Detailed information for compound 1276806

Basic information

Technical information
  • TDR Targets ID: 1276806
  • Name: 1-furan-2-yl-3-[[2-(phenoxy)phenyl]amino]prop -2-en-1-one
  • MW: 305.327 | Formula: C19H15NO3
  • H donors: 1 H acceptors: 1 LogP: 4.87 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccco1)/C=C/Nc1ccccc1Oc1ccccc1
  • InChi: 1S/C19H15NO3/c21-17(19-11-6-14-22-19)12-13-20-16-9-4-5-10-18(16)23-15-7-2-1-3-8-15/h1-14,20H/b13-12+
  • InChiKey: XQSBWXOTJCKMTA-OUKQBFOZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-1-furan-2-yl-3-[[2-(phenoxy)phenyl]amino]prop-2-en-1-one
  • (E)-1-(2-furyl)-3-[[2-(phenoxy)phenyl]amino]prop-2-en-1-one
  • 1-(2-furyl)-3-[[2-(phenoxy)phenyl]amino]prop-2-en-1-one
  • MLS000663748
  • SMR000293038
  • ZINC00608642
  • 1-(2-furyl)-3-[(2-phenoxyphenyl)amino]-2-propen-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.029 0.2768
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0073 0.0268 0.1643
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0047 0.0148 0.0906
Echinococcus granulosus sterol O acyltransferase 1 0.0044 0.013 0.0127
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0073 0.0073
Trichomonas vaginalis porcupine, putative 0.0044 0.013 0.119
Trypanosoma brucei glycerol uptake protein, putative 0.0044 0.013 0.0799
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.026 0.1139 0.3555
Loa Loa (eye worm) MBOAT family protein 0.0044 0.013 0.0119
Plasmodium vivax glutathione reductase, putative 0.0048 0.0149 0.0455
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.163 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0008 0.0005
Echinococcus granulosus alpha 13 mannosyl glycoprotein 0.0109 0.0438 0.0434
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0224 0.0224
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0043 0.0039
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0221 0.0218
Loa Loa (eye worm) hypothetical protein 0.0078 0.029 0.0279
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0028 0.0056 0.0056
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.029 0.1275
Entamoeba histolytica vacuolar protein sorting 26 0.0044 0.013 0.4643
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0022
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0028 0.0056 0.0052
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0028 0.0056 0.0052
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0497 0.2247 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0128 0.0128
Leishmania major glycerol uptake protein, putative 0.0044 0.013 0.0799
Brugia malayi beta-lactamase family protein 0.0078 0.029 0.0286
Loa Loa (eye worm) hypothetical protein 0.0044 0.013 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0116 0.1051
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0061 0.0213 0.2026
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0076 0.0073
Brugia malayi hypothetical protein 0.0028 0.0056 0.0052
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0013 0.003
Plasmodium falciparum methionine--tRNA ligase 0.0061 0.0213 0.0656
Toxoplasma gondii Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 0.0037 0.01 0.0302
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0195 0.0837 0.0834
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0047 0.0148 0.0144
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0047 0.0148 0.0137
Mycobacterium ulcerans beta-lactamase 0.0078 0.029 0.2768
Echinococcus granulosus leukotriene A 4 hydrolase 0.0028 0.0056 0.0052
Echinococcus granulosus aminopeptidase N 0.0028 0.0056 0.0052
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0238 0.1037 0.6359
Trypanosoma cruzi GUP1, putative 0.0044 0.013 0.0799
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.029 0.1275
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0004 0.0022
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0047 0.0148 0.0144
Mycobacterium ulcerans hypothetical protein 0.0078 0.029 0.2768
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0238 0.1037 0.6359
Loa Loa (eye worm) hypothetical protein 0.0028 0.0056 0.0044
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0028 0.0056 0.0044
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0047 0.0148 0.0906
Trypanosoma brucei trypanothione reductase 0.0048 0.0149 0.0914
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.033 0.1467 0.9
Loa Loa (eye worm) hypothetical protein 0.0028 0.0056 0.0044
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0195 0.0837 0.0827
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.029 0.2687
Loa Loa (eye worm) TATA binding protein associated factor 0.0028 0.0056 0.0044
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0733 0.4495
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0149 0.0455
Leishmania major hypothetical protein, conserved 0.0078 0.029 0.1777
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0013 0.0043
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0047 0.0148 0.0906
Brugia malayi Peptidase family M1 containing protein 0.0028 0.0056 0.0052
