Detailed information for compound 1063219

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 355.762 | Formula: C16H9ClF3NOS
  • H donors: 1 H acceptors: 2 LogP: 4.39 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(c1ccc(c(c1)F)F)c1scc(n1)c1ccc(c(c1)Cl)F
  • InChi: 1S/C16H9ClF3NOS/c17-10-5-8(1-3-11(10)18)14-7-23-16(21-14)15(22)9-2-4-12(19)13(20)6-9/h1-7,15,22H
  • InChiKey: LHFYQPNPJLIUPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.139 0.2617
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0024 0.0039 0.025
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0156 0.0688 0.0684
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0024 0.0039 0.013
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0173 0.0771 0.0768
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0173 0.0771 0.0768
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0125 0.0534 0.1654
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.039 0.0386
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0031 0.0027
Entamoeba histolytica hypothetical protein 0.0024 0.0039 0.0731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0149 0.0248
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0125 0.0534 0.1781
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0038 0.0034
Mycobacterium ulcerans hypothetical protein 0.0024 0.0038 0.0119
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0125 0.0534 0.3351
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0092 0.0653
Onchocerca volvulus 0.0169 0.075 0.119
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0024 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0188 0.0314
Loa Loa (eye worm) hypothetical protein 0.007 0.0267 0.048
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0015 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0131 0.0218
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0332 0.155 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0033 0.0109
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0034 0.0087 0.4294
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.039 0.0386
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0125 0.0534 0.053
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0163 1
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0401 0.0397
Toxoplasma gondii FATC domain-containing protein 0.007 0.0267 0.3671
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0024 0.0025
Loa Loa (eye worm) hypothetical protein 0.0046 0.0149 0.0256
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0125 0.0534 0.3351
Brugia malayi Bromodomain containing protein 0.0078 0.0305 0.056
Onchocerca volvulus 0.0098 0.0401 0.0607
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0096 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0024 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0306 0.051
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0936 0.3123
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0267 0.0444
Giardia lamblia GTOR 0.0125 0.0534 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0148 0.0253
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0024 0.0039 0.0035
Loa Loa (eye worm) hypothetical protein 0.0043 0.0131 0.0222
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0163 0.1162
Mycobacterium tuberculosis Conserved hypothetical protein 0.0175 0.0779 0.7188
Brugia malayi chromobox protein homolog 3 0.0043 0.0131 0.0229
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0163 0.3058
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.0693 0.1297
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0024 0.0039 0.0035
Schistosoma mansoni importin beta-1 0.0028 0.0059 0.0055
Echinococcus multilocularis 0.0024 0.0039 0.0035
Onchocerca volvulus 0.0034 0.0086 0.0078
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.1794 0.872 0.872
Leishmania major importin beta-1 subunit, putative 0.0023 0.0033 0.0033
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0024 0.0039 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0131 0.0218
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0035 0.0083
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0692 0.2163
Brugia malayi glutaminase DH11.1 0.0266 0.1226 0.231
Schistosoma mansoni chromobox protein 0.0076 0.0296 0.0292
Schistosoma mansoni chromobox protein 0.0076 0.0296 0.0292
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0024 0.0039
Plasmodium vivax hypothetical protein 0.0024 0.0039 0.025
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0024 0.0039 0.0109
Schistosoma mansoni hypothetical protein 0.0019 0.0015 0.001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0075
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0102 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0029 0.0064 0.0214
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0024 0.0039 0.0035
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0024 0.0039 0.0731
Loa Loa (eye worm) phosphatidylinositol 3 0.0125 0.0534 0.0989
Entamoeba histolytica hypothetical protein 0.0024 0.0039 0.0731
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0151 0.0267
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0102 0.1189
Brugia malayi beta-lactamase family protein 0.0037 0.0102 0.0173
Schistosoma mansoni hypothetical protein 0.0299 0.139 0.1387
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0267 0.0444
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0024 0.0039 0.025
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0024 0.0039 0.025
Trichomonas vaginalis esterase, putative 0.0037 0.0102 0.0169
Echinococcus granulosus serine:threonine protein kinase SMG1 0.007 0.0267 0.0263
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0163 0.1162
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0125 0.0534 0.1781
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0052 0.0174 0.017
Loa Loa (eye worm) phosphatidylinositol 3 0.0125 0.0534 0.0989
