Detailed information for compound 1255610

Basic information

Technical information
  • TDR Targets ID: 1255610
  • Name: 2-(3,4-dimethyl-7-oxo-2-phenylpyrazolo[4,3-d] pyridazin-6-yl)-N-[(5-methylfuran-2-yl)methyl ]butanamide
  • MW: 419.476 | Formula: C23H25N5O3
  • H donors: 1 H acceptors: 3 LogP: 3.17 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(n1nc(C)c2c(c1=O)nn(c2C)c1ccccc1)C(=O)NCc1ccc(o1)C
  • InChi: 1S/C23H25N5O3/c1-5-19(22(29)24-13-18-12-11-14(2)31-18)28-23(30)21-20(15(3)25-28)16(4)27(26-21)17-9-7-6-8-10-17/h6-12,19H,5,13H2,1-4H3,(H,24,29)
  • InChiKey: YOKLQUOAFGTKDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3,4-dimethyl-7-oxo-2-phenyl-pyrazolo[4,3-d]pyridazin-6-yl)-N-[(5-methyl-2-furyl)methyl]butanamide
  • 2-(3,4-dimethyl-7-oxo-2-phenyl-6-pyrazolo[4,3-d]pyridazinyl)-N-[(5-methyl-2-furyl)methyl]butanamide
  • 2-(7-keto-3,4-dimethyl-2-phenyl-pyrazolo[4,3-d]pyridazin-6-yl)-N-[(5-methyl-2-furyl)methyl]butyramide
  • 2-(3,4-dimethyl-7-oxo-2-phenyl-pyrazolo[4,3-d]pyridazin-6-yl)-N-[(5-methylfuran-2-yl)methyl]butanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.0273 0.5213
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0203 0.0901 0.0901
Echinococcus multilocularis zinc finger protein 0.0029 0.006 0.006
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.0021 0.0021
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0065 0.0065
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0065 0.0061
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0035 0.0077
Plasmodium falciparum glutathione reductase 0.0022 0.0027 0.063
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0065 0.0252
Loa Loa (eye worm) hypothetical protein 0.0042 0.012 0.0577
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0135 0.8052
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0101 0.0315
Brugia malayi TAZ zinc finger family protein 0.0109 0.0444 0.2168
Echinococcus granulosus geminin 0.0205 0.0907 0.0907
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0161 0.0156
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.0021 0.0021
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0101 0.0101
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0154 0.0154
Brugia malayi Pre-SET motif family protein 0.0203 0.09 0.4472
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0027 0.0032
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0029 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0048 0.0151 0.0729
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0273 0.1767
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0273 0.0925
Treponema pallidum ATP-dependent DNA helicase 0.0025 0.0039 0.0044
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0033 0.0079 0.0108
Schistosoma mansoni protein kinase 0.0076 0.0284 0.028
Leishmania major trypanothione reductase 0.0048 0.0151 0.0911
Onchocerca volvulus Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial homolog 0.0022 0.0023 0.0038
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0299
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.01 0.0311
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0135 0.0435
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0076 0.0284 0.1401
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0065 0.0065
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0065 0.0065
Trypanosoma brucei protein kinase, putative 0.0052 0.017 0.1096
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.017 0.0829
Schistosoma mansoni lipoxygenase 0.002 0.0015 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0065 0.0065
Echinococcus granulosus RUN 0.002 0.0015 0.0015
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0027 0.063
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0154 0.2732
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.01 0.0311
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0036 0.0092 0.0092
Echinococcus multilocularis caspase 3 0.0074 0.0275 0.0275
Echinococcus granulosus CREB binding protein 0.0109 0.0444 0.0444
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0181 0.088
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.01 0.0311
Leishmania major hypothetical protein, conserved 0.0028 0.0054 0.0225
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0047 0.0143 0.8597
Loa Loa (eye worm) hypothetical protein 0.0074 0.0274 0.1351
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0027 0.0032
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0158 0.0158
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.01 0.0311
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.0496 0.0753
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0199 0.0199
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.017 0.017
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0151 0.0734
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0151 0.0911
Schistosoma mansoni microtubule-associated protein tau 0.2087 1 1
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0036 0.0092 0.0092
Plasmodium falciparum thioredoxin reductase 0.0048 0.0151 0.716
Trypanosoma cruzi metacaspase, putative 0.0045 0.0135 0.0796
Plasmodium falciparum thioredoxin reductase 0.0022 0.0027 0.063
Schistosoma mansoni DNA polymerase eta 0.0029 0.0057 0.0053
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0189 0.0189
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0314 0.1437 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0262 0.0262
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0293 0.1335 0.1958
Trypanosoma cruzi succinate dehydrogenase, putative 0.0033 0.0076 0.0378
Brugia malayi ImpB/MucB/SamB family protein 0.0029 0.0057 0.0213
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0012 0.0012
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0036 0.0092 0.0491
Loa Loa (eye worm) succinate-ubiquinone oxidoreductase 0.0022 0.0023 0.0086
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0027 0.0095
Brugia malayi Inositol-1 0.0073 0.0273 0.13
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0048 0.0044
Giardia lamblia Fructose-bisphosphate aldolase 0.06 0.2818 1
