosoma mansoni polycystin 1-related 0.0022 0.0018 0.0074
Echinococcus multilocularis transfer RNA-Lys 0.004 0.0048 0.0384
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0038 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0136
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0035 0.004 0.1327
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.0087
Trichomonas vaginalis heat shock protein, putative 0.0047 0.006 0.1468
Echinococcus multilocularis endoplasmin 0.0047 0.006 0.0487
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0019 0.0015 0.0014
Loa Loa (eye worm) ABC transporter 0.0011 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0179 0.0278 0.2705
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0018 0.0149
Entamoeba histolytica heat shock protein 90, putative 0.005 0.0066 1
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0021 0.0207
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0035 0.004 0.032
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0127
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0043 0.0054 0.0436
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0038 0.1257
Brugia malayi Hsp90 protein 0.0033 0.0038 0.0368
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0011 0.0098
Schistosoma mansoni hypothetical protein 0.0017 0.001 0.0042
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0041 0.0051 0.0413
Trypanosoma brucei heat shock protein 84, putative 0.0033 0.0038 0.0343
Onchocerca volvulus 0.0022 0.0018 0.0376
Schistosoma mansoni endoplasmin 0.005 0.0066 0.0263
Entamoeba histolytica ATP-binding cassette protein, putative 0.0011 0.0001 0.0095
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0029
Echinococcus multilocularis RUN 0.0022 0.0018 0.0144
Brugia malayi PAS domain containing protein 0.0053 0.0071 0.0688
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0051 0.0408
Schistosoma mansoni hypothetical protein 0.0186 0.0289 0.1158
Entamoeba histolytica P-glycoprotein 6, putative 0.0011 0.0001 0.0095
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0127
Echinococcus granulosus cpg binding protein 0.0035 0.0041 0.0334
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0019 0.0015 0.0014
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0009 0.0085
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0047 0.006 0.006
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0014 0.0006 0.0045
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0001 0.0008
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0006 0.0054
Onchocerca volvulus Alhambra homolog 0.0032 0.0035 0.0793
Brugia malayi Cytochrome P450 family protein 0.0029 0.0031 0.0298
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0031 0.0298
Echinococcus multilocularis ATP binding cassette sub family B 0.0034 0.0039 0.0314
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0006 0.0136
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0026 0.021
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0069 0.0558
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0179
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0054
Brugia malayi multidrug resistance related protein 1 0.0011 0.0001 0.0006
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Loa Loa (eye worm) TK protein kinase 0.0037 0.0044 0.043
Trichomonas vaginalis ABC transporter, putative 0.0035 0.004 0.0969
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0019 0.0015 0.0014
Brugia malayi ABC transporter family protein 0.0035 0.004 0.0389
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.0075 0.0604
Schistosoma mansoni hypothetical protein 0.0023 0.002 0.008
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0031 0.0276
Entamoeba histolytica multidrug resistance protein, putative 0.0011 0.0001 0.0095
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0098 0.0899
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0019 0.0015 0.0014
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0033 0.0038 0.0307
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Onchocerca volvulus 0.0035 0.004 0.0902
Echinococcus granulosus arachidonate 5 lipoxygenase 0.013 0.0196 0.1593
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0098 0.0899
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0023 0.0184
Echinococcus granulosus heat shock protein 90 0.005 0.0066 0.0533
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0006 0.0046
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0019 0.0015 0.0014
Trichomonas vaginalis abcb9, putative 0.0035 0.004 0.0969
Giardia lamblia ABC transporter, putative 0.0011 0.0001 0.0083
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0075 0.1816
Echinococcus granulosus ATP binding cassette sub family B 0.0011 0.0001 0.0005
Entamoeba histolytica heat shock protein 90, putative 0.005 0.0066 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.0044 0.0354
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0011 0.0098
Brugia malayi jmjC domain containing protein 0.0105 0.0155 0.1513
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0069 0.0553
Plasmodium vivax heat shock protein 86, putative 0.005 0.0066 0.2194
Brugia malayi Doublecortin family protein 0.0022 0.0018 0.0179
