Detailed information for compound 1063235

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 513.553 | Formula: C22H22F3N3O4S2
  • H donors: 1 H acceptors: 4 LogP: 3.32 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(c1sc(=O)n(c1C)Cc1ccc(cc1)S(=O)(=O)N(C)C)NCc1ccccc1C(F)(F)F
  • InChi: 1S/C22H22F3N3O4S2/c1-14-19(20(29)26-12-16-6-4-5-7-18(16)22(23,24)25)33-21(30)28(14)13-15-8-10-17(11-9-15)34(31,32)27(2)3/h4-11H,12-13H2,1-3H3,(H,26,29)
  • InChiKey: JAQIAAGRSNRXMG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0074 0.0112 0.6818
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0473 0.0835 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.043 0.0757 0.805
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0112 0.1186
Loa Loa (eye worm) phosphatidylinositol 3 0.0126 0.0207 0.179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0479 0.0845 0.8993
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0281 0.0486 0.5625
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0157 0.0263 1
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0189 0.032 0.3407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0457 0.0804 0.8557
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0058 0.0083 0.0238
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0009 0.0059
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0265 0.0457 0.0457
Echinococcus multilocularis geminin 0.0881 0.1573 0.1573
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0281 0.0486 0.1401
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0171 0.0288 0.1806
Trichomonas vaginalis PIKK family atypical protein kinase 0.0479 0.0845 0.8993
Trichomonas vaginalis PIKK family atypical protein kinase 0.0265 0.0457 0.4859
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0512 0.0904 0.9619
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0022 0.0142
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0101 0.0161 0.1717
Trypanosoma brucei cytochrome P450, putative 0.0087 0.0136 0.1559
Loa Loa (eye worm) hypothetical protein 0.0293 0.0509 0.4403
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0007 0.0047
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0007 0.0047
Schistosoma mansoni hypothetical protein 0.005 0.0068 0.0432
Loa Loa (eye worm) hypothetical protein 0.0074 0.0112 0.0973
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0009 0.0009
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0023 0.0232
Trypanosoma cruzi hypothetical protein, conserved 0.1928 0.3466 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.007 0.0607
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0021 0.0211
Loa Loa (eye worm) cytochrome P450 family protein 0.0087 0.0136 0.1173
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0021 0.0221
Brugia malayi hypothetical protein 0.0016 0.0007 0.0078
Brugia malayi Bromodomain containing protein 0.0039 0.0048 0.0511
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.0841 0.8944
Loa Loa (eye worm) G protein alpha subunit 3 0.0016 0.0007 0.0064
Toxoplasma gondii FATC domain-containing protein 0.0281 0.0486 0.5749
Loa Loa (eye worm) phosphatidylinositol 3 0.0101 0.0161 0.1397
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0016 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0881 0.1573 1
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0112 0.0385
Schistosoma mansoni hypothetical protein 0.0101 0.0161 0.1026
Loa Loa (eye worm) hypothetical protein 0.0192 0.0326 0.2818
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0101 0.0161 0.0463
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0157 0.0263 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0489 0.0864 0.9187
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0112 0.0112
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.0827 0.88
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0007 0.0007
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0112 0.0385
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.009 0.009
Brugia malayi Importin beta-1 subunit 0.003 0.0033 0.0353
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0227 0.039 0.4507
Loa Loa (eye worm) hypothetical protein 0.0107 0.0172 0.149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0064
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0227 0.039 0.4141
Loa Loa (eye worm) CYP4Cod1 0.0087 0.0136 0.1173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0285 0.0494 0.5247
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0161 0.603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.0841 0.8944
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.0841 0.8944
Mycobacterium ulcerans beta-lactamase 0.0074 0.0112 0.0646
Loa Loa (eye worm) phosphatidylinositol 3 0.0468 0.0826 0.7149
Schistosoma mansoni hypothetical protein 0.0015 0.0006 0.0039
Schistosoma mansoni hypothetical protein 0.0192 0.0326 0.207
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0512 0.0904 0.2606
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0101 0.0161 0.5892
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0489 0.0864 0.5492
Onchocerca volvulus 0.0051 0.007 0.4073
Toxoplasma gondii target of rapamycin (TOR), putative 0.0477 0.0841 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0281 0.0486 0.5168
Trypanosoma cruzi ISWI complex protein 0.0015 0.0006 0.0015
Onchocerca volvulus 0.0028 0.003 0.1444
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0007 0.0007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0068 0.0068
