Detailed information for compound 106536

Basic information

Technical information
  • TDR Targets ID: 106536
  • Name: 3-[(3-fluorophenyl)methyl]-1H-imidazole-2-thi one
  • MW: 208.255 | Formula: C10H9FN2S
  • H donors: 1 H acceptors: 0 LogP: 1.52 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)Cn1cc[nH]c1=S
  • InChi: 1S/C10H9FN2S/c11-9-3-1-2-8(6-9)7-13-5-4-12-10(13)14/h1-6H,7H2,(H,12,14)
  • InChiKey: BVQNVINXXGBFBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(3-fluorobenzyl)-4-imidazoline-2-thione
  • 1-[(3-fluorophenyl)methyl]-3H-imidazole-2-thione
  • 1-(3-fluorobenzyl)-3H-imidazole-2-thione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine beta-hydroxylase Starlite/ChEMBL References
Bos taurus Dopamine beta-hydroxylase Starlite/ChEMBL References
Homo sapiens dopamine beta-hydroxylase (dopamine beta-monooxygenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni dopamine-beta-monooxygenase Get druggable targets OG5_129281 All targets in OG5_129281
Schistosoma japonicum ko:K00503 dopamine beta-monooxygenase [EC1.14.17.1], putative Get druggable targets OG5_129281 All targets in OG5_129281
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0025 0.0059
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0172 0.2242
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0098
Brugia malayi DOMON domain containing protein 0.0086 0.0478 0.1738
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0089 0.0501 0.6774
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0109 0.0353
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0473
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0033 0.0153 0.1644
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0109 0.0369
Echinococcus granulosus geminin 0.0343 0.2063 0.2767
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0023 0.0089 0.0162
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0009 0.0005
Brugia malayi nuclear receptor RXR 0.0012 0.0025 0.0059
Leishmania major DNA polymerase eta, putative 0.002 0.0072 0.0715
Trichomonas vaginalis D-aminoacylase, putative 0.0128 0.0736 0.2593
Entamoeba histolytica phosphoglycerate kinase, putative 0.0089 0.0501 0.5546
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0106 0.1105
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0075 0.0413 0.5552
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0109 0.0103
Brugia malayi nuclear hormone receptor family member odr-7 0.0012 0.0025 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0124 0.1316
Schistosoma mansoni hypothetical protein 0.0029 0.0129 0.0166
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.0025 0.0026
Brugia malayi Pre-SET motif family protein 0.006 0.0318 0.1145
Brugia malayi glutathione reductase 0.0104 0.059 0.2153
Mycobacterium tuberculosis Probable lipase LipE 0.0128 0.0736 0.1465
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0109 0.0139
Schistosoma mansoni hypothetical protein 0.0086 0.048 0.0638
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0109 0.0139
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0033 0.0156 0.0202
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0113 0.0385
Echinococcus multilocularis geminin 0.0343 0.2063 0.2059
Echinococcus multilocularis phosphoglycerate kinase 1 0.0089 0.0501 0.0496
Echinococcus granulosus mixed lineage leukemia protein mll 0.0011 0.0018 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0128 0.0736 0.2692
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0069 0.0373 0.0368
Plasmodium vivax SET domain protein, putative 0.006 0.0318 0.4255
Brugia malayi hypothetical protein 0.0012 0.0025 0.0059
Loa Loa (eye worm) MH2 domain-containing protein 0.0063 0.0337 0.1219
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0172 0.1868
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.0022 0.0053
Loa Loa (eye worm) hypothetical protein 0.0089 0.0501 0.1828
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0075 0.0758
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0021 0.0081 0.0826
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0109 0.0369
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0025 0.0106 0.0372
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0066 0.0354 0.0469
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0109 0.0103
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0014 0.0036 0.0041
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0109 0.0375
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0009 0.0033
Trichomonas vaginalis glutamate synthase, putative 0.001 0.0009 0.0033
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0022 0.0022
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0056 0.0294 0.0575
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0025 0.0059
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0109 0.0139
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0072 0.0715
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.0128 0.0736 0.2696
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0172 0.2803
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0022 0.0022
Mycobacterium tuberculosis Probable dehydrogenase 0.0237 0.141 0.2825
Toxoplasma gondii hypothetical protein 0.0024 0.0101 0.1257
Schistosoma mansoni cpg binding protein 0.0039 0.0188 0.0245
Trypanosoma brucei polo-like protein kinase 0.0113 0.0645 0.7286
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0109 0.0369
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0172 0.1868
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0021 0.008 0.0808
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0031 0.0035
Mycobacterium ulcerans beta-lactamase 0.0128 0.0736 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.004 0.0196 0.019
Schistosoma mansoni survival motor neuron protein 0.0036 0.0169 0.022
Brugia malayi orphan nuclear receptor NR2E1 0.0012 0.0025 0.0059
Mycobacterium ulcerans hypothetical protein 0.008 0.0441 0.594
Brugia malayi nuclear hormone receptor family member nhr-6 0.0012 0.0025 0.0059
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0645 0.2273
Brugia malayi RNA binding protein 0.0058 0.0309 0.1111
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0021 0.008 0.0074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0128 0.0736 0.0981
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0009 0.0033
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0072 0.0391 0.4377
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0034 0.0038
Brugia malayi RNA recognition motif domain containing protein 0.0058 0.0309 0.1111
Brugia malayi nuclear hormone receptor 0.0012 0.0025 0.0059
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0022 0.0022
