Detailed information for compound 1197272

Basic information

Technical information
  • TDR Targets ID: 1197272
  • Name: ZINC00159598
  • MW: 290.341 | Formula: C13H14N4O2S
  • H donors: 2 H acceptors: 2 LogP: 2.37 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c[nH]nc1N=C(Nc1ccccc1)S
  • InChi: 1S/C13H14N4O2S/c1-2-19-12(18)10-8-14-17-11(10)16-13(20)15-9-6-4-3-5-7-9/h3-8H,2H2,1H3,(H3,14,15,16,17,20)
  • InChiKey: IROYJAHBNONSDB-UHFFFAOYSA-N  


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Synonyms

  • MLS000858931
  • SMR000459010
  • ethyl 5-[(anilinocarbothioyl)amino]-1H-pyrazole-4-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1382 0.2575 1
Schistosoma mansoni kinesin eg-5 0.0178 0.0301 0.1339
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0022 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0072 0.01 0.0433
Schistosoma mansoni hypothetical protein 0.007 0.0096 0.0416
Schistosoma mansoni coup transcription factor 0.0031 0.0022 0.0083
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0153 0.0253 0.3027
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0052 0.1916
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0153 0.0253 0.1121
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0058 0.2146
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0052 0.0185
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0075 0.0275
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.1232 0.1229
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0026 0.0084
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0088 0.0084
Trypanosoma brucei polo-like protein kinase 0.0092 0.0138 0.5385
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0052 0.0185
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0138 0.5385
Loa Loa (eye worm) hypothetical protein 0.0047 0.0052 0.0626
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0022 0.0083
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0266
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0075 0.028
Trypanosoma brucei hypothetical protein, conserved 0.0153 0.0253 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0022 0.0266
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0046 0.1672
Echinococcus granulosus kinesin family 1 0.1373 0.2559 1
Plasmodium falciparum importin beta, putative 0.0033 0.0026 0.0706
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0058 0.0054
Brugia malayi Kinesin motor domain containing protein 0.0178 0.0301 0.3569
Onchocerca volvulus 0.0153 0.0253 1
Brugia malayi hypothetical protein 0.0112 0.0175 0.2053
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0046 0.0554
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0006 0.0073
Brugia malayi hypothetical protein 0.0461 0.0834 1
Echinococcus multilocularis geminin 0.0171 0.0286 0.0282
Schistosoma mansoni hypothetical protein 0.0171 0.0286 0.1272
Schistosoma mansoni tar DNA-binding protein 0.0072 0.01 0.0433
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0022 0.0083
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0058 0.1796
Loa Loa (eye worm) hypothetical protein 0.0461 0.0834 1
Loa Loa (eye worm) hypothetical protein 0.0151 0.025 0.2993
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0242 0.1073
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0022 0.0083
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.003 0.0098
Plasmodium vivax hypothetical protein, conserved 0.0153 0.0253 0.837
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0052 0.1296
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0138 0.5385
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0046 0.1672
Mycobacterium tuberculosis Conserved protein 0.0153 0.0253 0.0964
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.001 0.0006
Brugia malayi Muscleblind-like protein 0.0145 0.0238 0.2815
Entamoeba histolytica hypothetical protein 0.0112 0.0175 0.4649
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0052 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.0253 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0088 0.0328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0022 0.0266
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0046 0.0166
Brugia malayi Latrophilin receptor protein 2 0.007 0.0096 0.1101
Loa Loa (eye worm) hypothetical protein 0.0066 0.0088 0.105
Brugia malayi Importin beta-1 subunit 0.0033 0.0026 0.0252
Brugia malayi PHD-finger family protein 0.0027 0.0015 0.0122
Loa Loa (eye worm) hypothetical protein 0.0153 0.0253 0.3027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0022 0.021
Mycobacterium ulcerans esterase/lipase LipP 0.0153 0.0253 0.0964
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0052 0.0185
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0052 0.1916
Mycobacterium ulcerans TetR family transcriptional regulator 0.1382 0.2575 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.007 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0358
Echinococcus multilocularis Niemann Pick C1 protein 0.0216 0.0371 0.0367
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0052 0.0185
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0026 0.0084
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0046 0.1131
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0022 0.0018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0075 0.2847
Loa Loa (eye worm) hypothetical protein 0.0047 0.0052 0.0626
Brugia malayi Niemann-Pick C1 protein precursor 0.0216 0.0371 0.4416
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0022 0.021
Plasmodium falciparum kinesin-5 0.0178 0.0301 1
Trypanosoma brucei protein kinase, putative 0.005 0.0058 0.2146
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0014 0.0371
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0336 0.0332
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0038 0.0034
Mycobacterium ulcerans putative regulatory protein 0.0044 0.0047 0.0163
Echinococcus granulosus tumor protein p63 0.0705 0.1297 0.5061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0022 0.0266
