Detailed information for compound 1274975

Basic information

Technical information
  • TDR Targets ID: 1274975
  • Name: N-[2-[6-[(4-fluorophenyl)methylamino]-[1,2,4] triazolo[5,4-f]pyridazin-3-yl]ethyl]benzamide
  • MW: 390.414 | Formula: C21H19FN6O
  • H donors: 2 H acceptors: 4 LogP: 2.92 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)CNc1ccc2n(n1)c(CCNC(=O)c1ccccc1)nn2
  • InChi: 1S/C21H19FN6O/c22-17-8-6-15(7-9-17)14-24-18-10-11-19-25-26-20(28(19)27-18)12-13-23-21(29)16-4-2-1-3-5-16/h1-11H,12-14H2,(H,23,29)(H,24,27)
  • InChiKey: UACNYTBMQARPGT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[6-[(4-fluorobenzyl)amino]-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]ethyl]benzamide
  • SMR000324046
  • ZINC04358572
  • MLS000685295

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0177 0.1102 0.2656
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0584 0.139
Schistosoma mansoni transcription factor LCR-F1 0.0165 0.102 0.0993
Loa Loa (eye worm) hypothetical protein 0.0212 0.1335 0.313
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.012 0.071 0.1094
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0145 0.0115
Trichomonas vaginalis set domain proteins, putative 0.0262 0.1674 1
Schistosoma mansoni protein kinase 0.0054 0.0264 0.0235
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0013
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0033 0.012 0.0144
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0257 0.0228
Leishmania major hypothetical protein, conserved 0.0033 0.0119 0.0397
Onchocerca volvulus 0.0025 0.0068 0.0089
Schistosoma mansoni cpg binding protein 0.003 0.0101 0.0071
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0036 0.0009
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.1023 0.4421
Schistosoma mansoni hypothetical protein 0.0021 0.0042 0.0012
Echinococcus multilocularis Sterile alpha motif type 0.0025 0.0068 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0342 0.0313
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0036 0.0005
Brugia malayi PHD-finger family protein 0.0021 0.0042 0.0069
Echinococcus granulosus geminin 0.0529 0.3491 0.5572
Trypanosoma brucei mitochondrial DNA polymerase beta 0.035 0.2276 1
Echinococcus granulosus lysine specific demethylase 5A 0.0099 0.0567 0.0865
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0028
Brugia malayi ecdysteroid receptor 0.002 0.0036 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0125 0.0095
Brugia malayi Liprin-alpha 2 0.0025 0.0068 0.0133
Schistosoma mansoni ran 0.0022 0.0048 0.0018
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0053 0.0257 0.0545
Brugia malayi RNA binding protein 0.0065 0.0342 0.0801
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0065 0.0341 0.0312
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0232 0.0898
Schistosoma mansoni cpg binding protein 0.0051 0.0245 0.0216
Trypanosoma cruzi ISWI complex protein 0.0033 0.0119 0.0397
Echinococcus granulosus FTZ F1 alpha 0.002 0.0036 0.0009
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.0738 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0305 0.1223
Echinococcus granulosus sphingomyelin synthase protein 1 0.0025 0.0068 0.0061
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0325 0.4074
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0147 0.0877
Trypanosoma cruzi Kinesin-13 5, putative 0.0025 0.0068 0.0169
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0028
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0147 0.052
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0061 0.0313 0.0678
Schistosoma mansoni hypothetical protein 0.0044 0.0197 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0036 0.0013
Plasmodium vivax importin-beta 2, putative 0.0059 0.03 0.9534
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0048 0.0217
Schistosoma mansoni cpg binding protein 0.0051 0.0245 0.0216
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0934 0.6241 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0036 0.0054
Brugia malayi hypothetical protein 0.0025 0.0068 0.0133
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0934 0.6241 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0113 0.0133
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0232 0.0898
Echinococcus granulosus polycomb protein SCMH1 0.0367 0.239 0.38
Brugia malayi PHD-finger family protein 0.0021 0.0042 0.0069
Onchocerca volvulus 0.0025 0.0068 0.0089
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0342 0.0748
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0036 0.0005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0061 0.0313 0.2855
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0021 0.0128
