TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 439.509 | Formula: C26H25N5O2
H donors: 2 H acceptors: 3 LogP: 3.95 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COCCCn1c(NC(=O)c2ccc(cc2)C#N)nc2c1ccc(c2)CNc1ccccc1
InChi: 1S/C26H25N5O2/c1-33-15-5-14-31-24-13-10-20(18-28-22-6-3-2-4-7-22)16-23(24)29-26(31)30-25(32)21-11-8-19(17-27)9-12-21/h2-4,6-13,16,28H,5,14-15,18H2,1H3,(H,29,30,32)
InChiKey: MQOXVHSANORTIN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	IL2-inducible T-cell kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K07370 Bruton agammaglobulinemia tyrosine kinase, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129320	All targets in OG5_129320
Schistosoma japonicum	Tyrosine-protein kinase BTK, putative	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus multilocularis	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320
Echinococcus granulosus	tyrosine protein kinase Btk29A	Get druggable targets OG5_129320	All targets in OG5_129320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0057	0.0057
Schistosoma mansoni	thyroid hormone receptor	0.0077	0.0297	0.1008
Echinococcus multilocularis	nuclear receptor nhr 48	0.0037	0.013	0.0184
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0061	0.0077
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0138	0.0189
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0013	0.0034	0.0022
Brugia malayi	nuclear hormone receptor family member odr-7	0.0037	0.013	0.013
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0041	0.0148	0.0502
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.0024	0.0077	0.0077
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0077	0.0297	0.1008
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	patched family protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0077	0.0297	0.0297
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0167	0.0662	0.2246
Onchocerca volvulus	Huntingtin homolog	0.0135	0.053	0.0523
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0077	0.0297	0.1006
Schistosoma mansoni	hypothetical protein	0.0019	0.0057	0.0192
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0127	0.0117
Loa Loa (eye worm)	pyruvate kinase	0.0016	0.0048	0.0048
Schistosoma mansoni	adapter molecule crk	0.0006	0.0005	0.0018
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0013	0.0034	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0297	0.0297
Echinococcus granulosus	NCK adaptor protein	0.0006	0.0005	0.0015
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1721	0.6996	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0088	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Brugia malayi	Pax transcription activation domain interacting protein	0.0011	0.0026	0.0026
Onchocerca volvulus		0.0017	0.0051	0.0043
Schistosoma mansoni	bromodomain containing protein	0.0005	0.0001	0.0003
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0008	0.0012	0.0006
Treponema pallidum	hypothetical protein	0.0013	0.0034	0.0013
Loa Loa (eye worm)	hypothetical protein	0.002	0.0061	0.0061
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0007	0.0009	0.0011
Echinococcus multilocularis	c src tyrosine kinase	0.0007	0.0009	0.0011
Loa Loa (eye worm)	hypothetical protein	0.002	0.0061	0.0061
Schistosoma mansoni	cpg binding protein	0.0031	0.0109	0.037
Trichomonas vaginalis	ocrl type II inositol 5-phosphatase, putative	0.0013	0.0034	0.0024
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.2457	1	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.013	0.013
Brugia malayi	Niemann-Pick C1 protein precursor	0.011	0.0428	0.0428
Brugia malayi	protein C24B5.3	0.0007	0.0008	0.0008
Echinococcus multilocularis	tar DNA binding protein	0.0055	0.0207	0.0295
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0013	0.0034	0.0034
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0138	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0037	0.013	0.013
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0059	0.022	0.022
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.013	0.0439
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0026	0.0016
Plasmodium vivax	hypothetical protein, conserved	0.0013	0.0034	0.0895
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Brugia malayi	RNA recognition motif domain containing protein	0.0055	0.0207	0.0207
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0013	0.0034	0.0071
Echinococcus multilocularis	pyruvate kinase	0.0078	0.03	0.0427
Plasmodium falciparum	carbon catabolite repressor protein 4, putative	0.0013	0.0034	0.0895
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0077	0.0297	0.0423
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0021	0.0067
Echinococcus multilocularis	Niemann Pick C1 protein	0.011	0.0428	0.061
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0034	0.0034
Echinococcus multilocularis	pyruvate kinase	0.004	0.0144	0.0205
Leishmania major	pyruvate kinase	0.0078	0.03	0.0939
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0012	0.0012
Brugia malayi	hypothetical protein	0.0041	0.0148	0.0148
Trypanosoma cruzi	FHA domain containing protein, putative	0.0011	0.0026	0.0043
Trypanosoma brucei	Inositol phosphosphingolipids phospholipase C	0.0013	0.0034	0.0071
Onchocerca volvulus	Protein ultraspiracle homolog	0.0077	0.0297	0.0289
Brugia malayi	Patched related family protein 10	0.0007	0.0008	0.0008
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0057	0.0071
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0059	0.022	0.022
Entamoeba histolytica	sphingomyelinase C precursor, putative	0.0013	0.0034	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0059	0.022	0.022
Echinococcus granulosus	FTZ F1 alpha	0.0077	0.0297	0.1006
Schistosoma mansoni	retinoic acid receptor RXR	0.0077	0.0297	0.1008
Onchocerca volvulus		0.0017	0.0051	0.0043
Brugia malayi	hypothetical protein	0.0011	0.0026	0.0026
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0077	0.0297	0.0297
Echinococcus multilocularis	protein patched	0.0047	0.0173	0.0246
Echinococcus multilocularis	expressed conserved protein	0.0103	0.0401	0.0571
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0077	0.0297	0.0297
Schistosoma mansoni	nocturnin	0.0013	0.0034	0.0116
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0037	0.013	0.0184
Brugia malayi	nuclear hormone receptor	0.0077	0.0297	0.0297
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0008	0.0012	0.0154
Echinococcus granulosus	mitogen activated protein kinase 3	0.0056	0.0208	0.0704
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0077	0.0297	0.0289
Schistosoma mansoni	hypothetical protein	0.0045	0.0166	0.0563
Brugia malayi	nuclear receptor NHR-88	0.0077	0.0297	0.0297
Giardia lamblia	Pyruvate kinase	0.004	0.0144	0.0119
Entamoeba histolytica	transcription factor BTF3, putative	0.0072	0.0273	0.0261
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0138	0.0189
Schistosoma mansoni	hypothetical protein	0.0392	0.1578	0.536
Echinococcus granulosus	Niemann Pick C1 protein	0.011	0.0428	0.145
Entamoeba histolytica	hypothetical protein	0.0011	0.0026	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0026
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Giardia lamblia	Fructose-bisphosphate aldolase	0.1666	0.6774	0.6766
