Detailed information for compound 1159397

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 401.378 | Formula: C22H18F3NO3
  • H donors: 2 H acceptors: 4 LogP: 5.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cc(c2c(c1)c(C(=O)O)c(c(n2)C1(CC1)c1ccccc1)O)C(F)(F)F
  • InChi: 1S/C22H18F3NO3/c1-2-12-10-14-16(20(28)29)18(27)19(26-17(14)15(11-12)22(23,24)25)21(8-9-21)13-6-4-3-5-7-13/h3-7,10-11,27H,2,8-9H2,1H3,(H,28,29)
  • InChiKey: OKGIRFQYPOUVPO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis GPCR, family 2 0.0035 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0023 0.0133 0.0197
Onchocerca volvulus 0.0051 0.0452 0.3199
Onchocerca volvulus 0.0029 0.0204 0.1443
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0185 0.0477
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0734 0.1085
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0027 0.0185 0.1346
Brugia malayi hypothetical protein 0.0023 0.0137 0.0202
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0172 0.0255
Schistosoma mansoni hypothetical protein 0.0035 0.0276 0.0684
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0046
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0064 0.06 1
Schistosoma mansoni hypothetical protein 0.0076 0.0734 0.1821
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0064 0.06 0.1857
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0064 0.06 0.0978
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0058 0.0528 0.0808
Brugia malayi Isocitrate dehydrogenase 0.0014 0.0041 0.0061
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0133 0.0244
Echinococcus multilocularis lamin dm0 0.0029 0.0204 0.0204
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0064 0.06 0.1489
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0054 0.008
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0133 0.0331
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0452 0.0827
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0133 0.0943
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0502 0.105
Brugia malayi jmjC domain containing protein 0.0035 0.0268 0.0396
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.004 0.0327 0.0948
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0064 0.06 0.06
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0133 0.0197
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0408 0.4431 1
Echinococcus granulosus survival motor neuron protein 1 0.0265 0.2832 0.5182
Loa Loa (eye worm) hypothetical protein 0.0076 0.0734 0.1085
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0133 0.0197
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0133 0.0244
Echinococcus multilocularis Glycoside hydrolase, family 27 0.011 0.1108 0.1108
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0027 0.0185 0.0338
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0199 0.2103 0.4415
Echinococcus granulosus lamin dm0 0.0029 0.0204 0.0373
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0034 0.0264 0.0186
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0276 0.0504
Brugia malayi ecdysteroid receptor 0.0023 0.0133 0.0197
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0204 0.0302
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0276 0.0408
Echinococcus granulosus tumor protein p63 0.0307 0.3308 0.6053
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0064 0.06 0.0978
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0014 0.0021
Brugia malayi isocitrate dehydrogenase 0.0014 0.0041 0.0061
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0133 0.0133
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0133 0.0331
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0133 0.0197
Loa Loa (eye worm) hypothetical protein 0.0112 0.1128 0.1669
Loa Loa (eye worm) hypothetical protein 0.0023 0.0133 0.0197
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0021
Schistosoma mansoni hypothetical protein 0.0035 0.0276 0.0684
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0027 0.0185 0.2003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0187 0.0276
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0284 0.305 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0034 0.0264 0.0507
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0058 0.0528 0.1109
Plasmodium vivax ornithine aminotransferase, putative 0.0058 0.0528 0.6794
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0034 0.0264 0.074
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0185 0.0477
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0265 0.2832 0.4189
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0079 0.0757 0.1632
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0033 0.0246 0.045
Brugia malayi hypothetical protein 0.0012 0.0014 0.0021
Brugia malayi Bromodomain containing protein 0.0027 0.0187 0.0276
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.004 0.0327 0.0948
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0187 0.1366
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0133 0.0244
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0133 0.0244
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0034 0.0264 0.0507
Plasmodium falciparum thioredoxin reductase 0.0027 0.0185 0.2003
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0034 0.0264 0.0507
