Detailed information for compound 1210166

Basic information

Technical information
  • TDR Targets ID: 1210166
  • Name: 2-methyl-1-[12-(2-methylimidazol-1-yl)dodecyl ]imidazole
  • MW: 330.511 | Formula: C20H34N4
  • H donors: 0 H acceptors: 2 LogP: 5.15 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nccn1CCCCCCCCCCCCn1ccnc1C
  • InChi: 1S/C20H34N4/c1-19-21-13-17-23(19)15-11-9-7-5-3-4-6-8-10-12-16-24-18-14-22-20(24)2/h13-14,17-18H,3-12,15-16H2,1-2H3
  • InChiKey: ZBGOWZUVRACNMY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-methyl-1-[12-(2-methyl-1-imidazolyl)dodecyl]imidazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0014 0.0002 0.0041
Brugia malayi RNA, U transporter 1 0.0095 0.0061 0.1614
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0011 0.0248
Trichomonas vaginalis esterase, putative 0.0116 0.0076 0.1976
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0027 0.0026
Plasmodium falciparum importin beta, putative 0.0034 0.0016 0.0412
Trichomonas vaginalis sphingosine kinase, putative 0.0527 0.0381 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0002 0.0041
Trypanosoma brucei ISWI complex protein 0.0016 0.0003 0.0027
Mycobacterium tuberculosis Conserved protein 0.0116 0.0076 0.0076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.0074 0.0073
Schistosoma mansoni hypothetical protein 0.0084 0.0053 0.0052
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0027 0.0673
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0019 0.0463
Trypanosoma cruzi diacylglycerol kinase, putative 0.0527 0.0381 1
Mycobacterium ulcerans hypothetical protein 1.354 1 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0027 0.0026
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0027 0.0026
Schistosoma mansoni apoferritin-2 0.0018 0.0004 0.0002
Mycobacterium ulcerans lipase LipD 0.0116 0.0076 0.0075
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0002 0.0001
Trichomonas vaginalis sphingosine kinase, putative 0.0527 0.0381 1
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0029 0.0012 0.0011
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0004 0.0004
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0002 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0027 0.0673
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0007 0.0007
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0009 0.024
Echinococcus multilocularis sphingosine kinase 1 1.354 1 1
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0029 0.0012 0.0318
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0027 0.0026
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0004 0.5
Onchocerca volvulus 0.0014 0.0002 0.0041
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0029 0.0012 0.0318
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0002 0.0041
Brugia malayi mbt repeat family protein 0.0049 0.0027 0.0719
Loa Loa (eye worm) hypothetical protein 0.0116 0.0076 0.0076
Brugia malayi mbt repeat family protein 0.0049 0.0027 0.0719
Leishmania major diacylglycerol kinase, putative 0.0527 0.0381 1
Schistosoma mansoni ran 0.0025 0.0009 0.0008
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0076 0.1976
Entamoeba histolytica diacylglycerol kinase, putative 0.0527 0.0381 0.0379
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0076 0.1976
Entamoeba histolytica hypothetical protein 0.0112 0.0074 0.0072
Mycobacterium tuberculosis Conserved protein 1.354 1 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0076 0.0076
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0029 0.0012 0.0011
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0116 0.0076 0.0076
Mycobacterium tuberculosis Diacylglycerol kinase 0.0527 0.0381 0.0381
Brugia malayi serine/threonine-protein kinase plk-2 0.011 0.0072 0.1895
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0527 0.0381 0.0381
Mycobacterium tuberculosis Probable hydrolase 0.0116 0.0076 0.0076
Echinococcus multilocularis tumor protein p63 0.0349 0.0249 0.0248
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0042 0.0022 0.0022
Plasmodium falciparum diacylglycerol kinase, putative 0.0527 0.0381 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0027 0.0026
Echinococcus multilocularis ceramide kinase 0.0527 0.0381 0.038
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0072 0.1861
Schistosoma mansoni hypothetical protein 0.03 0.0213 0.0211
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0072 0.1861
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0348 0.0248 0.6511
Loa Loa (eye worm) hypothetical protein 0.0116 0.0076 0.0076
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0032 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0076 0.1976
Echinococcus multilocularis protein dispatched 1 0.01 0.0065 0.0063
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0027 0.0026
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0019 0.0018
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0073 0.0045 0.0045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.0065 0.1709
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0027 0.0026
