Detailed information for compound 112168

Basic information

Technical information
  • TDR Targets ID: 112168
  • Name: 3-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-1-p henyl-1,2,4-triazole-3,5-diamine
  • MW: 348.359 | Formula: C18H16N6O2
  • H donors: 2 H acceptors: 3 LogP: 3.24 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1c1cnco1)Nc1nn(c(n1)N)c1ccccc1
  • InChi: 1S/C18H16N6O2/c1-25-15-9-12(7-8-14(15)16-10-20-11-26-16)21-18-22-17(19)24(23-18)13-5-3-2-4-6-13/h2-11H,1H3,(H3,19,21,22,23)
  • InChiKey: MAGHWGVDYNCOSV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N3-(3-methoxy-4-oxazol-5-yl-phenyl)-1-phenyl-1,2,4-triazole-3,5-diamine
  • N3-[3-methoxy-4-(5-oxazolyl)phenyl]-1-phenyl-1,2,4-triazole-3,5-diamine
  • N3-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-1-phenyl-1,2,4-triazole-3,5-diamine
  • (5-amino-1-phenyl-1,2,4-triazol-3-yl)-(3-methoxy-4-oxazol-5-yl-phenyl)amine
  • N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-1-phenyl-1,2,4-triazole-3,5-diamine
  • N-(3-methoxy-4-oxazol-5-yl-phenyl)-1-phenyl-1,2,4-triazole-3,5-diamine
  • N-[3-methoxy-4-(5-oxazolyl)phenyl]-1-phenyl-1,2,4-triazole-3,5-diamine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma congolense GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium parvum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium berghei inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Neospora caninum hypothetical protein Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Theileria parva Inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium hominis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma japonicum ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium yoelii inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Loa Loa (eye worm) IMP dehydrogenase 1 Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma mansoni inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Babesia bovis inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium knowlesi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Toxoplasma gondii IMP dehydrogenas Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena Get druggable targets OG5_126887 All targets in OG5_126887
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0019 0.0073 0.0127
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0199 0.3372
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.0364
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0073 0.0068
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0024 0.0107 0.1457
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0073 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0064 0.0119
Brugia malayi nuclear hormone receptor family member nhr-6 0.0008 0.0005 0.001
Trypanosoma cruzi phospholipase A1, putative 0.0328 0.2029 0.3762
Mycobacterium ulcerans haloalkane dehalogenase 0.0013 0.0037 0.0139
Loa Loa (eye worm) acetylcholinesterase 1 0.0017 0.006 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0057 0.0077
Trichomonas vaginalis lipase containing protein, putative 0.0016 0.0056 0.0104
Echinococcus granulosus Ankyrin 0.0014 0.0044 0.0072
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0203 0.7471
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0089 0.0518 1
Brugia malayi Alpha/beta hydrolase 0.0013 0.0037 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0073 0.0171
Trypanosoma brucei lipase, putative 0.0016 0.0056 0.0075
Mycobacterium tuberculosis Probable thioesterase TesA 0.002 0.0083 0.0326
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0012
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0019 0.0073 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0271 0.4685
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0064 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0064 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0064 0.0119
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0013 0.0037 0.0639
Schistosoma mansoni adenoreceptor 0.0019 0.0073 0.0171
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0013 0.0037 0.0041
Echinococcus multilocularis BC026374 protein (S09 family) 0.0017 0.006 0.0055
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0413 0.0764
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.006 0.0142
Loa Loa (eye worm) lipase 0.0016 0.0056 0.0094
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0254
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0019 0.0073 0.0171
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0064 0.0149
Brugia malayi G protein-coupled receptor F59B2.13 0.0019 0.0073 0.0137
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0017 0.006 0.0113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0073 0.0171
Mycobacterium ulcerans amidase 0.0024 0.0107 0.0406
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0019 0.0073 0.0171
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0056 0.0075
Echinococcus granulosus fatty acid amide hydrolase 1 0.0024 0.0107 0.0191
Onchocerca volvulus 0.0019 0.0073 0.0127
Mycobacterium ulcerans bromoperoxidase BpoC 0.0013 0.0037 0.0139
Schistosoma mansoni acetylcholinesterase 0.0017 0.006 0.0142
Mycobacterium ulcerans hypothetical protein 0.0013 0.0037 0.0139
Schistosoma mansoni amine GPCR 0.0019 0.0073 0.0171
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0203 0.0198
Mycobacterium ulcerans haloalkane dehalogenase 0.0013 0.0037 0.0139
Onchocerca volvulus 0.0023 0.0098 0.0174
Trichomonas vaginalis ap endonuclease, putative 0.0033 0.0165 0.0309
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0203 0.037
Mycobacterium ulcerans thioesterase TesA 0.002 0.0083 0.0312
Brugia malayi hypothetical protein 0.0039 0.0199 0.0373
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0073 0.0068
Trypanosoma brucei protein kinase, putative 0.005 0.0271 0.048
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0118 0.0448
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0019 0.0073 0.0171
Echinococcus multilocularis neuropeptide FF receptor 2 0.0019 0.0073 0.0068
Schistosoma mansoni nuclear receptor 0.0008 0.0005 0.0012
Onchocerca volvulus 0.0019 0.0073 0.0127
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0078 0.1382
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0073 0.0171
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0328 0.2029 0.3797
Schistosoma mansoni hydrolase 0.0013 0.0037 0.0087
Leishmania major lipase, putative;with=GeneDB:LinJ31_V3.0860 0.0016 0.0056 0.0104
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.021 0.0392
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0064 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.0364
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0073 0.0127
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0109
Echinococcus granulosus allatostatin A receptor 0.0019 0.0073 0.0127
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0199 0.0364
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0013 0.0037 0.006
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.021 0.0392
Trypanosoma cruzi lipase domain protein, putative 0.0016 0.0056 0.0048
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0171
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0033 0.0165 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0203 0.0379
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0098 0.0174
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0073 0.0171
Echinococcus granulosus alpha 1A adrenergic receptor 0.0019 0.0073 0.0127
Schistosoma mansoni histamine h1 receptor 0.0019 0.0073 0.0171
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0019 0.0073 0.0127
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0073 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0147 0.0247
Brugia malayi ORL1-like opioid receptor 0.0019 0.0073 0.0137
Schistosoma mansoni neuropeptide receptor 0.0019 0.0073 0.0171
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0013 0.0037 0.0032
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0118 0.2107
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0109