Giardia lamblia Kinase, PLK 0.0113 0.0645 0.7162
Echinococcus multilocularis inositol monophosphatase 1 0.0025 0.0106 0.01
Loa Loa (eye worm) transcription factor SMAD2 0.0063 0.0337 0.1219
Entamoeba histolytica serine/threonine protein kinase, putative 0.0113 0.0645 0.7162
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0075 0.007
Trypanosoma cruzi polo-like protein kinase, putative 0.0113 0.0645 0.7286
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0124 0.1316
Loa Loa (eye worm) hypothetical protein 0.0086 0.048 0.1751
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0098
Giardia lamblia Phosphoglycerate kinase 0.0089 0.0501 0.5546
Trypanosoma cruzi PAB1-binding protein , putative 0.0066 0.0355 0.3962
Schistosoma mansoni hypothetical protein 0.0215 0.1274 0.1706
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0075 0.0758
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0098
Loa Loa (eye worm) hypothetical protein 0.0069 0.0373 0.1355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0124 0.1316
Onchocerca volvulus 0.0012 0.0022 0.0044
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0025 0.0026
Schistosoma mansoni hypothetical protein 0.0029 0.0132 0.017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0109 0.0369
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.0022 0.0053
Mycobacterium ulcerans lipase LipD 0.0128 0.0736 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0071 0.0388 0.0514
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0109 0.0369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0124 0.1316
Brugia malayi nuclear hormone receptor 0.0026 0.0109 0.0369
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0172 0.1868
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0006
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0109 0.0103
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0022 0.0022
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0025 0.0106 0.0372
Brugia malayi Thioredoxin reductase 0.0104 0.059 0.2153
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.001 0.0009 0.0033
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0021 0.008 0.0261
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0022 0.0022
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0151 0.0881 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0109 0.0375
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0036 0.0169 0.0593
Loa Loa (eye worm) hypothetical protein 0.0448 0.2707 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.022 0.0785
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0264 0.1573 0.3154
Brugia malayi hypothetical protein 0.0174 0.1024 0.3761
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0294 0.0388
Schistosoma mansoni hypothetical protein 0.0036 0.0169 0.022
Plasmodium vivax ataxin-2 like protein, putative 0.0066 0.0355 0.4756
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.0386 0.5184
Echinococcus multilocularis microtubule associated protein 2 0.1217 0.7443 0.7441
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0264 0.1573 1
Onchocerca volvulus 0.0012 0.0022 0.0044
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0018 0.0017
Onchocerca volvulus 0.0044 0.022 0.0744
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0154 0.0896 0.316
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0075 0.091
Loa Loa (eye worm) hypothetical protein 0.0026 0.0109 0.0375
Trichomonas vaginalis penicillin-binding protein, putative 0.0128 0.0736 0.2593
Echinococcus granulosus dna polymerase kappa 0.002 0.0075 0.0094
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0109 0.0139
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0075 0.0758
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0109 0.0369
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0346
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0009 0.0033
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0172 0.1868
Trypanosoma cruzi PAB1-binding protein , putative 0.0066 0.0355 0.3962
Schistosoma mansoni bromodomain containing protein 0.0035 0.0168 0.0218
Mycobacterium tuberculosis Probable esterase LipL 0.0128 0.0736 0.1465
Mycobacterium leprae conserved hypothetical protein 0.0012 0.0026 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0124 0.1316
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0053
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0645 0.2273
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0021 0.0081 0.0826
Brugia malayi steroid hormone receptor 0.0026 0.0109 0.0369
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0154 0.0896 0.316
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0022 0.0022
Trypanosoma brucei phosphoglycerate kinase 0.0089 0.0501 0.5642
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0025 0.0106 0.1086
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0065
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0019 0.0067 0.0061
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.0022 0.0053
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0026 0.0193
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0065
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0128 0.0736 0.2696
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0154 0.0896 0.316
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.0022 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0154 0.0896 0.316
Loa Loa (eye worm) DOMON domain-containing protein 0.0086 0.0478 0.1743
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.001 0.0009 0.0004
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0033 0.0153 0.1644
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.0025 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0645 0.2273
Treponema pallidum NADH oxidase 0.0036 0.0172 0.1836
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0025 0.0106 0.1326
Schistosoma mansoni zinc finger protein 0.0012 0.0025 0.0026
Onchocerca volvulus 0.0128 0.0736 0.2569
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.0758
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0172 0.2242
Onchocerca volvulus 0.0469 0.2836 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0065
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0172 0.1868
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0109 0.0375
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.001 0.0009 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.0758
Entamoeba histolytica hypothetical protein 0.0066 0.0354 0.389
Loa Loa (eye worm) hypothetical protein 0.0128 0.0736 0.2696
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.0758
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0075 0.0251
