Detailed information for compound 1214740

Basic information

Technical information
  • TDR Targets ID: 1214740
  • Name: N-(4-tert-butylphenyl)-2-oxo-2-(2-oxo-1,3-dih ydroindol-3-yl)acetamide
  • MW: 336.384 | Formula: C20H20N2O3
  • H donors: 2 H acceptors: 3 LogP: 3.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2c(C1C(=O)C(=O)Nc1ccc(cc1)C(C)(C)C)cccc2
  • InChi: 1S/C20H20N2O3/c1-20(2,3)12-8-10-13(11-9-12)21-19(25)17(23)16-14-6-4-5-7-15(14)22-18(16)24/h4-11,16H,1-3H3,(H,21,25)(H,22,24)
  • InChiKey: AIBRXYAOBZOOJC-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(4-tert-butylphenyl)-2-oxo-2-(2-oxoindolin-3-yl)acetamide
  • N-(4-tert-butylphenyl)-2-oxo-2-(2-oxo-3-indolinyl)acetamide
  • N-(4-tert-butylphenyl)-2-keto-2-(2-ketoindolin-3-yl)acetamide
  • N-(4-tert-butylphenyl)-2-oxo-2-(2-oxo-1,3-dihydroindol-3-yl)ethanamide
  • MLS001004643
  • SMR000348217
  • T0503-6936

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) thioredoxin reductase 0.0091 0.0237 0.1255
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0056 0.0196
Toxoplasma gondii exonuclease III APE 0.0023 0.0034 0.0154
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0246 0.0977
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0041 0.0218
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0019 0.0066
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0056 0.0217
Schistosoma mansoni ran 0.0022 0.0032 0.0118
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0207 0.0584 0.1026
Onchocerca volvulus 0.003 0.0056 0.0199
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0034 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0031 0.006 0.0067
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0206 0.109
Schistosoma mansoni ap endonuclease 0.0023 0.0034 0.0129
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Trypanosoma cruzi ISWI complex protein 0.0016 0.0014 0.006
Echinococcus multilocularis orexin receptor type 2 0.003 0.0056 0.0049
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0032 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0167 0.064
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.0056 0.0196
Schistosoma mansoni opsin-like receptor 0.003 0.0056 0.0217
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0046 0.0174
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0045
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0031 0.006 0.0067
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0081 0.0208 0.02
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0031 0.006 0.0067
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Trypanosoma brucei trypanothione reductase 0.0091 0.0237 0.1971
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0326 0.0938 0.1676
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.185 0.5479 1
Echinococcus multilocularis zinc finger protein 0.0023 0.0037 0.0029
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.006 0.0461
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0056 0.0196
Brugia malayi Protein kinase domain containing protein 0.0016 0.0014 0.0073
Giardia lamblia NADH oxidase lateral transfer candidate 0.0031 0.006 0.0251
Schistosoma mansoni adenoreceptor 0.003 0.0056 0.0217
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) RecQ helicase 0.0025 0.0041 0.0218
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0034 0.0182
Brugia malayi Latrophilin receptor protein 2 0.005 0.0117 0.0617
Leishmania major C-8 sterol isomerase-like protein 0.0356 0.1027 0.8721
Echinococcus multilocularis Ankyrin 0.0016 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0126 0.0342 0.1808
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0186 0.0522 0.4351
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0117 0.0439
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0134 0.0366 0.1672
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.023 0.0653 0.8314
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0031 0.0012
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0204 0.081
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0056 0.0298
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0023 0.0035 0.0132
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0046 0.0154
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0186
Schistosoma mansoni smad1 5 8 and 0.0018 0.0019 0.0068
Echinococcus multilocularis neuropeptide s receptor 0.003 0.0056 0.0049
Onchocerca volvulus 0.008 0.0206 0.0898
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0056 0.0217
Loa Loa (eye worm) beta-lactamase 0.008 0.0206 0.109
Schistosoma mansoni opsin-like receptor 0.003 0.0056 0.0217
Echinococcus granulosus microtubule associated protein 2 0.0833 0.245 0.9818
Mycobacterium ulcerans beta-lactamase 0.008 0.0206 0.0334
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0056 0.0298
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0031 0.006 0.0379
Brugia malayi hypothetical protein 0.002 0.0025 0.0134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0052 0.0052
Brugia malayi MH2 domain containing protein 0.0018 0.0019 0.0102
Leishmania major GTP-binding protein, putative 0.0022 0.0032 0.0215
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0056 0.0298
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0014 0.0073
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0052 0.0052
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.029 0.1537
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.0646 0.2565
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0035 0.0111
Schistosoma mansoni P2X receptor subunit 0.0067 0.0167 0.0659
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0031 0.006 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0035 0.0156
Echinococcus multilocularis dnaJ subfamily B 0.0849 0.2496 0.249
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi G-protein coupled receptor 0.003 0.0056 0.0298
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0056 0.0049
Brugia malayi neuropeptide F receptor 0.003 0.0056 0.0298