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0219 0.0377 0.1684
Toxoplasma gondii ABC1 family protein 0.0153 0.0253 0.837
Loa Loa (eye worm) MBCTL1 0.0066 0.0088 0.105
Loa Loa (eye worm) hypothetical protein 0.0145 0.0238 0.2857
Trypanosoma cruzi hypothetical protein, conserved 0.0153 0.0253 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.0242 0.0932
Loa Loa (eye worm) hypothetical protein 0.0153 0.0253 0.3027
Schistosoma mansoni survival motor neuron protein 0.0094 0.0141 0.0619
Schistosoma mansoni ap endonuclease 0.0022 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0266
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.003 0.0847
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0022 0.0083
Mycobacterium ulcerans hypothetical protein 0.0153 0.0253 0.0964
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0022 0.021
Onchocerca volvulus 0.0153 0.0253 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.007 0.0096 0.1101
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0022 0.021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0022 0.021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0022 0.0072
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0022 0.0018
Entamoeba histolytica kinesin, putative 0.0178 0.0301 0.8082
Schistosoma mansoni hypothetical protein 0.007 0.0096 0.0416
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1382 0.2575 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0088 0.0084
Echinococcus granulosus sterol regulatory element binding protein 0.0093 0.0139 0.0527
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0022 0.0266
Giardia lamblia Kinesin-5 0.0178 0.0301 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0177 0.2118
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0022 0.0072
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0266
Loa Loa (eye worm) hypothetical protein 0.0145 0.0238 0.2857
Brugia malayi RNA binding protein 0.0072 0.01 0.1146
Brugia malayi Bromodomain containing protein 0.0082 0.0118 0.1362
Trichomonas vaginalis esterase, putative 0.0153 0.0253 1
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0058 0.0211
Brugia malayi PAS domain containing protein 0.0059 0.0076 0.0856
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0022 0.021
Loa Loa (eye worm) hypothetical protein 0.0112 0.0176 0.2106
Onchocerca volvulus 0.0103 0.0159 0.5932
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0073 0.0069
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0022 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0046 0.1672
Loa Loa (eye worm) hypothetical protein 0.007 0.0096 0.1152
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0058 0.2146
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0052 0.0185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0242 0.1073
Loa Loa (eye worm) hypothetical protein 0.0113 0.0178 0.2132
Echinococcus granulosus Niemann Pick C1 protein 0.0308 0.0546 0.2121
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0058 0.2146
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.0253 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0046 0.1672
Loa Loa (eye worm) hypothetical protein 0.0058 0.0073 0.087
Echinococcus granulosus tar DNA binding protein 0.0072 0.01 0.0376
Schistosoma mansoni kinase 0.0047 0.0053 0.022
Mycobacterium ulcerans hypothetical protein 0.0047 0.0052 0.0185
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0153 0.0253 0.0964
Echinococcus multilocularis tar DNA binding protein 0.0072 0.01 0.0096
Onchocerca volvulus 0.0114 0.0179 0.6796
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0005 0.0057
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0088 0.0328
Plasmodium vivax importin-beta 2, putative 0.0033 0.0026 0.0706
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0046 0.1672
Loa Loa (eye worm) hypothetical protein 0.0046 0.0051 0.0615
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0221 0.0382 0.4548
Entamoeba histolytica hypothetical protein 0.0112 0.0175 0.4649
Loa Loa (eye worm) beta-lactamase 0.0153 0.0253 0.3027
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.003 0.0847
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0088 0.0378
Schistosoma mansoni hypothetical protein 0.1195 0.2222 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.0336 0.3987
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0058 0.0054
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0058 0.2146
Entamoeba histolytica Ran family GTPase 0.0024 0.0009 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0138 0.0606
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.0242 0.0238
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0075 0.0275
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0022 0.0266
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0073 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0138 0.5385
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0138 0.5036
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0022 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0139 0.5398
Onchocerca volvulus 0.0044 0.0048 0.1103
Onchocerca volvulus 0.0153 0.0253 1
Echinococcus granulosus GPCR family 2 0.007 0.0096 0.0361
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0075 0.0071
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0073 0.031
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.003 0.0098
Schistosoma mansoni hypothetical protein 0.007 0.0096 0.0416
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.01 0.1146
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0073 0.087
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0009 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0138 0.5385
Trichomonas vaginalis penicillin-binding protein, putative 0.0153 0.0253 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0022 0.0018
Schistosoma mansoni hypothetical protein 0.035 0.0626 0.2803