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.011	0.0428	0.0416
Entamoeba histolytica	hypothetical protein	0.0116	0.0452	0.044
Schistosoma mansoni	tyrosine kinase	0.0007	0.0009	0.003
Schistosoma mansoni	hypothetical protein	0.0045	0.0166	0.0563
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0007	0.0009	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0138	0.0138
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0008	0.0012	0.0006
Entamoeba histolytica	hypothetical protein	0.0116	0.0452	0.044
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0203	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0138	0.0138
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.2457	1	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0037	0.0133	0.4287
Entamoeba histolytica	acetyltransferase, GNAT family	0.0034	0.012	0.0108
Plasmodium vivax	pyruvate kinase, putative	0.0078	0.03	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0138	0.0138
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0077	0.0297	0.0423
Trichomonas vaginalis	ap endonuclease, putative	0.0065	0.0244	0.0235
Plasmodium falciparum	pyruvate kinase 2	0.004	0.0144	0.468
Echinococcus granulosus	lamin dm0	0.0029	0.0101	0.0341
Trypanosoma brucei	transcription factor BTF3, putative	0.0072	0.0273	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0065	0.0244	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0297	0.0297
Trypanosoma cruzi	Inositol phosphosphingolipids phospholipase C	0.0013	0.0034	0.0071
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0026	0.0016
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0007	0.0009	0.0011
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0013	0.0034	0.0071
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0008	0.0012	0.0154
Echinococcus multilocularis	replication factor c subunit 1	0.0011	0.0026	0.0035
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.0101	0.0101
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0037	0.0133	0.4287
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0045	0.0045
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0207	0.0703
Brugia malayi	pyruvate kinase	0.0016	0.0048	0.0048
Trypanosoma cruzi	hypothetical protein, conserved	0.0758	0.3069	1
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0008	0.0012	0.0017
Loa Loa (eye worm)	glutaminase	0.0239	0.0956	0.0956
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0013	0.0017
Schistosoma mansoni	DNA ligase IV	0.0011	0.0026	0.0087
Brugia malayi	beta-lactamase	0.0039	0.0138	0.0138
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0057	0.0057
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0013	0.0034	0.0034
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0013	0.0034	0.0071
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0077	0.0297	0.0297
Onchocerca volvulus		0.0026	0.0088	0.0081
Brugia malayi	tailless protein	0.0037	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Trichomonas vaginalis	replication factor C large subunit, putative	0.0011	0.0026	0.0016
Brugia malayi	hypothetical protein	0.0116	0.0452	0.0452
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0814	0.3299	0.3291
Schistosoma mansoni	aldehyde dehydrogenase	0.0053	0.0198	0.0671
Trypanosoma cruzi	endonuclease/exonuclease/phosphatase, putative	0.0013	0.0034	0.0071
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0053	0.0198	0.0185
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0088	0.0088
Schistosoma mansoni	ap endonuclease	0.0065	0.0244	0.083
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0008	0.0012	0.0006
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0088	0.0088
Echinococcus granulosus	GPCR family 2	0.0019	0.0057	0.0189
Echinococcus granulosus	growth factor receptor bound protein 2	0.0006	0.0005	0.0015
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.1666	0.6774	0.677
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0013	0.0034	0.0022
Plasmodium vivax	endonuclease/exonuclease/phosphatase domain containing protein	0.0013	0.0034	0.0895
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0012	0.0012
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0011	0.0026	0.0013
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0037	0.013	0.0184
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0061	0.1828
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0041	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0039	0.0039
Schistosoma mansoni	tyrosine kinase	0.0007	0.0009	0.003
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0008	0.0012	0.0006
Echinococcus multilocularis	inositol polyphosphate 5 phosphatase OCRL 1	0.0013	0.0034	0.0047
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0138	0.0189
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0138	0.0467
Brugia malayi	acetyltransferase, GNAT family protein	0.0127	0.0498	0.0498
Echinococcus multilocularis	expressed protein	0.0036	0.0127	0.018
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1666	0.6774	0.6771
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0078	0.03	0.03
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0053	0.0198	0.0281
Loa Loa (eye worm)	CCR4-NOT transcription complex subunit 6 family protein	0.0013	0.0034	0.0034
Entamoeba histolytica	endonuclease/exonuclease/phosphatase domain containing protein	0.0013	0.0034	0.0022
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1666	0.6774	0.6771
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0077	0.0297	0.0423
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0138	0.0126
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0088	0.0076
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0138	0.0189
Echinococcus granulosus	Niemann Pick C1 protein	0.0157	0.0619	0.2102
Plasmodium falciparum	pyruvate kinase	0.0078	0.03	1
Echinococcus granulosus	Protein patched homolog 1	0.0047	0.0173	0.0584
Echinococcus multilocularis	Niemann Pick C1 protein	0.0157	0.0619	0.0884
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0138	0.0189
Loa Loa (eye worm)	pyruvate kinase	0.0078	0.03	0.03
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0144	0.0144
Onchocerca volvulus		0.0008	0.0012	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0037	0.013	0.013
Trypanosoma brucei	RNA editing exonuclease 2	0.0013	0.0034	0.0071
Trypanosoma brucei	inositol/phosphatidylinositol phosphatase, putative	0.0013	0.0034	0.0071
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0758	0.3069	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.013	0.0184
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0013	0.0034	0.0895
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0088	0.0249
Toxoplasma gondii	PPIC-type PPIASE domain-containing protein	0.0011	0.0025	0.0594
Brugia malayi	Variant SH3 domain containing protein	0.0006	0.0005	0.0005
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0007	0.0009	0.0011
Brugia malayi	nuclear receptor NHR-67	0.0037	0.013	0.013
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0013	0.0034	0.0895
Brugia malayi	SRC-1	0.0007	0.0009	0.0009
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.2457	1	1
Brugia malayi	pyruvate kinase, muscle isozyme	0.0016	0.0048	0.0048
