Detailed information for compound 1075230

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 474.558 | Formula: C25H30N8O2
  • H donors: 3 H acceptors: 4 LogP: 4.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc(cc1)C(=NNc1nc(nc(n1)N1CCOCC1)Nc1cc(C)ccc1C)C
  • InChi: 1S/C25H30N8O2/c1-16-5-6-17(2)22(15-16)27-23-28-24(30-25(29-23)33-11-13-35-14-12-33)32-31-18(3)20-7-9-21(10-8-20)26-19(4)34/h5-10,15H,11-14H2,1-4H3,(H,26,34)(H2,27,28,29,30,32)
  • InChiKey: TUIUQXCJBQEAEJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Thioredoxin family protein 0.0020856 0.00598903 0.0288184
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00393541 0.0208237 0.124285
Brugia malayi Cathepsin L-like precursor 0.00393541 0.0208237 0.100201
Echinococcus granulosus serotonin transporter 0.0243484 0.184527 0.24566
Onchocerca volvulus 0.00647279 0.0411725 0.223124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00393541 0.0208237 0.124285
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00603061 0.0376264 0.0569027
Loa Loa (eye worm) sema domain-containing protein 0.00283796 0.0120226 0.0617423
Schistosoma mansoni sodium/chloride dependent transporter 0.00446401 0.0250629 0.0379028
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Schistosoma mansoni serine/threonine protein kinase 0.00688265 0.0444594 0.0672363
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00603061 0.0376264 0.0569027
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Echinococcus granulosus carbonic anhydrase II 0.015274 0.111754 0.148778
Brugia malayi neuropeptide F receptor 0.00603061 0.0376264 0.181053
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Echinococcus granulosus Transglutaminase 0.0020856 0.00598903 0.00797314
Schistosoma mansoni myosin xvIII 0.00603061 0.0376264 0.0569027
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.00435542 0.0241921 0.026046
Echinococcus granulosus dro:myosuppressin receptor 0.00603061 0.0376264 0.0500917
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.00435542 0.0241921 0.0183127
Echinococcus granulosus fibroblast growth factor receptor 4 0.00419642 0.022917 0.0305092
Onchocerca volvulus Dual oxidase homolog 0.00203323 0.00556908 0.0301803
Brugia malayi G-protein coupled receptor 0.00603061 0.0376264 0.181053
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00603061 0.0376264 0.193231
Brugia malayi Sema domain containing protein 0.00283796 0.0120226 0.0578513
Schistosoma mansoni tyrosine kinase 0.00742796 0.0488326 0.0738499
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Schistosoma mansoni histamine h1 receptor 0.00603061 0.0376264 0.0569027
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00413321 0.0224101 0.0338909
Echinococcus multilocularis aurora kinase A 0.0121298 0.0865392 0.123137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00393541 0.0208237 0.124285
Mycobacterium ulcerans oxidoreductase 0.0088756 0.060442 0.0547811
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.00435542 0.0241921 0.0183127
Loa Loa (eye worm) hypothetical protein 0.00655185 0.0418066 0.214698
Brugia malayi putative neuropeptide receptor NPR1 0.00603061 0.0376264 0.181053
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.00203323 0.00556908 0.00029599
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.00493892 0.0288715 0.0384364
Schistosoma mansoni cytochrome P450 0.00435542 0.0241921 0.0365858
Schistosoma mansoni tyrosine kinase 0.00474413 0.0273094 0.0413002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Loa Loa (eye worm) plexin A 0.00764483 0.0505718 0.259712
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.00435542 0.0241921 0.026046
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Schistosoma mansoni protein kinase 0.0121298 0.0865392 0.130874
Schistosoma mansoni Neurotrimin precursor (hNT) 0.00450364 0.0253808 0.0383835
Brugia malayi RE15519p 0.00603061 0.0376264 0.181053
Echinococcus granulosus semaphorin 5B 0.00283796 0.0120226 0.0160056
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00603061 0.0376264 0.0569027
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Schistosoma mansoni serine/threonine protein kinase 0.0121298 0.0865392 0.130874
Brugia malayi Immunoglobulin I-set domain containing protein 0.00462472 0.0263517 0.126801
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00603061 0.0376264 0.0569027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0088756 0.060442 0.0650739
Entamoeba histolytica cell division protein kinase 2, putative 0.00688265 0.0444594 0.24032
Echinococcus granulosus cathepsin L cysteine proteinase 0.00393541 0.0208237 0.0277225
Toxoplasma gondii histone lysine-specific demethylase 0.0088756 0.060442 0.602877
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.00742796 0.0488326 0.0650104
Loa Loa (eye worm) cytochrome P450 family protein 0.0147253 0.107354 0.551319
Entamoeba histolytica cysteine proteinase, putative 0.00393541 0.0208237 0.0944448
Plasmodium falciparum cysteine proteinase falcipain 3 0.00393541 0.0208237 0.188879
Echinococcus granulosus neuropeptide receptor 0.00603061 0.0376264 0.0500917
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0088756 0.060442 0.677885
Brugia malayi Cathepsin L-like precursor 0.00263439 0.0103901 0.049996
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Echinococcus multilocularis neuropeptide receptor 0.00603061 0.0376264 0.0535388
Brugia malayi sulfakinin receptor protein 0.00603061 0.0376264 0.181053
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00603061 0.0376264 0.0569027
Plasmodium falciparum carbonic anhydrase 0.00827145 0.055597 0.618083
Echinococcus multilocularis sodium and chloride dependent glycine 0.00413321 0.0224101 0.0318874
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00603061 0.0376264 0.0500917
Trichomonas vaginalis peptide N-glycanase, putative 0.0020856 0.00598903 0.0357451
Echinococcus granulosus sodium and chloride dependent glycine 0.00413321 0.0224101 0.0298343
Echinococcus multilocularis carbonic anhydrase 0.00827145 0.055597 0.0791093
Echinococcus multilocularis g protein coupled receptor 0.00603061 0.0376264 0.0535388
Schistosoma mansoni hypothetical protein 0.00358246 0.0179932 0.0272113
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00603061 0.0376264 0.0535388
Schistosoma mansoni growth hormone secretagogue receptor 0.00603061 0.0376264 0.0569027
Brugia malayi neuropeptide F receptor 0.00603061 0.0376264 0.181053
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00603061 0.0376264 0.0500917
Trypanosoma brucei cdc2-related kinase 1 0.00688265 0.0444594 0.24032
Brugia malayi hypothetical protein 0.0088756 0.060442 0.290839
Loa Loa (eye worm) hypothetical protein 0.00827145 0.055597 0.285519
Echinococcus multilocularis cyclin dependent kinase 0.00688265 0.0444594 0.0632615
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.00435542 0.0241921 0.026046
Trichomonas vaginalis CAMK family protein kinase 0.0222312 0.167548 1
Echinococcus granulosus orexin receptor type 2 0.00603061 0.0376264 0.0500917
Leishmania major carbonic anhydrase-like protein 0.015274 0.111754 0.65555
Brugia malayi hypothetical protein 0.00603061 0.0376264 0.181053
Loa Loa (eye worm) melatonin receptor type 1A 0.00603061 0.0376264 0.193231
Schistosoma mansoni alpha-1 adrenergic receptor 0.00603061 0.0376264 0.0569027
Loa Loa (eye worm) hypothetical protein 0.00462472 0.0263517 0.13533
Loa Loa (eye worm) TK/DDR protein kinase 0.00586338 0.0362853 0.186343