Entamoeba histolytica hypothetical protein 0.0112 0.0175 0.4649
Mycobacterium ulcerans lipase LipD 0.0153 0.0253 0.0964
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.0336 0.0332
Mycobacterium ulcerans beta-lactamase 0.0153 0.0253 0.0964
Onchocerca volvulus 0.0058 0.0073 0.2186
Brugia malayi beta-lactamase 0.0153 0.0253 0.2987
Brugia malayi steroid hormone receptor 0.0031 0.0022 0.021
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0138 0.5385
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0022 0.0266
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0138 0.5385
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0005 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.0253 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0009 0.0055
Schistosoma mansoni tar DNA-binding protein 0.0072 0.01 0.0433
Mycobacterium tuberculosis Probable hydrolase 0.0153 0.0253 0.0964
Echinococcus multilocularis survival motor neuron protein 1 0.0461 0.0834 0.0831
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0976 0.1809 0.7021
Brugia malayi beta-lactamase family protein 0.0153 0.0253 0.2987
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0022 0.021
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0022 0.021
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0022 0.021
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0175 0.0171
Echinococcus multilocularis expressed conserved protein 0.0202 0.0346 0.0343
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0005 0.5
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0153 0.0253 0.0964
Echinococcus multilocularis snurportin 1 0.035 0.0626 0.0622
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0358
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0022 0.0083
Loa Loa (eye worm) hypothetical protein 0.0077 0.0109 0.1306
Echinococcus granulosus muscleblind protein 0.0145 0.0238 0.0918
Schistosoma mansoni hypothetical protein 0.0089 0.0132 0.0579
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0046 0.1672
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0052 0.0185
Schistosoma mansoni hypothetical protein 0.0089 0.0132 0.0579
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0052 0.0572
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0075 0.0322
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.007 0.0096 0.0361
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.0336 0.4022
Echinococcus granulosus aryl hydrocarbon receptor 0.0128 0.0206 0.079
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.035 0.0626 0.7497
Loa Loa (eye worm) hypothetical protein 0.0153 0.0253 0.3027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0147 0.0242 0.0238
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0075 0.2383
Trypanosoma brucei glucosidase, putative 0.0044 0.0046 0.1672
Trichomonas vaginalis D-aminoacylase, putative 0.0153 0.0253 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0153 0.0253 0.1121
Echinococcus granulosus Niemann Pick C1 protein 0.0216 0.0371 0.1437
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0153 0.0253 0.2987
Mycobacterium tuberculosis Probable lipase LipE 0.0153 0.0253 0.0964
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0026 0.0084
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0058 0.1796
Echinococcus multilocularis muscleblind protein 0.0145 0.0238 0.0235
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0022 0.0072
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0026 0.0022
Schistosoma mansoni aryl hydrocarbon receptor 0.0172 0.0289 0.1284
Loa Loa (eye worm) hypothetical protein 0.0216 0.0371 0.4448
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.1232 0.5539
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0052 0.0185
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0138 0.5385
Schistosoma mansoni ran 0.0024 0.0009 0.0024
Loa Loa (eye worm) hypothetical protein 0.0153 0.0253 0.3027
Schistosoma mansoni hypothetical protein 0.0094 0.0141 0.0619
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0073 0.0269
Loa Loa (eye worm) kinesin-like protein KLP2 0.0178 0.0301 0.3606
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0046 0.0042
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0046 0.1672
Brugia malayi MAP kinase sur-1 0.005 0.0058 0.0641
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0147 0.0242 0.29
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0046 0.1672
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0022 0.021
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0072 0.01 0.0433
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0266
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0238 0.0235
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0052 0.1296
Schistosoma mansoni single-minded 0.0059 0.0076 0.0324
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0052 0.1296
Loa Loa (eye worm) hypothetical protein 0.0153 0.0253 0.3027
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.0336 0.1298
Leishmania major hypothetical protein, conserved 0.0153 0.0253 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0046 0.0499
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0075 0.0275
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0075 0.0275
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0022 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0051 0.1846
Schistosoma mansoni hypothetical protein 0.0089 0.0132 0.0579
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0051 0.1846
Echinococcus multilocularis protein patched 0.0093 0.0139 0.0135
Schistosoma mansoni hypothetical protein 0.0089 0.0132 0.0579
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0005 0.5
Schistosoma mansoni tar DNA-binding protein 0.0072 0.01 0.0433
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0073 0.2186
Loa Loa (eye worm) RNA binding protein 0.0072 0.01 0.1197
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0046 0.1672
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0058 0.2146