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0043 0.0071
Echinococcus multilocularis abhydrolase domain containing 3 0.0013 0.0037 0.0032
Echinococcus multilocularis orexin receptor type 2 0.0019 0.0073 0.0068
Mycobacterium ulcerans lipase/esterase 0.0013 0.0037 0.0139
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0037 0.0139
Brugia malayi Tachykinin-like peptides receptor 99D 0.0019 0.0073 0.0137
Brugia malayi Amidase family protein 0.0024 0.0107 0.0201
Leishmania major DNA polymerase eta, putative 0.0014 0.0044 0.0081
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0072
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Trypanosoma cruzi lipase, putative 0.0016 0.0056 0.0048
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0073 0.0068
Mycobacterium tuberculosis Probable oxidoreductase 0.0013 0.0037 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0147 0.0247
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0151 0.0912 0.2141
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.0104 0.041
Echinococcus granulosus neuropeptide FF receptor 2 0.0019 0.0073 0.0127
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0019 0.0073 0.0171
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0073 0.0171
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0064 0.0058
Leishmania major hypothetical protein, conserved 0.0024 0.0107 0.0201
Schistosoma mansoni ap endonuclease 0.0033 0.0165 0.0387
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0024 0.0107 0.0423
Brugia malayi Uncoordinated protein 44 0.0014 0.0043 0.008
Leishmania major cytochrome p450-like protein 0.0012 0.003 0.0056
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0024 0.0107 0.1908
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0019 0.0073 0.0127
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0095 0.0554 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0271 0.0637
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0254
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0033 0.0165 0.0281
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0009 0.0006
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0271 0.048
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0365 0.0684
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0019 0.0073 0.0068
Schistosoma mansoni fatty-acid amide hydrolase 0.0202 0.1231 0.2888
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.0103
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0064 0.0109
Leishmania major inosine-5-monophosphate dehydrogenase 0.0095 0.0554 0.1036
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0271 0.0454
Schistosoma mansoni myosin xvIII 0.0019 0.0073 0.0171
Onchocerca volvulus 0.0328 0.2029 0.3791
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0151 0.0912 0.1699
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0012
Leishmania major hypothetical protein, conserved 0.0025 0.0111 0.0207
Echinococcus granulosus G protein coupled receptor 139 0.0019 0.0073 0.0127
Trypanosoma cruzi lipase, putative 0.0016 0.0056 0.0048
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0064 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0057 0.0077
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.021 0.0364
Onchocerca volvulus 0.0019 0.0073 0.0127
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0073 0.0127
Brugia malayi Protein kinase domain containing protein 0.0015 0.0046 0.0086
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0109 0.0429
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0013 0.0037 0.0087
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.0037 0.007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.006 0.0142
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0064 0.0149
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0019 0.0073 0.0137
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0128 0.0763 0.1419
Onchocerca volvulus 0.0039 0.0199 0.0364
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0064 0.0058
Loa Loa (eye worm) CYP4Cod1 0.0012 0.003 0.0046
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0118 0.2107
Mycobacterium ulcerans hydrolase 0.0013 0.0037 0.0139
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0013 0.0037 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0073 0.0171
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0017 0.006 0.0103
Echinococcus granulosus dro:myosuppressin receptor 0.0019 0.0073 0.0127
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0013 0.0037 0.0147
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0013 0.0037 0.006
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0073 0.0127
Onchocerca volvulus Fatty acid synthase homolog 0.0044 0.0233 0.0427
Schistosoma mansoni hypothetical protein 0.0167 0.1011 0.2373
Echinococcus granulosus orexin receptor type 2 0.0019 0.0073 0.0127
Mycobacterium ulcerans amidase 0.0024 0.0107 0.0406
Loa Loa (eye worm) hypothetical protein 0.0151 0.0912 0.1699
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0013 0.0037 0.0032
Mycobacterium ulcerans exported protease 0.0013 0.0037 0.0139
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.0364
Entamoeba histolytica lipase, putative 0.0016 0.0056 0.0254
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0118 0.0448
Mycobacterium leprae Probable exported protease 0.0013 0.0037 0.0639
Echinococcus multilocularis Ankyrin 0.0014 0.0044 0.0038
Schistosoma mansoni transcription factor LCR-F1 0.0128 0.0763 0.1789
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0073 0.0127
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0073 0.0068
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0005 0.0012
Echinococcus granulosus fmrfamide receptor 0.0019 0.0073 0.0127
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.005 0.0269 0.106
Schistosoma mansoni DNA polymerase eta 0.0014 0.0044 0.0102
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0111 0.0178
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0033 0.0165 0.016
Echinococcus multilocularis carboxylesterase 5A 0.0017 0.006 0.0055
Trypanosoma cruzi lipase, putative 0.0016 0.0056 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0056 0.0048
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.2507 0.2503
Brugia malayi Cytochrome P450 family protein 0.0012 0.003 0.0056
Schistosoma mansoni cpg binding protein 0.003 0.0143 0.0335
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Brugia malayi Lipase family protein 0.0016 0.0056 0.0104
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.021 0.0338
Mycobacterium ulcerans proline iminopeptidase PIP 0.0013 0.0037 0.0139
Echinococcus multilocularis para nitrobenzyl esterase 0.0017 0.006 0.0055
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0064 0.0149
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0066
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.0554 0.0986
Brugia malayi ecdysone receptor 0.0008 0.0005 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Echinococcus granulosus fatty acid amide hydrolase 1 0.0202 0.1231 0.2296
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Brugia malayi G-protein coupled receptor 0.0019 0.0073 0.0137
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0024 0.0107 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0019 0.0073 0.0068
Mycobacterium ulcerans carboxylesterase, LipT 0.0017 0.006 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0064 0.0119
Brugia malayi G-protein coupled receptor 0.0019 0.0073 0.0137
Onchocerca volvulus 0.0028 0.0133 0.0238
Schistosoma mansoni rab6-interacting 0.0039 0.0199 0.0468
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.0364
Leishmania major hypothetical protein, unknown function 0.0016 0.0056 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0073 0.0171
Loa Loa (eye worm) fatty acid synthase 0.0024 0.0107 0.019
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0064 0.0149
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0203 0.0198
Brugia malayi Carboxylesterase family protein 0.0017 0.006 0.0113
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0365 0.4523
