Detailed information for compound 104823

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 472.574 | Formula: C26H36N2O6
  • H donors: 4 H acceptors: 5 LogP: -0.2 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C1Cc2ccc(c3c2[C@@]2([C@]1(O)CCC([C@H]2O3)NC(=O)CCCC(=O)O)C)O)CC1CC1
  • InChi: 1S/C26H36N2O6/c1-3-28(14-15-7-8-15)19-13-16-9-10-18(29)23-22(16)25(2)24(34-23)17(11-12-26(19,25)33)27-20(30)5-4-6-21(31)32/h9-10,15,17,19,24,29,33H,3-8,11-14H2,1-2H3,(H,27,30)(H,31,32)/t17?,19?,24-,25-,26+/m0/s1
  • InChiKey: QNPXKBWUHFWCIG-XUQYGIOOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major alpha tubulin 0.002 0.0101 0.2648
Brugia malayi intermediate filament protein 0.0079 0.054 0.1042
Echinococcus granulosus tumor protein p63 0.0329 0.24 0.4045
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0079 0.054 0.1042
Plasmodium falciparum alpha tubulin 2 0.002 0.0101 0.2648
Schistosoma mansoni alpha tubulin 0.002 0.0101 0.0157
Echinococcus multilocularis survival motor neuron protein 1 0.0692 0.5109 0.8628
Onchocerca volvulus 0.0079 0.054 0.5293
Echinococcus granulosus tubulin alpha 1C chain 0.002 0.0101 0.0157
Leishmania major alpha tubulin 0.002 0.0101 0.2648
Trypanosoma brucei epsilon tubulin 0.002 0.0101 0.2648
Echinococcus multilocularis tubulin beta 1 chain 0.0052 0.034 0.0562
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0044 0.0367
Leishmania major beta tubulin 0.0052 0.034 1
Schistosoma mansoni tubulin subunit beta 0.0052 0.034 0.0562
Echinococcus multilocularis musashi 0.0079 0.054 0.0899
Schistosoma mansoni lamin 0.0079 0.054 0.0899
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0133 0.0942 0.1579
Echinococcus multilocularis tubulin alpha chain 0.002 0.0101 0.0157
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0321 0.9424
Schistosoma mansoni alpha tubulin 0.002 0.0101 0.0157
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0052 0.034 0.0562
Schistosoma mansoni hypothetical protein 0.0046 0.0294 0.0483
Schistosoma mansoni hypothetical protein 0.0046 0.0294 0.0483
Leishmania major beta tubulin 0.0052 0.034 1
Leishmania major alpha tubulin 0.002 0.0101 0.2648
Leishmania major beta tubulin 0.0052 0.034 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0321 0.268
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.002 0.0024
Schistosoma mansoni lamin 0.0079 0.054 0.0899
Trypanosoma brucei beta tubulin 0.0052 0.034 1
Trypanosoma brucei alpha tubulin 0.002 0.0101 0.2648
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0054 0.0348 0.0667
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.002 0.0031
Trypanosoma brucei alpha tubulin 0.002 0.0101 0.2648
Loa Loa (eye worm) tubulin beta-4 chain 0.0052 0.034 0.0651
Leishmania major alpha tubulin 0.002 0.0101 0.2648
Plasmodium vivax tubulin beta chain, putative 0.0052 0.034 1
Trypanosoma cruzi epsilon tubulin, putative 0.002 0.0101 0.2648
Schistosoma mansoni hypothetical protein 0.08 0.5921 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0044 0.0367
Echinococcus granulosus lamin 0.0079 0.054 0.0899
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0022 0.022
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0022 0.0019
Schistosoma mansoni hypothetical protein 0.0046 0.0294 0.0483
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0093 0.0144
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.0367
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0022 0.0024
Schistosoma mansoni lipoxygenase 0.0019 0.0093 0.0144
Schistosoma mansoni thyroid hormone receptor 0.001 0.0022 0.0024
Echinococcus multilocularis microtubule associated protein 2 0.067 0.495 0.8358
Giardia lamblia Beta tubulin 0.0052 0.034 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0022 0.022
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0022 0.0028
Brugia malayi hypothetical protein 0.0121 0.085 0.165
Trichomonas vaginalis tubulin, putative 0.0052 0.034 0.2836
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0869 0.1457
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0022 0.0024
Toxoplasma gondii beta-1 tubulin, putative 0.0052 0.034 0.4462
Loa Loa (eye worm) tubulin alpha 2 0.0012 0.0035 0.0053
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0093 0.0773
Echinococcus granulosus tubulin gamma 1 chain 0.002 0.0101 0.0157
Leishmania major beta tubulin 0.0052 0.034 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0093 0.2387
Trichomonas vaginalis conserved hypothetical protein 0.001 0.002 0.017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0022 0.0028
Leishmania major beta tubulin 0.0052 0.034 1
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.002 0.017
Echinococcus multilocularis tubulin gamma 1 chain 0.002 0.0101 0.0157
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.002 1
