Detailed information for compound 1226653

Basic information

Technical information
  • TDR Targets ID: 1226653
  • Name: 4-[4-[di(phenyl)methyl]piperazine-1-carbonyl] -5-methyl-1,2-oxazole-3-carbohydrazide
  • MW: 419.476 | Formula: C23H25N5O3
  • H donors: 2 H acceptors: 3 LogP: 2.09 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NNC(=O)c1noc(c1C(=O)N1CCN(CC1)C(c1ccccc1)c1ccccc1)C
  • InChi: 1S/C23H25N5O3/c1-16-19(20(26-31-16)22(29)25-24)23(30)28-14-12-27(13-15-28)21(17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11,21H,12-15,24H2,1H3,(H,25,29)
  • InChiKey: WXUORVJUXOZZSW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[4-[di(phenyl)methyl]piperazine-1-carbonyl]-5-methyl-isoxazole-3-carbohydrazide
  • 4-[[4-[di(phenyl)methyl]-1-piperazinyl]-oxomethyl]-5-methyl-3-isoxazolecarbohydrazide
  • 4-[4-[di(phenyl)methyl]piperazin-1-yl]carbonyl-5-methyl-1,2-oxazole-3-carbohydrazide
  • 3G-901
  • 4-[(4-benzhydrylpiperazino)carbonyl]-5-methyl-3-isoxazolecarbohydrazide
  • MLS000720910
  • SMR000334259
  • Oprea1_306080

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0044 0.0082 0.0085
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0078 0.1733
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0071 0.0384
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0024 0.0023 0.0023
Trichomonas vaginalis glutaminase, putative 0.0311 0.0886 0.5671
Brugia malayi beta-lactamase 0.004 0.0071 0.0059
Mycobacterium tuberculosis Probable thioesterase TesA 0.0024 0.0024 0.0024
Loa Loa (eye worm) TAR-binding protein 0.0146 0.0391 0.0391
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0029 0.0039 0.004
Loa Loa (eye worm) beta-lactamase 0.004 0.0071 0.0071
Giardia lamblia Long chain fatty acid CoA ligase, putative 0.0042 0.0078 0.6049
Echinococcus granulosus microtubule associated protein 2 0.236 0.7047 0.7273
Plasmodium falciparum acyl-CoA synthetase 0.0042 0.0078 0.1733
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0078
Leishmania major 4-coumarate:coa ligase-like protein 0.0147 0.0393 0.0399
Brugia malayi hypothetical protein 0.0046 0.0088 0.0076
Mycobacterium tuberculosis Conserved protein 0.004 0.0071 0.0074
Trichomonas vaginalis AMP dependent ligase, putative 0.0042 0.0078 0.0429
Brugia malayi MH2 domain containing protein 0.012 0.031 0.0299
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0071
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0071 0.0074
Plasmodium falciparum LCCL domain-containing protein 0.0046 0.0088 0.1988
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0042 0.0078 0.0068
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0121 0.0113
Echinococcus granulosus transcription factor Dp 1 0.0088 0.0216 0.0211
Schistosoma mansoni hypothetical protein 0.0048 0.0094 0.0085
Trichomonas vaginalis antibiotic synthetase, putative 0.0147 0.0393 0.2474
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0147 0.0393 0.0394
Plasmodium falciparum acyl-CoA synthetase 0.0042 0.0078 0.1733
Echinococcus multilocularis GPCR, family 2 0.0036 0.006 0.005
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0218 0.0606 0.0614
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0071 0.0384
Brugia malayi glutaminase DH11.1 0.0311 0.0886 0.0875
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0087 0.009
Mycobacterium leprae Probable lipase LipE 0.004 0.0071 0.0065
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 0.0042 0.0078 0.0068
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0031 0.0044 0.0035
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0042 0.0078 0.1733
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0042 0.0078 0.0069
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0088 0.0078
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0071 0.0384
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0012 0.0012
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0068
Brugia malayi chromobox protein homolog 3 0.0044 0.0084 0.0073
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0042 0.0078 0.0068
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.015 0.0402 0.042
Trichomonas vaginalis AMP dependent CoA ligase, putative 0.0042 0.0078 0.0429
Loa Loa (eye worm) hypothetical protein 0.0062 0.0138 0.0138
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0189 0.115
Schistosoma mansoni hypothetical protein 0.0036 0.006 0.005
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0078 0.1663
Trichomonas vaginalis AMP dependent CoA ligase, putative 0.0042 0.0078 0.0429
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0147 0.0393 0.3681
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0054 0.0114 0.0105
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0042 0.0078 0.6049
Trypanosoma brucei acetyl-CoA synthetase, truncated 0.0042 0.0078 0.0638
Trichomonas vaginalis AMP dependent CoA ligase, putative 0.0042 0.0078 0.0429
Onchocerca volvulus 0.008 0.0192 0.0909
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0028 0.0036 0.0037
Brugia malayi beta-lactamase family protein 0.004 0.0071 0.0059
Loa Loa (eye worm) intermediate filament protein 0.0062 0.0138 0.0138
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0174 0.0475 0.0496
Trypanosoma brucei fatty acyl CoA synthetase, putative 0.0042 0.0078 0.0638
Leishmania major acetyl-CoA synthetase, putative 0.0147 0.0393 0.0399
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.0393 0.0385
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0055 0.0117 0.0105
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0071
