TDR Targets

Basic information

Technical information

TDR Targets ID: 1208121
Name: 4-(3-fluorophenyl)sulfonyl-N-[(4-methoxypheny l)methyl]piperazine-1-carbothioamide
MW: 423.525 | Formula: C19H22FN3O3S2
H donors: 0 H acceptors: 2 LogP: 2.77 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)CN=C(N1CCN(CC1)S(=O)(=O)c1cccc(c1)F)S
InChi: 1S/C19H22FN3O3S2/c1-26-17-7-5-15(6-8-17)14-21-19(27)22-9-11-23(12-10-22)28(24,25)18-4-2-3-16(20)13-18/h2-8,13H,9-12,14H2,1H3,(H,21,27)
InChiKey: LBHLYLMPPOOELK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-(3-fluorophenyl)sulfonyl-N-[(4-methoxyphenyl)methyl]-1-piperazinecarbothioamide
4-(3-fluorophenyl)sulfonyl-N-(4-methoxybenzyl)piperazine-1-carbothioamide
SMR000364621
T5346313
ZINC03449240
MLS000773882

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)	Epstein-Barr nuclear antigen 1	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Diacylglycerol kinase zeta	0.0094	0.0306	0.0306
Plasmodium vivax	hypothetical protein, conserved	0.015	0.0542	1
Mycobacterium ulcerans	lipase LipD	0.015	0.0542	0.0534
Loa Loa (eye worm)	ceramide kinase	0.0094	0.0306	0.0306
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0063	0.0176	0.3147
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.001	0.0002
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0097	0.032	0.2761
Mycobacterium ulcerans	hypothetical protein	0.2409	1	1
Trypanosoma brucei	protein kinase, putative	0.0055	0.0142	0.1188
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0306	0.0306
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0063	0.0176	0.0168
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0076	0.0076
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0133	0.0468	0.0468
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.015	0.0542	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0125	0.0125
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0063	0.0176	0.1484
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0293	0.114	1
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.032	0.5855
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0076	0.0076
Echinococcus multilocularis	protein dispatched 1	0.0047	0.011	0.011
Onchocerca volvulus		0.0023	0.001	0.0184
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.0116	0.2018
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0063	0.0176	0.1484
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0086	0.0086
Echinococcus granulosus	Diacylglycerol kinase theta	0.0094	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0023	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0023	0.001	0.001
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0055	0.0142	0.0142
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.0063	0.0176	0.0168
Brugia malayi	diacylglycerol kinase	0.0094	0.0306	0.3454
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0041	0.0041
Trypanosoma cruzi	cytochrome P450, putative	0.0102	0.0339	0.2922
Echinococcus multilocularis	expressed conserved protein	0.0091	0.0292	0.0292
Schistosoma mansoni	hypothetical protein	0.0094	0.0306	0.0306
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0055	0.0142	0.1188
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0041	0.0085	0.0684
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.0063	0.0176	0.0168
Schistosoma mansoni	hypothetical protein	0.004	0.008	0.008
Schistosoma mansoni	diacylglycerol kinase zeta iota	0.0094	0.0306	0.0306
Brugia malayi	ImpB/MucB/SamB family protein	0.0043	0.0095	0.1069
Mycobacterium ulcerans	hypothetical protein	0.015	0.0542	0.0534
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.015	0.0542	0.0534
Brugia malayi	Diacylglycerol kinase protein 2	0.0094	0.0306	0.3454
Brugia malayi	hypothetical protein	0.0094	0.0306	0.3454
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.001	0.0112
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0959	0.393	0.3925
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0142	0.2518
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0094	0.0306	0.0306
Loa Loa (eye worm)	TAR-binding protein	0.0133	0.0468	0.0468
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.001	0.0002
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0142	0.2518
Entamoeba histolytica	hypothetical protein	0.0039	0.0076	0.0068
Onchocerca volvulus		0.0031	0.0045	0.0824
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.0063	0.0176	0.0168
Echinococcus granulosus	intermediate filament protein	0.0031	0.0045	0.0045
Schistosoma mansoni	hypothetical protein	0.0031	0.0041	0.0041
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0794	0.3237	0.3237
Echinococcus multilocularis	protein patched	0.0041	0.0086	0.0086
Echinococcus granulosus	dna polymerase eta	0.0043	0.0095	0.0095