Trichomonas vaginalis	rotamase, putative	0.0036	0.0127	0.0117
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.2457	1	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0065	0.0244	0.0759
Echinococcus multilocularis	musashi	0.0029	0.0101	0.0143
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0026	0.0016
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0077	0.0297	0.1006
Onchocerca volvulus	Huntingtin homolog	0.0135	0.053	0.0523
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.013	0.0441
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0013	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0061	0.1828
Loa Loa (eye worm)	patched family protein	0.0007	0.0008	0.0008
Giardia lamblia	Inositol 5-phosphatase 4	0.0013	0.0034	0.0009
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0138	0.0129
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0013	0.0034	0.0895
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0037	0.013	0.0439
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0013	0.0034	0.0034
Schistosoma mansoni	nck2/grb4	0.0006	0.0005	0.0018
Brugia malayi	nuclear receptor RXR	0.0037	0.013	0.013
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0758	0.3069	0.3063
Brugia malayi	Bromodomain containing protein	0.0005	0.0001	0.0001
Echinococcus multilocularis	geminin	0.0392	0.1578	0.2254
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0017	0.0051	0.0072
Echinococcus multilocularis	pyruvate kinase	0.004	0.0144	0.0205
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0088	0.0076
Schistosoma mansoni	ap endonuclease	0.0065	0.0244	0.083
Leishmania major	hypothetical protein, conserved	0.0013	0.0034	0.0071
Echinococcus granulosus	intermediate filament protein	0.0029	0.0101	0.0341
Echinococcus multilocularis	NCK adaptor protein	0.0006	0.0005	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0077	0.0297	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0012	0.0012
Schistosoma mansoni	pyruvate kinase	0.0078	0.03	0.1018
Loa Loa (eye worm)	hypothetical protein	0.0078	0.03	0.03
Toxoplasma gondii	pyruvate kinase PyK1	0.0078	0.03	1
Loa Loa (eye worm)	RNA binding protein	0.0055	0.0207	0.0207
Toxoplasma gondii	aldehyde dehydrogenase	0.0053	0.0198	0.6502
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0011	0.0025	0.0042
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0138	0.047
Echinococcus granulosus	neutral sphingomyelinase	0.0013	0.0034	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0138	0.0138
Onchocerca volvulus		0.0008	0.0012	0.0004
Leishmania major	hypothetical protein, conserved	0.0039	0.0138	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0005
Leishmania major	pantothenate kinase subunit, putative	0.0014	0.0038	0.0085
Loa Loa (eye worm)	patched family protein	0.0007	0.0008	0.0008
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0037	0.013	0.0184
Schistosoma mansoni	growth factor receptor-bound protein	0.0006	0.0005	0.0018
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0138	0.0129
Loa Loa (eye worm)	hypothetical protein	0.002	0.0061	0.0061
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0065	0.0244	0.0342
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0057	0.008
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0053	0.0198	0.0274
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0007	0.0009	0.0027
Brugia malayi	Myosin head containing protein	0.0007	0.0008	0.0008
Brugia malayi	CCR4	0.0013	0.0034	0.0034
Schistosoma mansoni	transcription factor btf3	0.0072	0.0273	0.0928
Giardia lamblia	hypothetical protein	0.0013	0.0034	0.0009
Schistosoma mansoni	hypothetical protein	0.0019	0.0057	0.0192
Loa Loa (eye worm)	doublecortin family protein	0.0017	0.0051	0.0051
Brugia malayi	hypothetical protein	0.0017	0.0051	0.0051
Brugia malayi	Patched related family protein 4	0.0007	0.0008	0.0008
Onchocerca volvulus		0.0011	0.0026	0.0018
Loa Loa (eye worm)	hypothetical protein	0.002	0.0061	0.0061
Echinococcus granulosus	nibrin	0.0011	0.0026	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0138	0.0138
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0138	0.0138
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0013	0.0034	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0173	0.0173
Schistosoma mansoni	pyruvate kinase	0.004	0.0144	0.0491
Plasmodium falciparum	replication factor C subunit 1, putative	0.0011	0.0026	0.0603
Echinococcus granulosus	RUN	0.0017	0.0051	0.0171
Onchocerca volvulus	Pyruvate kinase homolog	0.0078	0.03	0.0292
Brugia malayi	hypothetical protein	0.0007	0.0008	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0077	0.0297	0.0297
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0006	0.0005	0.0006
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0208	0.0198
Echinococcus granulosus	tumor protein p63	0.0376	0.1514	0.5143
Schistosoma mansoni	acetyl-CoA synthetase	0.0008	0.0012	0.0042
Echinococcus granulosus	expressed protein	0.0036	0.0127	0.0429
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1666	0.6774	0.6771
Loa Loa (eye worm)	hypothetical protein	0.002	0.0061	0.0061
Schistosoma mansoni	topbp1	0.0011	0.0026	0.0087
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0207	0.0703
Onchocerca volvulus		0.0029	0.0101	0.0093
Loa Loa (eye worm)	SRC-1	0.0007	0.0009	0.0009
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1666	0.6774	0.6771
Echinococcus multilocularis	pyruvate kinase	0.0078	0.03	0.0427
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0065	0.0244	0.8106
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0138	0.0138
Schistosoma mansoni	nuclear hormone receptor	0.0077	0.0297	0.1008
Echinococcus multilocularis	pyruvate kinase	0.0062	0.0232	0.0331
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.17	0.6912	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0037	0.0133	0.4287
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0013	0.0034	0.0895
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0057	0.0057
Schistosoma mansoni	patched 1	0.0047	0.0173	0.0587
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.013	0.013
Schistosoma mansoni	neutral sphingomyelinase	0.0013	0.0034	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0034	0.0034
Brugia malayi	Patched related family protein 12	0.0007	0.0008	0.0008
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0008	0.0012	0.0006
Loa Loa (eye worm)	glutaminase 2	0.0239	0.0956	0.0956
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0138	0.447
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0013	0.0034	0.0895
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.2457	1	1
Entamoeba histolytica	hypothetical protein	0.0116	0.0452	0.044
Trypanosoma cruzi	RNA-editing complex protein MP100, putative	0.0013	0.0034	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0037	0.013	0.013
Echinococcus granulosus	lamin	0.0029	0.0101	0.0341
Echinococcus granulosus	tar DNA binding protein	0.0055	0.0207	0.07
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0208	0.0198
Echinococcus granulosus	microtubule associated protein 2	0.0727	0.2943	1
Trypanosoma brucei	pyruvate kinase 1	0.0078	0.03	0.0939
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0138	0.0126
Brugia malayi	steroid hormone receptor	0.0077	0.0297	0.0297