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0034 0.0264 0.0507
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0179 0.188 0.3879
Schistosoma mansoni hypothetical protein 0.0027 0.0187 0.0464
Leishmania major cytochrome p450-like protein 0.0034 0.0264 0.074
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0014 0.0041 0.0041
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0058 0.0523 0.0797
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0134 0.1381 0.4452
Brugia malayi mbt repeat family protein 0.0051 0.0452 0.0669
Toxoplasma gondii histone lysine methyltransferase SET1 0.0049 0.0433 0.3673
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0502 0.0743
Brugia malayi CXXC zinc finger family protein 0.0026 0.0172 0.0255
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0034 0.0264 0.0186
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.011 0.1108 0.2026
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0185 0.0477
Echinococcus multilocularis 0.0034 0.0264 0.0264
Plasmodium falciparum glutathione reductase 0.0027 0.0185 0.2003
Schistosoma mansoni hypothetical protein 0.0054 0.0483 0.1198
Leishmania major cytochrome p450-like protein 0.0034 0.0264 0.074
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0408 0.4431 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.1108 0.2748
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0058 0.0528 0.1109
Echinococcus granulosus thioredoxin glutathione reductase 0.0079 0.0763 0.1396
Echinococcus multilocularis lysine specific demethylase 5A 0.0033 0.0251 0.0251
Echinococcus multilocularis dnaJ subfamily B 0.0372 0.403 0.403
Loa Loa (eye worm) cytochrome P450 family protein 0.0136 0.1393 0.206
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0276 0.0276
Echinococcus granulosus neuropeptide s receptor 0.0501 0.5465 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0034 0.0264 0.0186
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0133 0.0133
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0027 0.0185 0.2003
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0058 0.0528 0.0634
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0064 0.06 0.1857
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.1128 0.1669
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0179 0.188 0.419
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0133 0.0197
Loa Loa (eye worm) hypothetical protein 0.0023 0.0133 0.0197
Onchocerca volvulus 0.0054 0.0483 0.3416
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0058 0.0528 0.0634
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0284 0.305 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0034 0.0264 0.0507
Echinococcus multilocularis jumonji domain containing protein 0.0038 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0021
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0133 0.0331
Loa Loa (eye worm) hypothetical protein 0.0064 0.06 0.0887
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0502 0.0747
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0284 0.305 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0133 0.0197
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0185 0.0477
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0034 0.0264 0.0507
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0408 0.4431 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0053 0.0132
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.2132 0.3901
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0014 0.0035
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0073 0.0699 0.1734
Brugia malayi hypothetical protein 0.0265 0.2832 0.4189
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0034 0.0264 0.0507
Mycobacterium ulcerans acetylornithine aminotransferase 0.0058 0.0528 0.0808
Trypanosoma brucei trypanothione reductase 0.0079 0.0757 0.2381
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0034 0.0264 0.0507
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0452 0.3199
Schistosoma mansoni transcription factor LCR-F1 0.0033 0.0246 0.061
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0185 0.0477
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0133 0.0244
Onchocerca volvulus 0.0023 0.0133 0.0943
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.129 0.1908
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0027 0.0185 0.2003
Loa Loa (eye worm) hypothetical protein 0.0137 0.1414 0.2091
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0133 0.0197
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.0046
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0027 0.0185 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.06 0.0978
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0187 0.2033
Schistosoma mansoni cytochrome P450 0.0034 0.0264 0.0655
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0034 0.0264 0.0507
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0014 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0133 0.0197
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.2132 0.2132
Brugia malayi nuclear receptor RXR 0.0012 0.0014 0.0021
Toxoplasma gondii thioredoxin reductase 0.0079 0.0757 0.6717
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0133 0.0331
Schistosoma mansoni coup transcription factor 0.0023 0.0133 0.0331