Echinococcus granulosus long chain fatty acid transport protein 4 0.3238 0.9685 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.0393 0.0393
Loa Loa (eye worm) fatty acid synthase 0.0029 0.0037 0.0037
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0031 0.0044 0.0037
Onchocerca volvulus 0.0046 0.0088 0.0215
Echinococcus granulosus SAM and MBT domain containing protein 0.0054 0.0114 0.0105
Leishmania major hypothetical protein, conserved 0.0042 0.0078 0.0069
Onchocerca volvulus 0.0198 0.0546 0.3274
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0071 0.0074
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.3238 0.9685 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0147 0.0393 0.0411
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0121 0.0709
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0078 0.0069
Mycobacterium ulcerans hypothetical protein 0.0147 0.0393 0.0385
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0012 0.0012
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0023 0.0021 0.0013
Mycobacterium ulcerans Type I modular polyketide synthase 0.0029 0.0039 0.003
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 0.0042 0.0078 0.0068
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0147 0.0393 0.0402
Brugia malayi Pre-SET motif family protein 0.0468 0.1358 0.1348
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0069
Schistosoma mansoni hypothetical protein 0.0193 0.053 0.0536
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 0.0042 0.0078 0.0068
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0068
Plasmodium falciparum acyl-CoA synthetase 0.0042 0.0078 0.1733
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.3195 0.9558 1
Brugia malayi RNA recognition motif domain containing protein 0.0146 0.0391 0.0379
Brugia malayi Latrophilin receptor protein 2 0.0036 0.006 0.0048
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0071 0.0061
Schistosoma mansoni chromobox protein 0.0079 0.0189 0.0183
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0078
Echinococcus multilocularis Niemann Pick C1 protein 0.0165 0.0446 0.0449
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.0393 0.0385
Loa Loa (eye worm) heterochromatin protein 1 0.0079 0.0189 0.0189
Loa Loa (eye worm) hypothetical protein 0.0115 0.0297 0.0297
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0391 0.0391
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0078 0.1824
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0114 0.0105
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.0121 0.0114
Plasmodium falciparum acyl-CoA synthetase 0.0042 0.0078 0.1733
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0069
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2636 0.7876 0.813
Echinococcus multilocularis geminin 0.0193 0.053 0.0536
Echinococcus multilocularis expressed conserved protein 0.0108 0.0277 0.0274
Schistosoma mansoni intermediate filament proteins 0.0062 0.0138 0.013
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.006 0.0048
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0042 0.0078 0.0068
Onchocerca volvulus 0.0048 0.0096 0.0271
Plasmodium vivax long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0078 0.1733
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.0121 0.0113
Schistosoma mansoni myelin transcription factor 1 myt1 0.0062 0.0137 0.0129
Toxoplasma gondii hypothetical protein 0.0042 0.0078 0.1824
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0078
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0147 0.0393 0.0394
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0117 0.0109
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.3343 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0105 0.0096
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0117 0.0109
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.0393 0.0385
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0078 0.1663
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.008 0.0192 0.0186
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0078 0.1824
Mycobacterium tuberculosis Putative polyketide synthase Pks16 0.0042 0.0078 0.0081
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0084 0.047
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.0078 0.0072
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0023 0.0021 0.0013
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0029 0.0039 0.003
Mycobacterium tuberculosis Conserved protein 0.004 0.0071 0.0074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0078 0.0081
Brugia malayi Disco-interacting protein 2 homolog 0.0042 0.0078 0.0066
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 0.0042 0.0078 0.0068
Loa Loa (eye worm) hypothetical protein 0.0029 0.0038 0.0038
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0078 0.1663
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0042 0.0078 0.6049
Leishmania major 4-coumarate:coa ligase-like protein 0.0147 0.0393 0.0399
Onchocerca volvulus 0.004 0.0071 0.0104
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 0.0042 0.0078 0.0069
Loa Loa (eye worm) hypothetical protein 0.0091 0.0225 0.0225
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0078 0.1663
Schistosoma mansoni sex comb on midleg homolog 0.0054 0.0114 0.0105
Loa Loa (eye worm) mbt repeat family protein 0.0054 0.0114 0.0114
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0042 0.0078 0.0068
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0068