Echinococcus granulosus caspase 0.0119 0.0491 0.0491
Echinococcus granulosus hypothetical protein 0.0028 0.0055 0.0055
Echinococcus granulosus FTZ F1 alpha 0.003 0.0065 0.0065
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.01 0.0311
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.0273 0.0273
Entamoeba histolytica recQ family helicase, putative 0.0052 0.0169 0.0554
Trypanosoma cruzi succinate dehydrogenase iron-sulfur subunit 0.0033 0.0076 0.0378
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0027 0.0032
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.002 0.0027
Schistosoma mansoni rab6-interacting 0.002 0.0015 0.0011
Plasmodium vivax flavoprotein subunit of succinate dehydrogenase, putative 0.0022 0.0023 0.0498
Echinococcus multilocularis dna polymerase kappa 0.0081 0.0312 0.0312
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0293 0.1335 0.1977
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0047 0.0143 0.018
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0047 0.0143 0.0464
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0101 0.0315
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0065 0.0252
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0092 0.0282
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0115 0.0364
Leishmania major succinate dehydrogenase, putative 0.0033 0.0076 0.0378
Schistosoma mansoni blooms syndrome DNA helicase 0.0037 0.0098 0.0093
Onchocerca volvulus 0.0098 0.0392 0.1906
Loa Loa (eye worm) hypothetical protein 0.005 0.0158 0.0769
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0027 0.009
Mycobacterium leprae Probable succinate dehydrogenase (iron-sulfur protein subunit) SdhB (SUCCINIC DEHYDROGENASE) (FUMARATE REDUCTASE) (FUMARATE DEHY 0.0028 0.0054 0.0048
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0052 0.0169 0.1084
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0414 0.1428
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.09 0.4499
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0078 0.0444
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0027 0.009
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0131 0.0131
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0101 0.5786
Brugia malayi Bromodomain containing protein 0.0087 0.0339 0.1633
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.0273 0.0396
Toxoplasma gondii thioredoxin reductase 0.0048 0.0151 0.2687
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0065 0.0252
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0235 0.0318
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.1409 0.6725 1
Trypanosoma cruzi metacaspase, putative 0.0045 0.0135 0.0796
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0199 0.125
Mycobacterium tuberculosis Conserved hypothetical protein 0.0029 0.0057 0.0078
Loa Loa (eye worm) hypothetical protein 0.0049 0.0156 0.0754
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0081 0.0312 0.1066
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0154 0.0154
Schistosoma mansoni coup transcription factor 0.003 0.0065 0.0061
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0121 0.0175
Brugia malayi hypothetical protein 0.0028 0.0056 0.0204
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0307 0.1404 0.4957
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0273 0.1767
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.0626 0.0626
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.0273 0.0925
Echinococcus multilocularis tumor protein p63 0.0342 0.1572 0.1572
Schistosoma mansoni hypothetical protein 0.0042 0.0123 0.0119
Echinococcus multilocularis RUN 0.002 0.0015 0.0015
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0189 0.0189
Mycobacterium ulcerans succinate dehydrogenase flavoprotein subunit 0.0022 0.0023 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0151 0.0146
Trichomonas vaginalis STE family protein kinase 0.0076 0.0284 0.0967
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0065 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0065 0.0252
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.06 0.2818 1
Plasmodium vivax glutathione reductase, putative 0.0048 0.0151 0.9144
Schistosoma mansoni inositol monophosphatase 0.0073 0.0273 0.0268
Leishmania major metacaspase, putative 0.0045 0.0135 0.0796
Plasmodium vivax metacaspase 1, putative 0.0045 0.0135 0.8052
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0414 0.0414
Schistosoma mansoni alpha glucosidase 0.0038 0.01 0.0096
Brugia malayi glutathione reductase 0.0048 0.0151 0.0688
Brugia malayi mbt repeat family protein 0.005 0.0158 0.0724
Loa Loa (eye worm) glutathione reductase 0.0048 0.0151 0.0734
Schistosoma mansoni rab6-interacting 0.002 0.0015 0.0011
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0015 0.0015
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0076 0.0284 0.1359
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2818 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0216 0.1061
Brugia malayi CHE-14 protein 0.0044 0.0131 0.0586
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.0312 0.2093
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.05 0.0735
Echinococcus multilocularis microtubule associated protein 2 0.2087 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0135 0.0435
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2818 1
Schistosoma mansoni caspase-3 (C14 family) 0.0119 0.0491 0.0487
Loa Loa (eye worm) inositol-1 0.0073 0.0273 0.1343
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.06 0.2818 1
Mycobacterium tuberculosis Probable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogena 0.0022 0.0023 0.0024
Brugia malayi Pre-SET motif family protein 0.003 0.0065 0.0251
Echinococcus multilocularis caspase 8 0.0045 0.0135 0.0135
Plasmodium falciparum flavoprotein subunit of succinate dehydrogenase 0.0022 0.0023 0.039
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0273 0.1815
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0065 0.0252
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.01 0.055
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0232 0.0228