Echinococcus multilocularis cpg binding protein 0.0033 0.0016 0.0014
Leishmania major hypothetical protein, conserved 0.0527 0.0381 1
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0012 0.0277
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0027 0.0679
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.0076 0.1976
Schistosoma mansoni survival motor neuron protein 0.005 0.0028 0.0026
Schistosoma mansoni sphingosine kinase A B 1.354 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0019 0.0503
Schistosoma mansoni patched 1 0.0087 0.0055 0.0054
Schistosoma mansoni ferritin 0.0018 0.0004 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0027 0.0679
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0004 0.0003
Loa Loa (eye worm) inositol-1 0.0038 0.0019 0.0019
Echinococcus granulosus lamin 0.0029 0.0012 0.0011
Leishmania major hypothetical protein, conserved 0.0116 0.0076 0.1976
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0004 0.0302
Schistosoma mansoni zinc finger protein 0.0016 0.0003 0.0001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0009 0.0199
Echinococcus multilocularis 0.0029 0.0012 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0527 0.0381 1
Mycobacterium tuberculosis Conserved protein 0.0116 0.0076 0.0076
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0116 0.0076 0.0076
Toxoplasma gondii diacylglycerol kinase, putative 0.0527 0.0381 1
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0029 0.0012 0.0277
Plasmodium falciparum diacylglycerol kinase, putative 0.0527 0.0381 1
Schistosoma mansoni hypothetical protein 0.0084 0.0053 0.0052
Mycobacterium leprae Probable lipase LipE 0.0116 0.0076 1
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0527 0.0381 1
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0527 0.0381 0.0379
Trichomonas vaginalis bmru protein, putative 0.0527 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0027 0.0027
Trichomonas vaginalis ran, putative 0.0025 0.0009 0.0199
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0027 0.0719
Loa Loa (eye worm) hypothetical protein 0.0116 0.0076 0.0076
Mycobacterium tuberculosis Probable lipase LipE 0.0116 0.0076 0.0076
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0527 0.0381 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0028 0.0728
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0527 0.0381 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.011 0.0072 0.1895
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.0055 0.0055
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0027 0.0026
Brugia malayi diacylglycerol kinase 0.0527 0.0381 1
Trypanosoma cruzi Sphingosine kinase 0.0527 0.0381 1
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.0074 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0002 0.0041
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0029 0.0012 0.0277
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0002 0.0041
Echinococcus multilocularis beta LACTamase domain containing family member 0.0116 0.0076 0.0075
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0013 0.0013
Brugia malayi beta-lactamase 0.0116 0.0076 0.2009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0001
Schistosoma mansoni inositol monophosphatase 0.0038 0.0019 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0065 0.0064
Brugia malayi CHE-14 protein 0.0087 0.0055 0.1455
Schistosoma mansoni hypothetical protein 0.005 0.0028 0.0026
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0113 0.2933
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0004 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0027 0.3435
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0018 0.0017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0065 0.0064
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0027 0.0026
Echinococcus multilocularis geminin 0.0175 0.012 0.0119
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0527 0.0381 0.0381
Leishmania major sphingosine kinase A, B, putative 0.0527 0.0381 1
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0029 0.0012 0.0469
Leishmania major GTP-binding protein, putative 0.0025 0.0009 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0031 0.0779
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0009 0.0008
Entamoeba histolytica diacylglycerol kinase, putative 0.0527 0.0381 0.0379
Schistosoma mansoni hypothetical protein 0.0175 0.012 0.0119
Trypanosoma brucei polo-like protein kinase 0.011 0.0072 0.1861
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0072 0.1861
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.0065 0.0065
Onchocerca volvulus 0.0014 0.0002 0.0041
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.0171 0.017
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0018
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0027 0.0673
Loa Loa (eye worm) ceramide kinase 0.0527 0.0381 0.0381
Echinococcus granulosus lamin dm0 0.0029 0.0012 0.0011
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0527 0.0381 0.038