Entamoeba histolytica hypothetical protein 0.0041 0.0074 0.1559
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0051 0.0039
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.0663 0.0673
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0042 0.0078 0.0069
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0078 0.1663
Schistosoma mansoni hypothetical protein 0.0048 0.0094 0.0085
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0078 0.1663
Mycobacterium tuberculosis Conserved protein 0.004 0.0071 0.0074
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0121 0.0709
Schistosoma mansoni hypothetical protein 0.0036 0.006 0.005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0117 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0153 0.0145
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative 0.0042 0.0078 0.0429
Leishmania major 4-coumarate:coa ligase-like protein 0.0147 0.0393 0.0399
Mycobacterium ulcerans acyl-CoA synthetase 0.015 0.0402 0.0393
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.015 0.0402 0.0393
Loa Loa (eye worm) hypothetical protein 0.0062 0.0137 0.0137
Leishmania major fatty acyl CoA syntetase 1, putative 0.0042 0.0078 0.0069
Trypanosoma brucei fatty acyl CoA synthetase 2 0.0042 0.0078 0.0638
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0042 0.0078 0.0429
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0062 0.0137 0.0129
Echinococcus granulosus cytoplasmic intermediate filament protein 0.003 0.0041 0.003
Brugia malayi mbt repeat family protein 0.0054 0.0114 0.0102
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0029 0.0039 0.004
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0272 0.077 0.0783
Loa Loa (eye worm) MBCTL1 0.0062 0.0137 0.0137
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 0.0042 0.0078 0.0068
Mycobacterium ulcerans beta-lactamase 0.004 0.0071 0.0062
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0031 0.0044 0.0035
Loa Loa (eye worm) AMP-binding enzyme family protein 0.3343 1 1
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.1047 0.1085
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0068
Brugia malayi Niemann-Pick C1 protein precursor 0.0115 0.0298 0.0286
Loa Loa (eye worm) hypothetical protein 0.0067 0.0153 0.0153
Leishmania major acetyl-CoA synthetase, putative 0.0147 0.0393 0.0399
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 0.0042 0.0078 0.0069
Onchocerca volvulus 0.0533 0.1552 1
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0045 0.0087 0.0078
Toxoplasma gondii ABC1 family protein 0.004 0.0071 0.1646
Plasmodium vivax ATP-dependent acyl-CoA synthetase, putative 0.0042 0.0078 0.1733
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0078
Leishmania major hypothetical protein, unknown function 0.0042 0.0078 0.0069
Mycobacterium leprae Probable polyketide synthase Pks1 0.0031 0.0044 0.0037
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0174 0.0475 0.0475
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0042 0.0078 0.0068
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0071 0.0061
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0042 0.0078 0.0081
Mycobacterium leprae POSSIBLE PEPTIDE SYNTHETASE NRP (PEPTIDE SYNTHASE) 0.0042 0.0078 0.0072
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0147 0.0393 0.0402
Schistosoma mansoni hypothetical protein 0.0046 0.0088 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0071 0.0061
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.0121 0.0113
Echinococcus granulosus lamin dm0 0.0062 0.0138 0.013
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0152 0.0409 0.0411
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD11 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0078 0.0081
Echinococcus multilocularis Niemann Pick C1 protein 0.0115 0.0298 0.0295
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.0393 0.0385
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0071
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.072 0.0752
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0042 0.0078 0.0081
Loa Loa (eye worm) hypothetical protein 0.0036 0.006 0.006
Plasmodium vivax long-chain fatty acid CoA ligase, putative 0.0042 0.0078 0.1733
Plasmodium vivax acyl-CoA synthetase, putative 0.0042 0.0078 0.1733
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.031 0.031
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.0153 0.0145
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.047 0.048
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.0121 0.0113
Leishmania major pantothenate kinase subunit, putative 0.0046 0.009 0.0082
Schistosoma mansoni hypothetical protein 0.0036 0.006 0.005
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0071 0.0061
Brugia malayi hypothetical protein 0.0041 0.0074 0.0062
Plasmodium vivax SET domain protein, putative 0.0067 0.0153 0.3693
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.0121 0.0121
Mycobacterium ulcerans polyketide synthase Pks13 0.0044 0.0082 0.0073
Brugia malayi Pre-SET motif family protein 0.0067 0.0153 0.0141
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0391 0.0391
Schistosoma mansoni survival motor neuron protein 0.0048 0.0096 0.0087
Schistosoma mansoni patched 1 0.0049 0.01 0.0091
Loa Loa (eye worm) glutaminase 2 0.0311 0.0886 0.0886
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0147 0.0393 0.0411
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0121 0.0709
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0152 0.0409 0.0411
