Detailed information for compound 1102345

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 353.254 | Formula: C16H21BrN2O2
  • H donors: 1 H acceptors: 1 LogP: 2.63 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1C2CC[C@@H](N2C)C[C@@H]1c1ccc(c(c1)Br)N
  • InChi: 1S/C16H21BrN2O2/c1-19-10-4-6-14(19)15(16(20)21-2)11(8-10)9-3-5-13(18)12(17)7-9/h3,5,7,10-11,14-15H,4,6,8,18H2,1-2H3/t10-,11-,14?,15?/m1/s1
  • InChiKey: LDJPMOIHMAEPSX-ASNHAOSHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine transporter Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 578 aa 32.9 %
Echinococcus multilocularis sodium and chloride dependent glycine Dopamine transporter   619 aa 599 aa 41.9 %
Neospora caninum sodium-dependent transporter, putative Dopamine transporter   619 aa 498 aa 32.3 %
Onchocerca volvulus Dopamine transporter   619 aa 612 aa 23.5 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 636 aa 31.8 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Dopamine transporter   619 aa 557 aa 23.9 %
Plasmodium vivax hypothetical protein, conserved Dopamine transporter   619 aa 657 aa 20.1 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Dopamine transporter   619 aa 599 aa 44.2 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Dopamine transporter   619 aa 522 aa 36.0 %
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter Dopamine transporter   619 aa 604 aa 37.9 %
Onchocerca volvulus Transmembrane protein 120 homolog Dopamine transporter   619 aa 578 aa 32.9 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Dopamine transporter   619 aa 509 aa 40.1 %
Echinococcus granulosus sodium and chloride dependent glycine Dopamine transporter   619 aa 594 aa 41.4 %
Brugia malayi Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 578 aa 33.4 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Dopamine transporter   619 aa 551 aa 39.9 %
Schistosoma mansoni sodium/chloride dependent transporter Dopamine transporter   619 aa 558 aa 41.8 %
Schistosoma mansoni sodium/chloride dependent transporter Dopamine transporter   619 aa 588 aa 40.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0005 0.0005
Loa Loa (eye worm) serotonin transporter b 0.0109 0.0072 0.0072
Mycobacterium tuberculosis Probable lipase LipD 0.0182 0.0126 0.0107
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0011 0.0288
Entamoeba histolytica hypothetical protein 0.0107 0.007 0.0065
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0008 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Trichomonas vaginalis ran, putative 0.0021 0.0007 0.0173
Schistosoma mansoni rab6-interacting 0.002 0.0005 0.0002
Loa Loa (eye worm) norepinephrine transporter 0.0109 0.0072 0.0072
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0019 0.0005 0.0004
Echinococcus granulosus Smad4 0.0017 0.0003 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.027 0.0191 0.503
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.001 0.0258
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0525 0.0381 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0109 0.0072 0.0072
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0018 0.0017
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.027 0.0191 0.4957
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Brugia malayi hypothetical protein 0.0259 0.0183 0.4789
Schistosoma mansoni hypothetical protein 0.0065 0.0039 0.0035
Schistosoma mansoni ran 0.0021 0.0007 0.0003
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1586 0.117 0.1169
Echinococcus granulosus GPCR family 2 0.0065 0.0039 0.0038
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0525 0.0381 1
Onchocerca volvulus 0.0182 0.0126 0.3238
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0005 0.0001
Loa Loa (eye worm) RNA binding protein 0.0064 0.0039 0.0039
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.002 0.0407
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Schistosoma mansoni ap endonuclease 0.0039 0.002 0.0016
Brugia malayi RNA, U transporter 1 0.0082 0.0052 0.132
Echinococcus granulosus lamin 0.0028 0.0012 0.0011
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.002 0.0005 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Brugia malayi hypothetical protein 0.002 0.0005 0.0085
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0006 0.0001
Entamoeba histolytica diacylglycerol kinase, putative 0.0525 0.0381 0.0375
Brugia malayi MAP kinase sur-1 0.027 0.0191 0.5003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0012
Trypanosoma brucei Sphingosine kinase 0.0525 0.0381 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0309 0.0221 0.0221
Schistosoma mansoni diacylglycerol kinase theta 0.0525 0.0381 0.0377
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0018 0.0692
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0525 0.0381 0.0377
Schistosoma mansoni hypothetical protein 0.014 0.0095 0.0091
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0108 0.0071 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Leishmania major importin beta-1 subunit, putative 0.0024 0.0008 0.0073
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0019 0.0005 0.0004
Mycobacterium ulcerans lipase LipD 0.0182 0.0126 0.0107
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Echinococcus granulosus Diacylglycerol kinase theta 0.0525 0.0381 0.038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.0143 0.3715
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0039 0.0039
