Detailed information for compound 1311944

Basic information

Technical information
  • TDR Targets ID: 1311944
  • Name: N-(2-methylphenyl)-1-oxo-4-phenylisochromene- 3-carboxamide
  • MW: 355.386 | Formula: C23H17NO3
  • H donors: 1 H acceptors: 2 LogP: 4.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1NC(=O)c1oc(=O)c2c(c1c1ccccc1)cccc2
  • InChi: 1S/C23H17NO3/c1-15-9-5-8-14-19(15)24-22(25)21-20(16-10-3-2-4-11-16)17-12-6-7-13-18(17)23(26)27-21/h2-14H,1H3,(H,24,25)
  • InChiKey: CHQLBTMMAZLDHG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-methylphenyl)-1-oxo-4-phenyl-isochromene-3-carboxamide
  • N-(2-methylphenyl)-1-oxo-4-phenyl-3-isochromenecarboxamide
  • 1-keto-N-(2-methylphenyl)-4-phenyl-isochromene-3-carboxamide
  • MLS000583167
  • N-(2-methylphenyl)-1-oxo-4-phenyl-1H-isochromene-3-carboxamide
  • SMR000206353
  • Oprea1_692126

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.015 0.0724
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0057 0.1365
Schistosoma mansoni intermediate filament proteins 0.0082 0.0168 0.0566
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Echinococcus granulosus survival motor neuron protein 1 0.0476 0.1149 0.3884
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0395 0.0947 0.4579
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0058 0.1376
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0022 0.0107
Trypanosoma cruzi PAB1-binding protein , putative 0.0179 0.0409 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0054 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi nuclear receptor RXR 0.0026 0.003 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0088 0.0428
Mycobacterium tuberculosis Probable reductase 0.0105 0.0226 0.0576
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0058 0.0668
Trypanosoma brucei hypothetical protein, conserved 0.015 0.0339 0.8275
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.008 0.0164 0.0541
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.015 0.0339 0.1637
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0072 0.0067
Schistosoma mansoni nuclear hormone receptor 0.005 0.0088 0.0296
Brugia malayi MH1 domain containing protein 0.0026 0.0028 0.0137
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0006 0.0097
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.003 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi jmjC domain containing protein 0.0039 0.0062 0.0302
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.003 0.0087
Schistosoma mansoni alpha-glucosidase 0.0144 0.0323 0.1091
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0058 1
Schistosoma mansoni hypothetical protein 0.002 0.0014 0.0045
Loa Loa (eye worm) ctsf protein 0.0016 0.0006 0.0027
Onchocerca volvulus 0.0082 0.0168 0.0704
Onchocerca volvulus 0.015 0.0339 0.1428
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0028 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0226 0.0576
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0057 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0088 0.0428
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0022 0.0505
Echinococcus granulosus zinc finger protein 0.0019 0.0012 0.0025
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0211 0.0711
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0005 0.0002
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0054 0.1291
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0088 0.0296
Brugia malayi Bromodomain containing protein 0.0037 0.0057 0.0275
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0088 0.0296
Loa Loa (eye worm) glutathione reductase 0.0046 0.0079 0.0383
Schistosoma mansoni hypothetical protein 0.0125 0.0276 0.0931
Echinococcus multilocularis beta LACTamase domain containing family member 0.015 0.0339 0.0334
Loa Loa (eye worm) hypothetical protein 0.0476 0.1149 0.5555
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0071
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0023 0.0023 0.0075
Brugia malayi hypothetical protein 0.0023 0.0023 0.0112
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0146
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0146
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0088 0.0084
Mycobacterium ulcerans TetR family transcriptional regulator 0.1562 0.3847 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0329 0.0781 0.0777
Brugia malayi nuclear hormone receptor family member odr-7 0.0023 0.0023 0.0112
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0058 0.1376
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0006 0.0001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0059 0.0286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0097
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0042 0.092
Toxoplasma gondii ABC1 family protein 0.015 0.0339 0.8263
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0088 0.0296
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Echinococcus granulosus tumor protein p63 0.0676 0.1645 0.557
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.012 0.2906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Leishmania major hypothetical protein, conserved 0.0179 0.0409 1