Brugia malayi Tubulin beta chain 0.0012 0.0035 0.0053
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1347 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0294 0.056
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0022 0.0024
Echinococcus multilocularis dnaJ subfamily B 0.08 0.5921 1
Loa Loa (eye worm) BEN-1 protein 0.0052 0.034 0.0651
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0053 0.0076
Schistosoma mansoni tubulin subunit beta 0.0009 0.0015 0.0012
Echinococcus granulosus tubulin alpha chain 0.002 0.0101 0.0157
Brugia malayi Tubulin alpha chain 0.002 0.0101 0.0183
Loa Loa (eye worm) tubulin beta-1 chain 0.0052 0.034 0.0651
Brugia malayi TAR-binding protein 0.0123 0.0869 0.1689
Onchocerca volvulus 0.0019 0.0093 0.0741
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0022 0.0024
Schistosoma mansoni survival motor neuron protein 0.0141 0.1002 0.168
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0044 0.0367
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.1331 0.2238
Plasmodium falciparum tubulin beta chain 0.0052 0.034 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0022 0.0028
Giardia lamblia Gamma tubulin 0.002 0.0101 0.2648
Echinococcus multilocularis tubulin subunit beta 0.0052 0.034 0.0562
Echinococcus multilocularis tumor protein p63 0.0329 0.24 0.4045
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0815 0.1582
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0012 0.0035 0.0053
Leishmania major alpha tubulin 0.002 0.0101 0.2648
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0352 0.0582
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0022 0.0024
Brugia malayi alpha-tubulin 0.002 0.0101 0.0183
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0869 0.1457
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0093 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0022 0.0028
Loa Loa (eye worm) tubulin alpha-2 chain 0.002 0.0101 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0044 0.0367
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0028
Echinococcus granulosus tubulin alpha 1C chain 0.002 0.0101 0.0157
Loa Loa (eye worm) hypothetical protein 0.0009 0.0015 0.0014
Schistosoma mansoni alpha tubulin 0.002 0.0101 0.0157
Echinococcus multilocularis neuropeptide receptor A26 0.0459 0.3373 0.569
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0022 0.0028
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.03 0.0493
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0022 0.0024
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0022 0.0024
Onchocerca volvulus 0.001 0.0022 0.0019
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0093 0.2387
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0022 0.0024
Trichomonas vaginalis tubulin epsilon chain, putative 0.0052 0.034 0.2836
Trichomonas vaginalis tubulin gamma chain, putative 0.002 0.0101 0.0843
Leishmania major gamma-tubulin 0.002 0.0101 0.2648
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0172 0.1234 0.2404
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0694 0.1344
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0044 0.0367
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0024
Schistosoma mansoni topbp1 0.001 0.002 0.0021
Schistosoma mansoni DNA helicase recq5 0.0019 0.0093 0.0143
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0869 0.1457
Schistosoma mansoni thyroid hormone receptor 0.001 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0146 0.1038 0.2019
Trichomonas vaginalis tubulin alpha chain, putative 0.002 0.0101 0.0843
Schistosoma mansoni DNA helicase recq1 0.0019 0.0093 0.0143
Leishmania major beta tubulin 0.0052 0.034 1
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.03 0.0493
Loa Loa (eye worm) hypothetical protein 0.0079 0.054 0.1042
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0093 0.2283
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0022 0.0019
Echinococcus multilocularis tubulin delta chain 0.0009 0.0015 0.0012
Echinococcus granulosus GPCR family 2 0.0046 0.0294 0.0483
Loa Loa (eye worm) tubulin beta chain 0.0052 0.034 0.0651
Echinococcus granulosus alpha tubulin 0.002 0.0101 0.0157
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0321 0.9424
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.002 0.0165
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0028
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0077 0.0135
Brugia malayi Intermediate filament tail domain containing protein 0.0079 0.054 0.1042
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1347 1 1
Echinococcus granulosus tubulin subunit TubB 0.002 0.0101 0.0157
Loa Loa (eye worm) TAR-binding protein 0.0123 0.0869 0.1689
Trypanosoma brucei alpha tubulin 0.002 0.0101 0.2648