Brugia malayi cytochrome P450 0.0034 0.0264 0.039
Echinococcus multilocularis muscleblind protein 1 0.016 0.167 0.167
Mycobacterium tuberculosis Probable oxidoreductase 0.0199 0.2103 0.4698
Loa Loa (eye worm) hypothetical protein 0.0047 0.0405 0.06
Schistosoma mansoni lamin 0.0029 0.0204 0.0506
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0264 0.074
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0034 0.0264 0.0186
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.004 0.0327 0.0948
Echinococcus multilocularis ornithine aminotransferase 0.0058 0.0528 0.0528
Toxoplasma gondii hypothetical protein 0.0046 0.0392 0.329
Mycobacterium ulcerans hypothetical protein 0.0408 0.4431 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0133 0.0331
Brugia malayi MH2 domain containing protein 0.0126 0.129 0.1908
Echinococcus granulosus jumonji domain containing protein 0.0038 0.0307 0.0561
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0027 0.0187 0.0464
Loa Loa (eye worm) hypothetical protein 0.016 0.167 0.247
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0058 0.0528 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0064 0.06 0.06
Mycobacterium tuberculosis Conserved hypothetical protein 0.015 0.155 0.3437
Onchocerca volvulus 0.0045 0.0383 0.2707
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.1108 0.2748
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0133 0.0133
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.0137 0.0317
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0133 0.0331
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0058 0.0528 0.4564
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0185 0.0477
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0133 0.0197
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0014 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0034 0.0264 0.0507
Mycobacterium tuberculosis Probable aminotransferase 0.0408 0.4431 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.1128 0.1669
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0133 0.0331
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0064 0.06 0.1098
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0513 0.0758
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0034 0.0264 0.0507
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0021
Leishmania major trypanothione reductase 0.0079 0.0757 0.2381
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0064 0.06 0.1857
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0452 0.1122
Onchocerca volvulus Alhambra homolog 0.0027 0.0187 0.1322
Echinococcus granulosus dnaJ subfamily B 0.0372 0.403 0.7373
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0133 0.0197
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0058 0.0528 0.0808
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0064 0.06 0.1489
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0033 0.0246 0.0246
Loa Loa (eye worm) MBCTL1 0.0058 0.0531 0.0786
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0502 0.0747
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0027 0.0185 0.0185
Leishmania major hypothetical protein, conserved 0.0023 0.0137 0.0317
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0034 0.0264 0.0186
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.011 0.1108 0.1108
Brugia malayi jmjC domain containing protein 0.009 0.0883 0.1306
Loa Loa (eye worm) hypothetical protein 0.0023 0.0133 0.0197
Brugia malayi follicle stimulating hormone receptor 0.0617 0.6761 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0027 0.0185 0.0477
Brugia malayi Thioredoxin reductase 0.0079 0.0757 0.112
Brugia malayi nuclear hormone receptor 0.0023 0.0133 0.0197
Plasmodium vivax glutathione reductase, putative 0.0079 0.0757 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0185 0.0477
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0185 0.0477
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0199 0.2103 0.4698
Schistosoma mansoni hypothetical protein 0.0372 0.403 1
Loa Loa (eye worm) glutathione reductase 0.0079 0.0757 0.112
Brugia malayi Cytochrome P450 family protein 0.0136 0.1393 0.206
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0034 0.0264 0.0507
Leishmania major mitochondrial DNA polymerase beta 0.0284 0.305 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0014 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0133 0.0197
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0523 0.0774
Trypanosoma cruzi trypanothione reductase, putative 0.0079 0.0757 0.2381
Echinococcus multilocularis neuropeptide receptor A26 0.0501 0.5465 0.5465
Echinococcus multilocularis isocitrate dehydrogenase 0.0014 0.0041 0.0041
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0199 0.2103 0.4698
Treponema pallidum NADH oxidase 0.0027 0.0185 0.5
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0531 0.0972
Schistosoma mansoni hypothetical protein 0.0035 0.0276 0.0684
Schistosoma mansoni hypothetical protein 0.0033 0.0246 0.061
Echinococcus granulosus cytochrome P450 2K1 0.0034 0.0264 0.0483
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0276 0.0408
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0137 0.0317
Mycobacterium tuberculosis Probable dehydrogenase 0.0179 0.188 0.419