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.001	0.0002
Brugia malayi	Eye-specific diacylglycerol kinase	0.0094	0.0306	0.3454
Echinococcus granulosus	cytochrome P450 2K1	0.0063	0.0176	0.0176
Echinococcus multilocularis	acylglycerol kinase, mitochondrial	0.0094	0.0306	0.0306
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.0319	0.3606
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0041	0.0041
Schistosoma mansoni	serine/threonine protein kinase	0.0097	0.032	0.032
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	0.114	1
Giardia lamblia	Kinase, CMGC MAPK	0.0055	0.0142	0.4302
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0008	0.0008
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0201	0.0753	0.0753
Leishmania major	hypothetical protein, conserved	0.0094	0.0306	0.2631
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0045	0.0505
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.0063	0.0176	0.0168
Brugia malayi	hypothetical protein	0.0231	0.0882	0.9969
Brugia malayi	diacylglycerol kinase	0.0094	0.0306	0.3454
Entamoeba histolytica	hypothetical protein	0.0039	0.0076	0.0068
Echinococcus multilocularis		0.0063	0.0176	0.0176
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0063	0.0176	0.0168
Echinococcus multilocularis	Niemann Pick C1 protein	0.0138	0.049	0.049
Trichomonas vaginalis	bmru protein, putative	0.0094	0.0306	0.558
Loa Loa (eye worm)	hypothetical protein	0.015	0.0542	0.0542
Loa Loa (eye worm)	beta-lactamase	0.015	0.0542	0.0542
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.004	0.008	0.008
Brugia malayi	CHE-14 protein	0.0041	0.0086	0.0971
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.032	0.5855
Mycobacterium ulcerans	diacylglycerol kinase	0.0094	0.0306	0.0298
Loa Loa (eye worm)	cytochrome P450 family protein	0.0232	0.0885	0.0885
Echinococcus multilocularis	dna polymerase eta	0.0043	0.0095	0.0095
Echinococcus multilocularis	tar DNA binding protein	0.0133	0.0468	0.0468
Brugia malayi	beta-lactamase family protein	0.015	0.0542	0.612
Brugia malayi	serine/threonine-protein kinase plk-2	0.0097	0.032	0.362
Echinococcus multilocularis	musashi	0.0031	0.0045	0.0045
Brugia malayi	TAR-binding protein	0.0133	0.0468	0.5294
Trypanosoma cruzi	Diacylglycerol kinase catalytic domain containing protein, putative	0.0094	0.0306	0.2631
Mycobacterium tuberculosis	Conserved protein	0.015	0.0542	0.0534
Echinococcus multilocularis	lamin	0.0031	0.0045	0.0045
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0086	0.1463
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.0063	0.0176	0.0168
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.0063	0.0176	0.0168
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.001	0.0002
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.0882	0.0882
Brugia malayi	cytochrome P450	0.0063	0.0176	0.1987
Loa Loa (eye worm)	cytochrome P450	0.0063	0.0176	0.0176
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0063	0.0176	0.0168
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.032	0.5855
Brugia malayi	latrophilin 2 splice variant baaae	0.0066	0.0191	0.2153
Echinococcus multilocularis	Diacylglycerol kinase zeta	0.0094	0.0306	0.0306
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0063	0.0176	0.0168
Leishmania major	DNA polymerase eta, putative	0.0031	0.0041	0.0289
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0085	0.0684
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0008	0.0008
Mycobacterium ulcerans	beta-lactamase	0.015	0.0542	0.0534
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.0063	0.0176	0.0168
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.001	0.0002
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.015	0.0542	0.0534
Loa Loa (eye worm)	hypothetical protein	0.015	0.0542	0.0542
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0063	0.0176	0.0168
Onchocerca volvulus		0.015	0.0542	1
Echinococcus multilocularis	sphingosine kinase 1	0.2409	1	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.0063	0.0176	0.0168
Mycobacterium tuberculosis	Conserved protein	0.015	0.0542	0.0534
Plasmodium vivax	diacylglycerol kinase, putative	0.0094	0.0306	0.5644
Trichomonas vaginalis	D-aminoacylase, putative	0.015	0.0542	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0041	0.0086	0.0086
Mycobacterium tuberculosis	Probable lipase LipE	0.015	0.0542	0.0534
Brugia malayi	MAP kinase sur-1	0.0055	0.0142	0.1608
Toxoplasma gondii	diacylglycerol kinase accessory domain (presumed) domain-containing protein	0.0094	0.0306	0.558
Schistosoma mansoni	ap endonuclease	0.0023	0.0008	0.0008
Brugia malayi	RNA recognition motif domain containing protein	0.0133	0.0468	0.5294
Trichomonas vaginalis	CAMK family protein kinase	0.0048	0.0116	0.2018