Brugia malayi Heterochromatin protein 1 0.0072 0.0264 0.026
Brugia malayi hypothetical protein 0.0028 0.0056 0.0052
Brugia malayi Hhat protein 0.0044 0.013 0.0127
Onchocerca volvulus 0.0078 0.029 0.1082
Brugia malayi Thioredoxin reductase 0.0048 0.0149 0.0146
Entamoeba histolytica hypothetical protein 0.0073 0.0265 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0043 0.0039
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0028 0.0056 0.0052
Echinococcus granulosus o acyltransferase membrane bound domain 0.0044 0.013 0.0127
Loa Loa (eye worm) glutathione reductase 0.0048 0.0149 0.0138
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0028 0.0056 0.0341
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0023 0.0036 0.0312
Brugia malayi Peptidase family M1 containing protein 0.0028 0.0056 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0013 0.0088
Echinococcus multilocularis cpg binding protein 0.0033 0.0082 0.0078
Loa Loa (eye worm) hypothetical protein 0.0044 0.013 0.0119
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0028 0.0056 0.0341
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0073 0.0217
Entamoeba histolytica hypothetical protein, conserved 0.0044 0.013 0.4643
Onchocerca volvulus Huntingtin homolog 0.0148 0.0618 0.2599
Brugia malayi methionyl-tRNA synthetase 0.0023 0.0036 0.0032
Onchocerca volvulus 0.0044 0.013 0.0346
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.013 0.119
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0155 0.0151
Toxoplasma gondii thioredoxin reductase 0.0048 0.0149 0.0455
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0036 0.0101
Leishmania major hypothetical protein, conserved 0.0044 0.013 0.0799
Echinococcus multilocularis leucine aminopeptidase protein 0.0238 0.1037 0.1033
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0733 0.4495
Toxoplasma gondii tRNA ligases class I (M) protein 0.0023 0.0036 0.0101
Schistosoma mansoni leucine aminopeptidase 0.0047 0.0148 0.0148
Loa Loa (eye worm) diacylglycerol acyltransferase 0.026 0.1139 0.1129
Mycobacterium ulcerans leucyl aminopeptidase 0.0238 0.1037 1
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.029 0.2687
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.006 0.0533
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.029 0.2768
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.026 0.1139 0.1136
Loa Loa (eye worm) hypothetical protein 0.0109 0.0438 0.0427
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0205 0.0629
Brugia malayi Bromodomain containing protein 0.0079 0.0295 0.0291
Echinococcus multilocularis chromobox protein 1 0.0072 0.0264 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0447 0.4163
Toxoplasma gondii ABC1 family protein 0.0078 0.029 0.0896
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0028 0.0056 0.0341
Trypanosoma cruzi glycerol uptake protein, putative 0.0044 0.013 0.0799
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0028 0.0056 0.0052
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0028 0.0056 0.0052
Entamoeba histolytica hypothetical protein 0.0044 0.013 0.4643
Mycobacterium tuberculosis Conserved protein 0.0078 0.029 0.1275
Schistosoma mansoni hypothetical protein 0.0073 0.0265 0.0265
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.033 0.1467 0.1467
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0064 0.0053
Schistosoma mansoni cpg binding protein 0.003 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0044 0.013 0.013
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0073 0.0069
Loa Loa (eye worm) hypothetical protein 0.0039 0.0111 0.01
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0028 0.0056 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0447 0.4163
Brugia malayi MBOAT family protein 0.0044 0.013 0.0127
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0221 0.0218
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0028 0.0056 0.0341
Brugia malayi glutathione reductase 0.0048 0.0149 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.013 0.119
Loa Loa (eye worm) zinc finger protein 0.0305 0.1353 0.1343
Trypanosoma brucei Aminopeptidase M1, putative 0.0028 0.0056 0.0341
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0024
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.029 0.1275
Brugia malayi beta-lactamase 0.0078 0.029 0.0286
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0264 0.2444
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0044 0.013 0.0127
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0047 0.0148 0.0144
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.029 0.0286
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0028 0.0056 0.0341
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0073 0.0268 0.1643
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0044 0.013 0.0127
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.026 0.1139 0.1139
Leishmania major glycerol uptake protein, putative 0.0044 0.013 0.0799
Onchocerca volvulus 0.0147 0.0614 0.2582
Loa Loa (eye worm) hypothetical protein 0.0028 0.0056 0.0044