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0021 0.0014
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0056 0.0196
Trypanosoma brucei lanosterol synthase 0.0224 0.0635 0.5373
Schistosoma mansoni ap endonuclease 0.0023 0.0034 0.0129
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0021 0.0068
Trichomonas vaginalis glutathione reductase, putative 0.0031 0.006 0.0251
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0034 0.0109
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0056 0.0196
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0052 0.0389
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0162
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0014 0.0006
Echinococcus multilocularis g protein coupled receptor 0.003 0.0056 0.0049
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0406 0.1177 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.004 0.0155
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0038 0.0271
Echinococcus granulosus tm gpcr rhodopsin 0.0532 0.1552 0.6208
Schistosoma mansoni hypothetical protein 0.0504 0.147 0.5887
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Toxoplasma gondii histone lysine-specific demethylase 0.0023 0.0035 0.0161
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0079 0.0338
Schistosoma mansoni hypothetical protein 0.0109 0.029 0.1156
Schistosoma mansoni amine oxidase 0.0023 0.0035 0.0132
Trypanosoma cruzi lanosterol synthase, putative 0.0224 0.0635 0.5373
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0149 0.0411 0.071
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.0484
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.016 0.0152
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0276
Brugia malayi chromobox protein homolog 3 0.0038 0.0079 0.0419
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0056 0.0217
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0023 0.0035 0.0132
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0031 0.006 0.0461
Trypanosoma brucei C-8 sterol isomerase, putative 0.0356 0.1027 0.8721
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.023 0.0653 0.1152
Trypanosoma brucei ISWI complex protein 0.0016 0.0014 0.006
Echinococcus granulosus histone lysine methyltransferase setb 0.0111 0.0298 0.1168
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0057 0.0435
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0246 0.0239
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0037 0.0196
Onchocerca volvulus 0.003 0.0056 0.0199
Loa Loa (eye worm) hypothetical protein 0.005 0.0117 0.0617
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Plasmodium falciparum importin beta, putative 0.003 0.0055 0.0213
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0052 0.0389
Onchocerca volvulus 0.0734 0.2155 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0052 0.0276
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0052 0.0276
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) glutathione reductase 0.0091 0.0237 0.1255
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0186 0.0522 0.2067
Onchocerca volvulus 0.008 0.0206 0.0898
Plasmodium falciparum thioredoxin reductase 0.0091 0.0237 0.1803
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0032 0.0024
Echinococcus granulosus neuropeptide receptor 0.003 0.0056 0.0196
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0186 0.0522 0.2761
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0162
Schistosoma mansoni hypothetical protein 0.0014 0.0007 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0016 0.0008
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0019 0.0066
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0056 0.0049
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0056 0.0298
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0513 0.1495 0.2697
Loa Loa (eye worm) hypothetical protein 0.003 0.0057 0.0304
Toxoplasma gondii NADPH-glutathione reductase 0.0031 0.006 0.0379
Loa Loa (eye worm) MH2 domain-containing protein 0.0258 0.0736 0.3896
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0034 0.0238
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0162
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Echinococcus multilocularis snurportin 1 0.0316 0.0908 0.0902
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0034 0.0149
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0052 0.0052
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.0321 0.262
Schistosoma mansoni biogenic amine receptor 0.003 0.0056 0.0217
Brugia malayi SWIRM domain containing protein 0.0023 0.0035 0.0186
Echinococcus multilocularis cpg binding protein 0.0065 0.016 0.0153
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0056 0.0196
Entamoeba histolytica Ran family GTPase 0.0022 0.0032 0.0215
Loa Loa (eye worm) transcription factor SMAD2 0.0258 0.0736 0.3896
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0117 0.0109
Schistosoma mansoni chromobox protein 0.0067 0.0167 0.0662
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0072 0.0281
Onchocerca volvulus 0.003 0.0055 0.0192
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0186
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.0646 0.0639
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0031 0.006 0.0461
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0046 0.0185
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0204 0.169
Schistosoma mansoni hypothetical protein 0.0021 0.003 0.011
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0019 0.0011
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0031 0.006 0.0067
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Schistosoma mansoni cpg binding protein 0.0065 0.016 0.0633
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.0646 0.258
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0207 0.0584 0.1026
Plasmodium falciparum phenylalanine--tRNA ligase 0.0153 0.0423 0.3424
Echinococcus multilocularis serotonin receptor 0.003 0.0056 0.0049
