Detailed information for compound 1302605

Basic information

Technical information
  • TDR Targets ID: 1302605
  • Name: N-(3-morpholin-4-ylpropyl)-4-morpholin-4-ylsu lfonylbenzamide
  • MW: 397.489 | Formula: C18H27N3O5S
  • H donors: 1 H acceptors: 3 LogP: -0.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)S(=O)(=O)N1CCOCC1)NCCCN1CCOCC1
  • InChi: 1S/C18H27N3O5S/c22-18(19-6-1-7-20-8-12-25-13-9-20)16-2-4-17(5-3-16)27(23,24)21-10-14-26-15-11-21/h2-5H,1,6-15H2,(H,19,22)
  • InChiKey: OTWFBZLGMQESOB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-morpholinopropyl)-4-morpholinosulfonyl-benzamide
  • N-(3-morpholinopropyl)-4-morpholinosulfonylbenzamide
  • N-(3-morpholin-4-ylpropyl)-4-morpholin-4-ylsulfonyl-benzamide
  • BIM-0026567.P001
  • 4-(Morpholine-4-sulfonyl)-N-(3-morpholin-4-yl-propyl)-benzamide
  • BAS 00917578
  • CBMicro_026643
  • MLS000107510
  • SMR000111876

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0035 0.0091 0.3044
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0082 0.0174
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0592 0.8211
Schistosoma mansoni biogenic amine receptor 0.0032 0.0082 0.0179
Brugia malayi wnt family protein 0.0013 0.0021 0.0015
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0183 0.0397
Brugia malayi Melatonin receptor type 1A 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi larval opioid receptor 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0194 0.0592 0.1296
Brugia malayi Plekhf2 protein 0.0031 0.0077 0.007
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.0942
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Onchocerca volvulus 0.0031 0.0077 0.0929
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Trichomonas vaginalis centaurin beta, putative 0.0031 0.0077 0.1064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0011 0.0021
Brugia malayi hypothetical protein 0.0031 0.0077 0.007
Onchocerca volvulus outspread protein homolog 0.0031 0.0077 0.0929
Brugia malayi Dopamine receptor protein 1 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0075 0.0163
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis beta adrenergic receptor kinase 0.1437 0.4524 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0082 0.0174
Plasmodium vivax SET domain protein, putative 0.003 0.0075 0.5832
Echinococcus granulosus calcium dependent secretion activator 1 0.0031 0.0077 0.0162
Onchocerca volvulus 0.0028 0.0069 0.0824
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.0082 0.0174
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0183 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus multilocularis zinc finger transcription factor gli2 0.0301 0.0931 0.2052
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0592 0.8211
Onchocerca volvulus 0.0032 0.0082 0.1005
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0032 0.0082 0.0174
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0082 0.0174
Onchocerca volvulus 0.0032 0.0082 0.1005
Brugia malayi G-protein coupled receptor 0.0032 0.0082 0.0076
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Echinococcus granulosus serine/threonine protein kinase 0.0035 0.0091 0.0195
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0032 0.0082 0.0174
Schistosoma mansoni thyroid hormone receptor 0.001 0.0011 0.0021
Schistosoma mansoni wnt related 0.0013 0.0021 0.0045
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0005 0.0004
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0035 0.0091 0.3044
Loa Loa (eye worm) hypothetical protein 0.0194 0.0592 0.1296
Brugia malayi Egg laying defective protein 4 0.001 0.0012 0.0006
Echinococcus multilocularis beta 1 syntrophin 0.0031 0.0077 0.0162
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0031 0.0077 0.0162
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0007 0.0012
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0091 0.0739
Echinococcus multilocularis allatostatin A receptor 0.0032 0.0082 0.0174
Echinococcus granulosus neuropeptide receptor A26 0.0032 0.0082 0.0174
Onchocerca volvulus 0.003 0.0075 0.0902
Echinococcus multilocularis wingless type MMTV integration site family 0.0013 0.0021 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0154 0.0334
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0075 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0082 0.0174
Entamoeba histolytica p21-activated kinase 0.0035 0.0091 0.0739
Schistosoma mansoni amine GPCR 0.0032 0.0082 0.0179
Schistosoma mansoni biogenic amine receptor 0.0032 0.0082 0.0179
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.0082 0.0179
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0031 0.0077 0.8138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi Pre-SET motif family protein 0.003 0.0075 0.0068
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0035 0.0091 0.4808
Schistosoma mansoni serine/threonine protein kinase 0.0651 0.2037 0.4502
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.0082 0.0174
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0154 0.0148
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0075 0.0163
Brugia malayi PXA domain containing protein 0.0194 0.0592 0.0586
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.0028
Schistosoma mansoni cpg binding protein 0.003 0.0074 0.0162
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0194 0.0592 0.1306
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus multilocularis regulator of G protein signaling 7 0.0194 0.0592 0.1302
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Loa Loa (eye worm) histone methyltransferase 0.001 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Brugia malayi Dopamine receptor protein 2 0.0032 0.0082 0.0076
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0031 0.0077 0.007
Echinococcus granulosus oxysterol binding protein 9 0.0031 0.0077 0.0162
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0007 0.0007
Brugia malayi wnt family protein 0.0013 0.0021 0.0015
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.0082 0.0179
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0032 0.0082 0.0167
Echinococcus multilocularis WNT 0.0013 0.0021 0.004
Echinococcus multilocularis regulator of G protein signaling 7 0.0194 0.0592 0.1302
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0012 0.0025