Giardia lamblia Alpha-tubulin 0.002 0.0101 0.2648
Trichomonas vaginalis conserved hypothetical protein 0.001 0.002 0.017
Echinococcus multilocularis tubulin epsilon chain 0.002 0.0101 0.0157
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0079 0.012
Echinococcus multilocularis GPCR, family 2 0.0046 0.0294 0.0483
Echinococcus granulosus microtubule associated protein 2 0.067 0.495 0.8358
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.002 0.0101 0.1182
Leishmania major beta tubulin 0.0052 0.034 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0294 0.0483
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0093 0.2387
Brugia malayi nuclear hormone receptor 0.001 0.0022 0.0028
Schistosoma mansoni microtubule-associated protein tau 0.067 0.495 0.8358
Trichomonas vaginalis tubulin, putative 0.0012 0.0035 0.0293
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0101 0.0843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0133 0.0942 0.1579
Echinococcus granulosus neuropeptide s receptor 0.0459 0.3373 0.569
Schistosoma mansoni tubulin subunit beta 0.0052 0.034 0.0562
Brugia malayi DKFZp564C0469 protein 0.001 0.002 0.0024
Echinococcus multilocularis tubulin alpha 1C chain 0.002 0.0101 0.0157
Brugia malayi Tubulin alpha chain 0.0009 0.0015 0.0014
Leishmania major epsilon tubulin, putative 0.002 0.0101 0.2648
Echinococcus multilocularis tubulin alpha chain 0.002 0.0101 0.0157
Echinococcus granulosus peroxisome assembly protein 26 0.002 0.0101 0.0157
Echinococcus granulosus Tubulin alpha 1 chain 0.002 0.0101 0.0157
Echinococcus multilocularis Tubulin beta 2C chain 0.0052 0.034 0.0562
Schistosoma mansoni lipoxygenase 0.0054 0.0352 0.0582
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0022 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0022 0.0028
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0321 0.053
Echinococcus multilocularis tubulin alpha chain 0.002 0.0101 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0046 0.0294 0.056
Brugia malayi topoisomerase 0.001 0.002 0.0024
Echinococcus granulosus replication factor c subunit 1 0.001 0.002 0.0021
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.002 0.017
Treponema pallidum DNA ligase (lig) 0.001 0.002 0.7493
Brugia malayi hypothetical protein 0.001 0.002 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.001 0.002 0.017
Brugia malayi tubulin alpha chain - mouse 0.002 0.0101 0.0183
Brugia malayi tubulin alpha-2 chain 0.002 0.0101 0.0183
Loa Loa (eye worm) hypothetical protein 0.0019 0.0093 0.0167
Trypanosoma cruzi alpha tubulin, putative 0.002 0.0101 0.2648
Trichomonas vaginalis tubulin epsilon chain, putative 0.002 0.0101 0.0843
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0093 0.0166
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0093 0.0166
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0024
Brugia malayi hypothetical protein 0.001 0.002 0.0024
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0022 0.0024
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.03 0.0493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0022 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0133 0.0942 0.1579
Echinococcus granulosus tubulin alpha chain 0.002 0.0101 0.0157
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0079 0.012
Brugia malayi Calcitonin receptor-like protein seb-1 0.0146 0.1038 0.2019
Echinococcus granulosus cpg binding protein 0.0059 0.0392 0.065
Echinococcus multilocularis Tubulin beta 2C chain 0.0052 0.034 0.0562
Loa Loa (eye worm) hypothetical protein 0.0078 0.0529 0.1021
Schistosoma mansoni tubulin subunit beta 0.0052 0.034 0.0562
Brugia malayi nuclear receptor NHR-88 0.001 0.0022 0.0028
Loa Loa (eye worm) tubulin beta chain 0.0009 0.0015 0.0014
Brugia malayi Tubulin beta chain 0.0009 0.0015 0.0014
Schistosoma mansoni loxhd1 0.0019 0.0093 0.0144
Onchocerca volvulus Huntingtin homolog 0.0121 0.085 0.8454
Brugia malayi hypothetical protein 0.0019 0.0093 0.0167
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0093 0.2387
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0028
Loa Loa (eye worm) RNA binding protein 0.0123 0.0869 0.1689
Toxoplasma gondii alpha tubulin TUBA1 0.002 0.0101 0.1182
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0093 0.2387
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0321 0.053
Echinococcus granulosus intermediate filament protein 0.0079 0.054 0.0899
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0022 0.0098
Mycobacterium ulcerans transcriptional regulator 0.1347 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0022 0.0024
Echinococcus granulosus RUN 0.0019 0.0093 0.0144
Loa Loa (eye worm) tubulin alpha chain 0.002 0.0101 0.0183
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0294 0.0483