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0035 0.004 0.0969
Echinococcus granulosus zinc finger protein 0.0023 0.0021 0.0171
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0019 0.0015 0.0014
Loa Loa (eye worm) multidrug resistance protein 3 0.0035 0.004 0.0389
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0019 0.0015 0.0014
Plasmodium falciparum phd finger protein, putative 0.0032 0.0035 0.1176
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0011 0.036
Trypanosoma cruzi heat shock protein 90, putative 0.0021 0.0017 0.0155
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0041 0.0051 0.0408
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0014 0.011
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0041 0.0051 0.0408
Echinococcus multilocularis multidrug resistance protein 1 0.0035 0.004 0.032
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0047 0.006 0.0122
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.0037 0.0299
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0015 0.0059
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0013 0.0114
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0035 0.004 0.0363
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0011 0.011
Echinococcus granulosus ATP binding cassette sub family B 0.0011 0.0001 0.0005
Onchocerca volvulus 0.003 0.0031 0.0696
Echinococcus multilocularis geminin 0.0186 0.0289 0.2346
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Trichomonas vaginalis ABC transporter, putative 0.0035 0.004 0.0969
Brugia malayi ABC transporter transmembrane region family protein 0.0011 0.0001 0.0006
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0019 0.0015 0.0014
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0011 0.0098
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0019 0.0015 0.0014
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0094 0.0761
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0075 0.0685
Brugia malayi ABC transporter family protein 0.0011 0.0001 0.0006
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0006 0.0136
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Onchocerca volvulus 0.0018 0.0013 0.0244
Trichomonas vaginalis abcb9, putative 0.0035 0.004 0.0969
Schistosoma mansoni multidrug resistance protein 0.0011 0.0001 0.0002
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0062
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0035 0.004 0.0969
Mycobacterium ulcerans putative regulatory protein 0.004 0.0048 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0029
Onchocerca volvulus 0.0032 0.0035 0.0773
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0092 0.0892
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0019 0.0015 0.0014
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0009 0.0071
Leishmania major cathepsin L-like protease 0.007 0.0098 0.0899
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0035 0.004 0.0324
Trypanosoma brucei Heat shock protein 83, putative 0.005 0.0066 0.0599
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0013 0.1983
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0019 0.0015 0.0014
Plasmodium vivax multidrug resistance protein 1, putative 0.0035 0.004 0.1327
Loa Loa (eye worm) hypothetical protein 0.0078 0.0111 0.1077
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0023 0.0184
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0003 0.0012
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0019 0.0015 0.0014
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0013 0.0052
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0006 0.0136
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0066 0.0599
Entamoeba histolytica P-glycoprotein-2 0.0035 0.004 0.6088
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0019 0.0015 0.0014
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0669 0.1084 0.1084
Schistosoma mansoni netrin receptor unc5 0.0016 0.0009 0.0035
Brugia malayi PHD-finger family protein 0.0032 0.0035 0.0345
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0033 0.0038 0.0302
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0066 0.0599
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0019 0.0015 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0018 0.0179
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0019 0.0015 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0013 0.0114
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0048 0.0388
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0035 0.0283
Entamoeba histolytica P-glyco protein 6, putative 0.0035 0.004 0.6088
Echinococcus granulosus intermediate filament protein 0.003 0.0031 0.0256
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0011 0.0001 0.0006
Trypanosoma brucei ISWI complex protein 0.0017 0.001 0.009
Schistosoma mansoni multidrug resistance protein 0.0035 0.004 0.016
Brugia malayi Cytochrome P450 family protein 0.0029 0.0031 0.0298
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0014 0.0006 0.005
Echinococcus multilocularis cpg binding protein 0.0035 0.0041 0.0329
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0035 0.0345
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0053 0.043