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.001 0.001
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0532 0.094 0.271
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0281 0.0486 0.3092
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0293 0.0509 0.6017
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0053 0.0461
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0112 0.0714
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0007 0.0067
Trichomonas vaginalis esterase, putative 0.0074 0.0112 0.1186
Schistosoma mansoni hypothetical protein 0.0021 0.0016 0.0101
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0101 0.0161 0.603
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0112 0.0714
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.5539 1 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0101 0.0161 0.0161
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0227 0.039 0.1122
Trypanosoma cruzi cytochrome P450, putative 0.0087 0.0136 0.0388
Schistosoma mansoni hypothetical protein 0.005 0.0068 0.0432
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0512 0.0904 0.2606
Brugia malayi cytochrome P450 0.0058 0.0083 0.0888
Mycobacterium ulcerans hypothetical protein 0.0074 0.0112 0.0646
Mycobacterium tuberculosis Conserved hypothetical protein 0.0101 0.0161 0.1037
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0126 0.0207 0.0594
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0007 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0112 0.0321
Loa Loa (eye worm) beta-lactamase 0.0074 0.0112 0.0973
Trichomonas vaginalis PIKK family atypical protein kinase 0.0111 0.018 0.1901
Schistosoma mansoni fkbp-rapamycin associated protein 0.0265 0.0457 0.2908
Loa Loa (eye worm) glutaminase 0.0306 0.0532 0.4602
Leishmania major hypothetical protein, unknown function 0.0101 0.0161 0.044
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0424 0.0745 0.7928
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0157 0.0263 0.279
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0374 0.0654 0.6962
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0512 0.0904 0.0904
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0157 0.0263 0.0756
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0374 0.0654 0.0654
Loa Loa (eye worm) hypothetical protein 0.003 0.0033 0.0287
Loa Loa (eye worm) phosphatidylinositol 3 0.0489 0.0864 0.7477
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0101 0.0161 0.0161
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0489 0.0864 0.9188
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0068 0.0589
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0101 0.0161 0.0161
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0064
Loa Loa (eye worm) hypothetical protein 0.0118 0.0192 0.1665
Echinococcus multilocularis expressed protein 0.0016 0.0007 0.0007
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0007 0.0047
Leishmania major cytochrome p450-like protein 0.0058 0.0083 0.0226
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0016 0.0007 0.0067
Echinococcus multilocularis 0.0101 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.005 0.0068 0.0589
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0721 0.1282 0.1282
Echinococcus granulosus GPCR family 2 0.005 0.0068 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0467 0.0823 0.875
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0112 0.1186
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0112 0.0321
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0157 0.0263 0.2277
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0007 0.0067
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0374 0.0654 0.0654
Schistosoma mansoni glutaminase 0.0306 0.0532 0.338
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0157 0.0263 0.279
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0157 0.0263 0.3072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0467 0.0823 0.875
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0033 0.0373
Brugia malayi PHD-finger family protein 0.0027 0.0027 0.0283
Loa Loa (eye worm) hypothetical protein 0.0101 0.0161 0.1397
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0721 0.1282 0.1282
Loa Loa (eye worm) hypothetical protein 0.0041 0.0052 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0467 0.0823 0.8751
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0093 0.0984
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0016 0.0007 0.0078
Leishmania major phosphatidylinositol kinase related protein, putative 0.0117 0.019 0.0519
Leishmania major cytochrome p450-like protein 0.0087 0.0136 0.0369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0316 0.055 0.5842
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0016 0.0007 0.0007
Brugia malayi Cytochrome P450 family protein 0.0087 0.0136 0.1441
Brugia malayi glutaminase DH11.1 0.0306 0.0532 0.5655
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0101 0.0161 0.1717
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0101 0.0161 0.1708
Loa Loa (eye worm) hypothetical protein 0.0197 0.0334 0.2891
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0227 0.039 0.2479
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0058 0.0083 0.0226
Mycobacterium tuberculosis Conserved protein 0.0074 0.0112 0.0385
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0016 0.0007 0.0064