Brugia malayi hypothetical protein 0.0012 0.0025 0.0059
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0022 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0053
Schistosoma mansoni phosphoglycerate kinase 0.0089 0.0501 0.0666
Echinococcus multilocularis GPCR, family 2 0.004 0.0196 0.019
Brugia malayi Latrophilin receptor protein 2 0.004 0.0196 0.0691
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0106 0.1105
Mycobacterium tuberculosis Conserved protein 0.0128 0.0736 0.1465
Onchocerca volvulus 0.0086 0.0478 0.1659
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0072 0.0391 0.4377
Echinococcus granulosus expressed protein 0.0012 0.0022 0.0022
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.0025 0.0026
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.0025 0.0056
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0022 0.0077
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.03 0.0396
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0294 0.3923
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0012 0.0026 0.0232
Brugia malayi ecdysone receptor 0.0012 0.0025 0.0059
Echinococcus multilocularis dna polymerase eta 0.0034 0.0158 0.0152
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0151 0.0881 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0373 0.0495
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0109 0.0369
Trypanosoma cruzi trypanothione reductase, putative 0.0104 0.059 0.6662
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0034 0.0038
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0154 0.0896 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0056 0.0294 0.3267
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.001 0.0009 0.0005
Plasmodium falciparum thioredoxin reductase 0.0104 0.059 1
Trypanosoma brucei unspecified product 0.002 0.0075 0.0758
Loa Loa (eye worm) glutathione reductase 0.0104 0.059 0.2158
Schistosoma mansoni cpg binding protein 0.0036 0.0169 0.022
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0221 0.1308 0.4815
Loa Loa (eye worm) hypothetical protein 0.0026 0.0109 0.0375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0124 0.1316
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0109 0.0369
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.0022 0.0046
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.001 0.0009 0.0005
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.001 0.0009 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.027 0.1612 0.216
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0318 0.042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0294 0.3923
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0065
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0075 0.0758
Loa Loa (eye worm) hypothetical protein 0.0026 0.0109 0.0375
Trypanosoma cruzi polo-like protein kinase, putative 0.0113 0.0645 0.7286
Leishmania major mitochondrial DNA polymerase beta 0.0151 0.0881 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0109 0.0139
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0128 0.0736 0.0981
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0022 0.0077
Brugia malayi conserved hypotetical protein 0.0012 0.0025 0.0059
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0106 0.1105
Loa Loa (eye worm) programmed cell death 8 0.001 0.0009 0.0006
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0566 0.0754
Echinococcus multilocularis tar DNA binding protein 0.0058 0.0309 0.0304
Schistosoma mansoni hypothetical protein 0.0029 0.0129 0.0166
Loa Loa (eye worm) CXXC zinc finger family protein 0.0036 0.0169 0.0598
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.0025 0.002
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0172 0.1868
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0058 0.0309 0.1117
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0089 0.0501 0.1767
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0566 0.0561
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.0016
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0172 0.2242
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.0758
Onchocerca volvulus 0.0012 0.0022 0.0044
Entamoeba histolytica G protein alpha subunit, putative 0.0012 0.0022 0.0141
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0172 0.1868
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0237 0.141 0.2825
Trypanosoma brucei unspecified product 0.0014 0.0037 0.0313
Schistosoma mansoni hypothetical protein 0.0343 0.2063 0.2767
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.0022 0.0053
Loa Loa (eye worm) RNA binding protein 0.0058 0.0309 0.1117
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0031 0.0088
Echinococcus granulosus thioredoxin glutathione reductase 0.0105 0.0594 0.0791
Echinococcus multilocularis Niemann Pick C1 protein 0.007 0.0381 0.0376
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0109 0.0103
Brugia malayi tailless protein 0.0012 0.0025 0.0059
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.007 0.0381 0.4196
Trypanosoma brucei hypothetical protein, conserved 0.0128 0.0736 0.833
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0072 0.0859
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0021 0.008 0.0808
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.0758
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.0022 0.0022
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0044 0.022 0.0779
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0022 0.0046
Loa Loa (eye worm) thioredoxin reductase 0.0104 0.059 0.2158
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0109 0.0139
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0645 0.2273
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0172 0.1868
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0172 0.1868
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0448 0.2707 0.3633
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0037 0.0313
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.0025 0.0065
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0113 0.0385
Leishmania major cathepsin L-like protease 0.0028 0.0124 0.1316
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0075 0.0758
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0109 0.0139
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0021 0.008 0.0281
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0022 0.0077
Brugia malayi hypothetical protein 0.0066 0.0355 0.128
Brugia malayi CXXC zinc finger family protein 0.0036 0.0169 0.0592
Echinococcus multilocularis cpg binding protein 0.0039 0.0188 0.0182
Echinococcus granulosus sterol regulatory element binding protein 0.003 0.0135 0.0175
