Detailed information for compound 1311944

Basic information

Technical information
  • TDR Targets ID: 1311944
  • Name: N-(2-methylphenyl)-1-oxo-4-phenylisochromene- 3-carboxamide
  • MW: 355.386 | Formula: C23H17NO3
  • H donors: 1 H acceptors: 2 LogP: 4.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1NC(=O)c1oc(=O)c2c(c1c1ccccc1)cccc2
  • InChi: 1S/C23H17NO3/c1-15-9-5-8-14-19(15)24-22(25)21-20(16-10-3-2-4-11-16)17-12-6-7-13-18(17)23(26)27-21/h2-14H,1H3,(H,24,25)
  • InChiKey: CHQLBTMMAZLDHG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-methylphenyl)-1-oxo-4-phenyl-isochromene-3-carboxamide
  • N-(2-methylphenyl)-1-oxo-4-phenyl-3-isochromenecarboxamide
  • 1-keto-N-(2-methylphenyl)-4-phenyl-isochromene-3-carboxamide
  • MLS000583167
  • N-(2-methylphenyl)-1-oxo-4-phenyl-1H-isochromene-3-carboxamide
  • SMR000206353
  • Oprea1_692126

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0079 0.0254
Brugia malayi hypothetical protein 0.033 0.0785 0.3796
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0125 0.0276 0.092
Schistosoma mansoni inositol monophosphatase 0.0109 0.0236 0.0796
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0079 0.0383
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0057 0.1365
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0088 0.0296
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0022 0.0505
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0019 0.0061
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.015 0.0339 0.1144
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0206 0.0998
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0006 0.0026
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0146
Schistosoma mansoni survival motor neuron protein 0.0097 0.0206 0.0696
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0138 0.0307 0.1039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0692 0.1684 0.8145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0028 0.0137
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0006 0.0027
Loa Loa (eye worm) latrophilin receptor protein 2 0.0125 0.0276 0.1333
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0088 0.0285
Echinococcus granulosus nuclear receptor nhr 48 0.0023 0.0023 0.0063
Echinococcus multilocularis zinc finger protein 0.0019 0.0012 0.0007
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0057 0.0053
Loa Loa (eye worm) hypothetical protein 0.008 0.0164 0.0794
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0088 0.0084
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0074 0.0356
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0054 0.1291
Brugia malayi nuclear hormone receptor family member odr-7 0.0023 0.0023 0.0112
Schistosoma mansoni ap endonuclease 0.0037 0.0058 0.0192
Brugia malayi nuclear hormone receptor 0.0023 0.0023 0.0112
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0042 0.0202
Trichomonas vaginalis set domain proteins, putative 0.0963 0.2358 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Toxoplasma gondii thioredoxin reductase 0.0046 0.0079 0.1848
Leishmania major trypanothione reductase 0.0046 0.0079 0.1907
Loa Loa (eye worm) beta-lactamase 0.015 0.0339 0.1637
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0125 0.0276 0.1333
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0042 0.092
Schistosoma mansoni lamin 0.0082 0.0168 0.0566
Loa Loa (eye worm) fibroinase 0.0016 0.0006 0.0027
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0062 0.0208
Brugia malayi Fli-1 protein 0.0226 0.0526 0.2545
Onchocerca volvulus 0.0016 0.0006 0.0015
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0088 0.0428
Loa Loa (eye worm) hypothetical protein 0.0053 0.0097 0.0467
Echinococcus granulosus cathepsin l1 0.0016 0.0006 0.0004
Echinococcus multilocularis Smad4 0.0026 0.0028 0.0024
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0224
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0329 0.0781 0.3779
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0088 0.0428
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0028 0.0137
Brugia malayi orphan nuclear receptor NR2E1 0.0023 0.0023 0.0112
Echinococcus granulosus GPCR family 2 0.0125 0.0276 0.092
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0088 0.0296
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0125 0.0276 0.0271
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0601 0.2033
Onchocerca volvulus Alhambra homolog 0.0031 0.0042 0.0168
Echinococcus multilocularis tar DNA binding protein 0.0256 0.0601 0.0596
Loa Loa (eye worm) hypothetical protein 0.0138 0.0307 0.1487
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0042 0.0138
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0088 0.0296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0395 0.0947 0.4579
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.012 0.2906
Echinococcus multilocularis GPCR, family 2 0.0125 0.0276 0.0271
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0022 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi hypothetical protein 0.0179 0.0409 0.1977
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0054 0.0169
Onchocerca volvulus 0.0099 0.0211 0.0886
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0088 0.0084
Brugia malayi Pre-SET motif family protein 0.0121 0.0267 0.1289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0226 0.0576
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Brugia malayi glutathione reductase 0.0046 0.0079 0.0383
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0042 0.092
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0054 0.1291
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0005 0.0002
