Detailed information for compound 1297989

Basic information

Technical information
  • TDR Targets ID: 1297989
  • Name: N-[2-(morpholine-4-carbonyl)phenyl]pyridine-4 -carboxamide
  • MW: 311.335 | Formula: C17H17N3O3
  • H donors: 1 H acceptors: 3 LogP: 1.32 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccncc1)Nc1ccccc1C(=O)N1CCOCC1
  • InChi: 1S/C17H17N3O3/c21-16(13-5-7-18-8-6-13)19-15-4-2-1-3-14(15)17(22)20-9-11-23-12-10-20/h1-8H,9-12H2,(H,19,21)
  • InChiKey: YADDZINAHHQXQU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(morpholino-oxomethyl)phenyl]-4-pyridinecarboxamide
  • N-[2-(morpholine-4-carbonyl)phenyl]isonicotinamide
  • N-(2-morpholin-4-ylcarbonylphenyl)pyridine-4-carboxamide
  • BIM-0044509.P001
  • AP-064/11562416
  • MLS000109827
  • SMR000105764
  • Oprea1_191003
  • N-[2-(4-morpholinylcarbonyl)phenyl]isonicotinamide
  • STK092930
  • CBMicro_044769
  • ZINC00449089

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi calpain family protein 1 0.006 0.0379 0.0469
Onchocerca volvulus 0.0029 0.0106 0.0114
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0106 0.0106
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0463 0.0463
Brugia malayi MH1 domain containing protein 0.0025 0.0071 0.0088
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0155 0.1226 0.3707
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0017 0.0001 0.0003
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0022 0.0051 0.0153
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Echinococcus multilocularis calpain 5 0.0022 0.0051 0.0051
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0017 0.0001 0.0003
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0041 0.0214 0.0214
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Brugia malayi Serotonin receptor 0.0029 0.0106 0.0131
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0106 0.0106
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0167 0.1331 0.1331
Trichomonas vaginalis ap endonuclease, putative 0.0084 0.0591 0.0641
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0054 0.0054
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.3693 0.3693
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0244 0.4125
Schistosoma mansoni cathepsin D (A01 family) 0.0285 0.2376 0.2376
Trypanosoma brucei RNA editing exonuclease 2 0.0017 0.0001 0.0003
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0302 0.0914
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0313 0.0388
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0053 0.0066
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0074 0.0508 0.0629
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0463 0.0463
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0071 0.0071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0313 0.0313
Mycobacterium tuberculosis Probable peptidase 0.0155 0.1226 0.4163
Echinococcus granulosus 7tm_1 domain containing protein 0.0029 0.0106 0.0106
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0051 0.0153
Brugia malayi CCR4 0.0017 0.0001 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0001 0.0003
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0054 0.0054
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0001 0.0003
Echinococcus granulosus calpain 7 C02 family 0.0022 0.0051 0.0051
Schistosoma mansoni opsin-like receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0047 0.027 0.0334
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0189 0.0189
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0029 0.0106 0.0106
Onchocerca volvulus 0.0029 0.0106 0.0114
Brugia malayi Pepsin A precursor 0.0023 0.0054 0.0067
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0521 0.1574
Schistosoma mansoni amine GPCR 0.0029 0.0106 0.0106
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0041 0.0214 0.0647
Brugia malayi prolyl oligopeptidase family protein 0.0391 0.3308 0.4096
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0029 0.0106 0.0106
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0051 0.0153
Echinococcus multilocularis sex peptide receptor 0.0029 0.0106 0.0106
Brugia malayi G-protein coupled receptor 0.0029 0.0106 0.0131
Schistosoma mansoni smad1 5 8 and 0.0025 0.0071 0.0071
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0017 0.0001 0.0003
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.0106 0.0131
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0001 0.0001
Schistosoma mansoni carbon catabolite repressor protein 0.0017 0.0001 0.0001
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0029 0.0106 0.0106
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0029 0.0106 0.0114
Entamoeba histolytica hypothetical protein 0.0042 0.0224 0.3783
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0302 0.0302
Echinococcus multilocularis acylamino acid releasing enzyme 0.0041 0.0214 0.0214
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0041 0.0214 0.0214
Echinococcus multilocularis allatostatin A receptor 0.0029 0.0106 0.0106
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0106 0.0106
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0017 0.0001 0.0003
Echinococcus granulosus 7TM GPCR rhodopsin 0.0029 0.0106 0.0106
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0041 0.0214 0.0232
