Detailed information for compound 1278203

Basic information

Technical information
  • TDR Targets ID: 1278203
  • Name: 2-methylsulfanyl-7-[4-(phenoxy)phenyl]-[1,2,4 ]triazolo[1,5-a]pyrimidine
  • MW: 334.395 | Formula: C18H14N4OS
  • H donors: 0 H acceptors: 3 LogP: 4.13 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1nn2c(n1)nccc2c1ccc(cc1)Oc1ccccc1
  • InChi: 1S/C18H14N4OS/c1-24-18-20-17-19-12-11-16(22(17)21-18)13-7-9-15(10-8-13)23-14-5-3-2-4-6-14/h2-12H,1H3
  • InChiKey: ZRSNXHIQTYMUPX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(methylthio)-7-[4-(phenoxy)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidine
  • ZINC01395676
  • 2-(methylsulfanyl)-7-(4-phenoxyphenyl)[1,2,4]triazolo[1,5-a]pyrimidine
  • MLS000539474
  • SMR000125132
  • 12C-087

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0439 0.094 0.2012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0427 0.0913 0.1955
Loa Loa (eye worm) acetyltransferase 0.029 0.0607 0.1777
Trypanosoma brucei Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0041 0.005 0.0239
Plasmodium falciparum thioredoxin reductase 0.0134 0.0258 0.142
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0012 0.0023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Mycobacterium ulcerans N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB 0.0051 0.0072 0.0064
Trichomonas vaginalis ran, putative 0.0022 0.0008 0.0046
Brugia malayi Latrophilin receptor protein 2 0.0439 0.094 0.2751
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0427 0.0913 0.1955
Echinococcus granulosus Smad4 0.0025 0.0014 0.003
Leishmania major DNA polymerase eta, putative 0.0085 0.0149 0.0805
Trypanosoma cruzi UDP-galactose 4-epimerase 0.0057 0.0086 0.0444
Echinococcus multilocularis beta LACTamase domain containing family member 0.0335 0.0708 0.1515
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0018 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0076 0.013 0.0278
Leishmania major importin beta-1 subunit, putative 0.0024 0.0013 0.0031
Echinococcus multilocularis short transient receptor potential channel 6 0.0135 0.0261 0.0558
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0427 0.0913 0.1955
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0063 0.0315
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0005 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0558 0.1204 0.6802
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0063 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0152 0.0821
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0071 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0152 0.0821
Loa Loa (eye worm) glutaminase 0.0275 0.0573 0.1677
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0041 0.005 0.0106
Echinococcus multilocularis histone deacetylase 7 0.0596 0.1289 0.2758
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0008 0.0023
Trypanosoma brucei trypanothione reductase 0.0134 0.0258 0.142
Trichomonas vaginalis bromodomain-containing protein, putative 0.0087 0.0154 0.0868
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0012 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0005 0.0014
Echinococcus granulosus histone deacetylase 8 0.0317 0.0667 0.1427
Plasmodium falciparum histone deacetylase 2 0.0596 0.1289 0.7267
Brugia malayi histone deacetylase 1 (HD1) 0.0811 0.177 0.5181
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.029 0.0607 0.13
Brugia malayi PHD-finger family protein 0.0035 0.0037 0.0109
Mycobacterium tuberculosis Probable reductase 0.0305 0.0641 0.064
Brugia malayi Transient-receptor-potential like protein 0.0076 0.0129 0.0377
Schistosoma mansoni inositol transporter 0.0078 0.0134 0.0286
Loa Loa (eye worm) hypothetical protein 0.0335 0.0708 0.2071
Entamoeba histolytica hypothetical protein 0.0112 0.021 0.1187
Trichomonas vaginalis mercuric reductase, putative 0.0046 0.0063 0.0353
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0305 0.0641 0.064
Echinococcus granulosus high affinity choline transporter 1 0.071 0.1543 0.3304
Echinococcus granulosus importin subunit beta 1 0.003 0.0026 0.0055
Loa Loa (eye worm) hypothetical protein 0.071 0.1543 0.4517
Loa Loa (eye worm) hypothetical protein 0.0811 0.177 0.5181
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0041 0.005 0.0106
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0005 0.0043
Giardia lamblia Histone acetyltransferase GCN5 0.0078 0.0132 0.0705
Trichomonas vaginalis UDP-glucose 4-epimerase, putative 0.0057 0.0086 0.0487
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.013 0.0693
Giardia lamblia Hypothetical protein 0.0041 0.005 0.0236
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.007 0.0353
Trypanosoma brucei histone deacetylase, putative 0.0596 0.1289 0.7267
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0012 0.0066
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.0189 0.0404
Echinococcus granulosus tumor protein p63 0.0702 0.1527 0.3269
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0799 0.1742 0.3728
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0063 0.4484
Mycobacterium tuberculosis Conserved protein 0.0335 0.0708 0.0708
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0005 0.0043
Plasmodium vivax histone deacetylase, putative 0.0596 0.1289 0.7267
Brugia malayi histone deacetylase 3 (HD3) 0.0811 0.177 0.5181
Brugia malayi acetyltransferase, GNAT family protein 0.029 0.0607 0.1777
Brugia malayi Smad1 0.0025 0.0014 0.0041
Schistosoma mansoni transient receptor potential channel 0.0204 0.0415 0.0889
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0005 0.001
Toxoplasma gondii N-acetylglucosaminylphosphatidylinositol deacetylase 0.0051 0.0072 0.0365
Echinococcus multilocularis BRCA1 associated protein 0.0041 0.005 0.0106
Mycobacterium tuberculosis Conserved hypothetical protein 0.0051 0.0072 0.0065
Mycobacterium tuberculosis Probable oxidoreductase 0.0339 0.0717 0.0717
Trichomonas vaginalis histone deacetylase, putative 0.0811 0.177 1
Trichomonas vaginalis brca1-associated protein, putative 0.0041 0.005 0.0281
Echinococcus multilocularis Smad4 0.0025 0.0014 0.003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0005 0.0043
