Detailed information for compound 1130481

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 555.639 | Formula: C29H33NO8S
  • H donors: 5 H acceptors: 7 LogP: 3.74 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H]1O[C@H](Sc2ccccc2)[C@@H]([C@H]([C@@H]1O)O)NC(=O)CCCCCC1=C(C)C(=O)c2c(C1=O)c(O)ccc2
  • InChi: 1S/C29H33NO8S/c1-16-18(26(35)23-19(25(16)34)12-8-13-20(23)32)11-6-3-7-14-22(33)30-24-28(37)27(36)21(15-31)38-29(24)39-17-9-4-2-5-10-17/h2,4-5,8-10,12-13,21,24,27-29,31-32,36-37H,3,6-7,11,14-15H2,1H3,(H,30,33)/t21-,24-,27-,28-,29-/m1/s1
  • InChiKey: RZUKWCGTIQBYBZ-WQCIBWCFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB Get druggable targets OG5_174832 All targets in OG5_174832
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) Get druggable targets OG5_174832 All targets in OG5_174832
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) Get druggable targets OG5_174832 All targets in OG5_174832
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0109 0.0172 0.0934
Echinococcus multilocularis neuropeptide s receptor 0.0494 0.0869 0.2803
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0126 0.3005
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0037 0.0113
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.004 0.0034
Brugia malayi CHE-14 protein 0.009 0.0136 0.074
Plasmodium falciparum ferrodoxin reductase-like protein 0.0022 0.0014 0.0176
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0053
Brugia malayi Inositol-1 0.0042 0.005 0.0262
Echinococcus granulosus neuropeptide s receptor 0.0494 0.0869 0.4767
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0098 0.2388
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.006 0.0084 0.0449
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.005 0.1181
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0082 0.0123 0.3011
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0022 0.0092
Echinococcus granulosus expressed conserved protein 0.0196 0.0329 0.1799
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0022 0.0014 0.0176
Giardia lamblia NADH oxidase lateral transfer candidate 0.0082 0.0123 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0033 0.0169
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0012 0.0231
Entamoeba histolytica hypothetical protein 0.0117 0.0186 0.5194
Echinococcus multilocularis survival motor neuron protein 1 0.1021 0.1821 0.588
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0846 0.1505 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0215 0.0688
Loa Loa (eye worm) hypothetical protein 0.0036 0.004 0.021
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0082 0.0123 0.0382
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0237 0.0403 0.0397
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0055 0.0075 0.5667
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0035
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0098 0.2388
Echinococcus multilocularis neuropeptide receptor A26 0.0494 0.0869 0.2803
Loa Loa (eye worm) hypothetical protein 0.0209 0.0352 0.1925
Onchocerca volvulus 0.0094 0.0144 0.4062
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0082 0.0123 0.0117
Mycobacterium ulcerans hypothetical protein 0.0025 0.002 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0082 0.0123 0.3011
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0055 0.0075 0.04
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0037 0.0031
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0169
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0022 0.0014 0.0539
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0012 0.0053
Echinococcus granulosus geminin 0.0552 0.0974 0.5342
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.004 0.2559
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.1021 0.1821 1
Leishmania major cathepsin L-like protease 0.0068 0.0098 0.2388
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0051 0.0066 0.0415
Loa Loa (eye worm) programmed cell death 8 0.0022 0.0014 0.0066
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0027
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0052 0.115
Loa Loa (eye worm) ctsf protein 0.0018 0.0007 0.0027
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0055 0.0075 0.04
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0022 0.0046
Brugia malayi RNA recognition motif domain containing protein 0.0071 0.0103 0.0558
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0033 0.0169
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.0126 0.0752
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0012 0.0136
Schistosoma mansoni glutamate synthase 0.0022 0.0014 0.0077
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0098 0.2388
Trypanosoma cruzi DNA repair protein, putative 0.0035 0.0038 0.0899
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0082 0.0123 0.0382
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0037 0.0113
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0089 0.0482
Onchocerca volvulus 0.0018 0.0007 0.0143
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.004 0.0106
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0052 0.115
Echinococcus multilocularis L aminoadipate semialdehyde 0.0094 0.0144 0.0458
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0055 0.0075 0.0235
Trypanosoma cruzi NADH dehydrogenase, putative 0.0022 0.0014 0.0288
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0022 0.0055
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0601 0.1061 0.1056
Loa Loa (eye worm) hypothetical protein 0.0318 0.0549 0.301
Brugia malayi isocitrate dehydrogenase 0.0035 0.0037 0.0193
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0014 0.0343
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0014 0.0539
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0169
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0022 0.0014 0.0176
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.481 0.8677 0.8676
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0208 0.0351 0.192
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0026 0.0477
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0082 0.0123 0.305
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0012 0.0286