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0035 0.0091 0.3044
Brugia malayi wnt family protein 0.0013 0.0021 0.0015
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.0082 0.0179
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0031 0.0077 0.0929
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0592 0.8211
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0031 0.0077 0.0162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus granulosus 7TM GPCR rhodopsin 0.0032 0.0082 0.0174
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0052 0.0107
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0052 0.4948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0009
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0457 0.1425 0.314
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0128 0.0281
Loa Loa (eye worm) zinc finger protein 0.0301 0.0931 0.2047
Echinococcus granulosus dynamin 1 0.0031 0.0077 0.0162
Schistosoma mansoni amine GPCR 0.0032 0.0082 0.0179
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0035 0.0091 0.3044
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.0942
Schistosoma mansoni amine GPCR 0.0032 0.0082 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0009
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.0077 0.0467
Echinococcus granulosus pdz domain containing protein 0.0031 0.0077 0.0162
Echinococcus multilocularis DCC interacting protein 13 beta 0.0031 0.0077 0.0162
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Schistosoma mansoni serine/threonine protein kinase 0.1437 0.4524 1
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Brugia malayi Regulator of G protein signaling domain containing protein 0.0194 0.0592 0.0586
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0031 0.0077 0.007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0154 0.0339
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Echinococcus granulosus dnaJ subfamily B 0.0404 0.1256 0.2772
Echinococcus granulosus neuropeptide receptor 0.0032 0.0082 0.0174
Brugia malayi G protein-coupled receptor 0.0032 0.0082 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Entamoeba histolytica PH domain containing protein 0.0031 0.0077 0.0467
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0154 0.0334
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0091 0.0739
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0031 0.0077 0.6314
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0194 0.0592 0.1296
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0032 0.0082 0.0167
Onchocerca volvulus 0.0031 0.0077 0.0929
Onchocerca volvulus 0.0032 0.0082 0.1005
Echinococcus granulosus neuropeptide s receptor 0.0032 0.0082 0.0174
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0082 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0194 0.0592 0.1302
Schistosoma mansoni hypothetical protein 0.0032 0.0082 0.0179
Echinococcus granulosus muscleblind protein 0.0299 0.0924 0.2036
Schistosoma mansoni wnt related 0.0013 0.0021 0.0045
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0031 0.0077 0.0467
Brugia malayi Regulator of G protein signaling domain containing protein 0.0194 0.0592 0.0586
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0016
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0007 0.0007
Echinococcus granulosus neuropeptide receptor 0.0032 0.0082 0.0174
Schistosoma mansoni regulator of G protein signaling 0.0194 0.0592 0.1306
Schistosoma mansoni wnt related 0.0013 0.0021 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0011 0.0016
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0031 0.0077 0.0162
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.0082 0.0174
Echinococcus granulosus sex peptide receptor 0.0032 0.0082 0.0174
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Schistosoma mansoni hypothetical protein 0.0032 0.0082 0.0179
Brugia malayi probable spectrin beta chain 0.0031 0.0077 0.007
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0007 0.0007
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0116 0.0249
Loa Loa (eye worm) hypothetical protein 0.0299 0.0924 0.2031
Onchocerca volvulus 0.0234 0.0721 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0007 0.0007
Loa Loa (eye worm) TYRA-2 protein 0.0032 0.0082 0.0167
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0082 0.0174
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0012 0.0025
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0031 0.0077 0.1064
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0032 0.0082 0.0076
Brugia malayi steroid hormone receptor 0.001 0.0011 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0011 0.0004
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0091 0.0739
Schistosoma mansoni wnt related 0.0013 0.0021 0.0045
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0107 0.1481
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.0004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0016
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0011 0.0016
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0035 0.0091 0.4641
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0082 0.0167
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0011 0.0016
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0031 0.0077 0.1064
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0031 0.0077 0.0162
Loa Loa (eye worm) hypothetical protein 0.0037 0.0098 0.0202
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0031 0.0077 0.0467
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0457 0.1425 0.3145
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0052 0.0099
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0082 0.0179
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0086 0.0182
Echinococcus multilocularis expressed protein 0.0194 0.0592 0.1302
Brugia malayi regulator of G-protein signaling egl-10 0.0194 0.0592 0.0586
Echinococcus multilocularis wnt family member wnt11 2 0.0013 0.0021 0.004
Toxoplasma gondii hypothetical protein 0.0031 0.0077 0.4579
Schistosoma mansoni dynamin 0.0031 0.0077 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus granulosus Pleckstrin y 0.0031 0.0077 0.0162
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus granulosus Pleckstrin y 0.0031 0.0077 0.0162