Mycobacterium tuberculosis Conserved protein 0.0182 0.0126 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Schistosoma mansoni sphingosine kinase A B 1.347 1 1
Loa Loa (eye worm) hypothetical protein 0.0525 0.0381 0.0381
Toxoplasma gondii exonuclease III APE 0.0039 0.002 0.0522
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.0131 0.0128
Loa Loa (eye worm) hypothetical protein 0.0182 0.0126 0.0126
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0005 0.0004
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0109 0.0072 0.0069
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0018 0.0017
Loa Loa (eye worm) beta-lactamase 0.0182 0.0126 0.0126
Schistosoma mansoni inositol monophosphatase 0.0108 0.0071 0.0068
Schistosoma mansoni hypothetical protein 0.0065 0.0039 0.0035
Loa Loa (eye worm) doublecortin family protein 0.002 0.0005 0.0005
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.0005 0.0001
Onchocerca volvulus 0.0028 0.0012 0.0192
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.0131 0.3403
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Entamoeba histolytica hypothetical protein, conserved 1.347 1 1
Onchocerca volvulus 0.002 0.0005 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0039 0.0035
Trypanosoma brucei target of rapamycin kinase 3, putative 0.002 0.0005 0.0144
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0231 0.0162 0.4231
Schistosoma mansoni sodium/chloride dependent transporter 0.0021 0.0006 0.0003
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0018 0.0015
Echinococcus granulosus RUN 0.002 0.0005 0.0004
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0018 0.0343
Mycobacterium tuberculosis Conserved protein 1.347 1 1
Echinococcus multilocularis inositol monophosphatase 1 0.0108 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0065 0.0039 0.0039
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0525 0.0381 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0005 0.0001
Echinococcus multilocularis neuropeptide s receptor 0.0959 0.0703 0.0703
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0008 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Echinococcus granulosus beta LACTamase domain containing family member 0.0182 0.0126 0.0125
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0039 0.0038
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0036 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.002 0.0522
Trypanosoma brucei hypothetical protein, conserved 0.0182 0.0126 0.3319
Plasmodium vivax hypothetical protein, conserved 0.0182 0.0126 0.3238
Trypanosoma cruzi diacylglycerol kinase, putative 0.0525 0.0381 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.0176 0.0176
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0108 0.0071 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0018 0.0482
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0036 0.0815
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0012 0.0258
Brugia malayi hypothetical protein 0.0026 0.001 0.0206
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.007 0.007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0008 0.0071
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0012 0.0323
Leishmania major GTP-binding protein, putative 0.0021 0.0007 0.003
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0003 0.0002
Schistosoma mansoni loxhd1 0.002 0.0005 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0036 0.0016
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.0005 0.0004
Echinococcus granulosus neuropeptide receptor A26 0.0959 0.0703 0.0703
Brugia malayi MH1 domain containing protein 0.0017 0.0003 0.0035
Echinococcus granulosus Diacylglycerol kinase zeta 0.0525 0.0381 0.038
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Echinococcus granulosus smad 0.0017 0.0003 0.0002
Echinococcus granulosus serotonin transporter 0.0109 0.0072 0.0071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0036 0.0016
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0036 0.0035
Toxoplasma gondii diacylglycerol kinase, putative 0.0525 0.0381 1
Brugia malayi diacylglycerol kinase 0.0525 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Toxoplasma gondii hypothetical protein 0.0019 0.0005 0.012
Brugia malayi Diacylglycerol kinase protein 2 0.0525 0.0381 1
Schistosoma mansoni hypothetical protein 0.0186 0.0129 0.0125
Trichomonas vaginalis bmru protein, putative 0.0525 0.0381 1
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0011 0.001
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.027 0.0191 0.0191
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0005 0.0067
Echinococcus granulosus tar DNA binding protein 0.0064 0.0039 0.0038
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0012 0.0011
Brugia malayi Doublecortin family protein 0.002 0.0005 0.0085
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0525 0.0381 0.0377
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0036 0.0016
Echinococcus multilocularis geminin 0.0186 0.0129 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.0005 0.0004
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.027 0.0191 0.503
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1166 0.0857 0.0839
Echinococcus multilocularis ceramide kinase 0.0525 0.0381 0.038
Trichomonas vaginalis D-aminoacylase, putative 0.0182 0.0126 0.3319
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0007 0.0006
Echinococcus multilocularis musashi 0.0028 0.0012 0.0011