Schistosoma mansoni polycystin 1-related 0.0019 0.0093 0.0144
Loa Loa (eye worm) tubulin beta-2A chain 0.0052 0.034 0.0651
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0093 0.0773
Schistosoma mansoni hypothetical protein 0.0286 0.2081 0.3506
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0024
Loa Loa (eye worm) alpha-tubulin 0.002 0.0101 0.0183
Plasmodium falciparum alpha tubulin 1 0.002 0.0101 0.2648
Echinococcus multilocularis Tubulin beta 2C chain 0.0052 0.034 0.0562
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0321 0.053
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0022 0.0024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0234 0.0443
Giardia lamblia Alpha-tubulin 0.002 0.0101 0.2648
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.03 0.2847
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0028
Echinococcus granulosus tubulin subunit beta 0.0052 0.034 0.0562
Trichomonas vaginalis tubulin alpha chain, putative 0.0012 0.0035 0.0293
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0022 0.0024
Trypanosoma brucei epsilon tubulin 0.002 0.0101 0.2648
Loa Loa (eye worm) hypothetical protein 0.0172 0.1234 0.2404
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.002 0.017
Schistosoma mansoni tubulin subunit gamma 0.002 0.0101 0.0157
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.03 0.0493
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.5831 0.9848
Leishmania major beta tubulin 0.0052 0.034 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0022 0.0028
Loa Loa (eye worm) BEN-1 protein 0.0052 0.034 0.0651
Schistosoma mansoni nuclear hormone receptor 0.001 0.0022 0.0024
Echinococcus granulosus tubulin alpha chain 0.002 0.0101 0.0157
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.0422
Trypanosoma brucei beta tubulin 0.0052 0.034 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.03 0.0572
Brugia malayi hypothetical protein 0.0035 0.0209 0.0394
Onchocerca volvulus Huntingtin homolog 0.0121 0.085 0.8454
Echinococcus granulosus beta tubulin 0.0052 0.034 0.0562
Leishmania major alpha tubulin 0.002 0.0101 0.2648
Loa Loa (eye worm) hypothetical protein 0.01 0.0694 0.1344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0133 0.0942 0.1579
Leishmania major beta tubulin 0.0052 0.034 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0022 0.0028
Echinococcus granulosus lamin dm0 0.0079 0.054 0.0899
Onchocerca volvulus 0.0079 0.054 0.5293
Echinococcus granulosus neuropeptide receptor A26 0.0459 0.3373 0.569
Loa Loa (eye worm) hypothetical protein 0.0692 0.5109 1
Schistosoma mansoni cpg binding protein 0.0059 0.0392 0.065
Trichomonas vaginalis tubulin, putative 0.0012 0.0035 0.0293
Echinococcus granulosus tubulin epsilon chain 0.002 0.0101 0.0157
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0093 0.0143
Entamoeba histolytica tubulin family protein 0.0052 0.034 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0133 0.0942 0.183
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0348 0.0576
Loa Loa (eye worm) tubulin alpha chain 0.002 0.0101 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0022 0.0028
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0321 0.9424
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0133 0.0942 0.1579
Brugia malayi cytoplasmic intermediate filament protein 0.0042 0.0266 0.0505
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.03 0.0493
Leishmania major alpha tubulin 0.002 0.0101 0.2648
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0022 0.0028
Schistosoma mansoni tubulin subunit beta 0.0052 0.034 0.0562
Echinococcus multilocularis beta tubulin 0.0052 0.034 0.0562
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0294 0.0483
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0348 0.0576
Onchocerca volvulus 0.0141 0.1002 1
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0024
Toxoplasma gondii beta-tubulin, putative 0.0052 0.034 0.4462
Echinococcus multilocularis beta tubulin 0.0052 0.034 0.0562
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0093 0.2401
Schistosoma mansoni hypothetical protein 0.0141 0.1002 0.168
Echinococcus granulosus tar DNA binding protein 0.0123 0.0869 0.1457
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0022 0.0024
Echinococcus multilocularis tubulin alpha 3 chain 0.002 0.0101 0.0157
Echinococcus multilocularis lamin 0.0079 0.054 0.0899
Brugia malayi RNA recognition motif domain containing protein 0.0123 0.0869 0.1689
Trypanosoma brucei tubulin gamma chain 0.002 0.0101 0.2648
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0022 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0022 0.0028
Entamoeba histolytica hypothetical protein 0.0035 0.0209 0.5908
Plasmodium falciparum tubulin gamma chain 0.002 0.0101 0.2648
