Detailed information for compound 1034374

Basic information

Technical information
  • TDR Targets ID: 1034374
  • Name: 2-(4-hydroxyphenyl)-3-[[4-(2-piperidin-1-ylet hoxy)phenyl]methyl]-1-benzothiophen-6-ol hydr ochloride
  • MW: 496.061 | Formula: C28H30ClNO3S
  • H donors: 2 H acceptors: 2 LogP: 7.47 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)sc(c2Cc1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O.Cl
  • InChi: 1S/C28H29NO3S.ClH/c30-22-8-6-21(7-9-22)28-26(25-13-10-23(31)19-27(25)33-28)18-20-4-11-24(12-5-20)32-17-16-29-14-2-1-3-15-29;/h4-13,19,30-31H,1-3,14-18H2;1H
  • InChiKey: RFGQOKFGIRDXSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-hydroxyphenyl)-3-[[4-[2-(1-piperidyl)ethoxy]phenyl]methyl]benzothiophen-6-ol hydrochloride
  • 2-(4-hydroxyphenyl)-3-[[4-[2-(1-piperidyl)ethoxy]phenyl]methyl]-6-benzothiophenol hydrochloride
  • 2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzyl]benzothiophen-6-ol hydrochloride

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Smad4 0.0019 0.0006 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0013
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0031 0.0848
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0013 0.0393
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0007 0.0011
Echinococcus granulosus dna polymerase kappa 0.0062 0.0052 0.0048
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0096 0.0184
Treponema pallidum phosphoglycerate kinase 0.0168 0.0164 0.6139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0007 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0062 0.0112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0015 0.0028
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0009
Schistosoma mansoni glycogen phosphorylase 0.4917 0.519 0.5188
Loa Loa (eye worm) hypothetical protein 0.0026 0.0014 0.0026
Echinococcus granulosus FTZ F1 alpha 0.002 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0252 0.0253 0.0486
Echinococcus multilocularis GPCR, family 2 0.0033 0.0021 0.0017
Brugia malayi Phosphoglycerate kinase 0.0062 0.0051 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.2126 0.2236 1
Loa Loa (eye worm) hypothetical protein 0.0252 0.0253 0.0486
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0262 0.0263 0.0259
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.0004 0.0161
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0011 0.0324
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0017 0.0004 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0098 0.0182
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0262 0.0263 0.0497
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0012 0.0039
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0012 0.0039
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0021 0.0008 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0033 0.0057
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0052 0.1602
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0252 0.0253 0.1128
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0007 0.0088
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0236 0.0231
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0168 0.0164 0.5303
Onchocerca volvulus 0.0024 0.0011 0.0014
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0013 0.0046
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0062 0.0052 0.0048
Leishmania major DNA damage repair protein, putative 0.0019 0.0007 0.0075
Mycobacterium leprae Probable lipase LipE 0.0252 0.0253 0.9612
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0006 0.001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0011 0.0014
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0137 0.4391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0031 0.0906
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0007 0.0003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0006 0.001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0007 0.0003
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0007 0.0002
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0012 0.0049
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0011 0.0038
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0041 0.1232
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0007 0.0003
Schistosoma mansoni coup transcription factor 0.002 0.0007 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.003 0.0057
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0021 0.0017
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0007 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0052 0.1549
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0007 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0031 0.0867
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0055 0.1662
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0007 0.0011
Loa Loa (eye worm) ctsf protein 0.0017 0.0004 0.0007
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0033 0.0063
Loa Loa (eye worm) hypothetical protein 0.0041 0.003 0.0057
Toxoplasma gondii ABC1 family protein 0.0252 0.0253 0.9616
Echinococcus granulosus basement membrane specific heparan sulfate 0.0021 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0013 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0033 0.0062
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0052 0.0098
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0013 0.0393
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0011 0.0236
Echinococcus granulosus lamin dm0 0.0026 0.0014 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0004 0.0015
Mycobacterium ulcerans hypothetical protein 0.0024 0.0011 0.0038
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Echinococcus granulosus glycogen phosphorylase 0.4917 0.519 0.5188
Toxoplasma gondii hypothetical protein 0.0049 0.0038 0.1428
Schistosoma mansoni thyroid hormone receptor 0.002 0.0007 0.0003
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0006 0.0009
