Detailed information for compound 1054356

Basic information

Technical information
  • TDR Targets ID: 1054356
  • Name: N'-[3-(3-ethylaminopropylamino)propyl]-N-(3-m ethylbutyl)propane-1,3-diamine
  • MW: 286.5 | Formula: C16H38N4
  • H donors: 4 H acceptors: 0 LogP: 1.63 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNCCCNCCCNCCCNCCC(C)C
  • InChi: 1S/C16H38N4/c1-4-17-9-5-10-18-11-6-12-19-13-7-14-20-15-8-16(2)3/h16-20H,4-15H2,1-3H3
  • InChiKey: IOCSGUKDVIEBBL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-[3-(3-ethylaminopropylamino)propyl]-N-isopentyl-propane-1,3-diamine
  • N'-[3-(3-ethylaminopropylamino)propyl]-N-isopentylpropane-1,3-diamine
  • 3-[3-(3-ethylaminopropylamino)propylamino]propyl-isoamyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0011 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0034 0.0095
Brugia malayi steroid hormone receptor 0.0028 0.0011 0.0033
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0033
Schistosoma mansoni alpha glucosidase 0.0162 0.0283 0.0283
Giardia lamblia Fructose-bisphosphate aldolase 0.0308 0.058 1
Loa Loa (eye worm) hypothetical protein 0.019 0.0339 0.1098
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0038 0.1109
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0011 0.0033
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0095 0.0095
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.011 0.0178 0.0506
Echinococcus multilocularis microtubule associated protein 2 0.4946 1 1
Echinococcus multilocularis lamin 0.0056 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.0044
Trichomonas vaginalis chromobox protein, putative 0.0101 0.016 0.0455
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0038 0.0038
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.0339 0.0963
Loa Loa (eye worm) hypothetical protein 0.019 0.0339 0.1098
Schistosoma mansoni transcription factor btf3 0.0037 0.0029 0.0028
Brugia malayi hypothetical protein 0.0465 0.0899 0.2912
Brugia malayi nuclear receptor NHR-88 0.0028 0.0011 0.0033
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0034 0.0033
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.058 0.9825
Echinococcus multilocularis lysine specific demethylase 6a 0.0031 0.0017 0.0017
Echinococcus multilocularis dna polymerase eta 0.0029 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0184 0.0328 0.0328
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0028 0.0078
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0009 0.0009
Plasmodium vivax hypothetical protein, conserved 0.019 0.0339 0.8389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.005 0.0141
Brugia malayi Alpha-L-fucosidase family protein 0.0776 0.153 0.4957
Schistosoma mansoni phosphatidylserine receptor 0.0031 0.0017 0.0017
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0155 0.0269 0.0268
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0505 0.1435
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0058 0.0239
Loa Loa (eye worm) heterochromatin protein 1 0.016 0.028 0.0906
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0348 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.005 0.0141
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0029 0.0092
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0095 0.279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.003 0.0085
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.005 0.0841
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.019 0.0339 0.1404
Entamoeba histolytica hypothetical protein 0.0037 0.0029 0.048
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0041 0.0169
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.005 0.005
Brugia malayi PXA domain containing protein 0.0039 0.0034 0.0108
Leishmania major hypothetical protein, conserved 0.0031 0.0017 0.05
Giardia lamblia DINP protein human, muc B family 0.0043 0.0041 0.0059
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.0101 0.0101
Trypanosoma cruzi ISWI complex protein 0.0066 0.0088 0.2589
Giardia lamblia GTOR 0.0047 0.005 0.0222
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0033
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0034 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0041 0.0114
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0335 0.0951
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0295 0.0554 0.0553
Echinococcus multilocularis lysine specific demethylase 5A 0.0117 0.0191 0.0191
Schistosoma mansoni inositol monophosphatase 0.0036 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.003 0.0085
Mycobacterium tuberculosis Conserved protein 0.019 0.0339 0.1404
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0101 0.016 0.0455
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0034 0.0033
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0034 0.0033
Loa Loa (eye worm) jmjC domain-containing protein 0.0126 0.0211 0.0683
Echinococcus granulosus jumonji domain containing 1A 0.0031 0.0017 0.0017
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0029 0.0836
Loa Loa (eye worm) inositol-1 0.0036 0.0027 0.0087
Echinococcus granulosus lamin 0.0056 0.0068 0.0068
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0061 0.1791
Echinococcus granulosus fetal alzheimer antigen falz 0.0099 0.0155 0.0154
Echinococcus multilocularis expressed conserved protein 0.0044 0.0044 0.0043
Brugia malayi jmjC domain containing protein 0.0316 0.0595 0.1928
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0222 0.0404 0.0404
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0095 0.279
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0011 0.001
Mycobacterium ulcerans hypothetical protein 0.019 0.0339 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0026 0.0071
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0027 0.0076
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.0283 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0006 0.0015
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0184 0.5424
Onchocerca volvulus 0.0035 0.0026 0.0073
Onchocerca volvulus Glucosylceramidase homolog 0.0178 0.0316 0.0896
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0027 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0036 0.0028 0.0027
Echinococcus multilocularis Protein lozenge 0.0058 0.0073 0.0072
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0027 0.0076
Echinococcus granulosus Chromobox protein 3 0.0036 0.0028 0.0027
Echinococcus granulosus chromobox protein 2 0.0036 0.0028 0.0027
Schistosoma mansoni lamin 0.0056 0.0068 0.0068
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0011 0.001
Trypanosoma cruzi ISWI complex protein 0.0066 0.0088 0.2589
Loa Loa (eye worm) jmjC domain-containing protein 0.0199 0.0358 0.116
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0038 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0011 0.0031
Echinococcus granulosus dna polymerase kappa 0.0083 0.0124 0.0123
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0017 0.0055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0028 0.0078
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.0339 0.0339
Brugia malayi jmjC domain containing protein 0.0031 0.0017 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0104 0.0406
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0055 0.0226
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0184 0.0761
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0064 0.187
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0011 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0124 0.3639
Echinococcus multilocularis lysosomal alpha glucosidase 0.0987 0.196 0.1959
Brugia malayi F/Y-rich N-terminus family protein 0.0056 0.0069 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0028 0.0078
Trypanosoma brucei unspecified product 0.007 0.0097 0.2835
Trypanosoma brucei DNA polymerase IV, putative 0.0083 0.0124 0.3639
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0038 0.1109
Loa Loa (eye worm) hypothetical protein 0.0036 0.0028 0.0089