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Brugia malayi hypothetical protein 0.0109 0.0456 0.0848
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0102 0.0742
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0102 0.0648
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0125 0.0534 0.053
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0024 0.0039 0.0035
Plasmodium vivax ubiquitin activating enzyme, putative 0.0052 0.0174 0.2276
Loa Loa (eye worm) glutaminase 0.0266 0.1226 0.2305
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0216 0.0384
Trichomonas vaginalis glutaminase, putative 0.0266 0.1226 0.204
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0628 0.1168
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.007 0.0267 0.0263
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0035 0.0834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0022
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0024 0.0079
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0151 0.066 0.0656
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0102 0.0169
Brugia malayi Bromodomain containing protein 0.0042 0.0126 0.022
Echinococcus multilocularis geminin 0.0724 0.3473 0.347
Mycobacterium tuberculosis Conserved protein 0.0024 0.0038 0.0137
Toxoplasma gondii hypothetical protein 0.0054 0.0184 0.2423
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0156 0.2009
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.015 0.0836
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0038 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0267 0.0444
Loa Loa (eye worm) beta-lactamase 0.0037 0.0102 0.0166
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0156 0.0688 1
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0035 0.0041
Loa Loa (eye worm) hypothetical protein 0.0049 0.0163 0.0283
Loa Loa (eye worm) phosphatidylinositol 3 0.0024 0.0039 0.0047
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0024 0.0039 0.0035
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0024 0.0443
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0267 0.0444
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0231 0.0226
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0046 0.0147 0.0181
Schistosoma mansoni glutaminase 0.0266 0.1226 0.1222
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0079 0.0306 0.1859
Brugia malayi hypothetical protein 0.0295 0.1366 0.2577
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0039 0.0054
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0038 0.0119
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0024 0.0039 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.039 0.0386
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0326 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0065
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0102 0.0742
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.007 0.0267 0.0263
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0024 0.0039 0.0065
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0163 0.1162
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0024 0.0039 0.025
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0024 0.0039 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Entamoeba histolytica Ran family GTPase 0.0021 0.0022 0.0419
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0034 0.0087 0.0083
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0147 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0156 0.0152
Schistosoma mansoni hypothetical protein 0.0019 0.0015 0.001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0173 0.0771 0.0768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Schistosoma mansoni hypothetical protein 0.0054 0.0188 0.0184
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.0936 0.5985
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0035 0.019
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0125 0.0534 0.1781
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0166
Leishmania major phosphatidylinositol 3-kinase, putative 0.0024 0.0039 0.0054
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0326 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0231 0.0226
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0163 0.0456
Leishmania major phosphatidylinositol 4-kinase, putative 0.0024 0.0039 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0149 0.0248
Toxoplasma gondii target of rapamycin (TOR), putative 0.0125 0.0534 0.7684
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0125 0.0534 0.0995
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0024 0.0039 0.0035
Echinococcus granulosus X box binding protein 1 0.0281 0.1301 0.1298
Brugia malayi hypothetical protein 0.023 0.105 0.1976
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0024 0.0039 0.0109
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0102 0.0173
Loa Loa (eye worm) phosphatidylinositol kinase 0.0024 0.0039 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0092 0.0653
Leishmania major hypothetical protein, conserved 0.0037 0.0102 0.0256
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0024 0.0084
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0326 0.0322
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.007 0.0267 0.089
Giardia lamblia Hypothetical protein 0.0024 0.0039 0.0731
Entamoeba histolytica hypothetical protein 0.0109 0.0456 0.8546
Loa Loa (eye worm) acetyltransferase 0.0157 0.0693 0.1291
Onchocerca volvulus 0.1241 0.6009 1
Schistosoma mansoni ap endonuclease 0.0021 0.0024 0.0019
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0024 0.0039 0.0731
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0024 0.0039 0.0065
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0024 0.0039 0.0731
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0024 0.0039 0.0731
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0039 0.013