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0157 0.0263 1
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0007 0.0047
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0044 0.0044
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0007 0.0078
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0489 0.0864 0.9187
Brugia malayi Cytochrome P450 family protein 0.0183 0.031 0.33
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0489 0.0864 0.0864
Brugia malayi Bromodomain containing protein 0.0077 0.0118 0.1253
Schistosoma mansoni hypothetical protein 0.0107 0.0172 0.1094
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0157 0.0263 0.3072
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0489 0.0864 0.0864
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0007 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0112 0.1186
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0101 0.0161 0.5892
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0112 0.0646
Echinococcus multilocularis 0.0058 0.0083 0.0083
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0016 0.0007 0.0047
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0016 0.0007 0.0067
Brugia malayi G-protein alpha subunit 0.0016 0.0007 0.0078
Onchocerca volvulus 0.0101 0.0161 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0164 0.0274 0.2909
Loa Loa (eye worm) cytochrome P450 family protein 0.0183 0.031 0.2685
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0112 0.0385
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0007 0.0067
Loa Loa (eye worm) cytochrome P450 family protein 0.0087 0.0136 0.1173
Echinococcus multilocularis importin subunit beta 1 0.003 0.0033 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.006 0.0382
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0101 0.0161 0.1026
Trichomonas vaginalis conserved hypothetical protein 0.0293 0.0509 0.5405
Echinococcus granulosus expressed protein 0.0016 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0028 0.003 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0467 0.0823 0.875
Echinococcus granulosus bloom syndrome protein 0.0023 0.0021 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0374 0.0654 0.4161
Loa Loa (eye worm) hypothetical protein 0.0045 0.0059 0.051
Brugia malayi Cytochrome P450 family protein 0.0058 0.0083 0.0888
Leishmania major phosphatidylinositol 3-kinase, putative 0.0157 0.0263 0.0718
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0009 0.0009
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0479 0.0846 0.979
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0112 0.1195
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0016 0.0007 0.0047
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0157 0.0263 0.1672
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0101 0.0161 0.1859
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0512 0.0904 0.0904
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0112 0.3711
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0157 0.0263 0.2798
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0479 0.0846 0.2315
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0093 0.0093
Echinococcus granulosus dnaJ subfamily B 0.0404 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0071 0.0107 0.0927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.0841 0.8944
Trichomonas vaginalis PIKK family atypical protein kinase 0.0489 0.0864 0.9187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0374 0.0654 0.0654
Echinococcus granulosus snurportin 1 0.0324 0.0564 0.0564
Schistosoma mansoni cytochrome P450 0.0058 0.0083 0.0531
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0093 0.0801
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0265 0.0457 0.0457
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.001 0.0067
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0457 0.0804 0.9314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0285 0.0494 0.5247
Leishmania major phosphatidylinositol 4-kinase, putative 0.0101 0.0161 0.044
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0016 0.0007 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0285 0.0494 0.5247
Echinococcus multilocularis cpg binding protein 0.0032 0.0036 0.0036
Loa Loa (eye worm) phosphatidylinositol 3 0.0101 0.0161 0.1397
Echinococcus granulosus cytochrome P450 2K1 0.0058 0.0083 0.0083
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.007 0.0446
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0227 0.039 0.4141
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0512 0.0904 0.5749
Loa Loa (eye worm) hypothetical protein 0.0039 0.0048 0.0417
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0374 0.0654 0.4161
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0101 0.0161 0.0161
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0023 0.0232
Entamoeba histolytica hypothetical protein 0.0461 0.0813 0.8649
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0112 0.0385
Giardia lamblia GTOR 0.0489 0.0864 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0335 0.0584 0.0584
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0489 0.0864 0.249
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0016 0.0007 0.0007
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0016 0.0137
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0192 0.0326 0.0326
Mycobacterium ulcerans glutaminase 0.0306 0.0532 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0157 0.0263 0.0263