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0032 0.0031
Brugia malayi intermediate filament protein 0.0029 0.0012 0.0315
Schistosoma mansoni intermediate filament proteins 0.0029 0.0012 0.001
Trypanosoma cruzi ISWI complex protein 0.0016 0.0003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0065 0.0064
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0002 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0004 0.0003
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0029 0.0012 0.0277
Schistosoma mansoni bromodomain containing protein 0.0067 0.0041 0.0039
Echinococcus multilocularis lamin 0.0029 0.0012 0.0011
Echinococcus multilocularis Diacylglycerol kinase theta 0.0527 0.0381 0.038
Brugia malayi Eye-specific diacylglycerol kinase 0.0527 0.0381 1
Echinococcus granulosus Protein patched homolog 1 0.0087 0.0055 0.0054
Entamoeba histolytica hypothetical protein 0.0027 0.0011 0.0009
Brugia malayi hypothetical protein 0.0244 0.0171 0.4503
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.0076 0.0075
Leishmania major hypothetical protein, conserved 0.0016 0.0003 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Brugia malayi beta-lactamase family protein 0.0116 0.0076 0.2009
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0035 0.0882
Echinococcus multilocularis snurportin 1 0.0358 0.0256 0.0255
Schistosoma mansoni ferritin 0.0018 0.0004 0.0002
Onchocerca volvulus 0.0116 0.0076 0.2009
Brugia malayi CXXC zinc finger family protein 0.003 0.0013 0.0337
Mycobacterium tuberculosis Conserved hypothetical protein 0.0184 0.0127 0.0126
Loa Loa (eye worm) hypothetical protein 0.0034 0.0016 0.0016
Brugia malayi hypothetical protein 0.0527 0.0381 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0291 0.0206 0.0205
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.0248 0.6511
Trichomonas vaginalis diacylglycerol kinase, putative 0.0527 0.0381 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0018 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0017 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0037 0.0036
Onchocerca volvulus 0.0527 0.0381 1
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.0072 0.1861
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0018
Trypanosoma cruzi diacylglycerol kinase, putative 0.0527 0.0381 1
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0072 0.0071
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0002 0.0001
Entamoeba histolytica diacylglycerol kinase, putative 0.0527 0.0381 0.0379
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0072 0.1861
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0018 0.0475
Schistosoma mansoni ferritin light chain 0.0018 0.0004 0.0002
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0016 0.0372
Schistosoma mansoni ran 0.0025 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0527 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0012
Echinococcus multilocularis zinc finger protein 0.0022 0.0007 0.0006
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0207 0.0144 0.0142
Schistosoma mansoni ferritin 0.0018 0.0004 0.0002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0116 0.0076 0.0076
Brugia malayi PHD-finger family protein 0.0027 0.0011 0.0294
Trichomonas vaginalis dullard protein, putative 0.0029 0.0012 0.0277
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0032 0.0852
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0027 0.3435
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0002 0.0041
Mycobacterium leprae conserved hypothetical protein 0.0116 0.0076 1
Entamoeba histolytica hypothetical protein 0.0112 0.0074 0.0072
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0027 0.0026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0002 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0002 0.0041
Schistosoma mansoni cpg binding protein 0.0033 0.0016 0.0014
Schistosoma mansoni ferritin 0.0018 0.0004 0.0002
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0032 0.0031
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0019 0.0463
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0002 0.0001
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0056 0.0032 0.0032
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0027 0.0027
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0002 0.0002
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0016 0.0412
Trypanosoma cruzi hypothetical protein, conserved 0.0527 0.0381 1
Echinococcus granulosus zinc finger protein 0.0022 0.0007 0.0006
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0029 0.0012 0.0011
Trypanosoma brucei diacylglycerol kinase, putative 0.0527 0.0381 1
Schistosoma mansoni inositol monophosphatase 0.0038 0.0019 0.0018
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0116 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0084 0.0053 0.0052
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0019 0.0463
Echinococcus granulosus Niemann Pick C1 protein 0.0203 0.0141 0.014
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0027 0.0673