Echinococcus granulosus smad 0.0026 0.0028 0.0081
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0057 0.0662
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0106 0.2575
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0054 0.935
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0058 0.0279
Echinococcus granulosus zinc finger protein 0.0019 0.0012 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0088 0.0084
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0022 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0028 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0088 0.0428
Loa Loa (eye worm) hypothetical protein 0.027 0.0636 0.3077
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0058 0.2296
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0057 0.0179
Schistosoma mansoni Smad4 0.0026 0.0028 0.0093
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0088 0.0296
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0381 0.0377
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Brugia malayi Bromodomain containing protein 0.0072 0.0145 0.0701
Schistosoma mansoni nuclear hormone receptor 0.005 0.0088 0.0296
Mycobacterium tuberculosis Probable hydrolase 0.015 0.0339 0.0869
Entamoeba histolytica hypothetical protein 0.033 0.0785 1
Schistosoma mansoni hypothetical protein 0.002 0.0014 0.0045
Trichomonas vaginalis penicillin-binding protein, putative 0.015 0.0339 0.1419
Trypanosoma brucei hypothetical protein, conserved 0.015 0.0339 0.8275
Schistosoma mansoni jumonji domain containing protein 0.008 0.0165 0.0555
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0006 0.0001
Trypanosoma brucei PAB1-binding protein , putative 0.0179 0.0409 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi MH2 domain containing protein 0.0026 0.0028 0.0137
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Schistosoma mansoni transcription factor LCR-F1 0.033 0.0785 0.2658
Brugia malayi latrophilin 2 splice variant baaae 0.027 0.0636 0.3077
Toxoplasma gondii exonuclease III APE 0.0037 0.0058 0.1314
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.0339 0.8275
Onchocerca volvulus 0.0016 0.0006 0.0015
Brugia malayi Latrophilin receptor protein 2 0.0125 0.0276 0.1333
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0088 0.0285
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0023 0.0023 0.0063
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0042 0.0037
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0255 0.0608
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0395 0.0947 0.4579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi jmjC domain containing protein 0.0101 0.0216 0.1047
Mycobacterium ulcerans lipase LipD 0.015 0.0339 0.0869
Mycobacterium tuberculosis Probable lipase LipD 0.015 0.0339 0.0869
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0006 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0006 0.0005
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0058 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0087 0.2091
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0054 0.1291
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0054 0.0169
Onchocerca volvulus 0.0016 0.0006 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0339 0.1419
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0058 0.0226
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0006 0.0097
Echinococcus multilocularis thyroid hormone receptor alpha 0.005 0.0088 0.0084
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0058 0.1376
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0224
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0062 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0088 0.0428
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0037
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0006 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0088 0.0428
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0054 0.0169
Echinococcus multilocularis lamin 0.0082 0.0168 0.0164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Mycobacterium tuberculosis Probable reductase 0.0105 0.0226 0.0576
Plasmodium vivax glutathione reductase, putative 0.0046 0.0079 0.1848
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0008 0.0008
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0057 0.0662
Mycobacterium tuberculosis Probable esterase LipL 0.015 0.0339 0.0869
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0088 0.0428
Trypanosoma brucei trypanothione reductase 0.0046 0.0079 0.1907
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0109 0.0236 0.0602
Schistosoma mansoni zinc finger protein 0.0023 0.0023 0.0075
Loa Loa (eye worm) MH2 domain-containing protein 0.0375 0.0897 0.434
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0054 0.018
Echinococcus granulosus Smad4 0.0026 0.0028 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0121 0.0267 0.09
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0121 0.0267 0.0262
Schistosoma mansoni alpha-glucosidase 0.0144 0.0323 0.1091
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0088 0.0428
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0023 0.0023 0.0075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0329 0.0781 0.2646
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0079 0.1848
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0022 0.0046
Plasmodium vivax vivapain-2 0.0016 0.0006 0.0026
Brugia malayi hypothetical protein 0.0159 0.036 0.1742
Giardia lamblia PHD finger protein 15 0.0031 0.0042 0.7
Echinococcus multilocularis cysteine protease 0.0016 0.0006 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0088 0.0084
Toxoplasma gondii cathepsin CPL 0.0016 0.0006 0.0026