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0036 0.0092 0.0282
Onchocerca volvulus 0.005 0.0158 0.0724
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0092 0.0282
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.05 0.0735
Echinococcus multilocularis neuropeptide receptor A26 0.0481 0.2244 0.2244
Schistosoma mansoni bromodomain containing protein 0.0075 0.028 0.0275
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.0738 0.365
Brugia malayi PHD-finger family protein 0.0035 0.0087 0.0361
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0192 0.0187
Trichomonas vaginalis STE family protein kinase 0.0076 0.0284 0.0967
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0312 0.2047
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0414 0.0414
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) iron sulfur 0.0051 0.0164 0.0164
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0065 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0312 0.2093
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0312 0.2047
Mycobacterium tuberculosis Probable oxidoreductase 0.0109 0.0443 0.0673
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0099 0.0099
Echinococcus multilocularis cpg binding protein 0.0064 0.0229 0.0229
Brugia malayi jmjC domain containing protein 0.0065 0.0232 0.1097
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0101 0.0557
Schistosoma mansoni CREB-binding protein 2 0.0109 0.0444 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0135 0.0435
Onchocerca volvulus 0.005 0.0161 0.0735
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0065 0.0252
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0027 0.0027
Trypanosoma brucei DNA polymerase IV, putative 0.0081 0.0312 0.2093
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0039 0.035
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0049 0.0156 0.2772
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.05 0.05
Loa Loa (eye worm) tumor suppressor 0.0335 0.1536 0.7691
Schistosoma mansoni DNA helicase recq5 0.0049 0.0156 0.0151
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.0718 0.1096
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0065 0.0065
Echinococcus multilocularis succinate dehydrogenase iron sulfur protein 0.0028 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.031 0.1413 0.141
Schistosoma mansoni hypothetical protein 0.0205 0.0907 0.0903
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0143 0.021
Trypanosoma brucei trypanothione reductase 0.0048 0.0151 0.0964
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0099 0.0395 0.0598
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0033 0.0079 0.1185
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0015 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2818 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0414 0.2052
Schistosoma mansoni hypothetical protein 0.0042 0.0123 0.0119
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.01 0.0311
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0232 0.0228
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0065 0.0061
Mycobacterium tuberculosis Probable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase) 0.0022 0.0023 0.0024
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0135 0.0796
Brugia malayi nuclear hormone receptor 0.003 0.0065 0.0252
Echinococcus granulosus succinate dehydrogenase ubiquinone iron sulfur 0.0051 0.0164 0.0164
Loa Loa (eye worm) acetyltransferase 0.0155 0.0668 0.333
Schistosoma mansoni hypothetical protein 0.0042 0.0123 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0135 0.0435
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0047 0.0143 0.0464
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0199 0.0297
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0101 0.0146
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0052 0.0169 0.1032
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0065 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0065 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0065 0.0252
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0047 0.0143 0.0853
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0065 0.0065
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0299
Echinococcus granulosus protein quaking 0.0028 0.0055 0.0055
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) iron sulfur 0.0033 0.0076 0.0076
Schistosoma mansoni terminal deoxycytidyl transferase 0.0029 0.0057 0.0053
Trypanosoma brucei metacaspase MCA2 0.0045 0.0135 0.0849
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0101 0.4531
Brugia malayi succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0022 0.0023 0.0038
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0027 0.0032
Schistosoma mansoni ap endonuclease 0.0038 0.0101 0.0097
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0076 0.0284 0.185
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.01 0.055
Trichomonas vaginalis STE family protein kinase 0.0076 0.0284 0.0967
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0004 0.0004
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0192 0.0892
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0047 0.0143 0.0853
Brugia malayi Temporarily assigned gene name protein 44 0.0028 0.0056 0.0204
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0135 0.0435
Plasmodium falciparum glutathione reductase 0.0048 0.0151 0.716
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.012 0.012
Mycobacterium tuberculosis Probable succinate dehydrogenase (iron-sulphur protein subunit) SdhB (succinic dehydrogenase) (fumarate reductase) (fumarate deh 0.0028 0.0054 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0049
Loa Loa (eye worm) hypothetical protein 0.004 0.0112 0.0534
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.01 0.0311
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0312 0.2047
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.012 0.012
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.0738 0.0738
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0065 0.0299