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0051 0.0165
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.005 0.1464
Loa Loa (eye worm) hypothetical protein 0.0096 0.015 0.0485
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0034 0.0033
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0316 0.0595 0.0595
Echinococcus multilocularis beta LACTamase domain containing family member 0.019 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0036 0.0028 0.0089
Trichomonas vaginalis alpha-glucosidase, putative 0.0162 0.0283 0.0803
Echinococcus granulosus PHD finger protein rhinoceros 0.0096 0.015 0.015
Schistosoma mansoni alpha-glucosidase 0.0936 0.1855 0.1855
Brugia malayi Kringle domain containing protein 0.0054 0.0064 0.0205
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0011 0.0033
Echinococcus multilocularis sphingosine kinase 1 0.0313 0.059 0.0589
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.0101 0.0394
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0011 0.001
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0078 0.0113 0.1907
Leishmania major trypanothione reductase 0.005 0.0055 0.1611
Plasmodium falciparum thioredoxin reductase 0.005 0.0055 0.3652
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.058 0.1646
Brugia malayi PHD-finger family protein 0.0109 0.0176 0.0568
Schistosoma mansoni zinc finger protein 0.0086 0.0129 0.0128
Mycobacterium leprae Probable lipase LipE 0.019 0.0339 1
Mycobacterium ulcerans esterase/lipase LipP 0.019 0.0339 0.1324
Schistosoma mansoni methyl-cpg binding protein mbd 0.0074 0.0104 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.009 0.2651
Entamoeba histolytica hypothetical protein 0.0036 0.0028 0.0465
Loa Loa (eye worm) hypothetical protein 0.0063 0.0083 0.0266
Loa Loa (eye worm) hypothetical protein 0.011 0.0178 0.0577
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0316 0.0896
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0104 0.3065
Brugia malayi beta-lactamase 0.019 0.0339 0.1098
Echinococcus granulosus transcription factor Dp 1 0.004 0.0036 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0009 0.0032
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.0206 0.0205
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0036 0.0028 0.0027
Schistosoma mansoni hypothetical protein 0.0395 0.0757 0.0756
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0029 0.1894
Trypanosoma brucei trypanothione reductase 0.005 0.0055 0.1611
Brugia malayi jmjC domain containing protein 0.0031 0.0017 0.0055
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.011 0.0178 0.0506
Brugia malayi Cytochrome P450 family protein 0.0052 0.006 0.0193
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0122
Echinococcus granulosus fucosidase alpha L 1 tissue 0.1283 0.256 0.2559
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0124 0.3639
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.002 0.0564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0026 0.0071
Schistosoma mansoni hypothetical protein 0.0054 0.0064 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0011 0.001
Echinococcus multilocularis chromobox protein 2 0.0036 0.0028 0.0027
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0308 0.058 0.9825
Treponema pallidum fructose-bisphosphate aldolase 0.0308 0.058 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0162 0.0283 0.0803
Mycobacterium tuberculosis Probable lipase LipD 0.019 0.0339 0.1404
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0041 0.0114
Echinococcus multilocularis tumor protein p63 0.1449 0.2897 0.2896
Brugia malayi RNA binding protein 0.0194 0.0348 0.1125
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0011 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0011 0.0033
Schistosoma mansoni sphingoid long chain base kinase 0.0313 0.059 0.0589
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.019 0.0339 0.1098
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0034 0.0033
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.019 0.0339 0.1404
Schistosoma mansoni sphingosine kinase A B 0.0313 0.059 0.0589
Echinococcus multilocularis beta adrenergic receptor kinase 0.0039 0.0034 0.0033
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0004 0.0242
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0095 0.0148 0.0477
Echinococcus granulosus beta-adrenergic receptor kinase 0.0039 0.0034 0.0033
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0095 0.0148 0.0418
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.0041 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0295 0.0554 0.0553
Loa Loa (eye worm) hypothetical protein 0.0465 0.0899 0.2912
Echinococcus granulosus phd:f box containing protein 0.0031 0.0017 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0505 0.1435
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0043 0.0041 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0011 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0124 0.3639
Trypanosoma cruzi hypothetical protein, conserved 0.0162 0.0283 0.8337
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0026 0.0631
Brugia malayi ImpB/MucB/SamB family protein 0.0029 0.0014 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0348 0.0347
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0104 0.043
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0072 0.0101 0.0101
Echinococcus multilocularis tissue type plasminogen activator 0.0054 0.0064 0.0063
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0067 0.1651
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0034 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0084 0.0327
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0 0.0012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0108
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0084 0.0347
Onchocerca volvulus 0.0035 0.0026 0.0073
Schistosoma mansoni cellular tumor antigen P53 0.0212 0.0385 0.0384
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0295 0.0554 0.0553
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.009 0.2651
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0011 0.001
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0004 0.0014
Onchocerca volvulus 0.0065 0.0087 0.0245
Mycobacterium ulcerans DNA polymerase IV 0.0083 0.0124 0.0482
Schistosoma mansoni jumonji domain containing protein 0.0251 0.0464 0.0463
Plasmodium falciparum glutathione reductase 0.005 0.0055 0.3652
Echinococcus granulosus tar DNA binding protein 0.0194 0.0348 0.0347
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0505 0.1435
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.058 0.1646
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0184 0.0761
Leishmania major cathepsin L-like protease 0.0067 0.009 0.2651
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0036 0.0028 0.0089
Onchocerca volvulus 0.019 0.0339 0.0963
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0011 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0348 0.0347
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0124 0.3639
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0072 0.0101 0.0417
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.011 0.0178 0.525
Schistosoma mansoni alpha-glucosidase 0.0936 0.1855 0.1855
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0011 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0316 0.0896
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0009 0.0034
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0162 0.0283 0.4793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0016 0.0045
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0316 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0006 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0026 0.0071
Brugia malayi jmjC domain containing protein 0.0126 0.0211 0.0683
Plasmodium vivax glutathione reductase, putative 0.005 0.0055 0.1352