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0071 0.0074
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0147 0.0393 0.0385
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 0.0042 0.0078 0.0069
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0042 0.0078 0.0429
Loa Loa (eye worm) hypothetical protein 0.0061 0.0135 0.0135
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0071 0.0074
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0012 0.0003
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0042 0.0078 0.0072
Leishmania major long-chain-fatty-acid-CoA ligase, putative,acyl-CoA synthetase, putative,fatty acid thiokinase (long chain), putative 0.0042 0.0078 0.0069
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0105 0.0096
Loa Loa (eye worm) hypothetical protein 0.0237 0.0663 0.0663
Schistosoma mansoni lipoxygenase 0.0272 0.077 0.0783
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0042 0.0078 0.6049
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0078 0.1663
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0147 0.0393 0.9597
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0062 0.0137 0.0125
Trypanosoma brucei pantothenate kinase subunit, putative 0.0042 0.0078 0.0638
Onchocerca volvulus 0.0062 0.0138 0.0551
Trypanosoma brucei acyl-CoA synthetase, putative 0.0042 0.0078 0.0638
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0071 0.0384
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0468 0.1358 0.1358
Brugia malayi hypothetical protein 0.0042 0.0078 0.0066
Trichomonas vaginalis AMP dependent ligase, putative 0.0042 0.0078 0.0429
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0078 0.1824
Loa Loa (eye worm) hypothetical protein 0.0046 0.0088 0.0088
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.015 0.0402 0.0412
Trypanosoma cruzi fatty acyl CoA synthetase, putative 0.0042 0.0078 0.0068
Trichomonas vaginalis AMP dependent ligase, putative 0.0042 0.0078 0.0429
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 0.0042 0.0078 0.0068
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0057 0.0122 0.2974
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0012 0.5
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0096 0.0084
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.0013 0.0144
Echinococcus granulosus Niemann Pick C1 protein 0.0165 0.0446 0.0449
Echinococcus multilocularis lipoxygenase domain containing protein 0.0046 0.0088 0.0078
Loa Loa (eye worm) hypothetical protein 0.0147 0.0393 0.0393
Brugia malayi AMP-binding enzyme family protein 0.0147 0.0393 0.0382
Echinococcus multilocularis protein patched 0.0049 0.01 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0078 0.0069
Echinococcus multilocularis transcription factor Dp 1 0.0088 0.0216 0.0211
Toxoplasma gondii hypothetical protein 0.0059 0.0128 0.3114
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.006 0.005
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0139 0.0131
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 0.0042 0.0078 0.0068
Brugia malayi TAR-binding protein 0.0146 0.0391 0.0379
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.0078 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0147 0.0393 0.0393
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.047 0.4422
Echinococcus multilocularis AMP dependent ligase 0.0045 0.0087 0.0077
Trichomonas vaginalis set domain proteins, putative 0.0533 0.1552 1
Schistosoma mansoni lipoxygenase 0.019 0.0523 0.0528
Echinococcus multilocularis musashi 0.0062 0.0138 0.013
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 4 0.0042 0.0078 0.0068
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0105 0.0096
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0147 0.0393 0.0394
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0152 0.0409 1
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0095 0.0536
Brugia malayi mbt repeat family protein 0.0054 0.0114 0.0102
Onchocerca volvulus 0.0046 0.0088 0.0215
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.0121 0.2943
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.1047 1
Echinococcus granulosus Polycystic kidney disease protein 0.0046 0.0088 0.0078
Brugia malayi Heterochromatin protein 1 0.0079 0.0189 0.0177
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0071
Trypanosoma brucei fatty acyl CoA syntetase 1 0.0042 0.0078 0.0638
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0062 0.0137 0.0129
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.015 0.0402 0.0393
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0117 0.0109
Loa Loa (eye worm) hypothetical protein 0.0115 0.0298 0.0298
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.006 0.006
Entamoeba histolytica acyl-CoA synthetase, putative 0.0147 0.0393 0.9597
Loa Loa (eye worm) glutaminase 0.0311 0.0886 0.0886
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0042 0.0078 0.0081
Brugia malayi intermediate filament protein 0.0062 0.0138 0.0126
Loa Loa (eye worm) hypothetical protein 0.0147 0.0393 0.0393
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0078 0.0069
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.0121 0.0113
Echinococcus multilocularis SAM and MBT domain containing protein 0.0054 0.0114 0.0105
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0044 0.0082 0.0085
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.015 0.0402 0.042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0117 0.0109
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0147 0.0393 0.0411