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0035 0.0091 0.3044
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0031 0.0077 0.1922
Echinococcus multilocularis Pleckstrin y 0.0031 0.0077 0.0162
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.0082 0.0174
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0315 0.0309
Schistosoma mansoni regulator of G protein signaling 0.0194 0.0592 0.1306
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis Oxysterol binding protein 11 0.0031 0.0077 0.0162
Schistosoma mansoni histamine h1 receptor 0.0032 0.0082 0.0179
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0007 0.0012
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Echinococcus granulosus g protein coupled receptor 0.0032 0.0082 0.0174
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0183 0.2429
Echinococcus granulosus GPCR family 2 0.0034 0.0086 0.0182
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0075 0.4442
Echinococcus multilocularis Rho GTPase activating protein 24 0.0031 0.0077 0.0162
Brugia malayi neuropeptide F receptor 0.0032 0.0082 0.0076
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0167
Brugia malayi Zinc finger, C2H2 type family protein 0.0301 0.0931 0.0925
Schistosoma mansoni ap endonuclease 0.0023 0.0052 0.0111
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0194 0.0592 0.1302
Leishmania major serine/threonine-protein kinase a, putative 0.0035 0.0091 0.4641
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0035 0.0091 0.4808
Trichomonas vaginalis centaurin/arf, putative 0.0031 0.0077 0.1064
Loa Loa (eye worm) uncoordinated protein 104 0.0031 0.0077 0.0155
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0031 0.0077 0.0167
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Brugia malayi G protein-coupled receptor F59B2.13 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0072 0.0209 0.0448
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0102 0.0219
Echinococcus granulosus hypothetical protein 0.0032 0.0082 0.0174
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0011 0.0009
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0031 0.0077 0.1922
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0011 0.0021
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Schistosoma mansoni regulator of G protein signaling 0.0194 0.0592 0.1306
Onchocerca volvulus Putative zinc finger protein 0.0031 0.0077 0.0929
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.2103 0.4644
Schistosoma mansoni zinc finger protein 0.0031 0.0077 0.0167
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0082 0.0167
Onchocerca volvulus 0.0031 0.0077 0.0929
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0011 0.0009
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0007 0.0092
Loa Loa (eye worm) CWN-2 protein 0.0013 0.0021 0.0033
Schistosoma mansoni oxysterol-binding protein 1 0.0031 0.0077 0.0167
Trypanosoma cruzi Protein kinase B 0.0035 0.0091 0.3044
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0011 0.0021
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0457 0.1425 0.314
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0052 0.2297
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus granulosus regulator of G protein signaling 3 0.0194 0.0592 0.1302
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0107 0.1481
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0011 0.0021
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0631 0.1383
Echinococcus granulosus alpha 1A adrenergic receptor 0.0032 0.0082 0.0174
Onchocerca volvulus Protein melted homolog 0.0031 0.0077 0.0929
Echinococcus granulosus tachykinin peptides receptor 99D 0.0032 0.0082 0.0174
Echinococcus granulosus microtubule associated protein 2 0.0671 0.2103 0.4644
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0082 0.0174
Echinococcus multilocularis axis inhibition protein axin 0.0194 0.0592 0.1302
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.0082 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0592 0.8211
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus granulosus expressed protein 0.0194 0.0592 0.1302
Loa Loa (eye worm) hypothetical protein 0.0106 0.0315 0.0683
Loa Loa (eye worm) AGC/AKT protein kinase 0.0035 0.0091 0.0188
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0183 0.0402
Loa Loa (eye worm) oxysterol binding protein 0.0031 0.0077 0.0155
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0194 0.0592 0.8211
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0075 0.0158
Brugia malayi Wnt-4 protein precursor 0.0013 0.0021 0.0015
Trichomonas vaginalis protein transport protein sec7, putative 0.0031 0.0077 0.1064
Loa Loa (eye worm) RGS-3 protein 0.0194 0.0592 0.1296
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0651 0.2037 0.4495
Trypanosoma cruzi NIMA-related kinase, putative 0.0035 0.0091 0.3044
Echinococcus multilocularis axis inhibition protein axin 0.0194 0.0592 0.1302
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0086 0.0182
Echinococcus granulosus regulator of G protein signaling 7 0.0194 0.0592 0.1302
Trichomonas vaginalis centaurin/arf, putative 0.0031 0.0077 0.1064
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0082 0.0174
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0052 0.0107
Entamoeba histolytica hypothetical protein 0.0031 0.0077 0.0467
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi Syntrophin-1 0.0031 0.0077 0.007
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Schistosoma mansoni adenoreceptor 0.0032 0.0082 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.0004
Brugia malayi Dynamin 0.0031 0.0077 0.007
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0031 0.0077 0.8138
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.0942
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0069 0.0146
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0031 0.0077 0.0162
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0011 0.0021
Entamoeba histolytica hypothetical protein 0.0194 0.0592 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0082 0.0179
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0011 0.0021
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0082 0.0174
