Detailed information for compound 1076023

Basic information

Technical information
  • TDR Targets ID: 1076023
  • Name: 5-[(3,4-dimethoxyphenyl)methylidene]-2-pyrrol idin-1-yl-1,3-thiazol-4-one
  • MW: 318.391 | Formula: C16H18N2O3S
  • H donors: 0 H acceptors: 1 LogP: 2.89 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)/C=C\1/SC(=NC1=O)N1CCCC1
  • InChi: 1S/C16H18N2O3S/c1-20-12-6-5-11(9-13(12)21-2)10-14-15(19)17-16(22-14)18-7-3-4-8-18/h5-6,9-10H,3-4,7-8H2,1-2H3/b14-10+
  • InChiKey: OYLRLTLKAKMCHY-GXDHUFHOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5E)-5-[(3,4-dimethoxyphenyl)methylidene]-2-pyrrolidin-1-yl-1,3-thiazol-4-one
  • 5-[(3,4-dimethoxyphenyl)methylene]-2-pyrrolidin-1-yl-thiazol-4-one
  • (5E)-5-[(3,4-dimethoxyphenyl)methylene]-2-pyrrolidin-1-yl-thiazol-4-one
  • 5-[(3,4-dimethoxyphenyl)methylene]-2-1-pyrrolidinyl-4-thiazolone
  • (5E)-5-[(3,4-dimethoxyphenyl)methylene]-2-1-pyrrolidinyl-4-thiazolone
  • 5-(3,4-dimethoxybenzylidene)-2-pyrrolidin-1-yl-thiazol-4-one
  • (5E)-5-(3,4-dimethoxybenzylidene)-2-pyrrolidin-1-yl-thiazol-4-one
  • ZINC00083850
  • CBMicro_038387

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium falciparum enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium yoelii enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium vivax enoyl-acyl carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase Get druggable targets OG5_130466 All targets in OG5_130466
Neospora caninum enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium berghei enoyl-acyl carrier reductase Get druggable targets OG5_130466 All targets in OG5_130466
Chlamydia trachomatis enoyl-acyl-carrier protein reductase Get druggable targets OG5_130466 All targets in OG5_130466
Toxoplasma gondii enoyl-acyl carrier reductase ENR Get druggable targets OG5_130466 All targets in OG5_130466
Plasmodium knowlesi enoyl-acyl carrier reductase, putative Get druggable targets OG5_130466 All targets in OG5_130466
Trichomonas vaginalis hypothetical protein Get druggable targets OG5_130466 All targets in OG5_130466
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei heat shock protein, putative 0.0026 0.0104 0.035
Echinococcus granulosus heat shock protein 90 0.0026 0.0104 0.0246
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0123 0.0441
Giardia lamblia Pyruvate kinase 0.0034 0.0151 0.572
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0238 0.1719
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0032 0.0114
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0026 0.0104 0.035
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0051 0.025 0.09
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0032 0.0196
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.025 0.0582
Schistosoma mansoni pyruvate kinase 0.0034 0.0151 0.0346
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0104 0.035
Echinococcus granulosus tumor protein p63 0.0346 0.2024 0.483
Trichomonas vaginalis endoplasmin, putative 0.0026 0.0104 0.0758
Mycobacterium tuberculosis Possible oxidoreductase 0.0015 0.0037 0.0135
Brugia malayi topoisomerase 0.001 0.0007 0.0024
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0109 0.0393
Onchocerca volvulus 0.0014 0.0032 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0008 0.003
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0037 0.0237
Trypanosoma brucei heat shock protein, putative 0.0026 0.0104 0.035
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0015 0.0037 0.0237
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0055 0.028
Plasmodium falciparum DNA gyrase subunit B 0.0026 0.0104 0.0758
Giardia lamblia Pyruvate kinase 0.0018 0.0051 0.177
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0237 0.137 0.493
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0008
Trypanosoma brucei heat shock protein, putative 0.0026 0.0104 0.035
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0238 0.424
Loa Loa (eye worm) heat shock protein 90 0.0026 0.0104 0.0373
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0032 0.009
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0051 0.0349
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0032 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0032 0.0196
Plasmodium falciparum enoyl-acyl carrier reductase 0.0223 0.1287 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0051 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0259 0.1974
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0259 0.0912
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0032 0.0196
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0151 0.0544
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0167 0.0398
Loa Loa (eye worm) hypothetical protein 0.0036 0.0164 0.059
Echinococcus granulosus pyruvate kinase 0.0034 0.0151 0.0359
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0008 0.0009
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0026 0.0104 0.0758
Schistosoma mansoni nuclear hormone receptor 0.001 0.0008 0.0004
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0055 0.028
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0037 0.0237
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0018
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0032 0.0094
Schistosoma mansoni hypothetical protein 0.0419 0.2461 0.5868
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0032 0.0196
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0055 0.038
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0004
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0026 0.0104 0.0758
Brugia malayi hypothetical protein 0.001 0.0007 0.0024
Brugia malayi Cytochrome P450 family protein 0.0057 0.029 0.1043
Echinococcus granulosus heat shock protein 0.0026 0.0104 0.0246
Brugia malayi hypothetical protein 0.0242 0.14 0.5037
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0055 0.028
Onchocerca volvulus 0.001 0.0008 0.0009
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0015 0.0037 0.0086
Loa Loa (eye worm) endoplasmin 0.0026 0.0104 0.0373
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0007 0.0000026917
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0051 0.0349