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0106 0.0106
Brugia malayi neuropeptide F receptor 0.0029 0.0106 0.0131
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0051 0.0153
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0062 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0155 0.1226 0.3707
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0029 0.0106 0.0106
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0403 0.0403
Leishmania major oligopeptidase b 0.0155 0.1226 0.3707
Leishmania major hypothetical protein, conserved 0.0017 0.0001 0.0003
Brugia malayi prolyl oligopeptidase family protein 0.0041 0.0214 0.0265
Echinococcus multilocularis g-protein coupled receptor 0.0029 0.0106 0.0106
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0051 0.0153
Trypanosoma cruzi oligopeptidase b 0.0155 0.1226 0.3707
Giardia lamblia Alanyl dipeptidyl peptidase 0.0041 0.0214 0.3614
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0134 0.1036 0.3133
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0029 0.0106 0.0131
Schistosoma mansoni ap endonuclease 0.0084 0.0591 0.0591
Echinococcus multilocularis serotonin receptor 0.0029 0.0106 0.0106
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.015 0.0453
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Trichomonas vaginalis rotamase, putative 0.0034 0.015 0.0162
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Brugia malayi MH2 domain containing protein 0.0025 0.0071 0.0088
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Plasmodium vivax aspartyl protease, putative 0.0023 0.0054 0.0522
Schistosoma mansoni bromodomain containing protein 0.0073 0.0497 0.0497
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0084 0.0591 0.1787
Entamoeba histolytica hypothetical protein 0.0042 0.0224 0.3783
Brugia malayi MH2 domain containing protein 0.0365 0.3078 0.3811
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0391 0.3308 0.3308
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0106 0.0106
Schistosoma mansoni ets-related 0.0263 0.2183 0.2183
Onchocerca volvulus 0.0134 0.1036 0.1124
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0041 0.0214 0.0232
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0106 0.0106
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0001 0.0003
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0041 0.0214 0.0214
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.062 0.0767
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0391 0.3308 0.3308
Schistosoma mansoni alpha-1 adrenergic receptor 0.0029 0.0106 0.0106
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0051 0.0153
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0084 0.0591 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Echinococcus multilocularis GPCR, family 2 0.0052 0.0313 0.0313
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0106 0.0106
Brugia malayi CXXC zinc finger family protein 0.003 0.0121 0.015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0084 0.0591 0.1787
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0017 0.0001 0.0013
Brugia malayi acetyltransferase, GNAT family protein 0.0167 0.1331 0.1648
Schistosoma mansoni memapsin-2 (A01 family) 0.0023 0.0054 0.0054
Schistosoma mansoni neuropeptide receptor 0.0029 0.0106 0.0106
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0084 0.0591 0.8349
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0017 0.0001 0.0013
Brugia malayi exodeoxyribonuclease III family protein 0.0084 0.0591 0.0732
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0079 0.0079
Echinococcus granulosus g-protein coupled receptor 0.0029 0.0106 0.0106
Brugia malayi Dopamine receptor protein 1 0.0029 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Brugia malayi Smad1 0.0025 0.0071 0.0088
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0017 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0052 0.0313 0.0313
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0201 0.163 0.163
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0155 0.1226 0.3707
Onchocerca volvulus 0.0029 0.0106 0.0114
Loa Loa (eye worm) hypothetical protein 0.0053 0.0319 0.0395
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0001 0.0001
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0001 0.0003
Echinococcus granulosus calpain 0.0022 0.0051 0.0051
Schistosoma mansoni nocturnin 0.0017 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0051 0.0153
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0051 0.0153
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0464 0.1402
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0017 0.0001 0.0001
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.015 0.2522
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0165 0.131 0.1622
Brugia malayi latrophilin 2 splice variant baaae 0.0113 0.0848 0.1051
Plasmodium falciparum peptidase, putative 0.0041 0.0214 0.3025
Brugia malayi G protein-coupled receptor 0.0029 0.0106 0.0131
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0106 0.0131
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0214 0.3614
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0029 0.0106 0.0106
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0152 0.1197 0.1197