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0042 0.0266 0.0505
Loa Loa (eye worm) alpha-tubulin 0.002 0.0101 0.0183
Loa Loa (eye worm) intermediate filament protein 0.0079 0.054 0.1042
Leishmania major alpha tubulin 0.002 0.0101 0.2648
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.002 0.0005
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0093 0.0143
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0093 0.2401
Echinococcus multilocularis tubulin alpha 1C chain 0.002 0.0101 0.0157
Schistosoma mansoni coup transcription factor 0.001 0.0022 0.0024
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0093 0.0144
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0022 0.0028
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0022 0.0024
Onchocerca volvulus 0.0019 0.0093 0.0741
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0044 0.0367
Entamoeba histolytica hypothetical protein 0.0035 0.0209 0.5908
Echinococcus granulosus tubulin alpha 3 chain 0.002 0.0101 0.0157
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0044 0.0367
Trypanosoma brucei alpha tubulin, putative 0.0012 0.0035 0.0616
Trypanosoma brucei protein kinase, putative 0.005 0.0321 0.9424
Trichomonas vaginalis helicase, putative 0.0013 0.0044 0.0367
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0101 0.0843
Brugia malayi MAP kinase sur-1 0.005 0.0321 0.0614
Leishmania major beta tubulin 0.0052 0.034 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0209 0.034
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0093 0.0144
Echinococcus multilocularis tubulin alpha chain 0.002 0.0101 0.0157
Echinococcus granulosus Tubulin alpha 1 chain 0.002 0.0101 0.0157
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.002 0.0165
Leishmania major beta tubulin 0.0052 0.034 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0052 0.034 0.0562
Echinococcus multilocularis tubulin alpha 0.002 0.0101 0.0157
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0093 0.0773
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0028
Brugia malayi Tubulin gamma chain 0.002 0.0101 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0022 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0321 0.268
Trypanosoma cruzi beta tubulin, putative 0.0052 0.034 1
Leishmania major beta tubulin 0.0052 0.034 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0022 0.0024
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0053 0.0076
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0146 0.1038 0.2019
Echinococcus multilocularis peroxisome assembly protein 26 0.002 0.0101 0.0157
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0022 0.0028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0223 0.0422
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0079 0.0139
Brugia malayi mbt repeat family protein 0.0047 0.03 0.0572
Schistosoma mansoni tubulin subunit alpha 0.002 0.0101 0.0157
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0348 0.0576
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0053 0.0076
Schistosoma mansoni tubulin subunit alpha 0.002 0.0101 0.0157
Loa Loa (eye worm) RecQ helicase 0.0019 0.0093 0.0166
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0093 0.0144
Echinococcus multilocularis Tubulin alpha 1 chain 0.002 0.0101 0.0157
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0093 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0168 0.1199 1
Trypanosoma brucei beta tubulin 0.0052 0.034 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0015 0.0126
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0022 0.0028
Echinococcus granulosus Tubulin beta 2C chain 0.0052 0.034 0.0562
Loa Loa (eye worm) hypothetical protein 0.002 0.0101 0.0183
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0053 0.0076
Plasmodium vivax tubulin alpha chain, putative 0.002 0.0101 0.2648
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0093 0.0143
Schistosoma mansoni tubulin subunit beta 0.0052 0.034 0.0562
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0321 0.053
Onchocerca volvulus 0.0056 0.0368 0.3546
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.002 0.017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0044 0.0367
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0294 0.056
Schistosoma mansoni hypothetical protein 0.0019 0.0093 0.0144
Echinococcus granulosus tubulin alpha 3 chain 0.002 0.0101 0.0157
Echinococcus multilocularis tubulin subunit TubB 0.002 0.0101 0.0157
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.002 0.0021
Plasmodium vivax tubulin alpha chain, putative 0.002 0.0101 0.2648
Echinococcus granulosus Tubulin beta 2C chain 0.0052 0.034 0.0562
Brugia malayi Tubulin alpha-2 chain 0.002 0.0101 0.0183
Trichomonas vaginalis tubulin, putative 0.0009 0.0015 0.0126