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.002 0.0005 0.0005
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0005 0.0001
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0018 0.0015
Echinococcus multilocularis RUN 0.002 0.0005 0.0004
Entamoeba histolytica hypothetical protein 0.0107 0.007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0026 0.001 0.001
Schistosoma mansoni sodium/chloride dependent transporter 0.0109 0.0072 0.0069
Schistosoma mansoni lamin 0.0028 0.0012 0.0008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0108 0.0071 0.1753
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.0005 0.012
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0018
Brugia malayi MH1 domain containing protein 0.0017 0.0003 0.0035
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.002 0.0005 0.0144
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.0005 0.0004
Schistosoma mansoni microtubule-associated protein tau 0.2154 0.1591 0.1588
Brugia malayi beta-lactamase family protein 0.0182 0.0126 0.3283
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.002 0.0383
Toxoplasma gondii target of rapamycin (TOR), putative 0.002 0.0005 0.0144
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0008 0.0216
Echinococcus granulosus intermediate filament protein 0.0028 0.0012 0.0011
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0182 0.0126 0.0126
Schistosoma mansoni rab6-interacting 0.002 0.0005 0.0002
Schistosoma mansoni sodium-dependent amino acid transporter 0.0019 0.0005 0.0001
Entamoeba histolytica diacylglycerol kinase, putative 0.0525 0.0381 0.0375
Loa Loa (eye worm) Smad1 0.0017 0.0003 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0182 0.0126 0.3319
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0097 0.0063 0.0043
Leishmania major hypothetical protein, conserved 0.0026 0.001 0.0116
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0003 0.0003
Trichomonas vaginalis penicillin-binding protein, putative 0.0182 0.0126 0.3319
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.0183 0.0182
Schistosoma mansoni intermediate filament proteins 0.0028 0.0012 0.0008
Mycobacterium tuberculosis Probable lipase LipE 0.0182 0.0126 0.0107
Leishmania major sphingosine kinase A, B, putative 0.0525 0.0381 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.027 0.0191 0.4957
Plasmodium vivax diacylglycerol kinase, putative 0.0525 0.0381 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0525 0.0381 0.0375
Loa Loa (eye worm) inositol-1 0.0108 0.0071 0.0071
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0007 0.003
Trypanosoma cruzi Sphingosine kinase 0.0525 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.0126 0.0126
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0005 0.0067
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.002 0.0773
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.007 0.0067
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.027 0.0191 0.4957
Leishmania major hypothetical protein, conserved 0.0525 0.0381 1
Echinococcus multilocularis smad 0.0017 0.0003 0.0002
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0039 0.0967
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.0176 0.0176
Echinococcus multilocularis lamin dm0 0.0028 0.0012 0.0011
Schistosoma mansoni polycystin 1-related 0.002 0.0005 0.0002
Trichomonas vaginalis diacylglycerol kinase, putative 0.0525 0.0381 1
Schistosoma mansoni ap endonuclease 0.0039 0.002 0.0016
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.002 0.0471
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0007 0.0173
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0018 0.0017
Onchocerca volvulus 0.0053 0.003 0.0677
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0039 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0065 0.0039 0.0035
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0182 0.0126 0.0107
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.0131 0.013
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0108 0.0071 0.1753
Brugia malayi Importin beta-1 subunit 0.0029 0.0012 0.0271
Brugia malayi hypothetical protein 0.002 0.0005 0.0085
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.0005 0.012
Trypanosoma brucei hypothetical protein, conserved 0.0525 0.0381 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0005 0.0004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0039 0.0972
Mycobacterium ulcerans diacylglycerol kinase 0.0525 0.0381 0.0361
Schistosoma mansoni sphingoid long chain base kinase 1.347 1 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0525 0.0381 1
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0525 0.0381 0.0381
Leishmania major diacylglycerol kinase, putative 0.0525 0.0381 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0182 0.0126 0.0107
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.002 0.0383
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0007 0.0054
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0018 0.0017
Mycobacterium tuberculosis Conserved protein 0.0182 0.0126 0.0107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0039 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Echinococcus granulosus snurportin 1 0.0309 0.0221 0.022
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.027 0.0191 0.4957
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0012 0.0012
Echinococcus multilocularis neuropeptide receptor A26 0.0959 0.0703 0.0703
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0018 0.0482