Loa Loa (eye worm) glutathione reductase 0.0237 0.0403 0.2205
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0037 0.076
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0014 0.0343
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0022 0.0014 0.0066
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.002 0.0038
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0008 0.0002
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0037 0.0113
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0037 0.076
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0014 0.0539
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0541 0.0952 0.0947
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0033 0.0198
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.004 0.0246
Schistosoma mansoni hypothetical protein 0.0022 0.0014 0.0077
Brugia malayi Muscleblind-like protein 0.0318 0.0549 0.301
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0022 0.0014 0.0203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0098 0.2431
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0022 0.0546
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0022 0.0383
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.009 0.0136 0.074
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.021 0.1339
Schistosoma mansoni transcription factor LCR-F1 0.0117 0.0186 0.1187
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0094 0.0144 0.078
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0052 0.0278
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0052 0.0278
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0035 0.0038 0.095
Onchocerca volvulus 0.0018 0.0007 0.0143
Brugia malayi hypothetical protein 0.0017 0.0005 0.0018
Onchocerca volvulus 0.0036 0.004 0.1092
Leishmania major DNA polymerase kappa, putative 0.0021 0.0012 0.0231
Mycobacterium leprae conserved hypothetical protein 0.0036 0.004 0.0082
Schistosoma mansoni disulfide oxidoreductase 0.0022 0.0014 0.0077
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0037 0.0113
Trypanosoma cruzi DNA repair protein, putative 0.0035 0.0038 0.0899
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0098 0.2431
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.002 0.0038
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0022 0.0014 0.0019
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.005 0.33
Echinococcus multilocularis tar DNA binding protein 0.0071 0.0103 0.0328
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0022 0.0014 0.0288
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0022 0.0014 0.0019
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0012 0.0362
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0022 0.0014 0.0039
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0022 0.0014 0.0007
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0007 0.0027
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0098
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0007 0.0027
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0022 0.0014 0.0176
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.004 0.0123
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0037 0.0917
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.004 0.2559
Schistosoma mansoni inositol monophosphatase 0.0042 0.005 0.0308
Chlamydia trachomatis thioredoxin reductase 0.0022 0.0014 0.0037
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0007 0.0032
Schistosoma mansoni glutamate synthase 0.0022 0.0014 0.0077
Treponema pallidum recombinase A 0.0115 0.0182 0.1128
Echinococcus granulosus Protein patched homolog 1 0.009 0.0136 0.074
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0074 0.0067
Echinococcus multilocularis muscleblind protein 0.0318 0.0549 0.177
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0846 0.1505 0.4683
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.002 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0033 0.0169
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0018
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0027
Echinococcus multilocularis expressed protein 0.0051 0.0066 0.0208
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0026 0.0477
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0172 0.0934
Treponema pallidum replicative DNA helicase (dnaB) 0.0846 0.1505 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0082 0.0123 0.3011
Mycobacterium tuberculosis Conserved protein 0.0036 0.004 0.0034
Leishmania major cathepsin L-like protease 0.0068 0.0098 0.2388
Schistosoma mansoni Replicative DNA helicase 0.0846 0.1505 0.9684
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0087 0.2121
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0033 0.0099
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.005 0.1181
Echinococcus multilocularis zinc finger protein 0.0023 0.0016 0.0047
Echinococcus granulosus dna polymerase kappa 0.0021 0.0012 0.0053
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0033 0.0169
Trypanosoma brucei unspecified product 0.0021 0.0012 0.0286
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0012 0.0286
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0037 0.0192
Loa Loa (eye worm) twinkle helicase 0.0242 0.0412 0.2253
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0012 0.0286
Mycobacterium leprae Conserved hypothetical protein 0.1782 0.3198 1
Schistosoma mansoni hypothetical protein 0.0208 0.0351 0.225
Trichomonas vaginalis glutamate synthase, putative 0.0022 0.0014 0.0539
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0033 0.0099
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0026 0.0585
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.0052 0.0163
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0074 0.0232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0033 0.0169
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0033 0.0198
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.0215 0.1171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0098 0.2431
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0037 0.0866
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0082 0.0123 0.078
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0022 0.0383