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0037 0.0102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0109 0.0375
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0172 0.1868
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.0025 0.0026
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0109 0.0353
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0645 0.0859
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.0022 0.0046
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0012 0.0026 0.019
Mycobacterium ulcerans esterase/lipase LipP 0.0128 0.0736 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0078 0.0428 0.0567
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0012 0.0022 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.027 0.1612 0.216
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0098
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0089 0.0501 1
Plasmodium vivax glutathione reductase, putative 0.0104 0.059 0.7998
Leishmania major DNA polymerase kappa, putative 0.002 0.0075 0.0758
Loa Loa (eye worm) hypothetical protein 0.004 0.0196 0.0696
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0109 0.0375
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0025 0.002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0158 0.0556
Echinococcus multilocularis zinc finger protein 0.0012 0.0026 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0065
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0172 0.0224
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0029 0.0132 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0124 0.1316
Loa Loa (eye worm) DR-78 0.0012 0.0025 0.0065
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.0025 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0124 0.1316
Onchocerca volvulus 0.0128 0.0736 0.2569
Schistosoma mansoni zinc finger protein 0.0012 0.0026 0.0028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0026 0.011 0.1154
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0022 0.0022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0318 0.0313
Onchocerca volvulus 0.0026 0.0109 0.0353
Echinococcus granulosus Niemann Pick C1 protein 0.007 0.0381 0.0505
Onchocerca volvulus 0.0036 0.0169 0.0566
Echinococcus multilocularis expressed protein 0.0012 0.0022 0.0016
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0172 0.331
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0098
Echinococcus granulosus phosphoglycerate kinase 1 0.0089 0.0501 0.0666
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.001 0.0009 0.0033
Leishmania major phosphoglycerate kinase C, glycosomal 0.0089 0.0501 0.5642
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0065
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.0025 0.0065
Brugia malayi nuclear receptor NHR-88 0.0026 0.0109 0.0369
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0109 0.0139
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.027 0.1612 0.216
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0172 0.2242
Treponema pallidum phosphoglycerate kinase 0.0089 0.0501 0.5546
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.0758
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0294 0.3923
Leishmania major cathepsin L-like protease 0.0028 0.0124 0.1316
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0126 0.0725 0.2659
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0037 0.0313
Brugia malayi hypothetical protein 0.0014 0.0034 0.0092
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0172 0.1868
Brugia malayi latrophilin 2 splice variant baaae 0.0086 0.048 0.1745
Loa Loa (eye worm) hypothetical protein 0.0026 0.0109 0.0375
Schistosoma mansoni kinase 0.0057 0.0303 0.04
Trypanosoma cruzi cruzipain precursor, putative 0.0028 0.0124 0.1316
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0109 0.0369
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0014 0.0036 0.003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0109 0.0103
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0309 0.0408
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0172 0.331
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0109 0.0103
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0109 0.0139
Loa Loa (eye worm) DOMON domain-containing protein 0.0086 0.0478 0.1743
Schistosoma mansoni hypothetical protein 0.001 0.0009 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0109 0.0139
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0089 0.0501 0.1767
Onchocerca volvulus 0.006 0.0318 0.1093
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0075 0.0413 0.2579
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0172 0.2803
Schistosoma mansoni sulfide quinone reductase 0.001 0.0009 0.0005
Trypanosoma cruzi major cysteine proteinase, putative 0.0022 0.0087 0.089
Echinococcus granulosus cpg binding protein 0.0039 0.0188 0.0245
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0053
Brugia malayi PHD-finger family protein 0.0015 0.0044 0.0127
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0033 0.0156 0.0151
Echinococcus granulosus expressed conserved protein 0.0066 0.0355 0.047
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.004 0.0196 0.0691
Loa Loa (eye worm) latrophilin receptor protein 2 0.004 0.0196 0.0696
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0109 0.0369
Loa Loa (eye worm) hypothetical protein 0.0037 0.0177 0.0628
Trypanosoma cruzi hypothetical protein, conserved 0.0128 0.0736 0.833
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0124 0.1316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0124 0.1316
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0012 0.0022 0.0077
Echinococcus multilocularis survival motor neuron protein 1 0.0174 0.1024 0.1019
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0172 0.0604
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0109 0.0139
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0075 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0318 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0124 0.1316
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0113 0.0645 0.2359
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0154 0.0896 0.316
Mycobacterium tuberculosis Probable oxidoreductase 0.0264 0.1573 0.3154
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0109 0.0369
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0294 0.1037
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.001 0.0009 0.0005
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.0022 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0025 0.0026
Mycobacterium ulcerans hypothetical protein 0.0128 0.0736 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.0025 0.0026