Plasmodium falciparum plasmepsin I 0.0097 0.0708 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0084 0.0591 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0084 0.0591 1
Loa Loa (eye worm) Smad1 0.0025 0.0071 0.0088
Echinococcus multilocularis smad 0.0025 0.0071 0.0071
Echinococcus granulosus allatostatin A receptor 0.0029 0.0106 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0152 0.1197 0.1197
Echinococcus granulosus g protein coupled receptor 0.0029 0.0106 0.0106
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0071 0.0071
Brugia malayi Pre-SET motif family protein 0.0929 0.8076 1
Schistosoma mansoni cpg binding protein 0.0034 0.0155 0.0155
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0097 0.0708 0.0708
Brugia malayi Bromodomain containing protein 0.0085 0.0607 0.0752
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0051 0.0153
Brugia malayi Melatonin receptor type 1A 0.0029 0.0106 0.0131
Echinococcus granulosus orexin receptor type 2 0.0029 0.0106 0.0106
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0084 0.0591 0.0732
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0084 0.0591 1
Brugia malayi hypothetical protein 0.0029 0.0106 0.0131
Trypanosoma cruzi mitochondrial protein 99, putative 0.0017 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Onchocerca volvulus 0.0029 0.0106 0.0114
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0001 0.0001
Brugia malayi Pre-SET motif family protein 0.0134 0.1036 0.1283
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Schistosoma mansoni rotamase 0.0034 0.0157 0.0157
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.0106 0.0131
Schistosoma mansoni hypothetical protein 0.0113 0.0848 0.0848
Schistosoma mansoni hypothetical protein 0.0029 0.0106 0.0106
Echinococcus granulosus expressed protein 0.0034 0.0157 0.0157
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0001 0.0003
Brugia malayi putative neuropeptide receptor 0.0029 0.0106 0.0131
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0084 0.0591 0.5703
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0152 0.0152
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0029 0.0106 0.0106
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0062 0.0403 0.0403
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0521 0.7353
Schistosoma mansoni opsin-like receptor 0.0029 0.0106 0.0106
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0041 0.0214 0.0214
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0071 0.0071
Brugia malayi Ets-domain containing protein 0.0087 0.062 0.0767
Giardia lamblia Alanyl dipeptidyl peptidase 0.0041 0.0214 0.3614
Onchocerca volvulus 0.1058 0.9212 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0017 0.0001 0.0001
Schistosoma mansoni calpain C (C02 family) 0.0022 0.0051 0.0051
Schistosoma mansoni biogenic amine receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0023 0.0054 0.0067
Echinococcus granulosus tm gpcr rhodopsin 0.1049 0.9138 0.9138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Onchocerca volvulus Prolyl endopeptidase homolog 0.0391 0.3308 0.3591
Schistosoma mansoni hypothetical protein 0.0052 0.0313 0.0313
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0051 0.0153
Toxoplasma gondii aspartyl protease ASP3 0.0023 0.0054 0.0163
Loa Loa (eye worm) hypothetical protein 0.0041 0.0214 0.0265
Schistosoma mansoni smad1 5 8 and 0.0025 0.0071 0.0071
Echinococcus granulosus zinc finger protein 0.0027 0.0087 0.0087
Schistosoma mansoni ap endonuclease 0.0084 0.0591 0.0591
Brugia malayi hypothetical protein 0.0029 0.0106 0.0131
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Loa Loa (eye worm) calpain family protein 1 0.006 0.0379 0.0469
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Brugia malayi MH1 domain containing protein 0.0025 0.0071 0.0088
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0302 0.0914
Echinococcus granulosus G protein coupled receptor 139 0.0029 0.0106 0.0106
Echinococcus granulosus histone lysine methyltransferase setb 0.0152 0.1197 0.1197
Loa Loa (eye worm) hypothetical protein 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Schistosoma mansoni cpg binding protein 0.0034 0.0155 0.0155
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0201 0.163 0.2018
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Echinococcus granulosus acylamino acid releasing enzyme 0.0041 0.0214 0.0214
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0051 0.0153
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0022 0.0051 0.0153
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0167 0.1331 0.1331
Toxoplasma gondii exonuclease III APE 0.0084 0.0591 0.1787
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0106 0.0106
Plasmodium falciparum plasmepsin VI 0.0097 0.0708 1
Entamoeba histolytica hypothetical protein 0.0042 0.0224 0.3783
Leishmania major pantothenate kinase subunit, putative 0.0017 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0022 0.0045 0.0045
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0029 0.0106 0.0106
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0313 0.0313
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0214 0.3614
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1049 0.9138 0.9138