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00393541 0.0208237 0.124285
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.015274 0.111754 0.169007
Echinococcus granulosus cyclin dependent kinase 0.00688265 0.0444594 0.0591884
Brugia malayi ADAM-TS Spacer 1 family protein 0.00383991 0.0200579 0.0965158
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0222312 0.167548 0.860445
Trypanosoma cruzi UDP-galactopyranose mutase 0.0088756 0.060442 0.338961
Loa Loa (eye worm) hypothetical protein 0.0088756 0.060442 0.3104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00603061 0.0376264 0.0569027
Schistosoma mansoni neuropeptide f receptor 76f 0.00603061 0.0376264 0.0569027
Echinococcus granulosus alpha 1A adrenergic receptor 0.00603061 0.0376264 0.0500917
Schistosoma mansoni amine GPCR 0.00603061 0.0376264 0.0569027
Loa Loa (eye worm) hypothetical protein 0.00283796 0.0120226 0.0617423
Echinococcus granulosus g protein coupled receptor 0.00603061 0.0376264 0.0500917
Mycobacterium tuberculosis Possible oxidoreductase 0.0088756 0.060442 0.0650739
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0088756 0.060442 0.0914069
Schistosoma mansoni opsin-like receptor 0.00603061 0.0376264 0.0569027
Loa Loa (eye worm) hypothetical protein 0.0140531 0.101964 0.523636
Schistosoma mansoni neuropeptide receptor 0.00603061 0.0376264 0.0569027
Schistosoma mansoni cathepsin F (C01 family) 0.00393541 0.0208237 0.0314919
Schistosoma mansoni plexin 0.00358246 0.0179932 0.0272113
Brugia malayi hypothetical protein 0.00603061 0.0376264 0.181053
Schistosoma mansoni neuropeptide receptor 0.00603061 0.0376264 0.0569027
Echinococcus granulosus 7TM GPCR rhodopsin 0.00603061 0.0376264 0.0500917
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Echinococcus multilocularis epidermal growth factor receptor 0.0131311 0.0945693 0.134563
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0088756 0.060442 0.677885
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00393541 0.0208237 0.10694
Echinococcus multilocularis neuropeptide Y receptor 0.00603061 0.0376264 0.0535388
Trypanosoma cruzi cruzipain precursor, putative 0.00760189 0.0502274 0.275919
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00393541 0.0208237 0.124285
Brugia malayi Serotonin/octopamine receptor family protein 7 0.00603061 0.0376264 0.181053
Echinococcus granulosus neuropeptide Y receptor 0.00603061 0.0376264 0.0500917
Entamoeba histolytica protein kinase domain containing protein 0.00209985 0.00610335 0.00359337
Brugia malayi Immunoglobulin I-set domain containing protein 0.0256197 0.194723 0.93698
Echinococcus multilocularis cyclin dependent kinase 5 0.00688265 0.0444594 0.0632615
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.00435542 0.0241921 0.026046
Echinococcus multilocularis 0.00435542 0.0241921 0.034423
Loa Loa (eye worm) hypothetical protein 0.00393541 0.0208237 0.10694
Trichomonas vaginalis CMGC family protein kinase 0.00688265 0.0444594 0.265353
Mycobacterium tuberculosis Hypothetical protein 0.0020856 0.00598903 0.00644799
Brugia malayi serine/threonine-protein kinase plk-2 0.0222312 0.167548 0.80622
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00393541 0.0208237 0.124285
Loa Loa (eye worm) hypothetical protein 0.00493892 0.0288715 0.14827
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00760189 0.0502274 0.275919
Echinococcus multilocularis cathepsin L cysteine protease 0.00393541 0.0208237 0.0296302
Brugia malayi GnHR receptor homolog 0.00603061 0.0376264 0.181053
Schistosoma mansoni tyrosine kinase 0.00655253 0.041812 0.0632326
Mycobacterium tuberculosis Long conserved protein 0.0020856 0.00598903 0.00644799
Trypanosoma cruzi cdc2-related kinase 3 0.00688265 0.0444594 0.24032
Toxoplasma gondii hypothetical protein 0.00827145 0.055597 0.52915
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Echinococcus multilocularis serotonin transporter 0.0243484 0.184527 0.262565
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00760189 0.0502274 0.275919
Onchocerca volvulus 0.0088756 0.060442 0.32755
Brugia malayi Cathepsin L-like precursor 0.00393541 0.0208237 0.100201
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.00688265 0.0444594 0.228322
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0088756 0.060442 0.0860033
Loa Loa (eye worm) cysteine protease 0.00393541 0.0208237 0.10694
Schistosoma mansoni serine/threonine protein kinase 0.0103794 0.0725022 0.109646
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00413321 0.0224101 0.115087
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.00419642 0.022917 0.0305092
Onchocerca volvulus 0.00413321 0.0224101 0.121446
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Trichomonas vaginalis CMGC family protein kinase 0.00688265 0.0444594 0.265353
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.00603061 0.0376264 0.0569027
Loa Loa (eye worm) hypothetical protein 0.00827145 0.055597 0.285519
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00603061 0.0376264 0.0535388
Brugia malayi putative neuropeptide receptor 0.00603061 0.0376264 0.181053
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.00435542 0.0241921 0.0183127
Loa Loa (eye worm) hypothetical protein 0.0243484 0.184527 0.947641
Echinococcus granulosus G protein coupled receptor 139 0.00603061 0.0376264 0.0500917
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00603061 0.0376264 0.0569027
Leishmania major cytochrome p450-like protein 0.00435542 0.0241921 0.114971
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.00435542 0.0241921 0.026046
Trichomonas vaginalis CAMK family protein kinase 0.0222312 0.167548 1
Plasmodium vivax vivapain-2 0.00393541 0.0208237 0.188879
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0121298 0.0865392 0.500027
Brugia malayi Melatonin receptor type 1A 0.00603061 0.0376264 0.181053
Echinococcus multilocularis cysteine protease 0.00393541 0.0208237 0.0296302
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00603061 0.0376264 0.0535388
Schistosoma mansoni hypothetical protein 0.00435542 0.0241921 0.0365858
Echinococcus granulosus epidermal growth factor receptor 0.0131311 0.0945693 0.125899
Loa Loa (eye worm) CYP4Cod1 0.00646851 0.0411382 0.211266
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.00827145 0.055597 0.267525
Brugia malayi Cathepsin L-like precursor 0.00393541 0.0208237 0.100201
Echinococcus granulosus allatostatin A receptor 0.00603061 0.0376264 0.0500917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00263439 0.0103901 0.0620128
Brugia malayi Papain family cysteine protease containing protein 0.00393541 0.0208237 0.100201
Loa Loa (eye worm) hypothetical protein 0.00586338 0.0362853 0.186343
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0103794 0.0725022 0.103164
Loa Loa (eye worm) hypothetical protein 0.00283796 0.0120226 0.0617423
Mycobacterium leprae putative cytochrome p450 0.00435542 0.0241921 0.334289
Leishmania major cathepsin L-like protease 0.00393541 0.0208237 0.0941767
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00603061 0.0376264 0.0500917
Brugia malayi Papain family cysteine protease containing protein 0.00202725 0.00552113 0.0265669
Plasmodium vivax hypothetical protein, conserved 0.0088756 0.060442 0.677885
Onchocerca volvulus 0.00413321 0.0224101 0.121446
Echinococcus multilocularis fmrfamide receptor 0.00603061 0.0376264 0.0535388
Entamoeba histolytica cell division protein kinase 2, putative 0.00688265 0.0444594 0.24032