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0216 0.0212
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0006 0.0015
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0088 0.0366
Mycobacterium leprae conserved hypothetical protein 0.015 0.0339 0.0827
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Brugia malayi nuclear receptor NHR-88 0.0023 0.0023 0.0112
Brugia malayi Thioredoxin reductase 0.0046 0.0079 0.0383
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.003 0.0087
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0123 0.0597
Schistosoma mansoni alpha-glucosidase 0.0144 0.0323 0.1091
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0022 0.0046
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.012 0.2906
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0098 0.0207 0.0528
Mycobacterium ulcerans beta-lactamase 0.015 0.0339 0.0869
Brugia malayi nuclear receptor NHR-67 0.0023 0.0023 0.0112
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.015 0.0339 0.0869
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0108 0.0352
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0097
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0058 1
Echinococcus granulosus lamin dm0 0.0082 0.0168 0.0555
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0329 0.0781 0.3779
Echinococcus multilocularis musashi 0.0082 0.0168 0.0164
Plasmodium vivax SET domain protein, putative 0.0121 0.0267 0.6481
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0008 0.0078
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0226 0.0576
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0058 0.1314
Leishmania major hypothetical protein, conserved 0.015 0.0339 0.8275
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0022 0.0107
Mycobacterium tuberculosis Probable lipase LipE 0.015 0.0339 0.0869
Schistosoma mansoni nuclear receptor nhr-48 0.0023 0.0023 0.0075
Echinococcus granulosus tumor protein p63 0.0676 0.1645 0.557
Echinococcus multilocularis smad 0.0026 0.0028 0.0024
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0057 0.0276
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0057 0.0224
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0058 0.1314
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.0236 0.5754
Echinococcus granulosus inositol monophosphatase 1 0.0109 0.0236 0.0786
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0004 0.0071
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0088 0.0084
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0057 0.0224
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0006 0.0015
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0023 0.0023 0.0112
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0202
Loa Loa (eye worm) hypothetical protein 0.0099 0.0211 0.1019
Trichomonas vaginalis inositol monophosphatase, putative 0.0109 0.0236 0.0983
Loa Loa (eye worm) hypothetical protein 0.015 0.0339 0.1637
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0023 0.0023 0.0075
Loa Loa (eye worm) ctsf protein 0.0016 0.0006 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Loa Loa (eye worm) hypothetical protein 0.0064 0.0123 0.0595
Echinococcus granulosus lamin 0.0082 0.0168 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0088 0.0428
Onchocerca volvulus 0.0016 0.0006 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Mycobacterium ulcerans esterase/lipase LipP 0.015 0.0339 0.0869
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.0236 0.5754
Echinococcus multilocularis tumor protein p63 0.0676 0.1645 0.1641
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0063 0.0058
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0028 0.0081
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0226 0.0532
Plasmodium falciparum phd finger protein, putative 0.0031 0.0042 0.092
Brugia malayi hypothetical protein 0.0026 0.003 0.0146
Loa Loa (eye worm) fli-1 protein 0.0226 0.0526 0.2545
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0138 0.0307 0.1039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0005 0.0002
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0058 0.0138
Brugia malayi Smad1 0.0026 0.0028 0.0137
Brugia malayi MH2 domain containing protein 0.0026 0.0028 0.0137
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.015 0.0145
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0028 0.0081
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0023 0.0089
Echinococcus granulosus thyroid hormone receptor alpha 0.0023 0.0023 0.0063
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0109 0.0236 0.2955
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0014 0.007
Mycobacterium ulcerans hypothetical protein 0.0023 0.0022 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0255 0.0651
Loa Loa (eye worm) TAR-binding protein 0.0256 0.0601 0.2905
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0054 0.005
Brugia malayi nuclear receptor RXR 0.0023 0.0023 0.0112
Mycobacterium tuberculosis Conserved protein 0.015 0.0339 0.0869
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.015 0.0339 0.1637
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0107
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0088 0.0428
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0097
Echinococcus granulosus histone lysine methyltransferase setb 0.0138 0.0307 0.1028
Brugia malayi Bromodomain containing protein 0.0037 0.0057 0.0275
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0226 0.0576
Echinococcus granulosus tar DNA binding protein 0.0256 0.0601 0.2024
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0006 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0601 0.2033