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0186 0.0522 0.0515
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0228 0.0646 0.3418
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0072 0.0065
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Onchocerca volvulus 0.0023 0.0035 0.01
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0052 0.0228
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0056 0.0049
Plasmodium falciparum thioredoxin reductase 0.0031 0.006 0.0261
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0056 0.0196
Leishmania major hypothetical protein, conserved 0.0016 0.0014 0.006
Echinococcus granulosus g protein coupled receptor 0.0274 0.0783 0.3117
Echinococcus granulosus nuclear factor of activated T cells 5 0.0081 0.0208 0.0805
Schistosoma mansoni neuropeptide receptor 0.003 0.0056 0.0217
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0206 0.0334
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0056 0.0196
Entamoeba histolytica hypothetical protein 0.0035 0.0072 0.0562
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0056 0.0049
Brugia malayi Heterochromatin protein 1 0.0067 0.0167 0.0886
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0088 0.0378
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.006 0.0233
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0056 0.0298
Leishmania major hypothetical protein, conserved 0.003 0.0057 0.0435
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.1177 1
Onchocerca volvulus 0.006 0.0144 0.061
Brugia malayi Death domain containing protein 0.0016 0.0014 0.0073
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.1177 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0031 0.006 0.0261
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0052 0.0052
Echinococcus multilocularis neuropeptide receptor 0.003 0.0056 0.0049
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0406 0.1177 0.6228
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0056 0.0196
Brugia malayi MH1 domain containing protein 0.0018 0.0019 0.0102
Brugia malayi Dopamine receptor protein 2 0.003 0.0056 0.0298
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0117 0.0109
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0014 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Brugia malayi Bromodomain containing protein 0.0039 0.0084 0.0444
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0056 0.0049
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0034 0.0024
Brugia malayi hypothetical protein 0.003 0.0057 0.0304
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0056 0.0217
Echinococcus granulosus sex peptide receptor 0.003 0.0056 0.0196
Brugia malayi glutathione reductase 0.0091 0.0237 0.1255
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0034 0.0238
Mycobacterium ulcerans lipase LipD 0.008 0.0206 0.0334
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0167 0.064
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0052 0.0389
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0036 0.0188
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0056 0.0298
Schistosoma mansoni hypothetical protein 0.0016 0.0014 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Mycobacterium leprae conserved hypothetical protein 0.008 0.0206 0.2301
Echinococcus multilocularis importin subunit beta 1 0.003 0.0055 0.0048
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0204 0.169
Entamoeba histolytica hypothetical protein 0.0035 0.0072 0.0562
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0206 0.0798
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0056 0.0217
Echinococcus multilocularis Smad4 0.0018 0.0019 0.0012
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0057 0.0435
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0052 0.0389
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0027 0.0006
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0206 0.0334
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0031 0.006 0.0461
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.185 0.5479 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0019 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Brugia malayi sulfakinin receptor protein 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.008 0.0206 0.109
Echinococcus multilocularis chromobox protein 1 0.0067 0.0167 0.016
Echinococcus granulosus hypothetical protein 0.003 0.0056 0.0196
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0056 0.0049
Toxoplasma gondii thioredoxin reductase 0.0091 0.0237 0.1902
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0026 0.0093
Echinococcus granulosus Smad4 0.0018 0.0019 0.0047
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0206 0.0334
Leishmania major hypothetical protein, conserved 0.008 0.0206 0.1705
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.006 0.0461
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Plasmodium vivax thioredoxin reductase, putative 0.0091 0.0237 0.1898
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0088 0.0345
Schistosoma mansoni hypothetical protein 0.0035 0.0072 0.0281
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0032 0.0215
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0056 0.0298
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.0232 0.0902
Echinococcus granulosus importin subunit beta 1 0.003 0.0055 0.0191
Brugia malayi Dopamine receptor protein 1 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.0111 0.0298 0.1577
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0206 0.0334
Toxoplasma gondii ABC1 family protein 0.008 0.0206 0.1633
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.0274 0.0783 0.4145
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0021 0.0068
Schistosoma mansoni hypothetical protein 0.003 0.0056 0.0217
Schistosoma mansoni amine GPCR 0.003 0.0056 0.0217
Schistosoma mansoni hypothetical protein 0.003 0.0056 0.0217
Echinococcus granulosus cpg binding protein 0.0065 0.016 0.0614