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0028 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0505 0.1435
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0034 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0124 0.3639
Schistosoma mansoni hypothetical protein 0.0356 0.0678 0.0678
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0038 0.0038
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0034 0.0033
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0074 0.0104 0.0103
Leishmania major DNA polymerase kappa, putative 0.0043 0.0041 0.1202
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0027 0.079
Echinococcus multilocularis peregrin 0.0107 0.0171 0.017
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0295 0.0554 0.1793
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.021 0.0868
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0074 0.0209
Brugia malayi Disco-interacting protein 2 homolog 0.0027 0.0009 0.0026
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0027 0.0454
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0104 0.1762
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0011 0.001
Onchocerca volvulus 0.0131 0.022 0.0623
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0068 0.022
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0029 0.0014 0.0014
Echinococcus multilocularis dna polymerase kappa 0.0083 0.0124 0.0123
Schistosoma mansoni hypothetical protein 0.0036 0.0028 0.0027
Schistosoma mansoni cpg binding protein 0.0038 0.0031 0.003
Echinococcus multilocularis phd:f box containing protein 0.0031 0.0017 0.0017
Brugia malayi jmjC domain containing protein 0.0031 0.0017 0.0055
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0099 0.0155 0.0154
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0035 0.0026 0.0083
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0078 0.0113 0.0364
Echinococcus granulosus dnaJ subfamily B 0.0395 0.0757 0.0756
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0017 0.0055
Onchocerca volvulus 0.0212 0.0385 0.1093
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0078 0.0113 0.7518
Schistosoma mansoni hypothetical protein 0.0102 0.0161 0.0161
Brugia malayi Thioredoxin reductase 0.005 0.0055 0.0177
Echinococcus multilocularis transcription factor btf3 0.0037 0.0029 0.0028
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.011 0.0178 0.525
Loa Loa (eye worm) hypothetical protein 0.0074 0.0104 0.0337
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0027 0.0009 0.0008
Echinococcus multilocularis jumonji domain containing 1A 0.0031 0.0017 0.0017
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0011 0.001
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.0028 0.0027
Echinococcus multilocularis Chromobox protein 3 0.0036 0.0028 0.0027
Brugia malayi Bromodomain containing protein 0.0165 0.029 0.0937
Loa Loa (eye worm) hypothetical protein 0.0074 0.0104 0.0337
Schistosoma mansoni chromobox protein 0.016 0.028 0.028
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0039 0.0034 0.0108
Schistosoma mansoni transcription factor LCR-F1 0.0184 0.0328 0.0328
Onchocerca volvulus 0.0056 0.0068 0.0193
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0078 0.0113 0.0112
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0011 0.001
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0104 0.0337
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0009 0.0239
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.058 0.1646
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0072 0.0101 0.0394
Loa Loa (eye worm) alpha-L-fucosidase 0.0776 0.153 0.4957
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.005 0.005
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0038 0.1109
Schistosoma mansoni alpha-l-fucosidase 0.0776 0.153 0.1529
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0031 0.0017 0.043
Brugia malayi PHD-finger family protein 0.0096 0.015 0.0485
Loa Loa (eye worm) glutathione reductase 0.005 0.0055 0.0177
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0108
Brugia malayi ecdysteroid receptor 0.0028 0.0011 0.0033
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.026 0.1074
Toxoplasma gondii propionate-CoA ligase 0.0023 0 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.058 0.1646
Trichomonas vaginalis alpha-L-fucosidase, putative 0.034 0.0645 0.1833
Onchocerca volvulus 0.0035 0.0026 0.0073
Entamoeba histolytica hypothetical protein, conserved 0.0313 0.059 1
Loa Loa (eye worm) PHD-finger family protein 0.0096 0.015 0.0485
Echinococcus granulosus jumonji domain containing protein 0.0134 0.0227 0.0226
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0505 0.1435
Echinococcus granulosus intermediate filament protein 0.0056 0.0068 0.0068
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0034 0.0108
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0104 0.0406
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0034 0.0108
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0027 0.0009 0.0239
Echinococcus granulosus tumor protein p63 0.1449 0.2897 0.2896
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0011 0.001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0038 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0074 0.0209
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0011 0.001
Echinococcus multilocularis disco interacting protein 2 0.0027 0.0009 0.0008
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0009 0.0034
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0162 0.0283 0.4793
Loa Loa (eye worm) transcription factor SMAD2 0.0245 0.0452 0.1463
Trichomonas vaginalis DNA polymerase eta, putative 0.0083 0.0124 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0006 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.009 0.009
Loa Loa (eye worm) PHD-finger family protein 0.0089 0.0135 0.0436
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0099 0.0155 0.0154
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0034 0.0033
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0009 0.0034
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0041 0.0037 0.0037
Onchocerca volvulus 0.0056 0.0068 0.0193
Loa Loa (eye worm) hypothetical protein 0.0036 0.0028 0.0089
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0095 0.279
Schistosoma mansoni hypothetical protein 0.0096 0.015 0.015
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.005 0.1464
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0058 0.0239
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0009 0.0239
Brugia malayi nuclear hormone receptor 0.0028 0.0011 0.0033
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0033 0.0022 0.1415
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0029 0.0836
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0029 0.008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0011 0.001
Echinococcus multilocularis lamin dm0 0.0056 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0108
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.4151 0.8385 0.8385
Onchocerca volvulus 0.0465 0.0899 0.2554
Trichomonas vaginalis alpha-glucosidase, putative 0.011 0.0178 0.0506
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0028 0.0689
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0011 0.001
Brugia malayi hypothetical protein 0.0039 0.0034 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0029 0.008
Loa Loa (eye worm) beta-lactamase 0.019 0.0339 0.1098
Mycobacterium ulcerans putative fatty-acid--CoA ligase 0.0027 0.0009 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0011 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0148 0.0418
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.0339 0.0963
Onchocerca volvulus 0.0035 0.0026 0.0073
Trichomonas vaginalis Heterochromatin protein, putative 0.0036 0.0028 0.0078
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0039 0.0034 0.0095
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0017 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0028 0.0078