Loa Loa (eye worm) TAR-binding protein 0.0071 0.0103 0.0558
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.004 0.0123
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0126 0.3005
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0007 0.0114
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0022 0.0014 0.0288
Schistosoma mansoni cpg binding protein 0.0067 0.0095 0.0601
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0014 0.0539
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0018
Toxoplasma gondii hypothetical protein 0.0029 0.0027 0.0499
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0008 0.0033
Echinococcus granulosus glutamate synthase 0.0022 0.0014 0.0066
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0033 0.0198
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0055 0.0075 0.04
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0022 0.0014 0.0066
Schistosoma mansoni hypothetical protein 0.0552 0.0974 0.6262
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0007 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0002 0.0001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0238 0.0405 0.1303
Schistosoma mansoni zinc finger protein 0.0015 0.0002 0.0003
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0037 0.076
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0022 0.0014 0.0539
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0082 0.0123 0.293
Trichomonas vaginalis glutamate synthase, putative 0.0022 0.0014 0.0539
Onchocerca volvulus 0.0022 0.0014 0.0343
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0033 0.0198
Brugia malayi AMP-binding enzyme family protein 0.0025 0.002 0.0098
Echinococcus granulosus Niemann Pick C1 protein 0.0209 0.0352 0.1925
Onchocerca volvulus 0.0018 0.0007 0.0143
Echinococcus multilocularis geminin 0.0552 0.0974 0.3142
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0022 0.0014 0.0539
Loa Loa (eye worm) inositol-1 0.0042 0.005 0.0262
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.005 0.024
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0022 0.0383
Trypanosoma brucei ISWI complex protein 0.0015 0.0002 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0098 0.2431
Onchocerca volvulus 0.0025 0.002 0.0511
Mycobacterium ulcerans ferredoxin reductase 0.0022 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0033
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0846 0.1505 0.4981
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0012 0.0231
Echinococcus granulosus cathepsin l1 0.0018 0.0007 0.0027
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.002 0.0019
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0033 0.0881
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.004 0.0246
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0022 0.0014 0.0176
Mycobacterium ulcerans hypothetical protein 0.0036 0.004 0.0106
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0022 0.0014 0.0203
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.004 0.0034
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0033 0.0169
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0212 0.0358 0.2294
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.005 0.1181
Schistosoma mansoni microtubule-associated protein tau 0.0777 0.138 0.8877
Echinococcus multilocularis protein dispatched 1 0.0102 0.0159 0.0509
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0012 0.0362
Leishmania major hypothetical protein, conserved 0.0022 0.0014 0.0288
Plasmodium falciparum thioredoxin reductase 0.0082 0.0123 0.293
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0601 0.1061 0.1056
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0037 0.0193
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0022 0.0492
Trypanosoma cruzi trypanothione reductase, putative 0.0237 0.0403 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.004 0.0992
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0115 0.0182 0.1128
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.005 0.0262
Brugia malayi glutathione reductase 0.0237 0.0403 0.2205
Echinococcus granulosus L aminoadipate semialdehyde 0.0094 0.0144 0.078
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.004 0.021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0037 0.0192
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0033 0.0198
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0005 0.0023
Trypanosoma brucei NADH dehydrogenase 0.0022 0.0014 0.0343
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0022 0.0014 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0012 0.0286
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0541 0.0952 0.0947
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0169
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0007 0.0032
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0022 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0012 0.0005
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0033 0.0099
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.168 0.3013 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0022 0.0014 0.0066
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.168 0.3013 0.3009
Echinococcus multilocularis cpg binding protein 0.0067 0.0095 0.0301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0033 0.0169
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0026 0.0585
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0007 0.0143
Schistosoma mansoni hypothetical protein 0.0086 0.0131 0.083
Echinococcus granulosus zinc finger protein 0.0023 0.0016 0.008
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.002 0.0038
Echinococcus granulosus GPCR family 2 0.0035 0.0037 0.0192
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0082 0.0123 0.3011
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0037 0.0917
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0169
Schistosoma mansoni hypothetical protein 0.0021 0.0012 0.0065
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.004 0.2559
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.002 0.0038
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0082 0.0123 0.0391
Leishmania major trypanothione reductase 0.0237 0.0403 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0126 0.0682