Trypanosoma brucei UDP-galactose 4-epimerase 0.0055 0.0082 0.042
Echinococcus multilocularis geminin 0.2111 0.4672 1
Onchocerca volvulus 0.0021 0.0005 0.0043
Echinococcus granulosus geminin 0.2111 0.4672 1
Entamoeba histolytica histone deacetylase, putative 0.0811 0.177 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.013 0.0278
Brugia malayi nuclear hormone receptor 0.0021 0.0005 0.0014
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0018 0.0805
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0014 0.003
Echinococcus granulosus DNA methyltransferase 2, putative 0.0022 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0439 0.094 0.2751
Trypanosoma cruzi histone deacetylase, putative 0.0596 0.1289 0.7267
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0005 0.001
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0071 0.0152
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0046 0.0063 0.0312
Mycobacterium leprae N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha-D-Glucopyranoside Deacetylase MshB (GlcNAc-Ins deacetylase) 0.0051 0.0072 0.0054
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0001
Echinococcus granulosus neuropeptide s receptor 0.0558 0.1206 0.2581
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0145 0.0821
Loa Loa (eye worm) glutathione reductase 0.0134 0.0258 0.0755
Leishmania major trypanothione reductase 0.0134 0.0258 0.142
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Trypanosoma cruzi histone deacetylase, putative 0.0596 0.1289 0.7267
Echinococcus multilocularis GPCR, family 2 0.0439 0.094 0.2012
Loa Loa (eye worm) UDP galactose 4'-epimerase 0.0057 0.0086 0.0252
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0811 0.177 1
Echinococcus granulosus histone deacetylase 3 0.0811 0.177 0.3789
Brugia malayi BRCA1-associated protein 2 containing protein 0.0041 0.005 0.0145
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0106 0.0309
Loa Loa (eye worm) hypothetical protein 0.0086 0.015 0.044
Schistosoma mansoni hypothetical protein 0.2111 0.4672 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0005 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0013 0.0074
Entamoeba histolytica Ran family GTPase 0.0022 0.0008 0.0046
Brugia malayi hypothetical protein 0.005 0.007 0.0205
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0005 0.001
Brugia malayi TAR-binding protein 0.0076 0.013 0.038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0335 0.0708 0.1515
Echinococcus granulosus GPCR family 2 0.0439 0.094 0.2012
Trichomonas vaginalis histone deacetylase, putative 0.0811 0.177 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0014 0.003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0075 0.0126 0.0369
Trypanosoma brucei DNA polymerase eta, putative 0.0085 0.0149 0.0805
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.013 0.0122
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0063 0.0315
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0046 0.0063 0.0055
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.005 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0005 0.0014
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0041 0.005 0.0106
Leishmania major DNA polymerase eta, putative 0.0046 0.0062 0.0307
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0008 0.0045
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0015 0.0041
Trypanosoma cruzi histone deacetylase, putative 0.0317 0.0667 0.3738
Loa Loa (eye worm) hypothetical protein 0.0085 0.0149 0.0437
Leishmania major N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase 0.0051 0.0072 0.0365
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0078 0.0134 0.0716
Loa Loa (eye worm) hypothetical protein 0.0069 0.0114 0.0332
Echinococcus multilocularis histone deacetylase 8 0.0317 0.0667 0.1427
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.005 0.0236
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0026 0.0103
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0339 0.0717 0.0717
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0046 0.0063 0.0312
Loa Loa (eye worm) hypothetical protein 0.0054 0.0079 0.0232
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0152 0.0821
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0026 0.0103
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0063 0.4484
Schistosoma mansoni smad 0.0025 0.0014 0.003
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0005 0.001
Brugia malayi Probable ClpP-like protease 0.0076 0.013 0.0379
Loa Loa (eye worm) glutaminase 2 0.0275 0.0573 0.1677
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0005 0.001
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0339 0.0717 0.07
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0008 0.0017
Trypanosoma brucei unspecified product 0.0079 0.0136 0.0728
Loa Loa (eye worm) histone deacetylase 11 0.0317 0.0667 0.1951
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0134 0.0258 0.0253
Brugia malayi steroid hormone receptor 0.0021 0.0005 0.0014
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0051 0.0072 0.0363
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0063 0.0312
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.013 0.0693
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0152 0.0818
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0046 0.0063 0.0312
Schistosoma mansoni UDP-glucose 4-epimerase 0.0057 0.0086 0.0184
Schistosoma mansoni hypothetical protein 0.0439 0.094 0.2012
Trichomonas vaginalis glucosylceramidase, putative 0.0529 0.114 0.6442
Echinococcus multilocularis transient receptor potential gamma protein 0.0204 0.0415 0.0889
Echinococcus multilocularis histone deacetylase 1 0.0811 0.177 0.3789
Trichomonas vaginalis histone deacetylase, putative 0.0811 0.177 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0135 0.0261 0.0558
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0064 0.0103 0.0096
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0305 0.0641 0.0624
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0044 0.0094
Brugia malayi Histone deacetylase family protein 0.0596 0.1289 0.3771
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0057 0.0086 0.0487