Brugia malayi Uncoordinated protein 44 0.0016 0.0009 0.0085
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0001 0.0006
Brugia malayi Bromodomain containing protein 0.0035 0.004 0.0387
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0013 0.0052
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.0155 0.1258
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0035 0.0337
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0011 0.036
Onchocerca volvulus 0.0261 0.0412 1
Brugia malayi P-glycoprotein-like protein 0.0011 0.0001 0.0006
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0035 0.004 0.032
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Brugia malayi Protein kinase domain containing protein 0.0016 0.001 0.0093
Schistosoma mansoni hypothetical protein 0.0019 0.0015 0.0059
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0041 0.0051 0.0408
Loa Loa (eye worm) endoplasmin 0.005 0.0066 0.0638
Loa Loa (eye worm) SRC-1 0.0041 0.0051 0.0495
Echinococcus multilocularis Ankyrin 0.0016 0.0009 0.0068
Loa Loa (eye worm) fibroinase 0.0018 0.0013 0.0127
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0011 0.0011
Trichomonas vaginalis heat shock protein, putative 0.0029 0.0031 0.0749
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0031 0.003
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0011 0.0098
Plasmodium vivax heat shock protein 90, putative 0.0033 0.0038 0.1255
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0035 0.1176
Brugia malayi Cathepsin L-like precursor 0.0012 0.0003 0.0029
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0031 0.0298
Echinococcus granulosus multidrug resistance protein 1 0.0035 0.004 0.0324
Entamoeba histolytica P-glycoprotein-2, putative 0.0035 0.004 0.6088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0013 0.0418
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0003 0.0073
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0051 0.0408
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0011 0.0087
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0047 0.0373
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0013 0.0316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0052
Leishmania major cytochrome p450-like protein 0.0029 0.0031 0.0276
Loa Loa (eye worm) ABC transporter 0.0011 0.0001 0.0006
Schistosoma mansoni lamin 0.003 0.0031 0.0126
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0009 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0087
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0026 0.0106
Leishmania major cathepsin L-like protease 0.007 0.0098 0.0899
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.0075 0.0685
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.0075 0.0608
Giardia lamblia Heat shock protein HSP 90-alpha 0.005 0.0066 0.876
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0015 0.012
Mycobacterium leprae Possible regulatory protein 0.0014 0.0006 0.001
Onchocerca volvulus 0.004 0.0048 0.1095
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0019 0.0015 0.0014
Schistosoma mansoni heat shock protein 0.0033 0.0038 0.0151
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0116 0.0942
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0127
Brugia malayi hypoxia-induced factor 1 0.0165 0.0255 0.2482
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0018 0.06
Echinococcus granulosus cathepsin l1 0.0012 0.0003 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0029
Echinococcus granulosus RUN 0.0022 0.0018 0.0149
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0013 0.0106
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Echinococcus granulosus multidrug resistance associated protein 1 0.0011 0.0001 0.0005
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0018 0.0144
Loa Loa (eye worm) hypothetical protein 0.0635 0.1027 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.0044 0.0354
Giardia lamblia Heat shock protein HSP 90-alpha 0.0043 0.0054 0.7161
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0035 0.1176
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0048 0.0191
Entamoeba histolytica P-glycoprotein 5, putative 0.0035 0.004 0.6088
Entamoeba histolytica P-glycoprotein-5 0.0035 0.004 0.6088
Echinococcus multilocularis 0.0019 0.0015 0.0115
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0018 0.0144
Onchocerca volvulus 0.0014 0.0006 0.0063
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0075 0.1816
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.3003 0.4923 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Leishmania major protein kinase, putative 0.0014 0.0006 0.0054
Loa Loa (eye worm) intermediate filament protein 0.003 0.0031 0.0307
Schistosoma mansoni endoplasmin 0.005 0.0066 0.0263
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Entamoeba histolytica protein kinase, putative 0.0033 0.0037 0.5697
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0035 0.004 0.032
Echinococcus granulosus Ankyrin 0.0016 0.0009 0.0073
Onchocerca volvulus 0.003 0.0031 0.0696
Loa Loa (eye worm) TK protein kinase 0.0033 0.0037 0.0364
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.044 0.1762