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0007 0.0003
Toxoplasma gondii target of rapamycin (TOR), putative 0.0099 0.0091 0.3451
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0104 0.0096 0.0184
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0154 0.0687
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0007 0.0011
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0021 0.0008 0.0015
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0021 0.0008 0.0014
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0011 0.0236
Leishmania major DNA polymerase eta, putative 0.0062 0.0052 0.1585
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0007 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0004 0.0001
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0045 0.0033 0.0029
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0006 0.0004
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0007 0.0033
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0031 0.0906
Onchocerca volvulus 0.0021 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0061 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.0127 0.0237
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0007 0.0248
Loa Loa (eye worm) hypothetical protein 0.0636 0.066 0.127
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0013 0.0393
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0007 0.0013
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0007 0.0003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0011 0.0038
Brugia malayi MH1 domain containing protein 0.0023 0.001 0.0018
Schistosoma mansoni ap endonuclease 0.0018 0.0006 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.003
Trypanosoma brucei unspecified product 0.0043 0.0031 0.0867
Mycobacterium ulcerans thioesterase 0.002 0.0007 0.002
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0021 0.0008 0.0004
Echinococcus granulosus low density lipoprotein receptor ldl 0.0021 0.0008 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0033 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0033 0.0057
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0007 0.0011
Echinococcus granulosus geminin 0.0165 0.0161 0.0157
Echinococcus multilocularis lamin 0.0026 0.0014 0.001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0009
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0021 0.0008 0.0004
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0013
Mycobacterium leprae conserved hypothetical protein 0.0252 0.0253 0.9612
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0011 0.0048
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0018 0.0673
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0052 0.1549
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0007 0.0013
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0062 0.0052 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0262 0.0263 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0063 0.0053 0.1572
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0055 0.0045 0.1302
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0051 0.1579
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0004 0.0007
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0051 0.1561
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0007 0.0096
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.003 0.0057
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0013 0.0483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0055 0.1662
Giardia lamblia DNA damage repair protein 0.0019 0.0007 0.0002
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0005 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0091 0.0168
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0018 0.0013
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0021 0.0008 0.0014
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0137 0.4415
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0045 0.0033 0.0029
Giardia lamblia GTOR 0.0133 0.0127 0.0234
Schistosoma mansoni phosphoglycerate kinase 0.0168 0.0164 0.0159
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0062 0.0052 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0091 0.0168
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0014 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0098 0.0182
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.003 0.0026
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0018 0.0013
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0012 0.0332
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0048 0.0037 0.0033
Entamoeba histolytica protein kinase rad3, putative 0.0025 0.0013 0.0016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0013 0.0023
Schistosoma mansoni ap endonuclease 0.0018 0.0006 0.0001
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0025 0.0013 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0062 0.0113
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0168 0.0164 0.622
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0168 0.0164 0.0308
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0006 0.0001
Toxoplasma gondii cathepsin CPL 0.0017 0.0004 0.0162
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0252 0.0253 0.1128
Brugia malayi basement membrane proteoglycan precursor 0.0021 0.0008 0.0014
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.0305 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0004 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0007 0.0011
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0171 0.0168 0.6331
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0051 0.1579
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0055 0.1662
Trichomonas vaginalis glycogen phosphorylase, putative 0.4917 0.519 1
Onchocerca volvulus 0.0252 0.0253 0.0479
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0013 0.0056
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0066 0.2499