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.005 0.0239
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0087 0.0152 0.086
Trichomonas vaginalis DNA polymerase eta, putative 0.0087 0.0152 0.086
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0087 0.0154 0.0868
Echinococcus granulosus dna polymerase kappa 0.0087 0.0152 0.0326
Trypanosoma brucei histone deacetylase 1 0.0811 0.177 1
Brugia malayi polk-prov protein 0.0047 0.0065 0.0189
Echinococcus granulosus histone acetyltransferase KAT2B 0.0087 0.0154 0.0329
Entamoeba histolytica hypothetical protein 0.0024 0.0013 0.0074
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.0672 0.1966
Schistosoma mansoni transient receptor potential channel 4 0.0204 0.0415 0.0889
Schistosoma mansoni transient receptor potential channel 0.0135 0.0261 0.0558
Loa Loa (eye worm) hypothetical protein 0.0086 0.015 0.044
Echinococcus multilocularis histone deacetylase 0.0596 0.1289 0.2758
Leishmania major udp-glc 4-epimerase, putative 0.0055 0.0082 0.042
Trichomonas vaginalis glucosylceramidase, putative 0.0529 0.114 0.6442
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0335 0.0708 0.2071
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0075
Schistosoma mansoni importin beta-1 0.003 0.0026 0.0055
Loa Loa (eye worm) TAR-binding protein 0.0076 0.013 0.038
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0086 0.0079
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.013 0.0693
Schistosoma mansoni tar DNA-binding protein 0.0076 0.013 0.0278
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0152 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0427 0.0913 0.1955
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0119 0.0256
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.029 0.0607 0.13
Echinococcus granulosus zinc finger protein 0.0029 0.0025 0.0053
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0003
Trypanosoma brucei unspecified product 0.0039 0.0047 0.0222
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0005 0.001
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0046 0.0063 0.0134
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0005 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0807 0.176 0.994
Schistosoma mansoni DNA polymerase eta 0.0085 0.0149 0.032
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0145 0.0821
Echinococcus granulosus TRP transient receptor potential channel 0.0076 0.0129 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0005 0.0014
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0012 0.0025
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0152 0.0818
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0008 0.0017
Trichomonas vaginalis histone deacetylase, putative 0.0811 0.177 1
Schistosoma mansoni ap endonuclease 0.0022 0.0008 0.0017
Onchocerca volvulus 0.0066 0.0106 0.0926
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0005 0.001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0005 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0807 0.176 0.994
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.005 0.0281
Schistosoma mansoni cpg binding protein 0.0066 0.0106 0.0226
Trichomonas vaginalis glucosylceramidase, putative 0.0558 0.1204 0.6802
Echinococcus granulosus dna polymerase eta 0.0085 0.0149 0.032
Loa Loa (eye worm) hypothetical protein 0.0076 0.013 0.0379
Brugia malayi hypothetical protein 0.0112 0.021 0.0615
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0046 0.0063 0.0134
Loa Loa (eye worm) hypothetical protein 0.0103 0.0189 0.0552
Brugia malayi hypothetical protein 0.0032 0.0031 0.009
Brugia malayi Bromodomain containing protein 0.0088 0.0155 0.0455
Echinococcus granulosus BRCA1 associated protein 0.0041 0.005 0.0106
Echinococcus granulosus histone deacetylase 1 0.0811 0.177 0.3789
Brugia malayi ecdysteroid receptor 0.0021 0.0005 0.0014
Schistosoma mansoni ran 0.0022 0.0008 0.0017
Schistosoma mansoni hypothetical protein 0.0112 0.021 0.045
Mycobacterium tuberculosis Probable esterase LipL 0.0335 0.0708 0.0708
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.0086 0.0185
Trypanosoma cruzi DNA polymerase eta, putative 0.0085 0.0149 0.0803
Leishmania major histone deacetylase, putative 0.0811 0.177 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0005 0.0014
Plasmodium falciparum N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0051 0.0072 0.0365
Loa Loa (eye worm) hypothetical protein 0.005 0.007 0.0205
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1549 0.3417 1
Echinococcus multilocularis zinc finger protein 0.0029 0.0025 0.0053
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0152 0.0818
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.013 1
Echinococcus multilocularis tumor protein p63 0.0702 0.1527 0.3269
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.06 0.1298 0.2778
Onchocerca volvulus 0.0103 0.0189 0.1653
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.0204 0.0415 0.1216
Trichomonas vaginalis glucosylceramidase, putative 0.0529 0.114 0.6442
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.007 0.0355
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0041 0.005 0.0145
Schistosoma mansoni histone deacetylase 0.0811 0.177 0.3789
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0005 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0054 0.0157
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0087 0.0154 0.0828
Plasmodium vivax importin-beta 2, putative 0.003 0.0026 0.0103
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0041 0.005 0.0239
Trichomonas vaginalis glucosylceramidase, putative 0.0529 0.114 0.6442
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0005 0.001
Echinococcus granulosus transient receptor potential ion channel A 0.0198 0.04 0.0857
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0427 0.0913 0.1955
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0008 0.0003
Plasmodium vivax hypothetical protein, conserved 0.0041 0.005 0.0239
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0078 0.0134 0.0286
Entamoeba histolytica hypothetical protein 0.0112 0.021 0.1187
Trypanosoma cruzi histone deacetylase, putative 0.0596 0.1289 0.7267
