Detailed information for compound 1069352

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 429.936 | Formula: C24H28ClNO4
  • H donors: 1 H acceptors: 1 LogP: 5.03 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CC1(C)OOC2(C1)CCCCC2)NCc1cccc(c1)Oc1ccc(cc1)Cl
  • InChi: 1S/C24H28ClNO4/c1-23(17-24(30-29-23)12-3-2-4-13-24)15-22(27)26-16-18-6-5-7-21(14-18)28-20-10-8-19(25)9-11-20/h5-11,14H,2-4,12-13,15-17H2,1H3,(H,26,27)
  • InChiKey: UGFNICCLSQNUSD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0119 0.024 0.024
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.003 0.003
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0071 0.7508
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0006
Echinococcus multilocularis musashi 0.0057 0.0104 0.0104
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0119 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.003 0.0101
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.003 0.003
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0013 0.1206
Plasmodium vivax vivapain-2 0.0018 0.0019 0.1787
Plasmodium vivax vivapain-2 0.0018 0.0019 0.1787
Schistosoma mansoni hypothetical protein 0.0296 0.0629 0.0629
Onchocerca volvulus Peroxidasin homolog 0.0915839 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0102 0.0343
Onchocerca volvulus 0.0059 0.0108 0.0358
Schistosoma mansoni septate junction protein 0.0296 0.0629 0.0629
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0011 0.0083
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0003 0.0003
Brugia malayi ecdysteroid receptor 0.0023 0.003 0.0101
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0122 0.0248 0.1801
Loa Loa (eye worm) hypothetical protein 0.0089 0.0175 0.0591
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Echinococcus granulosus notch 0.0296 0.0629 0.0629
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0081 1
Loa Loa (eye worm) hypothetical protein 0.0375 0.0802 0.2729
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0054 0.0405
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.0315 0.0315
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0122 0.0248 0.8878
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0013 0.0098
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.003 0.003
Echinococcus granulosus delta-like protein 1 0.0296 0.0629 0.0629
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0019 0.2388
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0046 0.0153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0293 0.0293
Onchocerca volvulus 0.0032 0.0051 0.0162
Loa Loa (eye worm) animal heme peroxidase 0.1348 0.2937 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.003 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.003 0.0101
Echinococcus granulosus cathepsin l1 0.0018 0.0019 0.0019
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0054 0.5648
Echinococcus granulosus cathepsin l1 0.0012 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Onchocerca volvulus 0.0012 0.0006 0.001
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0013 0.0033
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0123
Entamoeba histolytica cysteine protease, putative 0.0018 0.0019 0.203
Brugia malayi nuclear hormone receptor 0.0011 0.0003 0.0011
Echinococcus granulosus lamin dm0 0.0057 0.0104 0.0104
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0044 0.0328
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Schistosoma mansoni slit 0.0296 0.0629 0.0629
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.003 0.0101
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0003 0.0003
Brugia malayi hypothetical protein 0.0037 0.006 0.0204
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0006
Echinococcus multilocularis tumor protein p63 0.0719 0.1557 0.1557
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0044 0.4031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0015
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0003 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0131 0.0989
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0131 0.0989
Plasmodium falciparum LCCL domain-containing protein 0.0059 0.0108 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Brugia malayi Calcium binding EGF domain containing protein 0.0296 0.0629 0.2141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0293 0.0293
Toxoplasma gondii cathepsin CPL 0.0018 0.0019 0.0135
Echinococcus multilocularis neurogenic locus notch protein 4 0.0296 0.0629 0.0629
Echinococcus multilocularis L aminoadipate semialdehyde 0.0188 0.0391 0.0391
Echinococcus multilocularis thyroid hormone receptor alpha 0.0166 0.0344 0.0344
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0094 0.0321
Onchocerca volvulus 0.0188 0.0391 0.1322
Schistosoma mansoni thyroid hormone receptor 0.0166 0.0344 0.0344
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0071 0.0538
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0019 0.1787
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0019 0.0066
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0013 0.0044
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0097 0.8991
Echinococcus multilocularis lamin 0.0057 0.0104 0.0104
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0081 0.7483
Onchocerca volvulus Peroxidasin homolog 0.1348 0.2937 1
Entamoeba histolytica hypothetical protein 0.0037 0.006 0.6304
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.002 0.0153
Leishmania major trypanothione reductase 0.0054 0.0097 0.0655
Brugia malayi Calcium binding EGF domain containing protein 0.0296 0.0629 0.2141