Mycobacterium tuberculosis Probable conserved lipoprotein 0.015 0.0339 0.0869
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0004 0.0071
Onchocerca volvulus 0.005 0.0088 0.0366
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.0236 0.5754
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0097
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0023 0.0019
Brugia malayi nuclear hormone receptor family member nhr-6 0.0023 0.0023 0.0112
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0023 0.0063
Schistosoma mansoni gabp alpha 0.0074 0.015 0.0504
Plasmodium vivax hypothetical protein, conserved 0.015 0.0339 0.8263
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0054 0.1291
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0006 0.0001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0079 0.0075
Echinococcus granulosus geminin 0.1201 0.295 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0023 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0088 0.0428
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0071
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0006 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0098 0.0207 0.0485
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0226 0.0576
Trypanosoma cruzi PAB1-binding protein , putative 0.0179 0.0409 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0088 0.0285
Schistosoma mansoni nuclear receptor 0.0023 0.0023 0.0075
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.003 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0088 0.0428
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0058 0.1376
Loa Loa (eye worm) Smad1 0.0026 0.0028 0.0137
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0028 0.0024
Onchocerca volvulus 0.0097 0.0206 0.0867
Loa Loa (eye worm) hypothetical protein 0.015 0.0339 0.1637
Brugia malayi MH1 domain containing protein 0.0026 0.0028 0.0137
Trypanosoma brucei glucosidase, putative 0.0037 0.0057 0.1365
Onchocerca volvulus 0.0963 0.2358 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0088 0.0428
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0054 0.0211
Loa Loa (eye worm) RNA binding protein 0.0256 0.0601 0.2905
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0004 0.0071
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0023 0.0112
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0125 0.0276 0.0271
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0022 0.0046
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0256 0.0601 0.2905
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0088 0.0366
Onchocerca volvulus 0.0016 0.0006 0.0015
Entamoeba histolytica hypothetical protein 0.033 0.0785 1
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1562 0.3847 1
Schistosoma mansoni hypothetical protein 0.0097 0.0206 0.0696
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.008 0.0164 0.016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0088 0.0296
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0088 0.0428
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0329 0.0781 0.2638
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.033 0.0785 0.0781
Schistosoma mansoni alpha glucosidase 0.0037 0.0057 0.019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0004 0.0071
Loa Loa (eye worm) hypothetical protein 0.015 0.0339 0.1637
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0074 0.0356
Onchocerca volvulus 0.0082 0.0168 0.0704
Brugia malayi ecdysteroid receptor 0.005 0.0088 0.0428
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0023 0.0075
Brugia malayi MH1 domain containing protein 0.0026 0.0028 0.0137
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0022 0.0213
Schistosoma mansoni smad1 5 8 and 0.0026 0.0028 0.0093
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Toxoplasma gondii ABC1 family protein 0.015 0.0339 0.8263
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0054 0.0623
Onchocerca volvulus 0.0023 0.0023 0.0089
Brugia malayi ecdysone receptor 0.0023 0.0023 0.0112
Echinococcus multilocularis peregrin 0.0033 0.0047 0.0043
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0088 0.0084
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0007 0.0035
Loa Loa (eye worm) hypothetical protein 0.0041 0.0067 0.0325
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Plasmodium falciparum glutathione reductase 0.0046 0.0079 0.1848
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0042 0.092
Schistosoma mansoni ets-related 0.0226 0.0526 0.1781
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0088 0.0285
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.015 0.0339 0.1144
Echinococcus granulosus survival motor neuron protein 1 0.0476 0.1149 0.3884
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0037
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0109 0.0236 0.5724
Brugia malayi hypothetical protein 0.0476 0.1149 0.5555
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0057 0.0224
Brugia malayi RNA binding protein 0.0256 0.0601 0.2905
Schistosoma mansoni nuclear receptor 0.0023 0.0023 0.0075
Loa Loa (eye worm) hypothetical protein 0.0039 0.0063 0.0303
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0339 0.1419
Brugia malayi steroid hormone receptor 0.005 0.0088 0.0428
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0601 0.2033
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0088 0.0428
Mycobacterium tuberculosis Conserved protein 0.015 0.0339 0.0869
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0062 0.0208
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0004 0.0071
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0262