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0013 0.0074
Schistosoma mansoni smad1 5 8 and 0.0025 0.0014 0.003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0005 0.001
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.013 0.0112
Echinococcus multilocularis histone deacetylase 6 0.0596 0.1289 0.2758
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0041 0.005 0.0106
Leishmania major hypothetical protein, conserved 0.0041 0.005 0.0239
Loa Loa (eye worm) hypothetical protein 0.0076 0.0129 0.0377
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.013 1
Echinococcus granulosus cpg binding protein 0.0069 0.0114 0.0244
Loa Loa (eye worm) beta-lactamase 0.0335 0.0708 0.2071
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0022 0.0008 0.0016
Loa Loa (eye worm) histone deacetylase 0.0596 0.1289 0.3771
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0008 0.0017
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.005 0.0145
Mycobacterium tuberculosis Probable dehydrogenase 0.0305 0.0641 0.064
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.005 0.0239
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0046 0.0063 0.0055
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0012 0.0023
Entamoeba histolytica UDP-glucose 4-epimerase, putative 0.0057 0.0086 0.0487
Echinococcus multilocularis dna polymerase eta 0.0085 0.0149 0.032
Schistosoma mansoni hypothetical protein 0.0439 0.094 0.2012
Schistosoma mansoni histone deacetylase hda2 0.0636 0.1379 0.2952
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0078 0.0134 0.0286
Schistosoma mansoni hypothetical protein 0.0949 0.2078 0.4449
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0034 0.0035 0.0103
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0014 0.003
Echinococcus granulosus histone deacetylase 6 0.0596 0.1289 0.2758
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0041 0.005 0.0281
Brugia malayi histone deacetylase 11 0.0317 0.0667 0.1951
Toxoplasma gondii histone deacetylase HDAC3 0.0811 0.177 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.0086 0.0185
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0008 0.0002
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0811 0.177 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0063 0.031
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0014 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0005 0.0014
Mycobacterium tuberculosis Conserved protein 0.0335 0.0708 0.0708
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0008 0.0045
Loa Loa (eye worm) phosphatidylinositol glycan anchor biosynthesis protein 0.0051 0.0072 0.0211
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0005 0.001
Mycobacterium tuberculosis Probable hydrolase 0.0335 0.0708 0.0708
Schistosoma mansoni coup transcription factor 0.0021 0.0005 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0112 0.021 0.045
Trichomonas vaginalis glucosylceramidase, putative 0.0529 0.114 0.6442
Toxoplasma gondii histone deacetylase HDAC1 0.0596 0.1289 0.7267
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0335 0.0708 0.0708
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.005 0.0239
Brugia malayi Histone deacetylase family protein 0.0596 0.1289 0.3771
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.0041 0.005 0.0281
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.005 0.0281
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0008 0.0017
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0086 0.0252
Trypanosoma cruzi trypanothione reductase, putative 0.0134 0.0258 0.1418
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0012 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.0335 0.0708 0.3998
Schistosoma mansoni hypothetical protein 0.2111 0.4672 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0005 0.001
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0041 0.005 0.0239
Brugia malayi MH1 domain containing protein 0.0025 0.0014 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0152 0.0821
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0012 0.002
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0041 0.005 0.0106
Leishmania major hypothetical protein, conserved 0.0335 0.0708 0.3972
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0005 0.0014
Echinococcus granulosus thioredoxin glutathione reductase 0.0134 0.0259 0.0554
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0041 0.005 0.0145
Trypanosoma cruzi N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative 0.0051 0.0072 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0152 0.0821
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0001 0.0001
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0041 0.005 0.0239
Schistosoma mansoni brca1-associated protein (brap2) 0.0041 0.005 0.0106
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0152 0.0821
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0046 0.0063 0.0312
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.013 0.0278
Brugia malayi MH2 domain containing protein 0.0025 0.0014 0.0041
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0063 0.031
Trypanosoma cruzi histone deacetylase, putative 0.0317 0.0667 0.3738
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0811 0.177 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0427 0.0913 0.1955
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0005 0.0014
Loa Loa (eye worm) thioredoxin reductase 0.0134 0.0258 0.0755
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.013 1
Toxoplasma gondii UDP-glucose 4-epimerase 0.0057 0.0086 0.0446
Giardia lamblia UDP-glucose 4-epimerase 0.0055 0.0082 0.0418
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.005 0.0281
Plasmodium falciparum glutathione reductase 0.0134 0.0258 0.142
Plasmodium vivax histone deacetylase, putative 0.0317 0.0667 0.3739
Trypanosoma cruzi hypothetical protein, conserved 0.0335 0.0708 0.3971
Loa Loa (eye worm) hypothetical protein 0.0335 0.0708 0.2071
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.013 0.038
Loa Loa (eye worm) hypothetical protein 0.0041 0.005 0.0145
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0439 0.094 0.2012
Schistosoma mansoni tar DNA-binding protein 0.0076 0.013 0.0278