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0192 0.0192
Schistosoma mansoni alpha-glucosidase 0.0146 0.0624 0.062
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.0668 0.3297
Mycobacterium ulcerans succinate dehydrogenase iron-sulfur subunit 0.0028 0.0054 0.0071
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0637 0.4346
Brugia malayi Bromodomain containing protein 0.0045 0.0138 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0135 0.0435
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0065 0.0061
Brugia malayi succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0022 0.0023 0.0038
Echinococcus granulosus dna polymerase eta 0.0029 0.0057 0.0057
Leishmania major eukaryotic translation initiation factor-like 0.0036 0.0092 0.0491
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0027 0.0032
Echinococcus granulosus cpg binding protein 0.0064 0.0229 0.0229
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.017 0.1044
Brugia malayi translation initiation factor 4E 0.0036 0.0092 0.0389
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0036 0.0092 0.1449
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.1437 1
Schistosoma mansoni lozenge 0.0054 0.0179 0.0175
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0101 0.3152
Loa Loa (eye worm) hypothetical protein 0.0044 0.0131 0.0632
Trichomonas vaginalis DNA polymerase eta, putative 0.0081 0.0312 0.1066
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0216 0.1421
Echinococcus multilocularis geminin 0.0205 0.0907 0.0907
Onchocerca volvulus 0.0042 0.012 0.0531
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.05 0.076
Trypanosoma brucei Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0.0022 0.0023 0.0058
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0154 0.0501
Loa Loa (eye worm) hypothetical protein 0.005 0.0161 0.078
Echinococcus multilocularis bloom syndrome protein 0.0062 0.0219 0.0219
Brugia malayi Bloom's syndrome protein homolog 0.0062 0.0219 0.1027
Plasmodium vivax iron-sulfur subunit of succinate dehydrogenase, putative 0.0051 0.0164 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0099 0.0395 0.0598
Schistosoma mansoni caspase-7 (C14 family) 0.0119 0.0491 0.0487
Echinococcus granulosus dual specificity mitogen activated protein 0.0076 0.0284 0.0284
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0049 0.0156 0.0754
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0299
Leishmania major NADH dehydrogenase, putative 0.0033 0.0079 0.0402
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0022 0.0027 0.003
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0035 0.0089 0.4979
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0036 0.0092 0.0088
Trypanosoma brucei metacaspase MCA3 0.0045 0.0135 0.0849
Trypanosoma brucei metacaspase 0.0045 0.0135 0.0849
Leishmania major DNA polymerase eta, putative 0.0029 0.0057 0.0246
Schistosoma mansoni succinate dehydrogenase 0.0022 0.0023 0.0018
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0299
Brugia malayi hypothetical protein 0.023 0.1027 0.5112
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0206 0.0206
Trypanosoma brucei unspecified product 0.0068 0.0249 0.1649
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0312 0.2093
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0115 0.5252
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0059 0.0205 1
Loa Loa (eye worm) translation initiation factor 4E 0.0036 0.0092 0.0435
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0101 0.0557
Leishmania major mitochondrial DNA polymerase beta 0.0314 0.1437 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0048 0.015 0.0727
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0312 0.2093
Leishmania major eukaryotic translation initiation factor-like protein 0.0036 0.0092 0.0491
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0036 0.0092 0.0491
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0027 0.0804
Wolbachia endosymbiont of Brugia malayi succinate dehydrogenase iron-sulfur subunit 0.0051 0.0164 0.5665
Giardia lamblia DINP protein human, muc B family 0.0042 0.0121 0.0383
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0199 0.0199
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0151 0.0223
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0312 0.2093
Chlamydia trachomatis succinate dehydrogenase iron sulfur subunit 0.0028 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0152 0.0734
Schistosoma mansoni hypothetical protein 0.0028 0.0055 0.0051
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0047 0.0143 0.0464
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.017 0.308
Brugia malayi MAP kinase sur-1 0.0052 0.017 0.0784
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0307 0.1404 0.4957
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0145 0.0655
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0036 0.0092 0.0491
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.017 0.1044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0027 0.0032
Onchocerca volvulus 0.003 0.0065 0.0251
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0232 0.114
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0036 0.0092 0.0547
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0027 0.063
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0029 0.0057 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2818 1
Schistosoma mansoni cpg binding protein 0.0059 0.0204 0.0199
Giardia lamblia Kinase, STE STE20 0.0076 0.0284 0.0967
Onchocerca volvulus 0.003 0.0065 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0065 0.0252
Schistosoma mansoni alpha-glucosidase 0.0146 0.0624 0.062
Schistosoma mansoni cpg binding protein 0.0064 0.0229 0.0225
Schistosoma mansoni hypothetical protein 0.0042 0.0123 0.0119
Brugia malayi nuclear receptor NHR-88 0.003 0.0065 0.0252
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0027 0.0032
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.0273 0.0273
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.0273 1
Brugia malayi hypothetical protein 0.0042 0.012 0.0531