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0005 0.0002
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0006 0.0004
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0051 0.0158
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.033 0.0785 0.265
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0022 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0054 0.0262
Schistosoma mansoni hypothetical protein 0.1201 0.295 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0019 0.0014
Echinococcus granulosus intermediate filament protein 0.0082 0.0168 0.0555
Mycobacterium ulcerans TetR family transcriptional regulator 0.1562 0.3847 1
Schistosoma mansoni hypothetical protein 0.0031 0.0042 0.0138
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.003 0.0099
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.015 0.0339 0.1637
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0054 0.018
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.003 0.0146
Brugia malayi beta-lactamase 0.015 0.0339 0.1637
Schistosoma mansoni intermediate filament proteins 0.0082 0.0168 0.0566
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0267 0.09
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0224
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0211 0.0711
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.003 0.0099
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Schistosoma mansoni hypothetical protein 0.0125 0.0276 0.0931
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.008 0.0164 0.0541
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0006 0.0097
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0006 0.0026
Brugia malayi nuclear receptor RXR 0.0026 0.003 0.0146
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0051 0.0047
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0108 0.0104
Loa Loa (eye worm) transcription factor SMAD2 0.0375 0.0897 0.434
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0019 0.0049
Schistosoma mansoni hypothetical protein 0.027 0.0636 0.2154
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0058 0.0053
Loa Loa (eye worm) hypothetical protein 0.0125 0.0276 0.1333
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0006 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi hypothetical protein 0.0023 0.0023 0.0112
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0058 0.0668
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Trypanosoma cruzi PAB1-binding protein , putative 0.0179 0.0409 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0395 0.0947 0.4579
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0006 0.0015
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0088 0.0285
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Loa Loa (eye worm) DR-78 0.0023 0.0023 0.0112
Loa Loa (eye worm) hypothetical protein 0.0082 0.0168 0.0812
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0023 0.0112
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0023 0.0019
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0006 0.0001
Echinococcus granulosus microtubule associated protein 2 0.075 0.1829 0.6192
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0006 0.0004
Brugia malayi beta-lactamase family protein 0.015 0.0339 0.1637
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0008 0.0078
Onchocerca volvulus 0.0016 0.0006 0.0015
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0088 0.0296
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.0381 0.1842
Schistosoma mansoni inositol monophosphatase 0.0109 0.0236 0.0796
Mycobacterium tuberculosis Conserved protein 0.015 0.0339 0.0869
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0088 0.0428
Schistosoma mansoni zinc finger protein 0.0015 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.015 0.0339 0.1637
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0088 0.0428
Onchocerca volvulus 0.0016 0.0006 0.0015
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0023 0.0023 0.0112
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.015 0.0724
Loa Loa (eye worm) cysteine protease 0.0016 0.0006 0.0027
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.015 0.0493
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0107
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0109 0.0236 1
Onchocerca volvulus 0.0121 0.0267 0.1122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0088 0.0084
Loa Loa (eye worm) inositol-1 0.0109 0.0236 0.1141
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Schistosoma mansoni hypothetical protein 0.0125 0.0276 0.0931
Loa Loa (eye worm) hypothetical protein 0.0159 0.036 0.1742
Echinococcus granulosus peregrin 0.0033 0.0047 0.0146
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0109 0.0236 0.0983
Loa Loa (eye worm) hypothetical protein 0.015 0.0339 0.1637
Leishmania major cathepsin L-like protease 0.0062 0.012 0.2906
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0088 0.0296
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.0339 0.8275
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0216 0.072
Brugia malayi jmjC domain containing protein 0.0039 0.0062 0.0302
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0088 0.0428
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0329 0.0781 0.0777
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.0381 0.1842
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0381 0.0377
Echinococcus multilocularis survival motor neuron protein 1 0.0476 0.1149 0.1145
Toxoplasma gondii LsmAD domain-containing protein 0.0179 0.0409 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0088 0.0296
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0079 0.1907