Entamoeba histolytica glycogen phosphorylase, putative 0.2126 0.2236 0.4304
Leishmania major phosphatidylinositol 3-kinase, putative 0.0045 0.0033 0.0964
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0031 0.0867
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0021 0.0008 0.0014
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.003 0.0026
Trypanosoma brucei phosphoglycerate kinase 0.0168 0.0164 0.5273
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0006 0.0042
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0022 0.0018
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0253 0.0254 0.025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0007 0.0096
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0033 0.0029
Brugia malayi MH1 domain containing protein 0.0041 0.003 0.0056
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0007 0.0003
Brugia malayi MH1 domain containing protein 0.0041 0.003 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0018 0.0013
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0007 0.0248
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0014 0.0026
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0007 0.0033
Loa Loa (eye worm) phosphatidylinositol 3 0.0133 0.0127 0.0244
Onchocerca volvulus 0.0021 0.0008 0.0008
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0007 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0055 0.1662
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0007 0.0003
Trypanosoma brucei unspecified product 0.0062 0.0052 0.1549
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0045 0.0033 0.0926
Schistosoma mansoni microtubule-associated protein tau 0.9461 1 1
Loa Loa (eye worm) nuclear factor I 0.0023 0.001 0.0019
Echinococcus multilocularis microtubule associated protein 2 0.9461 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0007 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0066 0.2059
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0062 0.0052 0.0093
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0006 0.0063
Loa Loa (eye worm) hypothetical protein 0.0168 0.0164 0.0314
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0033 0.0029
Leishmania major phosphoglycerate kinase C, glycosomal 0.0168 0.0164 0.5293
Leishmania major cathepsin L-like protease 0.0065 0.0055 0.1697
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0021 0.0039
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0011 0.0324
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0006 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0011 0.0038
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0171 0.0168 0.0747
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0019 0.0007 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0006 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0007 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0007 0.0096
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0007 0.0003
Onchocerca volvulus Glycogen phosphorylase homolog 0.4917 0.519 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0007 0.0003
Trypanosoma brucei phosphoglycerate kinase 0.0168 0.0164 0.5273
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0066 0.2375
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0033 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0011 0.002
Mycobacterium tuberculosis Possible penicillin-binding protein 0.161 0.169 0.7557
Mycobacterium tuberculosis Conserved protein 0.0252 0.0253 0.1128
Loa Loa (eye worm) hypothetical protein 0.0023 0.001 0.0019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0062 0.0052 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0031 0.0867
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0051 0.1579
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0052 0.1549
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0066 0.2375
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0031 0.0906
Onchocerca volvulus 0.0021 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Schistosoma mansoni hypothetical protein 0.0021 0.0008 0.0004
Schistosoma mansoni hypothetical protein 0.0033 0.0021 0.0017
Brugia malayi Pre-SET motif family protein 0.0208 0.0206 0.0396
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0012 0.0049
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0262 0.0263 0.1164
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0019 0.0007 0.0002
Brugia malayi beta-lactamase family protein 0.0252 0.0253 0.0485
Mycobacterium tuberculosis Probable esterase LipL 0.0252 0.0253 0.1128
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0007 0.0013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0005 0.0009
Loa Loa (eye worm) beta-lactamase 0.0252 0.0253 0.0486
Schistosoma mansoni transcription factor LCR-F1 0.0253 0.0254 0.025
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0005 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0098 0.0182
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0052 0.1602
Leishmania major mitochondrial DNA polymerase beta 0.0301 0.0305 1
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0021 0.0008 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0052 0.1602
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0006 0.0001
Brugia malayi hypothetical protein 0.0075 0.0066 0.0125
Leishmania major hypothetical protein, conserved 0.0075 0.0066 0.2042
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0137 0.4426
Trypanosoma cruzi hypothetical protein, conserved 0.0252 0.0253 0.8264
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0007 0.0011
Brugia malayi MH1 domain containing protein 0.0023 0.001 0.0018
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0013 0.0056
Echinococcus granulosus beta LACTamase domain containing family member 0.0252 0.0253 0.0249
Onchocerca volvulus 0.0636 0.066 0.1264
Loa Loa (eye worm) glycogen phosphorylase 0.4917 0.519 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0012 0.002