Plasmodium vivax amine transporter, putative 0.00413321 0.0224101 0.208459
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00603061 0.0376264 0.0569027
Brugia malayi SWIRM domain containing protein 0.0088756 0.060442 0.290839
Schistosoma mansoni serine/threonine protein kinase 0.00688265 0.0444594 0.0672363
Loa Loa (eye worm) neuropeptide F receptor 0.00603061 0.0376264 0.193231
Onchocerca volvulus 0.00393541 0.0208237 0.112849
Loa Loa (eye worm) hypothetical protein 0.00450364 0.0253808 0.130343
Echinococcus multilocularis roundabout 2 0.00558109 0.0340214 0.0484093
Mycobacterium ulcerans monoamine oxidase 0.0088756 0.060442 0.0547811
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00413321 0.0224101 0.0338909
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.00435542 0.0241921 0.0183127
Brugia malayi Furin-like cysteine rich region family protein 0.0131311 0.0945693 0.455055
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.00827145 0.055597 0.267525
Brugia malayi Cathepsin L-like precursor 0.00393541 0.0208237 0.100201
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.00435542 0.0241921 0.026046
Schistosoma mansoni hypothetical protein 0.00603061 0.0376264 0.0569027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00603061 0.0376264 0.0569027
Giardia lamblia Aurora kinase 0.0121298 0.0865392 0.49858
Plasmodium falciparum cysteine proteinase falcipain 2b 0.00393541 0.0208237 0.188879
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.00413321 0.0224101 0.0318874
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Echinococcus granulosus g protein coupled receptor 0.00603061 0.0376264 0.0500917
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0088756 0.060442 0.0547811
Onchocerca volvulus 0.0243484 0.184527 1
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00413321 0.0224101 0.107834
Loa Loa (eye worm) hypothetical protein 0.0088756 0.060442 0.3104
Schistosoma mansoni hypothetical protein 0.00283796 0.0120226 0.0181819
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.00435542 0.0241921 0.0183127
Brugia malayi ORL1-like opioid receptor 0.00603061 0.0376264 0.181053
Echinococcus multilocularis rhodopsin orphan GPCR 0.00603061 0.0376264 0.0535388
Loa Loa (eye worm) cytochrome P450 family protein 0.00646851 0.0411382 0.211266
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00603061 0.0376264 0.0569027
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.00139652 0.000462905 0.000616261
Echinococcus granulosus 7tm_1 domain containing protein 0.00603061 0.0376264 0.0500917
Brugia malayi larval opioid receptor 0.00603061 0.0376264 0.181053
Trichomonas vaginalis AGC family protein kinase 0.0121298 0.0865392 0.516503
Entamoeba histolytica protein kinase , putative 0.0121298 0.0865392 0.500027
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.00435542 0.0241921 0.026046
Echinococcus multilocularis cysteine protease 0.00393541 0.0208237 0.0296302
Trypanosoma cruzi cdc2-related kinase 1 0.00688265 0.0444594 0.24032
Echinococcus multilocularis rhodopsin orphan GPCR 0.00603061 0.0376264 0.0535388
Schistosoma mansoni cathepsin F (C01 family) 0.00263439 0.0103901 0.0157131
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.00435542 0.0241921 0.026046
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00413321 0.0224101 0.0298343
Schistosoma mansoni tyrosine kinase 0.00742796 0.0488326 0.0738499
Loa Loa (eye worm) AUR protein kinase 0.0121298 0.0865392 0.444422
Trypanosoma cruzi major cysteine proteinase, putative 0.00439272 0.0244912 0.117079
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00393541 0.0208237 0.0296302
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.00435542 0.0241921 0.026046
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00413321 0.0224101 0.0338909
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00393541 0.0208237 0.124285
Plasmodium vivax serine/threonine protein kinase, putative 0.00454439 0.0257076 0.24916
Trypanosoma cruzi Eukaryotic translation initiation factor 2-alpha kinase 2 0.0042136 0.0230547 0.108214
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Schistosoma mansoni tyrosine kinase 0.00655253 0.041812 0.0632326
Loa Loa (eye worm) carbonic anhydrase 3 0.015274 0.111754 0.573916
Loa Loa (eye worm) hypothetical protein 0.0088756 0.060442 0.3104
Echinococcus multilocularis neuroglian 0.00502473 0.0295597 0.0420606
Onchocerca volvulus 0.00393541 0.0208237 0.112849
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00603061 0.0376264 0.0569027
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Onchocerca volvulus 0.00393541 0.0208237 0.112849
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.00162967 0.00233267 0.00331917
Onchocerca volvulus 0.00393541 0.0208237 0.112849
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Brugia malayi hypothetical protein 0.00603061 0.0376264 0.181053
Echinococcus multilocularis Transglutaminase 0.0020856 0.00598903 0.00852182
Echinococcus multilocularis neuropeptide s receptor 0.00603061 0.0376264 0.0535388
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Echinococcus granulosus cathepsin l1 0.00393541 0.0208237 0.0277225
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.00646851 0.0411382 0.035361
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.00435542 0.0241921 0.0183127
Brugia malayi Stress-activated protein kinase jnk-1 0.0103794 0.0725022 0.348871
Schistosoma mansoni opsin-like receptor 0.00603061 0.0376264 0.0569027
Trichomonas vaginalis AGC family protein kinase 0.0121298 0.0865392 0.516503
Brugia malayi hypothetical protein 0.00603061 0.0376264 0.181053
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00603061 0.0376264 0.193231
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.00435542 0.0241921 0.026046
Brugia malayi Protein kinase domain containing protein 0.00474413 0.0273094 0.131409
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.126033 1 1
Trypanosoma cruzi Eukaryotic translation initiation factor 2-alpha kinase 2 0.00454439 0.0257076 0.124587
Plasmodium falciparum transporter, putative 0.00413321 0.0224101 0.208459
Echinococcus granulosus cathepsin L 0.00202725 0.00552113 0.00735023
Mycobacterium tuberculosis Conserved protein 0.0020856 0.00598903 0.00644799
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00413321 0.0224101 0.0338909
Loa Loa (eye worm) hypothetical protein 0.00413321 0.0224101 0.115087
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00760189 0.0502274 0.275919
Echinococcus multilocularis rhodopsin orphan GPCR 0.00603061 0.0376264 0.0535388
Loa Loa (eye worm) fibroinase 0.00393541 0.0208237 0.10694
Trypanosoma cruzi cdc2-related kinase 1 0.00688265 0.0444594 0.24032
Echinococcus granulosus rhodopsin orphan GPCR 0.00603061 0.0376264 0.0500917
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.00603061 0.0376264 0.181053
Schistosoma mansoni neuropeptide receptor 0.00603061 0.0376264 0.0569027
Echinococcus granulosus neuropeptide receptor A26 0.00603061 0.0376264 0.0500917
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00603061 0.0376264 0.0569027
Schistosoma mansoni hypothetical protein 0.00283796 0.0120226 0.0181819
Giardia lamblia Kinase, CMGC CDK 0.00688265 0.0444594 0.238119
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.00140824 0.000556926 0.0028601
Trypanosoma cruzi cysteine peptidase, putative 0.00760189 0.0502274 0.275919