Mycobacterium ulcerans	hypothetical protein	0.0023	0.001	0.0002
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0094	0.0306	0.2631
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.032	0.5855
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0063	0.0176	0.0168
Loa Loa (eye worm)	cytochrome P450 family protein	0.0102	0.0339	0.0339
Schistosoma mansoni	hypothetical protein	0.0063	0.0176	0.0176
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0094	0.0306	0.0306
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.0063	0.0176	0.0168
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.0493	0.429
Brugia malayi	Cytochrome P450 family protein	0.0102	0.0339	0.3826
Loa Loa (eye worm)	hypothetical protein	0.015	0.0542	0.0542
Entamoeba histolytica	hypothetical protein	0.0039	0.0076	0.0068
Schistosoma mansoni	diacylglycerol kinase theta	0.0094	0.0306	0.0306
Trypanosoma cruzi	DNA polymerase eta, putative	0.0043	0.0095	0.0767
Schistosoma mansoni	hypothetical protein	0.0166	0.0607	0.0607
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.0063	0.0176	0.0168
Brugia malayi	Cytochrome P450 family protein	0.0232	0.0885	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0097	0.032	0.2761
Trichomonas vaginalis	bmru protein, putative	0.0094	0.0306	0.558
Mycobacterium leprae	conserved hypothetical protein	0.015	0.0542	1
Leishmania major	cytochrome p450-like protein	0.0063	0.0176	0.1484
Toxoplasma gondii	ABC1 family protein	0.015	0.0542	1
Plasmodium falciparum	diacylglycerol kinase, putative	0.0094	0.0306	1
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.0323	0.0323
Schistosoma mansoni	lipoxygenase	0.0125	0.0435	0.0435
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.0063	0.0176	0.0168
Brugia malayi	RNA binding protein	0.0133	0.0468	0.5294
Loa Loa (eye worm)	hypothetical protein	0.015	0.0542	0.0542
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0008	0.0145
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.0468	0.0468
Trichomonas vaginalis	conserved hypothetical protein	0.0094	0.0306	0.558
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.001	0.0018
Echinococcus granulosus	GPCR family 2	0.0031	0.0041	0.0041
Schistosoma mansoni	kinase	0.005	0.0121	0.0121
Schistosoma mansoni	hypothetical protein	0.0031	0.0041	0.0041
Loa Loa (eye worm)	cytochrome P450 family protein	0.0102	0.0339	0.0339
Echinococcus granulosus	Niemann Pick C1 protein	0.0096	0.0316	0.0316
Schistosoma mansoni	sphingoid long chain base kinase	0.2409	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.001	0.0112
Brugia malayi	beta-lactamase family protein	0.015	0.0542	0.612
Trypanosoma cruzi	polo-like protein kinase, putative	0.0097	0.032	0.2761
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.001	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0231	0.0882	0.0882
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.0063	0.0176	0.0168
Trypanosoma brucei	diacylglycerol kinase, putative	0.0094	0.0306	0.2631
Echinococcus granulosus	lamin dm0	0.0031	0.0045	0.0045
Trichomonas vaginalis	diacylglycerol kinase, epsilon, putative	0.0094	0.0306	0.558
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0306	0.0306
Entamoeba histolytica	diacylglycerol kinase, putative	0.0094	0.0306	0.0298
Trypanosoma brucei	cytochrome P450, putative	0.0102	0.0339	0.2922
Trichomonas vaginalis	diacylglycerol kinase, putative	0.0094	0.0306	0.558
Schistosoma mansoni	patched 1	0.0041	0.0086	0.0086
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0008	0.0089
Mycobacterium tuberculosis	Probable esterase LipL	0.015	0.0542	0.0534
Trypanosoma brucei	DNA polymerase eta, putative	0.0043	0.0095	0.0767
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0201	0.0753	0.0753
Trypanosoma cruzi	hypothetical protein, conserved	0.015	0.0542	0.4715
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0125	0.0435	0.0435
Brugia malayi	intermediate filament protein	0.0031	0.0045	0.0505
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0045	0.0045
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.0468	0.0468
Trichomonas vaginalis	diacylglycerol kinase, zeta, iota, putative	0.0094	0.0306	0.558
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0201	0.0753	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0042	0.0042
Plasmodium falciparum	diacylglycerol kinase, putative	0.0094	0.0306	1
Echinococcus multilocularis	mitogen activated protein kinase	0.0055	0.0142	0.0142
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0045	0.0045
Onchocerca volvulus		0.015	0.0542	1
Trypanosoma cruzi	hypothetical protein, conserved	0.015	0.0542	0.4715
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.0063	0.0176	0.0168
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.0142	0.1188
Schistosoma mansoni	hypothetical protein	0.004	0.008	0.008