Plasmodium vivax glutathione reductase, putative 0.0237 0.0403 1
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0033 0.0169
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0082 0.0123 0.305
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0022 0.0014 0.0039
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0022 0.0014 0.0066
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0126 0.0401
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0012 0.0053
Echinococcus granulosus dnaJ subfamily B 0.0873 0.1554 0.8531
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.002 0.0038
Mycobacterium ulcerans NADH dehydrogenase 0.0022 0.0014 0.0019
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0007 0.0027
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0008 0.0036
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0005 0.0023
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.002 0.0435
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0027 0.0086
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.002 0.0373
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0008 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0033 0.0169
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.0215 0.525
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.168 0.3013 0.9419
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0055 0.0075 0.5233
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0037 0.0866
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0022 0.0014 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0033 0.0169
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0033 0.0198
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0085 0.0459
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0027
Leishmania major DNA polymerase eta, putative 0.0021 0.0012 0.0231
Loa Loa (eye worm) hypothetical protein 0.011 0.0173 0.094
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0014 0.0288
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0022 0.0014 0.0203
Echinococcus granulosus expressed protein 0.0051 0.0066 0.0354
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0082 0.0123 0.293
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0215 0.1373
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0018
Loa Loa (eye worm) cysteine protease 0.0018 0.0007 0.0027
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.004 0.2559
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0094 0.0144 0.0914
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0035
Schistosoma mansoni hypothetical protein 0.0086 0.0131 0.083
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0007 0.0143
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0005 0.0018
Loa Loa (eye worm) hypothetical protein 0.0036 0.004 0.021
Entamoeba histolytica disulphide oxidoreductase, putative 0.0022 0.0014 0.0203
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0022 0.0014 0.0019
Onchocerca volvulus 0.0061 0.0085 0.2389
Brugia malayi CXXC zinc finger family protein 0.0061 0.0085 0.0459
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0012 0.0031
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0007 0.0114
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0082 0.0123 0.0766
Schistosoma mansoni sulfide quinone reductase 0.0022 0.0014 0.0077
Plasmodium falciparum glutathione reductase 0.0082 0.0123 0.293
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0257
Trypanosoma cruzi trypanothione reductase, putative 0.0082 0.0123 0.3011
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0012 0.0286
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.0215 0.0689
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0082 0.0123 0.3011
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0033 0.0169
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0082 0.0123 0.293
Schistosoma mansoni patched 1 0.009 0.0136 0.0867
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0055 0.0075 0.1712
Brugia malayi hypothetical protein 0.0039 0.0045 0.0236
Loa Loa (eye worm) hypothetical protein 0.009 0.0136 0.074
Loa Loa (eye worm) RNA binding protein 0.0071 0.0103 0.0558
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0037 0.0192
Loa Loa (eye worm) hypothetical protein 0.0036 0.004 0.021
Brugia malayi hypothetical protein 0.0018 0.0008 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0215 0.0688
Loa Loa (eye worm) hypothetical protein 0.0318 0.0549 0.301
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0007 0.0016
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0215 0.1373
Mycobacterium tuberculosis Probable oxidoreductase 0.0601 0.1061 0.1056
Onchocerca volvulus 0.0208 0.0351 1
Brugia malayi Bromodomain containing protein 0.0039 0.0044 0.0233
Mycobacterium tuberculosis Conserved protein 0.0036 0.004 0.0034
Schistosoma mansoni survival motor neuron protein 0.0208 0.0351 0.225
Schistosoma mansoni hypothetical protein 0.0873 0.1554 1
Brugia malayi beta-lactamase 0.0036 0.004 0.021
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0051 0.0066 0.15
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0098
Echinococcus multilocularis microtubule associated protein 2 0.0777 0.138 0.4453
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0033 0.0099
Loa Loa (eye worm) hypothetical protein 0.0035 0.0037 0.0192
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0037 0.0193
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0033 0.0099
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0082 0.0123 0.3011
Brugia malayi Bromodomain containing protein 0.0079 0.0117 0.0635
Leishmania major hypothetical protein, conserved 0.0022 0.0014 0.0288
Loa Loa (eye worm) hypothetical protein 0.0036 0.004 0.021
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0012 0.0286
Schistosoma mansoni hypothetical protein 0.0035 0.0037 0.0226
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0035
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0037 0.0866
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0012 0.0231
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0033 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0103 0.0654