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0005 0.0004
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0035 0.0091 0.3044
Schistosoma mansoni syntrophin 0.0031 0.0077 0.0167
Echinococcus multilocularis regulator of G protein signaling 3 0.0194 0.0592 0.1302
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0031 0.0077 0.0929
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus granulosus regulator of G protein signaling 3 0.0194 0.0592 0.1302
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.0082 0.0179
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0007 0.0007
Brugia malayi RE15519p 0.0032 0.0082 0.0076
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Schistosoma mansoni nuclear hormone receptor 0.001 0.0011 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0082 0.0179
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0033
Echinococcus multilocularis cGMP dependent protein kinase 1 0.001 0.0012 0.002
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus granulosus Pleckstrin y 0.0031 0.0077 0.0162
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.0004
Echinococcus granulosus Protein Wnt-04 0.0013 0.0021 0.004
Schistosoma mansoni z-protein (S1r protein) 0.0194 0.0592 0.1306
Echinococcus multilocularis calcium dependent secretion activator 1 0.0031 0.0077 0.0162
Echinococcus multilocularis Regulator of G protein signaling 20 0.0194 0.0592 0.1302
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0031 0.0077 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0009
Echinococcus granulosus myotubularin protein 13 0.0031 0.0077 0.0162
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0031 0.0077 0.0155
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) Wnt2 protein 0.0013 0.0021 0.0033
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0082 0.0174
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0019 0.0035
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.0007 0.0007
Onchocerca volvulus 0.0031 0.0077 0.0929
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0075 0.0158
Schistosoma mansoni hypothetical protein 0.0039 0.0102 0.0224
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0082 0.0174
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0031 0.0077 0.0162
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis rac serine:threonine kinase 0.0035 0.0091 0.0195
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0052 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Schistosoma mansoni hypothetical protein 0.0032 0.0082 0.0179
Schistosoma mansoni neuropeptide receptor 0.0032 0.0082 0.0179
Trypanosoma cruzi PH domain containing protein, putative 0.0031 0.0077 0.1922
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0019 0.004
Onchocerca volvulus 0.0032 0.0082 0.1005
Echinococcus granulosus orexin receptor type 2 0.0032 0.0082 0.0174
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.0082 0.0174
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0031 0.0077 0.1064
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Brugia malayi hypothetical protein 0.0194 0.0592 0.0586
Trypanosoma cruzi PH domain containing protein, putative 0.0031 0.0077 0.1922
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0167
Echinococcus granulosus protein Wnt 2 0.0013 0.0021 0.004
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0011 0.0004
Entamoeba histolytica hypothetical protein 0.0194 0.0592 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0007 0.0012
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0082 0.0174
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0592 0.8211
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0154 0.0334
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0011 0.0004
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0035 0.0091 0.4808
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Loa Loa (eye worm) cytohesin 3 0.0031 0.0077 0.0155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0032 0.0082 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Echinococcus multilocularis muscleblind protein 0.0299 0.0924 0.2036
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Onchocerca volvulus 0.0032 0.0082 0.1005
Schistosoma mansoni hypothetical protein 0.0072 0.0209 0.0459
Loa Loa (eye worm) melatonin receptor type 1A 0.0032 0.0082 0.0167
Schistosoma mansoni hypothetical protein 0.0034 0.0086 0.0187
Schistosoma mansoni axis inhibition protein axin 0.0194 0.0592 0.1306
Echinococcus multilocularis pleckstrin y domain containing family A 0.0031 0.0077 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0154 0.0339
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0011 0.0021
Schistosoma mansoni opsin-like receptor 0.0032 0.0082 0.0179
Brugia malayi Protein kinase domain containing protein 0.0035 0.0091 0.0085
Onchocerca volvulus 0.0032 0.0082 0.1005
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0052 0.2536
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0035 0.0091 0.5627
Entamoeba histolytica ARF GTPase activating protein, putative 0.0031 0.0077 0.0467
Brugia malayi regulator of G-protein signaling rgs-7 0.0194 0.0592 0.0586
Toxoplasma gondii AtPH1 family protein 0.0031 0.0077 0.4579
Toxoplasma gondii hypothetical protein 0.0031 0.0077 0.4579
Schistosoma mansoni regulator of G protein signaling 0.0194 0.0592 0.1306
Loa Loa (eye worm) PH domain-containing protein 0.0031 0.0077 0.0155
Echinococcus granulosus axis inhibition protein axin 0.0194 0.0592 0.1302
Trypanosoma cruzi PH domain containing protein, putative 0.0031 0.0077 0.1922
Echinococcus multilocularis cpg binding protein 0.003 0.0074 0.0157
Echinococcus multilocularis regulator of G protein signaling 3 0.0194 0.0592 0.1302
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0035 0.0091 0.3044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0173 0.0381
Toxoplasma gondii phosphatidylinositol transfer protein 0.0031 0.0077 0.4579
Loa Loa (eye worm) AGC/PKG protein kinase 0.001 0.0012 0.0013
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Echinococcus granulosus pleckstrin y domain containing family A 0.0031 0.0077 0.0162
Echinococcus granulosus oxysterol binding protein 1 0.0031 0.0077 0.0162
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0033
Echinococcus multilocularis protein Wnt 1 0.0013 0.0021 0.004