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0063	0.0176	0.0168
Leishmania major	hypothetical protein, conserved	0.015	0.0542	0.4715
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0125	0.0435	0.0435
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.0468	0.0468
Echinococcus granulosus	expressed conserved protein	0.0091	0.0292	0.0292
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0142	0.2518
Giardia lamblia	Kinase, PLK	0.0097	0.032	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0041	0.0085	0.0684
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.001	0.0018
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.0142	0.1188
Onchocerca volvulus		0.015	0.0542	1
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.0142	0.2518
Schistosoma mansoni	lamin	0.0031	0.0045	0.0045
Onchocerca volvulus		0.0031	0.0045	0.0824
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0123	0.1017
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.032	0.5855
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.001	0.0002
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.0063	0.0176	0.0168
Trypanosoma brucei	polo-like protein kinase	0.0097	0.032	0.2761
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.001	0.0002
Mycobacterium tuberculosis	Conserved protein	0.015	0.0542	0.0534
Echinococcus granulosus	tar DNA binding protein	0.0133	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0045	0.0045
Schistosoma mansoni	hypothetical protein	0.0039	0.0076	0.0076
Echinococcus multilocularis	ceramide kinase	0.0094	0.0306	0.0306
Schistosoma mansoni	DNA polymerase eta	0.0043	0.0095	0.0095
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0063	0.0176	0.0168
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0063	0.0176	0.0168
Onchocerca volvulus		0.0094	0.0306	0.5644
Echinococcus granulosus	mitogen activated protein kinase	0.0055	0.0142	0.0142
Brugia malayi	Cytochrome P450 family protein	0.0063	0.0176	0.1987
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0055	0.0142	0.2518
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0076	0.0076
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.015	0.0542	0.0534
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0097	0.032	0.0313
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0063	0.0176	0.1484
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0097	0.032	0.032
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0008	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0063	0.0176	0.0168
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.0468	0.0468
Echinococcus multilocularis	geminin	0.0166	0.0607	0.0607
Brugia malayi	hypothetical protein	0.0039	0.0076	0.0857
Loa Loa (eye worm)	CYP4Cod1	0.0102	0.0339	0.0339
Echinococcus granulosus	sterol regulatory element binding protein	0.0041	0.0086	0.0086
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0096	0.0316	0.0309
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0041	0.0086	0.0086
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0139	0.0493	0.429
Echinococcus granulosus	Protein patched homolog 1	0.0041	0.0086	0.0086
Brugia malayi	beta-lactamase	0.015	0.0542	0.612
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0094	0.0306	0.2631
Loa Loa (eye worm)	hypothetical protein	0.015	0.0542	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0095	0.0095
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0094	0.0306	0.2631
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.0063	0.0176	0.0168
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0201	0.0753	0.0753
Trypanosoma cruzi	Sphingosine kinase	0.0094	0.0306	0.2631
Trichomonas vaginalis	D-aminoacylase, putative	0.015	0.0542	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.011	0.1249
Mycobacterium tuberculosis	Probable hydrolase	0.015	0.0542	0.0534
Leishmania major	DNA polymerase eta, putative	0.0043	0.0095	0.0767
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0055	0.0142	0.1188
Trypanosoma brucei	Diacylglycerol kinase catalytic domain containing protein, putative	0.0094	0.0306	0.2631
Loa Loa (eye worm)	RNA binding protein	0.0133	0.0468	0.0468
Echinococcus granulosus	acylglycerol kinase mitochondrial	0.0094	0.0306	0.0306
Brugia malayi	Cytochrome P450 family protein	0.0102	0.0339	0.3826
Trypanosoma cruzi	hypothetical protein, conserved	0.0094	0.0306	0.2631
Trypanosoma brucei	hypothetical protein, conserved	0.015	0.0542	0.4715
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0041	0.0467
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.0063	0.0176	0.0168
Leishmania major	mitochondrial DNA polymerase beta	0.0293	0.114	1
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0045	0.0045
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0008	0.0008