Entamoeba histolytica hypothetical protein 0.0109 0.0456 0.8546
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0039 0.0146
Toxoplasma gondii ThiF family protein 0.0034 0.0087 0.0977
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0102 0.0742
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0024 0.0039 0.0731
Loa Loa (eye worm) hypothetical protein 0.023 0.105 0.197
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0024 0.0008
Plasmodium vivax importin-beta 2, putative 0.0028 0.0059 0.0546
Brugia malayi Pre-SET motif family protein 0.0156 0.0688 0.1289
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0166
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0167
Loa Loa (eye worm) hypothetical protein 0.0054 0.0188 0.0331
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0102 0.0339
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0163 0.0456
Mycobacterium tuberculosis Conserved protein 0.0037 0.0102 0.0742
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0024 0.0039 0.013
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0024 0.0039 0.0035
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0102 0.0742
Echinococcus granulosus chromobox protein 1 0.0076 0.0296 0.0292
Loa Loa (eye worm) hypothetical protein 0.0049 0.0163 0.0283
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0024 0.0039 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0102 0.0339
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0102 0.0169
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.039 0.0386
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.0692 0.4383
Entamoeba histolytica hypothetical protein 0.0023 0.0035 0.0656
Brugia malayi Heterochromatin protein 1 0.0076 0.0296 0.0542
Loa Loa (eye worm) hypothetical protein 0.0044 0.0138 0.0235
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.039 0.0721
Schistosoma mansoni microtubule-associated protein tau 0.2054 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0123 0.0206
Entamoeba histolytica hypothetical protein 0.0024 0.0039 0.0731
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0267 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.007 0.0267 0.089
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0024 0.0039 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0156 0.0688 0.0684
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.007 0.0267 0.1601
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0126 0.236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Schistosoma mansoni hypothetical protein 0.0019 0.0015 0.001
Brugia malayi FAT domain containing protein 0.0054 0.0188 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0065
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0024 0.0039 0.0035
Leishmania major hypothetical protein, unknown function 0.0024 0.0039 0.0054
Schistosoma mansoni ran 0.0021 0.0022 0.0018
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0102 0.0742
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.039 0.0386
Schistosoma mansoni hypothetical protein 0.0041 0.0123 0.0119
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0034 0.0087 0.0292
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0216 0.0391
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0038 0.0127
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0024 0.0039 0.1099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Mycobacterium ulcerans hypothetical protein 0.0037 0.0102 0.0648
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0015 0.001
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0024 0.0039 0.0731
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.155 0.5168
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0163 0.133
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0024 0.0039 0.0065
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0015 0.001
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0102 0.0648
Brugia malayi Pre-SET motif family protein 0.109 0.527 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0102 0.0169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0092 0.0653
Trypanosoma cruzi target of rapamycin kinase 3 0.0125 0.0534 0.1781
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0125 0.0534 0.0995
Loa Loa (eye worm) hypothetical protein 0.0083 0.0326 0.0593
Entamoeba histolytica hypothetical protein 0.007 0.0267 0.4996
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0024 0.0039 0.1099
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0034 0.0087 0.0083
Echinococcus granulosus serine protein kinase ATM 0.007 0.0267 0.0263
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0039 0.0054
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.155 0.5168
Onchocerca volvulus 0.0049 0.0163 0.0208
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0022 0.0013
Brugia malayi Importin beta-1 subunit 0.0028 0.0059 0.0091
Loa Loa (eye worm) phosphatidylinositol 3 0.0024 0.0039 0.0047
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0079 0.0306 0.4264
Echinococcus granulosus GPCR family 2 0.0019 0.0015 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0102 1
Echinococcus granulosus tumor protein p63 0.0669 0.3202 0.3199
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0456 0.0452
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0035 1
Echinococcus multilocularis chromobox protein 1 0.0076 0.0296 0.0292
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0102 0.0169
Brugia malayi RNA, U transporter 1 0.008 0.0312 0.0574
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0131 0.0154
Trichomonas vaginalis ran, putative 0.0021 0.0022 0.0037
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0024 0.0039 0.0035
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0163 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.015 0.0501
Toxoplasma gondii ABC1 family protein 0.0037 0.0102 0.1189
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.02 0.0668