Echinococcus multilocularis abhydrolase domain containing protein 0.0013 0.0037 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0073 0.0068
Loa Loa (eye worm) TYRA-2 protein 0.0019 0.0073 0.0127
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0044 0.0072
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0044 0.0072
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0017 0.006 0.0239
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0046 0.0248 0.0464
Schistosoma mansoni netrin receptor unc5 0.0014 0.0043 0.0101
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0199 0.0194
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0073 0.0127
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0005 0.0012
Echinococcus granulosus acetylcholinesterase 0.0017 0.006 0.0103
Schistosoma mansoni cpg binding protein 0.003 0.0143 0.0335
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0013 0.0037 0.0639
Schistosoma mansoni hypothetical protein 0.0011 0.0024 0.0056
Onchocerca volvulus 0.0019 0.0073 0.0127
Loa Loa (eye worm) hypothetical protein 0.0436 0.2719 0.5082
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0024 0.0019
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0013 0.0037 0.0041
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0073 0.0127
Onchocerca volvulus 0.0017 0.006 0.0103
Mycobacterium ulcerans hypothetical protein 0.0013 0.0037 0.0139
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0254
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.0364
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0064 0.0149
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0109 0.1932
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0013 0.0037 0.0032
Echinococcus multilocularis G-protein coupled receptor, putative 0.0019 0.0073 0.0068
Mycobacterium ulcerans oxidoreductase 0.0013 0.0037 0.0139
Mycobacterium ulcerans epoxide hydrolase EphE 0.0013 0.0037 0.0139
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0109
Brugia malayi hypothetical protein 0.0019 0.0073 0.0137
Brugia malayi hypothetical protein 0.0019 0.0073 0.0137
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0024 0.0107 0.1908
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0033 0.0165 0.2659
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0073 0.0068
Entamoeba histolytica lipase, putative 0.0016 0.0056 0.0254
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0073 0.0171
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0019 0.0073 0.0171
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0013 0.0037 0.0147
Echinococcus multilocularis serotonin receptor 0.0019 0.0073 0.0068
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.002 0.0083 0.1463
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0271 0.0508
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0019 0.0073 0.0137
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0017 0.006 0.0055
Onchocerca volvulus 0.0019 0.0073 0.0127
Loa Loa (eye worm) lipase 0.0851 0.5345 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0056 0.021
Echinococcus granulosus 7TM GPCR rhodopsin 0.0019 0.0073 0.0127
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0073 0.0127
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0073 0.0127
Schistosoma mansoni neuropeptide receptor 0.0019 0.0073 0.0171
Leishmania major DNA polymerase kappa, putative 0.0021 0.0085 0.0159
Entamoeba histolytica lipase, putative 0.0016 0.0056 0.0254
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0073 0.0127
Schistosoma mansoni nuclear receptor nhr-48 0.0008 0.0005 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0064 0.0109
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0089 0.0518 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0364
Schistosoma mansoni neuropeptide F-like receptor 0.0019 0.0073 0.0171
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0037 0.0014
Echinococcus granulosus g protein coupled receptor 0.0019 0.0073 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0085 0.013
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0019 0.0073 0.0171
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0851 0.5345 0.5343
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Brugia malayi hypothetical protein 0.0128 0.0763 0.1427
Trypanosoma cruzi lipase domain protein, putative 0.0016 0.0056 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Brugia malayi ecdysteroid receptor 0.0017 0.0064 0.0119
Trypanosoma brucei triacylglycerol lipase, putative 0.0016 0.0056 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.0364
Brugia malayi Death domain containing protein 0.0014 0.0043 0.008
Echinococcus granulosus abhydrolase domain containing protein 16A 0.0147 0.0886 0.1649
Brugia malayi nuclear receptor NHR-67 0.0008 0.0005 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0851 0.5345 1
Loa Loa (eye worm) GMP reductase 0.0039 0.0203 0.037
Onchocerca volvulus 0.0328 0.2029 0.3791
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0064 0.0119
Leishmania major hypothetical protein, conserved 0.0016 0.0056 0.0104
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0109 0.0203
Schistosoma mansoni fatty-acid amide hydrolase 0.0024 0.0107 0.0252
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0033 0.0165 0.0309
Brugia malayi amidase 0.0202 0.1231 0.2303
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0111 0.1659
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0013 0.0037 0.0032
Loa Loa (eye worm) hypothetical protein 0.016 0.097 0.1807
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0109 0.0429
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0095 0.0554 0.1027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0064 0.0119
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0013 0.0037 0.0147
Schistosoma mansoni neuropeptide receptor 0.0019 0.0073 0.0171
Schistosoma mansoni lipase 0.0016 0.0056 0.0131
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0024 0.0107 0.0102
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0186 0.3326
Brugia malayi neuropeptide F receptor 0.0019 0.0073 0.0137
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0012 0.0006
Echinococcus multilocularis neuropeptide s receptor 0.0019 0.0073 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0073 0.0127
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0019 0.0073 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0019 0.0073 0.0068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0073 0.0068
Schistosoma mansoni amine GPCR 0.0019 0.0073 0.0171
Mycobacterium ulcerans short chain dehydrogenase 0.0013 0.0037 0.0139
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0095 0.0554 0.0549
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0008 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0019 0.0073 0.0068
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0109
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.0103
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0044 0.0081
Loa Loa (eye worm) hypothetical protein 0.0147 0.0887 0.1651
Echinococcus multilocularis acetylcholinesterase 0.0017 0.006 0.0055
Mycobacterium ulcerans DNA polymerase IV 0.004 0.021 0.0797
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Echinococcus granulosus neuropeptides capa receptor 0.0019 0.0073 0.0127
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.0103
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.0012 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0271 0.0508
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0008 0.0005 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0064 0.0058
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0365 0.0631
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.005 0.0269 0.483
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0064 0.0119
Loa Loa (eye worm) amidase 0.0024 0.0107 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0013 0.0037 0.0147
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.0103
Loa Loa (eye worm) hypothetical protein 0.0151 0.0912 0.1699
Trypanosoma cruzi phospholipase A2-like protein, putative 0.015 0.0905 0.1647
