Detailed information for compound 1279754

Basic information

Technical information
  • TDR Targets ID: 1279754
  • Name: N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]- 2-propoxybenzamide
  • MW: 402.509 | Formula: C24H22N2O2S
  • H donors: 1 H acceptors: 2 LogP: 6.11 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccccc1C(=O)Nc1ccc(cc1)c1nc2c(s1)cc(cc2)C
  • InChi: 1S/C24H22N2O2S/c1-3-14-28-21-7-5-4-6-19(21)23(27)25-18-11-9-17(10-12-18)24-26-20-13-8-16(2)15-22(20)29-24/h4-13,15H,3,14H2,1-2H3,(H,25,27)
  • InChiKey: ICWVKBKVEZTROK-UHFFFAOYSA-N  


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Synonyms

  • N-[4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]-2-propoxy-benzamide
  • NCGC00103054-01
  • ALD-N012838
  • ARONIS011818

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0222 0.523 1
Loa Loa (eye worm) TAR-binding protein 0.0128 0.2843 0.4142
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.1774 0.3338
Brugia malayi cathepsin L-like precursor 0.0025 0.0188 0.0213
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0188 0.0281
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0055 0.0956 0.0917
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0032 0.0371 0.3356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Brugia malayi Cathepsin L-like precursor 0.0037 0.05 0.0671
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.05 0.0882
Echinococcus granulosus cathepsin l1 0.0037 0.05 0.046
Onchocerca volvulus 0.0037 0.05 0.3479
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0055 0.0956 0.0917
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0152
Echinococcus granulosus cathepsin L cysteine proteinase 0.0037 0.05 0.046
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0032 0.0371 0.3364
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0032 0.0371 0.3356
Onchocerca volvulus Peroxidase homolog 0.0026 0.0209 0.0237
Onchocerca volvulus Cathepsin F homolog 0.0037 0.05 0.3479
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0032 0.0371 0.3356
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0075 0.0033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0188 0.0274
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0032 0.0371 0.3364
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.05 0.0882
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0956 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0289 0.0421
Brugia malayi Peroxidasin 0.0026 0.0209 0.0245
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0289 0.2441
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0075 0.0063
Brugia malayi hypothetical protein 0.0286 0.6865 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0032 0.0371 0.3364
Brugia malayi TAR-binding protein 0.0128 0.2843 0.4105
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0104 0.0328
Schistosoma mansoni hypothetical protein 0.0032 0.0371 0.0632
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0209 0.0305
Loa Loa (eye worm) hypothetical protein 0.0029 0.0289 0.0421
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.208 0.2986
Onchocerca volvulus Peroxidase homolog 0.0026 0.0209 0.0237
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0083 0.1677 0.1642
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0087 0.1774 0.1739
Mycobacterium ulcerans hypothetical protein 0.0029 0.0289 0.2432
Loa Loa (eye worm) hypothetical protein 0.0037 0.05 0.0729
Brugia malayi Blistered cuticle protein 3 0.0026 0.0209 0.0245
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0222 0.523 0.7618
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.05 0.0882
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0289 0.2432
Onchocerca volvulus 0.0058 0.1047 0.9578
Schistosoma mansoni cellular tumor antigen P53 0.006 0.1085 0.201
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0032 0.0371 0.3356
Onchocerca volvulus 0.0037 0.05 0.3479
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0222 0.523 1
Echinococcus multilocularis cysteine protease 0.0037 0.05 0.046
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0104 0.0339
Echinococcus multilocularis peroxidasin 0.0026 0.0209 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0188 0.0281
Leishmania major cathepsin L-like protease 0.0037 0.05 0.0825
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0956 0.176
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0037 0.05 0.0729
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.05 0.0882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1282 0.1816
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.6865 0.6852
Leishmania major cytochrome p450-like protein 0.0049 0.0814 0.1434
Leishmania major cytochrome p450-like protein 0.0032 0.0371 0.0573
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0032 0.0371 0.3364
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0289 0.2441
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0814 0.1186
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0289 0.0475
Schistosoma mansoni peroxidasin 0.0026 0.0209 0.0322
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0032 0.0371 0.3356
Toxoplasma gondii cathepsin CPL 0.0037 0.05 0.0825
Schistosoma mansoni ap endonuclease 0.002 0.0075 0.0063
Plasmodium falciparum cysteine proteinase falcipain 3 0.0037 0.05 0.0882
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0209 0.0237
Mycobacterium leprae Conserved hypothetical protein 0.0032 0.0371 1
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0222 0.523 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Entamoeba histolytica cysteine protease, putative 0.0037 0.05 0.0882