Entamoeba histolytica hypothetical protein 0.0026 0.0022 0.044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0117 0.0186 0.0596
Trichomonas vaginalis mercuric reductase, putative 0.0082 0.0123 0.8958
Mycobacterium ulcerans dehydrogenase 0.0022 0.0014 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0012 0.0231
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0012 0.0005
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0022 0.0014 0.0066
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.0055 0.0075 0.0221
Toxoplasma gondii ABC1 family protein 0.0036 0.004 0.0837
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0098 0.2431
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0055 0.0075 0.1712
Brugia malayi hypothetical protein 0.0117 0.0186 0.1013
Echinococcus multilocularis cysteine protease 0.0018 0.0007 0.0016
Echinococcus granulosus microtubule associated protein 2 0.0777 0.138 0.7573
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0082 0.0123 0.305
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0037 0.0192
Leishmania major hypothetical protein, conserved 0.0028 0.0026 0.0585
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0109 0.0591
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0033 0.0169
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0027 0.004
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0209 0.0352 1
Brugia malayi Probable ClpP-like protease 0.0084 0.0126 0.0682
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0074 0.0188
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0007 0.0027
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0005 0.0018
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0005 0.0021
Toxoplasma gondii selenide, water dikinase 0.0022 0.0014 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0033 0.0169
Schistosoma mansoni cpg binding protein 0.0061 0.0085 0.0538
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0022 0.0064
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0026 0.0638
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0027 0.0499
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.002 0.0435
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0022 0.0014 0.0019
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0082 0.0123 0.3011
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.005 0.33
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0126 0.0392
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.002 0.0373
Echinococcus multilocularis muscleblind protein 1 0.0318 0.0549 0.177
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0027
Brugia malayi beta-lactamase family protein 0.0036 0.004 0.021
Mycobacterium ulcerans monoxygenase 0.0022 0.0014 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0012 0.0231
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0215 0.0688
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0033 0.0198
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0012 0.0011
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0051 0.0066 0.0354
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0012 0.0286
Brugia malayi RNA binding protein 0.0071 0.0103 0.0558
Loa Loa (eye worm) hypothetical protein 0.0036 0.004 0.021
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0022 0.0014 0.0203
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.005 0.1079
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0172 0.0934
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0014 0.0343
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.002 0.0013
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0022 0.0128
Onchocerca volvulus 0.0036 0.004 0.1092
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0055 0.0075 0.1806
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0007 0.0026
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0022 0.011
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0126 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0012 0.0286
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0055 0.0075 0.1806
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0022 0.0014 0.0288
Brugia malayi TAR-binding protein 0.0071 0.0103 0.0558
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0005 0.0018
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0115 0.0182 0.0528
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.002 0.0038
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0126 0.3005
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0055 0.0075 0.1852
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0027
Trichomonas vaginalis apoptosis inducing factor, putative 0.0022 0.0014 0.0539
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0033 0.0169
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0098 0.2431
Brugia malayi glutamate synthase 0.0022 0.0014 0.0066
Schistosoma mansoni sulfide quinone reductase 0.0022 0.0014 0.0077
Echinococcus multilocularis Niemann Pick C1 protein 0.0298 0.0514 0.1656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0098 0.2431
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0082 0.0123 0.0666
Trypanosoma cruzi NADH dehydrogenase, putative 0.0022 0.0014 0.0288
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0103 0.0654
Echinococcus granulosus sterol regulatory element binding protein 0.009 0.0136 0.074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0033 0.0169
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0126 0.0752
Mycobacterium ulcerans hypothetical protein 0.0022 0.0014 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0033 0.0169
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.004 0.0941
Brugia malayi nuclear receptor NHR-88 0.0032 0.0033 0.0169
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0033 0.0881
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0033 0.0169
Echinococcus granulosus tar DNA binding protein 0.0071 0.0103 0.0558
Entamoeba histolytica hypothetical protein 0.0117 0.0186 0.5194
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0008 0.0039
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0027 0.0499
Schistosoma mansoni hypothetical protein 0.0035 0.0037 0.0226
Echinococcus multilocularis dnaJ subfamily B 0.0873 0.1554 0.5017
Plasmodium vivax hypothetical protein, conserved 0.0036 0.004 0.0837