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0019 0.0015 0.0014
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0035 0.004 0.0324
Brugia malayi cytochrome P450 0.0019 0.0015 0.0143
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0114
Echinococcus multilocularis dnaJ subfamily B 0.045 0.0722 0.5868
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0035 0.004 1
Schistosoma mansoni bromodomain containing protein 0.0071 0.01 0.0401
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.0075 1
Brugia malayi Bromodomain containing protein 0.0084 0.0121 0.1181
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Schistosoma mansoni hypothetical protein 0.004 0.0048 0.0191
Brugia malayi hypothetical protein 0.0011 0.0001 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Brugia malayi multidrug resistance protein 3 0.0035 0.004 0.0389
Plasmodium falciparum heat shock protein 90 0.005 0.0066 0.2194
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0019 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0032 0.0035 0.0345
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Giardia lamblia Grp94/Hsp90 0.0047 0.006 0.808
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0053 0.0212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0053 0.0212
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0035 0.004 0.0969
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0013 0.0127
Echinococcus granulosus multidrug resistance protein 1 0.0035 0.004 0.0324
Schistosoma mansoni lipoxygenase 0.0091 0.0132 0.0528
Brugia malayi hypothetical protein 0.004 0.0048 0.0465
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0042 0.0339
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0011 0.036
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0011 0.0001 0.0006
Plasmodium vivax endoplasmin, putative 0.005 0.0066 0.2194
Brugia malayi Pre-SET motif family protein 0.0033 0.0038 0.0368
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0031 0.0276
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.0155 0.1263
Echinococcus granulosus dnaJ subfamily B 0.045 0.0722 0.587
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0669 0.1084 0.1084
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.0075 0.0685
Loa Loa (eye worm) hypothetical protein 0.0055 0.0073 0.0712
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0006 0.0046
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0019 0.0015 0.0014
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0056 0.0451
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.0092
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.0075 0.0685
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0015 0.0476
Plasmodium vivax heat shock protein, putative 0.0191 0.0297 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0011 0.0045
Entamoeba histolytica P-glycoprotein-2 0.0035 0.004 0.6088
Trypanosoma brucei heat shock protein, putative 0.005 0.0066 0.0599
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0035 0.004 0.0389
Schistosoma mansoni smdr2 0.0035 0.004 0.016
Schistosoma mansoni intermediate filament proteins 0.003 0.0031 0.0126
Echinococcus granulosus tyrosine kinase 0.0037 0.0044 0.0359
Brugia malayi PHD-finger family protein 0.0029 0.0031 0.0299
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Brugia malayi Bromodomain containing protein 0.0042 0.0052 0.0506
Brugia malayi hypothetical protein 0.0022 0.0018 0.0179
Brugia malayi cathepsin L-like precursor 0.0012 0.0003 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0075 0.1816
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0019 0.0015 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.6089 1 1
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0023 0.0179
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0006 0.004
Echinococcus granulosus cathepsin l1 0.0018 0.0013 0.0106
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Echinococcus multilocularis musashi 0.003 0.0031 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0035 0.004 0.0969
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0048 0.0383
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0669 0.1084 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0013 0.0418
Schistosoma mansoni multidrug resistance protein 0.0035 0.004 0.016
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0014 0.0006 0.0046
Leishmania major protein kinase, putative 0.0014 0.0006 0.0054
Echinococcus granulosus geminin 0.0186 0.0289 0.235
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0013 0.0316
Entamoeba histolytica hypothetical protein 0.004 0.0048 0.7286
Trypanosoma cruzi heat shock protein 90, putative 0.005 0.0066 0.0599
Giardia lamblia Multidrug resistance-associated protein 1 0.0011 0.0001 0.0083
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0019 0.0015 0.0014
Echinococcus granulosus tyrosine protein kinase Fyn 0.0041 0.0051 0.0413
Onchocerca volvulus 0.0018 0.0013 0.0244
Echinococcus granulosus peregrin 0.0035 0.004 0.0323
Trichomonas vaginalis taga, putative 0.0035 0.004 0.0969
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0013 0.1983
Loa Loa (eye worm) ABC transporter 0.0011 0.0001 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Leishmania major cathepsin L-like protease 0.0018 0.0013 0.0114