Echinococcus multilocularis peptidase Clp (S14 family) 0.0171 0.0168 0.0163
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0168 0.0164 0.622
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0033
Leishmania major DNA polymerase kappa, putative 0.0019 0.0007 0.0075
Loa Loa (eye worm) hypothetical protein 0.0075 0.0066 0.0126
Brugia malayi AMP-binding enzyme family protein 0.003 0.0017 0.0031
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.0007 0.0141
Echinococcus multilocularis Smad4 0.0041 0.003 0.0026
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0062 0.0051 0.1579
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0007 0.0096
Entamoeba histolytica hypothetical protein 0.0253 0.0254 0.0482
Mycobacterium leprae Polyketide synthase Pks13 0.0036 0.0024 0.0817
Echinococcus granulosus phosphoglycerate kinase 1 0.0168 0.0164 0.0159
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0045 0.0033 0.0983
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0007 0.0003
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0062 0.0052 0.023
Onchocerca volvulus 0.0237 0.0237 0.0448
Mycobacterium ulcerans thioesterase TesA 0.002 0.0007 0.002
Trichomonas vaginalis glycogen phosphorylase, putative 0.4917 0.519 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0062 0.0112
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0168 0.0164 0.5303
Echinococcus granulosus dna polymerase eta 0.0062 0.0052 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0033 0.0057
Mycobacterium ulcerans hypothetical protein 0.0159 0.0154 0.0677
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0007 0.0003
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0018 0.0013
Brugia malayi enteropeptidase precursor 0.0021 0.0008 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0004 0.0001
Chlamydia trachomatis glycogen phosphorylase 0.4917 0.519 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0007 0.0011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0004 0.0015
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0007 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0033 0.0057
Trypanosoma cruzi target of rapamycin kinase 3 0.0106 0.0098 0.3134
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0133 0.0127 0.4085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0062 0.0113
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0006 0.0004
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0133 0.0127 0.0123
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0055 0.1715
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0007 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0033 0.0029
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0007 0.0003
Entamoeba histolytica hypothetical protein 0.0253 0.0254 0.0482
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0011 0.0038
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0062 0.0052 0.1585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0055 0.1662
Echinococcus multilocularis smad 0.0041 0.003 0.0026
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0262 0.0263 0.0497
Toxoplasma gondii exonuclease III APE 0.0018 0.0006 0.021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0013 0.0023
Schistosoma mansoni smad1 5 8 and 0.0041 0.003 0.0026
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0007 0.0088
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0055 0.1662
Schistosoma mansoni hypothetical protein 0.0033 0.0021 0.0017
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0013 0.0056
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0045 0.0033 0.0964
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0021 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0018 0.0013
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0021 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0784 0.0816 0.0812
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0007 0.0013
Giardia lamblia Phosphoglycerate kinase 0.0168 0.0164 0.0305
Brugia malayi nuclear hormone receptor 0.002 0.0007 0.0011
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0045 0.0033 0.0926
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0007 0.0013
Trichomonas vaginalis penicillin-binding protein, putative 0.0252 0.0253 0.048
Loa Loa (eye worm) hypothetical protein 0.0033 0.0021 0.0039
Echinococcus granulosus smad 0.0041 0.003 0.0026
Echinococcus granulosus glycogen phosphorylase 0.4917 0.519 0.5188
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0052 0.1549
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0007 0.0011
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0052 0.1549
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0133 0.0127 0.4085
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0052 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Echinococcus multilocularis tumor protein p63 0.4348 0.4587 0.4585
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.0127 0.0237
Schistosoma mansoni smad1 5 8 and 0.0041 0.003 0.0026
Mycobacterium tuberculosis Conserved protein 0.0252 0.0253 0.1128
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0133 0.0127 0.0242
Schistosoma mansoni hypothetical protein 0.0071 0.0061 0.0057
Onchocerca volvulus 0.0021 0.0008 0.0008
Trichomonas vaginalis DNA polymerase eta, putative 0.0062 0.0052 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.007 0.0128
Schistosoma mansoni lamin 0.0026 0.0014 0.001
Schistosoma mansoni Smad4 0.0041 0.003 0.0026
Schistosoma mansoni terminal deoxycytidyl transferase 0.0062 0.0052 0.0048
Loa Loa (eye worm) hypothetical protein 0.0252 0.0253 0.0486
Leishmania major cathepsin L-like protease 0.0065 0.0055 0.1697
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0052 0.1549
Trypanosoma brucei hypothetical protein, conserved 0.0252 0.0253 0.8253
Schistosoma mansoni hypothetical protein 0.0019 0.0007 0.0002
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0012 0.0049