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0033 0.0169
Trypanosoma brucei trypanothione reductase 0.0237 0.0403 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.002 0.0098
Leishmania major NADH dehydrogenase, putative 0.0022 0.0014 0.0288
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0005 0.0021
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0082 0.0123 0.293
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0022 0.0046
Echinococcus multilocularis cysteine protease 0.0018 0.0007 0.0016
Plasmodium falciparum thioredoxin reductase 0.0237 0.0403 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0052 0.0278
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0005 0.0012
Entamoeba histolytica thioredoxin reductase, putative 0.0022 0.0014 0.0203
Mycobacterium tuberculosis Probable reductase 0.0541 0.0952 0.0947
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0098 0.2431
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1725 0.3096 1
Schistosoma mansoni bromodomain containing protein 0.0067 0.0096 0.0607
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0042 0.0088
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0051 0.0066 0.15
Echinococcus granulosus Niemann Pick C1 protein 0.0298 0.0514 0.2816
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0541 0.0952 0.0947
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.0052 0.0278
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0033 0.0169
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0022 0.0014 0.0206
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.0189 0.4593
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.004 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0098 0.2431
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.004 0.021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0033 0.0169
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.002 0.0373
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0022 0.0014 0.0039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0026 0.0131
Schistosoma mansoni glutamate synthase 0.0022 0.0014 0.0077
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0117 0.0186 0.1013
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0033 0.0099
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0022 0.0014 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0012 0.0286
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0022 0.0016
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0012 0.0031
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0022 0.0014 0.0007
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0082 0.0123 0.305
Onchocerca volvulus 0.0018 0.0007 0.0143
Loa Loa (eye worm) thioredoxin reductase 0.0237 0.0403 0.2205
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0033 0.0169
Schistosoma mansoni zinc finger protein 0.0023 0.0016 0.0094
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0126 0.3005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0008 0.002
Mycobacterium ulcerans recombinase A 0.0115 0.0182 0.0578
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0027
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0022 0.0383
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.004 0.0106
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0126 0.0786
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0014 0.0539
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0037 0.0193
Schistosoma mansoni hypothetical protein 0.0015 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0071 0.0103 0.0557
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0012 0.0053
Plasmodium vivax thioredoxin reductase, putative 0.0237 0.0403 1
Toxoplasma gondii thioredoxin reductase 0.0237 0.0403 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0144 0.078
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0014 0.0539
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0007 0.0143
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0082 0.0123 0.3011
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.005 0.1239
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0035
Giardia lamblia Thioredoxin reductase 0.0022 0.0014 0.0206
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0022 0.0014 0.0176
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0022 0.0014 0.0019
Echinococcus multilocularis glutamate synthase 0.0022 0.0014 0.0039
Entamoeba histolytica hypothetical protein 0.0117 0.0186 0.5194
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0022 0.0014 0.0019
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0089 0.0283
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0033 0.0169
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0012 0.0062
Brugia malayi hypothetical protein 0.1021 0.1821 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.004 0.0034
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0022 0.0014 0.0039
Trichomonas vaginalis esterase, putative 0.0036 0.004 0.2559
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0022 0.0014 0.0539
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0035
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0012 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0103 0.0654
Loa Loa (eye worm) hypothetical protein 0.0075 0.0109 0.0591
Brugia malayi Niemann-Pick C1 protein precursor 0.0209 0.0352 0.1925
Schistosoma mansoni inositol monophosphatase 0.0042 0.005 0.0308
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.002 0.0019
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0022 0.0014 0.0176
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0082 0.0123 0.0382
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0033 0.0169
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0098 0.2388
Echinococcus multilocularis Niemann Pick C1 protein 0.0209 0.0352 0.1132
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0012 0.0231
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0037 0.0192
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0022 0.0014 0.0539
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0051 0.0066 0.0354
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0072 0.1728
Onchocerca volvulus 0.0018 0.0007 0.0143