Echinococcus granulosus SAM and MBT domain containing protein 0.0486 0.3197 0.5099
Echinococcus granulosus histone acetyltransferase myst3 0.0046 0.0213 0.0294
Toxoplasma gondii hypothetical protein 0.0056 0.0281 0.3435
Echinococcus granulosus Sterile alpha motif SAM 0.0025 0.0068 0.0061
Brugia malayi Bromodomain containing protein 0.0082 0.0453 0.1072
Loa Loa (eye worm) hypothetical protein 0.0082 0.0454 0.1017
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0033 0.012 0.009
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0025 0.0068 0.0061
Schistosoma mansoni hypothetical protein 0.0053 0.0257 0.0228
Echinococcus multilocularis uro adherence factor A 0.0021 0.0042 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0036 0.0054
Loa Loa (eye worm) hypothetical protein 0.0032 0.0114 0.0202
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0054 0.0264 0.0377
Loa Loa (eye worm) inositol-1 0.0037 0.0147 0.028
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.03 0.1202
Schistosoma mansoni hypothetical protein 0.0427 0.2795 0.2774
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0036 0.0009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0042 0.0019
Schistosoma mansoni hypothetical protein 0.0032 0.0114 0.0084
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.0327 0.2115 0.3356
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0036 0.0009
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0033 0.012 0.0144
Echinococcus multilocularis histone acetyltransferase myst3 0.0046 0.0213 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0068 0.0407
Schistosoma mansoni thyroid hormone receptor 0.002 0.0036 0.0005
Schistosoma mansoni hypothetical protein 0.0021 0.0042 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0042 0.025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0373 0.0343
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0114 0.0136
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0147 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0036 0.0013
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0061 0.0313 0.1258
Loa Loa (eye worm) F/Y-rich family protein 0.0021 0.0042 0.0028
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0621 0.4113 0.9798
Schistosoma mansoni myst-related protein 0.0023 0.0054 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0013
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0313 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.008 0.0118
Schistosoma mansoni bromodomain containing protein 0.0026 0.0076 0.0046
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0025 0.0068 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0203 0.0173
Giardia lamblia Kinase, STE STE20 0.0054 0.0264 0.8283
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0232 0.0898
Echinococcus granulosus importin subunit beta 1 0.0059 0.03 0.0435
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.011
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0054 0.0264 0.0377
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0114 0.0246
Brugia malayi PHD-finger family protein 0.007 0.0376 0.0883
Toxoplasma gondii hypothetical protein 0.0026 0.0071 0.0415
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0061 0.0313 0.0455
Mycobacterium tuberculosis Conserved hypothetical protein 0.0184 0.115 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0025 0.007 0.0063
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0337 0.0308
Brugia malayi serine/threonine-protein kinase PAK 7 0.0621 0.4113 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0224 0.1338
Toxoplasma gondii exonuclease III APE 0.0061 0.0313 0.3893
Echinococcus multilocularis polycomb protein SCMH1 0.0367 0.239 0.38
Entamoeba histolytica hypothetical protein 0.0023 0.0054 0.0243
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0013
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0036 0.0009
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0077 0.1307
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0028
Echinococcus granulosus snurportin 1 0.0633 0.4198 0.671
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0032 0.0117 0.1074
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0091
Trypanosoma cruzi Kinesin-13 5, putative 0.0025 0.0068 0.0169
Brugia malayi hypothetical protein 0.0165 0.102 0.2455
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0077 0.1307
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0025 0.0068 0.0091
Onchocerca volvulus 0.0045 0.0203 0.0459
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0147 0.0877
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0028
Brugia malayi RNA, U transporter 1 0.0169 0.1043 0.2511