Mycobacterium tuberculosis Conserved protein 0.015 0.0339 0.0869
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0058 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0037
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0004 0.0071
Plasmodium vivax vivapain-2 0.0016 0.0006 0.0026
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0062 0.0208
Giardia lamblia PHD finger protein 15 0.0031 0.0042 0.7
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0022 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0054 0.0211
Mycobacterium tuberculosis Probable esterase LipL 0.015 0.0339 0.0869
Plasmodium falciparum ataxin-2 like protein, putative 0.0179 0.0409 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0057 0.0276
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0022 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Schistosoma mansoni hypothetical protein 0.1201 0.295 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0692 0.1684 0.8145
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1562 0.3847 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0395 0.0947 0.4579
Echinococcus granulosus lamin dm0 0.0082 0.0168 0.0555
Loa Loa (eye worm) hypothetical protein 0.015 0.0339 0.1637
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0054 0.018
Loa Loa (eye worm) beta-lactamase 0.015 0.0339 0.1637
Brugia malayi hypothetical protein 0.0476 0.1149 0.5555
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Loa Loa (eye worm) hypothetical protein 0.008 0.0164 0.0794
Brugia malayi nuclear receptor RXR 0.0023 0.0023 0.0112
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0054 0.1291
Onchocerca volvulus 0.0016 0.0006 0.0015
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0042 0.0037
Loa Loa (eye worm) hypothetical protein 0.0159 0.036 0.1742
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0088 0.0428
Loa Loa (eye worm) TAR-binding protein 0.0256 0.0601 0.2905
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0601 0.2033
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0224
Brugia malayi nuclear receptor NHR-88 0.005 0.0088 0.0428
Plasmodium falciparum thioredoxin reductase 0.0046 0.0079 0.1848
Echinococcus granulosus thyroid hormone receptor alpha 0.0023 0.0023 0.0063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Schistosoma mansoni hypothetical protein 0.0125 0.0276 0.0931
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0146
Schistosoma mansoni thyroid hormone receptor 0.005 0.0088 0.0296
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0108 0.0104
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0109 0.0236 0.0983
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Loa Loa (eye worm) hypothetical protein 0.0082 0.0168 0.0812
Loa Loa (eye worm) hypothetical protein 0.0038 0.0059 0.0286
Echinococcus multilocularis zinc finger protein 0.0019 0.0012 0.0007
Echinococcus granulosus tar DNA binding protein 0.0256 0.0601 0.2024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0329 0.0781 0.2646
Echinococcus granulosus nuclear receptor nhr 48 0.0023 0.0023 0.0063
Echinococcus granulosus Smad4 0.0026 0.0028 0.0081
Brugia malayi intermediate filament protein 0.0082 0.0168 0.0812
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0601 0.2033
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0098 0.0207 0.0485
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0004 0.0071
Echinococcus multilocularis microtubule associated protein 2 0.075 0.1829 0.1825
Echinococcus multilocularis lamin dm0 0.0082 0.0168 0.0164
Trypanosoma brucei PAB1-binding protein , putative 0.0179 0.0409 1
Echinococcus multilocularis Smad4 0.0026 0.0028 0.0024
Schistosoma mansoni Smad4 0.0026 0.0028 0.0093
Mycobacterium ulcerans lipase LipD 0.015 0.0339 0.0869
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0088 0.0366
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0202
Brugia malayi nuclear receptor NHR-88 0.0023 0.0023 0.0112
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.0381 0.1842
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0123 0.0597
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0088 0.0285
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0088 0.0285
Echinococcus multilocularis musashi 0.0082 0.0168 0.0164
Loa Loa (eye worm) hypothetical protein 0.0138 0.0307 0.1487
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.0339 0.8275
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0004 0.0071
Loa Loa (eye worm) hypothetical protein 0.015 0.0339 0.1637
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Schistosoma mansoni alpha glucosidase 0.0037 0.0057 0.019
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0006 0.0015
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.015 0.0493
Onchocerca volvulus 0.015 0.0339 0.1428
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0037
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0074 0.0356
Echinococcus granulosus lamin 0.0082 0.0168 0.0555
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0022 0.0046
Loa Loa (eye worm) hypothetical protein 0.015 0.0339 0.1637
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.015 0.0339 0.1637