Brugia malayi MH2 domain containing protein 0.0019 0.0006 0.0009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0021
Schistosoma mansoni phosphoglycerate kinase 0.0168 0.0164 0.0159
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0021 0.0008 0.0004
Giardia lamblia DINP protein human, muc B family 0.0062 0.0052 0.009
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0021 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0004 0.0006
Brugia malayi MH2 domain containing protein 0.0609 0.0631 0.1213
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Echinococcus granulosus low density lipoprotein receptor ldl 0.0021 0.0008 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0033 0.0029
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0055 0.1715
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0066 0.2375
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0206 0.0397
Entamoeba histolytica glycogen phosphorylase, putative 0.4917 0.519 1
Loa Loa (eye worm) fibroinase 0.0017 0.0004 0.0007
Brugia malayi intermediate filament protein 0.0026 0.0014 0.0025
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0006 0.0001
Toxoplasma gondii hypothetical protein 0.009 0.0081 0.3098
Schistosoma mansoni glycogen phosphorylase 0.2126 0.2236 0.2233
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0021 0.0008 0.0014
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0021 0.0008 0.0004
Giardia lamblia Glycogen phosphorylase 0.4917 0.519 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0037 0.0069
Mycobacterium ulcerans hypothetical protein 0.0019 0.0007 0.0016
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.0007 0.0016
Plasmodium falciparum phosphoglycerate kinase 0.0168 0.0164 0.6158
Schistosoma mansoni DNA polymerase eta 0.0062 0.0052 0.0048
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0028 0.0016 0.0599
Onchocerca volvulus 0.0048 0.0037 0.0063
Schistosoma mansoni intermediate filament proteins 0.0026 0.0014 0.001
Echinococcus granulosus tumor protein p63 0.4348 0.4587 0.4585
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0237 0.045
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0106 0.0098 0.309
Trypanosoma cruzi DNA polymerase kappa, putative 0.0062 0.0052 0.1602
Loa Loa (eye worm) MH2 domain-containing protein 0.0609 0.0631 0.1214
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0007 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0013 0.0018
Schistosoma mansoni hypothetical protein 0.0253 0.0254 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0098 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0007 0.0011
Brugia malayi hypothetical protein 0.0049 0.0037 0.007
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0011 0.0048
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.0034 0.0064
Mycobacterium tuberculosis Probable lipase LipE 0.0252 0.0253 0.1128
Schistosoma mansoni Smad4 0.0019 0.0006 0.0001
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.0051 0.1525
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0252 0.0253 0.0249
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0003 0.01
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0013 0.0046
Onchocerca volvulus 0.002 0.0007 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0004 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0011 0.0038
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0041 0.1223
Brugia malayi Calcium binding EGF domain containing protein 0.0021 0.0008 0.0014
Loa Loa (eye worm) transcription factor SMAD2 0.0609 0.0631 0.1214
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.0052 0.1602
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0133 0.0127 0.4072
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0021 0.0008 0.0014
Schistosoma mansoni lamin 0.0026 0.0014 0.001
Schistosoma mansoni hypothetical protein 0.0165 0.0161 0.0157
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0171 0.0168 0.0747
Entamoeba histolytica glycogenphosphorylase, putative 0.2126 0.2236 0.4304
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0006 0.0009
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.009 0.0081 0.295
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0013 0.0301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0007 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0055 0.1662
Loa Loa (eye worm) hypothetical protein 0.003 0.0018 0.0033
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0021 0.0017
Brugia malayi hypothetical protein 0.0657 0.0681 0.1311
Schistosoma mansoni hypothetical protein 0.0165 0.0161 0.0157
Brugia malayi Phosphoglycerate kinase 0.0168 0.0164 0.0313
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.009 0.0081 0.2985
Brugia malayi polk-prov protein 0.0019 0.0007 0.0011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0021 0.0017
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0262 0.0263 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0096 0.0183
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0066 0.2008
Loa Loa (eye worm) hypothetical protein 0.0236 0.0236 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0007 0.0011
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0007 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0007 0.0003
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0013 0.0008
Brugia malayi steroid hormone receptor 0.002 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0011 0.0021
Echinococcus granulosus Smad4 0.0041 0.003 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0011 0.0236
Schistosoma mansoni smad 0.0041 0.003 0.0026
Trypanosoma brucei unspecified product 0.0043 0.0031 0.0867
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0055 0.1662
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0006 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.0252 0.0253 0.048
Loa Loa (eye worm) hypothetical protein 0.0657 0.0681 0.1312
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0007 0.0248
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0252 0.0253 0.048