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0069
Entamoeba histolytica hypothetical protein 0.0041 0.0074 0.1559
Echinococcus granulosus long chain fatty acid coenzyme A ligase 4 0.0042 0.0078 0.0068
Loa Loa (eye worm) hypothetical protein 0.0054 0.0114 0.0114
Plasmodium falciparum acyl-CoA synthetase 0.0042 0.0078 0.1733
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0071 0.0074
Echinococcus multilocularis disco interacting protein 2 0.0042 0.0078 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0153 0.0145
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0088 0.0078
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 0.0042 0.0078 0.0068
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0062 0.0138 0.0138
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0042 0.0078 0.0081
Schistosoma mansoni glutaminase 0.0311 0.0886 0.0903
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0147 0.0393 0.0411
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0147 0.0393 0.0394
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.0187 0.0176
Echinococcus multilocularis microtubule associated protein 2 0.236 0.7047 0.7273
Plasmodium falciparum acyl-CoA synthetase 0.0042 0.0078 0.1733
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0272 0.077 0.0783
Entamoeba histolytica acyl-CoA synthetase, putative 0.015 0.0402 0.982
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative 0.0042 0.0078 0.0068
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.0121 0.1054
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0071 0.0061
Entamoeba histolytica acyl-CoA synthetase, putative 0.0042 0.0078 0.1663
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0042 0.0078 0.0068
Entamoeba histolytica hypothetical protein 0.0041 0.0074 0.1559
Onchocerca volvulus 0.004 0.0071 0.0104
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0147 0.0393 0.0411
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0095 0.0536
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.0121 1
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0078 0.0066
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0152 0.0409 0.0411
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0068
Mycobacterium ulcerans polyketide synthase 0.0031 0.0044 0.0035
Echinococcus granulosus lamin 0.0062 0.0138 0.013
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0105 0.0093
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.015 0.0402 0.039
Onchocerca volvulus 0.0147 0.0393 0.2255
Echinococcus multilocularis Polycystic kidney disease protein 0.0046 0.0088 0.0078
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0029 0.0039 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0078 0.0069
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0042 0.0078 0.0068
Echinococcus multilocularis protein dispatched 1 0.0056 0.0121 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0391 0.0391
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0078 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.0393 0.0385
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0024 0.0024 0.0016
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0147 0.0393 0.0399
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0068
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0071 0.0572
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0528 0.0552
Schistosoma mansoni hypothetical protein 0.0048 0.0094 0.0085
Echinococcus granulosus intermediate filament protein 0.0062 0.0138 0.013
Mycobacterium ulcerans thioesterase 0.0024 0.0024 0.0015
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0147 0.0393 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0045 0.0217
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0078 0.0638
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1047 0.107
Schistosoma mansoni lamin 0.0062 0.0138 0.013
Echinococcus multilocularis RUN 0.0046 0.0088 0.0078
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.006 0.005
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0028 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.0035 0.0056 0.0056
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0147 0.0393 0.0385
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0147 0.0393 0.0394
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.006 0.005
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0045 0.0087 0.0078
Schistosoma mansoni hypothetical protein 0.0041 0.0074 0.0064
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0152 0.0409 0.0416
Loa Loa (eye worm) RNA binding protein 0.0146 0.0391 0.0391
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.0663 0.0673
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0078 0.0069
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0147 0.0393 0.0402
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0078
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0084 0.0193
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0042 0.0078 0.0072
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0068
Entamoeba histolytica acyl-coA synthetase, putative 0.0147 0.0393 0.9597
Loa Loa (eye worm) hypothetical protein 0.0147 0.0393 0.0393
Plasmodium falciparum acyl-CoA synthetase 0.0042 0.0078 0.1733
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0147 0.0393 0.0411
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative 0.0042 0.0078 0.0429
Trypanosoma cruzi fatty acyl CoA synthetase, putative 0.0042 0.0078 0.0068
Loa Loa (eye worm) hypothetical protein 0.0046 0.0088 0.0088