Plasmodium falciparum ataxin-2 like protein, putative 0.0179 0.0409 1
Loa Loa (eye worm) glutathione reductase 0.0046 0.0079 0.0383
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0961 0.2352 0.6109
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0088 0.0428
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0023 0.0023 0.0019
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0023 0.0089
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0058 0.1376
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.0255 0.0852
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0062 0.0197
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0276
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0088 0.0428
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0023 0.0019
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0121 0.0267 0.6481
Schistosoma mansoni hypothetical protein 0.0125 0.0276 0.0931
Brugia malayi RNA recognition motif domain containing protein 0.0256 0.0601 0.2905
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0601 0.2033
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0042 0.0126
Brugia malayi hypothetical protein 0.0023 0.0023 0.0112
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0255 0.0651
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0023 0.0063
Echinococcus multilocularis cysteine protease 0.0016 0.0006 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0138 0.0307 0.0303
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0846 0.2068 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0022 0.0046
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0107
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0004 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0022 0.0046
Schistosoma mansoni smad1 5 8 and 0.0026 0.0028 0.0093
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0022 0.0505
Brugia malayi Bromodomain containing protein 0.0033 0.0047 0.0229
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.0381 0.1278
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1562 0.3847 1
Schistosoma mansoni bromodomain containing protein 0.0061 0.0117 0.0392
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0057 0.1303
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0008 0.0008
Brugia malayi PHD-finger family protein 0.0031 0.0042 0.0202
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0058 0.018
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0006 0.0016
Brugia malayi Ets-domain containing protein 0.0074 0.015 0.0724
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0395 0.0947 0.4579
Schistosoma mansoni thyroid hormone receptor 0.005 0.0088 0.0296
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0022 0.0107
Schistosoma mansoni hypothetical protein 0.1201 0.295 1
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0168 0.0812
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0088 0.0428
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0022 0.0213
Brugia malayi nuclear hormone receptor 0.005 0.0088 0.0428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0022 0.0046
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0226 0.0576
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0146
Onchocerca volvulus 0.015 0.0339 0.1428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0168 0.0812
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0224
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0125 0.0276 0.092
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0058 0.0226
Schistosoma mansoni hypothetical protein 0.008 0.0164 0.0552
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0088 0.0428
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Echinococcus multilocularis beta LACTamase domain containing family member 0.015 0.0339 0.0334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0037
Schistosoma mansoni smad1 5 8 and 0.0026 0.0028 0.0093
Loa Loa (eye worm) hypothetical protein 0.0476 0.1149 0.5555
Loa Loa (eye worm) hypothetical protein 0.0039 0.0063 0.0304
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0329 0.0781 0.2638
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0004 0.0071
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0057 0.0276
Loa Loa (eye worm) nuclear hormone receptor 0.0023 0.0023 0.0112
Mycobacterium ulcerans transcriptional regulator 0.1562 0.3847 1
Leishmania major hypothetical protein, conserved 0.0179 0.0409 1
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.003 0.0146
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.0236 0.5754
Schistosoma mansoni ap endonuclease 0.0037 0.0058 0.0192
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0006 0.0004
Mycobacterium leprae Probable lipase LipE 0.015 0.0339 0.0827
Entamoeba histolytica hypothetical protein 0.033 0.0785 1
Onchocerca volvulus 0.015 0.0339 0.1428
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0058 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0088 0.0084
Echinococcus granulosus beta LACTamase domain containing family member 0.015 0.0339 0.1134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0088 0.0366
Schistosoma mansoni hypothetical protein 0.033 0.0785 0.2658
Echinococcus multilocularis lamin dm0 0.0082 0.0168 0.0164
Loa Loa (eye worm) hypothetical protein 0.0068 0.0135 0.0651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0088 0.0428
Brugia malayi Inositol-1 0.0109 0.0236 0.1141
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0023 0.0075
Plasmodium falciparum ataxin-2 like protein, putative 0.0179 0.0409 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0008 1
Brugia malayi hypothetical protein 0.0115 0.0251 0.1216
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.003 0.0026