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0093 0.0588
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0016 0.0007 0.0047
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0265 0.0457 0.4865
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0023 0.0232
Echinococcus granulosus geminin 0.0881 0.1573 0.1573
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.0841 0.8944
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0265 0.0458 0.4862
Entamoeba histolytica hypothetical protein 0.0025 0.0023 0.0232
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0532 0.094 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.0262 0.2266
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0101 0.0161 0.0463
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0068 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0192 0.0326 0.3456
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0227 0.039 0.4141
Schistosoma mansoni hypothetical protein 0.005 0.0068 0.0432
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.006 0.0382
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0012 0.0075
Brugia malayi beta-lactamase 0.0074 0.0112 0.1195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0276 0.0479 0.5086
Schistosoma mansoni importin beta-1 0.003 0.0033 0.0211
Echinococcus multilocularis zinc finger protein 0.0021 0.0017 0.0017
Brugia malayi RNA binding protein 0.0063 0.0093 0.0984
Echinococcus granulosus importin subunit beta 1 0.003 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0074 0.0112 0.0973
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0016 0.0007 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0461 0.0813 0.8649
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0112 0.0112
Schistosoma mansoni zinc finger protein 0.0015 0.0006 0.0039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0101 0.0161 0.1717
Echinococcus multilocularis snurportin 1 0.0324 0.0564 0.0564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0467 0.0823 0.8751
Echinococcus granulosus tumor protein p63 0.0347 0.0605 0.0605
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0101 0.0161 0.0463
Loa Loa (eye worm) hypothetical protein 0.0074 0.0112 0.0973
Trichomonas vaginalis PIKK family atypical protein kinase 0.0297 0.0516 0.549
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0112 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0467 0.0823 0.8751
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0048 0.0503
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0489 0.0864 0.2365
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0021 0.0211
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0007 0.0078
Mycobacterium leprae conserved hypothetical protein 0.0101 0.0161 1
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0112 0.0646
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0074 0.0112 0.0973
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.0262 0.2785
Echinococcus granulosus cpg binding protein 0.0032 0.0036 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0374 0.0654 0.4161
Leishmania major hypothetical protein, conserved 0.0074 0.0112 0.0305
Plasmodium vivax importin-beta 2, putative 0.003 0.0033 0.1021
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0053 0.0566
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0016 0.0007 0.0064
Schistosoma mansoni hypothetical protein 0.0881 0.1573 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0101 0.0161 0.1854
Leishmania major phosphatidylinositol 3-kinase, putative 0.0457 0.0804 0.2202
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.0262 0.2785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.0841 0.8944
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0093 0.0588
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0424 0.0745 0.7928
Loa Loa (eye worm) phosphatidylinositol 3 0.0101 0.0161 0.1397
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0022 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.0841 0.8944
Trichomonas vaginalis PIKK family atypical protein kinase 0.0469 0.0827 0.88
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0161 0.1708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0457 0.0804 0.8557
Loa Loa (eye worm) phosphatidylinositol kinase 0.0101 0.0161 0.1397
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0101 0.0161 0.603
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0064
Onchocerca volvulus 0.0074 0.0112 0.6818
Echinococcus granulosus serine protein kinase ATM 0.0281 0.0486 0.0486
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0101 0.0161 0.1859
Loa Loa (eye worm) hypothetical protein 0.018 0.0303 0.2625
Mycobacterium tuberculosis Conserved protein 0.0074 0.0112 0.0385
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0068 0.0068
Schistosoma mansoni cpg binding protein 0.0032 0.0036 0.0229
Loa Loa (eye worm) RNA binding protein 0.0063 0.0093 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0467 0.0823 0.8751
Leishmania major hypothetical protein, conserved 0.0015 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0036 0.0043 0.0375
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0489 0.0864 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0374 0.0654 0.0654
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0192 0.0326 0.0326
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0354 0.0619 0.651
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0033 0.0317