Toxoplasma gondii histone deacetylase HDAC2 0.0811 0.177 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0807 0.176 0.515
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0009 0.0019
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.005 0.0281
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Echinococcus granulosus histone deacetylase 6 0.0636 0.1379 0.2952
Schistosoma mansoni eyes absent homolog 0.0086 0.015 0.0322
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0008 0.0045
Trypanosoma brucei histone deacetylase 4 0.0596 0.1289 0.7267
Plasmodium vivax histone deacetylase 1, putative 0.0811 0.177 1
Schistosoma mansoni sodium/solute symporter 0.0078 0.0134 0.0286
Brugia malayi MH2 domain containing protein 0.0361 0.0764 0.2236
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0041 0.005 0.0106
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0005 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0152 0.0821
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0093 0.0167 0.0906
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0041 0.005 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0065 0.0323
Schistosoma mansoni bromodomain containing protein 0.0076 0.0128 0.0274
Brugia malayi Uncharacterized LmbE-like protein, COG2120 containing protein 0.0051 0.0072 0.0211
Echinococcus multilocularis UDP glucose 4 epimerase 0.0057 0.0086 0.0184
Trichomonas vaginalis glutaminase, putative 0.0275 0.0573 0.3238
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.06 0.1298 0.2778
Loa Loa (eye worm) Smad1 0.0025 0.0014 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0152 0.0821
Schistosoma mansoni histone deacetylase 1 2 3 0.0317 0.0667 0.1427
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0064 0.0103 0.0539
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0005 0.0014
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0044 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0065 0.0323
Entamoeba histolytica N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative 0.0051 0.0072 0.0406
Echinococcus multilocularis histone deacetylase 3 0.0811 0.177 0.3789
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0005 0.001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0439 0.094 0.2751
Onchocerca volvulus 0.0335 0.0708 0.6206
Mycobacterium tuberculosis Probable lipase LipE 0.0335 0.0708 0.0708
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0005 0.0014
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0063 0.0312
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0003
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0046 0.0063 0.0312
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0002
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.007 0.0355
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0012 0.0066
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.0086 0.0487
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0041 0.005 0.0236
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0016 0.0034
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0016 0.0034
Echinococcus granulosus smad 0.0025 0.0014 0.003
Trypanosoma cruzi Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0041 0.005 0.0236
Brugia malayi Importin beta-1 subunit 0.003 0.0026 0.0075
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.005 0.0239
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.013 0.0278
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0063 0.031
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0005 0.0014
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0046 0.0063 0.0312
Brugia malayi Thioredoxin reductase 0.0134 0.0258 0.0755
Toxoplasma gondii histone deacetylase HDAC4 0.0317 0.0667 0.3739
Schistosoma mansoni smad1 5 8 and 0.0025 0.0014 0.003
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.0086 0.0185
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0008 0.0023
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0012 0.002
Schistosoma mansoni histone deacetylase 4 5 0.0596 0.1289 0.2758
Giardia lamblia DINP protein human, muc B family 0.0064 0.0103 0.0537
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0008 0.0002
Echinococcus multilocularis histone deacetylase 6 0.0636 0.1379 0.2952
Trypanosoma brucei histone deacetylase 3 0.0596 0.1289 0.7267
Echinococcus multilocularis transient receptor potential ion channel A 0.0198 0.04 0.0857
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.007 0.0353
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0041 0.005 0.0239
Brugia malayi GH02984p 0.071 0.1543 0.4517
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0078 0.0134 0.0286
Echinococcus granulosus N acetylglucosaminyl phosphatidylinositol 0.0051 0.0072 0.0154
Leishmania major hypothetical protein, conserved 0.005 0.007 0.0355
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0005 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0335 0.0708 0.3998
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0046 0.0063 0.0134
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0012 0.0034
Schistosoma mansoni transient receptor potential channel 0.0135 0.0261 0.0558
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0005 0.001
Schistosoma mansoni tar DNA-binding protein 0.0076 0.013 0.0278
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.013 0.038
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0012 0.0023
Echinococcus granulosus histone deacetylase 6 0.0596 0.1289 0.2758
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0014 0.003
Onchocerca volvulus 0.0335 0.0708 0.6206
Loa Loa (eye worm) hypothetical protein 0.0083 0.0145 0.0425
Mycobacterium ulcerans DNA polymerase IV 0.0087 0.0152 0.0144
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0001 0.0001
Toxoplasma gondii histone deacetylase HDAC5 0.0317 0.0667 0.3739
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0305 0.0641 0.064
Trypanosoma brucei DNA polymerase IV, putative 0.0087 0.0152 0.0821
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0439 0.094 0.2012
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0008 0.0003
Plasmodium falciparum histone deacetylase, putative 0.0596 0.1289 0.7267