Loa Loa (eye worm)	hypothetical protein	0.004	0.0144	0.0144
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0077	0.0297	0.0297
Schistosoma mansoni	synaptojanin	0.0013	0.0034	0.0116
Plasmodium falciparum	LCCL domain-containing protein	0.0017	0.0051	0.1484
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0047	0.0173	0.0173
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0065	0.0244	0.0324
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0056	0.0208	0.0208
Echinococcus multilocularis	dnaJ subfamily B	0.0447	0.1804	0.2577
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0008	0.0012	0.0154
Schistosoma mansoni	lipoxygenase	0.0048	0.0178	0.0604
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0088	0.0076
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0077	0.0297	0.1008
Schistosoma mansoni	hypothetical protein	0.0116	0.0452	0.1536
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0013	0.0034	0.0034
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Echinococcus multilocularis	FTZ F1 alpha	0.0077	0.0297	0.0423
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0035	0.0124	0.0363
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0007	0.0009	0.003
Echinococcus granulosus	pyruvate kinase	0.0078	0.03	0.1015
Trichomonas vaginalis	type II inositol 5-phosphatase, putative	0.0013	0.0034	0.0024
Echinococcus granulosus	expressed conserved protein	0.0103	0.0401	0.1358
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1666	0.6774	0.6771
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.2457	1	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0077	0.0297	0.1006
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0148	0.0148
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0013	0.004
Loa Loa (eye worm)	hypothetical protein	0.0135	0.053	0.053
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0065	0.0244	0.0244
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0013	0.0034	0.0113
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.0208	0.0707
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0008	0.0012	0.0012
Schistosoma mansoni	hypothetical protein	0.0447	0.1804	0.6127
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0116	0.0452	0.1534
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0078	0.03	0.0939
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0057	0.0057
Brugia malayi	photoreceptor-specific nuclear receptor	0.0077	0.0297	0.0297
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0077	0.0297	0.1006
Echinococcus multilocularis	mitogen activated protein kinase	0.0056	0.0208	0.0296
Brugia malayi	hypothetical protein	0.0007	0.0008	0.0008
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0138	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.0001
Schistosoma mansoni	cpg binding protein	0.0033	0.0116	0.0395
Leishmania major	hypothetical protein, conserved	0.0013	0.0034	0.0071
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0814	0.3299	0.4768
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0013	0.0034	0.0071
Brugia malayi	hypothetical protein	0.0007	0.0008	0.0008
Brugia malayi	nuclear receptor RXR	0.0041	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0088	0.0088
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.2457	1	1
Onchocerca volvulus		0.0008	0.0012	0.0004
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0007	0.0009	0.0011
Toxoplasma gondii	exonuclease III APE	0.0065	0.0244	0.8106
Entamoeba histolytica	pyruvate kinase, putative	0.0055	0.0203	0.0191
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0026	0.0043
Schistosoma mansoni	lipoxygenase	0.0017	0.0051	0.0174
Brugia malayi	DKFZp564C0469 protein	0.0011	0.0026	0.0026
Onchocerca volvulus		0.0055	0.0205	0.0198
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0056	0.0208	0.0296
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0088	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0273	0.0263
Loa Loa (eye worm)	patched family protein	0.0007	0.0008	0.0008
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0035	0.0124	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0077	0.0297	0.0297
Schistosoma mansoni	hypothetical protein	0.0013	0.0034	0.0116
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0065	0.0244	1
Schistosoma mansoni	polycystin 1-related	0.0017	0.0051	0.0174
Onchocerca volvulus	Bile acid receptor homolog	0.0077	0.0297	0.0289
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0138	0.047
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0065	0.0244	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0026
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0138	0.0126
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0012	0.0012
Brugia malayi	hypothetical protein	0.0041	0.0148	0.0148
Brugia malayi	MAP kinase sur-1	0.0056	0.0208	0.0208
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0053	0.0198	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Giardia lamblia	Pyruvate kinase	0.0078	0.03	0.0275
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0013	0.0034	0.0034
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1666	0.6774	0.6771
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0099	0.0099
Echinococcus multilocularis	tumor protein p63	0.0376	0.1514	0.2164
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0138	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Echinococcus multilocularis	RUN	0.0017	0.0051	0.0072
Leishmania major	inositol/phosphatidylinositol phosphatase, putative	0.0013	0.0034	0.0071
Schistosoma mansoni	nuclear receptor	0.0037	0.013	0.0441
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0021	0.0021
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.2457	1	1
Schistosoma mansoni	rab6-interacting	0.0017	0.0051	0.0174
Schistosoma mansoni	lamin	0.0029	0.0101	0.0343
Entamoeba histolytica	hypothetical protein	0.0116	0.0452	0.044
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0012	0.0012
Trichomonas vaginalis	sphingomyelinase C 2 precursor, putative	0.0013	0.0034	0.0024
Brugia malayi	hypothetical protein	0.0037	0.013	0.013
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0077	0.0297	0.0297
Trypanosoma cruzi	mitochondrial protein 99, putative	0.0013	0.0034	0.0071
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0077	0.0297	0.1008
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0013	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0297	0.0297
Schistosoma mansoni	nuclear hormone receptor	0.0037	0.013	0.0441
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0048	0.0178	0.0253
Schistosoma mansoni	loxhd1	0.0017	0.0051	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0007	0.0009	0.0027
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0814	0.3299	1
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0013	0.0034	0.0022
Onchocerca volvulus	Pyruvate kinase homolog	0.0078	0.03	0.0292
Entamoeba histolytica	hypothetical protein	0.0072	0.0273	0.0261
Brugia malayi	Variant SH3 domain containing protein	0.0006	0.0005	0.0005
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Schistosoma mansoni	nuclear receptor nhr-48	0.0037	0.013	0.0441
Plasmodium vivax	endonuclease/exonuclease/phosphatase domain containing protein	0.0013	0.0034	0.0895