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0006 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Onchocerca volvulus 0.0016 0.0006 0.0015
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0058 0.1314
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.012 0.2906
Loa Loa (eye worm) hypothetical protein 0.0041 0.0067 0.0325
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0224
Leishmania major hypothetical protein, conserved 0.015 0.0339 0.8275
Brugia malayi Inositol-1 0.0109 0.0236 0.1141
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0109 0.0236 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0058 0.0138
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Onchocerca volvulus 0.0023 0.0023 0.0089
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0098 0.0207 0.0528
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0088 0.0285
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0022 0.0213
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Brugia malayi conserved hypotetical protein 0.0023 0.0023 0.0112
Loa Loa (eye worm) hypothetical protein 0.0064 0.0123 0.0595
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0255 0.0651
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0023 0.0023 0.0019
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0054 0.1291
Onchocerca volvulus 0.0099 0.0211 0.0886
Brugia malayi Calcitonin receptor-like protein seb-1 0.0395 0.0947 0.4579
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0028 0.0024
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Leishmania major trypanothione reductase 0.0046 0.0079 0.1907
Schistosoma mansoni nuclear receptor 0.0023 0.0023 0.0075
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0006 0.0004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0058 0.1314
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0022 0.0213
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0088 0.0296
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0005 0.0002
Brugia malayi nuclear hormone receptor 0.0023 0.0023 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0006 0.0015
Echinococcus granulosus histone lysine methyltransferase setb 0.0138 0.0307 0.1028
Echinococcus granulosus geminin 0.1201 0.295 1
Brugia malayi tailless protein 0.0023 0.0023 0.0112
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0106 0.2575
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.015 0.0339 0.1144
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0125 0.0276 0.092
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0381 0.0377
Brugia malayi beta-lactamase 0.015 0.0339 0.1637
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0121 0.0267 0.0262
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0022 0.0046
Echinococcus multilocularis tumor protein p63 0.0676 0.1645 0.1641
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.003 0.0146
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0006 0.0016
Loa Loa (eye worm) fibroinase 0.0016 0.0006 0.0027
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0054 0.0169
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0125 0.0276 0.1333
Mycobacterium ulcerans esterase/lipase LipP 0.015 0.0339 0.0869
Loa Loa (eye worm) nuclear receptor NHR-67 0.0023 0.0023 0.0112
Loa Loa (eye worm) hypothetical protein 0.0099 0.0211 0.1019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0961 0.2352 0.6109
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0097
Toxoplasma gondii exonuclease III APE 0.0037 0.0058 0.1314
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0329 0.0781 0.3779
Brugia malayi MH2 domain containing protein 0.0026 0.0028 0.0137
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0224
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0023 0.0019
Schistosoma mansoni survival motor neuron protein 0.0097 0.0206 0.0696
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0088 0.0296
Mycobacterium tuberculosis Conserved protein 0.015 0.0339 0.0869
Loa Loa (eye worm) RNA binding protein 0.0256 0.0601 0.2905
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0088 0.0428
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0023 0.0089
Brugia malayi nuclear receptor NHR-67 0.0023 0.0023 0.0112
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0062 0.0208
Brugia malayi glutathione reductase 0.0046 0.0079 0.0383
Loa Loa (eye worm) fli-1 protein 0.0226 0.0526 0.2545
Plasmodium falciparum ataxin-2 like protein, putative 0.0179 0.0409 1
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0006 0.0027
Plasmodium vivax vivapain-2 0.0016 0.0006 0.0026
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0057 0.1303
Echinococcus multilocularis inositol monophosphatase 1 0.0109 0.0236 0.0231
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0006 0.0001
Loa Loa (eye worm) cysteine protease 0.0016 0.0006 0.0027
Schistosoma mansoni bromodomain containing protein 0.0061 0.0117 0.0392
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Onchocerca volvulus 0.0023 0.0022 0.0085
Trypanosoma cruzi PAB1-binding protein , putative 0.0179 0.0409 1
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.0339 0.8275