Trichomonas vaginalis cgi-62, putative 0.0025 0.0068 0.0407
Schistosoma mansoni inositol monophosphatase 0.0037 0.0147 0.0117
Echinococcus granulosus liprin alpha 2 0.0025 0.0068 0.0061
Brugia malayi PHD-finger family protein 0.0021 0.0042 0.0069
Echinococcus multilocularis chromobox protein 2 0.0197 0.1233 0.1936
Echinococcus granulosus TAF3 RNA polymerase II TATA box binding protein 0.0021 0.0042 0.0019
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0036 0.0005
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.012 0.071 0.1094
Loa Loa (eye worm) AIDA-1b 0.0025 0.0068 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0028
Schistosoma mansoni zinc finger protein 0.0021 0.0042 0.0012
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0048 0.0028
Echinococcus multilocularis Zinc finger, DBF type 0.0021 0.0042 0.0019
Schistosoma mansoni intermediate filament proteins 0.0027 0.008 0.005
Echinococcus multilocularis liprin alpha 2 0.0025 0.0068 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0021 0.0128
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0091
Echinococcus multilocularis musashi 0.0027 0.008 0.0079
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0042 0.0028
Schistosoma mansoni hypothetical protein 0.0021 0.0042 0.0012
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0077 0.1307
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0147 0.052
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0021 0.0128
Loa Loa (eye worm) tnks protein 0.0025 0.0068 0.0091
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0114 0.0136
Echinococcus granulosus pdz domain containing protein 0.0025 0.0068 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0021 0.0128
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0077 0.0209
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0145 0.0185
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0021 0.0128
Schistosoma mansoni dpf3 0.0021 0.0042 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0036 0.0005
Echinococcus multilocularis importin subunit beta 1 0.0059 0.03 0.0435
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0224 0.0863
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0036 0.0013
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0091
Loa Loa (eye worm) intermediate filament protein 0.0027 0.008 0.0118
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0486 0.3197 0.3176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0036 0.0013
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0036 0.0009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0061 0.0313 0.2523
Trichomonas vaginalis STE family protein kinase 0.0054 0.0264 0.1578
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0054 0.0264 0.0377
Onchocerca volvulus 0.0021 0.0042 0.0017
Schistosoma mansoni hypothetical protein 0.0633 0.4198 0.418
Schistosoma mansoni ran 0.0022 0.0048 0.0018
Brugia malayi mbt repeat family protein 0.0378 0.2463 0.5975
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0738 0.071
Schistosoma mansoni myelin transcription factor 1 myt1 0.0212 0.1335 0.1308
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0036 0.0009
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0101 0.0169
Giardia lamblia Giardia trophozoite antigen GTA-1 0.0025 0.0068 0.1344
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0567 0.0539
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0028
Brugia malayi bicaudal-C 0.0025 0.0068 0.0133
Entamoeba histolytica hypothetical protein 0.0048 0.0224 0.1958
Treponema pallidum exodeoxyribonuclease (exoA) 0.0061 0.0313 0.5
Echinococcus multilocularis PAK box P21 Rho binding 0.0054 0.0264 0.0377
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0114 0.0136
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0036 0.0009
Brugia malayi PHD-finger family protein 0.0021 0.0042 0.0069
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0077 0.0419 0.0626
Schistosoma mansoni hypothetical protein 0.0032 0.0114 0.0084
Echinococcus granulosus phd finger protein 10 0.0021 0.0042 0.0019
Trypanosoma cruzi Ring finger domain/PHD-finger, putative 0.0021 0.0042 0.0052
Schistosoma mansoni jumonji domain containing protein 0.0025 0.007 0.0039
Loa Loa (eye worm) hypothetical protein 0.0059 0.03 0.0648
Schistosoma mansoni hypothetical protein 0.0033 0.0119 0.0089
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.0738 0.1139
Brugia malayi hypothetical protein 0.0026 0.0077 0.0156
Trypanosoma cruzi Ring finger domain/PHD-finger, putative 0.0021 0.0042 0.0052
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.003 0.0041
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0212 0.1335 0.3222