Brugia malayi hypothetical protein 0.0692 0.5109 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.0367
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0093 0.2387
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0022 0.0028
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.002 0.0101 0.0843
Echinococcus granulosus tubulin beta 4A class IVa 0.0052 0.034 0.0562
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0022 0.0024
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0009 0.0015 0.0126
Echinococcus granulosus beta tubulin 0.0052 0.034 0.0562
Loa Loa (eye worm) hypothetical protein 0.0048 0.0308 0.0588
Trichomonas vaginalis tubulin alpha chain, putative 0.0012 0.0035 0.0293
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0308 0.0507
Trichomonas vaginalis tubulin gamma chain, putative 0.0009 0.0015 0.0126
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0352 0.0582
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0028
Echinococcus granulosus nibrin 0.001 0.002 0.0021
Loa Loa (eye worm) tubulin alpha-3 chain 0.0009 0.0015 0.0014
Echinococcus multilocularis neuropeptide s receptor 0.0459 0.3373 0.569
Entamoeba histolytica hypothetical protein 0.0035 0.0209 0.5908
Trichomonas vaginalis conserved hypothetical protein 0.001 0.002 0.017
Trypanosoma cruzi epsilon tubulin, putative 0.002 0.0101 0.2648
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0009 0.0015 0.0126
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0133 0.0942 0.1579
Plasmodium vivax tubulin epsilon chain, putative 0.002 0.0101 0.2648
Trypanosoma brucei alpha tubulin 0.002 0.0101 0.2648
Brugia malayi hypothetical protein 0.0019 0.0093 0.0167
Toxoplasma gondii alpha-tubulin I, putative 0.002 0.0101 0.1182
Trichomonas vaginalis tubulin epsilon chain, putative 0.002 0.0101 0.0843
Brugia malayi Tubulin beta-1 chain 0.0052 0.034 0.0651
Toxoplasma gondii beta tubulin 0.0052 0.034 0.4462
Leishmania major beta tubulin 0.0052 0.034 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0022 0.0024
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0209 0.034
Schistosoma mansoni intermediate filament proteins 0.0079 0.054 0.0899
Echinococcus granulosus FTZ F1 alpha 0.001 0.0022 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0044 0.0367
Echinococcus granulosus tubulin beta 1 chain 0.0052 0.034 0.0562
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0815 0.1582
Onchocerca volvulus 0.0012 0.0035 0.0149
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.1331 0.2238
Schistosoma mansoni hypothetical protein 0.0035 0.0209 0.034
Entamoeba histolytica tubulin alpha chain, putative 0.002 0.0101 0.2548
Brugia malayi Doublecortin family protein 0.0019 0.0093 0.0167
Trichomonas vaginalis tubulin alpha chain, putative 0.0012 0.0035 0.0293
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0869 0.1457
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0101 0.0843
Trichomonas vaginalis tubulin gamma chain, putative 0.0052 0.034 0.2836
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.002 0.0165
Schistosoma mansoni tubulin subunit beta 0.0052 0.034 0.0562
Trypanosoma cruzi tubulin gamma chain 0.002 0.0101 0.2648
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0133 0.0942 0.1579
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0012 0.0035 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0044 0.0367
Trichomonas vaginalis tubulin epsilon chain, putative 0.0052 0.034 0.2836
Brugia malayi Cell division protein ftsZ 0.0009 0.0015 0.0014
Trichomonas vaginalis tubulin gamma chain, putative 0.002 0.0101 0.0843
Plasmodium falciparum tubulin epsilon chain, putative 0.002 0.0101 0.2648
Brugia malayi MH2 domain containing protein 0.0116 0.0815 0.1582
Echinococcus granulosus Tubulin alpha 1 chain 0.002 0.0101 0.0157
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.03 0.0572
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0321 0.053
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0321 0.4205
Echinococcus multilocularis tubulin alpha 3 chain 0.002 0.0101 0.0157
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.002 0.0074
Schistosoma mansoni hypothetical protein 0.01 0.0694 0.1159
Entamoeba histolytica hypothetical protein 0.001 0.002 0.0031
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0009 0.0002
Brugia malayi beta-tubulin, identical 0.0052 0.034 0.0651
Echinococcus multilocularis hypothetical protein 0.002 0.0101 0.0157
Leishmania major alpha tubulin 0.002 0.0101 0.2648
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.002 0.0165
Schistosoma mansoni tubulin subunit alpha 0.002 0.0101 0.0157
Echinococcus granulosus dnaJ subfamily B 0.08 0.5921 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0093 0.1065