Entamoeba histolytica acetyltransferase, GNAT family 0.0078 0.0132 0.0747
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0005 0.0014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0427 0.0913 0.2673
Brugia malayi UDP galactose 4'-epimerase 0.0057 0.0086 0.0252
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.007 0.0355
Trichomonas vaginalis glucosylceramidase, putative 0.0807 0.176 0.994
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0305 0.0641 0.064
Echinococcus multilocularis thioredoxin glutathione reductase 0.0134 0.0259 0.0554
Brugia malayi Histone deacetylase 1 0.0811 0.177 0.5181
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0046 0.0063 0.0312
Toxoplasma gondii NADPH-glutathione reductase 0.0046 0.0063 0.0312
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0012 0.0023
Plasmodium falciparum histone deacetylase 1 0.0811 0.177 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0062 0.0305
Mycobacterium tuberculosis Probable lipase LipD 0.0335 0.0708 0.0708
Loa Loa (eye worm) RNA binding protein 0.0076 0.013 0.038
Echinococcus granulosus histone acetyltransferase KAT2B 0.028 0.0584 0.1249
Treponema pallidum NADH oxidase 0.0046 0.0063 0.4484
Mycobacterium ulcerans beta-lactamase 0.0335 0.0708 0.07
Loa Loa (eye worm) hypothetical protein 0.0319 0.0672 0.1965
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0305 0.0641 0.064
Loa Loa (eye worm) hypothetical protein 0.005 0.0071 0.0208
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0335 0.0708 0.2071
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.005 0.0281
Trichomonas vaginalis glucosylceramidase, putative 0.0807 0.176 0.994
Brugia malayi CXXC zinc finger family protein 0.0066 0.0106 0.0309
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.0086 0.0252
Brugia malayi MH1 domain containing protein 0.0025 0.0014 0.0041
Brugia malayi Disco-interacting protein 2 homolog 0.0042 0.0054 0.0157
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.005 0.0145
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0005 0.001
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0041 0.005 0.0239
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0024
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0042 0.0054 0.0115
Toxoplasma gondii thioredoxin reductase 0.0134 0.0258 0.142
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0076 0.0129 0.0276
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0005 0.001
Schistosoma mansoni histone deacetylase 0.0811 0.177 0.3789
Entamoeba histolytica hypothetical protein 0.0112 0.021 0.1187
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0112 0.021 0.045
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.013 1
Trichomonas vaginalis chaperonin, putative 0.0024 0.0012 0.0066
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0013 0.0029
Plasmodium falciparum histone acetyltransferase GCN5 0.0078 0.0132 0.0707
Trichomonas vaginalis D-aminoacylase, putative 0.0335 0.0708 0.3998
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0005 0.0014
Plasmodium falciparum thioredoxin reductase 0.0046 0.0063 0.0312
Schistosoma mansoni inositol transporter 0.0078 0.0134 0.0286
Mycobacterium tuberculosis N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB (GlcNAc-Ins deacetylase) 0.0051 0.0072 0.0065
Mycobacterium ulcerans glutaminase 0.0275 0.0573 0.0566
Trypanosoma cruzi DNA polymerase kappa, putative 0.0087 0.0152 0.0818
Onchocerca volvulus 0.0042 0.0054 0.0472
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0335 0.0708 0.2071
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0008 0.0002
Trypanosoma cruzi UDP-galactose 4-epimerase, putative 0.0057 0.0086 0.0444
Loa Loa (eye worm) hypothetical protein 0.0078 0.0134 0.0391
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0046 0.0063 0.0183
Giardia lamblia Glucosamine-6-phosphate isomerase, putative 0.0051 0.0072 0.0363
Trypanosoma cruzi histone deacetylase 1, putative 0.0811 0.177 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.0246 0.0719
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0102 0.0535
Echinococcus multilocularis histone deacetylase 6 0.0596 0.1289 0.2758
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.0086 0.0185
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0046 0.0063 0.0055
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0018 0.0058
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0051 0.0072 0.0406
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0335 0.0708 0.07
Mycobacterium ulcerans esterase/lipase LipP 0.0335 0.0708 0.07
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0014 0.0041
Loa Loa (eye worm) histone deacetylase 7A 0.0596 0.1289 0.3771
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.0041 0.005 0.0436
Echinococcus multilocularis N acetylglucosaminyl phosphatidylinositol 0.0051 0.0072 0.0154
Schistosoma mansoni histone deacetylase hda2 0.0317 0.0667 0.1427
Loa Loa (eye worm) hypothetical protein 0.0279 0.0581 0.17
Schistosoma mansoni Smad4 0.0025 0.0014 0.003
Brugia malayi latrophilin 2 splice variant baaae 0.0949 0.2078 0.6083
Trypanosoma brucei Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0041 0.005 0.0239
Plasmodium vivax hypothetical protein, conserved 0.0335 0.0708 0.3972
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0022 0.0008 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0063 0.031
Schistosoma mansoni brca1-associated protein (brap2) 0.0041 0.005 0.0106
Echinococcus multilocularis snurportin 1 0.0319 0.0672 0.1438
Brugia malayi MH2 domain containing protein 0.0025 0.0014 0.0041
Echinococcus granulosus sodium:glucose cotransporter 2 0.0078 0.0134 0.0286
Onchocerca volvulus 0.0335 0.0708 0.6206
Onchocerca volvulus 0.0078 0.0134 0.1173
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0041 0.005 0.0106
Schistosoma mansoni hypothetical protein 0.0022 0.0009 0.0019
Brugia malayi beta-lactamase 0.0335 0.0708 0.2071
Brugia malayi beta-lactamase family protein 0.0335 0.0708 0.2071
Brugia malayi RNA, U transporter 1 0.0085 0.0149 0.0436
Trichomonas vaginalis glucosylceramidase, putative 0.0807 0.176 0.994
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0008 0.0023