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0028
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0054 0.0264 0.0377
Brugia malayi hypothetical protein 0.0021 0.0042 0.0069
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0061 0.0313 0.0455
Schistosoma mansoni hypothetical protein 0.0069 0.0366 0.0337
Echinococcus granulosus PHD finger protein 14 0.0021 0.0042 0.0019
Schistosoma mansoni fyve-containing 0.0021 0.0042 0.0012
Brugia malayi intermediate filament protein 0.0027 0.008 0.0161
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0342 0.0801
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0224 0.1338
Echinococcus granulosus tar DNA binding protein 0.0065 0.0342 0.0502
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0042 0.025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0061 0.0313 0.1258
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.03 0.1202
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0077 0.0209
Echinococcus granulosus zinc finger protein 0.0059 0.0298 0.0431
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0028
Plasmodium falciparum zinc finger protein, putative 0.0023 0.0054 0.0458
Echinococcus multilocularis Sterile alpha motif SAM 0.0025 0.0068 0.0061
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0036 0.0054
Entamoeba histolytica p21-activated kinase 0.0054 0.0264 0.2365
Echinococcus multilocularis phd finger protein 12 0.0021 0.0042 0.0019
Trichomonas vaginalis STE family protein kinase 0.0054 0.0264 0.1578
Brugia malayi Pre-SET motif family protein 0.0034 0.0125 0.0272
Brugia malayi Sphingomyelin synthase-related 1 0.0025 0.0068 0.0133
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0313 0.1868
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0036 0.0054
Brugia malayi Shank2E 0.0025 0.0068 0.0133
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0048 0.0217
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0021 0.0128
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0013
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0091
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0025 0.0068 0.0061
Brugia malayi coiled-coil like protein 1 0.0025 0.0068 0.0133
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0036 0.0009
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0166 0.1023 0.4421
Echinococcus multilocularis TAF3 RNA polymerase II, TATA box binding protein 0.0021 0.0042 0.0019
Brugia malayi mbt repeat family protein 0.0558 0.3687 0.896
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0738 0.071
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0147 0.0188
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0342 0.0313
Trypanosoma brucei ISWI complex protein 0.0033 0.0119 0.0397
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0036 0.0009
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0212 0.1335 0.21
Echinococcus multilocularis lysine specific demethylase 5A 0.0077 0.0423 0.0632
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0091
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.0113
Echinococcus multilocularis dnaJ subfamily B 0.0427 0.2795 0.4452
Schistosoma mansoni protein kinase 0.0053 0.0257 0.0228
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0036 0.0054
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0048 0.0619
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0025 0.0068 0.0407
Entamoeba histolytica Ran family GTPase 0.0022 0.0048 0.0177
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0061 0.0313 1
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0077 0.0509
Schistosoma mansoni DNAj-like protein 0.0025 0.0068 0.0038
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0036 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0036 0.0009
Schistosoma mansoni nuclear hormone receptor 0.002 0.0036 0.0005
Echinococcus multilocularis PHD and RING finger domain containing protein 1 0.0021 0.0042 0.0019
Leishmania major mitochondrial DNA polymerase beta 0.035 0.2276 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0145 0.0185
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0125 0.0153
Schistosoma mansoni lamin 0.0027 0.008 0.005
Onchocerca volvulus 0.0023 0.0054 0.0052
Brugia malayi P21-Rho-binding domain containing protein 0.0053 0.0257 0.0594
Echinococcus granulosus uro adherence factor A 0.0021 0.0042 0.0019
Trypanosoma brucei SAM domain (Sterile alpha motif), putative 0.0025 0.0068 0.0169
Brugia malayi Inositol-1 0.0037 0.0147 0.0325
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0077 0.0419 0.0626
Schistosoma mansoni thyroid hormone receptor 0.002 0.0036 0.0005
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0147 0.1042