Toxoplasma gondii LsmAD domain-containing protein 0.0066 0.0355 0.4756
Loa Loa (eye worm) hypothetical protein 0.0126 0.0725 0.2659
Loa Loa (eye worm) beta-lactamase 0.0128 0.0736 0.2696
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0019 0.0067 0.0082
Mycobacterium tuberculosis Probable reductase 0.0237 0.141 0.2825
Onchocerca volvulus Serine\/threonine kinase homolog 0.0113 0.0645 0.2247
Brugia malayi DOMON domain containing protein 0.0086 0.0478 0.1738
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.004 0.0196 0.0255
Schistosoma mansoni inositol monophosphatase 0.0025 0.0106 0.0134
Echinococcus granulosus histone lysine methyltransferase setb 0.0069 0.0373 0.0495
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0237 0.141 0.2825
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.004 0.0196 0.0255
Trypanosoma brucei PAB1-binding protein , putative 0.0066 0.0355 0.3962
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0025 0.0026
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0075 0.0758
Brugia malayi serine/threonine-protein kinase plk-2 0.0113 0.0645 0.2355
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0172 0.1868
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0135 0.0478
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0645 0.2273
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0237 0.141 0.2825
Plasmodium vivax hypothetical protein, conserved 0.0128 0.0736 1
Brugia malayi beta-lactamase 0.0128 0.0736 0.2692
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0412 0.2486 0.9182
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0448 0.2707 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.0736 0.2696
Brugia malayi nuclear receptor NHR-67 0.0012 0.0025 0.0059
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0109 0.0369
Plasmodium vivax phosphoglycerate kinase, putative 0.0089 0.0501 0.6774
Brugia malayi hypothetical protein 0.0014 0.0034 0.0092
Loa Loa (eye worm) hypothetical protein 0.0128 0.0736 0.2696
Brugia malayi beta-lactamase family protein 0.0128 0.0736 0.2692
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0237 0.141 0.8958
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0373 0.0495
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0025 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0309 0.0408
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0009 0.0004
Echinococcus granulosus glutamate synthase 0.001 0.0009 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0154 0.0896 0.316
Trypanosoma brucei trypanothione reductase 0.0104 0.059 0.6662
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0172 0.2242
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0109 0.0369
Echinococcus granulosus dna polymerase eta 0.0034 0.0158 0.0205
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0318 0.4255
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0089 0.0501 0.6774
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.0277
Mycobacterium ulcerans phosphoglycerate kinase 0.0089 0.0501 0.6774
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0128 0.0736 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0075 0.0758
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.0025 0.0026
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0294 0.1037
Schistosoma mansoni glutamate synthase 0.001 0.0009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0066 0.0355 0.1286
Schistosoma mansoni peptidylglycine monooxygenase 0.0448 0.2707 0.3633
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0021 0.008 0.01
Plasmodium falciparum glutathione reductase 0.0036 0.0172 0.2803
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0022 0.0016
Leishmania major phosphopantetheinyl transferase-like protein 0.0012 0.0026 0.0193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.027 0.1612 0.216
Schistosoma mansoni transcription factor LCR-F1 0.0066 0.0354 0.0469
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0075 0.0094
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0113 0.0645 0.7286
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0109 0.0369
Onchocerca volvulus 0.0086 0.0478 0.1659
Schistosoma mansoni inositol monophosphatase 0.0025 0.0106 0.0134
Brugia malayi MH2 domain containing protein 0.0063 0.0337 0.1214
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0022 0.0022
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0056 0.0294 0.0289
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.027 0.1612 0.5941
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0025 0.0106 0.1326
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0034 0.0098
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0309 0.0408
Echinococcus granulosus L aminoadipate semialdehyde 0.0044 0.022 0.0288
Mycobacterium leprae conserved hypothetical protein 0.0128 0.0736 0.4646
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0172 0.1836
Brugia malayi hypothetical protein 0.0066 0.0354 0.1279
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0012 0.0026 0.0232
Echinococcus granulosus Protein patched homolog 1 0.003 0.0135 0.0175
Plasmodium falciparum glutathione reductase 0.0104 0.059 1
Echinococcus multilocularis sterol regulatory element binding protein 0.003 0.0135 0.013
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.0022 0.0046
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0109 0.0139
Loa Loa (eye worm) DOMON domain-containing protein 0.0086 0.0478 0.1743
Echinococcus multilocularis beta LACTamase domain containing family member 0.0128 0.0736 0.073
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0109 0.0139
Schistosoma mansoni sulfide quinone reductase 0.001 0.0009 0.0005
Echinococcus granulosus microtubule associated protein 2 0.1217 0.7443 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0075 0.0266
Trypanosoma cruzi cysteine peptidase, putative 0.0028 0.0124 0.1316
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.001 0.0009 0.0006
Onchocerca volvulus 0.0012 0.0025 0.0056
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0075 0.0094
Schistosoma mansoni DNA polymerase eta 0.0034 0.0158 0.0205
Echinococcus granulosus dnaJ subfamily B 0.0215 0.1274 0.1706
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0012 0.0026 0.0034
Schistosoma mansoni hypothetical protein 0.0029 0.0129 0.0166
Trypanosoma brucei phosphoglycerate kinase, putative 0.0033 0.0153 0.1644
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0065
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0021 0.008 0.0794
Echinococcus granulosus fetal alzheimer antigen falz 0.0014 0.0036 0.0041
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0034 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0124 0.1316