Echinococcus granulosus leucyl aminopeptidase 0.0047 0.0148 0.0144
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.029 0.2687
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0044 0.013 0.0127
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0013 0.0088
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0013 0.0088
Plasmodium vivax methionine--tRNA ligase, putative 0.0023 0.0036 0.0101
Toxoplasma gondii hypothetical protein 0.0043 0.0129 0.0394
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0264 0.2444
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0044 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0044 0.013 0.0119
Brugia malayi GNT-I family protein 0.0109 0.0438 0.0434
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0434 0.192
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0078 0.029 0.0279
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0047 0.0148 0.0144
Plasmodium falciparum glutathione reductase 0.0048 0.0149 0.0455
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0078 0.029 0.0279
Echinococcus multilocularis leucyl aminopeptidase 0.0047 0.0148 0.0144
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.025 0.0247
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0238 0.1037 1
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0061 0.0213 0.0202
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.029 0.0286
Loa Loa (eye worm) hypothetical protein 0.0078 0.029 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.006 0.0533
Schistosoma mansoni chromobox protein 0.0072 0.0264 0.0264
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0004 0.0022
Loa Loa (eye worm) hypothetical protein 0.0078 0.029 0.0279
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0028 0.0056 0.0163
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0061 0.0213 0.0933
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0073 0.0268 0.1643
Mycobacterium ulcerans hypothetical protein 0.0073 0.0268 0.2557
Trypanosoma cruzi glycerol uptake protein, putative 0.0044 0.013 0.0799
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0013 0.0088
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.163 1
Brugia malayi PHD-finger family protein 0.0027 0.0054 0.005
Schistosoma mansoni hypothetical protein 0.0032 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0032 0.0076 0.0076
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0028 0.0056 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0013 0.0088
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0028 0.0056 0.0163
Echinococcus granulosus chromobox protein 1 0.0072 0.0264 0.026
Leishmania major diacylglycerol acyltransferase, putative 0.0073 0.0268 0.1643
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0447 0.4163
Brugia malayi Pre-SET motif family protein 0.0031 0.0073 0.0069
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0065 0.0061
Chlamydia trachomatis leucine--tRNA ligase 0.0023 0.0036 0.0312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.0837 0.0837
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.029 0.1777
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0149 0.0146
Schistosoma mansoni zinc finger protein 0.0044 0.013 0.013
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0149 0.0146
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0149 0.0649
Echinococcus granulosus methionine tRNA synthetase 0.0061 0.0213 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0447 0.4163
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0265 0.0262
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0099 0.0096
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0024
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.033 0.1467 0.9
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0028 0.0056 0.0056
Brugia malayi hypothetical protein 0.0073 0.0265 0.0262
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0073 0.0266 0.0255
Trypanosoma cruzi aminopeptidase, putative 0.0028 0.0056 0.0341
Schistosoma mansoni zinc finger protein 0.0022 0.0028 0.0028
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0023 0.0036 0.0312
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0155 0.0155
Leishmania major leucyl-tRNA synthetase, putative 0.0023 0.0036 0.022
Schistosoma mansoni aminopeptidase A (M01 family) 0.0028 0.0056 0.0056
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0022
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.029 0.0286
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0013 0.0081
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.029 0.1275
Brugia malayi Pre-SET motif family protein 0.0215 0.093 0.0927
Schistosoma mansoni cpg binding protein 0.0033 0.0082 0.0082
Echinococcus granulosus chromobox protein 1 0.0072 0.0264 0.026
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0238 0.1037 0.6359
Echinococcus granulosus leucine aminopeptidase protein 0.0238 0.1037 0.1033
Loa Loa (eye worm) hypothetical protein 0.0101 0.04 0.0389
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0434 0.192
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0013 0.0088