Loa Loa (eye worm) AMP-binding enzyme family protein 0.003 0.0017 0.0033
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0007 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0262 0.0263 0.0506
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0062 0.0052 0.0099
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0004 0.0006
Onchocerca volvulus 0.0021 0.0008 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0055 0.1662
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0021 0.0008 0.0014
Schistosoma mansoni survival motor neuron protein 0.0048 0.0037 0.0033
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0036 0.0024 0.0106
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0007 0.0003
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0045 0.0033 0.0983
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0021 0.0008 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0004 0.0001
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.003 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Entamoeba histolytica glycogen phosphorylase, putative 0.4917 0.519 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0252 0.0253 0.0486
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0018 0.0013
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0262 0.0263 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0007 0.0013
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0168 0.0164 0.6177
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0045 0.0033 0.0029
Trichomonas vaginalis esterase, putative 0.0252 0.0253 0.048
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0036 0.0024 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0052 0.1549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0091 0.0168
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0252 0.0253 0.0249
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0018 0.0013
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0017 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0091 0.0168
Schistosoma mansoni fkbp-rapamycin associated protein 0.0025 0.0013 0.0008
Leishmania major DNA polymerase kappa, putative 0.0062 0.0052 0.1585
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0021 0.0008 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0052 0.1549
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0007 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0091 0.0168
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0012 0.0039
Brugia malayi hypothetical protein 0.0236 0.0236 0.0452
Loa Loa (eye worm) cysteine protease 0.0017 0.0004 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0052 0.1549
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0011 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0106 0.0098 0.0182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0004 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0007 0.0003
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0006
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0133 0.0127 0.4047
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0021 0.0008 0.0014
Schistosoma mansoni hypothetical protein 0.0034 0.0022 0.0018
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0012 0.0332
Echinococcus granulosus intermediate filament protein 0.0026 0.0014 0.001
Echinococcus multilocularis musashi 0.0026 0.0014 0.001
Mycobacterium tuberculosis Probable lipase LipD 0.0252 0.0253 0.1128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0252 0.0253 0.8264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0004 0.0001
Echinococcus multilocularis Glycosyl transferase, family 35 0.4917 0.519 0.5188
Onchocerca volvulus Fatty acid synthase homolog 0.0043 0.0032 0.0054
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0262 0.0263 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0007 0.0003
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0006 0.0002
Entamoeba histolytica glycogen phosphorylase, putative 0.2126 0.2236 0.4304
Schistosoma mansoni smad1 5 8 and 0.0041 0.003 0.0026
Onchocerca volvulus 0.003 0.0018 0.0026
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0014 0.0019
Brugia malayi MH2 domain containing protein 0.0041 0.003 0.0056
Trypanosoma brucei phosphoglycerate kinase, putative 0.0062 0.0051 0.1525
Mycobacterium ulcerans phosphoglycerate kinase 0.0168 0.0164 0.0719
Leishmania major DNA polymerase eta, putative 0.0019 0.0007 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0052 0.1549
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0021 0.0038
Schistosoma mansoni hypothetical protein 0.0033 0.0021 0.0017
Loa Loa (eye worm) Smad1 0.0041 0.003 0.0057
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0168 0.0164 0.0308
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0006 0.0049
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0019 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0013
Mycobacterium ulcerans polyketide synthase Pks13 0.0036 0.0024 0.0095
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.009 0.0081 0.302
Plasmodium vivax SET domain protein, putative 0.003 0.0018 0.0519
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0006 0.0063
Mycobacterium ulcerans beta-lactamase 0.0252 0.0253 0.1119
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0133 0.0127 0.0236
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0007 0.0033
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0013 0.0008
Brugia malayi ecdysteroid receptor 0.002 0.0007 0.0011
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0021 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0007 0.0011
Mycobacterium tuberculosis Probable hydrolase 0.0252 0.0253 0.1128
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0252 0.0253 0.048
Schistosoma mansoni thyroid hormone receptor 0.002 0.0007 0.0003
Mycobacterium ulcerans polyketide synthase 0.0024 0.0012 0.0039
Echinococcus granulosus lamin 0.0026 0.0014 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0133 0.0127 0.0237