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.0082 0.0174
Echinococcus granulosus allatostatin A receptor 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Loa Loa (eye worm) hypothetical protein 0.0194 0.0592 0.1296
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0052 0.0715
Schistosoma mansoni biogenic amine receptor 0.0032 0.0082 0.0179
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0075 0.0163
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0082 0.0167
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi follicle stimulating hormone receptor 0.0032 0.0082 0.0076
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.0082 0.0174
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0031 0.0077 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Brugia malayi wnt family protein 0.0013 0.0021 0.0015
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0091 0.0739
Onchocerca volvulus 0.0032 0.0082 0.1005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Schistosoma mansoni opsin-like receptor 0.0032 0.0082 0.0179
Plasmodium falciparum oxysterol-binding protein, putative 0.0031 0.0077 0.8138
Echinococcus multilocularis pdz domain containing protein 0.0031 0.0077 0.0162
Schistosoma mansoni zinc finger protein 0.0031 0.0077 0.0167
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0031 0.0077 0.0162
Echinococcus multilocularis protein Wnt 2 0.0013 0.0021 0.004
Brugia malayi Pre-SET motif family protein 0.0206 0.0631 0.0625
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.0007 0.0007
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Onchocerca volvulus 0.0031 0.0077 0.0929
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0007 0.0007
Schistosoma mansoni neuropeptide receptor 0.0032 0.0082 0.0179
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.0082 0.0174
Schistosoma mansoni vav2 0.0031 0.0077 0.0167
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0035 0.0091 0.3044
Schistosoma mansoni wnt-5 0.0013 0.0021 0.0045
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0082 0.0179
Brugia malayi ecdysteroid receptor 0.001 0.0011 0.0004
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.0082 0.0174
Echinococcus granulosus cGMP dependent protein kinase 1 0.001 0.0012 0.002
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.0082 0.0174
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0031 0.0077 0.0162
Echinococcus multilocularis regulator of G protein signaling 0.0194 0.0592 0.1302
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0651 0.2037 0.2032
Schistosoma mansoni hypothetical protein 0.0032 0.0082 0.0179
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0007 0.0092
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0116 0.0242
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi putative neuropeptide receptor 0.0032 0.0082 0.0076
Brugia malayi TBC domain containing protein 0.0031 0.0077 0.007
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0194 0.0592 0.1296
Leishmania major hypothetical protein, conserved 0.0031 0.0077 0.3777
Brugia malayi Cytohesin 3 0.0031 0.0077 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0153 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0032 0.0082 0.0076
Echinococcus granulosus zinc finger transcription factor gli2 0.0301 0.0931 0.2052
Echinococcus granulosus cGMP dependent protein kinase 1 0.001 0.0012 0.002
Echinococcus multilocularis serotonin receptor 0.0032 0.0082 0.0174
Echinococcus granulosus Protein Wnt-111 0.0013 0.0021 0.004
Toxoplasma gondii protein kinase domain-containing protein 0.0035 0.0091 0.5627
Echinococcus granulosus cytohesin 1 0.0031 0.0077 0.0162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0097 0.0208
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus multilocularis Ras associated and pleckstrin y 0.0031 0.0077 0.0162
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0032 0.0082 0.1005
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0031 0.0077 0.0162
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0082 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0004
Onchocerca volvulus 0.0032 0.0082 0.1005
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0082 0.0174
Leishmania major hypothetical protein, conserved 0.0031 0.0077 0.3777
Entamoeba histolytica hypothetical protein 0.0031 0.0077 0.0467
Echinococcus granulosus cGMP dependent protein kinase 0.001 0.0012 0.002
Echinococcus granulosus axis inhibition protein axin 0.0194 0.0592 0.1302
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Leishmania major folate/biopterin transporter, putative 0.0035 0.0091 0.4641
Brugia malayi GnHR receptor homolog 0.0032 0.0082 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus granulosus FTZ F1 alpha 0.001 0.0011 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Brugia malayi G-protein coupled receptor 0.0032 0.0082 0.0076
Echinococcus granulosus peptide allatostatin:somatostatin 0.0032 0.0082 0.0174
Echinococcus granulosus cpg binding protein 0.003 0.0074 0.0157
Trypanosoma cruzi NIMA-related kinase, putative 0.0035 0.0091 0.3044
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Brugia malayi ORL1-like opioid receptor 0.0032 0.0082 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Echinococcus granulosus beta 1 syntrophin 0.0031 0.0077 0.0162
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0082 0.0174
Brugia malayi AKH receptor 0.0032 0.0082 0.0076
Schistosoma mansoni thyroid hormone receptor 0.001 0.0011 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Brugia malayi hypothetical protein 0.0039 0.0102 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0031 0.0077 0.0162
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.0082 0.0179
Entamoeba histolytica hypothetical protein 0.0039 0.0102 0.0942
Echinococcus multilocularis GPCR, family 2 0.0034 0.0086 0.0182
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Loa Loa (eye worm) PXA domain-containing protein 0.0194 0.0592 0.1296
Schistosoma mansoni axis inhibition protein axin 0.0194 0.0592 0.1306
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Schistosoma mansoni dynamin 0.0031 0.0077 0.0167
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0082 0.0174
Toxoplasma gondii exonuclease III APE 0.0023 0.0052 0.2784