Loa Loa (eye worm) hypothetical protein 0.0093 0.0139 0.166
Entamoeba histolytica hypothetical protein 0.0027 0.0014 0.0251
Echinococcus multilocularis beta LACTamase domain containing family member 0.0153 0.0253 0.0249
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0022 0.0072
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0014 0.0371
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0138 0.1657
Mycobacterium tuberculosis Probable lipase LipD 0.0153 0.0253 0.0964
Schistosoma mansoni importin beta-1 0.0033 0.0026 0.0098
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0073 0.031
Trichomonas vaginalis ran, putative 0.0024 0.0009 0.0183
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0046 0.1399
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0022 0.0083
Onchocerca volvulus 0.0128 0.0205 0.7928
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0147 0.0242 0.0932
Echinococcus multilocularis transfer RNA-Lys 0.0044 0.0047 0.0043
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0058 0.2146
Brugia malayi TAR-binding protein 0.0072 0.01 0.1146
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0138 0.1608
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0358
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0266
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0058 0.0211
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0058 0.2146
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0147 0.0242 0.2859
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1382 0.2575 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.0253 0.3027
Schistosoma mansoni ran 0.0024 0.0009 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0358
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0022 0.0072
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0009 0.0183
Brugia malayi Calcitonin receptor-like protein seb-1 0.0221 0.0382 0.4548
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0022 0.0018
Giardia lamblia Kinase, PLK 0.0092 0.0138 0.4507
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0138 0.3643
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0022 0.0072
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0075 0.0322
Echinococcus granulosus microtubule associated protein 2 0.0671 0.1232 0.4808
Schistosoma mansoni alpha glucosidase 0.0044 0.0046 0.0191
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0112 0.0176 0.206
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0022 0.0083
Schistosoma mansoni hypothetical protein 0.007 0.0096 0.0416
Loa Loa (eye worm) hypothetical protein 0.0042 0.0043 0.051
Brugia malayi mbt repeat family protein 0.0058 0.0073 0.0817
Echinococcus multilocularis protein dispatched 1 0.0106 0.0163 0.0159
Echinococcus granulosus geminin 0.0171 0.0286 0.1104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0022 0.0266
Mycobacterium tuberculosis Conserved protein 0.0153 0.0253 0.0964
Echinococcus granulosus beta LACTamase domain containing family member 0.0153 0.0253 0.0973
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0138 0.5385
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0022 0.0018
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0009 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0022 0.021
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0022 0.021
Brugia malayi nuclear hormone receptor 0.0031 0.0022 0.021
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0046 0.1672
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0138 0.0526
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0138 0.5385
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0022 0.021
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0009 0.0153
Echinococcus multilocularis sterol regulatory element binding protein 0.0093 0.0139 0.0135
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0052 0.0572
Loa Loa (eye worm) hypothetical protein 0.0221 0.0382 0.458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0022 0.0266
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0022 0.0018
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.01 0.1197
Trichomonas vaginalis penicillin-binding protein, putative 0.0153 0.0253 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0046 0.1672
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0014 0.0371
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0093 0.0139 0.166
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.003 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0022 0.0072
Loa Loa (eye worm) hypothetical protein 0.0128 0.0205 0.2455
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0308
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0086 0.0082
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0046 0.1131
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0022 0.0018
Echinococcus multilocularis kinesin family 1 0.1373 0.2559 0.2556
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0014 0.0371
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0009 0.0153
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0088 0.0999
Mycobacterium ulcerans transcriptional regulator 0.1382 0.2575 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0266
Entamoeba histolytica hypothetical protein 0.0112 0.0175 0.4649
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0026 0.0844
Loa Loa (eye worm) hypothetical protein 0.0035 0.003 0.0358
Echinococcus multilocularis tumor protein p63 0.0705 0.1297 0.1294
Echinococcus multilocularis aryl hydrocarbon receptor 0.0128 0.0206 0.0202
Leishmania major GTP-binding protein, putative 0.0024 0.0009 0.0183
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0022 0.0072
Brugia malayi Bromodomain containing protein 0.0042 0.0042 0.0453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0147 0.0242 0.1073
Schistosoma mansoni ap endonuclease 0.0022 0.0005 0.0004
Schistosoma mansoni alpha-glucosidase 0.0169 0.0284 0.1262
Leishmania major importin beta-1 subunit, putative 0.0027 0.0014 0.0371
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0052 0.1916