Echinococcus granulosus RUN 0.0039 0.0199 0.0364
Brugia malayi Dopamine receptor 0.0019 0.0073 0.0137
Brugia malayi hypothetical protein 0.0016 0.0055 0.0103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0109
Brugia malayi nuclear receptor NHR-88 0.0017 0.0064 0.0119
Echinococcus granulosus abhydrolase domain containing protein 3 0.0013 0.0037 0.006
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0293 0.5091
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0064 0.0119
Brugia malayi nuclear hormone receptor 0.0017 0.0064 0.0119
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.0103
Brugia malayi Doublecortin family protein 0.0039 0.0199 0.0373
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0109 0.0411
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0073 0.0068
Brugia malayi tailless protein 0.0008 0.0005 0.001
Schistosoma mansoni amine GPCR 0.0019 0.0073 0.0171
Brugia malayi Lipase family protein 0.0016 0.0056 0.0104
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0033 0.0165 0.0254
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0073 0.0068
Loa Loa (eye worm) MH2 domain-containing protein 0.0095 0.0555 0.1029
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0073 0.0068
Mycobacterium tuberculosis Conserved hypothetical protein 0.0014 0.0044 0.0172
Echinococcus multilocularis neuropeptide Y receptor 0.0019 0.0073 0.0068
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0024 0.0107 0.0423
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.003 0.0046
Brugia malayi hypothetical protein 0.0019 0.0073 0.0137
Trichomonas vaginalis lipase containing protein, putative 0.0851 0.5345 1
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0012 0.0022
Trichomonas vaginalis spcc417.12 protein, putative 0.0017 0.006 0.0113
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0008 0.0005 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0064 0.0109
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0013 0.0037 0.0147
Onchocerca volvulus Lipase homolog 0.0013 0.0037 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0064 0.0109
Brugia malayi Carboxylesterase family protein 0.0017 0.006 0.0113
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0199 0.0364
Loa Loa (eye worm) hypothetical protein 0.0039 0.0203 0.037
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.001 0.0016 0.0063
Entamoeba histolytica hypothetical protein 0.0128 0.0763 1
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0024 0.0107 0.0423
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Loa Loa (eye worm) lipase 0.0016 0.0056 0.0094
Brugia malayi AKH receptor 0.0019 0.0073 0.0137
Brugia malayi Dopamine receptor protein 1 0.0019 0.0073 0.0137
Echinococcus granulosus neuropeptide Y receptor 0.0019 0.0073 0.0127
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0044 0.0026
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0073 0.0127
Loa Loa (eye worm) hypothetical protein 0.0436 0.2719 0.5082
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0073 0.0171
Schistosoma mansoni lipoxygenase 0.0039 0.0199 0.0468
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0203 0.0476
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0098 0.0184
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0014 0.0042 0.0164
Echinococcus granulosus carboxylesterase 5A 0.0017 0.006 0.0103
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0012 0.0032 0.0175
Onchocerca volvulus 0.0019 0.0073 0.0127
Loa Loa (eye worm) acyl carrier protein 0.0011 0.0025 0.0036
Trypanosoma brucei cytochrome P450, putative 0.0012 0.003 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0064 0.0109
Schistosoma mansoni neuropeptide receptor 0.0019 0.0073 0.0171
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0064 0.0149
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0171
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0019 0.0073 0.0068
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0039 0.0203 0.0379
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0089 0.0518 0.1976
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Echinococcus granulosus g protein coupled receptor 0.0019 0.0073 0.0127
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0203 0.0379
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0064 0.0109
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0054 0.0595
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0254
Leishmania major lipase precursor-like protein 0.0016 0.0056 0.0104
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0095 0.0554 0.2112
Brugia malayi polk-prov protein 0.0031 0.0147 0.0276
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.008 0.0317
Echinococcus multilocularis RUN 0.0039 0.0199 0.0194
Treponema pallidum exodeoxyribonuclease (exoA) 0.0033 0.0165 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0064 0.0119
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.0103
Echinococcus granulosus neuropeptide s receptor 0.0019 0.0073 0.0127
Schistosoma mansoni hypothetical protein 0.0039 0.0199 0.0468
Brugia malayi hypothetical protein 0.0019 0.0073 0.0137
Onchocerca volvulus 0.0016 0.0056 0.0094
Onchocerca volvulus 0.0436 0.2719 0.5082
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0073 0.0127
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0203 0.0325
Entamoeba histolytica hypothetical protein 0.0128 0.0763 1
Echinococcus granulosus hypothetical protein 0.0019 0.0073 0.0127
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0045 0.0238 0.0907
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0033 0.0165 0.0627
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0064 0.0109
Mycobacterium ulcerans epoxide hydrolase EphF 0.0013 0.0037 0.0139
Echinococcus granulosus rhodopsin orphan GPCR 0.0019 0.0073 0.0127
Trypanosoma cruzi hydrolase-like protein 0.0013 0.0037 0.0014
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0013 0.0037 0.0147
Echinococcus granulosus abhydrolase domain containing protein 11 0.0013 0.0037 0.006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Schistosoma mansoni ap endonuclease 0.0033 0.0165 0.0387
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Schistosoma mansoni biogenic amine receptor 0.0019 0.0073 0.0171
Onchocerca volvulus 0.0019 0.0073 0.0127
Trypanosoma cruzi Triglyceride lipase, putative 0.0016 0.0056 0.0048
Trypanosoma cruzi lipase, putative 0.0016 0.0056 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Brugia malayi GMP reductase 0.0039 0.0203 0.0379
Leishmania major hypothetical protein, conserved 0.0013 0.0037 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0073 0.0068
Toxoplasma gondii alpha/beta hydrolase, putative 0.0013 0.0037 0.0279
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0005
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0271 0.0266
Brugia malayi Amidase family protein 0.0024 0.0107 0.0201
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Schistosoma mansoni zinc finger protein 0.0008 0.0005 0.0012
Mycobacterium ulcerans hypothetical protein 0.0013 0.0037 0.0139
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0064 0.0149
Echinococcus multilocularis fmrfamide receptor 0.0019 0.0073 0.0068
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0095 0.0554 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0078 0.0295
Onchocerca volvulus 0.0017 0.006 0.0103
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0202 0.1231 0.1226
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0016 0.0056 0.005
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0111 0.1525
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0044 0.0102
Echinococcus granulosus BC026374 protein S09 family 0.0017 0.006 0.0103
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0019 0.0073 0.0127
Schistosoma mansoni neuroligin 3 (S09 family) 0.0017 0.006 0.0142
Mycobacterium ulcerans amidase 0.0024 0.0107 0.0406
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0199 0.0364
Schistosoma mansoni gliotactin 0.0017 0.006 0.0142
Leishmania major hydrolase, alpha/beta fold family, putative 0.0013 0.0037 0.007