Echinococcus multilocularis microtubule associated protein 2 0.2054 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0163 0.1162
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0022 0.0018
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0024 0.0039 0.0035
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0059 0.0055
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0167
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0125 0.0534 0.1654
Leishmania major hypothetical protein, conserved 0.0651 0.3117 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0024 0.0019
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0024 0.0039 0.0731
Brugia malayi ThiF family protein 0.0034 0.0087 0.0146
Loa Loa (eye worm) phosphatidylinositol 3 0.0024 0.0039 0.0047
Mycobacterium ulcerans glutaminase 0.0266 0.1226 1
Mycobacterium leprae Probable lipase LipE 0.0037 0.0102 0.5188
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0035 0.0108
Leishmania major phosphatidylinositol kinase, putative 0.0024 0.0039 0.0054
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0052 0.0174 1
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0102 0.526
Schistosoma mansoni hypothetical protein 0.0047 0.0151 0.0147
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.007 0.0267 0.4996
Echinococcus granulosus snurportin 1 0.0299 0.139 0.1387
Loa Loa (eye worm) hypothetical protein 0.007 0.0266 0.0478
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0024 0.0079
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0125 0.0534 0.1654
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0015 0.001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1597 0.7756 0.7755
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0024 0.0039 0.1099
Loa Loa (eye worm) heterochromatin protein 1 0.0076 0.0296 0.0535
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0024 0.0017
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0125 0.0534 0.3351
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0178
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0692 0.2307
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0024 0.0443
Loa Loa (eye worm) ThiF family protein 0.0034 0.0087 0.0139
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0039 0.0054
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0024 0.0039 0.0065
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0125 0.0534 0.1781
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0047 0.0151 0.0147
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0035 0.0095
Loa Loa (eye worm) hypothetical protein 0.0024 0.0039 0.0047
Echinococcus multilocularis snurportin 1 0.0299 0.139 0.1387
Loa Loa (eye worm) hypothetical protein 0.0098 0.0401 0.0736
Trichomonas vaginalis set domain proteins, putative 0.1241 0.6009 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0024 0.0039 0.0035
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0125 0.0534 0.3351
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0039 0.025
Schistosoma mansoni survival motor neuron protein 0.0047 0.0151 0.0147
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0038 0.0051
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0024 0.0039 0.0035
Schistosoma mansoni bromodomain containing protein 0.0067 0.0248 0.0244
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.039 0.0714
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0024 0.0039 0.0054
Mycobacterium tuberculosis Conserved protein 0.0037 0.0102 0.0742
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0024 0.0039 0.0065
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0024 0.0039 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0166
Schistosoma mansoni ap endonuclease 0.0021 0.0024 0.0019
Onchocerca volvulus 0.0083 0.0326 0.0481
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0163 0.1162
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0054 0.0188 0.0184
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0156 0.2009
Schistosoma mansoni hypothetical protein 0.0024 0.0039 0.0035
Onchocerca volvulus 0.0037 0.0102 0.0105
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0166
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0163 0.029
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0126 0.236
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0024 0.0039 0.0065
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0024 0.0039 0.0035
Brugia malayi MH2 domain containing protein 0.0144 0.0628 0.1175
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0163 0.3058
Brugia malayi PHD-finger family protein 0.0029 0.0061 0.0096
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0015 0.0007
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0024 0.0039 0.0065
Loa Loa (eye worm) hypothetical protein 0.0079 0.0306 0.0555
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.0693 0.0689
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0125 0.0534 1
Onchocerca volvulus 0.0037 0.0102 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0267 0.0444
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0102 0.5188
Leishmania major hypothetical protein, conserved 0.0207 0.0936 0.2954
Toxoplasma gondii hypothetical protein 0.0052 0.0174 0.2276
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.0936 0.3123
Mycobacterium ulcerans hypothetical protein 0.0024 0.0038 0.0119
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0024 0.0039 0.0731
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0024 0.0039 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Schistosoma mansoni hypothetical protein 0.0281 0.1301 0.1298
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0033 0.0054
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0024 0.0039 0.025
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0024 0.0039 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0267 0.0444
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0024 0.0019