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0222312 0.167548 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00413321 0.0224101 0.0298343
Leishmania major cathepsin L-like protease 0.00393541 0.0208237 0.0941767
Loa Loa (eye worm) hypothetical protein 0.00413321 0.0224101 0.115087
Chlamydia trachomatis protoporphyrinogen oxidase 0.0088756 0.060442 1
Echinococcus granulosus cytochrome P450 2K1 0.00435542 0.0241921 0.0322067
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00603061 0.0376264 0.0535388
Echinococcus multilocularis cyclin dependent kinase 1 0.00688265 0.0444594 0.0632615
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Onchocerca volvulus 0.00393541 0.0208237 0.112849
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Schistosoma mansoni tyrosine kinase 0.00474413 0.0273094 0.0413002
Loa Loa (eye worm) TK/EGFR protein kinase 0.0131311 0.0945693 0.485661
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.015274 0.111754 0.169007
Loa Loa (eye worm) hypothetical protein 0.00642041 0.0407525 0.209284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Loa Loa (eye worm) hypothetical protein 0.00211309 0.00620954 0.0318891
Schistosoma mansoni biogenic amine receptor 0.00603061 0.0376264 0.0569027
Toxoplasma gondii hypothetical protein 0.00413321 0.0224101 0.0241392
Brugia malayi hypothetical protein 0.00603061 0.0376264 0.181053
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00603061 0.0376264 0.0500917
Mycobacterium tuberculosis Carboxylesterase LipT 0.0117469 0.0834685 0.0898649
Trypanosoma cruzi cytochrome P450, putative 0.00646851 0.0411382 0.219822
Brugia malayi hypothetical protein 0.00603061 0.0376264 0.181053
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.00435542 0.0241921 0.0183127
Brugia malayi hypothetical protein 0.00603061 0.0376264 0.181053
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.00435542 0.0241921 0.026046
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.00139652 0.000462905 0.00065867
Trichomonas vaginalis CAMK family protein kinase 0.0222312 0.167548 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00263439 0.0103901 0.0620128
Echinococcus granulosus cyclin dependent kinase 5 0.00688265 0.0444594 0.0591884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00202725 0.00552113 0.0329525
Brugia malayi G-protein coupled receptor 0.00603061 0.0376264 0.181053
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Trypanosoma cruzi polo-like protein kinase, putative 0.0222312 0.167548 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00603061 0.0376264 0.0569027
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00603061 0.0376264 0.193231
Brugia malayi Sema domain containing protein 0.00283796 0.0120226 0.0578513
Toxoplasma gondii hypothetical protein 0.00413321 0.0224101 0.0241392
Echinococcus multilocularis semaphorin 5B 0.00283796 0.0120226 0.0171071
Echinococcus granulosus twitchin 0.00535553 0.0322125 0.0428842
Loa Loa (eye worm) hypothetical protein 0.00413321 0.0224101 0.115087
Plasmodium vivax hypothetical protein, conserved 0.0088756 0.060442 0.677885
Echinococcus multilocularis protoporphyrinogen oxidase 0.0088756 0.060442 0.0860033
Echinococcus granulosus hypothetical protein 0.0950032 0.75115 1
Echinococcus multilocularis neuropeptides capa receptor 0.00603061 0.0376264 0.0535388
Echinococcus multilocularis G protein coupled receptor 139 0.00603061 0.0376264 0.0535388
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.00413321 0.0224101 0.0318874
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Leishmania major cathepsin L-like protease 0.00393541 0.0208237 0.0941767
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00603061 0.0376264 0.0569027
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Onchocerca volvulus 0.00263439 0.0103901 0.0563068
Trypanosoma cruzi aurora B kinase, putative 0.0121298 0.0865392 0.500027
Brugia malayi hypothetical protein 0.00603061 0.0376264 0.181053
Schistosoma mansoni neuropeptide receptor 0.00603061 0.0376264 0.0569027
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0243484 0.184527 0.887921
Loa Loa (eye worm) hypothetical protein 0.00413321 0.0224101 0.115087
Leishmania major cathepsin L-like protease 0.00393541 0.0208237 0.0941767
Echinococcus granulosus tm gpcr rhodopsin 0.00603061 0.0376264 0.0500917
Loa Loa (eye worm) G-protein coupled receptor 0.00603061 0.0376264 0.193231
Echinococcus granulosus tm gpcr rhodopsin 0.00603061 0.0376264 0.0500917
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Echinococcus multilocularis neuropeptide receptor 0.00603061 0.0376264 0.0535388
Entamoeba histolytica protein kinase domain containing protein 0.0121298 0.0865392 0.500027
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.00435542 0.0241921 0.026046
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.00688265 0.0444594 0.240095
Brugia malayi Cathepsin L-like precursor 0.00393541 0.0208237 0.100201
Echinococcus multilocularis Immunoglobulin 0.00450364 0.0253808 0.0361144
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00603061 0.0376264 0.0569027
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.00688265 0.0444594 0.0591884
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.00413321 0.0224101 0.0298343
Echinococcus granulosus cathepsin l1 0.00263439 0.0103901 0.0138323
Trypanosoma brucei cytochrome P450, putative 0.00646851 0.0411382 0.219822
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00760189 0.0502274 0.275919
Entamoeba histolytica cysteine proteinase, putative 0.00393541 0.0208237 0.0944448
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.00435542 0.0241921 0.0183127
Toxoplasma gondii aurora kinase 0.0121298 0.0865392 1
Brugia malayi plexin A 0.00764483 0.0505718 0.243345
Leishmania major cathepsin L-like protease 0.00760189 0.0502274 0.275704
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.00393541 0.0208237 0.10694
Loa Loa (eye worm) TK protein kinase 0.00471751 0.0270959 0.139151
Echinococcus multilocularis rhodopsin orphan GPCR 0.00603061 0.0376264 0.0535388
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.126033 1 1
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Echinococcus granulosus neuropeptides capa receptor 0.00603061 0.0376264 0.0500917
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.00450364 0.0253808 0.0383835
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.00419642 0.022917 0.0326087
Echinococcus multilocularis basement membrane specific heparan sulfate 0.00450364 0.0253808 0.0361144
Schistosoma mansoni biogenic amine receptor 0.00603061 0.0376264 0.0569027
Schistosoma mansoni hypothetical protein 0.0020856 0.00598903 0.00905725
Loa Loa (eye worm) TYRA-2 protein 0.00603061 0.0376264 0.193231
Brugia malayi Protein kinase domain containing protein 0.00688265 0.0444594 0.213933
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.00630087 0.0397938 0.211524
Brugia malayi ADAMTS-like protease 0.00134172 0.0000234276 0.00011273
Brugia malayi Plexin repeat family protein 0.00642041 0.0407525 0.196095
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00603061 0.0376264 0.0535388
Trypanosoma brucei eukaryotic translation initiation factor 2-alpha kinase 2 0.00454439 0.0257076 0.124587
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.00435542 0.0241921 0.026046
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Loa Loa (eye worm) hypothetical protein 0.00290006 0.0125207 0.0643
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.00603061 0.0376264 0.203907