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0121 0.5
Loa Loa (eye worm) MBCTL1 0.0212 0.1335 0.313
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0114 0.0246
Echinococcus granulosus liprin alpha 2 0.0025 0.0068 0.0061
Schistosoma mansoni requim req/dpf2 0.0021 0.0042 0.0012
Entamoeba histolytica hypothetical protein 0.0053 0.0257 0.2293
Loa Loa (eye worm) CHromoDomain protein family member 0.0033 0.012 0.0215
Entamoeba histolytica hypothetical protein 0.0165 0.102 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.023 0.1459 0.3429
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.003 0.018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1177 0.1151
Schistosoma mansoni hypothetical protein 0.0053 0.0257 0.0228
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.0738 0.6319
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0042 0.025
Schistosoma mansoni sex comb on midleg homolog 0.0367 0.239 0.2367
Entamoeba histolytica protein kinase, putative 0.0054 0.0264 0.2365
Echinococcus granulosus lamin dm0 0.0027 0.008 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0036 0.0054
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0147 0.052
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0044 0.0195 0.22
Schistosoma mansoni polyhomeotic 0.0025 0.0068 0.0038
Loa Loa (eye worm) hypothetical protein 0.0101 0.0584 0.1328
Schistosoma mansoni phd finger protein 0.0046 0.0213 0.0183
Schistosoma mansoni bromodomain containing protein 0.0152 0.0932 0.0905
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0048 0.0084
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0036 0.0009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0114 0.0202
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0366 0.0861
Schistosoma mansoni spingomyelin synthetase-related 0.0025 0.0068 0.0038
Echinococcus granulosus cpg binding protein 0.0051 0.0245 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0036 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1177 0.1847
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0021 0.0128
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0166 0.1023 0.4421
Brugia malayi Bromodomain associated family protein 0.0021 0.0042 0.0069
Schistosoma mansoni tyrosine kinase 0.0053 0.0257 0.0228
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0025 0.0068 0.0038
Loa Loa (eye worm) hypothetical protein 0.007 0.0373 0.0822
Brugia malayi Pre-SET motif family protein 0.023 0.1459 0.3526
Trichomonas vaginalis inhibitor of growth, putative 0.0021 0.0042 0.025
Entamoeba histolytica protein kinase, putative 0.0054 0.0264 0.2365
Brugia malayi nuclear receptor NHR-88 0.002 0.0036 0.0054
Echinococcus multilocularis GPCR, family 2 0.0032 0.0114 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0042 0.025
Echinococcus multilocularis pdz domain containing protein 0.0025 0.0068 0.0061
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0091
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0028
Schistosoma mansoni importin beta-1 0.0059 0.03 0.0271
Echinococcus granulosus histone acetyltransferase myst4 0.0021 0.0042 0.0019
Trypanosoma brucei Ring finger domain/PHD-finger, putative 0.0021 0.0042 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0342 0.0313
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0061 0.0313 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0114 0.0136
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0036 0.0005
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0048 0.0083
Schistosoma mansoni zinc finger protein 0.0033 0.0119 0.0089
Echinococcus granulosus lysine specific demethylase 5B 0.0021 0.0042 0.0019
Onchocerca volvulus 0.0025 0.0068 0.0089
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.03 0.3711
Schistosoma mansoni hypothetical protein 0.0021 0.0042 0.0012
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0054 0.0264 0.0377
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0749 0.1726
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0165 0.102 0.1593
Schistosoma mansoni hypothetical protein 0.0025 0.0068 0.0038
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0145 0.088 0.1369
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0048 0.0078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1177 0.1847
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0036 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0013
Schistosoma mansoni Protein aveugle 0.0025 0.0068 0.0038
Loa Loa (eye worm) hypothetical protein 0.0027 0.008 0.0118
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0053 0.0257 0.0228
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0048 0.0078
Schistosoma mansoni zinc finger protein 0.0021 0.0042 0.0012