Giardia lamblia Phosphatidylinositol 4-kinase 0.0024 0.0039 0.0731
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0034 0.0087 0.0977
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0024 0.0039 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Echinococcus multilocularis chromobox protein 1 0.0076 0.0296 0.0292
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0039 0.0065
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0267 0.0487
Trichomonas vaginalis conserved hypothetical protein 0.003 0.007 0.0116
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0034 0.0087 0.0083
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0163 0.1162
Echinococcus multilocularis GPCR, family 2 0.0019 0.0015 0.001
Mycobacterium ulcerans lipase LipD 0.0037 0.0102 0.0648
Toxoplasma gondii exonuclease III APE 0.0021 0.0024 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0163 0.029
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0125 0.0534 0.3351
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0038 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Loa Loa (eye worm) hypothetical protein 0.0028 0.0059 0.0084
Schistosoma mansoni hypothetical protein 0.0724 0.3473 0.347
Echinococcus multilocularis X box binding protein 1 0.0281 0.1301 0.1298
Schistosoma mansoni zinc finger protein 0.0023 0.0035 0.0031
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0024 0.0039
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0024 0.0039 0.025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0102 0.0097
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0031 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0267 0.0444
Mycobacterium ulcerans beta-lactamase 0.0037 0.0102 0.0648
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0125 0.0534 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0169 0.075 0.0746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Plasmodium falciparum importin beta, putative 0.0028 0.0059 0.2398
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1794 0.872 0.872
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0167
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0024 0.0039 0.013
Echinococcus multilocularis serine protein kinase ATM 0.007 0.0267 0.0263
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0167
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0039 0.0054
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.066 0.0656
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0167
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0024 0.0039 0.013
Echinococcus multilocularis zinc finger protein 0.0023 0.0035 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0306 0.051
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0054 0.0188 0.0184
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0125 0.0534 0.053
Trichomonas vaginalis chromobox protein, putative 0.0046 0.0147 0.0245
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0156 0.026
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0163 0.1162
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0039 0.0109
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0026 0.0021
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.0693 0.0689
Loa Loa (eye worm) hypothetical protein 0.0049 0.0163 0.0283
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0024 0.0039 0.013
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0163 0.029
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0125 0.0534 0.1654
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0163 0.3058
Echinococcus granulosus chromobox protein 1 0.0076 0.0296 0.0292
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.105 0.1046
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0022 0.0018
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0419
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0035 1
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0456 0.0452
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0059 0.0238
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0102 0.0653
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Leishmania major phosphatidylinositol kinase related protein, putative 0.0024 0.0039 0.0054
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.1074 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0156 0.026
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0038 0.0137
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0024 0.0039 0.025
Entamoeba histolytica protein kinase rad3, putative 0.007 0.0267 0.4996
Echinococcus multilocularis tumor protein p63 0.0669 0.3202 0.3199
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0216 0.0391
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0163 0.0456
Brugia malayi beta-lactamase family protein 0.0037 0.0102 0.0173
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0102 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0125 0.0534 0.053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Echinococcus granulosus survival motor neuron protein 1 0.023 0.105 0.1046
Onchocerca volvulus 0.0295 0.1366 0.2223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Loa Loa (eye worm) hypothetical protein 0.006 0.0216 0.0384
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0059 0.0546
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.039 0.0386
Leishmania major mitochondrial DNA polymerase beta 0.0332 0.155 0.4936
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.039 0.0386
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0034 0.0087 0.0426
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0163 0.133
Trypanosoma cruzi hypothetical protein, conserved 0.0627 0.2999 1
Echinococcus granulosus zinc finger protein 0.0023 0.0035 0.0031
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0031 0.0027
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0456 0.0452