Echinococcus multilocularis GPCR, family 2 0.0065 0.0039 0.0038
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0108 0.0071 0.1753
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0186 0.0129 0.0125
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.007 0.007
Brugia malayi diacylglycerol kinase 0.0525 0.0381 1
Mycobacterium tuberculosis Probable esterase LipL 0.0182 0.0126 0.0107
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0039 0.0038
Brugia malayi MH2 domain containing protein 0.0249 0.0176 0.4594
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0007 0.0173
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0525 0.0381 1
Trichomonas vaginalis CMGC family protein kinase 0.027 0.0191 0.503
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0011 0.0147
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0007 0.003
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.002 0.0383
Plasmodium falciparum diacylglycerol kinase, putative 0.0525 0.0381 1
Plasmodium falciparum importin beta, putative 0.0029 0.0012 0.0205
Echinococcus multilocularis mitogen activated protein kinase 0.027 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0178 0.0123 0.0123
Brugia malayi MH2 domain containing protein 0.0017 0.0003 0.0035
Loa Loa (eye worm) hypothetical protein 0.0259 0.0183 0.0183
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0525 0.0381 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Echinococcus granulosus microtubule associated protein 2 0.2154 0.1591 0.159
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0108 0.0071 0.0066
Brugia malayi Ceramide kinase 0.0525 0.0381 1
Brugia malayi hypothetical protein 0.0525 0.0381 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0108 0.0071 0.1871
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0525 0.0381 1
Brugia malayi Inositol-1 0.0108 0.0071 0.1828
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0036 0.0947
Brugia malayi beta-lactamase 0.0182 0.0126 0.3283
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0005 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0182 0.0126 0.3221
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0019 0.0005 0.5
Loa Loa (eye worm) hypothetical protein 0.0182 0.0126 0.0126
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0007 0.0006
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.0005 0.012
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0182 0.0126 0.0107
Entamoeba histolytica diacylglycerol kinase, putative 0.0525 0.0381 0.0375
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.0005 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0036 0.0033
Loa Loa (eye worm) hypothetical protein 0.0109 0.0072 0.0072
Schistosoma mansoni importin beta-1 0.0029 0.0012 0.0009
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0039 0.0039
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0108 0.0071 0.1871
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.002 0.0005 0.0005
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0039 0.0972
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0005 0.0091
Onchocerca volvulus Ceramide kinase 1 homolog 0.0525 0.0381 1
Brugia malayi Smad1 0.0017 0.0003 0.0035
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.002 0.0005 0.0005
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.0162 0.0162
Schistosoma mansoni ran 0.0021 0.0007 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.027 0.0191 0.503
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0005 0.0004
Brugia malayi intermediate filament protein 0.0028 0.0012 0.0258
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0018 0.0013
Brugia malayi TAR-binding protein 0.0064 0.0039 0.0967
Mycobacterium leprae conserved hypothetical protein 0.0182 0.0126 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.002 0.0005 0.0002
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.0005 0.0001
Leishmania major diacylglycerol kinase-like protein 0.0525 0.0381 1
Schistosoma mansoni hypothetical protein 0.0107 0.007 0.0067
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.0143 0.3715
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0039 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.0131 0.0128
Echinococcus multilocularis mitogen activated protein kinase 3 0.027 0.0191 0.0191
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0027 0.0011 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0182 0.0126 0.3221
Echinococcus granulosus importin subunit beta 1 0.0029 0.0012 0.0011
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0018 0.0343
Toxoplasma gondii ABC1 family protein 0.0182 0.0126 0.3319
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.014 0.0095 0.0095
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0525 0.0381 0.038
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.002 0.0019
Trypanosoma cruzi Sphingosine kinase 0.0525 0.0381 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0039 0.0035
Trichomonas vaginalis sphingosine kinase, putative 0.0525 0.0381 1
Mycobacterium ulcerans hypothetical protein 0.0182 0.0126 0.0107
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0011 0.0288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.0131 0.013
Mycobacterium leprae Probable lipase LipE 0.0182 0.0126 1
Loa Loa (eye worm) hypothetical protein 0.0182 0.0126 0.0126
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.0031 0.003
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0109 0.0072 0.1851