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.004 0.0155
Trichomonas vaginalis helicase, putative 0.0013 0.0007 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus granulosus chromobox protein 1 0.0067 0.0167 0.0643
Brugia malayi Melatonin receptor type 1A 0.003 0.0056 0.0298
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0041 0.0034
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.006 0.0461
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.006 0.0461
Treponema pallidum NADH oxidase 0.0031 0.006 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0056 0.0049
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0186 0.0522 0.2083
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0023 0.0035 0.0156
Schistosoma mansoni hypothetical protein 0.0849 0.2496 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.0298 0.1186
Plasmodium falciparum glutathione reductase 0.0091 0.0237 0.1803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Schistosoma mansoni hypothetical protein 0.0316 0.0908 0.3634
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0032 0.0097
Schistosoma mansoni Smad4 0.0018 0.0019 0.0068
Schistosoma mansoni smad1 5 8 and 0.0018 0.0019 0.0068
Onchocerca volvulus 0.008 0.0206 0.0898
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0167 0.064
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Brugia malayi G-protein coupled receptor 0.003 0.0056 0.0298
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0019 0.0012
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0034 0.013
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0031 0.006 0.0261
Onchocerca volvulus 0.003 0.0056 0.0199
Echinococcus granulosus neuropeptide receptor 0.003 0.0056 0.0196
Onchocerca volvulus 0.003 0.0056 0.0199
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0035 0.0111
Onchocerca volvulus 0.003 0.0056 0.0199
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0204 0.169
Brugia malayi hypothetical protein 0.0023 0.0035 0.0186
Echinococcus granulosus neuropeptide receptor A26 0.003 0.0056 0.0196
Echinococcus multilocularis sex peptide receptor 0.003 0.0056 0.0049
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0014 0.0026
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0111 0.0298 0.0291
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0035 0.0156
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0032 0.0126
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0036 0.0188
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0117 0.0617
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0276
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0406 0.1177 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.0023 0.0035 0.0028
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0056 0.0196
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.0056 0.0049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Onchocerca volvulus 0.003 0.0056 0.0199
Echinococcus granulosus snurportin 1 0.0316 0.0908 0.3621
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Schistosoma mansoni hypothetical protein 0.005 0.0117 0.0458
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0056 0.0298
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0052 0.0228
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.0908 0.4808
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0032 0.0015
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0034 0.0019
Loa Loa (eye worm) hypothetical protein 0.008 0.0206 0.109
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0204 0.1082
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0056 0.0196
Echinococcus multilocularis thioredoxin glutathione reductase 0.0091 0.0239 0.0231
Mycobacterium ulcerans dehydrogenase 0.0023 0.0035 0.0021
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Plasmodium vivax SET domain protein, putative 0.0094 0.0246 0.1973
Echinococcus granulosus g protein coupled receptor 0.003 0.0056 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0032 0.0168
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.245 0.9818
Schistosoma mansoni amine GPCR 0.003 0.0056 0.0217
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0052 0.0052
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0056 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0159 0.044 0.233
Echinococcus multilocularis smad 0.0018 0.0019 0.0012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0073
Echinococcus granulosus orexin receptor type 2 0.003 0.0056 0.0196
Schistosoma mansoni amine GPCR 0.003 0.0056 0.0217
Brugia malayi Serotonin receptor 0.0474 0.1381 0.7309
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0246 0.1977
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0034 0.0238
Mycobacterium leprae Probable lipase LipE 0.008 0.0206 0.2301
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0031 0.006 0.0374
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.0646 0.2565
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0117 0.0439
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.004 0.0155
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0056 0.0217
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0406 0.1177 0.117
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.1177 0.5447
Echinococcus granulosus fmrfamide receptor 0.003 0.0056 0.0196
Echinococcus granulosus zinc finger protein 0.0023 0.0037 0.0118
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0019 0.0046
Trichomonas vaginalis set domain proteins, putative 0.0734 0.2155 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0057 0.0235
Onchocerca volvulus 0.003 0.0056 0.0199
Loa Loa (eye worm) hypothetical protein 0.008 0.0206 0.109
Brugia malayi Uncoordinated protein 44 0.0016 0.0014 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Schistosoma mansoni amine GPCR 0.003 0.0056 0.0217
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.185 0.5479 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0206 0.0334