Schistosoma mansoni gabp alpha 0.0074 0.015 0.0504
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0062 0.0302
Onchocerca volvulus 0.0016 0.0006 0.0015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0329 0.0781 0.2646
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0023 0.0023 0.0019
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0019 0.0049
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.015 0.0339 0.0869
Echinococcus granulosus FTZ F1 alpha 0.005 0.0088 0.0285
Trypanosoma brucei trypanothione reductase 0.0046 0.0079 0.1907
Onchocerca volvulus 0.005 0.0088 0.0366
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0601 0.2033
Schistosoma mansoni hypothetical protein 0.1201 0.295 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0037
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0088 0.0296
Schistosoma mansoni ets-related 0.0226 0.0526 0.1781
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0006 0.0004
Schistosoma mansoni hypothetical protein 0.008 0.0164 0.0552
Trichomonas vaginalis penicillin-binding protein, putative 0.015 0.0339 0.1419
Echinococcus multilocularis peregrin 0.0033 0.0047 0.0043
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.012 0.2906
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0329 0.0781 0.2646
Brugia malayi MH2 domain containing protein 0.0375 0.0897 0.434
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0042 0.092
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0054 0.0211
Schistosoma mansoni hypothetical protein 0.0125 0.0276 0.0931
Schistosoma mansoni ap endonuclease 0.0037 0.0058 0.0192
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0088 0.0084
Brugia malayi orphan nuclear receptor NR2E1 0.0023 0.0023 0.0112
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0088 0.0296
Loa Loa (eye worm) hypothetical protein 0.015 0.0339 0.1637
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0057 0.0224
Brugia malayi Thioredoxin reductase 0.0046 0.0079 0.0383
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0224
Schistosoma mansoni zinc finger protein 0.0015 0.0002 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0329 0.0781 0.2638
Schistosoma mansoni thyroid hormone receptor 0.005 0.0088 0.0296
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0023 0.0063
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0088 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Brugia malayi MH1 domain containing protein 0.0026 0.0028 0.0137
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0088 0.0428
Loa Loa (eye worm) hypothetical protein 0.027 0.0636 0.3077
Echinococcus multilocularis cysteine protease 0.0016 0.0006 0.0001
Loa Loa (eye worm) nuclear hormone receptor 0.0023 0.0023 0.0112
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0004 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi MH2 domain containing protein 0.0026 0.0028 0.0137
Brugia malayi steroid hormone receptor 0.005 0.0088 0.0428
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0006 0.0001
Brugia malayi follicle stimulating hormone receptor 0.0692 0.1684 0.8145
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0006 0.0027
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0088 0.0428
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0074 0.0356
Onchocerca volvulus 0.0016 0.0006 0.0015
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0079 0.0075
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0057 0.0179
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0058 0.0053
Schistosoma mansoni lamin 0.0082 0.0168 0.0566
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0079 0.0194
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0063 0.0058
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0088 0.0285
Loa Loa (eye worm) hypothetical protein 0.015 0.0339 0.1637
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0146
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0088 0.0428
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Echinococcus granulosus inositol monophosphatase 1 0.0109 0.0236 0.0786
Schistosoma mansoni jumonji domain containing protein 0.008 0.0165 0.0555
Brugia malayi Bromodomain containing protein 0.0072 0.0145 0.0701
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0088 0.0428
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0088 0.0296
Loa Loa (eye worm) hypothetical protein 0.0395 0.0947 0.4579
Echinococcus multilocularis GPCR, family 2 0.0125 0.0276 0.0271
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0019 0.0014
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0019 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0088 0.0428
Schistosoma mansoni ap endonuclease 0.0037 0.0058 0.0192
Brugia malayi beta-lactamase family protein 0.015 0.0339 0.1637
Onchocerca volvulus 0.0159 0.036 0.152
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0027
Brugia malayi jmjC domain containing protein 0.0101 0.0216 0.1047
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0054 0.0623
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0008 0.0078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0023 0.0019