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Onchocerca volvulus 0.0023 0.0054 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Schistosoma mansoni biogenic amine receptor 0.0029 0.0106 0.0106
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0302 0.0327
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0071 0.0088
Loa Loa (eye worm) hypothetical protein 0.0041 0.0212 0.0262
Echinococcus granulosus peptide allatostatin:somatostatin 0.0029 0.0106 0.0106
Echinococcus multilocularis serotonin receptor 0.0029 0.0106 0.0106
Schistosoma mansoni neuropeptide receptor 0.0029 0.0106 0.0106
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.0165 0.131 0.1622
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0214 0.0232
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Loa Loa (eye worm) prolyl oligopeptidase 0.0041 0.0214 0.0265
Leishmania major RNA-editing complex protein MP100, putative 0.0017 0.0001 0.0003
Echinococcus granulosus Dipeptidyl peptidase 9 0.0041 0.0214 0.0214
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0106 0.0106
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0106 0.0106
Brugia malayi hypothetical protein 0.0029 0.0106 0.0131
Schistosoma mansoni synaptojanin 0.0017 0.0001 0.0001
Echinococcus granulosus synaptojanin 1 0.0017 0.0001 0.0001
Brugia malayi AKH receptor 0.0029 0.0106 0.0131
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0001 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0106 0.0106
Schistosoma mansoni cript-related 0.0017 0.0001 0.0001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0106 0.0106
Trichomonas vaginalis rotamase, putative 0.0034 0.0157 0.0169
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.0106 0.0131
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0001 0.0001
Echinococcus granulosus neuropeptide s receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.0106 0.0131
Plasmodium falciparum plasmepsin III 0.0023 0.0054 0.0764
Brugia malayi G-protein coupled receptor 0.0029 0.0106 0.0131
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0084 0.0591 0.1787
Schistosoma mansoni smad 0.0025 0.0071 0.0071
Loa Loa (eye worm) aspartyl protease 6 0.0023 0.0054 0.0067
Schistosoma mansoni amine GPCR 0.0029 0.0106 0.0106
Trypanosoma brucei oligopeptidase b 0.0155 0.1226 0.3707
Echinococcus multilocularis calpain A 0.0062 0.0403 0.0403
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0051 0.0051
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0214 0.2066
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0017 0.0001 0.0003
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0051 0.0153
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0106 0.0106
Onchocerca volvulus 0.0029 0.0106 0.0114
Echinococcus granulosus GPCR family 2 0.0052 0.0313 0.0313
Echinococcus granulosus neuropeptide FF receptor 2 0.0029 0.0106 0.0106
Leishmania major hypothetical protein, conserved 0.0017 0.0001 0.0003
Mycobacterium tuberculosis Probable exported protein 0.0017 0.0001 0.0003
Brugia malayi hypothetical protein 0.0029 0.0106 0.0131
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0017 0.0001 0.0001
Toxoplasma gondii aspartyl protease 0.0023 0.0054 0.0163
Brugia malayi ORL1-like opioid receptor 0.0029 0.0106 0.0131
Brugia malayi calpain family protein 1 0.006 0.0379 0.0469
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0017 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0106 0.0106
Echinococcus granulosus calpain 5 0.0022 0.0051 0.0051
Leishmania major hypothetical protein, conserved 0.0076 0.0521 0.1574
Leishmania major hypothetical protein, conserved 0.0017 0.0001 0.0003
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0106 0.0106
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0313 0.0388
Schistosoma mansoni amine GPCR 0.0029 0.0106 0.0106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0201 0.163 0.163
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0521 0.7353
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.062 0.062
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0017 0.0001 0.0003
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0017 0.0001 0.0003
Onchocerca volvulus 0.0029 0.0106 0.0114
Plasmodium falciparum plasmepsin II 0.0097 0.0708 1
Schistosoma mansoni neuropeptide receptor 0.0029 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0017 0.0001 0.0001
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0097 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0152 0.1197 0.1482
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0017 0.0001 0.0001
Echinococcus granulosus Smad4 0.0025 0.0071 0.0071
Brugia malayi hypothetical protein 0.0076 0.0521 0.0645
Echinococcus granulosus alpha 1A adrenergic receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) prolyl oligopeptidase 0.0041 0.0214 0.0265
Brugia malayi Bromodomain containing protein 0.0045 0.0247 0.0306
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.0106 0.0131
Echinococcus granulosus dnaJ subfamily B 0.0434 0.3693 0.3693
Brugia malayi PHD-finger family protein 0.0032 0.0137 0.0169
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0244 0.3452
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Brugia malayi Eukaryotic aspartyl protease family protein 0.0023 0.0054 0.0067
Onchocerca volvulus 0.003 0.0121 0.0131