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0365 0.0857
Leishmania major hydrolase-like protein,esterase-like protein 0.0013 0.0037 0.007
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0109 0.0411
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0254
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0043 0.0101
Loa Loa (eye worm) neuropeptide F receptor 0.0019 0.0073 0.0127
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0065 0.0256
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0019 0.0073 0.0137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Brugia malayi CXXC zinc finger family protein 0.0028 0.0133 0.0248
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0064 0.0058
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0271 0.0266
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0064 0.0149
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0033 0.0165 0.1762
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0199 0.0364
Onchocerca volvulus Neuropeptide F receptor homolog 0.0019 0.0073 0.0127
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0056 0.0048
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0118 0.0467
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0271 0.0508
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0365 0.0657
Leishmania major hydrolase-like protein 0.0013 0.0037 0.007
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0171
Brugia malayi Carboxylesterase family protein 0.0017 0.006 0.0113
Trypanosoma brucei lipase domain protein, putative 0.0016 0.0056 0.0075
Onchocerca volvulus 0.0019 0.0073 0.0127
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0073 0.0068
Onchocerca volvulus Putative GMP reductase 0.0039 0.0203 0.037
Onchocerca volvulus 0.0019 0.0073 0.0127
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0186 0.0732
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.021 0.0338
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.016 0.097 0.1815
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.0037 0.007
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0019 0.0073 0.0068
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0271 0.0508
Leishmania major hypothetical protein, conserved 0.0013 0.0037 0.007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0271 0.0454
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0203 0.037
Schistosoma mansoni neuropeptide f receptor 76f 0.0019 0.0073 0.0171
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0013 0.0037 0.0139
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0203 0.0351
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Schistosoma mansoni opsin-like receptor 0.0019 0.0073 0.0171
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0019 0.0073 0.0127
Loa Loa (eye worm) hypothetical protein 0.0013 0.0037 0.006
Echinococcus granulosus para nitrobenzyl esterase 0.0017 0.006 0.0103
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0019 0.0073 0.0171
Brugia malayi larval opioid receptor 0.0019 0.0073 0.0137
Onchocerca volvulus 0.0016 0.0056 0.0094
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Mycobacterium ulcerans peptide amidase, GatA 0.0024 0.0107 0.0406
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.021 0.0338
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0012 0.0027
Schistosoma mansoni hypothetical protein 0.0014 0.0043 0.0101
Onchocerca volvulus 0.0043 0.0224 0.0409
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0151 0.0912 0.0908
Echinococcus granulosus death domain containing protein 0.0014 0.0043 0.0071
Onchocerca volvulus 0.0147 0.0887 0.1651
Echinococcus multilocularis g-protein coupled receptor 0.0019 0.0073 0.0068
Echinococcus multilocularis dna polymerase kappa 0.004 0.021 0.0204
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0073 0.0127
Brugia malayi alpha/beta hydrolase 0.0013 0.0037 0.007
Schistosoma mansoni microtubule-associated protein tau 0.068 0.4262 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.006 0.0142
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0045 0.0238 0.4285
Brugia malayi UPF0017 protein CG3488 0.0013 0.0037 0.007
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0008 0.0005 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Toxoplasma gondii homoserine O-acetyltransferase, putative 0.0013 0.0037 0.0279
Onchocerca volvulus 0.0017 0.006 0.0103
Echinococcus multilocularis somatostatin receptor 0.0019 0.0073 0.0068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0043 0.0038
Brugia malayi Nuclear hormone receptor E75 0.0008 0.0005 0.001
Trypanosoma cruzi lipase, putative 0.0016 0.0056 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0064 0.0109
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.0103
Brugia malayi hypothetical protein 0.0009 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0019 0.0073 0.0127
Leishmania major serine peptidase, putative,serine peptidase, Clan SC, Family S9D 0.0013 0.0037 0.007
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0118 0.0467
Brugia malayi Lipase family protein 0.0851 0.5345 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.0554 0.0986
Echinococcus granulosus 7tm_1 domain containing protein 0.0019 0.0073 0.0127
Echinococcus granulosus neuropeptide receptor 0.0019 0.0073 0.0127
Onchocerca volvulus 0.0019 0.0073 0.0127
Brugia malayi hypothetical protein 0.0019 0.0073 0.0137
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0043 0.0071
Schistosoma mansoni coup transcription factor 0.0017 0.0064 0.0149
Leishmania major lipase, putative 0.0016 0.0056 0.0104
Brugia malayi exodeoxyribonuclease III family protein 0.0033 0.0165 0.0309
Schistosoma mansoni biogenic amine receptor 0.0019 0.0073 0.0171
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0118 0.2107
Brugia malayi steroid hormone receptor 0.0017 0.0064 0.0119
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0365 0.0684
Onchocerca volvulus 0.0019 0.0073 0.0127
Onchocerca volvulus 0.0017 0.0064 0.0109
Trypanosoma cruzi GMP reductase 0.0095 0.0554 0.0986
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0203 0.0325
Leishmania major lipase domain protein, putative 0.0016 0.0056 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0056 0.0048
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0064 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0064 0.0119
Mycobacterium ulcerans amidase 0.0024 0.0107 0.0406
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0008 0.0015
Giardia lamblia hypothetical protein 0.0016 0.0056 0.2051
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0271 0.0498
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0109
Brugia malayi nuclear receptor NHR-88 0.0008 0.0005 0.001
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0024 0.0107 0.0102
Echinococcus multilocularis Protein lozenge 0.0055 0.03 0.0295
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0019 0.0073 0.0068
Mycobacterium ulcerans epoxide hydrolase EphB 0.0013 0.0037 0.0139
Toxoplasma gondii exonuclease III APE 0.0033 0.0165 0.2685
Schistosoma mansoni BC026374 protein (S09 family) 0.0017 0.006 0.0142
Schistosoma mansoni nuclear receptor 0.0008 0.0005 0.0012
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0033 0.0165 0.2659
Brugia malayi nuclear receptor RXR 0.0008 0.0005 0.001
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0008 0.0007 0.0026
Loa Loa (eye worm) hydrolase 0.0013 0.0037 0.006
Schistosoma mansoni polycystin 1-related 0.0039 0.0199 0.0468
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0001 0.0002
Brugia malayi putative amidase 0.0024 0.0107 0.0201
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.021 0.0338
Echinococcus multilocularis g protein coupled receptor 0.0019 0.0073 0.0068
Trypanosoma brucei Triglyceride lipase, putative 0.0016 0.0056 0.0075
Schistosoma mansoni loxhd1 0.0039 0.0199 0.0468
Echinococcus granulosus sex peptide receptor 0.0019 0.0073 0.0127
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0039 0.0203 0.0379
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.021 0.0364