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00202725 0.00552113 0.00834964
Trichomonas vaginalis CAMK family protein kinase 0.0222312 0.167548 1
Echinococcus granulosus serotonin receptor 0.00603061 0.0376264 0.0500917
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.00435542 0.0241921 0.026046
Brugia malayi Serotonin receptor 0.00603061 0.0376264 0.181053
Echinococcus granulosus semaphorin 1A 0.00283796 0.0120226 0.0160056
Brugia malayi Papain family cysteine protease containing protein 0.00202725 0.00552113 0.0265669
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.00435542 0.0241921 0.0183127
Trypanosoma cruzi polo-like protein kinase, putative 0.0222312 0.167548 1
Echinococcus granulosus carbonic anhydrase 0.00827145 0.055597 0.0740158
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.00435542 0.0241921 0.0183127
Echinococcus granulosus biogenic amine 5HT receptor 0.038392 0.297152 0.395596
Schistosoma mansoni tyrosine kinase 0.00655253 0.041812 0.0632326
Schistosoma mansoni amine GPCR 0.00603061 0.0376264 0.0569027
Onchocerca volvulus 0.00290006 0.0125207 0.0678526
Schistosoma mansoni biogenic amine (5HT) receptor 0.038392 0.297152 0.449385
Schistosoma mansoni hypothetical protein 0.00603061 0.0376264 0.0569027
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.00688265 0.0444594 0.240095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00760189 0.0502274 0.275919
Brugia malayi gonadotropin-releasing hormone receptor 2 0.00603061 0.0376264 0.181053
Entamoeba histolytica cysteine protease, putative 0.00393541 0.0208237 0.0944448
Schistosoma mansoni plexin 0.00642041 0.0407525 0.0616303
Schistosoma mansoni cathepsin F (C01 family) 0.00393541 0.0208237 0.0314919
Loa Loa (eye worm) AUR protein kinase 0.0121298 0.0865392 0.444422
Echinococcus granulosus carbonic anhydrase 0.00827145 0.055597 0.0740158
Echinococcus granulosus insulin growth factor 1 receptor beta 0.00486521 0.0282804 0.0376494
Brugia malayi Fibronectin type III domain containing protein 0.00462472 0.0263517 0.126801
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.00435542 0.0241921 0.0183127
Plasmodium vivax vivapain-2 0.00393541 0.0208237 0.188879
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.00435542 0.0241921 0.0183127
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Schistosoma mansoni kinase 0.083792 0.661241 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.00413321 0.0224101 0.107834
Schistosoma mansoni hypothetical protein 0.00603061 0.0376264 0.0569027
Brugia malayi serine/threonine protein kinase 6 0.0121298 0.0865392 0.416415
Loa Loa (eye worm) hypothetical protein 0.00263439 0.0103901 0.0533586
Echinococcus granulosus neuropeptide s receptor 0.00603061 0.0376264 0.0500917
Echinococcus granulosus cyclin dependent kinase 1 0.00688265 0.0444594 0.0591884
Giardia lamblia Kinase, CMGC CDK 0.00688265 0.0444594 0.238119
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00413321 0.0224101 0.0241392
Schistosoma mansoni carbonic anhydrase 0.00827145 0.055597 0.0840798
Brugia malayi amine oxidase, flavin-containing family protein 0.0088756 0.060442 0.290839
Echinococcus granulosus rhodopsin orphan GPCR 0.00603061 0.0376264 0.0500917
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00393541 0.0208237 0.124285
Echinococcus granulosus discoidin domain receptor 0.00559736 0.0341519 0.0454661
Plasmodium falciparum protoporphyrinogen oxidase 0.0088756 0.060442 0.677885
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Brugia malayi follicle stimulating hormone receptor 0.00603061 0.0376264 0.181053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00393541 0.0208237 0.124285
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Echinococcus multilocularis epidermal growth factor receptor 0.00742796 0.0488326 0.0694842
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00413321 0.0224101 0.0338909
Schistosoma mansoni hypothetical protein 0.00827145 0.055597 0.0840798
Echinococcus granulosus g-protein coupled receptor 0.00603061 0.0376264 0.0500917
Echinococcus multilocularis hypothetical protein 0.00283796 0.0120226 0.0171071
Loa Loa (eye worm) TK/INSR protein kinase 0.00474413 0.0273094 0.140248
Loa Loa (eye worm) hypothetical protein 0.00358246 0.0179932 0.0924043
Mycobacterium leprae Conserved hypothetical protein 0.00435542 0.0241921 0.334289
Trichomonas vaginalis CAMK family protein kinase 0.0222312 0.167548 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.00435542 0.0241921 0.0183127
Brugia malayi G protein-coupled receptor 0.00603061 0.0376264 0.181053
Schistosoma mansoni hypothetical protein 0.00603061 0.0376264 0.0569027
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Echinococcus multilocularis neuropeptides capa receptor 0.00603061 0.0376264 0.0535388
Onchocerca volvulus 0.00642041 0.0407525 0.220848
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00603061 0.0376264 0.0569027
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00603061 0.0376264 0.0535388
Trypanosoma cruzi cytochrome p450-like protein, putative 0.00435542 0.0241921 0.115233
Brugia malayi Tachykinin-like peptides receptor 99D 0.00603061 0.0376264 0.181053
Echinococcus granulosus roundabout 2 0.00558109 0.0340214 0.0452924
Giardia lamblia Kinase, PLK 0.0222312 0.167548 1
Brugia malayi hypothetical protein 0.00413321 0.0224101 0.107834
Brugia malayi cytochrome P450 0.00435542 0.0241921 0.116409
Echinococcus multilocularis conserved hypothetical protein 0.0889726 0.702787 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00603061 0.0376264 0.0569027
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00603061 0.0376264 0.0500917
Loa Loa (eye worm) blistered cuticle protein 3 0.00203323 0.00556908 0.0286001
Echinococcus granulosus aurora kinase A 0.0121298 0.0865392 0.115209
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Echinococcus granulosus c-Jun N-terminal kinases 0.0103794 0.0725022 0.0965215
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00413321 0.0224101 0.0338909
Plasmodium vivax protein kinase Crk2 0.00688265 0.0444594 0.480613
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00760189 0.0502274 0.275919
Echinococcus multilocularis orexin receptor type 2 0.00603061 0.0376264 0.0535388
Echinococcus multilocularis sodium and chloride dependent glycine 0.00413321 0.0224101 0.0318874
Loa Loa (eye worm) hypothetical protein 0.0088756 0.060442 0.3104
Loa Loa (eye worm) hypothetical protein 0.00263439 0.0103901 0.0533586
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.00827145 0.055597 0.285519
Schistosoma mansoni nephrin 0.00514581 0.0305307 0.0461717
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.00827145 0.055597 0.267525
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.00203323 0.00556908 0.00029599
Loa Loa (eye worm) TK/ROR protein kinase 0.00139652 0.000462905 0.00237725
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00413321 0.0224101 0.107834
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Brugia malayi Dopamine receptor protein 1 0.00603061 0.0376264 0.181053
Loa Loa (eye worm) hypothetical protein 0.00546001 0.0330504 0.169731
Loa Loa (eye worm) norepinephrine transporter 0.0243484 0.184527 0.947641
Trichomonas vaginalis AGC family protein kinase 0.0121298 0.0865392 0.516503
Loa Loa (eye worm) G-protein coupled receptor 0.00603061 0.0376264 0.193231
Echinococcus granulosus cathepsin l cysteine peptidase 0.00393541 0.0208237 0.0277225