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0297	0.0297
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0013	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0037	0.013	0.013
Echinococcus granulosus	replication factor c subunit 1	0.0011	0.0026	0.0084
Brugia malayi	beta-lactamase family protein	0.0039	0.0138	0.0138
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0007	0.0009	0.0011
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0026	0.0043
Trypanosoma brucei	DNA-(apurinic or apyrimidinic site) lyase, putative	0.0013	0.0034	0.0071
Schistosoma mansoni	zinc finger protein	0.0037	0.013	0.0441
Brugia malayi	Sex muscle abnormal protein 5	0.0006	0.0005	0.0005
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0078	0.03	0.03
Brugia malayi	hypothetical protein	0.0007	0.0008	0.0008
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0013	0.0043
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0037	0.0133	0.0449
Trypanosoma brucei	inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative	0.0013	0.0034	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0148	0.0148
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0037	0.013	0.0441
Loa Loa (eye worm)	DR-78	0.0037	0.013	0.013
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0011	0.0026	0.0026
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0138	0.0189
Leishmania major	RNA-editing complex protein MP100, putative	0.0013	0.0034	0.0071
Echinococcus granulosus	synaptojanin 1	0.0013	0.0034	0.0113
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0041	0.0148	0.0499
Onchocerca volvulus	Putative neutral sphingomyelinase	0.0013	0.0034	0.0026
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0013	0.0034	0.0024
Plasmodium vivax	pyruvate kinase 2, putative	0.004	0.0144	0.468
Loa Loa (eye worm)	hypothetical protein	0.0037	0.013	0.013
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0065	0.0244	0.8106
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0056	0.0208	0.6858
Plasmodium falciparum	basic transcription factor 3b, putative	0.0072	0.0273	0.9091
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0039	0.0129
Plasmodium falciparum	DNase I-like protein, putative	0.0013	0.0034	0.0895
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0138	0.0189
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0077	0.0297	0.1008
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0138	0.0197
Echinococcus multilocularis	Polycystic kidney disease protein	0.0017	0.0051	0.0072
Onchocerca volvulus		0.0037	0.013	0.0122
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0207	0.0703
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0077	0.0297	0.0297
Brugia malayi	nuclear hormone receptor	0.0037	0.013	0.013
Brugia malayi	PHD-finger family protein	0.0005	0.0001	0.0001
Trypanosoma cruzi	hypothetical protein, conserved	0.0758	0.3069	1
Brugia malayi	topoisomerase	0.0011	0.0026	0.0026
Brugia malayi	intermediate filament protein	0.0029	0.0101	0.0101
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0077	0.0297	0.0423
Schistosoma mansoni	chromosome transmission fidelity factor	0.0011	0.0026	0.0087
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0077	0.0297	0.0297
Brugia malayi	hypothetical protein	0.0011	0.0026	0.0026
Loa Loa (eye worm)	ICD-1 protein	0.0072	0.0273	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0037	0.013	0.013
Echinococcus granulosus	pyruvate kinase	0.004	0.0144	0.0488
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0013	0.0017
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0056	0.0208	0.0639
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0077	0.0297	0.0423
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0035	0.0124	0.0111
Schistosoma mansoni	thyroid hormone receptor	0.0077	0.0297	0.1008
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0037	0.013	0.0439
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0013	0.0034	0.0034
Toxoplasma gondii	ABC1 family protein	0.0039	0.0138	0.447
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0037	0.013	0.013
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0208	0.0198
Onchocerca volvulus		0.0037	0.013	0.0122
Echinococcus multilocularis	lamin dm0	0.0029	0.0101	0.0143
Brugia malayi	RNA binding protein	0.0055	0.0207	0.0207
Brugia malayi	ecdysone receptor	0.0037	0.013	0.013
Trichomonas vaginalis	esterase, putative	0.0039	0.0138	0.0129
Brugia malayi	Patched protein homolog 1	0.0007	0.0008	0.0008
Schistosoma mansoni	cript-related	0.0013	0.0034	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0037	0.0037
Echinococcus multilocularis	sterol regulatory element binding protein	0.0047	0.0173	0.0246
Onchocerca volvulus		0.0008	0.0012	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Schistosoma mansoni	tyrosine kinase	0.0007	0.0009	0.003
Loa Loa (eye worm)	patched family protein	0.0007	0.0008	0.0008
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0056	0.0208	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0051	0.0051
Echinococcus granulosus	pyruvate kinase	0.004	0.0144	0.0488
Plasmodium falciparum	histone acetyltransferase GCN5	0.0034	0.012	0.3853
Trichomonas vaginalis	glutaminase, putative	0.0239	0.0956	0.0947
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0026	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0037	0.013	0.013
Schistosoma mansoni	nuclear receptor	0.0037	0.013	0.0441
Schistosoma mansoni	hypothetical protein	0.0045	0.0166	0.0563
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.0101	0.0101
Loa Loa (eye worm)	hypothetical protein	0.011	0.0428	0.0428
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0173	0.0163
Echinococcus granulosus	sterol regulatory element binding protein	0.0047	0.0173	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0216	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0297	0.0297
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0008	0.0012	0.0012
Echinococcus granulosus	pyruvate kinase	0.0078	0.03	0.1015
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0039	0.0054
Schistosoma mansoni	microtubule-associated protein tau	0.0727	0.2943	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0065	0.0244	0.0759
Loa Loa (eye worm)	pyruvate kinase	0.0078	0.03	0.03
Echinococcus granulosus	inositol polyphosphate 5 phosphatase OCRL 1	0.0013	0.0034	0.0113
Schistosoma mansoni	transcription factor LCR-F1	0.0116	0.0452	0.1536
Schistosoma mansoni	carbon catabolite repressor protein	0.0013	0.0034	0.0116
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0055	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0101	0.0101
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0008	0.0012	0.0039
Schistosoma mansoni	synaptojanin	0.0013	0.0034	0.0116
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0077	0.0297	0.0297
Brugia malayi	orphan nuclear receptor NR2E1	0.0037	0.013	0.013
Leishmania major	hypothetical protein, conserved	0.0758	0.3069	1
Schistosoma mansoni	glutaminase	0.0239	0.0956	0.3249
Brugia malayi	Steroid receptor seven-up type 2	0.0077	0.0297	0.0297
Onchocerca volvulus		0.0013	0.0034	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0007	0.0009	0.0027
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0037	0.013	0.013