Echinococcus granulosus expressed conserved protein 0.0095 0.0515 0.1227
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0008 0.0008
Mycobacterium ulcerans DNA gyrase subunit B 0.0026 0.0104 0.0758
Loa Loa (eye worm) hypothetical protein 0.0153 0.0865 0.3111
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0259 0.0829
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0032 0.0114
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0026 0.0104 1
Onchocerca volvulus 0.0015 0.0037 0.0168
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0008 0.0004
Brugia malayi cytochrome P450 0.0018 0.0055 0.0199
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0032 0.0114
Mycobacterium ulcerans two component regulator - sensor kinase 0.0026 0.0104 0.0758
Trichomonas vaginalis receptor histidine kinase, putative 0.0026 0.0104 0.0758
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0104 0.035
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0032 0.0196
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0007 0.0024
Giardia lamblia Pms1-like protein 0.0026 0.0104 0.3841
Brugia malayi hypothetical protein 0.031 0.1804 0.6492
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0026 0.0104 0.0758
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0008 0.0018
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0055 0.028
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0104 0.035
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0104 0.035
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0008 0.003
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0104 0.035
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0055 0.028
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0104 0.0758
Mycobacterium tuberculosis Possible oxidoreductase 0.0015 0.0037 0.0135
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0055 0.0086
Leishmania major pteridine reductase 1 0.0015 0.0037 0.0019
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0151 0.0544
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0037 0.0135
Schistosoma mansoni hypothetical protein 0.0042 0.0197 0.0454
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0008 0.003
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0238 0.075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0008 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0008 0.003
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0055 0.028
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0259 0.0829
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0104 0.0757
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0032 0.0094
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0026 0.0104 1
Echinococcus granulosus pyruvate kinase 0.0018 0.0051 0.0121
Loa Loa (eye worm) hypothetical protein 0.0049 0.0238 0.0855
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0104 0.0757
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0037 0.0237
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.003
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0259 0.1974
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0008 0.0004
Toxoplasma gondii heat shock protein HSP90 0.0026 0.0104 0.0758
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0037 0.0135
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0026 0.0104 0.035
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0015 0.0037 0.0135
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0008
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0026 0.0104 0.0758
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0223 0.1287 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0164 0.059
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0206 0.049
Echinococcus granulosus FTZ F1 alpha 0.001 0.0008 0.0018
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Schistosoma mansoni hypothetical protein 0.0042 0.0197 0.0454
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0015 0.0037 0.0237
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0238 0.1804
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0055 0.038
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0008 0.0004
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0015 0.0037 0.0237
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0032 0.0196
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0104 0.0758
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0109 0.037
Plasmodium vivax heat shock protein 86, putative 0.0026 0.0104 0.0758
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0032 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0008 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0032 0.0094
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0223 0.1287 1
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0206 0.049
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0281 0.214
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0151 0.0521
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0238 0.0855
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0238 0.1719
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Brugia malayi MAP kinase sur-1 0.0052 0.0259 0.0933
Trypanosoma brucei heat shock protein 90, putative 0.0026 0.0104 0.035
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0104 0.035
Trypanosoma cruzi Heat shock protein 83, putative 0.0026 0.0104 0.035
Trichomonas vaginalis sensor histidine kinase, putative 0.0026 0.0104 0.0758
Echinococcus multilocularis 0.0018 0.0055 0.0055
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0007 0.0000063263
Brugia malayi Endoplasmin precursor 0.0026 0.0104 0.0373
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0026 0.0104 0.0758
Loa Loa (eye worm) oxidoreductase 0.0014 0.0032 0.0114
Trypanosoma brucei heat shock protein, putative 0.0026 0.0104 0.035
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0015 0.0037 0.0556
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0167 0.0384
Plasmodium vivax DNA topoisomerase II, putative 0.0026 0.0104 0.0758
Echinococcus multilocularis expressed conserved protein 0.0095 0.0515 0.0514
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0055 0.028