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0012 0.0012
Schistosoma mansoni biogenic amine receptor 0.0029 0.0106 0.0106
Plasmodium vivax exodeoxyribonuclease III, putative 0.0017 0.0001 0.0009
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0071 0.0071
Echinococcus granulosus hypothetical protein 0.0029 0.0106 0.0106
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0521 0.1574
Loa Loa (eye worm) hypothetical protein 0.0052 0.0313 0.0388
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0302 0.0327
Entamoeba histolytica prolyl oligopeptidase family protein 0.0041 0.0214 0.3614
Schistosoma mansoni histamine h1 receptor 0.0029 0.0106 0.0106
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) calpain 0.0022 0.0051 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0155 0.1226 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0041 0.0214 0.3614
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0054 0.0054
Echinococcus multilocularis neuropeptide FF receptor 2 0.0029 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0029 0.0106 0.0106
Echinococcus multilocularis G-protein coupled receptor, putative 0.0029 0.0106 0.0106
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0313 0.0388
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0929 0.8076 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0084 0.0591 0.0591
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0391 0.3308 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0029 0.0106 0.0106
Loa Loa (eye worm) acetyltransferase 0.0167 0.1331 0.1648
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.0106 0.0131
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.1147 1 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0029 0.0106 0.0106
Brugia malayi Dopamine receptor protein 2 0.0029 0.0106 0.0131
Entamoeba histolytica hypothetical protein 0.0042 0.0224 0.3783
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0521 0.1574
Echinococcus granulosus traf and tnf receptor associated protein 0.0017 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0106 0.0106
Echinococcus multilocularis orexin receptor type 2 0.0029 0.0106 0.0106
Echinococcus granulosus smad 0.0025 0.0071 0.0071
Brugia malayi prolyl oligopeptidase family protein 0.0041 0.0214 0.0265
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Schistosoma mansoni adenoreceptor 0.0029 0.0106 0.0106
Echinococcus granulosus calpain A 0.0062 0.0403 0.0403
Loa Loa (eye worm) calpain family protein 1 0.0044 0.024 0.0297
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0201 0.163 0.163
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0041 0.0214 0.0647
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0051 0.0153
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Echinococcus granulosus somatostatin receptor 0.0029 0.0106 0.0106
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0157 0.0194
Schistosoma mansoni hypothetical protein 0.0034 0.0152 0.0152
Brugia malayi neuropeptide F receptor 0.0029 0.0106 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0106 0.0106
Onchocerca volvulus 0.0029 0.0106 0.0114
Schistosoma mansoni hypothetical protein 0.0434 0.3693 0.3693
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0001 0.0003
Echinococcus granulosus neuropeptide receptor 0.0029 0.0106 0.0106
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0084 0.0591 0.1787
Onchocerca volvulus 0.0029 0.0106 0.0114
Plasmodium falciparum plasmepsin X 0.0023 0.0054 0.0764
Echinococcus multilocularis somatostatin receptor 0.0029 0.0106 0.0106
Brugia malayi Serotonin receptor 0.0029 0.0106 0.0131
Plasmodium falciparum DNase I-like protein, putative 0.0017 0.0001 0.0013
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0071 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Echinococcus multilocularis neutral sphingomyelinase 0.0017 0.0001 0.0001
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0017 0.0001 0.0001
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0001 0.0003
Plasmodium falciparum plasmepsin VIII, putative 0.0023 0.0054 0.0764
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0017 0.0001 0.0013
Plasmodium vivax plasmepsin V, putative 0.0023 0.0054 0.0522
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Trypanosoma cruzi mitochondrial protein 99, putative 0.0017 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.0041 0.0214 0.0265
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0029 0.0106 0.0106
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0017 0.0001 0.0001
Echinococcus multilocularis G protein coupled receptor 139 0.0029 0.0106 0.0106
Brugia malayi aspartic protease BmAsp-1, identical 0.0023 0.0054 0.0067
Echinococcus multilocularis expressed protein 0.0034 0.0157 0.0157
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0045 0.0056
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.0106 0.0131
Schistosoma mansoni smad1 5 8 and 0.0025 0.0071 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0201 0.163 0.163
Trypanosoma brucei calpain-like protein, putative 0.0022 0.0051 0.0153
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Brugia malayi hypothetical protein 0.0029 0.0106 0.0131
Onchocerca volvulus 0.0029 0.0106 0.0114
Loa Loa (eye worm) hypothetical protein 0.0044 0.024 0.0297