Toxoplasma gondii cytochrome p450 superfamily protein 0.0032 0.0371 0.0573
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0222 0.523 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0075 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0188 0.0274
Trypanosoma cruzi cytochrome P450, putative 0.0049 0.0814 0.1487
Leishmania major cathepsin L-like protease 0.0037 0.05 0.0825
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.05 0.0882
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.05 0.046
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0032 0.0371 0.3364
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.05 0.0882
Brugia malayi hypothetical protein 0.0043 0.0668 0.0917
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0222 0.523 1
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0222 0.523 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.208 0.2986
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.05 0.046
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0222 0.523 0.5209
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.05 0.0882
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Leishmania major cysteine peptidase A (CPA) 0.0037 0.05 0.0825
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0032 0.0371 0.0632
Loa Loa (eye worm) cytochrome P450 family protein 0.009 0.1863 0.2713
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0032 0.0371 0.3356
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Echinococcus granulosus cytochrome P450 2K1 0.0032 0.0371 0.0329
Brugia malayi Cathepsin L-like cysteine proteinase 0.0025 0.0188 0.0213
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0209 0.0237
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0032 0.0371 0.3356
Onchocerca volvulus 0.0037 0.05 0.3479
Leishmania major cathepsin L-like protease 0.0037 0.05 0.0825
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0371 0.0632
Trypanosoma cruzi cruzipain precursor, putative 0.0037 0.05 0.0882
Loa Loa (eye worm) hypothetical protein 0.0031 0.0355 0.0517
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0075 0.5
Plasmodium vivax vivapain-2 0.0037 0.05 0.0882
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0104 0.5
Echinococcus multilocularis GPCR, family 2 0.0031 0.0355 0.0314
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0032 0.0371 0.3356
Leishmania major cytochrome p450-like protein 0.0032 0.0371 0.0573
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.05 0.0882
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Echinococcus granulosus cathepsin l cysteine peptidase 0.0037 0.05 0.046
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0222 0.523 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0055 0.0956 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0037 0.05 0.0882
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0032 0.0371 0.3356
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0032 0.0371 0.3364
Schistosoma mansoni hypothetical protein 0.0031 0.0355 0.0602
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0956 0.176
Brugia malayi Cytochrome P450 family protein 0.009 0.1863 0.2668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Brugia malayi Cytochrome P450 family protein 0.0049 0.0814 0.1131
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0355 0.0314
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0289 0.0415
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0209 0.0245
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0032 0.0371 0.0632
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0032 0.0371 0.3364
Onchocerca volvulus 0.0026 0.0209 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0032 0.0371 0.3356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0032 0.0371 0.3356
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0075 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2843 0.54
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.05 0.0882
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0209 0.0245
Echinococcus multilocularis potassium voltage gated channel protein 0.0087 0.1774 0.1739
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0222 0.523 0.7618
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0668 0.0628
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0032 0.0371 0.3356
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0104 0.0118
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0289 0.2432
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0289 0.0361
Schistosoma mansoni voltage-gated potassium channel 0.0087 0.1774 0.3338
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0032 0.0371 0.3356
Echinococcus granulosus potassium voltage gated channel protein 0.0087 0.1774 0.1739
Echinococcus multilocularis tumor protein p63 0.0408 1 1
Brugia malayi Cathepsin L-like precursor 0.0037 0.05 0.0671
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0032 0.0371 0.3356
Loa Loa (eye worm) CYP4Cod1 0.0049 0.0814 0.1186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0032 0.0371 0.3356
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0032 0.0371 0.3356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.05 0.0882
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0032 0.0371 0.0573
Schistosoma mansoni hypothetical protein 0.0031 0.0355 0.0602
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0371 0.0632
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.05 0.0882
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0032 0.0371 0.3364