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0004
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0026 0.0104 0.0103
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0259 0.0912
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0015 0.0037 0.0236
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0037 0.0237
Schistosoma mansoni pyruvate kinase 0.0018 0.0051 0.0107
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Brugia malayi Probable DNA topoisomerase II 0.0026 0.0104 0.0373
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0032 0.0114
Brugia malayi CXXC zinc finger family protein 0.0029 0.0123 0.0441
Echinococcus multilocularis nibrin 0.001 0.0007 0.0006
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0032 0.009
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0026 0.0104 0.0662
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0238 0.075
Plasmodium vivax DNA gyrase subunit B, putative 0.0026 0.0104 0.0758
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0037 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0206 0.1556
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0206 0.0205
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0238 0.0855
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0032 0.0094
Onchocerca volvulus 0.0049 0.0243 0.1313
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0238 0.1804
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0109 0.0393
Echinococcus multilocularis microtubule associated protein 2 0.0707 0.4189 0.4189
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0026 0.0104 0.0758
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0104 0.035
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0206 0.0741
Loa Loa (eye worm) hypothetical protein 0.031 0.1804 0.6492
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0026 0.0104 0.0662
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0032 0.0196
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0104 0.054
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0055 0.028
Schistosoma mansoni pyruvate dehydrogenase 0.0446 0.2622 0.6253
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0037 0.0237
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0032 0.0196
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0037 0.0237
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0223 0.1287 1
Schistosoma mansoni coup transcription factor 0.001 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0153 0.0865 0.3111
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0151 0.1129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0008 0.003
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0259 0.0912
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0191 0.1094 0.8494
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0238 0.075
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0032 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.003
Leishmania major cytochrome p450-like protein 0.0018 0.0055 0.0086
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0032 0.0196
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0015 0.0037 0.0135
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0032 0.0114
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0037 0.0237
Brugia malayi CHE-14 protein 0.0043 0.0206 0.0741
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0032 0.009
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.029 0.1043
Echinococcus granulosus microtubule associated protein 2 0.0707 0.4189 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0104 0.035
Schistosoma mansoni heat shock protein 0.0026 0.0104 0.0232
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Toxoplasma gondii heat shock protein 90, putative 0.0026 0.0104 0.0758
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0032 0.0094
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0008 0.003
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0032 0.0074
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0037 0.0237
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0472 0.278 0.6634
Leishmania major pyruvate kinase 0.0034 0.0151 0.0435
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.0032 0.046
Loa Loa (eye worm) retinol dehydrogenase 12 0.0015 0.0037 0.0133
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0259 0.0618
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0055 0.038
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0015 0.0037 0.0019
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0032 0.0196
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0238 0.1804
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Leishmania major cytochrome p450-like protein 0.0018 0.0055 0.0086
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0026 0.0104 0.0662
Schistosoma mansoni cpg binding protein 0.0031 0.0133 0.0302
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.0811 0.0811
Echinococcus multilocularis protein patched 0.0043 0.0206 0.0205
Leishmania major DNA topoisomerase ii 0.0026 0.0104 0.0262
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0015 0.0037 0.0036
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0037 0.0237
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0055 0.028
Mycobacterium ulcerans hypothetical protein 0.0049 0.0238 0.1804
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0053 0.0264 0.0951
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0037 0.0237
Plasmodium falciparum DNA topoisomerase 2 0.0026 0.0104 0.0758
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0032 0.0196
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0165 0.0937 0.7263
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0055 0.038
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0151 0.1037
Loa Loa (eye worm) hypothetical protein 0.0024 0.0089 0.0321
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0026 0.0104 0.0662
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0104 0.0758
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0164 0.1229
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0055 0.038