Brugia malayi small heat shock protein 0.0635 0.1027 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0006 0.0136
Trypanosoma cruzi Heat shock protein 83, putative 0.005 0.0066 0.0599
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.002 0.0195
Brugia malayi Cathepsin L-like precursor 0.0012 0.0003 0.0029
Brugia malayi protein-tyrosine kinase 0.0037 0.0044 0.043
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0019 0.0015 0.0014
Echinococcus granulosus lamin dm0 0.003 0.0031 0.0256
Schistosoma mansoni zinc finger protein 0.0017 0.001 0.0042
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0035 0.004 0.0969
Loa Loa (eye worm) cytochrome P450 0.0019 0.0015 0.0143
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.0075 0.0729
Schistosoma mansoni microtubule-associated protein tau 0.0758 0.123 0.4929
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0019 0.0015 0.0014
Echinococcus multilocularis cysteine protease 0.0018 0.0013 0.0101
Loa Loa (eye worm) hypothetical protein 0.0049 0.0063 0.0611
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0013 0.0101
Leishmania major p-glycoprotein 0.0035 0.004 0.0363
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0018 0.0144
Schistosoma mansoni smdr1 0.0011 0.0001 0.0002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0031 0.0307
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0031 0.0298
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0013 0.0101
Trichomonas vaginalis heat shock protein, putative 0.0047 0.006 0.1468
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0011 0.0098
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0019 0.0015 0.0014
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0047 0.006 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Trypanosoma cruzi heat shock protein 85, putative 0.005 0.0066 0.0599
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0098 0.0899
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0116 0.0937
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.0075 0.0604
Echinococcus multilocularis lamin 0.003 0.0031 0.0251
Echinococcus granulosus tyrosine protein kinase Src42A 0.0041 0.0051 0.0413
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0038 0.0152
Schistosoma mansoni heat shock protein 0.005 0.0066 0.0263
Schistosoma mansoni cpg binding protein 0.0035 0.0041 0.0165
Schistosoma mansoni heat shock protein 0.005 0.0066 0.0263
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0389
Trypanosoma cruzi heat shock protein 85, putative 0.0043 0.0054 0.0489
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0015 0.013
Echinococcus granulosus multidrug resistance associated protein 7 0.0011 0.0001 0.0005
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.0075 0.0608
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0669 0.1084 1
Trypanosoma cruzi heat shock protein, putative 0.0033 0.0038 0.0343
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.0075 0.0685
Giardia lamblia PHD finger protein 15 0.0032 0.0035 0.4735
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0035 0.004 0.0039
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.0075 0.0685
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.0075 0.2507
Toxoplasma gondii Hsp90 domain-containing protein 0.0191 0.0297 1
Entamoeba histolytica cysteine protease, putative 0.0018 0.0013 0.1983
Trichomonas vaginalis heat shock protein, putative 0.005 0.0066 0.1591
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0006 0.0054
Entamoeba histolytica ATP-binding cassette protein, putative 0.0011 0.0001 0.0095
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0035 0.004 0.1327
Toxoplasma gondii heat shock protein 90, putative 0.005 0.0066 0.2194
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.0037 0.0304
Entamoeba histolytica ATP-binding cassette protein, putative 0.0011 0.0001 0.0095
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.0075 0.0685
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0056 0.0456
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0011 0.0087
Trypanosoma brucei heat shock protein 90, putative 0.005 0.0066 0.0599
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0035 0.004 0.0969
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0006 0.0136
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Trichomonas vaginalis heat shock protein, putative 0.0043 0.0054 0.1301
Brugia malayi Cathepsin L-like precursor 0.0018 0.0013 0.0127
Loa Loa (eye worm) hypothetical protein 0.0042 0.0052 0.0507
Treponema pallidum heat shock protein 90 0.0047 0.006 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0044 0.0354
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0006 0.0136
Trichomonas vaginalis endoplasmin, putative 0.0037 0.0043 0.104
Echinococcus granulosus multidrug resistance protein 1 0.0035 0.004 0.0324
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0061
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0035 0.004 0.0324
Schistosoma mansoni hypothetical protein 0.0186 0.0289 0.1158
Schistosoma mansoni hypothetical protein 0.0057 0.0076 0.0305
Brugia malayi ABC transporter family protein 0.0011 0.0001 0.0006