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0031 0.0017 0.043
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0029 0.0836
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0015 0.0048
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0104 0.3065
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0095 0.279
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0039 0.0034 0.0108
Mycobacterium ulcerans alpha-L-fucosidase 0.1283 0.256 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0007 0.0022
Loa Loa (eye worm) hypothetical protein 0.0235 0.0431 0.1395
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0068 0.022
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0465 0.0899 0.2912
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0011 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0162 0.0283 0.8337
Loa Loa (eye worm) hypothetical protein 0.0026 0.0007 0.0022
Onchocerca volvulus 0.0039 0.0033 0.0092
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0031 0.0887
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0038 0.0107
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0104 0.1762
Brugia malayi Glycosyl hydrolases family 31 protein 0.011 0.0178 0.0577
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0035 0.0026 0.0083
Trichomonas vaginalis alpha-L-fucosidase, putative 0.034 0.0645 0.1833
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0029 0.008
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.0216
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.005 0.0161
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.019 0.0339 0.1098
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0078 0.0113 0.3317
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0084 0.0327
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0027 0.0009 0.0239
Onchocerca volvulus 0.0131 0.022 0.0623
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0028 0.0465
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.009 0.2651
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0034 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.005 0.0141
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0011 0.001
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0271 0.0505 0.1636
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0104 0.0337
Schistosoma mansoni phd/f-box containing protein 0.0031 0.0017 0.0017
Echinococcus multilocularis PHD finger protein rhinoceros 0.0096 0.015 0.015
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0078 0.0113 0.0364
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0104 0.0406
Echinococcus granulosus cpg binding protein 0.0038 0.0031 0.003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.009 0.2651
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0124 0.3639
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0034 0.0033
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0185 0.0331 0.1071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.005 0.005
Trichomonas vaginalis chromobox protein, putative 0.0101 0.016 0.0455
Loa Loa (eye worm) hypothetical protein 0.0131 0.022 0.071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.009 0.2651
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0184 0.0761
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.009 0.2651
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.005 0.1464
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0078 0.0113 0.0364
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0316 0.0595 0.0595
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.0257 0.0832
Brugia malayi hypothetical protein 0.0235 0.0431 0.1395
Brugia malayi CHD4 protein 0.0046 0.0048 0.0153
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0031 0.0887
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0987 0.196 0.6351
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0339 1
Brugia malayi hypothetical protein 0.0039 0.0034 0.0108
Brugia malayi Bromodomain containing protein 0.0107 0.0171 0.0552
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0029 0.0701
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0011 0.0033
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.0216
Mycobacterium ulcerans DNA polymerase IV 0.0083 0.0124 0.0482
Schistosoma mansoni cpg binding protein 0.0028 0.0011 0.001
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0041 0.1202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.009 0.2651
Loa Loa (eye worm) hypothetical protein 0.0056 0.0068 0.022
Toxoplasma gondii PHD-finger domain-containing protein 0.0096 0.015 0.3709
Mycobacterium tuberculosis Conserved protein 0.019 0.0339 0.1404
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0032 0.0018 0.0523
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0029 0.0014 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.0124 0.3639
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.005 0.0161
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0038 0.0038
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.003 0.0085
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0011 0.001
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0011 0.001
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0078 0.0113 0.2783
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0222 0.0404 0.0404
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.058 0.1646
Echinococcus multilocularis neutral alpha glucosidase AB 0.0162 0.0283 0.0283
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0083 0.2422
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.011 0.0178 0.3018
Echinococcus granulosus tissue type plasminogen activator 0.0054 0.0064 0.0063
Onchocerca volvulus 0.019 0.0339 0.0963
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.021 0.0868
Trichomonas vaginalis sucrase-isomaltase, putative 0.0162 0.0283 0.0803
Trichomonas vaginalis chromobox protein, putative 0.016 0.028 0.0795
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0034 0.0033
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0348 0.0347
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.009 0.2651
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0028 0.0678
Brugia malayi hypothetical protein 0.0131 0.022 0.071
Trypanosoma brucei glucosidase, putative 0.0162 0.0283 0.8337
Echinococcus multilocularis zinc finger protein 0.0086 0.0129 0.0128
Leishmania major cathepsin L-like protease 0.0067 0.009 0.2651
Echinococcus granulosus expressed conserved protein 0.0044 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0108
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.0216
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0009 0.0009
Echinococcus granulosus neutral alpha glucosidase AB 0.0162 0.0283 0.0283
Loa Loa (eye worm) CHromoDomain protein family member 0.0046 0.0048 0.0153
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0084 0.0084
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0038 0.0637
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0041 0.0114
Entamoeba histolytica hypothetical protein 0.0184 0.0328 0.5559
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0 0.0012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0011 0.001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0011 0.0033
Trichomonas vaginalis set domain proteins, putative 0.1754 0.3518 1
Brugia malayi ImpB/MucB/SamB family protein 0.0029 0.0014 0.0044
Schistosoma mansoni chromobox protein 0.016 0.028 0.028
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0004 0.0101
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0104 0.0337
Entamoeba histolytica hypothetical protein 0.0184 0.0328 0.5559
Loa Loa (eye worm) TK/ROR protein kinase 0.0054 0.0064 0.0205
Loa Loa (eye worm) hypothetical protein 0.0165 0.029 0.0939
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0011 0.0033
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0017 0.05
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.005 0.1464