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.0646 0.258
Plasmodium falciparum glutathione reductase 0.0031 0.006 0.0261
Echinococcus granulosus g protein coupled receptor 0.003 0.0056 0.0196
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0056 0.0049
Onchocerca volvulus 0.003 0.0056 0.0199
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0056 0.0217
Brugia malayi Smad1 0.0018 0.0019 0.0102
Brugia malayi RE15519p 0.003 0.0056 0.0298
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0117 0.0617
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0162
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.0021 0.0014
Echinococcus multilocularis geminin 0.0504 0.147 0.1464
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0057 0.0235
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Onchocerca volvulus 0.003 0.0056 0.0199
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.004 0.0155
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.004 0.0155
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0056 0.0217
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0035 0.0245
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0023 0.0035 0.0041
Brugia malayi follicle stimulating hormone receptor 0.0283 0.0809 0.4281
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.006 0.0067
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0056 0.0298
Schistosoma mansoni zinc finger protein 0.0016 0.0014 0.0045
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0056 0.0217
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0111 0.0298 0.1186
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.006 0.0461
Loa Loa (eye worm) hypothetical protein 0.0039 0.0084 0.0445
Loa Loa (eye worm) hypothetical protein 0.0406 0.1177 0.6228
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0104 0.0097
Echinococcus multilocularis g protein coupled receptor 0.003 0.0056 0.0049
Trichomonas vaginalis ran, putative 0.0022 0.0032 0.0117
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0041 0.0162
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.004 0.0155
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0206 0.0334
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0186 0.0522 0.4354
Schistosoma mansoni hypothetical protein 0.005 0.0117 0.0458
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0206 0.0929
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0035 0.0021
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0032 0.0215
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0079 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0206 0.0929
Leishmania major lanosterol synthase, putative 0.0224 0.0635 0.5373
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0056 0.0217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.004 0.0155
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0167 0.0749
Loa Loa (eye worm) hypothetical protein 0.0073 0.0183 0.0969
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.0809 0.4281
Schistosoma mansoni chromobox protein 0.0067 0.0167 0.0662
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Onchocerca volvulus 0.003 0.0056 0.0199
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0303 0.087 0.1551
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0027 0.0046 0.0254
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.0356 0.1027 0.5435
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0204 0.1082
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0056 0.0298
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.0646 0.258
Brugia malayi Dopamine receptor 0.003 0.0056 0.0298
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0056 0.0049
Loa Loa (eye worm) hypothetical protein 0.0159 0.044 0.233
Echinococcus granulosus thioredoxin glutathione reductase 0.0091 0.0239 0.093
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0034 0.0238
Schistosoma mansoni netrin receptor unc5 0.0016 0.0014 0.0046
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0031 0.0012
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0023 0.0035 0.0156
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0032 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Echinococcus granulosus serotonin receptor 0.003 0.0056 0.0196
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0019 0.0012
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0291
Mycobacterium tuberculosis Conserved protein 0.008 0.0206 0.0334
Onchocerca volvulus 0.003 0.0056 0.0199
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0056 0.0217
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0144 0.0764
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0032 0.0215
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0206 0.0929
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0056 0.0298
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0072 0.0261
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0406 0.1177 1
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0206 0.0929
Brugia malayi CXXC zinc finger family protein 0.006 0.0144 0.0764
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Onchocerca volvulus 0.003 0.0056 0.0199
Brugia malayi Pre-SET motif family protein 0.0645 0.1889 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0057 0.0435
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0021 0.0054
Schistosoma mansoni hypothetical protein 0.0504 0.147 0.5887
Brugia malayi putative neuropeptide receptor 0.003 0.0056 0.0298
Echinococcus granulosus somatostatin receptor 0.003 0.0056 0.0196
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0204 0.169
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0056 0.0217
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0056 0.0298
Schistosoma mansoni neuropeptide receptor 0.003 0.0056 0.0217
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0052 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Loa Loa (eye worm) hypothetical protein 0.0047 0.0107 0.0568