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0094	0.0306	0.2631
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0023	0.001	0.001
Mycobacterium ulcerans	hypothetical protein	0.0154	0.0559	0.0552
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0154	0.0559	0.0552
Leishmania major	diacylglycerol kinase-like protein	0.0094	0.0306	0.2631
Schistosoma mansoni	hypothetical protein	0.0031	0.0041	0.0041
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.0063	0.0176	0.0168
Echinococcus granulosus	geminin	0.0166	0.0607	0.0607
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0063	0.0176	0.0168
Plasmodium vivax	diacylglycerol kinase, putative	0.0094	0.0306	0.5644
Trypanosoma cruzi	Sphingosine kinase	0.0094	0.0306	0.2631
Schistosoma mansoni	hypothetical protein	0.0166	0.0607	0.0607
Loa Loa (eye worm)	diacylglycerol kinase 2	0.0094	0.0306	0.0306
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0076	0.0076
Trichomonas vaginalis	diacylglycerol kinase, putative	0.0094	0.0306	0.558
Mycobacterium tuberculosis	Diacylglycerol kinase	0.0094	0.0306	0.0298
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0055	0.0142	0.1188
Schistosoma mansoni	ap endonuclease	0.0023	0.0008	0.0008
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0201	0.0753	0.0753
Trichomonas vaginalis	diacylglycerol kinase, zeta, iota, putative	0.0094	0.0306	0.558
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0041	0.0085	0.0684
Mycobacterium leprae	putative cytochrome p450	0.0063	0.0176	0.312
Leishmania major	cytochrome p450-like protein	0.0102	0.0339	0.2922
Toxoplasma gondii	diacylglycerol kinase, putative	0.0094	0.0306	0.558
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0063	0.0176	0.0168
Trypanosoma cruzi	cytochrome P450, putative	0.0102	0.0339	0.2922
Leishmania major	hypothetical protein, conserved	0.0094	0.0306	0.2631
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.0063	0.0176	0.0168
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.001	0.0002
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.001	0.0002
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0063	0.0176	0.1484
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0293	0.114	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0041	0.0041
Mycobacterium tuberculosis	Probable lipase LipD	0.015	0.0542	0.0534
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0097	0.032	0.5915
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0041	0.0041
Schistosoma mansoni	hypothetical protein	0.0047	0.011	0.011
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0063	0.0176	0.0168
Leishmania major	cytochrome p450-like protein	0.0063	0.0176	0.1484
Onchocerca volvulus		0.0047	0.011	0.204
Entamoeba histolytica	hypothetical protein, conserved	0.2409	1	1
Schistosoma mansoni	diacylglycerol kinase theta	0.0094	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0191	0.0191
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.015	0.0542	0.0542
Echinococcus granulosus	lamin	0.0031	0.0045	0.0045
Trichomonas vaginalis	penicillin-binding protein, putative	0.015	0.0542	1
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.032	0.5855
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.001	0.0002
Trypanosoma cruzi	DNA polymerase eta, putative	0.0031	0.0041	0.0289
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.0882	0.0882
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.0319	0.3606
Mycobacterium ulcerans	esterase/lipase LipP	0.015	0.0542	0.0534
Entamoeba histolytica	diacylglycerol kinase, putative	0.0094	0.0306	0.0298
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0201	0.0753	0.0753
Loa Loa (eye worm)	eye-specific diacylglycerol kinase	0.0094	0.0306	0.0306
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0063	0.0176	0.0168
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0097	0.032	0.032
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.0063	0.0176	0.0168
Trichomonas vaginalis	D-aminoacylase, putative	0.015	0.0542	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0008	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.015	0.0542	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0055	0.0142	0.1188
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0139	0.0493	0.429
Toxoplasma gondii	diacylglycerol kinase catalytic domain-containing protein	0.0094	0.0306	0.558
Echinococcus granulosus	Niemann Pick C1 protein	0.0138	0.049	0.049
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0201	0.0753	0.0753
Trypanosoma brucei	hypothetical protein, conserved	0.0094	0.0306	0.2631
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0063	0.0176	0.0168
Leishmania major	diacylglycerol kinase, putative	0.0094	0.0306	0.2631
Echinococcus multilocularis	Niemann Pick C1 protein	0.0096	0.0316	0.0316