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0527 0.0381 1
Echinococcus multilocularis expressed conserved protein 0.0191 0.0132 0.0131
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0019 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0025 0.0025
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.0001
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0527 0.0381 0.038
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0011 0.0248
Echinococcus granulosus importin subunit beta 1 0.0034 0.0016 0.0015
Trichomonas vaginalis ferritin, putative 0.0018 0.0004 0.006
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0009 0.0008
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0004 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.0116 0.0076 0.1976
Brugia malayi Inositol-1 0.0038 0.0019 0.0503
Echinococcus multilocularis lamin dm0 0.0029 0.0012 0.0011
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0012 0.0012
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0029 0.0012 0.0011
Schistosoma mansoni kinase 0.0056 0.0032 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0072 0.1861
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.0076 0.1976
Loa Loa (eye worm) beta-lactamase 0.0116 0.0076 0.0076
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0009 0.0008
Leishmania major diacylglycerol kinase-like protein 0.0527 0.0381 1
Trichomonas vaginalis conserved hypothetical protein 0.0527 0.0381 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0116 0.0076 0.0075
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0002 0.0001
Schistosoma mansoni sphingoid long chain base kinase 1.354 1 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0009 0.024
Mycobacterium tuberculosis Probable esterase LipL 0.0116 0.0076 0.0076
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.0074 0.0073
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0016 0.0016
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.0113 0.2933
Loa Loa (eye worm) hypothetical protein 0.0116 0.0076 0.0076
Schistosoma mansoni ferritin light chain 0.0018 0.0004 0.0002
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0004 0.0004
Brugia malayi diacylglycerol kinase 0.0527 0.0381 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.0135 0.0134
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0527 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0527 0.0381 0.0381
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0018 0.0018
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0009 0.0008
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0029 0.0012 0.0318
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0527 0.0381 1
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0076 0.1976
Loa Loa (eye worm) hypothetical protein 0.0244 0.0171 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0055 0.142
Loa Loa (eye worm) hypothetical protein 0.0029 0.0012 0.0012
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0029 0.0012 0.0011
Echinococcus granulosus ferritin 0.0018 0.0004 0.0003
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0027 0.0026
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.0055 0.0054
Onchocerca volvulus 0.0051 0.0029 0.0752
Echinococcus granulosus expressed protein 0.0018 0.0004 0.0003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0116 0.0076 0.0076
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0027 0.0717
Echinococcus granulosus geminin 0.0175 0.012 0.0119
Loa Loa (eye worm) oxidoreductase 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0002 0.0001
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.011 0.0072 0.0071
Loa Loa (eye worm) hypothetical protein 0.0087 0.0055 0.0055
Brugia malayi Ceramide kinase 0.0527 0.0381 1
Onchocerca volvulus 0.0049 0.0027 0.0719
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0018 0.0475
Plasmodium vivax diacylglycerol kinase, putative 0.0527 0.0381 1
Schistosoma mansoni cpg binding protein 0.003 0.0013 0.0011
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0527 0.0381 1
Mycobacterium ulcerans hypothetical protein 0.0184 0.0127 0.0125
Leishmania major mitochondrial DNA polymerase beta 0.0348 0.0248 0.6511
Plasmodium vivax hypothetical protein, conserved 0.0116 0.0076 0.2009
Echinococcus granulosus expressed conserved protein 0.0191 0.0132 0.0131
Loa Loa (eye worm) MBCTL1 0.0056 0.0032 0.0032
Entamoeba histolytica diacylglycerol kinase, putative 0.0527 0.0381 0.0379
Echinococcus multilocularis protein patched 0.0087 0.0055 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0072 0.1861
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0032 0.0031
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0527 0.0381 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0116 0.0076 0.0075
Echinococcus granulosus CTD small phosphatase protein like 0.0029 0.0012 0.0011
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0113 0.2933
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0029 0.0012 0.0318
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0203 0.0141 0.0141