Plasmodium vivax ataxin-2 like protein, putative 0.0179 0.0409 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0262
Schistosoma mansoni inositol monophosphatase 0.0109 0.0236 0.0796
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.0236 0.5754
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.003 0.0099
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0226 0.0576
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0023 0.0023 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Schistosoma mansoni lamin 0.0082 0.0168 0.0566
Brugia malayi Pre-SET motif family protein 0.0846 0.2068 1
Onchocerca volvulus 0.0016 0.0006 0.0015
Brugia malayi nuclear hormone receptor family member nhr-6 0.0023 0.0023 0.0112
Loa Loa (eye worm) latrophilin receptor protein 2 0.0125 0.0276 0.1333
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0057 0.0276
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Brugia malayi hypothetical protein 0.0026 0.003 0.0146
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0109 0.0236 0.5724
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Schistosoma mansoni smad1 5 8 and 0.0026 0.0028 0.0093
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0058 0.0226
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.0381 0.1278
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0037
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0054 0.0262
Schistosoma mansoni transcription factor LCR-F1 0.033 0.0785 0.2658
Leishmania major cathepsin L-like protease 0.0062 0.012 0.2906
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0058 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0138 0.0307 0.1039
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0006 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0088 0.0428
Onchocerca volvulus 0.0016 0.0006 0.0015
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0023 0.0023 0.0112
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0022 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0088 0.0428
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0054 0.1291
Schistosoma mansoni coup transcription factor 0.005 0.0088 0.0296
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0168 0.0812
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0062 0.0197
Entamoeba histolytica hypothetical protein 0.033 0.0785 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Schistosoma mansoni nuclear receptor 0.0023 0.0023 0.0075
Leishmania major cathepsin L-like protease 0.0062 0.012 0.2906
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0079 0.0254
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0108 0.0352
Leishmania major cathepsin L-like protease 0.0062 0.012 0.2906
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0058 0.0226
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0097
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0057 0.0662
Schistosoma mansoni hypothetical protein 0.0015 0.0002 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0022 0.0046
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0022 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0023 0.0075
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0168 0.0812
Schistosoma mansoni smad 0.0026 0.0028 0.0093
Entamoeba histolytica hypothetical protein 0.033 0.0785 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0006 0.0027
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.003 0.0099
Schistosoma mansoni hypothetical protein 0.0125 0.0276 0.0931
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0088 0.0428
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0006 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0107
Loa Loa (eye worm) inositol-1 0.0109 0.0236 0.1141
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0329 0.0781 0.3779
Echinococcus granulosus GPCR family 2 0.0125 0.0276 0.092
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.0236 0.5754
Echinococcus multilocularis lamin 0.0082 0.0168 0.0164
Brugia malayi Bromodomain containing protein 0.0033 0.0047 0.0229
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.033 0.0785 0.0781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0028 0.0081
Loa Loa (eye worm) DR-78 0.0023 0.0023 0.0112
Onchocerca volvulus 0.0097 0.0205 0.0863
Schistosoma mansoni hypothetical protein 0.0097 0.0206 0.0696
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0088 0.0285
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0088 0.0366
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.015 0.0339 0.0869
Brugia malayi beta-lactamase family protein 0.015 0.0339 0.1637
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0125 0.0276 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0088 0.0428
Mycobacterium tuberculosis Probable hydrolase 0.015 0.0339 0.0869
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0058 0.1376
Schistosoma mansoni hypothetical protein 0.027 0.0636 0.2154
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0051 0.0158
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0206 0.0998
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0088 0.0428
Brugia malayi hypothetical protein 0.0159 0.036 0.1742