Trichomonas vaginalis transmembrane protein nessy, putative 0.0044 0.013 0.119
Mycobacterium leprae conserved hypothetical protein 0.0078 0.029 0.0931
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0447 0.4163
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0166 0.1018
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0028 0.0056 0.0052
Toxoplasma gondii aminopeptidase N, putative 0.07 0.3197 1
Onchocerca volvulus 0.0043 0.0128 0.0336
Brugia malayi MBOAT family protein 0.0044 0.013 0.0127
Leishmania major hypothetical protein, unknown function,protein, unknown function 0.0073 0.0268 0.1643
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0044 0.013 0.0119
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0004 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.0837 0.0837
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0013 0.0081
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0044 0.013 0.0127
Loa Loa (eye worm) hypothetical protein 0.0069 0.025 0.0239
Toxoplasma gondii diacylglycerol acyltransferase 0.0073 0.0268 0.0827
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0244 0.2256
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0447 0.4163
Giardia lamblia Leucyl-tRNA synthetase 0.0023 0.0036 0.1539
Loa Loa (eye worm) hypothetical protein 0.0032 0.0075 0.0063
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0023 0.0036 0.0897
Trypanosoma cruzi glycerol uptake protein, putative 0.0044 0.013 0.0799
Trypanosoma brucei aminopeptidase, putative 0.0028 0.0056 0.0341
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0043 0.0043
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0023 0.0036 0.0032
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0013 0.0093
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.029 0.1777
Onchocerca volvulus 0.0491 0.2218 1
Brugia malayi MBOAT family protein 0.0044 0.013 0.0127
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0028 0.0056 0.0052
Echinococcus granulosus geminin 0.0205 0.0882 0.0879
Toxoplasma gondii hypothetical protein 0.0059 0.0201 0.0619
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0044 0.013 0.0127
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0047 0.0148 0.0906
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0238 0.1037 0.3235
Echinococcus multilocularis sterol O acyltransferase 1 0.0044 0.013 0.0127
Brugia malayi diacylglycerol acyltransferase 0.026 0.1139 0.1136
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.093 0.092
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0044 0.013 0.4643
Brugia malayi Zinc finger, C2H2 type family protein 0.0305 0.1353 0.135
Schistosoma mansoni bromodomain containing protein 0.0067 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.2156 1 1
Schistosoma mansoni methionine-tRNA synthetase 0.0023 0.0036 0.0036
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0013 0.009
Plasmodium falciparum methionine--tRNA ligase, putative 0.0023 0.0036 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0447 0.4163
Trypanosoma cruzi Aminopeptidase M1, putative 0.0028 0.0056 0.0341
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0022
Trypanosoma cruzi aminopeptidase, putative 0.0028 0.0056 0.0341
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0491 0.3374
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0116 0.1051
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0061 0.0213 0.2026
Leishmania major glycerol uptake protein, putative 0.0044 0.013 0.0799
Loa Loa (eye worm) hypothetical protein 0.004 0.0116 0.0104
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0044 0.013 0.0127
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0004 0.0022
Loa Loa (eye worm) aminopeptidase N 0.0028 0.0056 0.0044
Loa Loa (eye worm) hhat protein 0.0044 0.013 0.0119
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0076 0.0073
Loa Loa (eye worm) hypothetical protein 0.0216 0.0935 0.0925
Brugia malayi Bromodomain containing protein 0.0039 0.0111 0.0107
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0013 0.0758
Trichomonas vaginalis chromobox protein, putative 0.0044 0.013 0.1186
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0434 0.2686
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0028 0.0056 0.0488
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.0837 0.0834
Brugia malayi diacylglycerol acyltransferase family protein 0.033 0.1467 0.1464
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0434 0.192
Echinococcus granulosus o acyltransferase membrane bound domain 0.0044 0.013 0.0127
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0073 0.0268 0.0268
Loa Loa (eye worm) diacylglycerol acyltransferase 0.033 0.1467 0.1457
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0028 0.0056 0.0056
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.026 0.1139 0.3555
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0013 0.0459
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0028 0.0056 0.0052
Plasmodium falciparum M17 leucyl aminopeptidase 0.0238 0.1037 0.3235