Schistosoma mansoni amine oxidase 0.0088756 0.060442 0.0914069
Echinococcus granulosus plexin a4 0.00764483 0.0505718 0.0673258
Brugia malayi Dopamine receptor protein 2 0.00603061 0.0376264 0.181053
Schistosoma mansoni tyrosine kinase 0.0131311 0.0945693 0.143018
Echinococcus granulosus lysine specific histone demethylase 1A 0.0088756 0.060442 0.080466
Brugia malayi Cathepsin L-like precursor 0.00263439 0.0103901 0.049996
Echinococcus multilocularis biogenic amine (5HT) receptor 0.038392 0.297152 0.422819
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.00435542 0.0241921 0.0183127
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00603061 0.0376264 0.0500917
Loa Loa (eye worm) solute carrier family 6 member 4 0.0243484 0.184527 0.947641
Trypanosoma cruzi UDP-galactopyranose mutase 0.0088756 0.060442 0.338961
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.00435542 0.0241921 0.115233
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00413321 0.0224101 0.107834
Onchocerca volvulus Cathepsin F homolog 0.00393541 0.0208237 0.112849
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Echinococcus granulosus neuropeptides capa receptor 0.00603061 0.0376264 0.0500917
Brugia malayi Blistered cuticle protein 3 0.00203323 0.00556908 0.0267977
Schistosoma mansoni adenoreceptor 0.00603061 0.0376264 0.0569027
Echinococcus granulosus carbonic anhydrase 0.00827145 0.055597 0.0740158
Schistosoma mansoni biogenic amine receptor 0.00603061 0.0376264 0.0569027
Leishmania major cysteine peptidase A (CPA) 0.00393541 0.0208237 0.0941767
Leishmania major cytochrome p450-like protein 0.00435542 0.0241921 0.114971
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.00203323 0.00556908 0.00029599
Trypanosoma cruzi cytochrome P450, putative 0.00646851 0.0411382 0.219822
Schistosoma mansoni amine GPCR 0.00603061 0.0376264 0.0569027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Echinococcus granulosus fmrfamide receptor 0.00603061 0.0376264 0.0500917
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00603061 0.0376264 0.193231
Onchocerca volvulus Cathepsin L homolog 0.00393541 0.0208237 0.112849
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00603061 0.0376264 0.0535388
Echinococcus multilocularis G-protein coupled receptor, putative 0.00603061 0.0376264 0.0535388
Schistosoma mansoni carbonic anhydrase-related 0.00827145 0.055597 0.0840798
Echinococcus granulosus somatostatin receptor 0.00603061 0.0376264 0.0500917
Echinococcus multilocularis sex peptide receptor 0.00603061 0.0376264 0.0535388
Echinococcus multilocularis fmrfamide receptor 0.00603061 0.0376264 0.0535388
Loa Loa (eye worm) ctsf protein 0.00393541 0.0208237 0.10694
Loa Loa (eye worm) hypothetical protein 0.0088756 0.060442 0.3104
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Entamoeba histolytica serine/threonine protein kinase, putative 0.0222312 0.167548 1
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.00435542 0.0241921 0.026046
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0121298 0.0865392 0.500027
Brugia malayi serine/threonine kinase 12 0.0121298 0.0865392 0.416415
Onchocerca volvulus Neuropeptide F receptor homolog 0.00603061 0.0376264 0.203907
Plasmodium falciparum cysteine proteinase falcipain 2a 0.00393541 0.0208237 0.188879
Brugia malayi Cytochrome P450 family protein 0.0147253 0.107354 0.516575
Brugia malayi Protein kinase domain containing protein 0.00647279 0.0411725 0.198117
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.00603061 0.0376264 0.181053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00760189 0.0502274 0.275919
Loa Loa (eye worm) serotonin transporter b 0.0243484 0.184527 0.947641
Echinococcus granulosus defective proboscis extension response 0.00450364 0.0253808 0.0337892
Loa Loa (eye worm) hypothetical protein 0.00283796 0.0120226 0.0617423
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0088756 0.060442 0.677885
Echinococcus multilocularis neuropeptide Y receptor 0.00603061 0.0376264 0.0535388
Schistosoma mansoni semaphorin 5-related 0.00290006 0.0125207 0.0189351
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.00435542 0.0241921 0.0183127
Brugia malayi Cytochrome P450 family protein 0.00646851 0.0411382 0.197951
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Brugia malayi Serotonin receptor 0.0272528 0.20782 1
Loa Loa (eye worm) cytochrome P450 family protein 0.00646851 0.0411382 0.211266
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0121298 0.0865392 0.123137
Loa Loa (eye worm) hypothetical protein 0.00283796 0.0120226 0.0617423
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00603061 0.0376264 0.0535388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00760189 0.0502274 0.275919
Echinococcus granulosus rhodopsin orphan GPCR 0.00603061 0.0376264 0.0500917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.00435542 0.0241921 0.026046
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00413321 0.0224101 0.0338909
Schistosoma mansoni amine oxidase 0.0088756 0.060442 0.0914069
Echinococcus granulosus insulin receptor 0.00474413 0.0273094 0.0363568
Loa Loa (eye worm) hypothetical protein 0.00450607 0.0254003 0.130443
Schistosoma mansoni amine GPCR 0.00603061 0.0376264 0.0569027
Echinococcus multilocularis carbonic anhydrase 0.00827145 0.055597 0.0791093
Plasmodium vivax hypothetical protein, conserved 0.00413321 0.0224101 0.208459
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00413321 0.0224101 0.0241392
Brugia malayi hypothetical protein 0.00283796 0.0120226 0.0578513
Echinococcus granulosus lysine specific histone demethylase 1A 0.0088756 0.060442 0.080466
Onchocerca volvulus 0.0198053 0.148094 0.802558
Schistosoma mansoni tyrosine kinase 0.00419642 0.022917 0.0346575
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0121298 0.0865392 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.00603061 0.0376264 0.0535388
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.00688265 0.0444594 0.228322
Echinococcus granulosus cathepsin L cysteine protease 0.00202725 0.00552113 0.00735023
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.00435542 0.0241921 0.0183127
Leishmania major protein kinase, putative 0.0121298 0.0865392 0.49988
Trypanosoma brucei polo-like protein kinase 0.0222312 0.167548 1
Echinococcus granulosus neuropeptide FF receptor 2 0.00603061 0.0376264 0.0500917
Entamoeba histolytica tyrosin kinase, putative 0.00209985 0.00610335 0.00359337
Echinococcus multilocularis g protein coupled receptor 0.00603061 0.0376264 0.0535388
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0088756 0.060442 0.0914069
Schistosoma mansoni vesicular amine transporter 0.00450364 0.0253808 0.0383835
Loa Loa (eye worm) hypothetical protein 0.0243484 0.184527 0.947641
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Leishmania major lanosterol 14-alpha-demethylase, putative 0.00435542 0.0241921 0.114971
Schistosoma mansoni tyrosine kinase 0.0018318 0.00395369 0.00597919
Onchocerca volvulus Cathepsin L homolog 0.00393541 0.0208237 0.112849
Treponema pallidum sodium- and chloride- dependent transporter 0.0243484 0.184527 0.5
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.00435542 0.0241921 0.026046
Echinococcus multilocularis g-protein coupled receptor 0.00603061 0.0376264 0.0535388
Echinococcus multilocularis 0.0088756 0.060442 0.0860033
Trichomonas vaginalis CAMK family protein kinase 0.0222312 0.167548 1