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Schistosoma mansoni hypothetical protein 0.0296 0.0629 0.0629
Brugia malayi Latrophilin receptor protein 2 0.0119 0.024 0.0817
Onchocerca volvulus 0.1348 0.2937 1
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0019 0.203
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.003 0.0101
Schistosoma mansoni hypothetical protein 0.0052 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0096
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0119 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Schistosoma mansoni notch 0.0296 0.0629 0.0629
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0053 0.0095 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0019 0.2388
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.002 0.1875
Onchocerca volvulus 0.0018 0.0019 0.0055
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0131 0.0989
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0019 0.0066
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0104 0.0355
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0019 0.0019
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0003 0.0003
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0615 0.1328 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0053 0.0095 0.8801
Plasmodium vivax glutathione reductase, putative 0.0054 0.0097 0.8991
Onchocerca volvulus 0.0296 0.0629 0.2132
Onchocerca volvulus 0.0059 0.0108 0.0358
Brugia malayi hypothetical protein 0.0011 0.0003 0.0011
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0003 0.0003
Brugia malayi Cathepsin L-like precursor 0.0018 0.0019 0.0066
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.0293 0.0994
Onchocerca volvulus Peroxidase homolog 0.0915839 0.5 0.5
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0013 0.1206
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Brugia malayi hypothetical protein 0.0059 0.0108 0.0368
Onchocerca volvulus Dual oxidase homolog 0.0915839 0.5 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.003 0.0096
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0054 0.0405
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0071 0.0538
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0006
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0013 0.0013
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.002 0.002
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0296 0.0629 0.2132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0131 0.0989
Echinococcus granulosus cpg binding protein 0.0034 0.0055 0.0055
Leishmania major cathepsin L-like protease 0.0069 0.0131 0.0914
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0046 0.0158
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.002 0.0069
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0001 0.0001
Brugia malayi Cytochrome P450 family protein 0.0014 0.0011 0.0037
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0026 0.2404
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0026 0.0196
Onchocerca volvulus 0.0057 0.0104 0.0345
Loa Loa (eye worm) cysteine protease 0.0018 0.0019 0.0061
Brugia malayi EGF-like domain containing protein 0.0296 0.0629 0.2141
Echinococcus multilocularis notch 0.0296 0.0629 0.0629
Echinococcus multilocularis neurogenic locus protein delta 0.0296 0.0629 0.0629
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0071 0.0459
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0013 0.0098
Brugia malayi nuclear receptor RXR 0.0011 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0019 0.2388
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0081 0.0081
Brugia malayi Peroxidasin 0.0915839 0.5 0.5
Leishmania major basic transcription factor 3a, putative 0.0034 0.0054 0.0325
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0073 0.0858
Schistosoma mansoni cellular tumor antigen P53 0.0105 0.021 0.021
Echinococcus granulosus lamin 0.0057 0.0104 0.0104
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0097 0.0733
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.002 0.0153
Echinococcus granulosus fibropellin Ia 0.0296 0.0629 0.0629
Trypanosoma brucei cytochrome P450, putative 0.0014 0.0011 0.0083
Loa Loa (eye worm) hypothetical protein 0.0256 0.0542 0.1842
Brugia malayi Animal haem peroxidase family protein 0.0915839 0.5 0.5
Schistosoma mansoni coup transcription factor 0.0023 0.003 0.003
Brugia malayi Cathepsin L-like precursor 0.0018 0.0019 0.0066
Leishmania major cathepsin L-like protease 0.0018 0.0019 0.0063
Schistosoma mansoni hypothetical protein 0.0296 0.0629 0.0629
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0053 0.0095 0.064
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0013 0.0013
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0097 0.0097
Brugia malayi Animal haem peroxidase family protein 0.0915839 0.5 0.5
Echinococcus multilocularis neuropeptide s receptor 0.1478 0.3222 0.3222
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.002 0.0153
Schistosoma mansoni lamin 0.0057 0.0104 0.0104
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0054 0.0405
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0053 0.0095 1
Brugia malayi tailless protein 0.0011 0.0003 0.0011
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0019 0.0019
Brugia malayi Calcium binding EGF domain containing protein 0.0296 0.0629 0.2141
Brugia malayi Inositol-1 0.0042 0.0071 0.0243
Brugia malayi hypothetical protein 0.1348 0.2937 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0019 0.0066
Echinococcus granulosus protein jagged 1 0.0296 0.0629 0.0629