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0041 0.0041
Plasmodium falciparum phd finger protein, putative 0.0027 0.0187 0.2033
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0133 0.0331
Echinococcus multilocularis musashi 0.0029 0.0204 0.0204
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0014 0.0041 0.0076
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0027 0.0185 0.2003
Echinococcus multilocularis PHD finger protein rhinoceros 0.0027 0.0187 0.0187
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0133 0.0244
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0027 0.0185 0.0477
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0021
Brugia malayi PHD-finger family protein 0.0027 0.0187 0.0276
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0034 0.0264 0.074
Echinococcus granulosus cpg binding protein 0.0028 0.0189 0.0346
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0014 0.0041 0.0102
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0034 0.0264 0.0507
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0134 0.1381 0.4452
Echinococcus granulosus intermediate filament protein 0.0029 0.0204 0.0373
Schistosoma mansoni hypothetical protein 0.0182 0.191 0.474
Echinococcus granulosus PHD finger protein rhinoceros 0.0027 0.0187 0.0342
Brugia malayi glutathione reductase 0.0079 0.0757 0.112
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0531 0.0786
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0058 0.0528 0.0634
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0137 0.1332
Loa Loa (eye worm) hypothetical protein 0.0023 0.0133 0.0197
Loa Loa (eye worm) hypothetical protein 0.0045 0.0383 0.0566
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0452 0.0452
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0058 0.0528 0.1109
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0073 0.0699 0.1211
Mycobacterium ulcerans hypothetical protein 0.015 0.155 0.3215
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0034 0.0264 0.0186
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0133 0.0197
Echinococcus multilocularis lamin 0.0029 0.0204 0.0204
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0034 0.0264 0.0186
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0133 0.0331
Echinococcus multilocularis ornithine aminotransferase 0.0058 0.0528 0.0528
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0133 0.0331
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0041 0.0041
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0531 0.0972
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0133 0.0197
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0204 0.0302
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0034 0.0264 0.0186
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0034 0.0264 0.0186
Brugia malayi Melibiase family protein 0.0073 0.0699 0.1034
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0187 0.1366
Echinococcus multilocularis thioredoxin glutathione reductase 0.0079 0.0763 0.0763
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0133 0.0197
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0073 0.0699 0.1034
Plasmodium vivax thioredoxin reductase, putative 0.0079 0.0757 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0133 0.0197
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0531 0.0531
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0502 0.1246
Trypanosoma brucei DNA polymerase beta thumb, putative 0.004 0.0327 0.0948
Echinococcus granulosus lamin 0.0029 0.0204 0.0373
Plasmodium falciparum thioredoxin reductase 0.0079 0.0757 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0185 0.0477
Schistosoma mansoni hypothetical protein 0.0311 0.3353 0.8321
Echinococcus multilocularis geminin 0.0182 0.191 0.191
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0034 0.0264 0.0186
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0034 0.0264 0.0186
Echinococcus granulosus peregrin 0.0027 0.0187 0.0342
Loa Loa (eye worm) hypothetical protein 0.0035 0.0276 0.0408
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0034 0.0264 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0133 0.0197
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0179 0.188 0.419
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.009 0.0883 0.0883
Toxoplasma gondii NADPH-glutathione reductase 0.0027 0.0185 0.1346
Loa Loa (eye worm) PHD-finger family protein 0.0027 0.0187 0.0276
Brugia malayi intermediate filament protein 0.0029 0.0204 0.0302
Brugia malayi hypothetical protein 0.0137 0.1414 0.2091
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0133 0.0244
Brugia malayi Muscleblind-like protein 0.016 0.167 0.247
Plasmodium falciparum ornithine aminotransferase 0.0058 0.0528 0.6794
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0034 0.0264 0.0507
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0034 0.0264 0.0186
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0133 0.0133
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0133 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0133 0.0197
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0276 0.0408
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0204 0.0302
Brugia malayi nuclear receptor NHR-88 0.0023 0.0133 0.0197