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.05 0.0496
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0135 0.0796
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.01 0.0311
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0299
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.017 0.056
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0314 0.1437 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0131 0.0131
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0135 0.0435
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0135 0.0435
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.01 0.0477
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0151 0.9144
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.0273 0.1767
Mycobacterium ulcerans succinate dehydrogenase flavoprotein subunit 0.0022 0.0023 0.0024
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0027 0.005
Onchocerca volvulus 0.0059 0.0204 0.0952
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0135 0.2348
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0065 0.0252
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0151 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0312 0.2093
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0158 0.0158
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0047 0.0143 0.0139
Trypanosoma brucei metacaspase 5, putative 0.0045 0.0135 0.0849
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0047 0.0143 0.0693
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0076 0.0284 0.185
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0065 0.0065
Schistosoma mansoni thyroid hormone receptor 0.003 0.0065 0.0061
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0421 0.0417
Echinococcus multilocularis protein patched 0.0044 0.0131 0.0131
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.05 0.9966
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0158 0.0158
Echinococcus multilocularis protein quaking 0.0028 0.0055 0.0055
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0101 0.0101
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.017 0.017
Schistosoma mansoni lipoxygenase 0.0056 0.0189 0.0185
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0235 0.0352
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0192 0.0192
Toxoplasma gondii hypothetical protein 0.0051 0.0164 0.2941
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.017 0.1096
Loa Loa (eye worm) hypothetical protein 0.043 0.1995 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0065 0.0881
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.017 0.056
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.017 0.017
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.017 0.056
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.01 0.055
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0049 0.0156 0.7374
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0135 0.2348
Echinococcus multilocularis caspase 0.0119 0.0491 0.0491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0065 0.0299
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0047 0.0143 0.0143
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0135 0.2348
Giardia lamblia NADH oxidase lateral transfer candidate 0.0022 0.0027 0.005
Loa Loa (eye worm) hypothetical protein 0.023 0.1027 0.5135
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0022 0.0025 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2818 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0027 0.0032
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0158 0.0154
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0027 0.0032
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0047 0.0143 0.6732
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0049 0.0156 0.0156
Brugia malayi ImpB/MucB/SamB family protein 0.0029 0.0057 0.0213
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0049 0.0156 0.0709
Schistosoma mansoni hypothetical protein 0.0205 0.0907 0.0903
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0065 0.0061
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0027 0.0183
Schistosoma mansoni blooms syndrome DNA helicase 0.0025 0.0039 0.0035
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.01 0.01
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0027 0.0183
Brugia malayi steroid hormone receptor 0.003 0.0065 0.0252
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0192 0.0192
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0034 0.0144
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.017 0.056
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.0668 0.0668
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0115 0.0364
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0109 0.0443 0.0628
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0151 0.0146
Echinococcus multilocularis protein dispatched 1 0.005 0.0161 0.0161
Mycobacterium ulcerans hypothetical protein 0.0166 0.0718 0.1059
Echinococcus granulosus dnaJ subfamily B 0.084 0.3977 0.3977
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0065 0.0061
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0027 0.0061
Brugia malayi tumor suppressor. 0.0335 0.1536 0.768
Schistosoma mansoni ap endonuclease 0.0038 0.0101 0.0097
Schistosoma mansoni hypothetical protein 0.0042 0.012 0.0116
Echinococcus multilocularis dual specificity mitogen activated protein 0.0076 0.0284 0.0284
Plasmodium falciparum metacaspase-like protein 0.0045 0.0135 0.6305
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0154 0.9287
Loa Loa (eye worm) hypothetical protein 0.0025 0.0039 0.0171
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.017 0.1044
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0299
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0022 0.0085
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1027 0.1027
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0047 0.0145 0.014
Trypanosoma brucei DNA polymerase eta, putative 0.0029 0.0057 0.0303
Schistosoma mansoni hypothetical protein 0.0028 0.0055 0.0051
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0049 0.0156 0.0156