Trichomonas vaginalis	Phospholipase C precursor, putative	0.0013	0.0034	0.0024
Loa Loa (eye worm)	acetyltransferase	0.0127	0.0498	0.0498
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0138	0.0189
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0065	0.0244	0.0828
Schistosoma mansoni	zinc finger protein	0.0005	0.0001	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0205	0.0205
Leishmania major	hypothetical protein, conserved	0.0013	0.0034	0.0071
Loa Loa (eye worm)	TAR-binding protein	0.0055	0.0207	0.0207
Echinococcus multilocularis	nibrin	0.0011	0.0026	0.0035
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0035	0.0124	0.0363
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0013	0.0034	0.0022
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0037	0.013	0.0439
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0035	0.0124	0.0363
Echinococcus granulosus	geminin	0.0392	0.1578	0.5359
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0041	0.0148	0.021
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0077	0.0297	0.0297
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0057	0.008
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0077	0.0297	0.0297
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0207	0.0703
Toxoplasma gondii	propionate-CoA ligase	0.0008	0.0012	0.0154
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0167	0.0662	0.0945
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0127	0.0498	0.0711
Schistosoma mansoni	rotamase	0.0036	0.0127	0.0431
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0007	0.0009	0.0011
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0006	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0297	0.0297
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0017	0.0051	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0037	0.013	0.013
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0011	0.0025	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Brugia malayi	TAR-binding protein	0.0055	0.0207	0.0207
Giardia lamblia	Kinase, CMGC MAPK	0.0056	0.0208	0.0183
Treponema pallidum	fructose-bisphosphate aldolase	0.1666	0.6774	1
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0008	0.0012	0.0006
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0012	0.0006
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.0208	0.0198
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0088	0.0249
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0077	0.0297	0.1008
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0012	0.0003
Echinococcus multilocularis	deoxyribonuclease 1 2	0.0013	0.0034	0.0047
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0026	0.0016
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0111	0.0435	0.1476
Brugia malayi	Tyrosine-protein kinase abl-1	0.0007	0.0009	0.0009
Echinococcus granulosus	dnaJ subfamily B	0.0447	0.1804	0.6126
Brugia malayi	protein C24B5.3	0.0007	0.0008	0.0008
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0138	0.0412
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0007	0.0009	0.0027
Brugia malayi	Doublecortin family protein	0.0017	0.0051	0.0051
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0041	0.0148	0.0502
Trypanosoma cruzi	mitochondrial protein 99, putative	0.0013	0.0034	0.0071
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0011	0.0026	0.0013
Schistosoma mansoni	RAR-like nuclear receptor	0.0077	0.0297	0.1008
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0011	0.0026	0.0043
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0077	0.0297	0.1008
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0138	0.0138
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0056	0.0208	0.0639
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0013	0.0034	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0037	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0148	0.0148
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0045	0.0045
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.002	0.0061	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Echinococcus multilocularis	transcription factor btf3	0.0072	0.0273	0.0389
Trypanosoma cruzi	inositol 5-phosphatase 1, putative	0.0013	0.0034	0.0071
Loa Loa (eye worm)	pyruvate kinase	0.0078	0.03	0.03
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.0252	0.0857
Giardia lamblia	Histone acetyltransferase GCN5	0.0034	0.012	0.0095
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0013	0.0034	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0297	0.0297
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0056	0.0208	0.0639
Schistosoma mansoni	growth factor receptor-bound protein	0.0006	0.0005	0.0018
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0013	0.0034	0.0895
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1666	0.6774	0.6771
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0034	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0036	0.0127	0.0127
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0053	0.0198	0.0185
Loa Loa (eye worm)	steroid hormone receptor	0.0077	0.0297	0.0297
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0013	0.0034	0.0034
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0008	0.0012	0.0154
Toxoplasma gondii	ATPase, AAA family protein	0.0011	0.0026	0.0603
Brugia malayi	hypothetical protein	0.0017	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0037	0.0037
Brugia malayi	AMP-binding enzyme family protein	0.0008	0.0012	0.0012
Mycobacterium ulcerans	lipase LipD	0.0039	0.0138	0.0126
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0065	0.0244	0.0759
Onchocerca volvulus		0.0039	0.0138	0.013
Schistosoma mansoni	topbp1	0.0011	0.0026	0.0087
Schistosoma mansoni	hypothetical protein	0.0045	0.0166	0.0563
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0088	0.0231
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0037	0.013	0.0441
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0057	0.0071
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0037	0.013	0.0122
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0007	0.0009	0.0027
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0037	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0138	0.0138
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0138	0.0383
Onchocerca volvulus		0.0077	0.0297	0.0289
Onchocerca volvulus		0.2457	1	1
Plasmodium falciparum	endonuclease/exonuclease/phosphatase family protein, putative	0.0013	0.0034	0.0895
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0011	0.0026	0.0012
Schistosoma mansoni	cpg binding protein	0.0033	0.0116	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0012	0.0012
Echinococcus granulosus	cpg binding protein	0.0033	0.0116	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0037	0.013	0.013
Toxoplasma gondii	peptidylprolyl isomerase	0.0035	0.0124	0.3962
Toxoplasma gondii	pyruvate kinase PyKII	0.004	0.0144	0.468
Mycobacterium ulcerans	pyruvate kinase	0.0078	0.03	0.0287
Plasmodium vivax	basic transcription factor 3b, putative	0.0072	0.0273	0.9091
Plasmodium vivax	replication factor C subunit 1, putative	0.0011	0.0026	0.0603
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0109	0.0109
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0037	0.013	0.0122