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0052 0.0715
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.0082 0.0179
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0035 0.0091 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0154 0.0334
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0077 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Toxoplasma gondii Oxysterol-binding protein 0.0031 0.0077 0.4579
Brugia malayi Oxysterol-binding protein 0.0031 0.0077 0.007
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0183 0.0397
Echinococcus granulosus somatostatin receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0082 0.0179
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0031 0.0077 0.0155
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0031 0.0077 0.0167
Schistosoma mansoni cpg binding protein 0.0028 0.0069 0.0151
Onchocerca volvulus 0.0032 0.0082 0.1005
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0019 0.004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus granulosus g-protein coupled receptor 0.0032 0.0082 0.0174
Brugia malayi sulfakinin receptor protein 0.0032 0.0082 0.0076
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0077 0.007
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0031 0.0077 0.6314
Loa Loa (eye worm) hypothetical protein 0.0034 0.0086 0.0175
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0082 0.0174
Schistosoma mansoni serine/threonine-protein kinase 0.0035 0.0091 0.02
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0091 0.0739
Onchocerca volvulus 0.0031 0.0077 0.0929
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0011 0.0016
Echinococcus granulosus beta-adrenergic receptor kinase 0.1437 0.4524 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0011 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0016
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.0082 0.0179
Echinococcus granulosus Rho GTPase activating protein 24 0.0031 0.0077 0.0162
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0052 0.5
Echinococcus granulosus Protein Wnt-11b 0.0013 0.0021 0.004
Brugia malayi Muscleblind-like protein 0.0299 0.0924 0.0918
Loa Loa (eye worm) hypothetical protein 0.0194 0.0592 0.1296
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0315 0.0309
Schistosoma mansoni oxysterol-binding protein 1 0.0031 0.0077 0.0167
Brugia malayi Serotonin receptor 0.0032 0.0082 0.0076
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0183 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0019 0.0035
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0019 0.0035
Echinococcus granulosus oxysterol binding protein 3 0.0031 0.0077 0.0162
Echinococcus multilocularis Pleckstrin y 0.0031 0.0077 0.0162
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0077 0.6314
Brugia malayi neuropeptide F receptor 0.0032 0.0082 0.0076
Loa Loa (eye worm) rho-GTPase-activating 0.0031 0.0077 0.0155
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0457 0.1425 0.3145
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0031 0.0077 0.007
Leishmania major protein kinase, putative 0.0035 0.0091 0.4641
Brugia malayi Wnt-2 protein precursor 0.0013 0.0021 0.0015
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0035 0.0091 0.1269
Onchocerca volvulus 0.0031 0.0077 0.0929
Trichomonas vaginalis centaurin gamma, putative 0.0031 0.0077 0.1064
Entamoeba histolytica hypothetical protein 0.0035 0.0091 0.0739
Schistosoma mansoni ap endonuclease 0.0023 0.0052 0.0111
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.0082 0.0174
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0167
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Schistosoma mansoni centaurin alpha 0.0031 0.0077 0.0167
Echinococcus granulosus serotonin receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0086 0.0182
Entamoeba histolytica hypothetical protein 0.0031 0.0077 0.0467
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0075 0.0163
Echinococcus granulosus DCC interacting protein 13 beta 0.0031 0.0077 0.0162
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0011 0.0016
Echinococcus multilocularis GRB2 associated binding protein 3 0.0031 0.0077 0.0162
Trichomonas vaginalis alpha chimerin, putative 0.0031 0.0077 0.1064
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0012 0.0025
Onchocerca volvulus 0.0032 0.0082 0.1005
Brugia malayi Dynamin 0.0031 0.0077 0.007
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis oxysterol binding protein 1 0.0031 0.0077 0.0162
Echinococcus multilocularis myotubularin protein 13 0.0031 0.0077 0.0162
Onchocerca volvulus 0.0032 0.0082 0.1005
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.0082 0.0179
Schistosoma mansoni neuropeptide receptor 0.0032 0.0082 0.0179
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0031 0.0077 0.0467
Brugia malayi nuclear hormone receptor 0.001 0.0011 0.0004
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Echinococcus multilocularis orexin receptor type 2 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0033
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis actin binding protein anillin 0.0031 0.0077 0.0162
Onchocerca volvulus 0.0032 0.0082 0.1005
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0082 0.0174
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0052 0.0045
Schistosoma mansoni goodpasture antigen-binding protein 0.0031 0.0077 0.0167
Echinococcus granulosus g protein coupled receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0031 0.0077 0.0162
Onchocerca volvulus 0.0032 0.0082 0.1005
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0315 0.0683
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0082 0.0179
Brugia malayi nuclear receptor NHR-88 0.001 0.0011 0.0004
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0082 0.0179
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0052 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0032 0.0082 0.0076
Schistosoma mansoni opsin-like receptor 0.0032 0.0082 0.0179
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0082 0.0174
Schistosoma mansoni rho gtpase activating protein 0.0031 0.0077 0.0167
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0086 0.0079
Onchocerca volvulus Neuropeptide F receptor homolog 0.0032 0.0082 0.1005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Schistosoma mansoni regulator of G protein signaling 0.0194 0.0592 0.1306