Brugia malayi Animal haem peroxidase family protein 0.0915839 0.5 0.5
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0026 0.0114
Plasmodium falciparum thioredoxin reductase 0.0019 0.002 0.1875
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0003 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Schistosoma mansoni cpg binding protein 0.0032 0.0051 0.0051
Brugia malayi Cathepsin L-like precursor 0.0018 0.0019 0.0066
Leishmania major cathepsin L-like protease 0.0069 0.0131 0.0914
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0073 0.7614
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0351 0.075 0.075
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0001 0.0004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0013 0.0013
Loa Loa (eye worm) animal heme peroxidase 0.0915839 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0019 0.2388
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0054 0.6643
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0296 0.0629 0.0629
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0019 0.0019
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0044 0.0328
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0001 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.003 0.003
Trypanosoma cruzi cytochrome P450, putative 0.0014 0.0011 0.0083
Leishmania major cathepsin L-like protease 0.0069 0.0131 0.0914
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0026 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0006 0.076
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0096
Brugia malayi GCC2 and GCC3 family protein 0.0296 0.0629 0.2141
Entamoeba histolytica hypothetical protein 0.0034 0.0054 0.5648
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0026 0.2732
Schistosoma mansoni peroxidasin 0.0915839 0.5 0.5
Schistosoma mansoni hypothetical protein 0.0348 0.0743 0.0743
Trypanosoma brucei hypothetical protein, conserved 0.0053 0.0095 0.0717
Echinococcus multilocularis peroxidasin 0.1348 0.2937 0.2937
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Echinococcus multilocularis protein jagged 1 0.0296 0.0629 0.0629
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0053 0.0095 0.1364
Onchocerca volvulus Putative cubilin 0.0296 0.0629 0.2132
Leishmania major cathepsin L-like protease 0.0018 0.0019 0.0063
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.003 0.003
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0044 0.0528
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0014 0.0009 0.0032
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0257 0.0543 0.1844
Echinococcus granulosus neuropeptide s receptor 0.1478 0.3222 0.3222
Echinococcus multilocularis neurogenic locus protein delta 0.0296 0.0629 0.0629
Brugia malayi EGF-like domain containing protein 0.0296 0.0629 0.2141
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0006
Echinococcus granulosus transcription factor btf3 0.0034 0.0054 0.0054
Brugia malayi isocitrate dehydrogenase 0.0015 0.0013 0.0044
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0071 0.0538
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0026 0.0089
Giardia lamblia High cysteine protein 0.0296 0.0629 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.002 0.0153
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0097 0.0326
Onchocerca volvulus Phospholipase A2 homolog 0.0089 0.0175 0.0585
Brugia malayi Muscle positioning protein 4 0.0296 0.0629 0.2141
Schistosoma mansoni cpg binding protein 0.0034 0.0055 0.0055
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Echinococcus granulosus FTZ F1 alpha 0.0023 0.003 0.003
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0006 0.0646
Onchocerca volvulus Chorion peroxidase homolog 0.0915839 0.5 0.5
Brugia malayi conserved hypotetical protein 0.0011 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0054 0.6643
Schistosoma mansoni survival motor neuron protein 0.0052 0.0094 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Schistosoma mansoni thyroid hormone receptor 0.0166 0.0344 0.0344
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0003 0.0003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.002 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.002 0.0153
Schistosoma mansoni peroxidasin 0.0915839 0.5 0.5
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0071 0.8831
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0029 0.0044 0.0248
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0006 0.0021
Brugia malayi EGF-like domain containing protein 0.0296 0.0629 0.2141
Plasmodium falciparum glutathione reductase 0.0019 0.002 0.1875
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.002 0.0071
Schistosoma mansoni inositol monophosphatase 0.0042 0.0071 0.0071
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0013 0.0016
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.003 0.009
Echinococcus multilocularis fat cadherin tumor suppressor 0.0296 0.0629 0.0629
Entamoeba histolytica hypothetical protein 0.0037 0.006 0.6304
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0006
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0003 0.0011
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0351 0.075 0.075
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.002 0.0071
Echinococcus multilocularis protein jagged 2 0.0296 0.0629 0.0629
Brugia malayi beta-NAC-like protein 0.0034 0.0054 0.0183
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.003 0.0101
Loa Loa (eye worm) doublecortin family protein 0.0059 0.0108 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.003 0.0101