Trichomonas vaginalis DNA helicase recq, putative 0.0052 0.0169 0.0554
Trypanosoma brucei succinate dehydrogenase iron-sulfur subunit, putative 0.0033 0.0076 0.0434
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0048 0.0048
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0087 0.0337 0.1665
Loa Loa (eye worm) hypothetical protein 0.0057 0.0192 0.0936
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0022 0.0027 0.003
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0109 0.0444 0.044
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0078 0.0444
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0065 0.0252
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0158 0.0724
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0027 0.0804
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0027 0.0095
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0293 0.1335 0.2046
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0092 0.0282
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.0668 0.0664
Echinococcus granulosus expressed conserved protein 0.0096 0.0384 0.0384
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0049 0.0156 0.0709
Giardia lamblia Sgs1 DNA helicase, putative 0.0049 0.0156 0.0508
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.01 0.0311
Echinococcus granulosus zinc finger protein 0.0029 0.006 0.006
Echinococcus granulosus caspase 8 0.0045 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0299
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0216 0.1421
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0065 0.0065
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.0626 0.0626
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0027 0.0023
Entamoeba histolytica recQ family DNA helicase 0.0025 0.0039 0.0094
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0048 0.0048
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.0273 0.0925
Trypanosoma cruzi metacaspase, putative 0.0045 0.0135 0.0796
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0033 0.0079 0.3375
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0047 0.0143 0.0143
Schistosoma mansoni survival motor neuron protein 0.0047 0.0145 0.014
Trypanosoma cruzi NADH dehydrogenase, putative 0.0033 0.0079 0.0402
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0149 0.0637 0.4379
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0039 0.0119
Loa Loa (eye worm) doublecortin family protein 0.002 0.0015 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0121 0.0747
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0065 0.0252
Echinococcus multilocularis CREB binding protein 0.0077 0.0289 0.0289
Toxoplasma gondii exonuclease III APE 0.0038 0.0101 0.1643
Echinococcus granulosus neuropeptide s receptor 0.0481 0.2244 0.2244
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0045 0.0135 0.0652
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1027 0.1027
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0065 0.0061
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0119 0.0491 0.0491
Trichomonas vaginalis DNA helicase recq1, putative 0.0062 0.0219 0.0732
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2818 1
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0065 0.0299
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0065 0.0065
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0065 0.0299
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0065 0.0252
Mycobacterium tuberculosis Probable fumarate reductase [iron-sulfur subunit] FrdB (fumarate dehydrogenase) (fumaric hydrogenase) 0.0028 0.0054 0.0073
Echinococcus granulosus succinate dehydrogenase (ubiquinone) iron sulfur 0.0051 0.0164 0.0164
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0312 0.2093
Trypanosoma brucei succinate dehydrogenase iron-sulfur subunit 0.0028 0.0054 0.0282
Loa Loa (eye worm) hypothetical protein 0.0054 0.0179 0.0872
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.003 0.0065 0.0299
Schistosoma mansoni hypothetical protein 0.084 0.3977 0.3974
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0027 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0135 0.0435
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0065 0.0065
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0022 0.0027 0.003
Schistosoma mansoni nuclear hormone receptor 0.003 0.0065 0.0061
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.05 0.0496
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0119 0.0491 0.0491
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0065 0.0299
Echinococcus granulosus caspase 3 0.0074 0.0275 0.0275
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.017 0.056
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0414 0.2013
Loa Loa (eye worm) CBP-B 0.0077 0.0293 0.1445
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0015 0.0015
Echinococcus granulosus CREB binding protein 0.007 0.0254 0.0254
Trypanosoma brucei DNA polymerase IV, putative 0.0068 0.0249 0.1649
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0078 0.0444
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.017 0.1044
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0131 0.0632
Brugia malayi polk-prov protein 0.0062 0.0216 0.1017
Loa Loa (eye worm) runx1 0.0054 0.0179 0.0873
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0047 0.0143 0.2517
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0045 0.0135 0.0606
Onchocerca volvulus Cell death protein 3 homolog 0.0087 0.0337 0.1624
Trichomonas vaginalis DNA helicase recq, putative 0.0062 0.0219 0.0732
Loa Loa (eye worm) hypothetical protein 0.043 0.1995 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0029 0.0057 0.0246
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0047 0.0143 0.0203
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.01 0.1624
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0036 0.0092 0.0282
Brugia malayi mbt repeat family protein 0.005 0.0158 0.0724
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0158 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0065 0.0299