Echinococcus multilocularis WNT 0.0013 0.0021 0.004
Plasmodium falciparum PH domain-containing protein, putative 0.0031 0.0077 0.8138
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus granulosus Oxysterol binding protein 11 0.0031 0.0077 0.0162
Brugia malayi MAX-1A 0.0031 0.0077 0.007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0011 0.0004
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0194 0.0592 0.1306
Loa Loa (eye worm) syntrophin-1 0.0031 0.0077 0.0155
Echinococcus granulosus 7tm_1 domain containing protein 0.0032 0.0082 0.0174
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0032 0.0082 0.0167
Loa Loa (eye worm) hypothetical protein 0.0299 0.0924 0.2031
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0031 0.0077 0.8138
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0031 0.0077 0.8138
Echinococcus multilocularis serotonin receptor 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.003 0.0075 0.0151
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0031 0.0077 0.1064
Schistosoma mansoni amine GPCR 0.0032 0.0082 0.0179
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Trypanosoma cruzi PH domain containing protein, putative 0.0031 0.0077 0.1922
Echinococcus multilocularis oxysterol binding protein 9 0.0031 0.0077 0.0162
Echinococcus granulosus G protein coupled receptor kinase 1 0.1243 0.3912 0.8645
Onchocerca volvulus 0.0032 0.0082 0.1005
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Brugia malayi Dopamine receptor 0.0032 0.0082 0.0076
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0031 0.0077 0.1064
Schistosoma mansoni myotubularin-related protein 0.0031 0.0077 0.0167
Entamoeba histolytica hypothetical protein 0.0194 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis cytohesin 1 0.0031 0.0077 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0004
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0082 0.0174
Trichomonas vaginalis protein transport protein sec7, putative 0.0031 0.0077 0.1064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0154 0.0339
Echinococcus granulosus neuropeptide FF receptor 2 0.0032 0.0082 0.0174
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0011 0.0021
Echinococcus granulosus regulator of G protein signaling 7 0.0194 0.0592 0.1302
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0032 0.0082 0.0167
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0035 0.0091 0.1269
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0019 0.0013
Entamoeba histolytica PH domain containing protein 0.0031 0.0077 0.0467
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0102 0.0219
Echinococcus granulosus protein Wnt 1 0.0013 0.0021 0.004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0086 0.0175
Echinococcus multilocularis G protein coupled receptor kinase 1 0.1243 0.3912 0.8645
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus granulosus GRB2 associated binding protein 3 0.0031 0.0077 0.0162
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0007 0.0012
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0031 0.0077 0.1064
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0069 0.0139
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.2103 0.4647
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0035 0.0091 0.4641
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0007 0.0007
Schistosoma mansoni goodpasture antigen-binding protein 0.0031 0.0077 0.0167
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.0082 0.0174
Trichomonas vaginalis kinesin light chain, putative 0.0031 0.0077 0.1064
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0031 0.0077 0.0162
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0086 0.0182
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0035 0.0091 0.4808
Echinococcus multilocularis sex peptide receptor 0.0032 0.0082 0.0174
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.0082 0.0179
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0031 0.0077 0.0467
Trichomonas vaginalis centaurin alpha, putative 0.0031 0.0077 0.1064
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0154 0.0327
Echinococcus granulosus G protein coupled receptor 139 0.0032 0.0082 0.0174
Brugia malayi hypothetical protein 0.0032 0.0082 0.0076
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0031 0.0077 0.0155
Schistosoma mansoni myosin xvIII 0.0032 0.0082 0.0179
Brugia malayi hypothetical protein 0.0194 0.0592 0.0586
Schistosoma mansoni cpg binding protein 0.003 0.0074 0.0162
Schistosoma mansoni growth factor receptor-bound protein 0.0031 0.0077 0.0167
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trypanosoma brucei PH domain containing protein, putative 0.0031 0.0077 0.397
Schistosoma mansoni hypothetical protein 0.0034 0.0086 0.0187
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0016
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0082 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0011 0.0004
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0052 0.5
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi CXXC zinc finger family protein 0.0028 0.0069 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0004
Plasmodium falciparum calcium-dependent protein kinase 7 0.0035 0.0091 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0005 0.0004
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0005 0.0009
Schistosoma mansoni hypothetical protein 0.0404 0.1256 0.2775
Brugia malayi Uncoordinated protein 104 0.0031 0.0077 0.007
Brugia malayi putative neuropeptide receptor NPR1 0.0032 0.0082 0.0076
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0007 0.0012
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.0082 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0011 0.0004
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0086 0.0079
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0183 0.0176
Trypanosoma brucei rac serine-threonine kinase, putative 0.0035 0.0091 0.4808
Schistosoma mansoni coup transcription factor 0.001 0.0011 0.0021
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0183 1