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.04 0.0389
Toxoplasma gondii hypothetical protein 0.0044 0.013 0.0397
Onchocerca volvulus 0.0038 0.0104 0.0222
Echinococcus multilocularis aminopeptidase N 0.0028 0.0056 0.0052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.029 0.029
Toxoplasma gondii aminopeptidase N protein 0.07 0.3197 1
Giardia lamblia Methionyl-tRNA synthetase 0.0061 0.0213 1
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.2156 1 1
Brugia malayi Peptidase family M1 containing protein 0.0028 0.0056 0.0052
Brugia malayi protein ZK524.3 0.0023 0.0036 0.0032
Echinococcus granulosus zinc finger protein 0.0022 0.0028 0.0025
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0264 0.0253
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0044 0.013 0.013
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.029 0.1275
Toxoplasma gondii methionyl-tRNA synthetase 0.0061 0.0213 0.0656
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0028 0.0056 0.0341
Echinococcus multilocularis leucyl tRNA synthetase 0.0023 0.0036 0.0032
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0491 0.2172
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0061 0.0213 0.1306
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0076 0.0073
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.029 0.0279
Trypanosoma brucei aminopeptidase, putative 0.0047 0.0148 0.0906
Echinococcus granulosus zinc finger transcription factor gli2 0.0305 0.1353 0.135
Toxoplasma gondii leucyl aminopeptidase LAP 0.0238 0.1037 0.3235
Loa Loa (eye worm) hypothetical protein 0.0032 0.0076 0.0065
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0023 0.0036 0.0032
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0028 0.0056 0.0056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0195 0.0837 0.0834
Toxoplasma gondii dgat2l1-prov protein 0.033 0.1467 0.4583
Treponema pallidum alginate O-acetylation protein (algI) 0.0044 0.013 1
Loa Loa (eye worm) MBOAT family protein 0.0044 0.013 0.0119
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.029 0.1777
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0022
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0028 0.0056 0.0341
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0013 0.0093
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0013 0.0081
Toxoplasma gondii exonuclease III APE 0.0019 0.0013 0.003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0218 0.134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0022
Echinococcus granulosus dnaJ subfamily B 0.0421 0.1892 0.1889
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.013 0.0344
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.04 0.0397
Mycobacterium leprae Probable lipase LipE 0.0078 0.029 0.0931
Brugia malayi MBOAT family protein 0.0044 0.013 0.0127
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0004 0.0022
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0434 0.192
Echinococcus multilocularis leucyl aminopeptidase 0.0047 0.0148 0.0144
Brugia malayi hypothetical protein 0.0148 0.0618 0.0614
Toxoplasma gondii mono- or diacylglycerol acyltransferase 0.0073 0.0268 0.0827
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0265 0.0262
Onchocerca volvulus 0.0078 0.029 0.1082
Trypanosoma brucei glycerol uptake protein, putative 0.0044 0.013 0.0799
Entamoeba histolytica hypothetical protein 0.0073 0.0265 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0155 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0078 0.029 0.0279
Echinococcus multilocularis chromobox protein 1 0.0072 0.0264 0.026
Brugia malayi Glycosylation related protein 12, isoform 0.0037 0.01 0.0096
Echinococcus granulosus o acyltransferase membrane bound domain 0.0044 0.013 0.0127
Trichomonas vaginalis set domain proteins, putative 0.0244 0.1068 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0618 0.0607
Brugia malayi hypothetical protein 0.0147 0.0614 0.0611
Mycobacterium tuberculosis Conserved protein 0.0078 0.029 0.1275
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0073 0.0268 0.1643
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0028 0.0056 0.0488
Plasmodium vivax hypothetical protein, conserved 0.0078 0.029 0.0896
Echinococcus multilocularis leucyl aminopeptidase 0.0047 0.0148 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.013 0.119
Loa Loa (eye worm) hypothetical protein 0.0042 0.0122 0.0111
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0824 0.3657
Leishmania major glycerol uptake protein, putative 0.0044 0.013 0.0799
Brugia malayi Pax transcription factor protein 2 0.0491 0.2218 0.2216
Echinococcus granulosus leucyl aminopeptidase 0.0047 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.0148 0.0618 0.0607
Leishmania major diacylglycerol acyltransferase, putative 0.033 0.1467 0.9
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0195 0.0837 0.0837
Loa Loa (eye worm) hypothetical protein 0.0044 0.013 0.0119
Trypanosoma cruzi GUP1, putative 0.0044 0.013 0.0799
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0013 0.0088
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.029 0.1275