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0011 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0004 0.0001
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0022 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0052 0.1549
Onchocerca volvulus 0.003 0.0017 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0052 0.1549
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0168 0.0164 0.0729
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0004 0.0001
Plasmodium vivax phosphoglycerate kinase, putative 0.0168 0.0164 0.6158
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0025 0.0013 0.0016
Brugia malayi Pre-SET motif family protein 0.003 0.0018 0.0032
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0007 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0096 0.0183
Chlamydia trachomatis phosphoglycerate kinase 0.0168 0.0164 0.0306
Echinococcus granulosus GPCR family 2 0.0033 0.0021 0.0017
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0021 0.0008 0.0004
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0021 0.0008 0.0004
Onchocerca volvulus 0.0026 0.0014 0.0019
Brugia malayi Probable ClpP-like protease 0.0262 0.0263 0.0505
Mycobacterium ulcerans hypothetical protein 0.0252 0.0253 0.1119
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.009 0.0081 0.2985
Onchocerca volvulus 0.0049 0.0038 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0055 0.1662
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0006 0.0001
Onchocerca volvulus 0.0021 0.0008 0.0008
Echinococcus multilocularis dna polymerase kappa 0.0062 0.0052 0.0048
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0133 0.0127 0.0123
Onchocerca volvulus 0.0657 0.0681 0.1305
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0013 0.0008
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0066 0.2059
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.003 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0236 0.0231
Echinococcus granulosus basement membrane specific heparan sulfate 0.0021 0.0008 0.0004
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0052 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0016 0.0023
Loa Loa (eye worm) hypothetical protein 0.0071 0.0061 0.0117
Mycobacterium ulcerans lipase LipD 0.0252 0.0253 0.1119
Plasmodium vivax hypothetical protein, conserved 0.0252 0.0253 0.961
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.003 0.0026
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0055 0.1715
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0012
Brugia malayi FAT domain containing protein 0.0019 0.0007 0.0011
Mycobacterium ulcerans esterase/lipase LipP 0.0252 0.0253 0.1119
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0051 0.1579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.007 0.0128
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0006
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0252 0.0253 0.1128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0091 0.0168
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0262 0.0263 1
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0007 0.0003
Brugia malayi CUB domain containing protein 0.0021 0.0008 0.0014
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.0305 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0007 0.0003
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0025 0.0013 0.0008
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0006 0.0012
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0133 0.0127 0.4072
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0011 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0033 0.0029
Brugia malayi MH2 domain containing protein 0.0041 0.003 0.0056
Entamoeba histolytica hypothetical protein 0.0025 0.0013 0.0016
Entamoeba histolytica hypothetical protein 0.0253 0.0254 0.0482
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0262 0.0263 1
Schistosoma mansoni smad 0.0019 0.0006 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0007 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0011 0.0038
Mycobacterium ulcerans DNA polymerase IV 0.0062 0.0052 0.0219
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0113 0.0106 0.0198
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0011 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0009
Echinococcus multilocularis beta LACTamase domain containing family member 0.0252 0.0253 0.0249
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0301 0.0305 1
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0021 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0091 0.0168
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.2126 0.2236 1
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0021 0.0008 0.0008
Brugia malayi nuclear receptor NHR-88 0.002 0.0007 0.0011
Leishmania major cathepsin L-like protease 0.0065 0.0055 0.1697
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0062 0.0113
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0004 0.0015
Echinococcus multilocularis low density lipoprotein receptor protein 0.0021 0.0008 0.0004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0007 0.0003
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0133 0.0127 0.0236
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Leishmania major phosphoglycerate kinase B, cytosolic 0.0168 0.0164 0.5293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Entamoeba histolytica hypothetical protein 0.0253 0.0254 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0052 0.1549
Leishmania major hypothetical protein, conserved 0.0252 0.0253 0.826
Echinococcus multilocularis phosphoglycerate kinase 1 0.0168 0.0164 0.0159
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0049 0.1516
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0055 0.1715
Brugia malayi Smad1 0.0041 0.003 0.0056
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0021 0.0008 0.0004