Trichomonas vaginalis ap endonuclease, putative 0.0061 0.0313 0.1868
Trichomonas vaginalis STE family protein kinase 0.0054 0.0264 0.1578
Entamoeba histolytica hypothetical protein 0.0165 0.102 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0232 0.0898
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0077 0.0209
Brugia malayi CXXC zinc finger family protein 0.003 0.0101 0.0213
Toxoplasma gondii PLU-1 family protein 0.0044 0.0195 0.2201
Schistosoma mansoni myst histone acetyltransferase 0.0021 0.0042 0.0012
Brugia malayi hypothetical protein 0.0025 0.0068 0.0133
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0065 0.0341 0.0501
Brugia malayi steroid hormone receptor 0.002 0.0036 0.0054
Entamoeba histolytica hypothetical protein 0.0165 0.102 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0036 0.0054
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0212 0.1335 0.21
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0738 0.6319
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0558 0.3687 1
Brugia malayi jmjC domain containing protein 0.0142 0.0865 0.2077
Loa Loa (eye worm) hypothetical protein 0.0053 0.0257 0.0545
Schistosoma mansoni hypothetical protein 0.0327 0.2115 0.2091
Schistosoma mansoni hypothetical protein 0.0032 0.0114 0.0084
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0568 0.3753 0.5995
Onchocerca volvulus 0.0021 0.0042 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0036 0.0054
Schistosoma mansoni SET domain protein 0.0023 0.0054 0.0024
Loa Loa (eye worm) jmjC domain-containing protein 0.0142 0.0865 0.2003
Plasmodium vivax SET domain protein, putative 0.0034 0.0125 0.3076
Plasmodium falciparum importin beta, putative 0.0059 0.03 0.9534
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0738 0.6319
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0189 0.1177 0.2753
Echinococcus multilocularis lysine specific demethylase 5B 0.0021 0.0042 0.0019
Echinococcus multilocularis histone acetyltransferase MYST2 0.0212 0.1335 0.21
Brugia malayi Hypothetical C28H8.9 in chromosome III 0.0021 0.0042 0.0069
Echinococcus multilocularis PAK box P21 Rho binding 0.0053 0.0257 0.0365
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0584 0.139
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0036 0.0054
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0061 0.0313 0.1258
Schistosoma mansoni hypothetical protein 0.0529 0.3491 0.3471
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0036 0.0054
Giardia lamblia Kinesin-13 0.0025 0.0068 0.1344
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0342 0.0313
Mycobacterium ulcerans hypothetical protein 0.0184 0.115 1
Entamoeba histolytica hypothetical protein 0.0053 0.0257 0.2293
Echinococcus multilocularis lamin 0.0027 0.008 0.0079
Loa Loa (eye worm) RNA binding protein 0.0065 0.0342 0.0748
Loa Loa (eye worm) hypothetical protein 0.0108 0.0633 0.1446
Schistosoma mansoni hypothetical protein 0.0032 0.0114 0.0084
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0036 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1177 0.1151
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0568 0.3753 0.5995
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0036 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0042 0.025
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0025 0.0068 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0036 0.0054
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0154 0.0296
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0224 0.1338
Schistosoma mansoni inositol monophosphatase 0.0037 0.0147 0.0117
Echinococcus granulosus dnaJ subfamily B 0.0427 0.2795 0.4452
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0036 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0189 0.1177 0.1151
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0061 0.0313 0.2523
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0036 0.0054
Brugia malayi Importin beta-1 subunit 0.0059 0.03 0.0699
Brugia malayi nuclear hormone receptor 0.002 0.0036 0.0054
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0036 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0036 0.0009
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0053 0.0257 0.0365
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0738 0.6319
Onchocerca volvulus 0.0025 0.0068 0.0089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0036 0.0009
Leishmania major hypothetical protein, conserved 0.0026 0.0077 0.0209
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0189 0.1177 0.1847
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0042 0.025
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0567 0.0539