Schistosoma mansoni hypothetical protein 0.0046 0.0294 0.0483
Trichomonas vaginalis conserved hypothetical protein 0.001 0.002 0.017
Echinococcus multilocularis cpg binding protein 0.0059 0.0392 0.065
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0022 1
Echinococcus granulosus Tubulin beta 2C chain 0.0052 0.034 0.0562
Loa Loa (eye worm) tubulin gamma chain 0.002 0.0101 0.0183
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0022 0.0028
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0348 0.0667
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.000000000059221 0.00000000049383
Loa Loa (eye worm) beta-tubulin 0.0052 0.034 0.0651
Schistosoma mansoni tar DNA-binding protein 0.0123 0.0869 0.1457
Echinococcus multilocularis tar DNA binding protein 0.0123 0.0869 0.1457
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0321 0.0614
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0093 0.0144
Loa Loa (eye worm) hypothetical protein 0.0121 0.085 0.165
Trypanosoma brucei beta tubulin 0.0052 0.034 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0022 0.0028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0022 0.0028
Entamoeba histolytica tubulin family protein 0.0052 0.034 1
Chlamydia trachomatis DNA ligase 0.001 0.002 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.0367
Echinococcus multilocularis Tubulin alpha 1 chain 0.002 0.0101 0.0157
Onchocerca volvulus 0.0047 0.03 0.2847
Echinococcus granulosus tubulin alpha 0.002 0.0101 0.0157
Schistosoma mansoni cpg binding protein 0.0059 0.0392 0.065
Schistosoma mansoni blooms syndrome DNA helicase 0.0009 0.0019 0.0019
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0093 0.1065
Entamoeba histolytica recQ family DNA helicase 0.001 0.0022 0.0087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.0367
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0368 0.0706
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0028
Schistosoma mansoni DNA ligase IV 0.001 0.002 0.0021
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.002 0.0005
Giardia lamblia Replication factor C, subunit 1 0.001 0.002 0.0165
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0022 0.0024
Onchocerca volvulus 0.0048 0.0308 0.2928
Mycobacterium ulcerans TetR family transcriptional regulator 0.1347 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0146 0.1038 0.2019
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0101 0.0843
Loa Loa (eye worm) hypothetical protein 0.0121 0.085 0.165
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0141 0.1002 0.1948
Leishmania major alpha tubulin 0.002 0.0101 0.2648
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0123 0.0869 0.1689
Entamoeba histolytica tubulin gamma chain 0.002 0.0101 0.2548
Echinococcus multilocularis tubulin alpha chain 0.002 0.0101 0.0157
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0294 0.056
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.0838 0.1404
Brugia malayi Tubulin alpha-2 chain 0.002 0.0101 0.0183
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0053 0.0076
Echinococcus granulosus survival motor neuron protein 1 0.0692 0.5109 0.8628
Trichomonas vaginalis tubulin beta chain, putative 0.0052 0.034 0.2836
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0022 0.0028
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0009 0.0019 0.0135
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0022 0.0024
Trichomonas vaginalis tubulin beta chain, putative 0.0012 0.0035 0.0293
Echinococcus multilocularis nibrin 0.001 0.002 0.0021
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0093 0.0143
Echinococcus granulosus tubulin alpha chain 0.002 0.0101 0.0157
Schistosoma mansoni topbp1 0.001 0.002 0.0021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0093 0.0166
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.002 0.0165
Brugia malayi CXXC zinc finger family protein 0.0056 0.0368 0.0706
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0321 0.268
Schistosoma mansoni tubulin subunit delta 0.0009 0.0015 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0022 0.0024
Brugia malayi mbt repeat family protein 0.0047 0.03 0.0572
Echinococcus multilocularis RUN 0.0019 0.0093 0.0144
Giardia lamblia Beta tubulin 0.0052 0.034 1
Brugia malayi ecdysteroid receptor 0.001 0.0022 0.0028
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0321 0.9424
Echinococcus multilocularis Tubulin beta 2C chain 0.0052 0.034 0.0562
Loa Loa (eye worm) hypothetical protein 0.0019 0.0093 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0022 0.0028
Leishmania major beta tubulin 0.0052 0.034 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.03 0.0493
Brugia malayi RNA binding protein 0.0123 0.0869 0.1689
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0321 0.9424