Echinococcus multilocularis cGMP dependent protein kinase 1 0.001 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Brugia malayi Cadps2 protein 0.0031 0.0077 0.007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0082 0.0179
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0035 0.0091 0.3044
Echinococcus multilocularis oxysterol binding protein 3 0.0031 0.0077 0.0162
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0011 0.0004
Entamoeba histolytica PH domain containing protein 0.0031 0.0077 0.0467
Entamoeba histolytica hypothetical protein 0.0031 0.0077 0.0467
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0031 0.0077 0.0167
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0116 0.0249
Schistosoma mansoni serine/threonine-protein kinase 0.0035 0.0091 0.02
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.1256 0.2772
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0011 0.0017
Loa Loa (eye worm) hypothetical protein 0.0013 0.0021 0.0033
Schistosoma mansoni hypothetical protein 0.0034 0.0086 0.0187
Echinococcus multilocularis muscleblind protein 1 0.0299 0.0924 0.2036
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0011 0.0021
Echinococcus granulosus fmrfamide receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.0082 0.0174
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0031 0.0077 0.1922
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Brugia malayi Oxysterol binding protein 0.0031 0.0077 0.007
Schistosoma mansoni amine GPCR 0.0032 0.0082 0.0179
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0031 0.0077 0.0162
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0016
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Echinococcus multilocularis dynamin 1 0.0031 0.0077 0.0162
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0011 0.0017
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0005 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.1437 0.4524 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Echinococcus granulosus g protein coupled receptor 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.0031 0.0077 0.0155
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.1437 0.4524 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0082 0.0174
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0097 0.0208
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Entamoeba histolytica hypothetical protein 0.0031 0.0077 0.0467
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0082 0.0174
Schistosoma mansoni neuropeptide receptor 0.0032 0.0082 0.0179
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Leishmania major protein kinase, putative 0.0035 0.0091 0.4641
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0031 0.0077 0.0467
Trichomonas vaginalis AGC family protein kinase 0.0035 0.0091 0.1269
Schistosoma mansoni hypothetical protein 0.0034 0.0086 0.0187
Echinococcus multilocularis Pleckstrin y 0.0031 0.0077 0.0162
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0032 0.0082 0.0167
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0007 0.0012
Brugia malayi A-kinase anchor protein 10, precursor 0.0194 0.0592 0.0586
Trypanosoma brucei protein kinase, putative 0.0035 0.0091 0.4808
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0082 0.0174
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0721 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0457 0.1425 0.1419
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0031 0.0077 0.0155
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0082 0.0179
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0183 1
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0031 0.0077 0.0167
Echinococcus multilocularis expressed conserved protein 0.001 0.0012 0.002
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Trichomonas vaginalis hypothetical protein 0.0031 0.0077 0.1064
Onchocerca volvulus 0.0032 0.0082 0.1005
Brugia malayi Pleckstrin Homology Domain 0.0031 0.0077 0.007
Entamoeba histolytica protein kinase, putative 0.0035 0.0091 0.0739
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0082 0.0174
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0102 0.0224
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0116 0.0109
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0031 0.0077 0.0467
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0082 0.0167
Loa Loa (eye worm) Plekhf2 protein 0.0031 0.0077 0.0155
Entamoeba histolytica PH domain containing protein kinase, putative 0.0035 0.0091 0.0739
Onchocerca volvulus 0.0032 0.0082 0.1005
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0031 0.0077 0.0162
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0052 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0032 0.0082 0.0076
Onchocerca volvulus 0.0032 0.0082 0.1005
Schistosoma mansoni hypothetical protein 0.0031 0.0077 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0194 0.0592 0.8211
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.0007 0.0007
Echinococcus granulosus dro:myosuppressin receptor 0.0032 0.0082 0.0174
Echinococcus multilocularis somatostatin receptor 0.0032 0.0082 0.0174
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0128 0.0281
Loa Loa (eye worm) wnt-4 protein 0.0013 0.0021 0.0033
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0019 0.0035
Trypanosoma cruzi hypothetical protein 0.0031 0.0077 0.1922
Echinococcus granulosus Regulator of G protein signaling 20 0.0194 0.0592 0.1302
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0183 0.039
Brugia malayi PH domain containing protein 0.0031 0.0077 0.007
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0209 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0077 0.1064
Loa Loa (eye worm) hypothetical protein 0.0194 0.0592 0.1296
Brugia malayi PXA domain containing protein 0.0194 0.0592 0.0586
Plasmodium vivax PH domain containing protein 0.0031 0.0077 0.6314
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0004
Entamoeba histolytica hypothetical protein 0.0035 0.0091 0.0739
Loa Loa (eye worm) hypothetical protein 0.0032 0.0082 0.0167
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0194 0.0592 0.1306
Echinococcus granulosus Protein Wnt-5 0.0013 0.0021 0.004
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0031 0.0077 0.0162

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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