Schistosoma mansoni hypothetical protein 0.0031 0.0355 0.0602
Onchocerca volvulus 0.0026 0.0209 0.0237
Onchocerca volvulus Cathepsin L homolog 0.0037 0.05 0.3479
Loa Loa (eye worm) cysteine protease 0.0037 0.05 0.0729
Loa Loa (eye worm) RNA binding protein 0.0128 0.2843 0.4142
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0289 0.2432
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.05 0.0882
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.05 0.0882
Schistosoma mansoni hypothetical protein 0.0058 0.1047 0.1937
Loa Loa (eye worm) ctsf protein 0.0037 0.05 0.0729
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0956 1
Leishmania major cathepsin L-like protease 0.0037 0.05 0.0825
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0075 0.0048
Leishmania major cathepsin L-like protease 0.0037 0.05 0.0825
Leishmania major cathepsin L-like protease 0.0037 0.05 0.0825
Schistosoma mansoni peroxidasin 0.0026 0.0209 0.0322
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.05 0.0671
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2843 0.54
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0032 0.0371 0.3364
Onchocerca volvulus 0.0037 0.05 0.3479
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.05 0.0882
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.05 0.0882
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0104 0.0118
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0032 0.0371 0.3356
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.6865 0.6852
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0152
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0668 0.1206
Leishmania major cathepsin L-like protease 0.0037 0.05 0.0825
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0152
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.05 0.046
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0289 0.0475
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0289 0.0361
Echinococcus multilocularis tar DNA binding protein 0.0128 0.2843 0.2813
Brugia malayi cytochrome P450 0.0032 0.0371 0.0481
Brugia malayi Cathepsin L-like precursor 0.0037 0.05 0.0671
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.05 0.0882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0222 0.523 0.5209
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0209 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0188 0.0281
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0032 0.0371 0.3364
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0355 0.0314
Mycobacterium leprae putative cytochrome p450 0.0032 0.0371 1
Schistosoma mansoni cytochrome P450 0.0032 0.0371 0.0632
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.05 0.0882
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0032 0.0371 0.3356
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0032 0.0371 0.3356
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0355 0.0314
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0289 0.0475
Brugia malayi Cathepsin L-like precursor 0.0025 0.0188 0.0213
Brugia malayi Cathepsin L-like precursor 0.0037 0.05 0.0671
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0032 0.0371 0.3364
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.05 0.0729
Loa Loa (eye worm) cytochrome P450 0.0032 0.0371 0.054
Leishmania major cathepsin L-like protease 0.0037 0.05 0.0825
Entamoeba histolytica hypothetical protein 0.0043 0.0668 0.1206
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0075 0.0063
Schistosoma mansoni hypothetical protein 0.0031 0.0355 0.0602
Onchocerca volvulus 0.0037 0.05 0.3479
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0025 0.0188 0.0281
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0289 0.2432
Brugia malayi hypothetical protein 0.0026 0.0209 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.05 0.0882
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2843 0.54
Entamoeba histolytica hypothetical protein 0.0043 0.0668 0.1206
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0049 0.0814 0.8394
Onchocerca volvulus 0.0037 0.05 0.3479
Loa Loa (eye worm) hypothetical protein 0.0099 0.208 0.303
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.05 0.046
Brugia malayi Cytochrome P450 family protein 0.0032 0.0371 0.0481
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0209 0.0305
Brugia malayi Cytochrome P450 family protein 0.0049 0.0814 0.1131
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0075 0.0063
Trypanosoma brucei cytochrome P450, putative 0.0049 0.0814 0.1487
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0289 0.0415
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0289 0.0415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.05 0.0882
Loa Loa (eye worm) hypothetical protein 0.006 0.1085 0.1581
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0222 0.523 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0075 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2843 0.54
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0668 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.05 0.0882
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0355 0.0314
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.05 0.0882
Echinococcus granulosus cathepsin l1 0.0025 0.0188 0.0146
Echinococcus granulosus GPCR family 2 0.0031 0.0355 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Loa Loa (eye worm) hypothetical protein 0.0067 0.1282 0.1867
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0209 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Loa Loa (eye worm) hypothetical protein 0.0025 0.0188 0.0274