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0012 0.0039
Schistosoma mansoni glycogen phosphorylase 0.4917 0.519 0.5188
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0021 0.0008 0.0004
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0262 0.0263 0.0259
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0021 0.0008 0.0004
Toxoplasma gondii type I fatty acid synthase, putative 0.0027 0.0014 0.054
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0106 0.0098 0.3119
Brugia malayi Cathepsin L-like precursor 0.0017 0.0004 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0062 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.008 0.0148
Echinococcus multilocularis glycogen phosphorylase 0.4917 0.519 0.5188
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.0007 0.0169
Echinococcus multilocularis dna polymerase eta 0.0062 0.0052 0.0048
Entamoeba histolytica phosphoglycerate kinase, putative 0.0168 0.0164 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0007 0.0011
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0021 0.0008 0.0004
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0021 0.0008 0.0004
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0133 0.0127 0.0123
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0009
Trichomonas vaginalis D-aminoacylase, putative 0.0252 0.0253 0.048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0252 0.0253 0.0486
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0033 0.0063
Brugia malayi beta-lactamase 0.0252 0.0253 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0069 0.0127
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0021 0.0008 0.0015
Echinococcus granulosus low density lipoprotein receptor protein 0.0021 0.0008 0.0004
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0007 0.0005
Onchocerca volvulus 0.0026 0.0014 0.0019
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0014 0.0025
Loa Loa (eye worm) hypothetical protein 0.0252 0.0253 0.0486
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0025 0.0013 0.0008
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0262 0.0263 1
Schistosoma mansoni hypothetical protein 0.0021 0.0008 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0033 0.0062
Schistosoma mansoni peptidase Clp (S14 family) 0.0262 0.0263 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Onchocerca volvulus Arrow homolog 0.0021 0.0008 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0069 0.0127
Onchocerca volvulus 0.0252 0.0253 0.0479
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.0007 0.003
Echinococcus multilocularis glycogen phosphorylase 0.4917 0.519 0.5188
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0252 0.0253 0.1119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0055 0.1662
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0007 0.0033
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0004 0.0007
Entamoeba histolytica deoxycytidyl transferase, putative 0.0062 0.0052 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0033 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0007 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0062 0.0112
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0252 0.0253 0.0486
Brugia malayi beta-lactamase family protein 0.0252 0.0253 0.0485
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0004 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0007 0.0003
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0006 0.0022
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0023 0.0011 0.0046
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0168 0.0164 0.6139
Schistosoma mansoni hypothetical protein 0.0033 0.0021 0.0017
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0007 0.0033
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0013 0.0239
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0012
Echinococcus multilocularis geminin 0.0165 0.0161 0.0157
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0015
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.007 0.0128
Echinococcus granulosus peptidase Clp S14 family 0.0171 0.0168 0.0163
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0253 0.0254 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0024 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0004 0.0001
Echinococcus granulosus Glycosyl transferase family 35 0.4917 0.519 0.5188
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0023 0.0011 0.0046
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.003 0.0017 0.0075
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0021 0.0008 0.0014
Echinococcus multilocularis lamin dm0 0.0026 0.0014 0.001
Brugia malayi carbohydrate phosphorylase 0.4917 0.519 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0052 0.0099
Schistosoma mansoni cellular tumor antigen P53 0.0636 0.066 0.0656
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0252 0.0253 0.0485
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0011 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0086 0.0077 0.0142
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0262 0.0263 0.1164
Mycobacterium ulcerans polyketide synthase 0.0026 0.0013 0.0046
Mycobacterium tuberculosis Conserved protein 0.0252 0.0253 0.1128
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.0052 0.1549
Brugia malayi hypothetical protein 0.0253 0.0254 0.0488
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0133 0.0127 0.4047
Onchocerca volvulus 0.0252 0.0253 0.0479

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.47 mg kg-1 In vivo inhibition of estrogen-stimulated uterine weight gain in immature rats on peroral administration ChEMBL. 9154963
IC50 (functional) = 0.19 nM Inhibition of estrogen-induced proliferation in human MCF-7 breast cancer cells ChEMBL. 9154963

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 9154963

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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