Schistosoma mansoni hepatitis B virus X associated protein hbxa 0.0021 0.0042 0.0012
Echinococcus multilocularis phd finger protein 10 0.0021 0.0042 0.0019
Schistosoma mansoni ap endonuclease 0.0061 0.0313 0.0283
Echinococcus granulosus intermediate filament protein 0.0027 0.008 0.0079
Schistosoma mansoni hypothetical protein 0.0529 0.3491 0.3471
Schistosoma mansoni hypothetical protein 0.0053 0.0257 0.0228
Leishmania major importin beta-1 subunit, putative 0.0048 0.0224 0.0863
Leishmania major GTP-binding protein, putative 0.0022 0.0048 0.0078
Entamoeba histolytica protein kinase, putative 0.0054 0.0264 0.2365
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0145 0.088 0.1369
Entamoeba histolytica hypothetical protein 0.0165 0.102 1
Echinococcus multilocularis zinc finger protein 0.0059 0.0298 0.0431
Schistosoma mansoni coup transcription factor 0.002 0.0036 0.0005
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.003 0.018
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0053 0.0257 0.0365
Brugia malayi TAR-binding protein 0.0065 0.0342 0.0801
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0061 0.0313 1
Echinococcus granulosus Sterile alpha motif type 0.0025 0.0068 0.0061
Echinococcus granulosus Zinc finger DBF type 0.0021 0.0042 0.0019
Echinococcus granulosus PAK box P21 Rho binding 0.0053 0.0257 0.0365
Schistosoma mansoni sex comb on midleg homolog 0.0367 0.239 0.2367
Echinococcus granulosus fetal alzheimer antigen falz 0.0065 0.0341 0.0501
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.2276 1
Schistosoma mansoni lip-related protein (liprin) alpha 0.0025 0.0068 0.0038
Brugia malayi SET domain containing protein 0.0023 0.0054 0.01
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0197 0.04
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.0738 0.1139
Onchocerca volvulus 0.0021 0.0042 0.0017
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.035 0.2276 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0165 0.102 0.1593
Onchocerca volvulus 0.003 0.0101 0.0179
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0189 0.1177 0.1847
Echinococcus granulosus phd finger protein 12 0.0021 0.0042 0.0019
Brugia malayi cask-interacting protein 2 0.0025 0.0068 0.0133
Echinococcus multilocularis cpg binding protein 0.0051 0.0245 0.0346
Loa Loa (eye worm) hypothetical protein 0.0069 0.0366 0.0807
Schistosoma mansoni protein kinase 0.0054 0.0264 0.0235
Echinococcus granulosus chromobox protein 2 0.0197 0.1233 0.1936
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0147 0.151
Echinococcus multilocularis liprin alpha 2 0.0025 0.0068 0.0061
Schistosoma mansoni hypothetical protein 0.0025 0.0068 0.0038
Brugia malayi PHD-finger family protein 0.0021 0.0042 0.0069
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0091
Schistosoma mansoni phd finger protein 0.0021 0.0042 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0042 0.025
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0048 0.0078
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0342 0.0748
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0147 0.052
Onchocerca volvulus 0.0027 0.008 0.0121
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0013
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0633 0.4198 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0036 0.0005
Onchocerca volvulus 0.0262 0.1674 0.4488
Trypanosoma cruzi ISWI complex protein 0.0033 0.0119 0.0397
Echinococcus granulosus histone lysine methyltransferase setb 0.007 0.0373 0.0551
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0054 0.0264 0.0377
Echinococcus multilocularis SAM and MBT domain containing protein 0.0486 0.3197 0.5099
Echinococcus granulosus lamin 0.0027 0.008 0.0079
Echinococcus granulosus remodeling and spacing factor 1 0.0021 0.0042 0.0019
Echinococcus multilocularis geminin 0.0529 0.3491 0.5572
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0257 0.1536
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0342 0.0502
Onchocerca volvulus 0.0403 0.2634 0.7116
Brugia malayi WH1 domain containing protein 0.0053 0.0257 0.0594
Echinococcus multilocularis PHD finger protein 14 0.0021 0.0042 0.0019
Echinococcus multilocularis histone acetyltransferase myst4 0.0021 0.0042 0.0019
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0749 0.1726
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0147 0.0877
Onchocerca volvulus 0.0021 0.0042 0.0017
Brugia malayi exodeoxyribonuclease III family protein 0.0061 0.0313 0.073
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0036 0.0054
Schistosoma mansoni zinc finger protein 0.0059 0.0298 0.0269
Brugia malayi CHD4 protein 0.0033 0.012 0.0259
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.0327 0.2115 0.3356