Trypanosoma brucei carbonic anhydrase-like protein 0.015274 0.111754 0.655652
Loa Loa (eye worm) hypothetical protein 0.0243484 0.184527 0.947641
Loa Loa (eye worm) hypothetical protein 0.00827145 0.055597 0.285519
Trichomonas vaginalis AGC family protein kinase 0.0121298 0.0865392 0.516503
Leishmania major cathepsin L-like protease 0.00760189 0.0502274 0.275704
Brugia malayi Cytochrome P450 family protein 0.00646851 0.0411382 0.197951
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00603061 0.0376264 0.0535388
Leishmania major UDP-galactopyranose mutase 0.0088756 0.060442 0.338765
Entamoeba histolytica protein kinase, putative 0.0121298 0.0865392 0.500027
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00603061 0.0376264 0.0535388
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0088756 0.060442 1
Schistosoma mansoni amine GPCR 0.00603061 0.0376264 0.0569027
Echinococcus multilocularis rhodopsin orphan GPCR 0.00603061 0.0376264 0.0535388
Brugia malayi G protein-coupled receptor F59B2.13 0.00603061 0.0376264 0.181053
Loa Loa (eye worm) AUR protein kinase 0.0121298 0.0865392 0.444422
Brugia malayi cell division control protein 2 homolog 0.00688265 0.0444594 0.213933
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00413321 0.0224101 0.0241392
Echinococcus granulosus rhodopsin orphan GPCR 0.00603061 0.0376264 0.0500917
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.00827145 0.055597 0.267525
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.00435542 0.0241921 0.026046
Loa Loa (eye worm) hypothetical protein 0.00559736 0.0341519 0.175387
Loa Loa (eye worm) hypothetical protein 0.00413321 0.0224101 0.115087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Trichomonas vaginalis STE family protein kinase 0.00454439 0.0257076 0.153434
Echinococcus granulosus neuropeptide receptor 0.00603061 0.0376264 0.0500917
Loa Loa (eye worm) hypothetical protein 0.0088756 0.060442 0.3104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00760189 0.0502274 0.275919
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.00827145 0.055597 0.267525
Schistosoma mansoni sodium/chloride dependent transporter 0.00413321 0.0224101 0.0338909
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0103794 0.0725022 0.372335
Echinococcus granulosus g protein coupled receptor 0.00603061 0.0376264 0.0500917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00202725 0.00552113 0.0329525
Loa Loa (eye worm) cytochrome P450 0.00435542 0.0241921 0.124238
Leishmania major protein kinase, putative,eukaryotic translation initiation factor 2-alpha kinase precursor, putative 0.00454439 0.0257076 0.124328
Plasmodium falciparum protein kinase 5 0.00688265 0.0444594 0.480613
Brugia malayi hypothetical protein 0.00283796 0.0120226 0.0578513
Schistosoma mansoni sodium-dependent amino acid transporter 0.00413321 0.0224101 0.0338909
Onchocerca volvulus 0.0020856 0.00598903 0.032456
Onchocerca volvulus Tyrosine kinase homolog 0.0212019 0.159294 0.863252
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.00435542 0.0241921 0.0183127
Brugia malayi Putative carbonic anhydrase 5 precursor 0.015274 0.111754 0.537748
Trichomonas vaginalis CMGC family protein kinase 0.00688265 0.0444594 0.265353
Onchocerca volvulus 0.00393541 0.0208237 0.112849
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00603061 0.0376264 0.193231
Loa Loa (eye worm) hypothetical protein 0.00413321 0.0224101 0.115087
Echinococcus granulosus tm gpcr rhodopsin 0.00603061 0.0376264 0.0500917
Echinococcus multilocularis serotonin receptor 0.00603061 0.0376264 0.0535388
Brugia malayi cathepsin L-like precursor 0.00263439 0.0103901 0.049996
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0121298 0.0865392 0.500027
Loa Loa (eye worm) hypothetical protein 0.00462472 0.0263517 0.13533
Trypanosoma cruzi cysteine peptidase, putative 0.00393541 0.0208237 0.0944448
Brugia malayi hypothetical protein 0.00603061 0.0376264 0.181053
Entamoeba histolytica protein kinase, putative 0.0121298 0.0865392 0.500027
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.015274 0.111754 0.573916
Trypanosoma brucei aurora B kinase 0.0121298 0.0865392 0.500027
Echinococcus granulosus Immunoglobulin 0.00450364 0.0253808 0.0337892
Leishmania major cathepsin L-like protease 0.00393541 0.0208237 0.0941767
Echinococcus multilocularis carbonic anhydrase 0.00827145 0.055597 0.0791093
Mycobacterium tuberculosis Conserved hypothetical protein 0.0020856 0.00598903 0.00644799
Leishmania major cytochrome p450-like protein 0.00646851 0.0411382 0.219591
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00393541 0.0208237 0.124285
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.00435542 0.0241921 0.115233
Echinococcus multilocularis cathepsin L 0.00202725 0.00552113 0.00785604
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.00162967 0.00233267 0.00352772
Trypanosoma cruzi cysteine peptidase, putative 0.00760189 0.0502274 0.275919
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Echinococcus granulosus epidermal growth factor receptor 0.00742796 0.0488326 0.0650104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00393541 0.0208237 0.0296302
Mycobacterium ulcerans carboxylesterase, LipT 0.0117469 0.0834685 0.0779463
Brugia malayi AKH receptor 0.00603061 0.0376264 0.181053
Echinococcus granulosus neuropeptide Y receptor 0.00603061 0.0376264 0.0500917
Trypanosoma cruzi Eukaryotic translation initiation factor 2-alpha kinase 2 0.00454439 0.0257076 0.124587
Echinococcus granulosus sex peptide receptor 0.00603061 0.0376264 0.0500917
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Onchocerca volvulus 0.00393541 0.0208237 0.112849
Schistosoma mansoni opsin-like receptor 0.00603061 0.0376264 0.0569027
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00413321 0.0224101 0.115087
Echinococcus multilocularis somatostatin receptor 0.00603061 0.0376264 0.0535388
Toxoplasma gondii cytochrome p450 superfamily protein 0.00435542 0.0241921 0.0512561
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0121298 0.0865392 0.115209
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Echinococcus multilocularis carbonic anhydrase II 0.015274 0.111754 0.159016
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.00435542 0.0241921 0.115233
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00603061 0.0376264 0.0569027
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00603061 0.0376264 0.0535388
Brugia malayi angiogenesis inhibito 0.00134172 0.0000234276 0.00011273
Echinococcus multilocularis dro:myosuppressin receptor 0.00603061 0.0376264 0.0535388
Schistosoma mansoni neuropeptide F-like receptor 0.00603061 0.0376264 0.0569027
Brugia malayi Cathepsin L-like precursor 0.00393541 0.0208237 0.100201
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00393541 0.0208237 0.124285
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00202725 0.00552113 0.00834964
Echinococcus multilocularis fibroblast growth factor receptor 4 0.00419642 0.022917 0.0326087
Mycobacterium ulcerans dehydrogenase 0.0088756 0.060442 0.0547811
Schistosoma mansoni cell adhesion molecule 0.00506 0.0298425 0.0451311
Loa Loa (eye worm) hypothetical protein 0.00462472 0.0263517 0.13533
Loa Loa (eye worm) hypothetical protein 0.00413321 0.0224101 0.115087
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.015274 0.111754 0.655652
Trypanosoma brucei cdc2-related kinase 3 0.00688265 0.0444594 0.24032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Brugia malayi Immunoglobulin I-set domain containing protein 0.00471751 0.0270959 0.130382