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0013 0.0101
Schistosoma mansoni zinc finger protein 0.0023 0.0021 0.0084
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0006 0.0136
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0006 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0013 0.0316
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0003 0.0084
Entamoeba histolytica hypothetical protein 0.0011 0.0001 0.0095
Schistosoma mansoni hypothetical protein 0.045 0.0722 0.2893
Plasmodium vivax vivapain-2 0.0018 0.0013 0.0418
Onchocerca volvulus 0.0018 0.0013 0.0244
Loa Loa (eye worm) hypothetical protein 0.0018 0.0013 0.0127
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0048 0.0388
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.0044 0.0359
Leishmania major heat shock protein 83-1 0.005 0.0066 0.0599
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0009 0.014
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0019 0.0015 0.0014
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0041 0.0051 0.0413
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0033 0.0038 0.0849
Echinococcus granulosus single minded 2 0.004 0.0048 0.0389
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0047 0.006 0.0552
Schistosoma mansoni lamin 0.003 0.0031 0.0126
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.0075 0.1816
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0018 0.0149
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0019 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.003 0.0031 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Brugia malayi hypothetical protein 0.0179 0.0278 0.2705
Leishmania major hypothetical protein, conserved 0.0017 0.001 0.009
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0035 0.004 0.0969
Trypanosoma cruzi ISWI complex protein 0.0017 0.001 0.009
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0015 0.0143
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0006
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0014 0.0054
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0006 0.0136
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0018 0.0179
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0013 0.0418
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0003 0.0084
Schistosoma mansoni cytochrome P450 0.0019 0.0015 0.0059
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.013 0.0196 0.1588
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0006 0.0054
Schistosoma mansoni rab6-interacting 0.0022 0.0018 0.0074
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0009 0.0086
Echinococcus granulosus heat shock protein 0.005 0.0066 0.0533
Plasmodium vivax SET domain protein, putative 0.0033 0.0038 0.1257
Schistosoma mansoni hypothetical protein 0.0032 0.0035 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0098 0.0899
Brugia malayi Endoplasmin precursor 0.005 0.0066 0.0638
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0001 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0019 0.0015 0.0014
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0048 0.0383
Echinococcus granulosus microtubule associated protein 2 0.0758 0.123 1
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0015 0.0143
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0011 0.036
Echinococcus multilocularis microtubule associated protein 2 0.0758 0.123 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0035 0.0142
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0009 0.0066
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0035 0.0282
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0011 0.011
Plasmodium falciparum multidrug resistance protein 1 0.0035 0.004 0.1327
Plasmodium vivax vivapain-2 0.0018 0.0013 0.0418
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0019 0.0015 0.0014
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0035 0.004 0.0969
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0069 0.0275
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0098 0.0899
Echinococcus multilocularis cysteine protease 0.0018 0.0013 0.0101
Schistosoma mansoni cpg binding protein 0.0032 0.0035 0.0139
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0031 0.0276
Echinococcus granulosus heat shock protein 90 0.0043 0.0054 0.0436
Plasmodium falciparum heat shock protein 90, putative 0.0191 0.0297 1
Giardia lamblia MRP-like ABC transporter 0.0011 0.0001 0.0083
Trypanosoma cruzi ISWI complex protein 0.0017 0.001 0.009
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.036 0.3507
Echinococcus multilocularis multidrug resistance protein 1 0.0035 0.004 0.032
Brugia malayi heat shock protein 90 0.005 0.0066 0.0638
Brugia malayi Cytochrome P450 family protein 0.0019 0.0015 0.0143
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0094 0.0756

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 11 uM Compound was tested for the inhibitory activity against HIV-protease ChEMBL. No reference
Ki (binding) = 11 uM Compound was tested for the inhibitory activity against HIV-protease ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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