Brugia malayi Animal haem peroxidase family protein 0.0915839 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0136 0.0278 0.2029
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Schistosoma mansoni lipoxygenase 0.0245 0.0518 0.0518
Echinococcus granulosus Polycystic kidney disease protein 0.0059 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0006
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0019 0.203
Echinococcus granulosus neurogenic locus protein delta 0.0296 0.0629 0.0629
Onchocerca volvulus 0.0018 0.0019 0.0055
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0003 0.0003
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0013 0.0098
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0375 0.0802 0.2732
Echinococcus granulosus neurogenic locus notch protein 0.0296 0.0629 0.0629
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0071 0.0459
Echinococcus multilocularis cysteine protease 0.0018 0.0019 0.0019
Brugia malayi glutathione reductase 0.0054 0.0097 0.0331
Schistosoma mansoni notch 0.0296 0.0629 0.0629
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0011 0.0083
Brugia malayi hypothetical protein 0.0915839 0.5 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0915839 0.5 0.5
Echinococcus multilocularis GPCR, family 2 0.0119 0.024 0.024
Brugia malayi nuclear receptor RXR 0.0012 0.0006 0.002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.002 0.0153
Trypanosoma brucei trypanothione reductase 0.0054 0.0097 0.0733
Onchocerca volvulus 0.0105 0.021 0.0706
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.003 0.003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0119 0.024 0.0812
Onchocerca volvulus 0.0018 0.0019 0.0055
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0019 0.0019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.0293 0.0998
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0013 0.0013
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0011 0.0032
Echinococcus multilocularis peroxidasin 0.0915839 0.5 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0131 0.0989
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0044 0.0328
Echinococcus multilocularis neurogenic locus notch protein 0.0296 0.0629 0.0629
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0019 0.0146
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0131 0.0989
Schistosoma mansoni nuclear receptor 0.0011 0.0003 0.0003
Schistosoma mansoni notch 0.0296 0.0629 0.0629
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0136 0.0278 0.2029
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0096
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0006
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.002 0.1875
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0019 0.2388
Echinococcus multilocularis lamin dm0 0.0057 0.0104 0.0104
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.0325 0.0325
Echinococcus granulosus tumor protein p63 0.0719 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Loa Loa (eye worm) inositol-1 0.0042 0.0071 0.0239
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0071 0.098
Schistosoma mansoni polycystin 1-related 0.0059 0.0108 0.0108
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0011 0.0032
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0019 0.002 0.0151
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0003 0.0003
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0131 0.0989
Loa Loa (eye worm) hypothetical protein 0.0105 0.021 0.0712
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0615 0.1328 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.002 0.0153
Loa Loa (eye worm) animal heme peroxidase 0.0915839 0.5 0.5
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.4323 0.9465 0.9465
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0026 0.0094
Onchocerca volvulus 0.0296 0.0629 0.2132
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0293 0.0293
Schistosoma mansoni loxhd1 0.0059 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0059 0.0108 0.0364
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.004 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.003 0.0096
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0057 0.0104 0.0351
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0053 0.0095 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0108 0.0108
Onchocerca volvulus Peroxidase homolog 0.1348 0.2937 1
Echinococcus multilocularis RUN 0.0059 0.0108 0.0108
Schistosoma mansoni lamin 0.0057 0.0104 0.0104
Entamoeba histolytica hypothetical protein 0.0037 0.006 0.6304
Brugia malayi Cytochrome P450 family protein 0.0014 0.0011 0.0037
Echinococcus multilocularis cysteine protease 0.0018 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0096
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0073 0.6701
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0013 0.0013
Schistosoma mansoni peroxidasin 0.1348 0.2937 0.2937
Onchocerca volvulus Peroxidase homolog 0.0915839 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0006
Brugia malayi cytochrome P450 0.0014 0.0011 0.0037
Onchocerca volvulus 0.0296 0.0629 0.2132
Echinococcus multilocularis slit 2 protein 0.0296 0.0629 0.0629
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0013 0.0013
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0003 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.003 0.0096
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.0325 0.0325
Echinococcus granulosus neurogenic locus notch protein 0.0296 0.0629 0.0629
Onchocerca volvulus 0.0915839 0.5 0.5
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0003 0.0003