Leishmania major cytochrome p450-like protein 0.0058 0.0523 0.1601
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0027 0.0185 0.0477
Echinococcus multilocularis Aminotransferase class III 0.0058 0.0528 0.0528
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0185 0.0477
Echinococcus granulosus muscleblind protein 0.016 0.167 0.3055
Brugia malayi Cytochrome P450 family protein 0.0058 0.0523 0.0774
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0133 0.0197
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0055 0.0499 0.1238
Giardia lamblia PHD finger protein 15 0.0027 0.0187 0.0052
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0424 0.1272
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0133 0.0197
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0133 0.0943
Brugia malayi Cytochrome P450 family protein 0.0058 0.0523 0.0774
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0058 0.0528 0.0808
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.1128 0.1669
Echinococcus multilocularis tumor protein p63 0.0307 0.3308 0.3308
Schistosoma mansoni lamin 0.0029 0.0204 0.0506
Echinococcus multilocularis survival motor neuron protein 1 0.0265 0.2832 0.2832
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0137 0.1332
Loa Loa (eye worm) hypothetical protein 0.0023 0.0133 0.0197
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0058 0.0528 1
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0133 0.0197
Loa Loa (eye worm) cytochrome P450 0.0034 0.0264 0.039
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.129 0.1908
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0268 0.0396
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0064 0.06 0.1857
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0133 0.0133
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0134 0.1381 0.4452
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0064 0.06 0.1098
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0452 0.0452
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0133 0.0943
Toxoplasma gondii Alpha-galactosidase 0.0016 0.0055 0.0125
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0452 0.1122
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0276 0.0504
Echinococcus granulosus Aminotransferase class III 0.0058 0.0528 0.0966
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0034 0.0264 0.0186
Toxoplasma gondii cytochrome p450 superfamily protein 0.0034 0.0264 0.2088
Echinococcus multilocularis peregrin 0.0027 0.0187 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0133 0.0197
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0058 0.0528 0.131
Brugia malayi hypothetical protein 0.0012 0.0014 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0034 0.0264 0.0507
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0523 0.0774
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0133 0.0244
Schistosoma mansoni survival motor neuron protein 0.0054 0.0483 0.1198
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.002 0.0104 0.0154
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.009 0.0883 0.1615
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0179 0.188 0.419
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0034 0.0264 0.0186
Schistosoma mansoni hypothetical protein 0.0034 0.0264 0.0655
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0452 0.0669
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0133 0.0197
Plasmodium vivax ataxin-2 like protein, putative 0.0023 0.0137 0.1332
Loa Loa (eye worm) hypothetical protein 0.0028 0.0198 0.0293
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0034 0.0264 0.0186
Schistosoma mansoni intermediate filament proteins 0.0029 0.0204 0.0506
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0034 0.0264 0.0186
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0014 0.0014
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0268 0.0665
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0523 0.1601
Trypanosoma brucei cytochrome P450, putative 0.0058 0.0523 0.1601
Mycobacterium ulcerans L-lysine aminotransferase 0.0058 0.0528 0.0808
Trypanosoma cruzi cytochrome P450, putative 0.0058 0.0523 0.1601
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0185 0.0477
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0185 0.0477
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0058 0.0528 0.0808
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0064 0.06 0.0887
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0408 0.4431 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0034 0.0264 0.0186
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0034 0.0264 0.0507
Echinococcus multilocularis ubiquitin specific protease 41 0.0064 0.06 0.06
Loa Loa (eye worm) hypothetical protein 0.0051 0.0452 0.0669
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0133 0.0197
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0034 0.0264 0.0507
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0054 0.008
Echinococcus multilocularis cpg binding protein 0.0028 0.0189 0.0189
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0133 0.0244
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0133 0.0197
Brugia malayi hypothetical protein 0.0015 0.0046 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0133 0.0197