Toxoplasma gondii type I fatty acid synthase, putative 0.0073 0.0171 0.424
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.015 0.0402 0.0393
Brugia malayi AMP-binding enzyme family protein 0.0174 0.0475 0.0464
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.0121 0.0113
Onchocerca volvulus 0.015 0.0402 0.2314
Brugia malayi Intermediate filament tail domain containing protein 0.0062 0.0138 0.0126
Plasmodium falciparum acyl-CoA synthetase 0.0042 0.0078 0.1733
Echinococcus granulosus geminin 0.0193 0.053 0.0536
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0042 0.0078 0.5
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.01 0.01
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0147 0.0393 0.0385
Onchocerca volvulus 0.0042 0.0078 0.015
Trichomonas vaginalis chromobox protein, putative 0.0079 0.0189 0.115
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0042 0.0078 0.0081
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0078
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0071 0.0059
Loa Loa (eye worm) hypothetical protein 0.0049 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0044 0.0084 0.0084
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0147 0.0393 0.0385
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.047 0.0473
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0074 0.0064
Mycobacterium ulcerans lipase LipD 0.004 0.0071 0.0062
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.0393 0.0385
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0078 0.0066
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0069
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 0.0042 0.0078 0.0069
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0078
Mycobacterium leprae conserved hypothetical protein 0.004 0.0071 0.0065
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0031 0.0044 0.0045
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.0078 0.0072
Schistosoma mansoni hypothetical protein 0.0036 0.006 0.005
Toxoplasma gondii exonuclease III APE 0.002 0.0012 0.011
Echinococcus granulosus tar DNA binding protein 0.0146 0.0391 0.0391
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0147 0.0393 0.0394
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0147 0.0393 0.0385
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0071 0.0071
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0078 0.1824
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0152 0.0409 0.0411
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0068
Echinococcus multilocularis tar DNA binding protein 0.0146 0.0391 0.0391
Echinococcus granulosus expressed conserved protein 0.0108 0.0277 0.0274
Leishmania major fatty acid transporter protein-like protein 0.3195 0.9558 1
Brugia malayi beta-lactamase family protein 0.004 0.0071 0.0059
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.0297 0.0297
Mycobacterium ulcerans glutaminase 0.0311 0.0886 0.0878
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0117 0.0117
Brugia malayi hypothetical protein 0.0042 0.0078 0.0066
Trypanosoma brucei fatty acyl CoA synthetase, putative 0.0042 0.0078 0.0638
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative 0.0042 0.0078 0.0429
Loa Loa (eye worm) hypothetical protein 0.0029 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0042 0.0078 0.0068
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0023 0.0021 0.0013
Schistosoma mansoni rab6-interacting 0.0046 0.0088 0.0078
Schistosoma mansoni hypothetical protein 0.0334 0.0955 0.0975
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.01 0.0091
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0078 0.1663
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0031 0.0044 0.0045
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0071
Echinococcus granulosus histone acetyltransferase MYST2 0.0062 0.0137 0.0129
Plasmodium falciparum acyl-CoA synthetase 0.0042 0.0078 0.1733
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.0393 0.0385
Loa Loa (eye worm) hypothetical protein 0.0061 0.0133 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.01 0.0569
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.0297 0.0285
Entamoeba histolytica acyl-CoA synthetase, putative 0.0045 0.0087 0.1886
Brugia malayi CHE-14 protein 0.0049 0.01 0.0088
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0078 0.0069
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0152 0.0409 0.0398
Echinococcus granulosus AMP dependent ligase 0.0045 0.0087 0.0077
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0152 0.0409 0.3835
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.0393 0.0385
Mycobacterium leprae Putative polyketide synthetase Pks16 0.0042 0.0078 0.0072
Onchocerca volvulus 0.0062 0.0138 0.0551
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0029 0.0039 0.004
Brugia malayi AMP-binding enzyme family protein 0.0147 0.0393 0.0382
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.0153 0.0145
Giardia lamblia Long chain fatty acid CoA ligase 5 0.0042 0.0078 0.6049
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0042 0.0078 0.0429
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0031 0.0044 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0117 0.0109
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0117 0.0303 0.0301
Schistosoma mansoni chromobox protein 0.0079 0.0189 0.0183
Trypanosoma brucei fatty acyl CoA synthetase 4 0.0042 0.0078 0.0638
Echinococcus multilocularis chromobox protein 1 0.0079 0.0189 0.0183