Brugia malayi MH2 domain containing protein 0.0095 0.0555 0.1037
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0109
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0024 0.0107 0.1457
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0056 0.0383
Echinococcus multilocularis cpg binding protein 0.003 0.0143 0.0138
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0271 0.0508
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.0037 0.007
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.0104 0.041
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0203 0.2281
Brugia malayi neuropeptide F receptor 0.0019 0.0073 0.0137
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0271 0.0508
Leishmania major hypothetical protein, unknown function 0.0016 0.0056 0.0104
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0095 0.0554 0.0986
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0202 0.1231 0.1226
Leishmania major class 3 lipase, putative 0.0016 0.0056 0.0104
Mycobacterium tuberculosis 4,9-DHSA hydrolase 0.0407 0.2534 1
Trypanosoma cruzi GMP reductase 0.0095 0.0554 0.0986
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0044 0.0081
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0024 0.0107 0.0252
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0095 0.0554 0.2186
Leishmania major hydrolase, alpha/beta fold family-like protein 0.0013 0.0037 0.007
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0095 0.0554 0.101
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0016 0.0056 0.0978
Echinococcus granulosus dna polymerase eta 0.0014 0.0044 0.0072
Brugia malayi hypothetical protein 0.0019 0.0073 0.0137
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0109 0.0429
Onchocerca volvulus 0.0851 0.5345 1
Brugia malayi hypothetical protein 0.0019 0.0073 0.0137
Toxoplasma gondii IMP dehydrogenas 0.0095 0.0554 1
Echinococcus granulosus somatostatin receptor 0.0019 0.0073 0.0127
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0073 0.0171
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.003 0.0046
Echinococcus granulosus dna polymerase kappa 0.004 0.021 0.0383
Brugia malayi Melatonin receptor type 1A 0.0019 0.0073 0.0137
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0199 0.0194
Mycobacterium ulcerans fatty acid synthase Fas 0.0008 0.0002 0.0004
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0085 0.0159
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0203 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0044 0.0102
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0064 0.0058
Loa Loa (eye worm) hypothetical protein 0.0041 0.0214 0.0392
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0033 0.0165 0.0651
Brugia malayi Carboxylesterase family protein 0.0017 0.006 0.0113
Trypanosoma cruzi lipase, putative 0.0016 0.0056 0.0048
Toxoplasma gondii type I fatty acid synthase, putative 0.0017 0.0064 0.0779
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0019 0.0073 0.0127
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0019 0.0073 0.0068
Echinococcus granulosus neuropeptide receptor A26 0.0019 0.0073 0.0127
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.0103
Trypanosoma cruzi phospholipase A1, putative 0.0328 0.2029 0.3762
Echinococcus multilocularis sex peptide receptor 0.0019 0.0073 0.0068
Mycobacterium ulcerans hydrolase 0.0013 0.0037 0.0139
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0118 0.0467
Brugia malayi GnHR receptor homolog 0.0019 0.0073 0.0137
Brugia malayi Lipase family protein 0.0016 0.0056 0.0104
Brugia malayi Protein C20orf22 0.0151 0.0912 0.1707
Brugia malayi Lipase family protein 0.0016 0.0056 0.0104
Leishmania major hypothetical protein, conserved 0.0016 0.0056 0.0104
Echinococcus multilocularis dna polymerase eta 0.0014 0.0044 0.0038
Schistosoma mansoni biogenic amine receptor 0.0019 0.0073 0.0171
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0019 0.0073 0.0127
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0044 0.0087
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0064 0.0119
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0064 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.0364
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0013 0.0037 0.006
Trypanosoma brucei phospholipase A1, putative 0.0328 0.2029 0.3779
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0064 0.0058
Entamoeba histolytica hypothetical protein 0.0128 0.0763 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0043 0.008
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0111 0.1525
Mycobacterium ulcerans polyketide synthase 0.0025 0.0109 0.0411
Brugia malayi Carboxylesterase family protein 0.0017 0.006 0.0113
Echinococcus multilocularis allatostatin A receptor 0.0019 0.0073 0.0068
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0013 0.0037 0.0639
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0203 0.0198
Trypanosoma cruzi lipase-like protein, putative 0.0016 0.0056 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Brugia malayi small heat shock protein 0.0569 0.356 0.6661
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.0103
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0064 0.0109
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0254
Onchocerca volvulus 0.0017 0.006 0.0103
Loa Loa (eye worm) amidase 0.0024 0.0107 0.0191
Echinococcus granulosus g protein coupled receptor 0.0019 0.0073 0.0127
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Mycobacterium ulcerans lipase/esterase 0.0013 0.0037 0.0139
Toxoplasma gondii lipase 0.0016 0.0056 0.0625
Echinococcus multilocularis neuropeptide receptor A26 0.0019 0.0073 0.0068
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0013 0.0037 0.0147
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0064 0.0119
Brugia malayi hypothetical protein 0.0019 0.0073 0.0137
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.0037 0.007
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0019 0.0073 0.0137
Mycobacterium ulcerans peroxidase BpoB 0.0013 0.0037 0.0139
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0197
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.042 0.2618 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0365 0.036
Schistosoma mansoni hypothetical protein 0.0128 0.0763 0.1789
Echinococcus granulosus serotonin receptor 0.0019 0.0073 0.0127
Echinococcus granulosus dnaJ subfamily B 0.0403 0.2507 0.4686
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0203 0.0379
Onchocerca volvulus 0.0019 0.0073 0.0127
Loa Loa (eye worm) carboxylesterase 0.0017 0.006 0.0103
Brugia malayi follicle stimulating hormone receptor 0.0019 0.0073 0.0137
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Schistosoma mansoni protein bat5 (S09 family) 0.0147 0.0886 0.2079
Schistosoma mansoni amine GPCR 0.0019 0.0073 0.0171
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0413 0.0408
Trypanosoma cruzi amidase, putative 0.0024 0.0107 0.0145
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0019 0.0073 0.0137
Schistosoma mansoni hypothetical protein 0.0051 0.0276 0.0648
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0085 0.0334
Trypanosoma cruzi phospholipase A2-like protein, putative 0.015 0.0905 0.1647
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0064 0.0119
Trypanosoma cruzi lipase, putative 0.0016 0.0056 0.0048
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0017 0.006 0.0239
Schistosoma mansoni opsin-like receptor 0.0019 0.0073 0.0171
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Onchocerca volvulus 0.0017 0.006 0.0103
Onchocerca volvulus 0.0328 0.2029 0.3791
Echinococcus granulosus g-protein coupled receptor 0.0019 0.0073 0.0127
Echinococcus granulosus acetylcholinesterase 0.0017 0.006 0.0103
Schistosoma mansoni hypothetical protein 0.0019 0.0073 0.0171
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0064 0.0109
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0037 0.0014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0043 0.0071
Trypanosoma brucei DNA polymerase eta, putative 0.0014 0.0044 0.0053