Leishmania major cytochrome p450-like protein 0.0058 0.0083 0.0226
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0112 0.1291
Trichomonas vaginalis glutaminase, putative 0.0306 0.0532 0.565
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0053 0.0053
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0281 0.0486 0.5173
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0157 0.0263 0.1672
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0489 0.0864 0.9187
Entamoeba histolytica hypothetical protein 0.0101 0.0161 0.1708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0479 0.0845 0.8993
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0101 0.0161 0.1708
Loa Loa (eye worm) hypothetical protein 0.0335 0.0584 0.5059
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0303 0.0527 0.6095
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0101 0.0161 0.1854
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.0709 0.0709
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.0564 0.4883
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0489 0.0864 1
Loa Loa (eye worm) cytochrome P450 0.0058 0.0083 0.0722
Mycobacterium leprae Probable lipase LipE 0.0074 0.0112 0.3711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0489 0.0864 0.9187
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0101 0.0161 0.0161
Plasmodium vivax hypothetical protein 0.0101 0.0161 0.603
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0532 0.094 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0157 0.0263 0.0718
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0016 0.0007 0.0047
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0016 0.0007 0.0078
Echinococcus multilocularis serine protein kinase ATM 0.0281 0.0486 0.0486
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.001 0.0067
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0101 0.0161 0.1026
Loa Loa (eye worm) glutaminase 2 0.0306 0.0532 0.4602
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0112 0.0385
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0007 0.0007
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0172 0.1831
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0101 0.0161 0.1854
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0101 0.0161 0.1708
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0532 0.094 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.0262 0.2266
Brugia malayi Cytochrome P450 family protein 0.0087 0.0136 0.1441
Brugia malayi RNA, U transporter 1 0.0086 0.0134 0.1429
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0058 0.0083 0.0238
Echinococcus granulosus zinc finger protein 0.0021 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0404 0.0709 0.4506
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0009 0.0059
Brugia malayi CXXC zinc finger family protein 0.0028 0.003 0.0315
Schistosoma mansoni zinc finger protein 0.0021 0.0017 0.0107
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0489 0.0864 0.249
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0101 0.0161 0.0463
Schistosoma mansoni hypothetical protein 0.005 0.0068 0.0432
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0087 0.0136 0.1162
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0157 0.0263 0.0756
Entamoeba histolytica hypothetical protein 0.0281 0.0486 0.5168
Brugia malayi FAT domain containing protein 0.0192 0.0326 0.3463
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0016 0.0007 0.0007
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0016 0.0007 0.0067
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0058 0.0083 0.0956
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.0498 0.5296
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0016 0.0007 0.0047
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0532 0.094 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0112 0.0973
Entamoeba histolytica hypothetical protein 0.0101 0.0161 0.1708
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.008 0.0876
Echinococcus multilocularis GPCR, family 2 0.005 0.0068 0.0068
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0721 0.1282 0.8151
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0093 0.0801
Toxoplasma gondii ABC1 family protein 0.0074 0.0112 0.1267
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0016 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0032 0.0036 0.0229
Brugia malayi TAR-binding protein 0.0063 0.0093 0.0984
Entamoeba histolytica hypothetical protein 0.0101 0.0161 0.1708
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0101 0.0161 0.1026
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0532 0.094 1
Leishmania major importin beta-1 subunit, putative 0.0025 0.0023 0.006
Trypanosoma cruzi ISWI complex protein 0.0015 0.0006 0.0015
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0016 0.0007 0.0064
Echinococcus multilocularis Zinc finger, PHD finger 0.0157 0.0263 0.0263
Schistosoma mansoni hypothetical protein 0.0058 0.0083 0.0531
Echinococcus multilocularis tumor protein p63 0.0347 0.0605 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.0457 0.0804 0.8557
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0068 0.0723
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0064
Loa Loa (eye worm) hypothetical protein 0.0018 0.001 0.0091
Schistosoma mansoni bromodomain containing protein 0.0065 0.0096 0.0613
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0157 0.0263 0.279