Echinococcus multilocularis chromobox protein 1 0.0079 0.0189 0.0183
Trypanosoma cruzi AMP-binding enzyme, putative 0.0042 0.0078 0.0068
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0078 0.1663
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0042 0.0078 0.0081
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0078
Mycobacterium ulcerans Type I modular polyketide synthase 0.0029 0.0039 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0121 0.0113
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0042 0.0078 0.0068
Mycobacterium ulcerans Type I modular polyketide synthase 0.0029 0.0039 0.003
Plasmodium falciparum acyl-CoA synthetase 0.0042 0.0078 0.1733
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0078 0.1663
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0065 0.0145 0.0138
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0067 0.0153 0.3762
Schistosoma mansoni rab6-interacting 0.0046 0.0088 0.0078
Echinococcus granulosus chromobox protein 1 0.0079 0.0189 0.0183
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0117 0.0109
Echinococcus multilocularis polycomb protein SCMH1 0.0054 0.0114 0.0105
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.01 0.0091
Giardia lamblia Long chain fatty acid CoA ligase 4 0.0042 0.0078 0.6049
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0054 0.0114 0.039
Echinococcus multilocularis histone acetyltransferase MYST2 0.0062 0.0137 0.0129
Treponema pallidum long-chain-fatty-acid--CoA ligase 0.0042 0.0078 1
Plasmodium falciparum acyl-CoA synthetase 0.0042 0.0078 0.1733
Mycobacterium ulcerans hypothetical protein 0.0192 0.0528 0.052
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0087 0.0082
Plasmodium vivax acetyl-CoA synthetase, putative 0.0147 0.0393 1
Schistosoma mansoni lamin 0.0062 0.0138 0.013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.006 0.005
Trypanosoma brucei fatty acyl CoA synthetase 3 0.0042 0.0078 0.0638
Echinococcus granulosus Protein patched homolog 1 0.0049 0.01 0.0091
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0146 0.0391 0.0391
Echinococcus granulosus GPCR family 2 0.0036 0.006 0.005
Plasmodium vivax multidomain scavenger receptor, putative 0.0046 0.0088 0.1988
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0042 0.0078 0.0429
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0147 0.0393 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0071 0.0074
Onchocerca volvulus 0.0174 0.0475 0.2802
Brugia malayi cDNA sequence BC018371 0.0042 0.0078 0.0066
Plasmodium vivax hypothetical protein, conserved 0.004 0.0071 0.1554
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0078
Echinococcus granulosus polycomb protein SCMH1 0.0054 0.0114 0.0105
Giardia lamblia Hypothetical protein 0.0042 0.0078 0.6049
Onchocerca volvulus 0.0147 0.0393 0.2255
Loa Loa (eye worm) oxidoreductase 0.0147 0.0393 0.0393
Echinococcus multilocularis acyl coenzyme A synthetase family 0.0042 0.0078 0.0068
Mycobacterium ulcerans thioesterase TesA 0.0024 0.0024 0.0015
Plasmodium falciparum acyl-CoA synthetase 0.0042 0.0078 0.1733
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.031 0.031
Brugia malayi hypothetical protein 0.0237 0.0663 0.0652
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.0078 0.0072
Toxoplasma gondii propionate-CoA ligase 0.0147 0.0393 1
Onchocerca volvulus 0.004 0.0071 0.0104
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0147 0.0393 0.0385
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0078 0.0069
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0078 0.1663
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0042 0.0078 0.1663
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0021 0.0014 0.0014
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0071 0.0062
Onchocerca volvulus 0.0054 0.0114 0.039
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0147 0.0393 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0029 0.0039 0.0031
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0042 0.0078 0.0069
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0029 0.0039 0.0027
Schistosoma mansoni AMP dependent ligase 0.0042 0.0078 0.0068
Schistosoma mansoni polycystin 1-related 0.0046 0.0088 0.0078
Brugia malayi Doublecortin family protein 0.0046 0.0088 0.0076
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0071 0.0074
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.003 0.0041 0.003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0117 0.0105
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.0297 0.0285
Schistosoma mansoni hypothetical protein 0.0048 0.0094 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0153 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0084 0.047
Schistosoma mansoni microtubule-associated protein tau 0.236 0.7047 0.7273
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0105 0.0266 0.0277
Trypanosoma brucei protein kinase, putative 0.0057 0.0121 0.1054
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0147 0.0393 0.0382
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.015 0.0402 0.042
Echinococcus granulosus acyl coenzyme A synthetase family 0.0042 0.0078 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.0393 0.0385
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.0121 0.0113
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.015 0.0402 0.042
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0042 0.0078 0.0081
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0078