Giardia lamblia Fructose-bisphosphate aldolase 0.0154 0.0896 1
Trichomonas vaginalis D-aminoacylase, putative 0.0128 0.0736 0.2593
Leishmania major hypothetical protein, conserved 0.0128 0.0736 0.833
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.001 0.0009 0.0004
Echinococcus granulosus beta LACTamase domain containing family member 0.0128 0.0736 0.0981
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0113 0.0645 0.0859
Brugia malayi Inositol-1 0.0025 0.0106 0.0357
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0025 0.0106 0.1958
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0066 0.0354 0.389
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0227 0.1349 0.4967
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0075 0.0758
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0172 0.1868
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0109 0.0353
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.027 0.1612 0.5943
Echinococcus multilocularis protein patched 0.003 0.0135 0.013
Schistosoma mansoni hypothetical protein 0.0029 0.0129 0.0166
Trypanosoma brucei unspecified product 0.0014 0.0037 0.0313
Onchocerca volvulus 0.0036 0.0169 0.0565
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.0022 0.0046
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0158 0.055
Schistosoma mansoni glutamate synthase 0.001 0.0009 0.0005
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0022 0.0022
Schistosoma mansoni patched 1 0.003 0.0135 0.0175
Brugia malayi hypothetical protein 0.0042 0.0211 0.0749
Echinococcus multilocularis L aminoadipate semialdehyde 0.0044 0.022 0.0214
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0075 0.0245
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0012 0.0026 0.0232
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0021 0.0081 0.0826
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0065
Brugia malayi Bromodomain containing protein 0.002 0.0074 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.0758
Brugia malayi hypothetical protein 0.0012 0.0022 0.0046
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0021 0.008 0.0281
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0034 0.0092
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0072 0.0391 0.4377
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.004 0.0196 0.019
Entamoeba histolytica hypothetical protein 0.0066 0.0354 0.389
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0075 0.0133
Echinococcus granulosus ubiquitin specific protease 41 0.0021 0.008 0.01
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0113 0.0645 0.0639
Trichomonas vaginalis penicillin-binding protein, putative 0.0128 0.0736 0.2593
Giardia lamblia DINP protein human, muc B family 0.002 0.0075 0.0745
Schistosoma mansoni nuclear receptor 0.0012 0.0025 0.0026
Schistosoma mansoni hypothetical protein 0.004 0.0196 0.0255
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0012 0.0025 0.0056
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0172 0.2242
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0033 0.0153 0.1644
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0172 0.331
Schistosoma mansoni hypothetical protein 0.0343 0.2063 0.2767
Mycobacterium leprae Probable lipase LipE 0.0128 0.0736 0.4646
Brugia malayi ecdysteroid receptor 0.0026 0.0109 0.0369
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0056 0.0294 0.0388
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0022 0.0022
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0009 0.0033
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0021 0.008 0.0808
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0109 0.0139
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0448 0.2707 1
Echinococcus multilocularis dnaJ subfamily B 0.0215 0.1274 0.1269
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0309 0.0408
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0009 0.0033
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0012 0.0025 0.0059
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.0022 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0109 0.0375
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.0022 0.0022
Echinococcus multilocularis ubiquitin specific protease 41 0.0021 0.008 0.0074
Schistosoma mansoni hypothetical protein 0.004 0.0196 0.0255
Loa Loa (eye worm) hypothetical protein 0.0026 0.0109 0.0375
Plasmodium falciparum ataxin-2 like protein, putative 0.0066 0.0355 0.5947
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0448 0.2707 0.3633
Entamoeba histolytica hypothetical protein 0.0066 0.0354 0.389
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0089 0.0501 0.0992
Leishmania major DNA polymerase eta, putative 0.0034 0.0158 0.1703
Echinococcus granulosus tar DNA binding protein 0.0058 0.0309 0.0408
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0044 0.022 0.0288
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0109 0.0103
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0026 0.0109 0.1143
Onchocerca volvulus 0.0012 0.0025 0.0056
Mycobacterium tuberculosis Probable hydrolase 0.0128 0.0736 0.1465
Schistosoma mansoni microtubule-associated protein tau 0.1217 0.7443 1
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0022 0.0016
Loa Loa (eye worm) hypothetical protein 0.0174 0.1024 0.3764
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0033 0.0153 0.1644
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.0022 0.0022
Toxoplasma gondii thioredoxin reductase 0.0104 0.059 0.7998
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0012 0.0026 0.0232
Schistosoma mansoni hypothetical protein 0.0066 0.0354 0.0469
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0172 0.1868
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0075 0.0413 0.0813
Trichomonas vaginalis inositol monophosphatase, putative 0.0025 0.0106 0.0372
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.003 0.0135 0.0473
Leishmania major phosphoglycerate kinase B, cytosolic 0.0089 0.0501 0.5642
Brugia malayi Niemann-Pick C1 protein precursor 0.007 0.0381 0.138
Loa Loa (eye worm) hypothetical protein 0.0128 0.0736 0.2696
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0109 0.0375
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0109 0.0139
Trypanosoma brucei phosphoglycerate kinase 0.0033 0.0153 0.1644
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.001 0.0009 0.0005
Echinococcus granulosus sulfide:quinone oxidoreductase 0.001 0.0009 0.0005
Echinococcus granulosus survival motor neuron protein 1 0.0174 0.1024 0.1369
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0018 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.027 0.1612 0.216