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0071 0.0152
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0152 0.0821
Onchocerca volvulus Glucosylceramidase homolog 0.0529 0.114 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0046 0.0063 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0001 0.0001
Schistosoma mansoni cpg binding protein 0.0069 0.0114 0.0244
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0807 0.176 0.515
Plasmodium vivax N-acetylglucosaminylphosphatidylinositol deacetylase, putative 0.0051 0.0072 0.0365
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0005 0.001
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0041 0.005 0.0106
Schistosoma mansoni ran 0.0022 0.0008 0.0017
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0016 0.0048
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.0041 0.005 0.0239
Trichomonas vaginalis glucosylceramidase, putative 0.0807 0.176 0.994
Trichomonas vaginalis esterase, putative 0.0335 0.0708 0.3998
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0005 0.001
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0012 0.0025
Plasmodium vivax histone deacetylase 2, putative 0.0596 0.1289 0.7267
Brugia malayi glutaminase DH11.1 0.0275 0.0573 0.1677
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.013 0.0278
Echinococcus granulosus solute carrier family 5 0.0078 0.0134 0.0286
Entamoeba histolytica hypothetical protein 0.0112 0.021 0.1187
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0005 0.0014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0335 0.0708 0.0708
Trichomonas vaginalis glutathione reductase, putative 0.0046 0.0063 0.0353
Brugia malayi hypothetical protein 0.0086 0.015 0.044
Loa Loa (eye worm) hypothetical protein 0.0047 0.0065 0.0189
Plasmodium vivax glutathione reductase, putative 0.0134 0.0258 0.142
Echinococcus multilocularis tar DNA binding protein 0.0076 0.013 0.0278
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0012 0.0034
Echinococcus multilocularis smad 0.0025 0.0014 0.003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0005 0.001
Brugia malayi Bromodomain containing protein 0.0048 0.0065 0.0191
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.1206 0.2581
Mycobacterium tuberculosis Conserved protein 0.0335 0.0708 0.0708
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0063 0.031
Echinococcus multilocularis solute carrier family 5 0.0078 0.0134 0.0286
Leishmania major GTP-binding protein, putative 0.0022 0.0008 0.0003
Brugia malayi glutathione reductase 0.0134 0.0258 0.0755
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0005 0.001
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.005 0.0145
Toxoplasma gondii hypothetical protein 0.0093 0.0167 0.0906
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0103 0.0539
Brugia malayi beta-lactamase family protein 0.0335 0.0708 0.2071
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0014 0.0041
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0046 0.0063 0.0312
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0041 0.005 0.0239
Schistosoma mansoni zinc finger protein 0.0029 0.0025 0.0053
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0022 0.0008 0.0043
Toxoplasma gondii exonuclease III APE 0.0022 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.0949 0.2078 0.6083
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0012 0.0034
Echinococcus granulosus histone deacetylase 7 0.0596 0.1289 0.2758
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0335 0.0708 0.2071
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0008 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0005 0.0014
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0041 0.005 0.0145
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0012 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0005 0.0014
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0046 0.0062 0.0307
Leishmania major histone deacetylase, putative 0.0811 0.177 1
Loa Loa (eye worm) hypothetical protein 0.0335 0.0708 0.2071
Loa Loa (eye worm) histone deacetylase 3 0.0811 0.177 0.5181
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0014 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0005 0.0014
Echinococcus granulosus short transient receptor potential channel 6 0.0135 0.0261 0.0558
Brugia malayi RNA binding protein 0.0076 0.013 0.038
Leishmania major DNA polymerase kappa, putative 0.0064 0.0103 0.0539
Mycobacterium ulcerans mycothiol conjugate amidase Mca 0.4498 1 1
Plasmodium falciparum glutathione reductase 0.0046 0.0063 0.0312
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0071 0.0064
Leishmania major hypothetical protein, conserved 0.0041 0.005 0.0239
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0046 0.0063 0.0312
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0439 0.094 0.2751
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0063 0.031
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.013 0.0122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0005 0.001
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0026 0.0103
Giardia lamblia NADH oxidase lateral transfer candidate 0.0046 0.0063 0.031
Trypanosoma cruzi histone deacetylase 1, putative 0.0811 0.177 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.013 0.0693
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0427 0.0913 0.2673
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0005 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0005 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0335 0.0708 0.3971
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0063 0.0315
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.0041 0.005 0.0145
Plasmodium vivax thioredoxin reductase, putative 0.0134 0.0258 0.142
Trypanosoma brucei unspecified product 0.0039 0.0047 0.0222
Brugia malayi ImpB/MucB/SamB family protein 0.0085 0.0149 0.0437
Toxoplasma gondii hypothetical protein 0.0026 0.0018 0.0058
Trypanosoma brucei N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase 0.0051 0.0072 0.0365
Schistosoma mansoni glutaminase 0.0275 0.0573 0.1227
Schistosoma mansoni cpg binding protein 0.0069 0.0114 0.0244
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.0136 0.0728