Plasmodium vivax vivapain-2 0.0016 0.0006 0.0026
Mycobacterium ulcerans hypothetical protein 0.015 0.0339 0.0869
Echinococcus multilocularis microtubule associated protein 2 0.075 0.1829 0.1825
Echinococcus multilocularis geminin 0.1201 0.295 0.2947
Onchocerca volvulus 0.0159 0.036 0.152
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0088 0.0285
Schistosoma mansoni hypothetical protein 0.0125 0.0276 0.0931
Brugia malayi TAR-binding protein 0.0256 0.0601 0.2905
Leishmania major cathepsin L-like protease 0.0062 0.012 0.2906
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi intermediate filament protein 0.0082 0.0168 0.0812
Entamoeba histolytica hypothetical protein 0.033 0.0785 1
Plasmodium vivax ataxin-2 like protein, putative 0.0179 0.0409 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.015 0.0339 0.0869
Brugia malayi conserved hypotetical protein 0.0023 0.0023 0.0112
Echinococcus multilocularis inositol monophosphatase 1 0.0109 0.0236 0.0231
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0255 0.0651
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.012 0.2906
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0063 0.0198
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0146
Plasmodium falciparum thioredoxin reductase 0.0046 0.0079 0.1848
Loa Loa (eye worm) hypothetical protein 0.0038 0.0059 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0088 0.0428
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0088 0.0285
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0097
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.015 0.0339 0.0869
Loa Loa (eye worm) hypothetical protein 0.015 0.0339 0.1637
Leishmania major cathepsin L-like protease 0.0062 0.012 0.2906
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0329 0.0781 0.2646
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0146
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0023 0.0023 0.0019
Schistosoma mansoni microtubule-associated protein tau 0.075 0.1829 0.6197
Schistosoma mansoni thyroid hormone receptor 0.005 0.0088 0.0296
Brugia malayi hypothetical protein 0.0026 0.003 0.0146
Trichomonas vaginalis penicillin-binding protein, putative 0.015 0.0339 0.1419
Brugia malayi follicle stimulating hormone receptor 0.0692 0.1684 0.8145
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0109 0.0236 0.0983
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0168 0.0812
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0072 0.0067
Brugia malayi Pre-SET motif family protein 0.0846 0.2068 1
Brugia malayi Ets-domain containing protein 0.0074 0.015 0.0724
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0054 0.0211
Echinococcus multilocularis nuclear receptor nhr 48 0.0023 0.0023 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0088 0.0428
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0054 0.005
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0329 0.0781 0.0777
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0059 0.0286
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1562 0.3847 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0179 0.0409 0.1977
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0054 0.005
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0028 0.0093
Schistosoma mansoni coup transcription factor 0.005 0.0088 0.0296
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.012 0.2906
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0601 0.2033
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0057 0.0224
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Onchocerca volvulus 0.0023 0.0022 0.0085
Schistosoma mansoni hypothetical protein 0.0015 0.0002 0.0002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0058 0.0279
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0057 0.1365
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0005 0.0002
Brugia malayi MH2 domain containing protein 0.0375 0.0897 0.434
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0054 0.0211
Brugia malayi nuclear receptor NHR-88 0.005 0.0088 0.0428
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0329 0.0781 0.2646
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0004 0.0071
Schistosoma mansoni lamin 0.0082 0.0168 0.0566
Brugia malayi PHD-finger family protein 0.0024 0.0025 0.0119
Schistosoma mansoni smad 0.0026 0.0028 0.0093
Onchocerca volvulus 0.015 0.0339 0.1428
Brugia malayi beta-lactamase family protein 0.015 0.0339 0.1637
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0339 0.1419
Trichomonas vaginalis esterase, putative 0.015 0.0339 0.1419
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0088 0.0296
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0088 0.0285
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0058 0.0138
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0072 0.0228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0079 0.0194
Schistosoma mansoni zinc finger protein 0.0019 0.0012 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0057 0.1365
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0058 0.1376
Onchocerca volvulus 0.0082 0.0168 0.0704
Onchocerca volvulus 0.0023 0.0023 0.0089
Brugia malayi tailless protein 0.0023 0.0023 0.0112
Echinococcus granulosus FTZ F1 alpha 0.005 0.0088 0.0285
Onchocerca volvulus 0.0097 0.0205 0.0863
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0022 0.0107
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0022 0.0213
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0022 0.0505
Loa Loa (eye worm) nuclear receptor NHR-67 0.0023 0.0023 0.0112

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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