Leishmania major hypothetical protein, conserved 0.0525 0.0381 1
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0525 0.0381 0.0377
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.0005 0.0004
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0003 0.0002
Brugia malayi Eye-specific diacylglycerol kinase 0.0525 0.0381 1
Brugia malayi beta-lactamase family protein 0.0182 0.0126 0.3283
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0525 0.0381 1
Schistosoma mansoni survival motor neuron protein 0.0053 0.003 0.0027
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0003 0.0002
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0019 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0525 0.0381 0.0381
Brugia malayi RNA binding protein 0.0064 0.0039 0.0967
Schistosoma mansoni hypothetical protein 0.0053 0.003 0.0027
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.001 0.014
Loa Loa (eye worm) hypothetical protein 1.347 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0054
Schistosoma mansoni hypothetical protein 0.002 0.0005 0.0002
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.0031 0.003
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0108 0.0071 0.1871
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.001 0.0116
Loa Loa (eye worm) hypothetical protein 0.0525 0.0381 0.0381
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.0131 0.013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.0131 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.002 0.0005 0.0002
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0019 0.0005 0.0004
Mycobacterium tuberculosis Diacylglycerol kinase 0.0525 0.0381 0.0361
Onchocerca volvulus 0.0525 0.0381 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0003 0.0003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.0143 0.0143
Trypanosoma brucei diacylglycerol kinase, putative 0.0525 0.0381 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0182 0.0126 0.0107
Loa Loa (eye worm) diacylglycerol kinase 2 0.0525 0.0381 0.0381
Trichomonas vaginalis sphingosine kinase, putative 0.0525 0.0381 1
Echinococcus multilocularis snurportin 1 0.0309 0.0221 0.022
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0036 0.0035
Echinococcus multilocularis serotonin transporter 0.0109 0.0072 0.0071
Mycobacterium ulcerans esterase/lipase LipP 0.0182 0.0126 0.0107
Brugia malayi hypothetical protein 0.0107 0.007 0.1807
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.002 0.0522
Loa Loa (eye worm) hypothetical protein 0.0109 0.0072 0.0072
Mycobacterium ulcerans beta-lactamase 0.0182 0.0126 0.0107
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.001 0.0258
Trypanosoma cruzi diacylglycerol kinase, putative 0.0525 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0001
Echinococcus multilocularis microtubule associated protein 2 0.2154 0.1591 0.159
Plasmodium vivax importin-beta 2, putative 0.0029 0.0012 0.0205
Brugia malayi MH2 domain containing protein 0.0017 0.0003 0.0035
Onchocerca volvulus 0.0182 0.0126 0.3238
Loa Loa (eye worm) hypothetical protein 0.0204 0.0143 0.0143
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0011 0.0236
Leishmania major hypothetical protein, conserved 0.0182 0.0126 0.3221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.0131 0.0128
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.002 0.0407
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0005 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.001 0.014
Schistosoma mansoni inositol monophosphatase 0.0108 0.0071 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0525 0.0381 1
Entamoeba histolytica hypothetical protein 0.0107 0.007 0.0065
Schistosoma mansoni hypothetical protein 0.0309 0.0221 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0011 0.0008
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0006 0.0001
Mycobacterium tuberculosis Conserved protein 0.0182 0.0126 0.0107
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0005
Entamoeba histolytica Ran family GTPase 0.0021 0.0007 0.0001
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0012 0.0323
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0012 0.0323
Echinococcus multilocularis beta LACTamase domain containing family member 0.0182 0.0126 0.0125
Brugia malayi hypothetical protein 0.0017 0.0003 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0182 0.0126 0.3319
Echinococcus granulosus neuropeptide s receptor 0.0959 0.0703 0.0703
Trichomonas vaginalis CMGC family protein kinase 0.027 0.0191 0.503
Onchocerca volvulus 0.0182 0.0126 0.3238
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0019 0.0005 0.0004
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.001 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Entamoeba histolytica hypothetical protein 0.0107 0.007 0.0065
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0525 0.0381 1
Mycobacterium tuberculosis Probable hydrolase 0.0182 0.0126 0.0107
Trichomonas vaginalis D-aminoacylase, putative 0.0182 0.0126 0.3319
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0525 0.0381 0.038
Echinococcus multilocularis Smad4 0.0017 0.0003 0.0002
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.002 0.0005 0.0144
Mycobacterium ulcerans hypothetical protein 1.347 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.002 0.0014
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.003 0.074
Loa Loa (eye worm) hypothetical protein 0.0182 0.0126 0.0126