Echinococcus granulosus RUN 0.0046 0.0088 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0078 0.0066
Mycobacterium ulcerans polyketide synthase 0.0029 0.0039 0.003
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0042 0.0078 0.0429
Echinococcus granulosus lipoxygenase domain containing protein 0.0046 0.0088 0.0078
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0042 0.0078 0.0068
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.015 0.0402 0.0393
Brugia malayi MAP kinase sur-1 0.0057 0.0121 0.0109
Mycobacterium tuberculosis Probable fatty acyl-AMP ligase MbtM 0.0042 0.0078 0.0081
Brugia malayi AMP-binding enzyme family protein 0.0147 0.0393 0.0382
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0147 0.0393 0.0411
Schistosoma mansoni hypothetical protein 0.0048 0.0096 0.0087
Leishmania major hypothetical protein, conserved 0.004 0.0071 0.0062
Leishmania major long chain fatty Acyl CoA synthetase, putative 0.0042 0.0078 0.0069
Trichomonas vaginalis antibiotic synthetase, putative 0.0147 0.0393 0.2474
Brugia malayi AMP-binding enzyme family protein 0.0147 0.0393 0.0382
Onchocerca volvulus Fatty acid synthase homolog 0.0053 0.0109 0.0356
Loa Loa (eye worm) doublecortin family protein 0.0046 0.0088 0.0088
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0152 0.0409 0.0409
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.3195 0.9558 1
Entamoeba histolytica hypothetical protein 0.0042 0.0078 0.1663
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0074 0.0064
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.0121 0.0113
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0071 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.0078 0.0078
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.3238 0.9685 1
Mycobacterium ulcerans hypothetical protein 0.004 0.0071 0.0062
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 0.0042 0.0078 0.0068
Schistosoma mansoni acetyl-CoA synthetase 0.0147 0.0393 0.0394
Entamoeba histolytica hypothetical protein 0.0041 0.0074 0.1559
Echinococcus multilocularis lamin dm0 0.0062 0.0138 0.013
Echinococcus multilocularis lamin 0.0062 0.0138 0.013
Echinococcus multilocularis long chain fatty acid transport protein 4 0.3238 0.9685 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0147 0.0393 0.0385
Schistosoma mansoni loxhd1 0.0046 0.0088 0.0078
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0147 0.0393 0.3681
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.0121 0.0709
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0042 0.0078 0.0068
Mycobacterium ulcerans acetyl-CoA synthetase 0.0147 0.0393 0.0385
Leishmania major fatty acyl CoA synthetase 2, putative 0.0042 0.0078 0.0069
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0046 0.009 0.0081
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0152 0.0409 0.0411
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0218 0.0606 0.0614
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.0121 0.0114
Mycobacterium leprae Polyketide synthase Pks13 0.0044 0.0082 0.0077
Echinococcus granulosus chromobox protein 1 0.0079 0.0189 0.0183
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0041
Trypanosoma cruzi fatty acyl CoA syntetase 1, putative 0.0042 0.0078 0.0068
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0095 0.026
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0147 0.0393 0.0385
Brugia malayi hypothetical protein 0.0046 0.0088 0.0076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0074 0.0064
Echinococcus granulosus Niemann Pick C1 protein 0.0115 0.0298 0.0295
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0105 0.0899
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0067 0.0153 0.0145
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0147 0.0393 0.0411
Echinococcus granulosus disco interacting protein 2 0.0042 0.0078 0.0068
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0042 0.0078 0.0429
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1047 0.107
Brugia malayi RNA binding protein 0.0146 0.0391 0.0379
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0071 0.0384
Trichomonas vaginalis esterase, putative 0.004 0.0071 0.0384
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0115 0.0298 0.7193
Trypanosoma brucei Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 5) (LACS 5), putative 0.0042 0.0078 0.0638
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0042 0.0078 0.0081
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0071 0.0061
Schistosoma mansoni long-chain-fatty-acid--CoA ligase 0.0042 0.0078 0.0068
Trichomonas vaginalis AMP dependent ligase/synthetase, putative 0.0042 0.0078 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0045 0.0217
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0391 0.0391
Schistosoma mansoni hypothetical protein 0.0079 0.0187 0.0181
Schistosoma mansoni FFA transport protein 0.3238 0.9685 1
Mycobacterium ulcerans putative fatty-acid--CoA ligase 0.0042 0.0078 0.0069
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0147 0.0393 0.0402
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0042 0.0078 0.0069
Loa Loa (eye worm) hypothetical protein 0.0079 0.0187 0.0187
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0031 0.0044 0.0045
Schistosoma mansoni hypothetical protein 0.0193 0.053 0.0536
Brugia malayi AMP-binding enzyme family protein 0.0147 0.0393 0.0382

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5221 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5774 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.