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0004 0.0022
Echinococcus multilocularis GPCR, family 2 0.0032 0.0076 0.0073
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0013 0.001
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0073 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0037 0.01 0.0089
Trypanosoma brucei Aminopeptidase M1, putative 0.0028 0.0056 0.0341
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0028 0.0056 0.0052
Schistosoma mansoni hypothetical protein 0.0073 0.0268 0.0268
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0022
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0238 0.1037 0.4606
Mycobacterium tuberculosis Conserved protein 0.0078 0.029 0.1275
Schistosoma mansoni hypothetical protein 0.0205 0.0882 0.0882
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0022
Brugia malayi beta-lactamase family protein 0.0078 0.029 0.0286
Loa Loa (eye worm) pax transcription factor protein 2 0.0491 0.2218 0.221
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0013 0.001
Schistosoma mansoni hypothetical protein 0.0032 0.0076 0.0076
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0028 0.0056 0.0052
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0166 0.1018
Brugia malayi TATA binding protein associated factor 0.0028 0.0056 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0036 0.0024
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0008 0.0008
Onchocerca volvulus Huntingtin homolog 0.0148 0.0618 0.2599
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0028 0.0056 0.0488
Toxoplasma gondii aminopeptidase n, putative 0.07 0.3197 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0047 0.0148 0.0906
Plasmodium falciparum M1-family alanyl aminopeptidase 0.07 0.3197 1
Schistosoma mansoni methionine-tRNA synthetase 0.0061 0.0213 0.0213
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0047 0.0148 0.0148
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.033 0.1467 0.9
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0044 0.013 0.013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0013 0.0088
Loa Loa (eye worm) peptidase family M1 containing protein 0.0028 0.0056 0.0044
Loa Loa (eye worm) beta-lactamase 0.0078 0.029 0.0279
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0061 0.0213 0.1967
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0047 0.0148 0.0906
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0149 0.0138
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0013 0.0002
Schistosoma mansoni chromobox protein 0.0072 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0109 0.0438 0.0427
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0044 0.013 0.4643
Leishmania major trypanothione reductase 0.0048 0.0149 0.0914
Echinococcus multilocularis zinc finger protein 0.0022 0.0028 0.0025
Onchocerca volvulus 0.033 0.1467 0.6527
Echinococcus granulosus GPCR family 2 0.0032 0.0076 0.0073
Mycobacterium ulcerans lipase LipD 0.0078 0.029 0.2768
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0076 0.0065
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0166 0.1018
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0044 0.013 0.013
Onchocerca volvulus 0.003 0.0064 0.0041
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.2156 1 1
Treponema pallidum methionyl-tRNA synthetase 0.0023 0.0036 0.2544
Mycobacterium ulcerans hypothetical protein 0.0192 0.0824 0.794
Entamoeba histolytica hypothetical protein 0.0073 0.0265 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0028 0.0056 0.0341
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0099 0.0096
Chlamydia trachomatis cytosol aminopeptidase 0.0238 0.1037 1
Trichomonas vaginalis esterase, putative 0.0078 0.029 0.2687
Loa Loa (eye worm) hypothetical protein 0.0049 0.0155 0.0144
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.026 0.1139 0.3555
Echinococcus multilocularis methionine tRNA synthetase 0.0061 0.0213 0.0209
Loa Loa (eye worm) hhat protein 0.0044 0.013 0.0119
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0044 0.013 0.0127
Entamoeba histolytica hypothetical protein 0.0073 0.0265 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0013 0.003
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0434 0.192
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.026 0.1139 0.1136
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.029 0.2687
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0076 0.0073
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0044 0.013 0.013
Entamoeba histolytica aminopeptidase, putative 0.0028 0.0056 0.1679
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0447 0.4163
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.07 0.3197 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.163 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.0614 0.0603
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0733 0.4495
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0265 0.0265
Plasmodium falciparum diacylglycerol O-acyltransferase 0.026 0.1139 0.3555