Onchocerca volvulus 0.0028 0.0012 0.0192
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0005 0.0004
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0018 0.0017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0039 0.0038
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0018 0.0482
Brugia malayi hypothetical protein 0.0019 0.0005 0.0067
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0018 0.0431
Schistosoma mansoni hypothetical protein 0.0065 0.0039 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Echinococcus multilocularis lamin 0.0028 0.0012 0.0011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0182 0.0126 0.3283
Onchocerca volvulus 0.002 0.0005 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0108 0.0071 0.1871
Toxoplasma gondii hypothetical protein 0.0019 0.0005 0.012
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.027 0.0191 0.4957
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.002 0.0522
Loa Loa (eye worm) hypothetical protein 0.0182 0.0126 0.0126
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.0005 0.0067
Echinococcus granulosus lamin dm0 0.0028 0.0012 0.0011
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0525 0.0381 0.038
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0178 0.0123 0.3202
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Onchocerca volvulus 0.0109 0.0072 0.1796
Trichomonas vaginalis diacylglycerol kinase, putative 0.0525 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0072 0.0072
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.002 0.002
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.027 0.0191 0.4957
Echinococcus multilocularis sphingosine kinase 1 1.347 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0182 0.0126 0.0123
Loa Loa (eye worm) ceramide kinase 0.0525 0.0381 0.0381
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0005 0.0018
Trichomonas vaginalis esterase, putative 0.0182 0.0126 0.3319
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0095 0.2445
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0005 0.0004
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0018 0.0343
Schistosoma mansoni lipoxygenase 0.002 0.0005 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0011 0.0288
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.001 0.0116
Echinococcus granulosus mitogen activated protein kinase 3 0.027 0.0191 0.0191
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.006
Echinococcus multilocularis Diacylglycerol kinase theta 0.0525 0.0381 0.038
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0018 0.0482
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.002 0.0005 0.0005
Plasmodium vivax diacylglycerol kinase, putative 0.0525 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0011
Echinococcus granulosus mitogen activated protein kinase 0.027 0.0191 0.0191
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.002 0.0019
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0108 0.0071 0.1871
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0019 0.0005 0.0067
Entamoeba histolytica hypothetical protein 0.0024 0.0008 0.0003
Echinococcus granulosus geminin 0.0186 0.0129 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.002 0.0005 0.0144
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0008 0.0216
Schistosoma mansoni lipoxygenase 0.0055 0.0031 0.0028
Plasmodium falciparum diacylglycerol kinase, putative 0.0525 0.0381 1
Trichomonas vaginalis bmru protein, putative 0.0525 0.0381 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0039 0.0038
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.0005 0.0001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0039 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.012 0.3143
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.0005 0.0001
Schistosoma mansoni lamin 0.0028 0.0012 0.0008
Schistosoma mansoni serine/threonine protein kinase 0.027 0.0191 0.0188
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0005 0.0018
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.0005 0.0004
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.027 0.0191 0.503
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.0131 0.0131
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0039 0.0039
Treponema pallidum sodium- and chloride- dependent transporter 0.0109 0.0072 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0005 0.0144
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0036 0.0033
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0525 0.0381 1
Echinococcus granulosus ceramide kinase 0.0525 0.0381 0.038
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0002 0.0002
Echinococcus granulosus inositol monophosphatase 1 0.0108 0.0071 0.007
Schistosoma mansoni diacylglycerol kinase theta 0.0525 0.0381 0.0377
Trypanosoma brucei protein kinase, putative 0.027 0.0191 0.503
Giardia lamblia Kinase, CMGC MAPK 0.027 0.0191 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.002 0.0005 0.0091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0182 0.0126 0.0123
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0018 0.0017
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.0183 0.0182

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.91 nM Concentration required to inhibit 50% of radioligand binding ([3H]-WIN 35428) to the dopamine (DA) transporter in rat ChEMBL. 8071935

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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