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0104 0.3841
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0008 0.0004
Trypanosoma brucei heat shock protein, putative 0.0026 0.0104 0.035
Echinococcus multilocularis cpg binding protein 0.0031 0.0133 0.0132
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0238 0.1804
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0055 0.028
Plasmodium falciparum heat shock protein 90 0.0026 0.0104 0.0758
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0037 0.0237
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0373
Schistosoma mansoni hypothetical protein 0.0042 0.0197 0.0454
Trichomonas vaginalis hypothetical protein 0.0223 0.1287 1
Schistosoma mansoni pyruvate kinase 0.0034 0.0151 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0008 0.003
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0055 0.028
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0151 0.0521
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0015 0.0037 0.0237
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0055 0.038
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0026 0.0104 0.0373
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0026 0.0104 0.0758
Echinococcus multilocularis tumor protein p63 0.0346 0.2024 0.2023
Onchocerca volvulus 0.031 0.1804 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0055 0.0175
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0032 0.0094
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0051 0.0349
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0152 0.1044
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0032 0.0196
Schistosoma mansoni pyruvate dehydrogenase 0.0446 0.2622 0.6253
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0032 0.006
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0007 0.0000026917
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0008 0.003
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0151 0.1129
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0373
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0259 0.1974
Loa Loa (eye worm) hypothetical protein 0.0101 0.0551 0.1984
Schistosoma mansoni cpg binding protein 0.0031 0.0133 0.0302
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0089 0.1515
Schistosoma mansoni endoplasmin 0.0026 0.0104 0.0232
Brugia malayi ecdysteroid receptor 0.001 0.0008 0.003
Echinococcus granulosus cpg binding protein 0.0031 0.0133 0.0315
Leishmania major hypothetical protein, conserved 0.0026 0.0104 0.0262
Onchocerca volvulus 0.0015 0.0037 0.0168
Loa Loa (eye worm) hypothetical protein 0.0036 0.0164 0.059
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0015 0.0037 0.0109
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0008 0.0008
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0026 0.0104 0.0758
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0151 0.0544
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0026 0.0104 0.0246
Schistosoma mansoni hypothetical protein 0.0037 0.0167 0.0384
Brugia malayi Cytochrome P450 family protein 0.0018 0.0055 0.0199
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0037 0.0237
Echinococcus multilocularis muscleblind protein 0.0153 0.0865 0.0864
Echinococcus multilocularis pyruvate kinase 0.0034 0.0151 0.015
Loa Loa (eye worm) hypothetical protein 0.0049 0.0238 0.0855
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0024
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0055 0.0175
Leishmania major developmentally regulated phosphoprotein-like protein 0.0472 0.278 1
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0032 0.0094
Loa Loa (eye worm) hypothetical protein 0.0242 0.14 0.5037
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0109 0.037
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0104 0.035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0104 0.0373
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0223 0.1287 1
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0026 0.0104 0.0758
Onchocerca volvulus 0.0014 0.0032 0.0139
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0055 0.038
Entamoeba histolytica hypothetical protein 0.0037 0.0167 0.2949
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0032 0.0094
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0238 0.1804
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0037 0.0237
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0151 0.1129
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0259 0.0259
Brugia malayi Cytochrome P450 family protein 0.0027 0.0109 0.0392
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0055 0.028
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0026 0.0104 0.0758
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0007 0.0000026917
Loa Loa (eye worm) hypothetical protein 0.0472 0.278 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0104 0.035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0238 0.424
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0055 0.028
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0015 0.0037 0.0109
Mycobacterium ulcerans oxidoreductase 0.0015 0.0037 0.0237
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0055 0.038
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0026 0.0104 0.0662
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0037 0.0237
Leishmania major pyruvate kinase 0.0034 0.0151 0.0435
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0037 0.0237
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0026 0.0104 0.0758
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0024
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0008 0.0018
Trypanosoma brucei heat shock protein, putative 0.0026 0.0104 0.035
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0055 0.028
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0026 0.0104 0.054
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0037 0.0135
Brugia malayi DKFZp564C0469 protein 0.001 0.0007 0.0024
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0037 0.0237
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0055 0.038
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0032 0.0196