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0065 0.0252
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0065 0.0252
Schistosoma mansoni inositol monophosphatase 0.0073 0.0273 0.0268
Echinococcus multilocularis Protein lozenge 0.0054 0.0179 0.0179
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0012 0.0012
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0132 0.0775
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0312 0.2093
Loa Loa (eye worm) MBCTL1 0.0057 0.0192 0.0936
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0029 0.0057 0.0261
Onchocerca volvulus 0.0047 0.0145 0.0655
Plasmodium vivax SET domain protein, putative 0.003 0.0065 0.3333
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.0312 0.0455
Echinococcus granulosus caspase 2 0.0087 0.0337 0.0337
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0065 0.0065
Brugia malayi Cell death protein 3 precursor 0.0087 0.0337 0.1624
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0045 0.0135 0.0131
Schistosoma mansoni DNA helicase recq1 0.0049 0.0156 0.0151
Echinococcus granulosus succinate dehydrogenase ubiquinone iron sulfur 0.0023 0.0028 0.0028
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0029 0.0057 0.0053
Loa Loa (eye worm) hypothetical protein 0.0053 0.0176 0.0857
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0049
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0131 0.0131
Schistosoma mansoni jumonji domain containing protein 0.006 0.0206 0.0202
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0034 0.0085 0.1297
Echinococcus granulosus dna polymerase kappa 0.0081 0.0312 0.0312
Echinococcus multilocularis caspase 2 0.0087 0.0337 0.0337
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0204 0.0996
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2818 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0502 1
Schistosoma mansoni hypothetical protein 0.002 0.0015 0.0011
Loa Loa (eye worm) RecQ helicase 0.0062 0.0219 0.1071
Loa Loa (eye worm) hypothetical protein 0.0029 0.0057 0.0261
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.05 0.0735
Trypanosoma cruzi NADH dehydrogenase, putative 0.0033 0.0079 0.0402
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0158 0.0154
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0022 0.0027 0.1431
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0179 0.1105
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0199 0.0287
Loa Loa (eye worm) succinate dehydrogenase iron-sulfur protein 0.0051 0.0164 0.0798
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0101 0.0141
Schistosoma mansoni succinate dehydrogenase iron-sulfur protein 0.0051 0.0164 0.016
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0101 0.0612
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.01 0.0311
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0109 0.0443 0.0673
Mycobacterium tuberculosis Probable fumarate reductase [flavoprotein subunit] FrdA (fumarate dehydrogenase) (fumaric hydrogenase) 0.0022 0.0023 0.0024
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0101 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0312 0.2093
Schistosoma mansoni succinate dehydrogenase iron-sulfur protein 0.0028 0.0054 0.005
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.05 0.05
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.01 0.0311
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0203 0.0901 0.0901
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.0738 0.3681
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.017 0.1044
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0022 0.0027 0.0031
Brugia malayi Thioredoxin reductase 0.0048 0.0151 0.0688
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0065 0.0065
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0151 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0135 0.0435
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0738 0.0738
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1035 0.3644
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0065 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0065 0.006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0101 0.0482
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0206 0.0206
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0738 0.0738
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0049 0.0156 0.0156
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.0273 0.0925
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.017 0.1044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0065 0.0252
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0206 0.0206
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0047 0.0143 0.021
Echinococcus multilocularis dnaJ subfamily B 0.084 0.3977 0.3977
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.06 0.2818 1
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.1363 0.65 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0027 0.0032
Echinococcus multilocularis succinate dehydrogenase (ubiquinone) 0.0022 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0131 0.0421
Brugia malayi ecdysteroid receptor 0.003 0.0065 0.0252
Schistosoma mansoni thyroid hormone receptor 0.003 0.0065 0.0061
Onchocerca volvulus 0.043 0.1995 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0312 0.2093
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0132 0.0775
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0065 0.0299
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0121 0.0693
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0065 0.0065
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0199 0.0931
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0027 0.009
Echinococcus granulosus tumor protein p63 0.0342 0.1572 0.1572
Brugia malayi CXXC zinc finger family protein 0.0059 0.0204 0.0952
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.0496 0.0706
Treponema pallidum fructose-bisphosphate aldolase 0.06 0.2818 1
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.017 0.0166
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0052 0.0169 0.1032