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0006	0.0005	0.0018
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.2457	1	1
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Brugia malayi	nuclear receptor NHR-88	0.0037	0.013	0.013
Schistosoma mansoni	hypothetical protein	0.004	0.0144	0.049
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0127	0.0498	0.1692
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0013	0.0034	0.0071
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0088	0.0116
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.002	0.002
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0088	0.0076
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0077	0.0297	0.0297
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0011	0.0025	0.0042
Brugia malayi	hypothetical protein	0.0135	0.053	0.053
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Echinococcus multilocularis	CCR4 NOT transcription complex subunit 6	0.0013	0.0034	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0026	0.0016
Echinococcus multilocularis	protein dispatched 1	0.0054	0.02	0.0284
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0273	0.0263
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.2457	1	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0758	0.3069	0.3063
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0065	0.0244	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0148	0.0148
Loa Loa (eye worm)	pyruvate kinase-PB	0.0055	0.0203	0.0203
Schistosoma mansoni	aldehyde dehydrogenase	0.0053	0.0198	0.0671
Echinococcus multilocularis	microtubule associated protein 2	0.0727	0.2943	0.4207
Mycobacterium ulcerans	glutaminase	0.0239	0.0956	0.0945
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Leishmania major	endonuclease/exonuclease protein-like protein	0.0013	0.0034	0.0071
Loa Loa (eye worm)	nuclear hormone receptor	0.0037	0.013	0.013
Trichomonas vaginalis	pyruvate kinase, putative	0.0078	0.03	0.029
Brugia malayi	exodeoxyribonuclease III family protein	0.0065	0.0244	0.0244
Onchocerca volvulus		0.0039	0.0138	0.013
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0012	0.0006
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.0148	0.0148
Schistosoma mansoni	intermediate filament proteins	0.0029	0.0101	0.0343
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0088	0.0076
Plasmodium vivax	multidomain scavenger receptor, putative	0.0017	0.0051	0.1484
Echinococcus multilocularis	cpg binding protein	0.0033	0.0116	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Echinococcus granulosus	lipoxygenase domain containing protein	0.0017	0.0051	0.0171
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0037	0.0133	0.0123
Schistosoma mansoni	pyruvate kinase	0.0078	0.03	0.1018
Schistosoma mansoni	hypothetical protein	0.0019	0.0057	0.0192
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0013	0.0034	0.0895
Trypanosoma cruzi	pantothenate kinase subunit, putative	0.0014	0.0038	0.0085
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0088	0.0076
Entamoeba histolytica	inositol polyphosphate-5-phosphatase, putative	0.0013	0.0034	0.0022
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0011	0.0026	0.0043
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0077	0.0297	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0135	0.053	0.053
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0037	0.013	0.013
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0057	0.008
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0077	0.0297	0.1006
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0026	0.0016
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0078	0.03	0.0422
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0148	0.0148
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0088	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0077	0.0297	0.0297
Echinococcus multilocularis	synaptojanin 1	0.0013	0.0034	0.0047
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0008	0.0012	0.0006
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0138	0.0129
Schistosoma mansoni	tyrosine kinase	0.0164	0.065	0.2208
Brugia malayi	glutaminase DH11.1	0.0239	0.0956	0.0956
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0013	0.0034	0.0116
Trypanosoma cruzi	transcription factor btf3, putative	0.0072	0.0273	0.0852
Onchocerca volvulus	Pyruvate kinase homolog	0.0078	0.03	0.0292
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0026	0.0016
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0013	0.0034	0.0071
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0077	0.0297	0.1006
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0053	0.0198	0.0185
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0013	0.0034	0.0071
Leishmania major	inositol phosphosphingolipid phospholipase C-Like	0.0013	0.0034	0.0071
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0026	0.0016
Schistosoma mansoni	hypothetical protein	0.0019	0.0057	0.0192
Echinococcus granulosus	Polycystic kidney disease protein	0.0017	0.0051	0.0171
Leishmania major	pyruvate kinase	0.0078	0.03	0.0939
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.0236	0.782
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0057	0.0071
Echinococcus granulosus	thyroid hormone receptor alpha	0.0037	0.013	0.0439
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0012	0.0006
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0138	0.0412
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.2457	1	1
Trichomonas vaginalis	type IV inositol 5-phosphatase, putative	0.0013	0.0034	0.0024
Echinococcus granulosus	lipoxygenase domain containing protein	0.0017	0.0051	0.0171
Echinococcus granulosus	pyruvate kinase	0.004	0.0144	0.0488
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0013	0.0034	0.0071
Echinococcus granulosus	CCR4 NOT transcription complex subunit 6	0.0013	0.0034	0.0113
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0007	0.0009	0.0011
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0013	0.0034	0.0024
Toxoplasma gondii	NAC domain-containing protein	0.0072	0.0273	0.9091
Leishmania major	basic transcription factor 3a, putative	0.0072	0.0273	0.0852
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0116	0.0452	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0088	0.0076
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0048	0.0178	0.0602
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Trichomonas vaginalis	rotamase, putative	0.0035	0.0124	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0088	0.0088
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.1666	0.6774	0.6771
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0138	0.0129
Brugia malayi	beta-lactamase family protein	0.0039	0.0138	0.0138
Brugia malayi	Nuclear hormone receptor E75	0.0037	0.013	0.013
Echinococcus multilocularis	ecdysone induced protein 78C	0.0077	0.0297	0.0423
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0077	0.0297	0.1008
Plasmodium falciparum	exodeoxyribonuclease III, putative	0.0013	0.0034	0.0895
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0007	0.0009	0.0011
Echinococcus multilocularis	pyruvate kinase	0.004	0.0144	0.0205
Plasmodium falciparum	carbon catabolite repressor protein 4, putative	0.0013	0.0034	0.0895