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0116 0.0076 0.2009
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0011 0.0248
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0527 0.0381 0.038
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.0171 0.017
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0029 0.0012 0.0277
Trypanosoma brucei Sphingosine kinase 0.0527 0.0381 1
Onchocerca volvulus 0.0029 0.0012 0.0315
Mycobacterium ulcerans hypothetical protein 0.0049 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0017 0.0017
Brugia malayi Bromodomain containing protein 0.0079 0.005 0.1301
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.0076 0.0075
Entamoeba histolytica hypothetical protein 0.0112 0.0074 0.0072
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0027 0.0026
Onchocerca volvulus 0.005 0.0028 0.0728
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0002 0.0041
Loa Loa (eye worm) hypothetical protein 0.0049 0.0027 0.0027
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0027 0.0027
Echinococcus granulosus snurportin 1 0.0358 0.0256 0.0255
Echinococcus granulosus ceramide kinase 0.0527 0.0381 0.038
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0009 0.024
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0031 0.0779
Trichomonas vaginalis bmru protein, putative 0.0527 0.0381 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0016 0.1949
Echinococcus granulosus tumor protein p63 0.0349 0.0249 0.0248
Trichomonas vaginalis diacylglycerol kinase, putative 0.0527 0.0381 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.011 0.0072 0.1861
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0029 0.0027
Schistosoma mansoni hypothetical protein 0.0358 0.0256 0.0254
Echinococcus granulosus intermediate filament protein 0.0029 0.0012 0.0011
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0002 0.0041
Entamoeba histolytica hypothetical protein, conserved 1.354 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0011 0.0248
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0019 0.0018
Trichomonas vaginalis dullard protein, putative 0.0029 0.0012 0.0277
Echinococcus multilocularis Niemann Pick C1 protein 0.0203 0.0141 0.014
Brugia malayi Bromodomain containing protein 0.004 0.002 0.053
Entamoeba histolytica serine/threonine protein kinase, putative 0.011 0.0072 0.0071
Schistosoma mansoni importin beta-1 0.0034 0.0016 0.0014
Onchocerca volvulus Ceramide kinase 1 homolog 0.0527 0.0381 1
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0029 0.0012 0.0277
Schistosoma mansoni hypothetical protein 0.0527 0.0381 0.0379
Brugia malayi hypothetical protein 0.0112 0.0074 0.1934
Echinococcus granulosus Niemann Pick C1 protein 0.0291 0.0206 0.0205
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0527 0.0381 1
Mycobacterium tuberculosis Conserved protein 0.0116 0.0076 0.0076
Echinococcus granulosus serine:threonine protein kinase PLK1 0.011 0.0072 0.0071
Leishmania major hypothetical protein, conserved 0.0527 0.0381 1
Mycobacterium ulcerans esterase/lipase LipP 0.0116 0.0076 0.0075
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0018
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0018 0.0018
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0004 0.0002
Leishmania major hypothetical protein, conserved 0.0029 0.0012 0.0277
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0002 0.0001
Schistosoma mansoni lamin 0.0029 0.0012 0.001
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0203 0.0141 0.014
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0002 0.0041
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.0072 0.1861
Echinococcus granulosus Diacylglycerol kinase theta 0.0527 0.0381 0.038
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0001
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0009 0.0199
Plasmodium vivax diacylglycerol kinase, putative 0.0527 0.0381 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0017 0.0017
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0032 0.0031
Onchocerca volvulus 0.0049 0.0027 0.0717
Trypanosoma cruzi ISWI complex protein 0.0016 0.0003 0.0027
Schistosoma mansoni hypothetical protein 0.0028 0.0012 0.001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0018 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0017 0.0017
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0012 0.0315
Schistosoma mansoni lamin 0.0029 0.0012 0.001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0038 0.0037
Mycobacterium tuberculosis Possible penicillin-binding protein 0.074 0.0538 0.0538
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0019 0.0463
Trypanosoma cruzi Sphingosine kinase 0.0527 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0002 0.0058
Mycobacterium ulcerans hypothetical protein 0.0116 0.0076 0.0075
Onchocerca volvulus 0.0116 0.0076 0.2009
Toxoplasma gondii ABC1 family protein 0.0116 0.0076 0.2009
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0012 0.0012
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0002 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0027 0.0717