Entamoeba histolytica hypothetical protein 0.0039 0.0034 0.0568
Mycobacterium tuberculosis Probable lipase LipE 0.019 0.0339 0.1404
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0162 0.0283 0.0803
Toxoplasma gondii kringle domain-containing protein 0.0054 0.0064 0.1578
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0023 0.0655
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0132 0.0131
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.0431 0.043
Schistosoma mansoni lipoxygenase 0.0087 0.013 0.013
Trypanosoma brucei hypothetical protein, conserved 0.019 0.0339 1
Onchocerca volvulus Alhambra homolog 0.0096 0.015 0.0425
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0034 0.0095
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0058 0.0239
Loa Loa (eye worm) hypothetical protein 0.0149 0.0257 0.0832
Loa Loa (eye worm) hypothetical protein 0.0056 0.0067 0.0216
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0108
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0011 0.001
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0029 0.048
Loa Loa (eye worm) hypothetical protein 0.0036 0.0028 0.0089
Trypanosoma brucei DNA polymerase IV, putative 0.007 0.0097 0.2835
Brugia malayi Associated with TFs and helicases family protein 0.0036 0.0028 0.0089
Leishmania major hypothetical protein, conserved 0.0066 0.0088 0.2589
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0018 0.045
Schistosoma mansoni hypothetical protein 0.0032 0.0018 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0124 0.3639
Toxoplasma gondii thioredoxin reductase 0.005 0.0055 0.1362
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0095 0.0095
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0184 0.0328 0.0328
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0047 0.005 0.005
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.026 0.1013
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.005 0.005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0011 0.001
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0034 0.0108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0041 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0124 0.3639
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0032 0.0018 0.045
Schistosoma mansoni survival motor neuron protein 0.0048 0.0051 0.0051
Echinococcus granulosus disco interacting protein 2 0.0027 0.0009 0.0008
Brugia malayi MH2 domain containing protein 0.0245 0.0452 0.1463
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0041 0.0037 0.0037
Brugia malayi Inositol-1 0.0036 0.0027 0.0087
Loa Loa (eye worm) hypothetical protein 0.019 0.0339 0.1098
Echinococcus multilocularis expressed protein 0.0764 0.1507 0.1506
Leishmania major basic transcription factor 3a, putative 0.0037 0.0029 0.0836
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0033
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0009 0.0034
Trichomonas vaginalis maltase-glucoamylase, putative 0.011 0.0178 0.0506
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0069 0.0221
Echinococcus multilocularis chromobox protein 1 0.016 0.028 0.028
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0104 0.0406
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0094 0.0146 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0011 0.003
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0039 0.0034 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0083 0.2422
Echinococcus multilocularis JmjC domain containing protein 4 0.0031 0.0017 0.0017
Schistosoma mansoni bromodomain containing protein 0.0274 0.0512 0.0511
Onchocerca volvulus 0.0258 0.0478 0.1358
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0035 0.0026 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0035 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0028 0.0078
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0028 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0011 0.0033
Loa Loa (eye worm) hypothetical protein 0.019 0.0339 0.1098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0041 0.0114
Echinococcus granulosus chromobox protein 1 0.016 0.028 0.028
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0011 0.0033
Brugia malayi CXXC zinc finger family protein 0.0028 0.0011 0.0033
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.0124 0.3639
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0011 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0011 0.0033
Leishmania major cathepsin L-like protease 0.0067 0.009 0.2651
Mycobacterium tuberculosis Probable hydrolase 0.019 0.0339 0.1404
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.009 0.2651
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0009 0.0032
Plasmodium falciparum cysteine repeat modular protein 1 0.0054 0.0064 0.4237
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0083 0.0124 0.0351
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0046 0.0048 0.0047
Echinococcus granulosus dna polymerase eta 0.0029 0.0014 0.0014
Schistosoma mansoni lamin 0.0056 0.0068 0.0068
Schistosoma mansoni microtubule-associated protein tau 0.4946 1 1
Trypanosoma brucei DNA polymerase eta, putative 0.0029 0.0014 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0034 0.0095
Loa Loa (eye worm) hypothetical protein 0.0054 0.0064 0.0205
Entamoeba histolytica hypothetical protein 0.0184 0.0328 0.5559
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0162 0.0283 0.6998
Trichomonas vaginalis penicillin-binding protein, putative 0.019 0.0339 0.0963
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.002 0.0079
Echinococcus granulosus methyl CpG binding domain protein 2 0.0074 0.0104 0.0103
Mycobacterium tuberculosis Probable conserved lipoprotein 0.019 0.0339 0.1404
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0095 0.1604
Brugia malayi glutathione reductase 0.005 0.0055 0.0177
Trypanosoma cruzi DNA polymerase eta, putative 0.0029 0.0014 0.0398
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0019 0.0051
Loa Loa (eye worm) hypothetical protein 0.0275 0.0514 0.1663
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0034 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0011 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.009 0.2651
Onchocerca volvulus 0.0048 0.0051 0.0145
Mycobacterium ulcerans lipase LipD 0.019 0.0339 0.1324
Loa Loa (eye worm) bromodomain containing protein 0.0076 0.0109 0.0352
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0034 0.0108
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0004 0.0107
Trypanosoma brucei glycosyl hydrolase-like protein 0.011 0.0178 0.525
Mycobacterium tuberculosis Conserved protein 0.019 0.0339 0.1404
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.009 0.2651
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0011 0.001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.0257 0.0832
Leishmania major alpha glucosidase II subunit, putative 0.0162 0.0283 0.8337
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0078 0.0113 0.0364
Echinococcus granulosus transcription factor btf3 0.0037 0.0029 0.0028
Echinococcus granulosus expressed protein 0.0764 0.1507 0.1506
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0011 0.0033
Trypanosoma brucei ISWI complex protein 0.0066 0.0088 0.2589
Schistosoma mansoni jumonji/arid domain-containing protein 0.0126 0.0211 0.0211
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.0339 0.0963
Entamoeba histolytica hypothetical protein 0.0025 0.0004 0.0061
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0011 0.001
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0078 0.0113 0.0112
Loa Loa (eye worm) hypothetical protein 0.0102 0.0161 0.0521
Mycobacterium tuberculosis Conserved hypothetical protein 0.0029 0.0014 0.0056
Loa Loa (eye worm) hypothetical protein 0.0316 0.0597 0.1934
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0011 0.0029
Schistosoma mansoni DNA polymerase eta 0.0029 0.0014 0.0014
Schistosoma mansoni coup transcription factor 0.0028 0.0011 0.001