Echinococcus granulosus tubulin delta chain 0.0009 0.0015 0.0012
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0101 0.0843
Echinococcus granulosus Tubulin beta 2C chain 0.0052 0.034 0.0562
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0022 0.022
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0038 0.0234 0.0382
Giardia lamblia Beta tubulin 0.0052 0.034 1
Trichomonas vaginalis tubulin beta chain, putative 0.002 0.0101 0.0843
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0022 0.0024
Loa Loa (eye worm) MBCTL1 0.0054 0.0348 0.0667
Trypanosoma brucei beta tubulin 0.002 0.0101 0.2648
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0348 0.0576
Leishmania major alpha tubulin 0.002 0.0101 0.2648
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0321 0.268
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0022 0.0019
Schistosoma mansoni tubulin subunit epsilon 0.002 0.0101 0.0157
Loa Loa (eye worm) hypothetical protein 0.001 0.0022 0.0028
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0019 0.006
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0022 0.0024
Echinococcus granulosus Tubulin beta 2C chain 0.0052 0.034 0.0562
Echinococcus multilocularis Tubulin alpha 1 chain 0.002 0.0101 0.0157
Entamoeba histolytica tubulin alpha-1 chain 0.002 0.0101 0.2548
Loa Loa (eye worm) tubulin alpha 2 0.0012 0.0035 0.0053
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.002 0.0165
Echinococcus multilocularis lamin dm0 0.0079 0.054 0.0899
Plasmodium vivax tubulin gamma chain, putative 0.002 0.0101 0.2648
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0133 0.0942 0.183
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0022 0.0024
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.002 0.0024
Brugia malayi steroid hormone receptor 0.001 0.0022 0.0028
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0294 0.0483
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0093 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0015 0.0126
Leishmania major beta tubulin 0.0052 0.034 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0022 0.0028
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.002 0.017
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0321 0.9424
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0044 0.0367
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0024
Leishmania major beta tubulin 0.0052 0.034 1
Brugia malayi follicle stimulating hormone receptor 0.0457 0.3362 0.6575
Trypanosoma brucei epsilon tubulin 0.002 0.0101 0.2648
Schistosoma mansoni cpg binding protein 0.0056 0.0368 0.0609
Echinococcus granulosus tubulin alpha chain 0.002 0.0101 0.0157
Entamoeba histolytica hypothetical protein 0.0035 0.0209 0.5908
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0038 0.0234 0.0382
Schistosoma mansoni tubulin subunit alpha 0.0009 0.0015 0.0012
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.03 0.0493
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0209 0.034
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.0743 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0052 0.034 0.2836
Toxoplasma gondii ATPase, AAA family protein 0.001 0.002 0.0074
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0093 0.0166
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0093 0.0144
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0022 0.0024
Leishmania major beta tubulin 0.0052 0.034 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0348 0.0576
Echinococcus multilocularis replication factor c subunit 1 0.001 0.002 0.0021
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0321 0.9424
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0044 0.0367
Echinococcus granulosus bloom syndrome protein 0.0019 0.0093 0.0143
Schistosoma mansoni rab6-interacting 0.0019 0.0093 0.0144
Schistosoma mansoni rab6-interacting 0.0019 0.0093 0.0144
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0012 0.0035 0.0293
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0457 0.3362 0.6575
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.002 0.0165
Leishmania major alpha tubulin 0.002 0.0101 0.2648
Trichomonas vaginalis tubulin epsilon chain, putative 0.0009 0.0015 0.0126
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0321 0.9424
Leishmania major beta tubulin 0.0052 0.034 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 41 nM Maximum percent inhibition of electrically stimulated twitch in guinea pig ileal longitudinal muscle(GPI) preparation ChEMBL. 2475628
Ke (functional) = 28 nM Antagonistic activity against morphine in guinea pig ileal longitudinal muscle(GPI) preparation ChEMBL. 2475628

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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