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0015 0.0037 0.0237
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0055 0.038
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0055 0.038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0008 0.0004
Schistosoma mansoni pyruvate dehydrogenase 0.0472 0.278 0.663
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0238 0.424
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0055 0.038
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0151 0.0544
Schistosoma mansoni endoplasmin 0.0026 0.0104 0.0232
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0015 0.0037 0.0072
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.0811 0.1935
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0037 0.0133
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0032 0.0196
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0055 0.0175
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Leishmania major oxidoreductase-like protein 0.0015 0.0037 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0024
Entamoeba histolytica DNA topoisomerase II, putative 0.0026 0.0104 0.1782
Plasmodium falciparum endoplasmin, putative 0.0026 0.0104 0.0758
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0026 0.0104 0.0662
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0055 0.0175
Trypanosoma brucei pteridine reductase 1 0.0015 0.0037 0.0109
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0551 0.1984
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0472 0.278 0.2779
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.2461 0.2461
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0321 0.0751
Schistosoma mansoni cytochrome P450 0.0018 0.0055 0.0116
Trichomonas vaginalis receptor histidine kinase, putative 0.0026 0.0104 0.0758
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0008 0.003
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0164 0.1229
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0026 0.0104 0.0662
Echinococcus multilocularis heat shock protein 0.0026 0.0104 0.0103
Schistosoma mansoni patched 1 0.0043 0.0206 0.0476
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0026 0.0104 0.0662
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0037 0.0237
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0032 0.0196
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0238 0.1804
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0223 0.1287 1
Trypanosoma brucei oxidoreductase-like protein 0.0015 0.0037 0.0109
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0259 0.0912
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0055 0.038
Brugia malayi Cytochrome P450 family protein 0.0027 0.0109 0.0392
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0032 0.0196
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0015 0.0037 0.0237
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.0741
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0167 0.0167
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0008 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0032 0.0196
Echinococcus multilocularis pyruvate kinase 0.0018 0.0051 0.0051
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0008 0.0018
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.14 0.3341
Plasmodium vivax endoplasmin, putative 0.0026 0.0104 0.0758
Mycobacterium ulcerans two component sensor kinase MprB 0.0026 0.0104 0.0758
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.14 0.1399
Brugia malayi heat shock protein 90 0.0026 0.0104 0.0373
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0089 0.0321
Brugia malayi hypothetical protein 0.001 0.0007 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.003
Entamoeba histolytica hypothetical protein 0.0037 0.0167 0.2949
Echinococcus granulosus replication factor c subunit 1 0.001 0.0007 0.0014
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0032 0.0196
Schistosoma mansoni cpg binding protein 0.0029 0.0123 0.0277
Brugia malayi steroid hormone receptor 0.001 0.0008 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0008 0.003
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0008 0.003
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0026 0.0104 0.0758
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0259 0.0604
Onchocerca volvulus 0.0051 0.025 0.1355
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0551 0.1315
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0015 0.0037 0.0237
Leishmania major mitochondrial DNA topoisomerase II 0.0026 0.0104 0.0262
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0008 0.0009
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0015 0.0037 0.0237
Schistosoma mansoni heat shock protein 0.0026 0.0104 0.0232
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0865 0.0864
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Schistosoma mansoni dihydropteridine reductase 0.0015 0.0037 0.0072
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.0561 0.1325
Trypanosoma brucei protein kinase, putative 0.0052 0.0259 0.0912
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0055 0.038
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0259 0.1974
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0026 0.0104 0.0758
Schistosoma mansoni hypothetical protein 0.0018 0.0055 0.0116
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0238 0.1804
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0026 0.0104 0.0758
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0026 0.0104 0.0662
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0055 0.028
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0008 0.003
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0238 0.1804
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0015 0.0037 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0018
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0017 0.0038
Brugia malayi hypothetical protein 0.0037 0.0167 0.0602
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0026 0.0104 0.0758
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0238 0.1804