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0102	0.0339	0.0331
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.0063	0.0176	0.0168
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0055	0.0142	0.1188
Schistosoma mansoni	hypothetical protein	0.0066	0.0191	0.0191
Trypanosoma brucei	Sphingosine kinase	0.0094	0.0306	0.2631
Toxoplasma gondii	hypothetical protein	0.0047	0.0111	0.1926
Trichomonas vaginalis	sphingosine kinase, putative	0.0094	0.0306	0.558
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0063	0.0176	0.0168
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0031	0.0041	0.0613
Entamoeba histolytica	hypothetical protein	0.0039	0.0076	0.0068
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0201	0.0753	0.0753
Schistosoma mansoni	lamin	0.0031	0.0045	0.0045
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0142	0.0142
Brugia malayi	Niemann-Pick C1 protein precursor	0.0096	0.0316	0.3575
Mycobacterium leprae	Probable lipase LipE	0.015	0.0542	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0201	0.0753	0.851
Mycobacterium leprae	Conserved hypothetical protein	0.0063	0.0176	0.312
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0063	0.0176	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0319	0.0319
Echinococcus granulosus	ceramide kinase	0.0094	0.0306	0.0306
Entamoeba histolytica	diacylglycerol kinase, putative	0.0094	0.0306	0.0298
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.015	0.0542	0.0534
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0041	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0316	0.0316
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.0319	0.0319
Schistosoma mansoni	sphingosine kinase A B	0.2409	1	1
Entamoeba histolytica	diacylglycerol kinase, putative	0.0094	0.0306	0.0298
Echinococcus granulosus	beta LACTamase domain containing family member	0.015	0.0542	0.0542
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0063	0.0176	0.0168
Echinococcus multilocularis	beta LACTamase domain containing family member	0.015	0.0542	0.0542
Brugia malayi	Ceramide kinase	0.0094	0.0306	0.3454
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0055	0.0142	0.0142
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.015	0.0542	0.0542
Trichomonas vaginalis	CAMK family protein kinase	0.0097	0.032	0.5855
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.001	0.0018
Onchocerca volvulus	Ceramide kinase 1 homolog	0.0094	0.0306	0.5644
Leishmania major	sphingosine kinase A, B, putative	0.0094	0.0306	0.2631
Trichomonas vaginalis	sphingosine kinase, putative	0.0094	0.0306	0.558
Schistosoma mansoni	lipoxygenase	0.0087	0.0278	0.0278
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0063	0.0176	0.1484
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0306	0.0306
Schistosoma mansoni	survival motor neuron protein	0.0047	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.015	0.0542	0.0542
Trichomonas vaginalis	esterase, putative	0.015	0.0542	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0055	0.0142	0.0142
Schistosoma mansoni	hypothetical protein	0.004	0.008	0.008
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.015	0.0542	0.612
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0097	0.032	0.032
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0063	0.0176	0.0168
Mycobacterium tuberculosis	Conserved protein	0.2409	1	1
Schistosoma mansoni	cytochrome P450	0.0063	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.2409	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.001	0.0002
Echinococcus multilocularis	lamin dm0	0.0031	0.0045	0.0045
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0063	0.0176	0.0168
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0008	0.0257

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5.942 um	PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the Epstein-Barr virus nuclear antigen 1 (EBNA-1). (Class of assay: confirmatory) [Related pubchem assays: 2292 (Confirmation (EBNA-1 inhibitors in triplicate)), 2328 (Counterscreen (ZTA inhibitors in triplicate)), 1955 (Summary (EBNA-1 inhibitors))]	ChEMBL.	No reference
IC50 (binding)	> 111.248 um	PUBCHEM_BIOASSAY: Counterscreen for inhibitors of EBNA-1: fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors of the Epstein-Barr virus-encoded protein, ZTA. (Class of assay: confirmatory) [Related pubchem assays: 2292 (Confirmation (EBNA-1 inhibitors in triplicate)), 2328 (Counterscreen (ZTA inhibitors in triplicate)), 1955 (Summary (EBNA-1 inhibitors))]	ChEMBL.	No reference
Potency (functional)	0.0032 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.2944 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1352927

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1208121