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0033 0.0198
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0012 0.0286
Brugia malayi nuclear hormone receptor 0.0032 0.0033 0.0169
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.004 0.0209
Echinococcus granulosus muscleblind protein 0.0318 0.0549 0.301
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0033 0.0169
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0126 0.0799
Loa Loa (eye worm) hypothetical protein 0.0022 0.0014 0.0066
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0082 0.0123 0.0732
Toxoplasma gondii TIM10 family protein, putative 0.0051 0.0066 0.15
Plasmodium falciparum glutathione reductase 0.0237 0.0403 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0033 0.0169
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.0394 0.0387
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0126 0.0786
Schistosoma mansoni coup transcription factor 0.0032 0.0033 0.0198
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0022 0.0014 0.0066
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0114
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0075 0.0068
Loa Loa (eye worm) hypothetical protein 0.0046 0.0058 0.0311
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0601 0.1061 0.329
Brugia malayi hypothetical protein 0.0017 0.0005 0.0018
Brugia malayi nuclear receptor RXR 0.0017 0.0005 0.0018
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0074 0.0067
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0022 0.0055
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0082 0.0123 0.0666
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0012 0.0286
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0114
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.0215 0.5304
Onchocerca volvulus 0.0036 0.004 0.1092
Echinococcus granulosus neuropeptide receptor A26 0.0494 0.0869 0.4767
Onchocerca volvulus 0.0018 0.0007 0.0143
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0022 0.0014 0.0343
Mycobacterium ulcerans beta-lactamase 0.0036 0.004 0.0106
Mycobacterium ulcerans glutamate synthase subunit beta 0.0022 0.0014 0.0019
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0007 0.0016
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0082 0.0123 0.293
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0082 0.0123 0.3011
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 0.0055 0.0075 0.0191
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.004 0.0034
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0012 0.0054
Loa Loa (eye worm) hypothetical protein 0.0036 0.004 0.021
Schistosoma mansoni hypothetical protein 0.0035 0.0037 0.0226
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0098
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0022 0.0014 0.0066
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0172 0.0934
Leishmania major cathepsin L-like protease 0.0068 0.0098 0.2388
Giardia lamblia Glutamate synthase 0.0022 0.0014 0.0206
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0169
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0098 0.2431
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0126 0.0392
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0022 0.0014 0.0066
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0055 0.0075 0.0469
Schistosoma mansoni DNA polymerase eta 0.0021 0.0012 0.0062
Chlamydia trachomatis replicative DNA helicase 0.0846 0.1505 1
Leishmania major hypothetical protein, conserved 0.0022 0.0014 0.0288
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0033 0.0169
Schistosoma mansoni hypothetical protein 0.0043 0.0052 0.0326
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0082 0.0123 0.0732
Echinococcus multilocularis dna polymerase eta 0.0021 0.0012 0.0031
Loa Loa (eye worm) fibroinase 0.0018 0.0007 0.0027
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0022 0.0014 0.0343
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0022 0.0014 0.0066
Echinococcus granulosus cpg binding protein 0.0067 0.0095 0.0513
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0009 0.0022
Echinococcus multilocularis GPCR, family 2 0.0035 0.0037 0.0113
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.004 0.0034
Brugia malayi hypothetical protein 0.0039 0.0045 0.0236
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0033 0.0881
Brugia malayi AMP-binding enzyme family protein 0.0025 0.002 0.0098
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0022 0.0014 0.0039
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0169
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0033 0.0169
Onchocerca volvulus 0.0018 0.0007 0.0143
Echinococcus granulosus survival motor neuron protein 1 0.1021 0.1821 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0022 0.0014 0.0066
Leishmania major hypothetical protein, conserved 0.0036 0.004 0.0941
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.004 0.0034
Loa Loa (eye worm) hypothetical protein 0.0084 0.0126 0.0682
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0022 0.0014 0.0176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0082 0.0123 0.3011
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0022 0.0014 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0033 0.0169
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.005 0.0154
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0082 0.0123 0.3011
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0022 0.0014 0.0288
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0008 0.0039
Schistosoma mansoni hypothetical protein 0.0552 0.0974 0.6262
Entamoeba histolytica hypothetical protein 0.0117 0.0186 0.5194
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0071 0.0103 0.0558
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0012 0.0286
Schistosoma mansoni hypothetical protein 0.0086 0.0131 0.083
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0009 0.0038
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0033 0.0169
Brugia malayi beta-lactamase family protein 0.0036 0.004 0.021
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0007 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0033 0.0169
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0114