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.0758
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0309 0.0408
Schistosoma mansoni coup transcription factor 0.0026 0.0109 0.0139
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0075 0.0094
Loa Loa (eye worm) hypothetical protein 0.0026 0.0109 0.0375
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0065
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.001 0.0009 0.0033
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.0025 0.002
Brugia malayi Bromodomain containing protein 0.0041 0.0206 0.0728
Schistosoma mansoni hypothetical protein 0.004 0.0196 0.0255
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0025 0.0026
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.027 0.1612 0.1607
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0065
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0128 0.0736 0.1465
Leishmania major cathepsin L-like protease 0.0028 0.0124 0.1316
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0023 0.0089 0.0512
Loa Loa (eye worm) hypothetical protein 0.0021 0.008 0.0267
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0012 0.0026 0.0232
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0022 0.0016
Leishmania major trypanothione reductase 0.0104 0.059 0.6662
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0022 0.0022
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0012 0.0026 0.0342
Brugia malayi Pre-SET motif family protein 0.0412 0.2486 0.9182
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0012 0.0022 0.0077
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0075 0.091
Loa Loa (eye worm) hypothetical protein 0.007 0.0381 0.1385
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.008 0.0281
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0025 0.0106 0.1105
Schistosoma mansoni disulfide oxidoreductase 0.001 0.0009 0.0005
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0172 0.2242
Trypanosoma brucei DNA polymerase eta, putative 0.0034 0.0158 0.1703
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0022 0.0046
Echinococcus multilocularis glutamate synthase 0.001 0.0009 0.0004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0034 0.0029
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0172 0.0224
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0109 0.0139
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0021 0.008 0.01
Trichomonas vaginalis D-aminoacylase, putative 0.0128 0.0736 0.2593
Echinococcus granulosus GPCR family 2 0.004 0.0196 0.0255
Echinococcus granulosus inositol monophosphatase 1 0.0025 0.0106 0.0134
Echinococcus multilocularis protein dispatched 1 0.0034 0.0162 0.0156
Treponema pallidum fructose-bisphosphate aldolase 0.0154 0.0896 1
Brugia malayi CHE-14 protein 0.003 0.0135 0.0468
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.027 0.1612 0.1607
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0089 0.0501 0.5642
Brugia malayi nuclear receptor RXR 0.0014 0.0034 0.0092
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0065
Brugia malayi follicle stimulating hormone receptor 0.0294 0.176 0.6488
Mycobacterium tuberculosis Conserved protein 0.0128 0.0736 0.1465
Schistosoma mansoni hypothetical protein 0.004 0.0196 0.0255
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0151 0.0881 1
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0109 0.0139
Loa Loa (eye worm) hypothetical protein 0.0026 0.0109 0.0375
Brugia malayi G-protein alpha subunit 0.0012 0.0022 0.0046
Loa Loa (eye worm) inositol-1 0.0025 0.0106 0.0363
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0053
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0264 0.1573 0.3154
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0109 0.0139
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0025 0.002
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0012 0.0026 0.029
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0031 0.0026
Trichomonas vaginalis disulfide oxidoreductase, putative 0.001 0.0009 0.0033
Loa Loa (eye worm) hypothetical protein 0.0026 0.0109 0.0375
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0158 0.1703
Toxoplasma gondii ABC1 family protein 0.0128 0.0736 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0172 0.1868
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0154 0.0896 0.316
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0645 0.2273
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0012 0.0026 0.0342
Echinococcus multilocularis thyroid hormone receptor alpha 0.0026 0.0109 0.0103
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0109 0.0103
Schistosoma mansoni dopamine-beta-monooxygenase 0.0848 0.517 0.6944
Plasmodium falciparum ataxin-2 like protein, putative 0.0066 0.0355 0.5947
Trichomonas vaginalis set domain proteins, putative 0.0469 0.2836 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.0758
Schistosoma mansoni phosphoglycerate kinase 0.0089 0.0501 0.0666
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0021 0.008 0.0808
Plasmodium falciparum thioredoxin reductase 0.0036 0.0172 0.2803
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0022 0.0022
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0109 0.0375
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0033 0.0153 0.1644
Plasmodium falciparum phosphoglycerate kinase 0.0089 0.0501 0.8469
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0029 0.0132 0.0126
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0021 0.008 0.01
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0021 0.008 0.01
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0075 0.0266
Trypanosoma brucei phosphoglycerate kinase 0.0089 0.0501 0.5642
Echinococcus multilocularis dna polymerase kappa 0.002 0.0075 0.007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0109 0.0139
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0154 0.0896 0.316
Plasmodium vivax thioredoxin reductase, putative 0.0104 0.059 0.7998
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0154 0.0896 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0021 0.008 0.0074
Schistosoma mansoni glutamate synthase 0.001 0.0009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0053
Echinococcus granulosus zinc finger protein 0.0012 0.0026 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.0758
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0021 0.0081 0.0826
Loa Loa (eye worm) hypothetical protein 0.0448 0.2707 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0105 0.0594 0.0589
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0025 0.002
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0011 0.0018 0.0012