Schistosoma mansoni serine/threonine protein kinase 0.0222312 0.167548 0.253385
Loa Loa (eye worm) hypothetical protein 0.00450364 0.0253808 0.130343
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Echinococcus granulosus rhodopsin orphan GPCR 0.00603061 0.0376264 0.0500917
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.00688265 0.0444594 0.228322
Echinococcus granulosus tachykinin peptides receptor 99D 0.00603061 0.0376264 0.0500917
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0222312 0.167548 0.238405
Echinococcus multilocularis serotonin receptor 0.00603061 0.0376264 0.0535388
Echinococcus granulosus a disintegrin and metalloproteinase with 0.00162967 0.00233267 0.00310547
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.00486521 0.0282804 0.0402403
Trichomonas vaginalis CAMK family protein kinase 0.0222312 0.167548 1
Schistosoma mansoni neuropeptide F-like receptor 0.00603061 0.0376264 0.0569027
Loa Loa (eye worm) sema domain-containing protein 0.00283796 0.0120226 0.0617423
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.015274 0.111754 0.655652
Mycobacterium tuberculosis Conserved hypothetical protein 0.0020856 0.00598903 0.00644799
Entamoeba histolytica cysteine proteinase, putative 0.00263439 0.0103901 0.0300506
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00760189 0.0502274 0.275919
Schistosoma mansoni carbonic anhydrase-related 0.00827145 0.055597 0.0840798
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.00435542 0.0241921 0.026046
Brugia malayi Dopamine receptor 0.00603061 0.0376264 0.181053
Echinococcus multilocularis rhodopsin orphan GPCR 0.00603061 0.0376264 0.0535388
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Echinococcus granulosus biogenic amine 5HT receptor 0.00603061 0.0376264 0.0500917
Plasmodium falciparum amino acid transporter, putative 0.00413321 0.0224101 0.208459
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.00435542 0.0241921 0.0183127
Brugia malayi hypothetical protein 0.00462472 0.0263517 0.126801
Echinococcus multilocularis neuropeptide receptor A26 0.00603061 0.0376264 0.0535388
Plasmodium falciparum serine/threonine protein kinase, putative 0.0121298 0.0865392 1
Echinococcus multilocularis g protein coupled receptor 0.00603061 0.0376264 0.0535388
Echinococcus multilocularis plexin a4 0.00764483 0.0505718 0.0719589
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0618917 0.485609 0.646487
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0088756 0.060442 0.602877
Echinococcus multilocularis 0.00381503 0.0198583 0.0282565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00393541 0.0208237 0.124285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00760189 0.0502274 0.275919
Brugia malayi hypothetical protein 0.00603061 0.0376264 0.181053
Echinococcus multilocularis insulin receptor 0.00474413 0.0273094 0.0388587
Echinococcus multilocularis allatostatin A receptor 0.00603061 0.0376264 0.0535388
Leishmania major cathepsin L-like protease 0.00760189 0.0502274 0.275704
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00603061 0.0376264 0.0569027
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00202725 0.00552113 0.00834964
Echinococcus multilocularis cyclin dependent kinase 1 0.00688265 0.0444594 0.0632615
Echinococcus granulosus rhodopsin orphan GPCR 0.00603061 0.0376264 0.0500917
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00603061 0.0376264 0.0535388
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00413321 0.0224101 0.0338909
Loa Loa (eye worm) hypothetical protein 0.00383991 0.0200579 0.103007
Schistosoma mansoni biogenic amine (5HT) receptor 0.00603061 0.0376264 0.0569027
Echinococcus granulosus rhodopsin orphan GPCR 0.00603061 0.0376264 0.0500917
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00603061 0.0376264 0.0569027
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.00435542 0.0241921 0.0183127
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00603061 0.0376264 0.0535388
Schistosoma mansoni sodium/chloride dependent transporter 0.0243484 0.184527 0.279062
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0243484 0.184527 0.279062
Onchocerca volvulus 0.00603061 0.0376264 0.203907
Onchocerca volvulus Serine\/threonine kinase homolog 0.0222312 0.167548 0.907986
Echinococcus granulosus cysteine protease 0.00202725 0.00552113 0.00735023
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0618917 0.485609 0.690976
Echinococcus multilocularis rhodopsin orphan GPCR 0.00603061 0.0376264 0.0535388
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.117158 0.928821 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0256197 0.194723 1
Loa Loa (eye worm) neuropeptide F receptor 0.00603061 0.0376264 0.193231
Echinococcus granulosus neuroglian 0.00502473 0.0295597 0.0393525
Onchocerca volvulus 0.00413321 0.0224101 0.121446
Trypanosoma cruzi cdc2-related kinase 3 0.00688265 0.0444594 0.24032
Schistosoma mansoni carbonic anhydrase-related 0.00827145 0.055597 0.0840798
Trypanosoma cruzi cysteine peptidase, putative 0.00760189 0.0502274 0.275919
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.00413321 0.0224101 0.0318874
Loa Loa (eye worm) hypothetical protein 0.00283796 0.0120226 0.0617423
Echinococcus granulosus sodium and chloride dependent glycine 0.00413321 0.0224101 0.0298343
Echinococcus multilocularis cathepsin L cysteine protease 0.00393541 0.0208237 0.0296302
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.00435542 0.0241921 0.0183127
Echinococcus granulosus peptide allatostatin:somatostatin 0.00603061 0.0376264 0.0500917
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00603061 0.0376264 0.0569027
Loa Loa (eye worm) hypothetical protein 0.00263439 0.0103901 0.0533586
Brugia malayi Cytochrome P450 family protein 0.00435542 0.0241921 0.116409
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.00688265 0.0444594 0.359667
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0222312 0.167548 0.223056
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.00435542 0.0241921 0.026046
Trichomonas vaginalis AGC family protein kinase 0.00454439 0.0257076 0.153434
Echinococcus multilocularis rhodopsin orphan GPCR 0.00603061 0.0376264 0.0535388
Brugia malayi hypothetical protein 0.0140531 0.101964 0.490636
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0088756 0.060442 0.677885
Loa Loa (eye worm) hypothetical protein 0.00603061 0.0376264 0.193231
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.00603061 0.0376264 0.181053
Brugia malayi Cathepsin L-like cysteine proteinase 0.00263439 0.0103901 0.049996
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.00413321 0.0224101 0.0298343
Echinococcus multilocularis Immunoglobulin 0.00450364 0.0253808 0.0361144
Loa Loa (eye worm) hypothetical protein 0.00546001 0.0330504 0.169731
Brugia malayi serine/threonine-protein kinase 6 0.0121298 0.0865392 0.416415
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.015274 0.111754 0.537748

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. ChEMBL. 22096101
CC50 > 10 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
EC50 (functional) > 1.25 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) = 2.055 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 18579783

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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