Brugia malayi Thioredoxin reductase 0.0054 0.0097 0.0331
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.003 0.003
Brugia malayi latrophilin 2 splice variant baaae 0.0256 0.0542 0.1846
Echinococcus granulosus geminin 0.0348 0.0743 0.0743
Schistosoma mansoni hypothetical protein 0.0119 0.024 0.024
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0054 0.0693
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0003 0.0011
Onchocerca volvulus 0.0023 0.003 0.009
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0026 0.3213
Onchocerca volvulus Phospholipase A2 homolog 0.0089 0.0175 0.0585
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Onchocerca volvulus Peroxidase homolog 0.1348 0.2937 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0143 0.0294 0.0294
Schistosoma mansoni rab6-interacting 0.0059 0.0108 0.0108
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0081 0.1133
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0293 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0131 0.0989
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0026 0.0114
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0081 0.1133
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0026 0.0114
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0096
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0118 0.089
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0375 0.0802 0.2729
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Onchocerca volvulus 0.0057 0.0104 0.0345
Schistosoma mansoni nuclear hormone receptor 0.0023 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0037 0.006 0.6304
Brugia malayi EGF-like domain containing protein 0.0296 0.0629 0.2141
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0019 0.0055
Onchocerca volvulus Chorion peroxidase homolog 0.1348 0.2937 1
Echinococcus multilocularis 0.0014 0.0011 0.0011
Brugia malayi Cytochrome P450 family protein 0.0014 0.0011 0.0037
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.003 0.003
Brugia malayi Blistered cuticle protein 3 0.0915839 0.5 0.5
Schistosoma mansoni hypothetical protein 0.0037 0.006 0.006
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0071 0.8831
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0019 0.0061
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0026 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.003 0.0101
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0026 0.0084
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0053 0.0095 0.064
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.006 0.006
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0233 0.079
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0081 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.003 0.0096
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0122 0.0248 0.1801
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.006 0.006
Brugia malayi hypothetical protein 0.0012 0.0006 0.002
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0062 0.1904
Loa Loa (eye worm) animal heme peroxidase 0.0915839 0.5 0.5
Schistosoma mansoni hypothetical protein 0.0256 0.0542 0.0542
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0019 0.0061
Trichomonas vaginalis glutathione reductase, putative 0.0019 0.002 0.2506
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0019 0.0055
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.003 0.003
Echinococcus multilocularis transcription factor btf3 0.0034 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Loa Loa (eye worm) animal heme peroxidase 0.1348 0.2937 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0233 0.079
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0054 0.6643
Brugia malayi EGF-like domain containing protein 0.0296 0.0629 0.2141
Brugia malayi Animal haem peroxidase family protein 0.1348 0.2937 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Brugia malayi Animal haem peroxidase family protein 0.1348 0.2937 1
Schistosoma mansoni notch 0.0296 0.0629 0.0629
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0131 0.0989
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.003 0.003
Brugia malayi Animal haem peroxidase family protein 0.0915839 0.5 0.5
Schistosoma mansoni intermediate filament proteins 0.0057 0.0104 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.003 0.0096
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0029 0.0044 0.0144
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0013 0.0039
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0011 0.0011
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0104 0.0351
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0122 0.0248 0.1801
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0006 0.0006
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0003 0.0006
Toxoplasma gondii exonuclease III APE 0.0021 0.0026 0.0243
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0006 0.0006
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0019 0.2388
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0123
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0143 0.0294 0.0294
Echinococcus multilocularis protein jagged 1 0.0296 0.0629 0.0629
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0019 0.0019
Onchocerca volvulus Peroxidasin homolog 0.0915839 0.5 0.5
Brugia malayi steroid hormone receptor 0.0023 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0015
Onchocerca volvulus 0.0296 0.0629 0.2132
Echinococcus granulosus neurogenic locus notch protein 4 0.0296 0.0629 0.0629
Toxoplasma gondii NADPH-glutathione reductase 0.0019 0.002 0.0151