Schistosoma mansoni lipoxygenase 0.0124 0.0206 0.0205
Plasmodium vivax SET domain protein, putative 0.0222 0.0404 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0029 0.0014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0065 0.0087 0.0279
Entamoeba histolytica hypothetical protein 0.0039 0.0034 0.0568
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0015 0.0048
Loa Loa (eye worm) TAR-binding protein 0.0194 0.0348 0.1125
Brugia malayi hypothetical protein 0.0121 0.0201 0.065
Schistosoma mansoni methyl-cpg binding protein mbd 0.0074 0.0104 0.0103
Brugia malayi SET domain containing protein 0.0045 0.0046 0.0146
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0004 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.019 0.0339 1
Entamoeba histolytica hypothetical protein 0.0036 0.0028 0.0465
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0034 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0026 0.0071
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0078 0.2302
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0259 0.048 0.048
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0011 0.001
Echinococcus multilocularis tar DNA binding protein 0.0194 0.0348 0.0347
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0004 0.0101
Echinococcus granulosus histone lysine methyltransferase setb 0.0295 0.0554 0.0553
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0184 0.0328 0.0328
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0038 0.0122
Entamoeba histolytica hypothetical protein 0.0039 0.0034 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0034 0.0095
Trichomonas vaginalis hypothetical protein 0.0036 0.0028 0.0078
Onchocerca volvulus 0.0035 0.0026 0.0073
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0004 0.0107
Entamoeba histolytica hypothetical protein 0.0036 0.0028 0.0465
Trichomonas vaginalis alpha-glucosidase, putative 0.011 0.0178 0.0506
Loa Loa (eye worm) hypothetical protein 0.0036 0.0028 0.0089
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.0124 0.3639
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0084 0.0327
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0027 0.079
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0094 0.0146 0.0145
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0104 0.3065
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0222 0.0404 1
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0078 0.0113 0.3317
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0034 0.0033
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0275 0.0514 0.1663
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0047 0.0049 0.0048
Schistosoma mansoni chromobox protein 0.0036 0.0028 0.0027
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0084 0.0084
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0029 0.0712
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0031 0.0887
Loa Loa (eye worm) runx1 0.0058 0.0073 0.0234
Brugia malayi NNMT/PNMT/TEMT family protein 0.0275 0.0514 0.1663
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.021 0.6182
Schistosoma mansoni hypothetical protein 0.0047 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0047 0.005 0.005
Brugia malayi hypothetical protein 0.0184 0.0328 0.1062
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0184 0.0761
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0058 0.0239
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0068 0.022
Loa Loa (eye worm) hypothetical protein 0.0131 0.022 0.071
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0034 0.0033
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0038 0.0107
Onchocerca volvulus 0.0087 0.0132 0.0373
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0028 0.0027
Echinococcus granulosus beta LACTamase domain containing family member 0.019 0.0339 0.0339
Echinococcus granulosus sphingosine kinase 1 0.0313 0.059 0.0589
Echinococcus multilocularis chromobox protein 1 0.016 0.028 0.028
Mycobacterium ulcerans hypothetical protein 0.0074 0.0104 0.0406
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0034 0.0033
Giardia lamblia PHD finger protein 15 0.0096 0.015 0.2067
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0078 0.0113 0.0112
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0009 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0011 0.0033
Schistosoma mansoni terminal deoxycytidyl transferase 0.0029 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0031 0.0017 0.0055
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.0083
Echinococcus granulosus JmjC domain containing protein 4 0.0031 0.0017 0.0017
Onchocerca volvulus 0.1754 0.3518 1
Leishmania major hypothetical protein, conserved 0.019 0.0339 1
Plasmodium vivax heterochromatin protein 1, putative 0.0036 0.0028 0.0678
Echinococcus multilocularis lysosomal alpha glucosidase 0.0987 0.196 0.1959
Loa Loa (eye worm) hypothetical protein 0.0039 0.0034 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0316 0.0896
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0027 0.0009 0.0034
Schistosoma mansoni zinc finger protein 0.0066 0.0088 0.0088
Mycobacterium ulcerans beta-lactamase 0.019 0.0339 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0026 0.0071
Onchocerca volvulus 0.0035 0.0026 0.0073
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0055 0.1352
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.019 0.0339 0.1324
Entamoeba histolytica hypothetical protein 0.0184 0.0328 0.5559
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0104 0.1762
Brugia malayi Heterochromatin protein 1 0.016 0.028 0.0906
Loa Loa (eye worm) hypothetical protein 0.019 0.0339 0.1098
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0034 0.0033
Mycobacterium ulcerans hypothetical protein 0.0313 0.059 0.2303
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0316 0.0896
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0026
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0184 0.0761
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.0206 0.0205
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0034 0.0108
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0028 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0011 0.0031
Schistosoma mansoni hypothetical protein 0.0047 0.005 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0028 0.0078
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0009 0.0032
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0104 0.043
Loa Loa (eye worm) hypothetical protein 0.0055 0.0066 0.0213
Schistosoma mansoni cpg binding protein 0.0038 0.0031 0.003
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1542 0.3085 1
Loa Loa (eye worm) hypothetical protein 0.0275 0.0514 0.1663
Echinococcus multilocularis GPCR, family 2 0.0047 0.005 0.005
Leishmania major glycosyl hydrolase-like protein 0.011 0.0178 0.525
Trichomonas vaginalis alpha-glucosidase, putative 0.011 0.0178 0.0506
Loa Loa (eye worm) hypothetical protein 0.0305 0.0574 0.1858
Trichomonas vaginalis esterase, putative 0.019 0.0339 0.0963
Echinococcus granulosus lamin dm0 0.0056 0.0068 0.0068
Plasmodium falciparum heterochromatin protein 1 0.0036 0.0028 0.1833
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0055 0.0055
Echinococcus multilocularis Chromo domain 0.0036 0.0028 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0124 0.3639
Schistosoma mansoni intermediate filament proteins 0.0056 0.0068 0.0068
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0034 0.0033
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0034 0.0033
Brugia malayi jmjC domain containing protein 0.0031 0.0017 0.0055
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.026 0.7651
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0078 0.0113 0.2791
Trichomonas vaginalis glucosylceramidase, putative 0.0271 0.0505 0.1435
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0038 0.0038