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0851 0.5345 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0073 0.0068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0006
Echinococcus granulosus tachykinin peptides receptor 99D 0.0019 0.0073 0.0127
Brugia malayi hypothetical protein 0.0008 0.0005 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0851 0.5345 1
Trypanosoma brucei unspecified product 0.0034 0.0168 0.0287
Loa Loa (eye worm) hypothetical protein 0.0014 0.0044 0.0072
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0012
Echinococcus multilocularis acetylcholinesterase 0.0017 0.006 0.0055
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0271 0.0498
Schistosoma mansoni amine GPCR 0.0019 0.0073 0.0171
Onchocerca volvulus 0.0147 0.0887 0.1651
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.0037 0.007
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0013 0.0037 0.007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Onchocerca volvulus 0.0019 0.0073 0.0127
Onchocerca volvulus 0.0019 0.0073 0.0127
Giardia lamblia hypothetical protein 0.0016 0.0056 0.2051
Brugia malayi G protein-coupled receptor 0.0019 0.0073 0.0137
Loa Loa (eye worm) carboxylesterase 0.0017 0.006 0.0103
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0013 0.0037 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0064 0.0119
Brugia malayi Cytochrome P450 family protein 0.0012 0.003 0.0056
Schistosoma mansoni growth hormone secretagogue receptor 0.0019 0.0073 0.0171
Schistosoma mansoni hypothetical protein 0.0167 0.1011 0.2373
Mycobacterium leprae Probable exported protease 0.0013 0.0037 0.0639
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0019 0.0073 0.0068
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0098 0.0388
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0019 0.0073 0.0171
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0328 0.2029 0.3791
Loa Loa (eye worm) melatonin receptor type 1A 0.0019 0.0073 0.0127
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0192 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0064 0.0119
Trypanosoma cruzi hydrolase-like protein, putative 0.0013 0.0037 0.0014
Brugia malayi MAP kinase sur-1 0.005 0.0271 0.0508
Loa Loa (eye worm) IMP dehydrogenase 1 0.0095 0.0554 0.1027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0334 0.0783
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0095 0.0554 0.1299
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0254
Echinococcus multilocularis neuroligin 0.0017 0.006 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0073 0.0171
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0111 0.0152
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0111 0.1525
Mycobacterium ulcerans thioesterase 0.002 0.0083 0.0312
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0064 0.0109
Trypanosoma cruzi Lipase (class 3), putative 0.0016 0.0056 0.0048
Brugia malayi RE15519p 0.0019 0.0073 0.0137
Mycobacterium ulcerans polyketide synthase Pks9 0.0016 0.0056 0.021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0073 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0073 0.0068
Trypanosoma cruzi hydrolase-like protein, putative 0.0013 0.0037 0.0014
Brugia malayi Serotonin receptor 0.0019 0.0073 0.0137
Brugia malayi hydrolase, alpha/beta fold family protein 0.0013 0.0037 0.007
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0109 0.0411
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0043 0.0038
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0012
Trypanosoma brucei Triglyceride lipase, putative 0.0016 0.0056 0.0075
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0019 0.0073 0.0127
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0168 0.0287
Onchocerca volvulus 0.0019 0.0073 0.0127
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0364
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0013 0.0037 0.0139
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0043 0.0071
Echinococcus multilocularis dro:myosuppressin receptor 0.0019 0.0073 0.0068
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0019 0.0073 0.0068
Leishmania major hydrolase-like protein,esterase-like protein 0.0013 0.0037 0.007
Echinococcus granulosus neuroligin 0.0017 0.006 0.0103
Trichomonas vaginalis hydrolase, putative 0.0013 0.0037 0.007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0008 0.0002 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0073 0.0068
Trypanosoma brucei Lipase (class 3), putative 0.0016 0.0056 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Plasmodium falciparum lipase, putative 0.0016 0.0056 0.0383
Brugia malayi Dopamine receptor protein 2 0.0019 0.0073 0.0137
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0078 0.0295
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0064 0.0109
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0024 0.0107 0.0423
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0064 0.0119
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0024 0.0107 0.0423
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0365 0.0631
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0013 0.0037 0.0147
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0044 0.0103
Echinococcus multilocularis G protein coupled receptor 139 0.0019 0.0073 0.0068
Onchocerca volvulus Lipase homolog 0.0013 0.0037 0.006
Brugia malayi hydrolase, alpha/beta fold family protein 0.0013 0.0037 0.007
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0271 0.0454
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0012 0.0022
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0133 0.0238
Echinococcus granulosus geminin 0.0167 0.1011 0.1884
Mycobacterium tuberculosis Carboxylesterase LipT 0.0017 0.006 0.0239
Trypanosoma cruzi lipase, putative 0.0016 0.0056 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Echinococcus granulosus peptide allatostatin:somatostatin 0.0019 0.0073 0.0127
Echinococcus multilocularis microtubule associated protein 2 0.068 0.4262 0.4259
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0118 0.1804
Brugia malayi hypothetical protein 0.0436 0.2719 0.5087
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0365 0.0674
Mycobacterium ulcerans hypothetical protein 0.0013 0.0037 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0033 0.0165 0.1294
Echinococcus granulosus microtubule associated protein 2 0.068 0.4262 0.7973
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0199 0.3372
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0186 0.0705
Brugia malayi putative neuropeptide receptor 0.0019 0.0073 0.0137
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0064 0.0109
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Trypanosoma cruzi amidase, putative 0.0024 0.0107 0.0145
Schistosoma mansoni opsin-like receptor 0.0019 0.0073 0.0171
Brugia malayi nuclear receptor RXR 0.0009 0.0012 0.0022
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0064 0.0109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0064 0.0109
Brugia malayi hypothetical protein 0.0009 0.0012 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0073 0.0171
Toxoplasma gondii lipase 0.0016 0.0056 0.0625
Brugia malayi hypothetical protein 0.0008 0.0005 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0057 0.0077
Leishmania major hypothetical protein, conserved 0.0851 0.5345 1
Brugia malayi hypothetical protein 0.0019 0.0073 0.0137
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.016 0.097 0.0965
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0017 0.006 0.0142
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0019 0.0073 0.0127
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0019 0.0073 0.0171
Brugia malayi hypothetical protein 0.0017 0.006 0.0113
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0128 0.0763 0.0758
Giardia lamblia ENC6 protein 0.0013 0.0037 0.1372
Brugia malayi hypothetical protein 0.0025 0.0111 0.0207
Schistosoma mansoni cpg binding protein 0.0028 0.0133 0.0311
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0019 0.0073 0.0171
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0271 0.0498