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0019 0.2388
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0097 0.0097
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0099 0.0744
Onchocerca volvulus Dual oxidase homolog 0.1348 0.2937 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0003 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0011 0.0032
Onchocerca volvulus 0.0052 0.0094 0.0311
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0296 0.0629 0.2141
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0019 0.0019
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0018 0.0019 0.0055
Brugia malayi MH2 domain containing protein 0.0116 0.0233 0.0794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.0108 0.0108
Trichomonas vaginalis mercuric reductase, putative 0.0019 0.002 0.2506
Brugia malayi cathepsin L-like precursor 0.0012 0.0006 0.0021
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0059 0.0108 0.0108
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.002 0.0071
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0096
Echinococcus multilocularis neurogenic locus notch protein 0.0296 0.0629 0.0629
Schistosoma mansoni hypothetical protein 0.0296 0.0629 0.0629
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.003 0.0101
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.003 0.0101
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0008 0.0008
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0615 0.1328 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0019 0.2388
Loa Loa (eye worm) blistered cuticle protein 3 0.1348 0.2937 1
Brugia malayi Animal haem peroxidase family protein 0.1348 0.2937 1
Echinococcus granulosus protein jagged 2 0.0296 0.0629 0.0629
Echinococcus granulosus peroxidasin 0.1348 0.2937 0.2937
Schistosoma mansoni ap endonuclease 0.0021 0.0026 0.0026
Echinococcus granulosus protein jagged 1 0.0296 0.0629 0.0629
Echinococcus granulosus GPCR family 2 0.0119 0.024 0.024
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.0325 0.1105
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0006
Brugia malayi hypothetical protein 0.0059 0.0108 0.0368
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.002 0.0153
Onchocerca volvulus 0.0018 0.0019 0.0055
Brugia malayi Cathepsin L-like precursor 0.0012 0.0006 0.0021
Echinococcus granulosus L aminoadipate semialdehyde 0.0188 0.0391 0.0391
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0044 0.4031
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Schistosoma mansoni hypothetical protein 0.0143 0.0294 0.0294
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0003 0.0011
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0019 0.0055
Schistosoma mansoni hypothetical protein 0.0296 0.0629 0.0629
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0136 0.0278 1
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0019 0.0063
Brugia malayi Cathepsin L-like precursor 0.0012 0.0006 0.0021
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0188 0.0391 0.0391
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.003 0.0101
Loa Loa (eye worm) glutathione reductase 0.0054 0.0097 0.0326
Loa Loa (eye worm) fibroinase 0.0018 0.0019 0.0061
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.006 0.006
Brugia malayi Animal haem peroxidase family protein 0.1348 0.2937 1
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0003 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.013 0.013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0003 0.0003
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0131 0.0989
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0131 0.0989
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0096
Onchocerca volvulus 0.0296 0.0629 0.2132
Brugia malayi CXXC zinc finger family protein 0.0032 0.0051 0.0172
Plasmodium falciparum thioredoxin reductase 0.0054 0.0097 0.8991
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.0293 0.0293
Echinococcus multilocularis neuropeptide receptor A26 0.1478 0.3222 0.3222
Loa Loa (eye worm) hypothetical protein 0.0018 0.0019 0.0061
Echinococcus granulosus protein jagged 2 0.0296 0.0629 0.0629
Loa Loa (eye worm) hypothetical protein 0.0119 0.024 0.0812
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.0293 0.0293
Schistosoma mansoni hypothetical protein 0.0119 0.024 0.024
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0051 0.0167
Leishmania major cathepsin L-like protease 0.0018 0.0019 0.0063
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0026 0.0764
Brugia malayi Blistered cuticle protein 3 0.1348 0.2937 1
Brugia malayi nuclear receptor NHR-67 0.0011 0.0003 0.0011
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0003 0.0011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.003 0.003
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0188 0.0391 0.1332
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0123 0.1807
Mycobacterium tuberculosis Probable reductase 0.0122 0.0248 0.1801
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.003 0.009
Leishmania major cathepsin L-like protease 0.0018 0.0019 0.0063
Brugia malayi Cadherin domain containing protein 0.0296 0.0629 0.2141
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0003 0.0003
Leishmania major cathepsin L-like protease 0.0018 0.0019 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.003 0.003
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0071 0.8831
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0013 0.0013
Onchocerca volvulus Neurogenic locus notch homolog 0.0296 0.0629 0.2132