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Mycobacterium tuberculosis Possible oxidoreductase 0.0023 0.0035 0.0021
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0052 0.0052
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0035 0.0041
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0056 0.0049
Schistosoma mansoni biogenic amine receptor 0.003 0.0056 0.0217
Onchocerca volvulus Neuropeptide F receptor homolog 0.003 0.0056 0.0199
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0035 0.0245
Echinococcus granulosus dnaJ subfamily B 0.0849 0.2496 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0056 0.0217
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.0167 0.0886
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0056 0.0049
Schistosoma mansoni neuropeptide receptor 0.003 0.0056 0.0217
Entamoeba histolytica hypothetical protein 0.0024 0.0038 0.0271
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0016 0.0082
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0032 0.0024
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0291
Echinococcus granulosus 7tm_1 domain containing protein 0.0304 0.0873 0.3477
Brugia malayi larval opioid receptor 0.003 0.0056 0.0298
Mycobacterium ulcerans hypothetical protein 0.0029 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.0056 0.0049
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0014 0.0006
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0056 0.0196
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0206 0.0929
Brugia malayi PHD-finger family protein 0.0029 0.0053 0.0281
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0056 0.0217
Plasmodium falciparum phenylalanine--tRNA ligase 0.0186 0.0522 0.4285
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0018 0.0054
Schistosoma mansoni bromodomain containing protein 0.0068 0.017 0.0674
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0038 0.0148
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0031 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0206 0.1705
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.003 0.0158
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0056 0.0298
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0406 0.1177 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0056 0.0049
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0167 0.0159
Mycobacterium tuberculosis Probable dehydrogenase 0.0207 0.0584 0.1026
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0056 0.0217
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0206 0.0817
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0052 0.0052
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0046 0.0038
Echinococcus multilocularis fmrfamide receptor 0.003 0.0056 0.0049
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0228 0.0646 0.3418
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0056 0.0196
Echinococcus granulosus bloom syndrome protein 0.0025 0.0041 0.0136
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0019 0.0102
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0077 0.0278
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0016 0.0033
Brugia malayi amine oxidase, flavin-containing family protein 0.0023 0.0035 0.0186
Brugia malayi Pre-SET motif family protein 0.0094 0.0246 0.1301
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0056 0.0196
Loa Loa (eye worm) hypothetical protein 0.008 0.0206 0.109
Schistosoma mansoni hypothetical protein 0.005 0.0117 0.0458
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0056 0.0049
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0034 0.0027
Loa Loa (eye worm) hypothetical protein 0.0021 0.0031 0.0162
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Trichomonas vaginalis chromobox protein, putative 0.0067 0.0167 0.0749
Onchocerca volvulus 0.003 0.0056 0.0199
Echinococcus multilocularis 0.0023 0.0035 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0019 0.0047
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0055 0.0414
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Leishmania major importin beta-1 subunit, putative 0.0024 0.0038 0.0271
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0052 0.0276
Mycobacterium tuberculosis Probable oxidoreductase 0.023 0.0653 0.1152
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0056 0.0298
Brugia malayi ORL1-like opioid receptor 0.003 0.0056 0.0298
Onchocerca volvulus 0.003 0.0056 0.0199
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0034 0.0238
Schistosoma mansoni cpg binding protein 0.006 0.0144 0.0569
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0186
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0406 0.1177 1
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0021 0.011
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0056 0.0196
Mycobacterium tuberculosis Conserved protein 0.008 0.0206 0.0334
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0105 0.0279 0.1108
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0104 0.0389
Echinococcus multilocularis somatostatin receptor 0.003 0.0056 0.0049
Schistosoma mansoni P2X receptor subunit 0.0067 0.0167 0.0659
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0034 0.0182
Brugia malayi Importin beta-1 subunit 0.003 0.0055 0.0291
Schistosoma mansoni amine GPCR 0.003 0.0056 0.0217
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0272 0.0778 1
Schistosoma mansoni zinc finger protein 0.0023 0.0037 0.0138
Brugia malayi CHD4 protein 0.0016 0.0016 0.0082
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0052 0.0389
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0077 0.0069
Onchocerca volvulus 0.003 0.0056 0.0199
Echinococcus multilocularis GPCR, family 2 0.005 0.0117 0.0109
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0056 0.0196
Schistosoma mansoni importin beta-1 0.003 0.0055 0.0211
Brugia malayi G protein-coupled receptor 0.003 0.0056 0.0298
Onchocerca volvulus 0.0274 0.0783 0.3593
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0056 0.0196