Loa Loa (eye worm) oxidoreductase 0.0015 0.0037 0.0133
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0165 0.0937 0.3354
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0055 0.038
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0007 0.0000026917
Loa Loa (eye worm) TOPoisomerase family member 0.0026 0.0104 0.0373
Echinococcus multilocularis protein dispatched 1 0.0049 0.0243 0.0242
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0008 0.0004
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0032 0.0196
Brugia malayi nuclear receptor NHR-88 0.001 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.0015 0.0037 0.0133
Chlamydia trachomatis oxoacy-ACP reductase 0.0015 0.0037 0.0237
Entamoeba histolytica hypothetical protein 0.0037 0.0167 0.2949
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0151 0.0804
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0055 0.028
Entamoeba histolytica heat shock protein 90, putative 0.0026 0.0104 0.1782
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0104 0.035
Mycobacterium leprae Probable two-component sensor kinase 0.0026 0.0104 0.0758
Entamoeba histolytica hypothetical protein 0.0037 0.0167 0.2949
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0114
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0472 0.278 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0032 0.009
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0472 0.278 0.2779
Echinococcus multilocularis pyruvate kinase 0.0034 0.0151 0.015
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0055 0.038
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0259 0.0912
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0104 0.0758
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0032 0.0196
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0164 0.059
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0104 0.035
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0026 0.0104 0.0758
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0008 0.003
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0259 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0026 0.0104 0.0662
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0008 0.0009
Echinococcus multilocularis heat shock protein 90 0.0026 0.0104 0.0103
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0164 0.1137
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0164 0.1229
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0015 0.0037 0.0237
Echinococcus granulosus nibrin 0.001 0.0007 0.0014
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0026 0.0104 0.0758
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0008
Echinococcus granulosus muscleblind protein 0.0153 0.0865 0.2062
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0151 0.0544
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0026 0.0104 0.0662
Schistosoma mansoni hypothetical protein 0.0049 0.0243 0.0564
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0015 0.0037 0.0135
Trypanosoma brucei heat shock protein, putative 0.0026 0.0104 0.035
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0032 0.0114
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0026 0.0104 0.035
Trypanosoma cruzi DNA topoisomerase II, putative 0.0026 0.0104 0.035
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0055 0.028
Loa Loa (eye worm) cytochrome P450 0.0018 0.0055 0.0199
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0037 0.0237
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0032 0.0196
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0018
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0104 0.0758
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0055 0.038
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0164 0.1229
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0055 0.038
Chlamydia trachomatis DNA gyrase subunit B 0.0026 0.0104 0.0758
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0032 0.0094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0152 0.1044
Onchocerca volvulus 0.0014 0.0032 0.0139
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0259 0.0618
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0055 0.038
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0032 0.0114
Schistosoma mansoni hypothetical protein 0.0042 0.0197 0.0454
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0007 0.0006
Brugia malayi nuclear hormone receptor 0.001 0.0008 0.003
Echinococcus multilocularis pyruvate kinase 0.0027 0.0108 0.0107
Trypanosoma brucei Heat shock protein 83, putative 0.0026 0.0104 0.035
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Brugia malayi kinase, mitochondrial precursor 0.0472 0.278 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0015 0.0037 0.0109
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0037 0.0237
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0055 0.028
Entamoeba histolytica heat shock protein 90, putative 0.0026 0.0104 0.1782
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0032 0.0196
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0259 0.0933
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0032 0.0094
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0032 0.0196
Mycobacterium ulcerans putative regultory protein 0.0026 0.0104 0.0758
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0151 0.0521
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0551 0.0551
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0037 0.0135
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0055 0.013
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0165 0.0937 0.3354
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0151 0.0804
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0152 0.1044
Schistosoma mansoni survival motor neuron protein 0.0049 0.0243 0.0564
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0223 0.1287 1
Mycobacterium tuberculosis Conserved protein 0.0026 0.0104 0.0662
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0018
Echinococcus granulosus pyruvate kinase 0.0018 0.0051 0.0121
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0026 0.0104 0.054