Schistosoma mansoni cytochrome P450 0.0014 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0096
Brugia malayi intermediate filament protein 0.0057 0.0104 0.0355
Brugia malayi nuclear receptor NHR-88 0.0011 0.0003 0.0011
Mycobacterium leprae conserved hypothetical protein 0.0053 0.0095 0.3153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.003 0.0096
Leishmania major phosphopantetheinyl transferase-like protein 0.0053 0.0095 0.064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.002 0.0153
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.003 0.003
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.002 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.003 0.0096
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.003 0.003
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0003 0.0003
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0122 0.0248 0.1801
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0006 0.0006
Schistosoma mansoni transcription factor btf3 0.0034 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.003 0.003
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0108 0.0108
Schistosoma mansoni notch 0.0296 0.0629 0.0629
Schistosoma mansoni inositol monophosphatase 0.0042 0.0071 0.0071
Brugia malayi nuclear receptor NHR-88 0.0023 0.003 0.0101
Echinococcus multilocularis geminin 0.0348 0.0743 0.0743
Brugia malayi notch-like transmembrane receptor 0.0296 0.0629 0.2141
Schistosoma mansoni ap endonuclease 0.0021 0.0026 0.0026
Onchocerca volvulus 0.1348 0.2937 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0615 0.1328 1
Toxoplasma gondii thioredoxin reductase 0.0054 0.0097 0.1397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0006 0.076
Echinococcus granulosus survival motor neuron protein 1 0.0257 0.0543 0.0543
Onchocerca volvulus 0.0915839 0.5 0.5
Brugia malayi hypothetical protein 0.0012 0.0006 0.002
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0615 0.1328 1
Onchocerca volvulus 0.0018 0.0019 0.0055
Loa Loa (eye worm) cytochrome P450 0.0014 0.0011 0.0032
Onchocerca volvulus 0.0915839 0.5 0.5
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0296 0.0629 0.0629
Loa Loa (eye worm) blistered cuticle protein 3 0.0915839 0.5 0.5
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0026 0.2404
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0013 0.0008 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.003 0.003
Onchocerca volvulus Peroxidasin homolog 0.1348 0.2937 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Echinococcus granulosus neuropeptide receptor A26 0.1478 0.3222 0.3222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0013 0.0016
Schistosoma mansoni hypothetical protein 0.0119 0.024 0.024
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0054 0.4971
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0062 0.0386
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.003 0.003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0026 0.0026
Loa Loa (eye worm) animal heme peroxidase 0.1348 0.2937 1
Schistosoma mansoni nuclear receptor 0.0011 0.0003 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0019 0.2388
Brugia malayi Animal haem peroxidase family protein 0.1348 0.2937 1
Loa Loa (eye worm) Notch2 0.0296 0.0629 0.2137
Schistosoma mansoni hypothetical protein 0.0348 0.0743 0.0743
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0019 0.1787
Brugia malayi Cathepsin L-like precursor 0.0018 0.0019 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0131 0.0989
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0615 0.1328 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.002 0.0071
Brugia malayi Delta serrate ligand family protein 0.0296 0.0629 0.2141
Brugia malayi hypothetical protein 0.0257 0.0543 0.1848
Entamoeba histolytica hypothetical protein 0.0053 0.0095 1
Schistosoma mansoni hypothetical protein 0.0296 0.0629 0.0629
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Echinococcus granulosus slit 2 protein 0.0296 0.0629 0.0629
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.0108 0.0108
Onchocerca volvulus 0.0018 0.0019 0.0055
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0006 0.002
Brugia malayi ecdysone receptor 0.0011 0.0003 0.0011
Onchocerca volvulus 0.1348 0.2937 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.003 0.0101
Schistosoma mansoni hypothetical protein 0.0014 0.0011 0.0011
Brugia malayi nuclear hormone receptor 0.0023 0.003 0.0101
Plasmodium falciparum glutathione reductase 0.0054 0.0097 0.8991
Brugia malayi Cytochrome P450 family protein 0.0014 0.0011 0.0037
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0014 0.0009 0.0032
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.0006
Loa Loa (eye worm) animal heme peroxidase 0.1348 0.2937 1
Brugia malayi hypothetical protein 0.0019 0.0021 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.0016
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0019 0.2388
Loa Loa (eye worm) ctsf protein 0.0018 0.0019 0.0061
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0053 0.0095 0.064
Brugia malayi Doublecortin family protein 0.0059 0.0108 0.0368
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0013 0.0098
Schistosoma mansoni notch 0.0296 0.0629 0.0629
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0013 0.0033
Echinococcus multilocularis cpg binding protein 0.0034 0.0055 0.0055
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.002 0.1875
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0119 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.003 0.003
Brugia malayi Cadherin domain containing protein 0.0296 0.0629 0.2141