Brugia malayi GnHR receptor homolog 0.003 0.0056 0.0298
Onchocerca volvulus 0.0029 0.0052 0.0179
Plasmodium vivax glutathione reductase, putative 0.0091 0.0237 0.1898
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0056 0.0298
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0056 0.0049
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0406 0.1177 0.471
Echinococcus granulosus g protein coupled receptor 0.003 0.0056 0.0196
Leishmania major trypanothione reductase 0.0091 0.0237 0.1971
Loa Loa (eye worm) hypothetical protein 0.0016 0.0014 0.0075
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0038 0.0148
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0207 0.0584 0.1026
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0206 0.0199
Loa Loa (eye worm) hypothetical protein 0.008 0.0206 0.109
Echinococcus multilocularis g protein coupled receptor 0.003 0.0056 0.0049
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Echinococcus multilocularis g protein coupled receptor 0.0274 0.0783 0.0776
Schistosoma mansoni neuropeptide receptor 0.003 0.0056 0.0217
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0206 0.1705
Echinococcus granulosus chromobox protein 1 0.0067 0.0167 0.0643
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.0646 0.0639
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.006 0.032
Schistosoma mansoni myosin xvIII 0.003 0.0056 0.0217
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0032 0.0098
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0038 0.0148
Brugia malayi Calcitonin receptor-like protein seb-1 0.0159 0.044 0.233
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0206 0.0334
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0056 0.0049
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.023 0.0653 0.1152
Brugia malayi RNA, U transporter 1 0.0084 0.0218 0.1152
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0206 0.0817
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0056 0.0196
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0056 0.0049
Echinococcus multilocularis chromobox protein 1 0.0067 0.0167 0.016
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0134 0.0366 0.1457
Schistosoma mansoni cpg binding protein 0.0065 0.016 0.0633
Mycobacterium ulcerans hypothetical protein 0.008 0.0206 0.0334
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi Thioredoxin reductase 0.0091 0.0237 0.1255
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0019 0.0047
Echinococcus multilocularis allatostatin A receptor 0.003 0.0056 0.0049
Schistosoma mansoni biogenic amine receptor 0.003 0.0056 0.0217
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0186 0.0522 0.2761
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0406 0.1177 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0091 0.0237 0.0391
Trypanosoma cruzi trypanothione reductase, putative 0.0091 0.0237 0.1971
Brugia malayi beta-lactamase family protein 0.008 0.0206 0.109
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi Serotonin receptor 0.003 0.0056 0.0298
Echinococcus granulosus neuropeptide s receptor 0.003 0.0056 0.0196
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0031 0.006 0.0213
Loa Loa (eye worm) hypothetical protein 0.0182 0.0509 0.2692
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0056 0.0217
Schistosoma mansoni amine oxidase 0.0023 0.0035 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0079 0.0338
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0056 0.0217
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.008 0.0206 0.109
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Echinococcus multilocularis neuropeptide receptor 0.003 0.0056 0.0049
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0645 0.1889 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0204 0.0197
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0031 0.006 0.0374
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0031 0.0012
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.0056 0.0049
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0167 0.0159
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.0038 0.0079 0.0419
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0034 0.0019
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Brugia malayi hypothetical protein 0.0035 0.0072 0.0383
Brugia malayi MH2 domain containing protein 0.0018 0.0019 0.0102
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0406 0.1177 1
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0056 0.0217
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0052 0.0389
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0206 0.109
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0041 0.0162
Chlamydia trachomatis phenylalanine--tRNA ligase subunit alpha 0.185 0.5479 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0019 0.0102
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0014 0.0026
Echinococcus granulosus smad 0.0018 0.0019 0.0047
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0057 0.0353
Echinococcus granulosus g-protein coupled receptor 0.003 0.0056 0.0196
Trypanosoma cruzi ISWI complex protein 0.0016 0.0014 0.006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0159 0.044 0.233
Entamoeba histolytica hypothetical protein 0.0035 0.0072 0.0562
Schistosoma mansoni hypothetical protein 0.003 0.0056 0.0217
Brugia malayi beta-lactamase family protein 0.008 0.0206 0.109
Brugia malayi MH2 domain containing protein 0.0258 0.0736 0.3896
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0014 0.0046
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0055 0.0331
Schistosoma mansoni smad 0.0018 0.0019 0.0068
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0134 0.0366 0.1672
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.016 0.0611
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Schistosoma mansoni hypothetical protein 0.003 0.0056 0.0217
Echinococcus granulosus allatostatin A receptor 0.003 0.0056 0.0196