Loa Loa (eye worm) thioredoxin reductase 0.0079 0.0757 0.112
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0034 0.0264 0.074
Loa Loa (eye worm) CYP4Cod1 0.0058 0.0523 0.0774
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0073 0.0699 0.1734
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0027 0.0185 0.0458
Brugia malayi steroid hormone receptor 0.0023 0.0133 0.0197
Brugia malayi hypothetical protein 0.0033 0.0246 0.0364
Loa Loa (eye worm) hypothetical protein 0.016 0.167 0.247
Echinococcus granulosus GPCR family 2 0.0035 0.0276 0.0504
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0034 0.0264 0.0507
Schistosoma mansoni hypothetical protein 0.0182 0.191 0.474
Loa Loa (eye worm) hypothetical protein 0.0023 0.0137 0.0202
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.007 0.0103
Onchocerca volvulus 0.0029 0.0204 0.1443
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0452 0.0827
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0016 0.0055 0.0136
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0037 0.0067
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0034 0.0264 0.0507
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0133 0.0331
Plasmodium falciparum glutathione reductase 0.0079 0.0757 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0617 0.6761 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0185 0.0477
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.1108 0.2748
Echinococcus granulosus neuropeptide receptor A26 0.0501 0.5465 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0137 0.0317
Loa Loa (eye worm) hypothetical protein 0.0058 0.0531 0.0786
Onchocerca volvulus 0.0137 0.1414 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0034 0.0264 0.0186
Echinococcus granulosus ubiquitin specific protease 41 0.0064 0.06 0.1098
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0027 0.0185 0.0477
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0034 0.0264 0.0507
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0055
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0133 0.0133
Echinococcus multilocularis neuropeptide s receptor 0.0501 0.5465 0.5465
Schistosoma mansoni hypothetical protein 0.0035 0.0276 0.0684
Loa Loa (eye worm) isocitrate dehydrogenase 0.0014 0.0041 0.0061
Echinococcus granulosus ornithine aminotransferase 0.0058 0.0528 0.0966
Toxoplasma gondii melibiase subfamily protein 0.011 0.1108 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0041 0.0041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0133 0.0331
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0133 0.0133
Schistosoma mansoni cpg binding protein 0.0026 0.0172 0.0428
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0452 0.1122
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0064 0.06 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0502 0.1532
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0058 0.0528 0.0781
Schistosoma mansoni cpg binding protein 0.0028 0.0189 0.0469
Toxoplasma gondii LsmAD domain-containing protein 0.0023 0.0137 0.0895
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0049 0.0424 0.0627
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0531 0.1318
Brugia malayi mbt repeat family protein 0.0051 0.0452 0.0669
Mycobacterium tuberculosis Probable reductase 0.0179 0.188 0.419
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0179 0.188 0.419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0133 0.0197
Loa Loa (eye worm) hypothetical protein 0.0023 0.0133 0.0197
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.011 0.1108 0.2748
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0268 0.0665
Schistosoma mansoni cellular tumor antigen P53 0.0045 0.0383 0.095
Onchocerca volvulus 0.0026 0.0172 0.1219
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0483 0.0714
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0268 0.049
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0021
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.002 0.0104 0.0154
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0058 0.0528 0.1109
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0502 0.0919
Loa Loa (eye worm) hypothetical protein 0.0029 0.0204 0.0302
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0037 0.0037
Schistosoma mansoni cpg binding protein 0.0028 0.0189 0.0469
Brugia malayi Cytochrome P450 family protein 0.0034 0.0264 0.039
Echinococcus granulosus geminin 0.0182 0.191 0.3495
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0014 0.0026
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0034 0.0264 0.074
Echinococcus multilocularis muscleblind protein 0.016 0.167 0.167
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0034 0.0264 0.0186
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0677 0.168
Loa Loa (eye worm) hypothetical protein 0.0023 0.014 0.0207
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0027 0.0185 0.0327
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0502 0.0502

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 40 % Inhibition of recombinant PSGL-1 at 250 uM by surface plasmon resonance assay ChEMBL. 20718494
Inhibition (ADMET) = 86 % Inhibition of CYP2C9 at 3 uM ChEMBL. 20718494

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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