Echinococcus granulosus Protein patched homolog 1 0.0093 0.0139 0.0527
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0216 0.0371 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.001 0.0024
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0022 0.0083
Echinococcus multilocularis GPCR, family 2 0.007 0.0096 0.0092
Schistosoma mansoni hypothetical protein 0.0151 0.025 0.1108
Echinococcus granulosus snurportin 1 0.035 0.0626 0.2433
Brugia malayi latrophilin 2 splice variant baaae 0.0151 0.025 0.2952
Onchocerca volvulus 0.0047 0.0052 0.1304
Mycobacterium leprae conserved hypothetical protein 0.0153 0.0253 0.0794
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0009 0.0005
Echinococcus multilocularis Niemann Pick C1 protein 0.0308 0.0546 0.0542
Schistosoma mansoni hypothetical protein 0.0112 0.0175 0.0772
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0138 0.0134
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.007 0.0096 0.0092
Schistosoma mansoni alpha-glucosidase 0.0169 0.0284 0.1262
Brugia malayi ecdysteroid receptor 0.0031 0.0022 0.021
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0073 0.0269
Brugia malayi nuclear receptor NHR-88 0.0031 0.0022 0.021
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0052 0.0572
Schistosoma mansoni hypothetical protein 0.0355 0.0634 0.284
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0153 0.0253 0.0964
Loa Loa (eye worm) hypothetical protein 0.0044 0.0047 0.0568
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0009 0.0183
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0026 0.0706
Echinococcus granulosus expressed conserved protein 0.0202 0.0346 0.134
Echinococcus granulosus single minded 2 0.0044 0.0047 0.0167
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0026 0.0084
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0026 0.0844
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0058 0.2146
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0138 0.5385
Schistosoma mansoni patched 1 0.0093 0.0139 0.0607
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0022 0.021
Brugia malayi bHLH-PAS transcription factor 0.0044 0.0047 0.0505
Echinococcus granulosus importin subunit beta 1 0.0033 0.0026 0.0085
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0073 0.031
Loa Loa (eye worm) latrophilin receptor protein 2 0.007 0.0096 0.1152
Echinococcus granulosus survival motor neuron protein 1 0.0461 0.0834 0.325
Brugia malayi RNA, U transporter 1 0.0093 0.014 0.163
Mycobacterium tuberculosis Probable esterase LipL 0.0153 0.0253 0.0964
Mycobacterium leprae Probable lipase LipE 0.0153 0.0253 0.0794
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0009 0.0112
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0266
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0009 0.0021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0175 0.067
Onchocerca volvulus 0.0094 0.0141 0.5169
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0231 0.0401 0.0397
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0058 0.2146
Brugia malayi mbt repeat family protein 0.0058 0.0073 0.0817
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0153 0.0253 0.0964
Loa Loa (eye worm) hypothetical protein 0.0047 0.0052 0.0626
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0231 0.0401 0.1554
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0052 0.0185
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0022 0.0072
Schistosoma mansoni hypothetical protein 0.0022 0.0006 0.001
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.001 0.0027
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0175 0.0772
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0221 0.0382 0.458
Toxoplasma gondii kinesin motor domain-containing protein 0.0178 0.0301 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0005 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0058 0.2146
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0046 0.1672
Schistosoma mansoni hypothetical protein 0.0171 0.0286 0.1272
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0022 0.0083
Plasmodium vivax kinesin-5 0.0178 0.0301 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0058 0.0244
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.0141 0.1645
Mycobacterium tuberculosis Conserved protein 0.0153 0.0253 0.0964
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0022 0.0083
Loa Loa (eye worm) hypothetical protein 0.0103 0.0159 0.1904
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0009 0.0153
Brugia malayi CHE-14 protein 0.0093 0.0139 0.1612
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0022 0.0018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.007 0.0096 0.0361
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0058 0.0695
Brugia malayi beta-lactamase family protein 0.0153 0.0253 0.2987
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0038 0.0131
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0022 0.021
Loa Loa (eye worm) TAR-binding protein 0.0072 0.01 0.1197
Schistosoma mansoni bromodomain containing protein 0.0069 0.0094 0.0405
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.0159 0.0699
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0086 0.0323
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0058 0.2146

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 67.568 uM PubChem BioAssay. Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response screening assay to identify agonists of the Liver-X-Receptor (LXR). (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) > 120 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.299 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 1.4125 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.1331 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 3.6611 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.7279 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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