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0008 0.003
Mycobacterium tuberculosis Possible two component sensor kinase 0.0026 0.0104 0.0662
Brugia malayi hypothetical protein 0.0017 0.0048 0.0172
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0055 0.038
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0026 0.0104 0.0758
Trypanosoma brucei DNA topoisomerase ii 0.0026 0.0104 0.035
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0037 0.0133
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0026 0.0104 0.0758
Trichomonas vaginalis DNA topoisomerase II, putative 0.0026 0.0104 0.0758
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0151 0.0521
Brugia malayi follicle stimulating hormone receptor 0.0237 0.137 0.493
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0037 0.0237
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0024
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0104 0.0757
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0015 0.0037 0.0109
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.003
Trypanosoma brucei heat shock protein, putative 0.0026 0.0104 0.035
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0026 0.0104 0.0758
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0165 0.0937 0.3293
Loa Loa (eye worm) hypothetical protein 0.0049 0.0238 0.0855
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0008 0.0008
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0032 0.0196
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0032 0.0196
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0238 0.0855
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0037 0.0237
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0001 0.0003
Schistosoma mansoni DNA topoisomerase II 0.0026 0.0104 0.0232
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0026 0.0104 0.0758
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0007 0.00000082407
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0151 0.1129
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0551 1
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0008 0.0008
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0037 0.0237
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0152 0.1044
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0032 0.0196
Echinococcus granulosus dnaJ subfamily B 0.0419 0.2461 0.5874
Echinococcus granulosus pyruvate kinase 0.0034 0.0151 0.0359
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0037 0.0237
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0032 0.0196
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0032 0.009
Onchocerca volvulus 0.0049 0.0238 0.1285
Schistosoma mansoni hypothetical protein 0.0012 0.0017 0.0024
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0223 0.1287 1
Mycobacterium tuberculosis Probable two component sensor kinase 0.0026 0.0104 0.0662
Leishmania major cytochrome p450-like protein 0.0027 0.0109 0.0282
Mycobacterium leprae Probable two component sensor kinase MprB 0.0026 0.0104 0.0758
Loa Loa (eye worm) hypothetical protein 0.0036 0.0164 0.059
Echinococcus multilocularis pyruvate kinase 0.0018 0.0051 0.0051
Onchocerca volvulus 0.0014 0.0032 0.0139
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0055 0.038
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0018
Brugia malayi Muscleblind-like protein 0.0153 0.0865 0.311
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0024
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0109 0.037
Chlamydia trachomatis pyruvate kinase 0.0034 0.0151 0.1129
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0055 0.028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.003
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0015 0.0037 0.0236
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0026 0.0104 0.035
Mycobacterium leprae putative cytochrome p450 0.0018 0.0055 0.038
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0104 0.0757
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0015 0.0037 0.0237
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0032 0.009
Leishmania major heat shock protein 83-1 0.0026 0.0104 0.0262
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0243 0.0873
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0109 0.08
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0055 0.038
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0151 0.1129
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0008 0.003
Schistosoma mansoni microtubule-associated protein tau 0.0707 0.4189 1
Brugia malayi hypothetical protein 0.0026 0.0104 0.0373
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0109 0.0393
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0151 0.1129
Leishmania major hypothetical protein, conserved 0.0026 0.0104 0.0262
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0008 0.0004
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0151 0.0804
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0026 0.0104 0.0373
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0055 0.028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.003
Toxoplasma gondii DNA topoisomerase 2, putative 0.0026 0.0104 0.0758
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0037 0.0237
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0015 0.0037 0.0133
Loa Loa (eye worm) hypothetical protein 0.0034 0.0151 0.0544
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0259 0.0259
Trypanosoma brucei developmentally regulated phosphoprotein 0.0472 0.278 1
Echinococcus granulosus pyruvate kinase 0.0018 0.0051 0.0121
Plasmodium falciparum pyruvate kinase 0.0034 0.0151 0.1129
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0024
Onchocerca volvulus 0.0029 0.0123 0.0646
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0015 0.0037 0.0019
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0259 0.1974
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0007 0.0024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0114

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.24 uM Inhibition of Mycobacterium tuberculosis InhA ChEMBL. 19428156

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.