Onchocerca volvulus 0.0105 0.0279 0.1237
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0032 0.0131
Brugia malayi hypothetical protein 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Brugia malayi Bromodomain containing protein 0.008 0.0206 0.1092
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0207 0.0584 0.1026
Plasmodium vivax importin-beta 2, putative 0.003 0.0055 0.0326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0032 0.0168
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0023 0.0035 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0046 0.0185
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0027 0.0006
Echinococcus granulosus geminin 0.0504 0.147 0.5878
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0204 0.0791
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0056 0.0196
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0056 0.0196
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0056 0.0298
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0056 0.0298
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0356 0.1027 0.8721
Onchocerca volvulus 0.003 0.0056 0.0199
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0186
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0134 0.0366 0.3006
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.003 0.0056 0.0199
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0023 0.0035 0.0028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0027 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0056 0.0217
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0055 0.0414
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0088 0.0378
Brugia malayi AKH receptor 0.003 0.0056 0.0298
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0167 0.0159
Echinococcus multilocularis fmrfamide receptor 0.003 0.0056 0.0049
Mycobacterium tuberculosis Conserved protein 0.008 0.0206 0.0334
Echinococcus granulosus GPCR family 2 0.005 0.0117 0.0439
Trichomonas vaginalis mercuric reductase, putative 0.0031 0.006 0.0251
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0056 0.0217
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0206 0.0334
Schistosoma mansoni smad1 5 8 and 0.0018 0.0019 0.0068
Brugia malayi SET domain containing protein 0.0016 0.0014 0.0072
Schistosoma mansoni P2X receptor subunit 0.0067 0.0167 0.0659
Plasmodium vivax hypothetical protein, conserved 0.008 0.0206 0.1629
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0014 0.0048
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0206 0.1705
Mycobacterium tuberculosis Probable reductase 0.0207 0.0584 0.1026
Loa Loa (eye worm) Smad1 0.0018 0.0019 0.0102
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0356 0.1027 0.5435
Mycobacterium ulcerans monoamine oxidase 0.0023 0.0035 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0035 0.0186
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0207 0.0584 0.7387
Echinococcus granulosus Ankyrin 0.0016 0.0014 0.0027
Brugia malayi neuropeptide F receptor 0.003 0.0056 0.0298
Schistosoma mansoni hypothetical protein 0.005 0.0117 0.0458
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0021 0.0075
Trypanosoma cruzi lanosterol synthase, putative 0.0224 0.0635 0.5373
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0204 0.169
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0056 0.0298
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.245 0.2445
Onchocerca volvulus 0.003 0.0056 0.0199
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0406 0.1177 0.4699
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0027 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0354 0.1408
Entamoeba histolytica hypothetical protein 0.0035 0.0072 0.0562
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0007 0.0002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.006 0.0461
Brugia malayi beta-lactamase 0.008 0.0206 0.109
Chlamydia trachomatis protoporphyrinogen oxidase 0.0023 0.0035 0.0021
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0056 0.0049
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0031 0.006 0.0067
Schistosoma mansoni P2X receptor subunit 0.0067 0.0167 0.0659
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0056 0.0049
Loa Loa (eye worm) hypothetical protein 0.0109 0.029 0.1537
Echinococcus granulosus death domain containing protein 0.0016 0.0014 0.0026
Leishmania major UDP-galactopyranose mutase 0.0023 0.0035 0.0245
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0056 0.0217
Plasmodium falciparum protoporphyrinogen oxidase 0.0023 0.0035 0.0041
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0031 0.006 0.0461
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0298
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0057 0.0348
Loa Loa (eye worm) hypothetical protein 0.0029 0.0052 0.0276
Schistosoma mansoni opsin-like receptor 0.003 0.0056 0.0217
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0206 0.0334
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0016 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0056 0.0196
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0034 0.013
Trichomonas vaginalis esterase, putative 0.008 0.0206 0.0929
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.004 0.0155
Echinococcus multilocularis serotonin receptor 0.003 0.0056 0.0049
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0326 0.0938 0.1676
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0056 0.0049
Schistosoma mansoni ran 0.0022 0.0032 0.0118
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0056 0.0049
Mycobacterium ulcerans oxidoreductase 0.0023 0.0035 0.0021
Schistosoma mansoni histamine h1 receptor 0.003 0.0056 0.0217
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0532 0.1552 0.1546
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.006 0.0067
Brugia malayi MH1 domain containing protein 0.0018 0.0019 0.0102

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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