Schistosoma mansoni lozenge 0.0058 0.0073 0.0072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0011 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0104 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0006 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.009 0.2651
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0031 0.0017 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0011 0.003
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0055 0.1611
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0034 0.0033
Echinococcus granulosus chromobox protein 1 0.016 0.028 0.028
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0213 0.0387 0.0386
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0035 0.0026 0.0083
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0033
Echinococcus multilocularis geminin 0.0356 0.0678 0.0678
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0162 0.0283 0.0803
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0023 0.0655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.003 0.0085
Brugia malayi PHD-finger family protein 0.0041 0.0038 0.0122
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0036 0.0028 0.1833
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0335 0.0951
Brugia malayi PXA domain containing protein 0.0039 0.0034 0.0108
Loa Loa (eye worm) hypothetical protein 0.019 0.0339 0.1098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0043 0.0041 0.0114
Onchocerca volvulus 0.019 0.0339 0.0963
Trichomonas vaginalis alpha-glucosidase, putative 0.0162 0.0283 0.0803
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0004 0.0015
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0004 0.0107
Brugia malayi Bromodomain containing protein 0.0325 0.0614 0.199
Schistosoma mansoni tar DNA-binding protein 0.0194 0.0348 0.0347
Loa Loa (eye worm) hypothetical protein 0.0047 0.005 0.0161
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.005 0.005
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.005 0.0161
Echinococcus granulosus peregrin 0.0107 0.0171 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0034 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0011 0.0033
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0027 0.079
Schistosoma mansoni hypothetical protein 0.0356 0.0678 0.0678
Trichomonas vaginalis alpha-glucosidase, putative 0.0162 0.0283 0.0803
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0132 0.0131
Brugia malayi beta-NAC-like protein 0.0037 0.0029 0.0092
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0034 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0011 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.058 0.1646
Onchocerca volvulus 0.0054 0.0064 0.018
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0034 0.0033
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.0098 0.2429
Brugia malayi M-phase phosphoprotein, mpp8 0.0131 0.022 0.071
Onchocerca volvulus 0.0772 0.1523 0.4328
Entamoeba histolytica deoxycytidyl transferase, putative 0.0029 0.0014 0.0229
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0029 0.0014 0.0014
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0094 0.0146 0.0145
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0028 0.0465
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0031 0.0017 0.0017
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0009 0.0032
Leishmania major DNA polymerase eta, putative 0.0029 0.0014 0.0398
Loa Loa (eye worm) hypothetical protein 0.0087 0.0132 0.0425
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0011 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0028 0.0078
Brugia malayi Protein kinase domain containing protein 0.0054 0.0064 0.0205
Schistosoma mansoni jumonji domain containing protein 0.0031 0.0017 0.0017
Brugia malayi Valyl-tRNA synthetase 0.0036 0.0028 0.0089
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0078 0.0113 0.3317
Schistosoma mansoni hypothetical protein 0.0066 0.0088 0.0088
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0031 0.0017 0.05
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0011 0.0033
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0026
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.004 0.0035 0.0097
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0036 0.0028 0.1833
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0033
Brugia malayi intermediate filament protein 0.0056 0.0068 0.022
Brugia malayi Latrophilin receptor protein 2 0.0047 0.005 0.0161
Brugia malayi chromobox protein homolog 3 0.0095 0.0148 0.0477
Loa Loa (eye worm) hypothetical protein 0.0313 0.059 0.1911
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0072 0.0101 0.0101
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0054 0.0064 0.1568
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0034 0.0033
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0027 0.0105
Onchocerca volvulus 0.0035 0.0026 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0028 0.0078
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0038 0.0038
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0034 0.0108
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0032 0.0018 0.0523
Echinococcus granulosus lysosomal alpha glucosidase 0.0987 0.196 0.1959
Mycobacterium tuberculosis Conserved protein 0.0313 0.059 0.2442
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0072 0.0101 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0011 0.0033
Schistosoma mansoni inositol monophosphatase 0.0036 0.0027 0.0027
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.0431 0.043
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0034 0.0033
Toxoplasma gondii ABC1 family protein 0.019 0.0339 0.8391
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0161 0.0521
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.005 0.1464
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0011 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0026 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0006 0.0016
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0067 0.0276
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0033
Onchocerca volvulus 0.0074 0.0104 0.0295
Trichomonas vaginalis chromobox protein, putative 0.0036 0.0028 0.0078
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0034 0.0108
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0011 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.003 0.0085
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.0257 0.0832
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.1283 0.256 0.2559
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0033
Loa Loa (eye worm) hypothetical protein 0.0165 0.029 0.0938
Mycobacterium tuberculosis Probable reductase 0.0113 0.0184 0.0761
Loa Loa (eye worm) MH2 domain-containing protein 0.0245 0.0452 0.1463
Plasmodium vivax hypothetical protein, conserved 0.0096 0.015 0.3701
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0028 0.0678
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0011 0.001
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0067 1
Trichomonas vaginalis D-aminoacylase, putative 0.019 0.0339 0.0963
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.005 0.1464
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0027 0.079
Brugia malayi TAR-binding protein 0.0194 0.0348 0.1125
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0011 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.009 0.2651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0006 0.0016
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0095 0.0306
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0078 0.0113 0.3317
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.006 0.0193
Echinococcus granulosus zinc finger protein 0.0086 0.0129 0.0128
Trichomonas vaginalis alpha-glucosidase, putative 0.011 0.0178 0.0506
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0084 0.2081
Loa Loa (eye worm) helicase 0.0036 0.0028 0.0089