Loa Loa (eye worm) transcription factor SMAD2 0.0361 0.0764 0.2236
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0012 0.0025
Schistosoma mansoni hypothetical protein 0.0319 0.0672 0.1438
Echinococcus multilocularis importin subunit beta 1 0.003 0.0026 0.0055
Mycobacterium tuberculosis Possible penicillin-binding protein 0.2143 0.4742 0.4792
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0427 0.0913 0.1955
Echinococcus granulosus tar DNA binding protein 0.0076 0.013 0.0278
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0335 0.0708 0.2071
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0005 0.001
Trypanosoma cruzi Ring finger domain/Zn-finger in ubiquitin-hydrolases and other protein, putative 0.0041 0.005 0.0236
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0063 0.0312
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0051 0.0072 0.0406
Echinococcus multilocularis high affinity choline transporter 1 0.071 0.1543 0.3304
Trichomonas vaginalis glucosylceramidase, putative 0.0529 0.114 0.6442
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0087 0.0154 0.0828
Schistosoma mansoni ap endonuclease 0.0022 0.0008 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0112 0.021 0.045
Schistosoma mansoni hypothetical protein 0.0022 0.0008 0.0017
Mycobacterium leprae conserved hypothetical protein 0.0335 0.0708 0.0691
Loa Loa (eye worm) hypothetical protein 0.0021 0.0005 0.0014
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0005 0.001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1389 0.3059 0.8953
Trypanosoma brucei histone deacetylase 2 0.0317 0.0667 0.3739
Echinococcus multilocularis dna polymerase kappa 0.0087 0.0152 0.0326
Echinococcus granulosus sodium:glucose cotransporter 0.0078 0.0134 0.0286
Echinococcus granulosus sodium:myo inositol cotransporter 0.0078 0.0134 0.0286
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.007 0.0355
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0119 0.0256
Trichomonas vaginalis glucosylceramidase, putative 0.0529 0.114 0.6442
Echinococcus multilocularis cpg binding protein 0.0069 0.0114 0.0244
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0078 0.0134 0.0286
Giardia lamblia Histone deacetylase 0.0811 0.177 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0041 0.005 0.0236
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0335 0.0708 0.1515
Brugia malayi Sodium:solute symporter family protein 0.0078 0.0134 0.0391
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0335 0.0708 0.0708
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0034 0.0035 0.0103
Echinococcus granulosus short transient receptor potential channel 6 0.0135 0.0261 0.0558
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0005 0.001
Mycobacterium ulcerans lipase LipD 0.0335 0.0708 0.07
Echinococcus granulosus histone deacetylase 0.0596 0.1289 0.2758
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0013 0.0074
Loa Loa (eye worm) histone deacetylase 1 0.0811 0.177 0.5181
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.007 0.0355
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0005 0.0014
Trichomonas vaginalis histone deacetylase, putative 0.0811 0.177 1
Trypanosoma brucei hypothetical protein, conserved 0.0335 0.0708 0.3972
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0087 0.0154 0.0828
Schistosoma mansoni histone deacetylase 4 5 0.0596 0.1289 0.2758
Echinococcus granulosus disco interacting protein 2 0.0042 0.0054 0.0115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0063 0.031
Loa Loa (eye worm) hypothetical protein 0.0317 0.0667 0.1951
Echinococcus granulosus beta LACTamase domain containing family member 0.0335 0.0708 0.1515
Echinococcus granulosus UDP glucose 4 epimerase 0.0057 0.0086 0.0184
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0016 0.0034
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0008 0.0024
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0063 0.031
Trichomonas vaginalis BRCA1-associated protein, putative 0.0041 0.005 0.0281
Brugia malayi Calcitonin receptor-like protein seb-1 0.1389 0.3059 0.8953
Mycobacterium ulcerans hypothetical protein 0.0335 0.0708 0.07
Leishmania major histone deacetylase, putative 0.0596 0.1289 0.7267
Loa Loa (eye worm) hypothetical protein 0.1549 0.3417 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0095 0.0204
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0005 0.001
Mycobacterium tuberculosis Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) 0.4447 0.9887 1
Leishmania major histone deacetylase, putative 0.0596 0.1289 0.7267
Schistosoma mansoni N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase 0.0051 0.0072 0.0154
Loa Loa (eye worm) MH2 domain-containing protein 0.0361 0.0764 0.2236
Trichomonas vaginalis NAD dependent epimerase/dehydratase, putative 0.0057 0.0086 0.0487
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0063 0.031
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.1206 0.2581
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0071 0.0064
Onchocerca volvulus Histone deacetylase 10 homolog 0.0317 0.0667 0.5846
Echinococcus granulosus snurportin 1 0.0319 0.0672 0.1438
Trichomonas vaginalis penicillin-binding protein, putative 0.0335 0.0708 0.3998
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0339 0.0717 0.0717
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.1206 0.2581
Schistosoma mansoni hypothetical protein 0.0439 0.094 0.2012
Trichomonas vaginalis penicillin-binding protein, putative 0.0335 0.0708 0.3998
Plasmodium falciparum importin beta, putative 0.003 0.0026 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0087 0.0152 0.0821
Toxoplasma gondii ABC1 family protein 0.0335 0.0708 0.3972
Mycobacterium leprae Probable lipase LipE 0.0335 0.0708 0.0691
Trichomonas vaginalis histone deacetylase, putative 0.0811 0.177 1
Echinococcus granulosus transient receptor potential gamma protein 0.0204 0.0415 0.0889
Echinococcus multilocularis disco interacting protein 2 0.0042 0.0054 0.0115
Schistosoma mansoni high-affinity choline transporter 0.071 0.1543 0.3304

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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