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0036 0.0005
Schistosoma mansoni lamin 0.0027 0.008 0.005
Schistosoma mansoni hypothetical protein 0.0021 0.0042 0.0012
Trichomonas vaginalis STE family protein kinase 0.0054 0.0264 0.1578
Brugia malayi hypothetical protein 0.0021 0.0042 0.0069
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0189 0.1177 0.2839
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.0738 0.3151
Echinococcus multilocularis lamin dm0 0.0027 0.008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0028
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.008 0.0161
Trichomonas vaginalis ran, putative 0.0022 0.0048 0.0285
Echinococcus multilocularis remodeling and spacing factor 1 0.0021 0.0042 0.0019
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0042 0.0028
Brugia malayi AIDA-1b 0.0025 0.0068 0.0133
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0036 0.0009
Brugia malayi Protein kinase domain 0.0054 0.0264 0.0612
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0025 0.0068 0.0061
Loa Loa (eye worm) hypothetical protein 0.0558 0.3687 0.8775
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0373 0.0343
Loa Loa (eye worm) hypothetical protein 0.0151 0.0924 0.2144
Echinococcus granulosus GPCR family 2 0.0032 0.0114 0.0136
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.007 0.0373 0.0551
Schistosoma mansoni protein kinase 0.0054 0.0264 0.0235
Echinococcus granulosus PHD and RING finger domain containing protein 1 0.0021 0.0042 0.0019
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0025 0.0068 0.0133
Schistosoma mansoni ap endonuclease 0.0061 0.0313 0.0283
Brugia malayi MH2 domain containing protein 0.0125 0.0749 0.1795
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0036 0.0013
Schistosoma mansoni myst-related protein 0.0023 0.0054 0.0024
Brugia malayi P21-Rho-binding domain containing protein 0.0053 0.0257 0.0594
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0025 0.007 0.0063
Plasmodium vivax protein kinase, putative 0.0025 0.0068 0.0973
Loa Loa (eye worm) mbt repeat family protein 0.0378 0.2463 0.5838
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0021 0.0128
Schistosoma mansoni chromobox protein 0.0197 0.1233 0.1206
Brugia malayi jmjC domain containing protein 0.0025 0.007 0.0137
Onchocerca volvulus 0.0025 0.0068 0.0089
Onchocerca volvulus Tankyrase homolog 0.0025 0.0068 0.0089
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0101 0.0212
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0061 0.0313 0.1258
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0145 0.0115
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 24 0.0025 0.0068 0.0169
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0042 0.0019
Echinococcus multilocularis snurportin 1 0.0633 0.4198 0.671
Schistosoma mansoni Protein aveugle 0.0025 0.0068 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0036 0.0054
Trypanosoma cruzi hypothetical protein 0.0025 0.0068 0.0169
Onchocerca volvulus 0.0025 0.0068 0.0089
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0584 0.1328
Onchocerca volvulus 0.0027 0.008 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0036 0.0054
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0147 0.1179
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.003 0.0041
Echinococcus multilocularis polyhomeotic protein 2 0.0025 0.0068 0.0061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0036 0.0009
Trichomonas vaginalis STE family protein kinase 0.0054 0.0264 0.1578
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0042 0.025
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0048 0.0042
Schistosoma mansoni hypothetical protein 0.0165 0.102 0.0993
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0048 0.0028
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0053 0.0257 0.0365
Echinococcus granulosus polyhomeotic protein 2 0.0025 0.0068 0.0061
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0094 0.1939
Loa Loa (eye worm) hypothetical protein 0.0087 0.0488 0.11
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.011
Echinococcus granulosus histone acetyltransferase MYST2 0.0212 0.1335 0.21
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0342 0.0313
Plasmodium vivax JmjC domain containing protein 0.0029 0.0094 0.1939
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0036 0.0013
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0121 0.0809
Schistosoma mansoni PHD zinc finger protein XAP135-related 0.0021 0.0042 0.0012
Entamoeba histolytica protein kinase, putative 0.0054 0.0264 0.2365

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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