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0034 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0316 0.0896
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0078 0.0113 0.032
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0028 0.0465
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.021 0.0868
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.058 0.1646
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0104 0.3065
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0078 0.0113 0.032
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0023 0.0655
Toxoplasma gondii PHD-finger domain-containing protein 0.0096 0.015 0.3709
Brugia malayi Pre-SET motif family protein 0.1542 0.3085 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0194 0.0348 0.1125
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0034 0.0095
Brugia malayi beta-lactamase family protein 0.019 0.0339 0.1098
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0104 0.0406
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0046 0.0048 0.0047
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.0283 0.0916
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0027 0.0009 0.0034
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0259 0.048 0.048
Trypanosoma brucei DNA polymerase IV, putative 0.0083 0.0124 0.3639
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0011 0.0033
Brugia malayi beta-lactamase family protein 0.019 0.0339 0.1098
Plasmodium vivax JmjC domain containing protein 0.0031 0.0017 0.0419
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0258 0.0478 0.0478
Onchocerca volvulus 0.0035 0.0026 0.0073
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0316 0.0896
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0084 0.0084
Plasmodium falciparum JmjC domain-containing protein, putative 0.0031 0.0017 0.1132
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0034 0.0033
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0034 0.0033
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0072 0.0101 0.2973
Brugia malayi AF-10 protein 0.0032 0.0018 0.0057
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0011 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0148 0.0418
Loa Loa (eye worm) RNA binding protein 0.0194 0.0348 0.1125
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0055 0.0055
Trichomonas vaginalis chromobox protein, putative 0.016 0.028 0.0795
Loa Loa (eye worm) hypothetical protein 0.0212 0.0385 0.1246
Schistosoma mansoni hypothetical protein 0.0089 0.0135 0.0134
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0011 0.001
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0067 0.446
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.009 0.2651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0011 0.0031
Schistosoma mansoni protein phosphatase 2C 0.0031 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0041 0.0038 0.0122
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0009 0.0032
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0038 0.0038
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0034 0.0033
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0027 0.0027
Mycobacterium leprae conserved hypothetical protein 0.019 0.0339 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0028 0.0078
Brugia malayi Glycosyl hydrolases family 31 protein 0.0987 0.196 0.6351
Brugia malayi RNA recognition motif domain containing protein 0.0194 0.0348 0.1125
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.0028 0.0689
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0132 0.0425
Schistosoma mansoni chromobox protein 0.0036 0.0028 0.0027
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.019 0.0339 0.0339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0026 0.0071
Loa Loa (eye worm) hypothetical protein 0.0074 0.0104 0.0337
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.005 0.005
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.0757 0.0756
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0067 0.0261
Loa Loa (eye worm) hypothetical protein 0.0027 0.0009 0.0029
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1211 0.2414 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0126 0.0211 0.0211
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.009 0.2651
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0036 0.0028 0.0689
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0095 0.0306
Echinococcus granulosus GPCR family 2 0.0047 0.005 0.005
Brugia malayi Protein cec-1. 0.0036 0.0028 0.0089
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0034 0.0033
Trichomonas vaginalis maltase-glucoamylase, putative 0.0162 0.0283 0.0803
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0041 0.1202
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0094 0.0146 0.0145
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0271 0.0505 0.1636
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0004 0.0014
Echinococcus multilocularis musashi 0.0056 0.0068 0.0068
Trichomonas vaginalis alpha-glucosidase, putative 0.011 0.0178 0.0506
Loa Loa (eye worm) hypothetical protein 0.0176 0.0311 0.1007
Trichomonas vaginalis alpha-glucosidase, putative 0.0162 0.0283 0.0803
Echinococcus multilocularis jumonji domain containing protein 0.0134 0.0227 0.0226
Echinococcus granulosus lysine specific demethylase 5A 0.0126 0.0211 0.0211
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.0028 0.0027
Brugia malayi polk-prov protein 0.0063 0.0083 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0011 0.0033
Brugia malayi Pre-SET motif family protein 0.0222 0.0404 0.1309
Schistosoma mansoni hypothetical protein 0.0048 0.0051 0.0051
Echinococcus granulosus lysine specific demethylase 6a 0.0031 0.0017 0.0017
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0027 0.0076
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.005 0.0161
Plasmodium falciparum phd finger protein, putative 0.0096 0.015 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0027 0.0674
Echinococcus granulosus Chromo domain 0.0036 0.0028 0.0027
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.005 0.0841
Echinococcus granulosus geminin 0.0356 0.0678 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0034 0.0095
Echinococcus multilocularis cpg binding protein 0.0038 0.0031 0.003
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0038 0.1109
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0022 0.0524
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.011 0.0178 0.0506
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0084 0.2469
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0011 0.0033
Onchocerca volvulus 0.0028 0.0011 0.0029
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0096 0.015 0.015
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0155 0.0269 0.0268
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.0124 0.3639
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0055 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0006 0.0015
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0027 0.0009 0.0034
Leishmania major hypothetical protein, conserved 0.0054 0.0064 0.187
Mycobacterium tuberculosis Probable esterase LipL 0.019 0.0339 0.1404
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0308 0.058 0.1646
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0028 0.0078
Loa Loa (eye worm) hypothetical protein 0.0031 0.0017 0.0055
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0046 0.0048 0.0047
Onchocerca volvulus 0.0028 0.0011 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0036 0.0101
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0104 0.3065
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0104 0.0406

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.6 uM Antitumor activity against human NCI-H157 cells by MTT assay ChEMBL. 19534534

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19534534

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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