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0024 0.0039 0.0731
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0024 0.0039 0.0054
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0102 0.0519
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0296 0.0492
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0125 0.0534 0.053
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0326 0.06
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0035 0.0095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0102 0.0097
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0125 0.0534 0.053
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0123 0.0214
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0038 0.0119
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0102 0.0097
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0102 0.0166
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0059 0.0238
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0126 0.6839
Loa Loa (eye worm) hypothetical protein 0.0052 0.0174 0.0303
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0039 0.0054
Leishmania major phosphatidylinositol 3-kinase, putative 0.0125 0.0534 0.1654
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0628 0.1168
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0156 0.2009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0033 0.0054
Entamoeba histolytica hypothetical protein 0.0109 0.0456 0.8546
Schistosoma mansoni hypothetical protein 0.0724 0.3473 0.347
Plasmodium vivax SET domain protein, putative 0.0156 0.0688 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0024 0.0039 0.0731
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0024 0.0039 0.0065
Echinococcus granulosus importin subunit beta 1 0.0028 0.0059 0.0055
Onchocerca volvulus 0.0037 0.0102 0.0105
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.015 0.0501
Echinococcus granulosus histone lysine methyltransferase setb 0.0173 0.0771 0.0768
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0024 0.0039 0.025
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0024 0.0039 0.0035
Schistosoma mansoni hypothetical protein 0.0109 0.0456 0.0452
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0035 0.019
Loa Loa (eye worm) phosphatidylinositol 3 0.0024 0.0039 0.0047
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0102 0.1197
Leishmania major ubiquitin-activating enzyme-like protein 0.0034 0.0087 0.021
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0102 0.0097
Schistosoma mansoni ran 0.0021 0.0022 0.0018
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0024 0.0039 0.013
Trichomonas vaginalis chromobox protein, putative 0.0076 0.0296 0.0492
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0166
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.109 0.527 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0024 0.0039 0.0035
Loa Loa (eye worm) hypothetical protein 0.0034 0.0086 0.0135
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0267 0.0487
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0052 0.0174 0.017
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0024 0.0039 0.013
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0166
Schistosoma mansoni hypothetical protein 0.002 0.0022 0.0017
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0024 0.0039 0.0109
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0024 0.0039 0.013
Mycobacterium tuberculosis Conserved protein 0.0037 0.0102 0.0742
Brugia malayi ThiF family protein 0.0052 0.0174 0.031
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0039 0.0313
Loa Loa (eye worm) hypothetical protein 0.0295 0.1366 0.2572
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0033 0.0054
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.015 0.0501
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0046 0.0149 0.0497
Schistosoma mansoni hypothetical protein 0.0019 0.0015 0.001
Schistosoma mansoni fkbp-rapamycin associated protein 0.007 0.0267 0.0263
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0038 0.0119
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0038 0.0127
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0035 0.019
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0102 0.0169
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0052 0.0174 0.017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0092 0.0653
Trichomonas vaginalis conserved hypothetical protein 0.003 0.007 0.0116
Echinococcus granulosus geminin 0.0724 0.3473 0.347
Entamoeba histolytica hypothetical protein 0.0024 0.0039 0.0731
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0024 0.0039 0.0065
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0039 0.0054
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0024 0.0039 0.0047
Onchocerca volvulus 0.0047 0.0151 0.0188
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0024 0.0039 0.0065
Entamoeba histolytica hypothetical protein 0.0023 0.0033 0.0612
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0096 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0534 0.0889
Loa Loa (eye worm) phosphatidylinositol 3 0.0024 0.0039 0.0047
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0024 0.0039 0.013
Mycobacterium ulcerans hypothetical protein 0.0049 0.0163 0.1162
Brugia malayi beta-lactamase 0.0037 0.0102 0.0173
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0015 0.001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0102 0.0747
Mycobacterium ulcerans hypothetical protein 0.0175 0.0779 0.6282
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0075
Loa Loa (eye worm) glutaminase 2 0.0266 0.1226 0.2305
Entamoeba histolytica hypothetical protein 0.0109 0.0456 0.8546
Loa Loa (eye worm) hypothetical protein 0.0173 0.0771 0.144
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0024 0.0039 0.0065

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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