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0072 0.1861
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.0055 0.0054
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0029 0.0012 0.0318
Echinococcus multilocularis expressed protein 0.0018 0.0004 0.0003
Brugia malayi Diacylglycerol kinase protein 2 0.0527 0.0381 1
Entamoeba histolytica Ran family GTPase 0.0025 0.0009 0.0008
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0027 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0027 0.0679
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0004
Onchocerca volvulus 0.003 0.0013 0.0337
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0004 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0348 0.0248 0.6511
Loa Loa (eye worm) hypothetical protein 0.0107 0.007 0.007
Toxoplasma gondii hypothetical protein 0.0056 0.0032 0.0852
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0527 0.0381 0.0379
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0065 0.0064
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.0175 0.012 0.0119
Schistosoma mansoni hypothetical protein 0.0084 0.0053 0.0052
Echinococcus multilocularis musashi 0.0029 0.0012 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0004 0.0003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0034 0.0899
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0009 0.0199
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0019 0.0463
Leishmania major importin beta-1 subunit, putative 0.0027 0.0011 0.0248
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0004 0.0003
Plasmodium vivax importin-beta 2, putative 0.0034 0.0016 0.0412
Onchocerca volvulus 0.0014 0.0002 0.0041
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0002 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0027 0.0717
Onchocerca volvulus 0.0116 0.0076 0.2009
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0016 0.0372
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0038 0.0037
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0009 0.024
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0358 0.0256 0.0256
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0065 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0065 0.0064
Echinococcus multilocularis ferritin 0.0018 0.0004 0.0003
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.011 0.0072 0.0072
Schistosoma mansoni diacylglycerol kinase theta 0.0527 0.0381 0.0379
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0018 0.5
Schistosoma mansoni cpg binding protein 0.0033 0.0016 0.0014
Onchocerca volvulus 0.0029 0.0012 0.0315
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0009 0.0008
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.0135 0.0134
Loa Loa (eye worm) hypothetical protein 0.0049 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.004 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0112 0.0074 0.0072
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0002 0.0001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2523 0.1856 0.1855
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0027 0.0026
Echinococcus granulosus Diacylglycerol kinase zeta 0.0527 0.0381 0.038
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.0076 0.1976
Loa Loa (eye worm) diacylglycerol kinase 2 0.0527 0.0381 0.0381
Giardia lamblia Kinase, PLK 0.011 0.0072 1
Brugia malayi beta-lactamase family protein 0.0116 0.0076 0.2009
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 1.354 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0027 0.0027
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0004 0.0002
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0009 0.0009
Mycobacterium ulcerans beta-lactamase 0.0116 0.0076 0.0075
Mycobacterium tuberculosis Probable lipase LipD 0.0116 0.0076 0.0076
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0027 0.0026
Schistosoma mansoni diacylglycerol kinase theta 0.0527 0.0381 0.0379
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0019 0.0463
Mycobacterium ulcerans diacylglycerol kinase 0.0527 0.0381 0.0379
Schistosoma mansoni zinc finger protein 0.0022 0.0007 0.0006
Brugia malayi Importin beta-1 subunit 0.0034 0.0016 0.0412
Brugia malayi Niemann-Pick C1 protein precursor 0.0203 0.0141 0.371
Entamoeba histolytica hypothetical protein 0.0112 0.0074 0.0072
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0002 0.0041
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0016 0.0015
Schistosoma mansoni apoferritin-2 0.0018 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.0021 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0051 0.0029 0.0029
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0019 0.0018
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0002 0.0001
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0019 0.0463
Echinococcus granulosus cpg binding protein 0.0033 0.0016 0.0014
Trichomonas vaginalis dullard protein, putative 0.0029 0.0012 0.0277

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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