Echinococcus granulosus g protein coupled receptor 0.0029 0.0106 0.0106
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0029 0.0106 0.0106
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.006 0.0379 0.0469
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0106 0.0106
Plasmodium falciparum plasmepsin VII 0.0023 0.0054 0.0764
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0054 0.0067
Onchocerca volvulus 0.0029 0.0106 0.0114
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.0106 0.0131
Trypanosoma brucei prolyl endopeptidase 0.0391 0.3308 1
Loa Loa (eye worm) transcription factor SMAD2 0.0365 0.3078 0.3811
Plasmodium vivax aspartyl proteinase, putative 0.0023 0.0054 0.0522
Echinococcus multilocularis deoxyribonuclease 1 2 0.0017 0.0001 0.0001
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0017 0.0001 0.0013
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0001 0.0003
Echinococcus multilocularis Smad4 0.0025 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0052 0.0313 0.0313
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0106 0.0131
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0029 0.0106 0.0106
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0001 0.0003
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0029 0.0106 0.0106
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0001 0.0001
Brugia malayi aspartic protease BmAsp-2, identical 0.0023 0.0054 0.0067
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.0113 0.0848 0.1051
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Echinococcus multilocularis zinc finger protein 0.0027 0.0087 0.0087
Schistosoma mansoni cathepsin D (A01 family) 0.0285 0.2376 0.2376
Plasmodium vivax aspartyl protease, putative 0.0023 0.0054 0.0522
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0054 0.0054
Brugia malayi hypothetical protein 0.0029 0.0106 0.0131
Schistosoma mansoni myosin xvIII 0.0029 0.0106 0.0106
Schistosoma mansoni calpain (C02 family) 0.0022 0.0051 0.0051
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.0106 0.0131
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.0097 0.0708 0.0876
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0097 0.0708 0.0876
Echinococcus granulosus g protein coupled receptor 0.0029 0.0106 0.0106
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0224 0.0224
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0201 0.163 0.163
Brugia malayi hypothetical protein 0.0029 0.0106 0.0131
Plasmodium vivax calpain, putative 0.0022 0.0051 0.0487
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0302 0.2916
Brugia malayi hypothetical protein 0.0023 0.0054 0.0067
Plasmodium falciparum plasmepsin V 0.0023 0.0054 0.0764
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.015 0.0453
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0029 0.0106 0.0106
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0001 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0165 0.131 0.1622
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0041 0.0214 0.0647
Echinococcus multilocularis calpain 0.0022 0.0051 0.0051
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0029 0.0106 0.0106
Echinococcus granulosus fmrfamide receptor 0.0029 0.0106 0.0106
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0042 0.0224 0.0224
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0079 0.0079
Brugia malayi sulfakinin receptor protein 0.0029 0.0106 0.0131
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0075 0.0516 0.0639
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0041 0.0214 0.0647
Brugia malayi hypothetical protein 0.0042 0.0224 0.0278
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0051 0.0153
Schistosoma mansoni opsin-like receptor 0.0029 0.0106 0.0106
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0157 0.0194
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0521 0.5023
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0001 0.0003
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0001 0.0003
Schistosoma mansoni neutral sphingomyelinase 0.0017 0.0001 0.0001
Schistosoma mansoni amine GPCR 0.0029 0.0106 0.0106
Onchocerca volvulus 0.0029 0.0106 0.0114
Echinococcus granulosus serotonin receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0017 0.0001 0.0001
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0023 0.0054 0.0163
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0084 0.0591 0.2006
Schistosoma mansoni hypothetical protein 0.1147 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0201 0.163 0.163
Brugia malayi Ets-domain containing protein 0.0087 0.062 0.0767
Trichomonas vaginalis set domain proteins, putative 0.1058 0.9212 1
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0017 0.0001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0051 0.0153
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0001 0.0001
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0521 0.1574
Schistosoma mansoni amine GPCR 0.0029 0.0106 0.0106
Toxoplasma gondii aspartyl protease ASP1 0.0097 0.0708 0.214
Echinococcus multilocularis hypothetical protein 0.0022 0.0051 0.0051
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0121 0.015
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0041 0.0214 0.0647
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0017 0.0001 0.0001