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0022 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0028 0.0124 0.1316
Leishmania major hypothetical protein, conserved 0.0066 0.0355 0.3962
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0109 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0034 0.0092
Brugia malayi Phosphoglycerate kinase 0.0033 0.0153 0.0531
Brugia malayi TAR-binding protein 0.0058 0.0309 0.1111
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0815 0.4966 1
Trichomonas vaginalis esterase, putative 0.0128 0.0736 0.2593
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0109 0.0369
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0012 0.0022 0.0077
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0021 0.008 0.0794
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0109 0.0369
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0248
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0065
Entamoeba histolytica hypothetical protein 0.0012 0.0026 0.019
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.001 0.0009 0.0033
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0172 0.0607
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0645 0.2273
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0012 0.0022 0.0077
Brugia malayi beta-lactamase family protein 0.0128 0.0736 0.2692
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0172 0.1868
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0022 0.0022
Chlamydia trachomatis phosphoglycerate kinase 0.0089 0.0501 1
Trypanosoma cruzi hypothetical protein, conserved 0.0128 0.0736 0.833
Trichomonas vaginalis apoptosis inducing factor, putative 0.001 0.0009 0.0033
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0294 0.0388
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0022 0.0022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0128 0.0736 0.1465
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0037 0.0313
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0089 0.0501 0.3147
Schistosoma mansoni cpg binding protein 0.0039 0.0188 0.0245
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0089 0.0501 0.5642
Schistosoma mansoni nuclear receptor 0.0012 0.0025 0.0026
Brugia malayi DOMON domain containing protein 0.0086 0.0478 0.1738
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0075 0.0745
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0066 0.0354 0.0349
Brugia malayi nuclear receptor NHR-88 0.0012 0.0025 0.0059
Echinococcus multilocularis expressed conserved protein 0.0066 0.0355 0.035
Loa Loa (eye worm) PHD-finger family protein 0.0011 0.0017 0.0036
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0237 0.141 0.2825
Onchocerca volvulus 0.0128 0.0736 0.2569
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0018 0.0012
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0172 0.0167
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0033 0.0153 0.1644
Mycobacterium tuberculosis Conserved hypothetical protein 0.008 0.0441 0.087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0126 0.0725 0.2654
Loa Loa (eye worm) hypothetical protein 0.0037 0.0179 0.0636
Trichomonas vaginalis glutamate synthase, putative 0.001 0.0009 0.0033
Loa Loa (eye worm) TAR-binding protein 0.0058 0.0309 0.1117
Brugia malayi Calcitonin receptor-like protein seb-1 0.0126 0.0725 0.2654
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0109 0.0139
Brugia malayi Phosphoglycerate kinase 0.0089 0.0501 0.1823
Loa Loa (eye worm) hypothetical protein 0.0128 0.0736 0.2696
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0104 0.059 0.1172
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.0025 0.0065
Toxoplasma gondii aldehyde dehydrogenase 0.0056 0.0294 0.3923
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0448 0.2707 0.2703
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0172 0.0329
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.001 0.0009 0.0004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0128 0.0736 0.1465
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0172 0.1868
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0172 0.0607
Mycobacterium tuberculosis Conserved protein 0.0128 0.0736 0.1465
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0294 0.176 0.649
Mycobacterium tuberculosis Probable lipase LipD 0.0128 0.0736 0.1465

Activities

Activity type Activity value Assay description Source Reference
-Log IC50 (binding) = 5.25 Inhibition of dopamine beta hydroxylase ChEMBL. 7783140
-Log IC50 (binding) = 5.25 Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally ChEMBL. 2296023
Decrease (functional) ND 0 mM Mean arterial blood pressure at 4 h post drug at ip dose of 50 mg/kg for the indicated number of SHR (spontaneous hypertensive rats) relative to blood pressure before dosing;ND is defined as no-data ChEMBL. 3820219
Decrease (functional) ND 0 mM Mean arterial blood pressure at 4 h post drug at po dose of 50 mg/kg for the indicated number of SHR (spontaneous hypertensive rats) relative to blood pressure before dosing;ND is defined as no-data ChEMBL. 3820219
IC50 (binding) = 5.25 Inhibition of dopamine beta hydroxylase ChEMBL. 7783140
IC50 (binding) = 5.25 Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally ChEMBL. 2296023
IC50 (binding) = 5.25 Inhibition of dopamine beta-hydroxylase (DbetaH) enzyme ChEMBL. 9435905
IC50 (binding) = 5.6 uM Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH) ChEMBL. 2299645
IC50 (binding) = 5.6 uM Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (4.9-6.5) ChEMBL. 3820219
IC50 (binding) = 5.6 uM Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH) ChEMBL. 2299645
IC50 (binding) = 5.6 uM Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (4.9-6.5) ChEMBL. 3820219
Increase (functional) = 364 % Change in DA/NE (Dopamine/Norepinephrine) ratio after oral dosing (50 mg/kg) ChEMBL. 3820219
Kis (binding) ND 0 uM Inhibitor dissociation constant vs. tyramine substrate against Dopamine beta hydroxylase at pH 6.0;ND is defined as no-data. ChEMBL. 3820219
Kis (binding) ND 0 uM Inhibitor dissociation constant vs. tyramine substrate against Dopamine beta hydroxylase at pH 6.6;ND is defined as no-data. ChEMBL. 3820219
Kis (binding) = 0.108 uM Inhibitor dissociation constant vs. tyramine substrate against Dopamine beta hydroxylase at pH 4.5. ChEMBL. 3820219
Kis (binding) = 0.108 uM Inhibitor dissociation constant vs. tyramine substrate against Dopamine beta hydroxylase at pH 4.5. ChEMBL. 3820219
logP (ADMET) = 1.7 Partition coefficient (logP) ChEMBL. 3820219

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

5 literature references were collected for this gene.

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