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0032 0.0371 0.3364
Loa Loa (eye worm) hypothetical protein 0.0087 0.1774 0.2585
Schistosoma mansoni hypothetical protein 0.0043 0.0668 0.1206
Entamoeba histolytica hypothetical protein 0.0043 0.0668 0.1206
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0032 0.0371 0.3364
Echinococcus granulosus peroxidasin 0.0026 0.0209 0.0168
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0289 0.0361
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0087 0.1774 0.2538
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0209 0.0245
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.05 0.0882
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.2843 0.4142
Schistosoma mansoni hypothetical protein 0.0067 0.1282 0.2388
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.05 0.0882
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0289 0.2432
Onchocerca volvulus 0.006 0.1085 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.05 0.0882
Entamoeba histolytica hypothetical protein 0.0043 0.0668 0.1206
Brugia malayi Cathepsin L-like precursor 0.0037 0.05 0.0671
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0032 0.0371 0.3364
Toxoplasma gondii aldehyde dehydrogenase 0.0055 0.0956 0.1708
Brugia malayi Cathepsin L-like precursor 0.0025 0.0188 0.0213
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0032 0.0371 0.3356
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0032 0.0371 0.3364
Loa Loa (eye worm) hypothetical protein 0.0029 0.0289 0.0421
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.05 0.0882
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0289 0.2432
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0032 0.0371 0.3364
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0355 0.0458
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0032 0.0371 0.3364
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.05 0.0882
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0222 0.523 0.7603
Trypanosoma cruzi cytochrome P450, putative 0.0049 0.0814 0.1487
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0055 0.0956 0.1708
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Brugia malayi Cathepsin L-like precursor 0.0037 0.05 0.0671
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0814 0.1186
Echinococcus granulosus tar DNA binding protein 0.0128 0.2843 0.2813
Onchocerca volvulus 0.0029 0.0289 0.1126
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0355 0.0517
Brugia malayi RNA binding protein 0.0128 0.2843 0.4105
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0209 0.0237
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0209 0.0237
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0956 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0032 0.0371 0.3364
Echinococcus multilocularis cysteine protease 0.0037 0.05 0.046
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0222 0.523 1
Onchocerca volvulus Cathepsin L homolog 0.0037 0.05 0.3479
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0209 0.0245
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0032 0.0371 0.3364
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.2843 0.4105
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0037 0.05 0.0882
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.05 0.0882
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0355 0.0458
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1047 0.1472
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0075 0.0109
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0222 0.523 0.7603
Loa Loa (eye worm) fibroinase 0.0037 0.05 0.0729
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.208 0.303
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0075 0.0063
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0209 0.0305
Plasmodium vivax vivapain-2 0.0037 0.05 0.0882
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.05 0.0882
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0075 0.0063
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0289 0.2432
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0075 0.0033
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0209 0.0245
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0075 0.5
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0222 0.523 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0305
Schistosoma mansoni ap endonuclease 0.002 0.0075 0.0063
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0032 0.0371 0.3364
Loa Loa (eye worm) hypothetical protein 0.0286 0.6865 1
Echinococcus multilocularis 0.0032 0.0371 0.0329
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.05 0.0882
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0075 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.05 0.0882
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0152
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0222 0.523 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.1047 0.1937
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0075 0.0063
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0188 0.0281
Onchocerca volvulus 0.0037 0.05 0.3479
Onchocerca volvulus 0.0026 0.0209 0.0237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0037 0.05 0.0882
Schistosoma mansoni tar DNA-binding protein 0.0128 0.2843 0.54

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 4.7755 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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