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.0837 0.0834
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0044 0.013 0.0127
Onchocerca volvulus 0.0078 0.029 0.1082
Schistosoma mansoni hypothetical protein 0.0205 0.0882 0.0882
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0149 0.0914
Leishmania major methionyl-tRNA synthetase, putative 0.0061 0.0213 0.1306
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.029 0.1275
Plasmodium falciparum thioredoxin reductase 0.0048 0.0149 0.0455
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0038 0.0104 0.0092
Chlamydia trachomatis methionine--tRNA ligase 0.0023 0.0036 0.0312
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.04 0.0397
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0022
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0073 0.0268 0.1643
Schistosoma mansoni alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase 0.0109 0.0438 0.0438
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.029 0.029
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0044 0.013 0.0127
Schistosoma mansoni cpg binding protein 0.0033 0.0082 0.0082
Schistosoma mansoni sterol O-acyltransferase 1 0.0044 0.013 0.013
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0044 0.013 0.0127
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0047 0.0148 0.0137
Schistosoma mansoni leucyl-tRNA synthetase 0.0023 0.0036 0.0036
Mycobacterium tuberculosis Probable reductase 0.0109 0.0434 0.192
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.163 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0047 0.0148 0.0906
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0238 0.1037 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0028 0.0056 0.0052
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0013 0.0081
Schistosoma mansoni hypothetical protein 0.0421 0.1892 0.1892
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0028 0.0056 0.0052
Brugia malayi methionyl-tRNA synthetase 0.0061 0.0213 0.0209
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0116 0.0277
Leishmania major diacylglycerol acyltransferase, putative 0.0073 0.0268 0.1643
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.1892 0.1889
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0166 0.1018
Mycobacterium ulcerans aminopeptidase N PepN 0.0028 0.0056 0.0503
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0022
Trichomonas vaginalis chromobox protein, putative 0.0044 0.013 0.1186
Loa Loa (eye worm) MBOAT family protein 0.0044 0.013 0.0119
Brugia malayi cytosol aminopeptidase 0.0047 0.0148 0.0144
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0238 0.1037 0.6359
Echinococcus granulosus cpg binding protein 0.0033 0.0082 0.0078
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.2156 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0195 0.0837 0.0834
Treponema pallidum leucyl-tRNA synthetase 0.0023 0.0036 0.2544
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0028 0.0056 0.0341
Onchocerca volvulus 0.0032 0.0075 0.0089
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0076 0.0073
Echinococcus multilocularis geminin 0.0205 0.0882 0.0879
Brugia malayi CXXC zinc finger family protein 0.003 0.0064 0.0061
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0008 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.029 0.2687
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0491 0.2172
Echinococcus multilocularis alpha 1,3 mannosyl glycoprotein 0.0109 0.0438 0.0434
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0491 0.2172
Echinococcus multilocularis zinc finger transcription factor gli2 0.0305 0.1353 0.135
Mycobacterium ulcerans aminopeptidase N PepN 0.0028 0.0056 0.0503
Brugia malayi MBOAT family protein 0.0044 0.013 0.0127
Onchocerca volvulus 0.0244 0.1068 0.4682
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0061 0.0213 0.1306
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0026 0.0014
Schistosoma mansoni hypothetical protein 0.0021 0.0026 0.0026
Plasmodium vivax SET domain protein, putative 0.0031 0.0073 0.0217
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0076 0.0073
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0044 0.013 0.0127
Loa Loa (eye worm) hypothetical protein 0.0046 0.0139 0.0128
Schistosoma mansoni hypothetical protein 0.0032 0.0076 0.0076
Brugia malayi chromobox protein homolog 3 0.004 0.0116 0.0112
Leishmania major glycerol uptake protein, putative 0.0044 0.013 0.0799
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0004 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0013 0.009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0004 0.0022
Plasmodium vivax methionine--tRNA ligase, putative 0.0061 0.0213 0.0656
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0004 0.0022
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0044 0.013 0.4643
Schistosoma mansoni hypothetical protein 0.0069 0.025 0.025

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 1.1689 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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