Schistosoma mansoni amidase 0.0202 0.1231 0.2888
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0365 0.0674
Giardia lamblia DINP protein human, muc B family 0.0021 0.0085 0.3123
Brugia malayi conserved hypotetical protein 0.0008 0.0005 0.001
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0064 0.0109
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0073 0.0068
Brugia malayi nuclear hormone receptor 0.0008 0.0005 0.001
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0271 0.0454
Entamoeba histolytica hypothetical protein 0.0016 0.0056 0.0254
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0109 0.0411
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0203 0.0476
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Onchocerca volvulus 0.0039 0.0199 0.0364
Echinococcus granulosus fatty acid amide hydrolase 1 0.0202 0.1231 0.2296
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0024 0.0107 0.0172
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0033 0.0165 0.0299
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0013 0.0037 0.0147
Echinococcus multilocularis neuropeptide receptor 0.0019 0.0073 0.0068
Leishmania major guanosine monophosphate reductase 0.0095 0.0554 0.1036
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0203 0.0379
Mycobacterium tuberculosis Probable exported protease 0.0013 0.0037 0.0147
Echinococcus granulosus tm gpcr rhodopsin 0.0019 0.0073 0.0127
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0095 0.0554 0.1036
Trypanosoma brucei lipase domain protein, putative 0.0851 0.5345 1
Loa Loa (eye worm) hypothetical protein 0.0569 0.356 0.6657
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0044 0.0038
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0064 0.0149
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.003 0.0111
Loa Loa (eye worm) transcription factor SMAD2 0.0095 0.0555 0.1029
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.0364
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0024 0.0107 0.0191
Loa Loa (eye worm) carboxylesterase 0.0017 0.006 0.0103
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0199 0.0194
Entamoeba histolytica lipase, putative 0.0016 0.0056 0.0254
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0266
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0012 0.0012
Toxoplasma gondii lipase 0.0016 0.0056 0.0625
Onchocerca volvulus 0.0147 0.0886 0.1649
Loa Loa (eye worm) hypothetical protein 0.0202 0.1231 0.2296
Entamoeba histolytica hypothetical protein 0.0128 0.0763 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0.0037 0.007
Loa Loa (eye worm) G-protein coupled receptor 0.0019 0.0073 0.0127
Brugia malayi hypothetical protein 0.0039 0.0199 0.0373
Loa Loa (eye worm) runx1 0.0055 0.03 0.0552
Trichomonas vaginalis ap endonuclease, putative 0.0033 0.0165 0.0309
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0013 0.0037 0.0147
Mycobacterium ulcerans DNA polymerase IV 0.004 0.021 0.0797
Echinococcus granulosus neuropeptide receptor 0.0019 0.0073 0.0127
Brugia malayi sulfakinin receptor protein 0.0019 0.0073 0.0137
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0013 0.0037 0.0639
Giardia lamblia Hypothetical protein 0.0016 0.0056 0.2051
Mycobacterium ulcerans amidase 0.0024 0.0107 0.0406
Leishmania major phospholipase A1, putative 0.0328 0.2029 0.3797
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0064 0.0149
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0064 0.0149
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Toxoplasma gondii lipase 0.0016 0.0056 0.0625
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.0012 0.0027
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0186 0.0732
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0056 0.0104
Brugia malayi orphan nuclear receptor NR2E1 0.0008 0.0005 0.001
Trichomonas vaginalis lipase containing protein, putative 0.0851 0.5345 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0019 0.0073 0.0068
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0064 0.0058
Mycobacterium ulcerans polyketide synthase 0.0026 0.0118 0.0448
Mycobacterium ulcerans lignin peroxidase LipJ 0.0013 0.0037 0.0139
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0033 0.0165 0.6084
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0064 0.0109
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0111 0.0152
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0203 0.037
Mycobacterium ulcerans epoxide hydrolase EphA 0.0013 0.0037 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0109
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0271 1
Brugia malayi Nuclear hormone receptor E75 0.0008 0.0005 0.001
Echinococcus granulosus biogenic amine 5HT receptor 0.0019 0.0073 0.0127
Mycobacterium tuberculosis Conserved protein 0.0013 0.0037 0.0147
Onchocerca volvulus 0.0016 0.0056 0.0094
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0192 0.0349
Echinococcus multilocularis serotonin receptor 0.0019 0.0073 0.0068
Trypanosoma brucei lipase-like protein, putative 0.0016 0.0056 0.0075
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0033 0.0165 0.0254
Brugia malayi putative neuropeptide receptor NPR1 0.0019 0.0073 0.0137
Loa Loa (eye worm) hypothetical protein 0.0009 0.0012 0.0012
Brugia malayi nuclear hormone receptor family member odr-7 0.0008 0.0005 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.021 0.0364
Brugia malayi Serotonin receptor 0.0019 0.0073 0.0137
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0024 0.0107 0.0406
Mycobacterium ulcerans exported protease 0.0013 0.0037 0.0139
Giardia lamblia Hypothetical protein 0.0016 0.0056 0.2051
Echinococcus granulosus cpg binding protein 0.003 0.0143 0.0257
Giardia lamblia Hypothetical protein 0.0016 0.0056 0.2051
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0037 0.0014
Schistosoma mansoni lozenge 0.0055 0.03 0.0704
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0024 0.0035
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0109 0.1932
Schistosoma mansoni hypothetical protein 0.0403 0.2507 0.5882
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Onchocerca volvulus 0.0019 0.0073 0.0127
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0043 0.0071
Echinococcus granulosus abhydrolase domain containing protein 0.0013 0.0037 0.006
Brugia malayi hypothetical protein 0.0019 0.0073 0.0137
Echinococcus multilocularis geminin 0.0167 0.1011 0.1007
Brugia malayi Carboxylesterase family protein 0.0017 0.006 0.0113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0019 0.0073 0.0068
Trypanosoma brucei lipase domain protein, putative 0.0851 0.5345 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0019 0.0073 0.0068
Schistosoma mansoni alpha-1 adrenergic receptor 0.0019 0.0073 0.0171
Leishmania major hypothetical protein, conserved 0.0016 0.0056 0.0104
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0064 0.0109
Schistosoma mansoni biogenic amine (5HT) receptor 0.0019 0.0073 0.0171
Schistosoma mansoni rab6-interacting 0.0039 0.0199 0.0468
Trypanosoma brucei GMP reductase 0.0095 0.0554 0.101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0073 0.0127
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0016 0.0056 0.0094

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 150 nM Inhibition of human Inosine-5'-monophosphate dehydrogenase 2 ChEMBL. 12127522
IC50 (binding) = 150 nM Inhibition of human Inosine-5'-monophosphate dehydrogenase 2 ChEMBL. 12127522
IC50 (binding) = 0.15 uM Inhibition of Inosine Monophosphate Dehydrogenase II (IMPDH II) ChEMBL. 12372516
IC50 (binding) = 0.15 uM Inhibition of Inosine Monophosphate Dehydrogenase II (IMPDH II) ChEMBL. 12372516
IC50 (functional) > 1 uM Inhibitory activity against human T-lymphoblast CEM cell line using T cell proliferation assay ChEMBL. 12127522
IC50 (functional) > 1 uM Inhibitory activity against human T-lymphoblast CEM cell line using T cell proliferation assay ChEMBL. 12127522

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 12127522

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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