Mycobacterium tuberculosis Probable reductase 0.0099 0.0395 0.0598
Plasmodium falciparum metacaspase 1 0.0045 0.0135 0.6305
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.0528 0.0524
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0049 0.0156 0.2772
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.0496 0.0753
Loa Loa (eye worm) hypothetical protein 0.0028 0.0056 0.0252
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0036 0.0092 0.0282
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0101 0.0436
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0132 0.0775
Schistosoma mansoni caspase-7 (C14 family) 0.0087 0.0337 0.0332
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0004 0.0004
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.05 0.3378
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0065 0.0252
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0025 0.0039 0.0119
Entamoeba histolytica deoxycytidyl transferase, putative 0.0029 0.0057 0.0158
Schistosoma mansoni loxhd1 0.002 0.0015 0.0011
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0047 0.0143 0.0906
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0065 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0065 0.0252
Schistosoma mansoni hypothetical protein 0.0021 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0038 0.0102 0.0487
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0101 0.0315
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0135 0.0435
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0012 0.0033
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0047 0.0143 0.0464
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0049 0.0156 0.0156
Mycobacterium tuberculosis Probable dehydrogenase 0.0099 0.0395 0.0598
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0076 0.0284 0.1897
Schistosoma mansoni zinc finger protein 0.0029 0.006 0.0055
Echinococcus multilocularis neuropeptide s receptor 0.0481 0.2244 0.2244
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0027 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0135 0.0435
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0101 0.0266
Trypanosoma cruzi succinate dehydrogenase iron-sulfur subunit 0.0028 0.0054 0.0225
Onchocerca volvulus Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial homolog 0.0022 0.0023 0.0038
Mycobacterium leprae Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) 0.1409 0.6725 1
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0158 0.0769
Schistosoma mansoni polycystin 1-related 0.002 0.0015 0.0011
Onchocerca volvulus 0.0231 0.1035 0.5153
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0033 0.0079 0.431
Trypanosoma cruzi metacaspase, putative 0.0045 0.0135 0.0796
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0024 0.0035 0.1317
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0199 0.0195
Trypanosoma cruzi DNA polymerase kappa, putative 0.0081 0.0312 0.2047
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0027 0.0032
Trypanosoma brucei glucosidase, putative 0.0038 0.01 0.0605
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0027 0.0027
Echinococcus multilocularis dna polymerase eta 0.0029 0.0057 0.0057
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0047 0.0143 0.0647
Schistosoma mansoni patched 1 0.0044 0.0131 0.0127
Toxoplasma gondii succinate dehydrogenase [ubiquinone] iron-sulfur protein 0.0051 0.0164 0.2953
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0099 0.0099
Mycobacterium ulcerans DNA polymerase IV 0.0081 0.0312 0.0455
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0065 0.0065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0065 0.006
Trypanosoma brucei NADH dehydrogenase 0.0033 0.0079 0.0457
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0135 0.0435
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0154 0.0154
Schistosoma mansoni cpg binding protein 0.0064 0.0229 0.0225
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0154 0.0501
Leishmania major DNA polymerase kappa, putative 0.0042 0.0121 0.0693
Echinococcus granulosus bloom syndrome protein 0.0062 0.0219 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0065 0.0299
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.01 0.01
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0027 0.009
Brugia malayi succinate dehydrogenase [ubiquinone] iron-sulfur protein, mitochondrial 0.0051 0.0164 0.0753
Plasmodium falciparum iron-sulfur subunit of succinate dehydrogenase 0.0051 0.0164 0.783
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0135 0.0435
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0149 0.0637 0.4346
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0033 0.0079 0.1185
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0135 0.0435
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0192 0.0192
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0065 0.0065
Brugia malayi jmjC domain containing protein 0.006 0.0206 0.0966
Echinococcus granulosus neuropeptide receptor A26 0.0481 0.2244 0.2244
Brugia malayi hypothetical protein 0.043 0.1995 1
Echinococcus multilocularis expressed conserved protein 0.0096 0.0384 0.0384
Trypanosoma brucei Metacaspase-4 0.0045 0.0135 0.0849
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0109 0.0443 0.0673
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0199 0.0287
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0047 0.0143 0.0853
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0101 0.0557
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0158 0.0158
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.01 0.0431
Echinococcus granulosus succinate dehydrogenase ubiquinone 0.0022 0.0023 0.0023
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0132 0.0828
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0154 0.2732
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.017 0.017
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0232 0.0232

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.1582 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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