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0033 0.0099
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0022 0.0014 0.0007
Schistosoma mansoni hypothetical protein 0.0117 0.0186 0.1187
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0037 0.076
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0022 0.0014 0.0203
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0027
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.004 0.2559
Schistosoma mansoni hypothetical protein 0.0035 0.0037 0.0226
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0037 0.0226
Echinococcus granulosus dna polymerase eta 0.0021 0.0012 0.0053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0037 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0012 0.0286
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0022 0.0014 0.0288
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0042 0.0035
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0012 0.0286
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.004 0.021
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0033 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0098 0.2431
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0055 0.0075 0.1965
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0103 0.0654
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.004 0.0941
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0014 0.0288
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0022 0.0014 0.0176
Echinococcus multilocularis sterol regulatory element binding protein 0.009 0.0136 0.0435
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0033 0.0169
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0051 0.0066 0.15
Mycobacterium leprae Probable lipase LipE 0.0036 0.004 0.0082
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0022 0.0014 0.0176
Trichomonas vaginalis glutathione reductase, putative 0.0082 0.0123 0.8958
Mycobacterium tuberculosis Probable dehydrogenase 0.0541 0.0952 0.0947
Brugia malayi ecdysteroid receptor 0.0032 0.0033 0.0169
Brugia malayi PHD-finger family protein 0.0029 0.0026 0.0133
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0114
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0007 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0082 0.0123 0.3011
Toxoplasma gondii NADPH-glutathione reductase 0.0082 0.0123 0.293
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0071 0.0103 0.0654
Treponema pallidum NADH oxidase 0.0082 0.0123 0.0732
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0005 0.0018
Loa Loa (eye worm) beta-lactamase 0.0036 0.004 0.021
Loa Loa (eye worm) hypothetical protein 0.0032 0.0033 0.0169
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0055 0.0075 0.1965
Schistosoma mansoni hypothetical protein 0.0075 0.0109 0.0693
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0033 0.0198
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0074 0.0395
Mycobacterium tuberculosis Conserved protein 0.0036 0.004 0.0034
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0033 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0033 0.0169
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0014 0.0288
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0026 0.0477
Onchocerca volvulus 0.0032 0.0033 0.0881
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0055 0.0075 0.1712
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0033 0.0099
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0037 0.0113
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0022 0.0014 0.0007
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0012 0.0062
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.005 0.33
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.002 0.0038
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0055 0.0075 0.1806
Plasmodium vivax ferrodoxin reductase, putative 0.0022 0.0014 0.0176
Brugia malayi steroid hormone receptor 0.0032 0.0033 0.0169
Mycobacterium ulcerans lipase LipD 0.0036 0.004 0.0106
Echinococcus granulosus thioredoxin glutathione reductase 0.0238 0.0405 0.2216
Leishmania major cathepsin L-like protease 0.0018 0.0007 0.0114
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0037 0.0113
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0033 0.0198
Brugia malayi hypothetical protein 0.0028 0.0026 0.0131
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.0215 0.0209
Loa Loa (eye worm) hypothetical protein 0.0039 0.0044 0.0233
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.005 0.0138
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.006 0.0084 0.0449
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.005 0.1231
Schistosoma mansoni hypothetical protein 0.0086 0.0131 0.083
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0022 0.0014 0.0007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0541 0.0952 0.0947
Chlamydia trachomatis recombinase RecA 0.0115 0.0182 0.1161
Echinococcus multilocularis protein patched 0.009 0.0136 0.0435
Schistosoma mansoni cpg binding protein 0.0067 0.0095 0.0601
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0012 0.0056
Echinococcus multilocularis expressed conserved protein 0.0196 0.0329 0.1058
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0009 0.0038
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0012 0.0053
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0005 0.002
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0043 0.0052 0.115
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0026 0.0477
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0541 0.0952 0.2947
Brugia malayi Thioredoxin reductase 0.0237 0.0403 0.2205
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0033 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0136 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 94.8 % Inhibition of Mycobacterium tuberculosis MshB expressed in Escherichia coli BL21 at 500 uM after 10 mins by HPLC analysis ChEMBL. 20304659
Ki (binding) = 16.8 uM Inhibition of Mycobacterium tuberculosis MshB expressed in Escherichia coli BL21 after 10 mins by HPLC analysis ChEMBL. 20304659

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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