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0037	0.013	0.0184
Echinococcus granulosus	traf and tnf receptor associated protein	0.0013	0.0034	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0037	0.013	0.013
Plasmodium vivax	exodeoxyribonuclease III, putative	0.0013	0.0034	0.0895
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0077	0.0297	0.1006
Trichomonas vaginalis	pyruvate kinase, putative	0.0078	0.03	0.029
Brugia malayi	conserved hypotetical protein	0.0037	0.013	0.013
Brugia malayi	beta-NAC-like protein	0.0072	0.0273	0.0273
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0088	0.0249
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0057	0.0071
Entamoeba histolytica	endonuclease/exonuclease/phosphatase domain containing protein	0.0013	0.0034	0.0022
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0013	0.004
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0008	0.0012	0.0012
Entamoeba histolytica	inositol polyphosphate 5-phosphatase, putative	0.0013	0.0034	0.0022
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0013	0.0034	0.0071
Onchocerca volvulus		0.0039	0.0138	0.013
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0056	0.0208	0.0639
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0065	0.0244	0.0232
Echinococcus granulosus	mitogen activated protein kinase	0.0056	0.0208	0.0704
Leishmania major	peptidyl-prolyl cis-trans isomerase, putative	0.0011	0.0025	0.0042
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0078	0.03	0.0873
Echinococcus granulosus	c src tyrosine kinase	0.0007	0.0009	0.0027
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.1666	0.6774	0.677
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0138	0.0189
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0077	0.0297	0.0423
Echinococcus multilocularis	lamin	0.0029	0.0101	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0037	0.013	0.013
Echinococcus granulosus	ecdysone induced protein 78C	0.0077	0.0297	0.1006
Onchocerca volvulus		0.0031	0.0109	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0297	0.0297
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0123	0.0484	0.1641
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0056	0.0208	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0026
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0037	0.0133	0.0123
Onchocerca volvulus		0.0013	0.0034	0.0026
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0021	0.0028
Trichomonas vaginalis	antibiotic synthetase, putative	0.0008	0.0012	0.0003
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.0001
Brugia malayi	Patched family protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0006	0.0005	0.0005
Onchocerca volvulus		0.0029	0.0101	0.0093
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0059	0.022	0.022
Schistosoma mansoni	lamin	0.0029	0.0101	0.0343
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0061	0.1303
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0007	0.0009	0.0027
Schistosoma mansoni	hypothetical protein	0.0017	0.0051	0.0174
Schistosoma mansoni	coup transcription factor	0.0077	0.0297	0.1008
Schistosoma mansoni	tyrosine kinase	0.0007	0.0009	0.003
Brugia malayi	CHE-14 protein	0.0047	0.0173	0.0173
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0077	0.0297	0.0297
Schistosoma mansoni	bromodomain containing protein	0.0005	0.0001	0.0003
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0088	0.0088
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0011	0.0026	0.004
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0007	0.0011	0.0034
Schistosoma mansoni	hypothetical protein	0.0392	0.1578	0.536
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0057	0.0189
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0013	0.0034	0.0024
Chlamydia trachomatis	pyruvate kinase	0.0078	0.03	1
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0138	0.0383
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0036	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Schistosoma mansoni	cellular tumor antigen P53	0.0055	0.0205	0.0698
Trichomonas vaginalis	skeletal muscle/kidney enriched inositol 5-phosphatase, putative	0.0013	0.0034	0.0024
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0013	0.0034	0.0034
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0013	0.0034	0.0034
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.0148	0.0148
Echinococcus granulosus	transcription factor btf3	0.0072	0.0273	0.0925
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0007	0.0009	0.0027
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0012	0.0012
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0078	0.03	0.0939
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0007	0.0009	0.0011
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0053	0.0198	0.0669
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0013	0.0034	0.0034
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0088	0.0116
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.0101	0.0101
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0138	0.0412
Trypanosoma brucei	protein kinase, putative	0.0056	0.0208	0.0639
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0056	0.0208	0.0639
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0013	0.0034	0.0022
Brugia malayi	ecdysteroid receptor	0.0077	0.0297	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0026	0.0026
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0088	0.0076
Mycobacterium tuberculosis	Probable exported protein	0.0013	0.0034	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0072	0.0273	0.0263
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0008	0.0012	0.0006
Trypanosoma brucei	pyruvate kinase 1, putative	0.0078	0.03	0.0939
Schistosoma mansoni	tar DNA-binding protein	0.0055	0.0207	0.0703
Brugia malayi	Nuclear hormone receptor-like 1	0.0077	0.0297	0.0297
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0088	0.0076
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0013	0.0034	0.0034
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0011	0.0026	0.0603
Echinococcus granulosus	nuclear receptor nhr 48	0.0037	0.013	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0065	0.0244	0.0219
Echinococcus multilocularis	neutral sphingomyelinase	0.0013	0.0034	0.0047
Schistosoma mansoni	rab6-interacting	0.0017	0.0051	0.0174
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0247	0.0987	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0034	0.0034
Trichomonas vaginalis	ap endonuclease, putative	0.0065	0.0244	0.0235
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0077	0.0297	0.0297
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0057	0.0189
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0077	0.0297	0.0297
Brugia malayi	hypothetical protein	0.0037	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0077	0.0297	0.0297
Trypanosoma cruzi	transcription factor btf3, putative	0.0072	0.0273	0.0852

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.048 uM	Inhibition of ITK by DELPHIA assay	ChEMBL.	18823779

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL518932

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1017197