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0054 0.4971
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.002 0.0153
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0026 0.0764
Echinococcus granulosus intermediate filament protein 0.0057 0.0104 0.0104
Schistosoma mansoni laminin gamma-3 chain 0.0296 0.0629 0.0629
Loa Loa (eye worm) DR-78 0.0011 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0059 0.0108 0.0364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0131 0.0989
Echinococcus multilocularis neural cadherin 0.0296 0.0629 0.0629
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0131 0.0989
Echinococcus granulosus peroxidasin 0.0915839 0.5 0.5
Schistosoma mansoni zinc finger protein 0.0011 0.0003 0.0003
Brugia malayi EGF-like domain containing protein 0.0296 0.0629 0.2141
Toxoplasma gondii EGF family domain-containing protein 0.0296 0.0629 1
Brugia malayi hypothetical protein 0.0011 0.0003 0.0011
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0011 0.0032
Echinococcus multilocularis fibropellin Ia 0.0296 0.0629 0.0629
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.003 0.003
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.003 0.0101
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Brugia malayi Phospholipase A2 family protein 0.0089 0.0175 0.0595
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0053 0.0095 0.8801
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.002 0.0153
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0054 0.0097 0.0655
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0019 0.2388
Schistosoma mansoni lipoxygenase 0.0351 0.075 0.075
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0188 0.0391 0.1327
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0054 0.0178
Loa Loa (eye worm) notch protein 0.0296 0.0629 0.2137
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.003 0.009
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0027 0.004 0.013
Loa Loa (eye worm) hypothetical protein 0.1348 0.2937 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.0629 0.2137
Brugia malayi hypothetical protein 0.0029 0.0044 0.0149
Loa Loa (eye worm) hypothetical protein 0.0089 0.0175 0.0591
Schistosoma mansoni cpg binding protein 0.0034 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0915839 0.5 0.5
Loa Loa (eye worm) acetyltransferase 0.0157 0.0325 0.1101
Echinococcus multilocularis survival motor neuron protein 1 0.0257 0.0543 0.0543
Schistosoma mansoni peroxidasin 0.1348 0.2937 0.2937
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0131 0.0989
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.004 0.004
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0006 0.002
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0044 0.4031
Echinococcus granulosus neural cadherin 0.0296 0.0629 0.0629
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0053 0.0095 0.1364
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0119 0.024 0.024
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.002 0.0153
Brugia malayi EGF-like domain containing protein 0.0296 0.0629 0.2141
Plasmodium vivax multidomain scavenger receptor, putative 0.0059 0.0108 1
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0026 0.3213
Brugia malayi Calcitonin receptor-like protein seb-1 0.0375 0.0802 0.2732
Schistosoma mansoni rab6-interacting 0.0059 0.0108 0.0108
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0119 0.024 0.0817
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0104 0.0351
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0019 0.1787
Schistosoma mansoni cell polarity protein 0.0296 0.0629 0.0629
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0019 0.2388
Brugia malayi Peroxidasin 0.1348 0.2937 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.003 0.0096
Mycobacterium tuberculosis Probable dehydrogenase 0.0122 0.0248 0.1801
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0008 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.0293 0.0293
Echinococcus granulosus RUN 0.0059 0.0108 0.0108
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.002 0.1875
Echinococcus multilocularis Polycystic kidney disease protein 0.0059 0.0108 0.0108
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.002 0.0071
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0071 0.6833
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0136 0.0278 0.2029
Onchocerca volvulus Slit protein homolog 0.0296 0.0629 0.2132

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 18 nM Antimalarial activity against Plasmodium falciparum 3D7 infected in human O+ erythrocytes after 72 hrs by [3H]hypoxanthine incorporation assay using DAPI staining ChEMBL. 19699641
EC50 (functional) = 30 nM Antimalarial activity against Plasmodium falciparum Dd2 infected in human O+ erythrocytes after 72 hrs by [3H]hypoxanthine incorporation assay using DAPI staining ChEMBL. 19699641
EC50 (ADMET) = 0.2 uM Cytotoxicity against human RPTEC after 4 days by Alamar blue assay ChEMBL. 19699641
EC50 (ADMET) = 1 uM Cytotoxicity against NHDF after 4 days by Alamar blue assay ChEMBL. 19699641
IC50 (ADMET) Inhibition of human CYP2D6 ChEMBL. 19699641
IC50 (ADMET) Inhibition of human CYP2C19 ChEMBL. 19699641
IC50 (ADMET) Inhibition of human CYP1A2 ChEMBL. 19699641
IC50 (ADMET) Inhibition of human CYP3A4 ChEMBL. 19699641
IC50 (ADMET) Inhibition of human CYP2C9 ChEMBL. 19699641

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 19699641
Homo sapiens ChEMBL23 19699641

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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