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0532 0.094 0.271
Loa Loa (eye worm) hypothetical protein 0.0265 0.0457 0.3959
Mycobacterium tuberculosis Conserved protein 0.0074 0.0112 0.0385
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0016 0.0007 0.0078
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0374 0.0654 0.5666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0479 0.0845 0.8993
Entamoeba histolytica protein kinase rad3, putative 0.0265 0.0457 0.4859
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.018 0.0303 0.0872
Trypanosoma brucei ISWI complex protein 0.0015 0.0006 0.006
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0489 0.0864 0.2365
Trypanosoma cruzi target of rapamycin kinase 3 0.0479 0.0846 0.2437
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0053 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0093 0.0588
Brugia malayi beta-lactamase family protein 0.0074 0.0112 0.1195
Toxoplasma gondii cytochrome p450 superfamily protein 0.0058 0.0083 0.092
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0048 0.0503
Brugia malayi beta-lactamase family protein 0.0074 0.0112 0.1195
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0016 0.0007 0.0078
Loa Loa (eye worm) phosphatidylinositol 3 0.0101 0.0161 0.1397
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0016 0.0007 0.0078
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0157 0.0263 0.279
Echinococcus granulosus tar DNA binding protein 0.0063 0.0093 0.0093
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0021 0.0021
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.001 0.0091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0087 0.0554
Loa Loa (eye worm) RecQ helicase 0.0023 0.0021 0.018
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0335 0.0584 0.0584
Mycobacterium ulcerans lipase LipD 0.0074 0.0112 0.0646
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.0161 0.1708
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0468 0.0826 0.2261
Loa Loa (eye worm) phosphatidylinositol 3 0.065 0.1155 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0265 0.0457 0.1317
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0276 0.0479 0.5086
Plasmodium falciparum importin beta, putative 0.003 0.0033 0.0708
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0016 0.0007 0.0067
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0112 0.1186
Leishmania major hypothetical protein, conserved 0.2029 0.3649 1
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0016 0.0007 0.0064
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0227 0.039 0.4141
Onchocerca volvulus 0.0074 0.0112 0.6818
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0157 0.0263 0.279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0479 0.0845 0.8993
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0468 0.0826 0.956
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0227 0.039 0.4141
Trypanosoma cruzi cytochrome P450, putative 0.0087 0.0136 0.0388
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0064
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.144 0.144
Loa Loa (eye worm) hypothetical protein 0.0074 0.0112 0.0973
Trichomonas vaginalis conserved hypothetical protein 0.0164 0.0274 0.2909
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0023 0.0063
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0335 0.0584 0.6217
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0112 0.0973
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0058 0.0083 0.0238
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0068 0.0068
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0157 0.0263 0.0263
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0112 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0468 0.0826 0.8783
Entamoeba histolytica G protein alpha subunit, putative 0.0016 0.0007 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0457 0.0804 0.8557
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0121 0.0198 0.2281
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0157 0.0263 0.3037
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.003 0.0256
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0227 0.039 0.4147
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0112 0.1186
Onchocerca volvulus 0.0101 0.0161 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0093 0.0588
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0016 0.0007 0.0078
Schistosoma mansoni GTP-binding protein alpha subunit 0.0016 0.0007 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0093 0.0588
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0016 0.0007 0.0047
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0033 0.0373
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0112 0.4115
Loa Loa (eye worm) hypothetical protein 0.0029 0.003 0.0263
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.001 0.001
Leishmania major phosphatidylinositol kinase, putative 0.0101 0.0161 0.044
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0117 0.019 0.0547
Brugia malayi Latrophilin receptor protein 2 0.005 0.0068 0.0723
Schistosoma mansoni hypothetical protein 0.0324 0.0564 0.3587
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0016 0.0007 0.0078
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0101 0.0161 0.603

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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