Brugia malayi GnHR receptor homolog 0.0029 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Schistosoma mansoni hypothetical protein 0.0052 0.0313 0.0313
Onchocerca volvulus 0.0029 0.0106 0.0114
Echinococcus granulosus neuropeptide receptor 0.0029 0.0106 0.0106
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0097 0.0708 0.0708
Trichomonas vaginalis ap endonuclease, putative 0.0084 0.0591 0.0641
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0106 0.0106
Schistosoma mansoni synaptojanin 0.0017 0.0001 0.0001
Trypanosoma brucei prolyl oligopeptidase, putative 0.0155 0.1226 0.3707
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0022 0.0051 0.0153
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0224 0.0224
Onchocerca volvulus 0.0037 0.018 0.0194
Echinococcus granulosus cpg binding protein 0.0034 0.0155 0.0155
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0106 0.0106
Brugia malayi hypothetical protein 0.0029 0.0106 0.0131
Echinococcus granulosus dro:myosuppressin receptor 0.0029 0.0106 0.0106
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0001 0.0003
Brugia malayi Dopamine receptor 0.0029 0.0106 0.0131
Echinococcus granulosus prolyl endopeptidase 0.0391 0.3308 0.3308
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.0106 0.0131
Brugia malayi larval opioid receptor 0.0029 0.0106 0.0131
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0106 0.0106
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0134 0.1036 0.1036
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0029 0.0106 0.0131
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0224 0.0224
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0054 0.0054
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0017 0.0001 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0106 0.0106
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.0106 0.0131
Brugia malayi follicle stimulating hormone receptor 0.0029 0.0106 0.0131
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0155 0.1226 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0157 0.0169
Trypanosoma cruzi prolyl endopeptidase 0.0391 0.3308 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0029 0.0106 0.0106
Echinococcus multilocularis prolyl endopeptidase 0.0391 0.3308 0.3308
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0165 0.131 0.1622
Toxoplasma gondii hypothetical protein 0.0041 0.0214 0.0647
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.062 0.062
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0029 0.0106 0.0106
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0313 0.0313
Trypanosoma cruzi oligopeptidase b 0.0155 0.1226 0.3707
Schistosoma mansoni gabp alpha 0.0087 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Leishmania major endonuclease/exonuclease protein-like protein 0.0017 0.0001 0.0003
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0097 0.0708 0.0768
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0106 0.0106
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.015 0.0453
Echinococcus multilocularis dro:myosuppressin receptor 0.0029 0.0106 0.0106
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.035 0.2946 1
Plasmodium falciparum plasmepsin IV 0.0097 0.0708 1
Echinococcus multilocularis traf and tnf receptor associated protein 0.0017 0.0001 0.0001
Echinococcus granulosus calpain A 0.0022 0.0051 0.0051
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0017 0.0001 0.0001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0189 0.0189
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0106 0.0106
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0017 0.0001 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0134 0.1036 0.1036
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.024 0.024
Schistosoma mansoni cpg binding protein 0.003 0.0121 0.0121
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0041 0.0214 0.0647
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0214 0.0647
Brugia malayi hypothetical protein 0.0029 0.0106 0.0131
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0106 0.0106
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0106 0.0106
Brugia malayi hypothetical protein 0.0023 0.0054 0.0067
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0001 0.0001
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0041 0.0214 0.0214
Schistosoma mansoni Smad4 0.0025 0.0071 0.0071
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0029 0.0106 0.0106
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0017 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0128 0.0987 0.0987
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0097 0.0708 0.214
Brugia malayi hypothetical protein 0.0029 0.0106 0.0131
Onchocerca volvulus 0.0029 0.0106 0.0114
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0041 0.0214 0.3614
Loa Loa (eye worm) hypothetical protein 0.0076 0.0521 0.0645
Toxoplasma gondii prolyl endopeptidase 0.0391 0.3308 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0029 0.0106 0.0106
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0106 0.0106
Onchocerca volvulus 0.0023 0.0054 0.0058
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0012 0.0012
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0029 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0391 0.3308 0.4096
Schistosoma mansoni neuropeptide receptor 0.0029 0.0106 0.0106
Brugia malayi hypothetical protein 0.0049 0.0283 0.0351
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0017 0.0001 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0012 0.0012
Brugia malayi Fli-1 protein 0.0263 0.2183 0.2703
Brugia malayi prolyl oligopeptidase family protein 0.0041 0.0214 0.0265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0022 0.0051 0.0153
Echinococcus multilocularis geminin 0.1147 1 1
Trypanosoma brucei antigen, putative 0.0022 0.0051 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0134 0.1036 0.1036
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0017 0.0001 0.0003
Plasmodium vivax SET domain protein, putative 0.0134 0.1036 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0084 0.0591 0.0591
Echinococcus multilocularis neuropeptide s receptor 0.0029 0.0106 0.0106
Onchocerca volvulus 0.0029 0.0106 0.0114
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0041 0.0214 0.0647
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0106 0.0106
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0041 0.0214 0.0647
Echinococcus multilocularis neuropeptide receptor A26 0.0029 0.0106 0.0106
Onchocerca volvulus 0.0029 0.0106 0.0114
Brugia malayi calpain 7 0.0022 0.0051 0.0063
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0106 0.0106
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0244 0.4125
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.006 0.0379 0.0379
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0201 0.163 0.2018
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0051 0.0051
Plasmodium vivax aspartyl proteinase, putative 0.0097 0.0708 0.683
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0054 0.0054
Echinococcus multilocularis cpg binding protein 0.0034 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0152 0.1197 0.1197
Echinococcus multilocularis synaptojanin 1 0.0017 0.0001 0.0001
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0041 0.0214 0.0232
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Echinococcus granulosus histone acetyltransferase KAT2B 0.016 0.1267 0.1267
Schistosoma mansoni Mername-AA248 (C02 family) 0.0022 0.0051 0.0051
Echinococcus granulosus neutral sphingomyelinase 0.0017 0.0001 0.0001
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0029 0.0106 0.0106
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0106 0.0106
Brugia malayi RE15519p 0.0029 0.0106 0.0131
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.015 0.0453
Loa Loa (eye worm) MH2 domain-containing protein 0.0365 0.3078 0.3811
Plasmodium vivax plasmepsin IV, putative 0.0097 0.0708 0.683
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0041 0.0214 0.0214
Brugia malayi MH2 domain containing protein 0.0025 0.0071 0.0088
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0054 0.0054
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0017 0.0001 0.0001
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0152 0.0152
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0106 0.0106
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.0214 0.3614
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0131
Echinococcus granulosus neuropeptide receptor A26 0.0029 0.0106 0.0106
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0017 0.0001 0.0003
Echinococcus multilocularis calpain 7 (C02 family) 0.0022 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0051 0.0303 0.0375
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0079 0.0079
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0041 0.0214 0.0214
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0155 0.1226 0.3707
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.015 0.0453
Brugia malayi prolyl oligopeptidase family protein 0.0041 0.0214 0.0265
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0017 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0106 0.0106
Plasmodium vivax aspartyl protease, putative 0.0023 0.0054 0.0522
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0214 0.0647
Onchocerca volvulus Neuropeptide F receptor homolog 0.0029 0.0106 0.0114
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0201 0.163 0.163
Loa Loa (eye worm) fli-1 protein 0.0263 0.2183 0.2703
Onchocerca volvulus 0.0029 0.0106 0.0114
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0467 0.0467
Echinococcus granulosus sex peptide receptor 0.0029 0.0106 0.0106
Onchocerca volvulus 0.0029 0.0106 0.0114
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0029 0.0106 0.0106
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0106 0.0106
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0155 0.1226 0.4163
Plasmodium falciparum plasmepsin IX 0.0023 0.0054 0.0764
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0106 0.0106
Schistosoma mansoni zinc finger protein 0.0027 0.0087 0.0087
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0062 0.0403 0.0403
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0017 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0054 0.0067
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.0223

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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