Echinococcus granulosus peregrin 0.0033 0.0047 0.0146
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0023 0.0023 0.0112
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0256 0.0601 0.2905
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi Ets-domain containing protein 0.0074 0.015 0.0724
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0601 0.2033
Loa Loa (eye worm) hypothetical protein 0.0179 0.0409 0.1977
Brugia malayi Ets-domain containing protein 0.0074 0.015 0.0724
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0063 0.0198
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0058 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0088 0.0428
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0054 0.0169
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0042 0.0202
Brugia malayi hypothetical protein 0.0026 0.003 0.0146
Schistosoma mansoni alpha-glucosidase 0.0144 0.0323 0.1091
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0006 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi PHD-finger family protein 0.0024 0.0025 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0216 0.072
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0022 0.0046
Brugia malayi Fli-1 protein 0.0226 0.0526 0.2545
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0058 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0005 0.0002
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0057 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0004 0.0071
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0006 0.0015
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0058 0.018
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0097
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.0023 0.0019
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0042 0.0126
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0039 0.0063 0.0304
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0004 0.0071
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0022 0.0107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Loa Loa (eye worm) Smad1 0.0026 0.0028 0.0137
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0125 0.0276 0.0271
Brugia malayi Latrophilin receptor protein 2 0.0125 0.0276 0.1333
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.003 0.0146
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0226 0.0576
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0058 0.1376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Schistosoma mansoni zinc finger protein 0.0023 0.0023 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0088 0.0428
Echinococcus granulosus microtubule associated protein 2 0.075 0.1829 0.6192
Trichomonas vaginalis penicillin-binding protein, putative 0.015 0.0339 0.1419
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0028 0.0137
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0054 0.005
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0079 0.1907
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0054 0.005
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0057 0.0224
Echinococcus granulosus intermediate filament protein 0.0082 0.0168 0.0555
Echinococcus multilocularis nuclear receptor nhr 48 0.0023 0.0023 0.0019
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0088 0.0296
Onchocerca volvulus Alhambra homolog 0.0031 0.0042 0.0168
Echinococcus multilocularis tar DNA binding protein 0.0256 0.0601 0.0596
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0088 0.0084
Brugia malayi TAR-binding protein 0.0256 0.0601 0.2905
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.015 0.0339 0.0869
Brugia malayi hypothetical protein 0.0023 0.0023 0.0112
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0428
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0006 0.0015
Brugia malayi ecdysteroid receptor 0.005 0.0088 0.0428
Loa Loa (eye worm) MH2 domain-containing protein 0.0375 0.0897 0.434
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0381 0.0377
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0072 0.0228
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0079 0.1848
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0022 0.0505
Trichomonas vaginalis esterase, putative 0.015 0.0339 0.1419
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.0023 0.0063
Entamoeba histolytica hypothetical protein 0.033 0.0785 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0329 0.0781 0.2638
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0125 0.0276 0.092
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.015 0.0339 0.1144
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0138 0.0307 0.0303
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0007 0.0035
Brugia malayi nuclear hormone receptor 0.005 0.0088 0.0428
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0267 0.09
Echinococcus multilocularis survival motor neuron protein 1 0.0476 0.1149 0.1145
Schistosoma mansoni nuclear receptor nhr-48 0.0023 0.0023 0.0075
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.008 0.0164 0.016
Brugia malayi RNA binding protein 0.0256 0.0601 0.2905
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0058 0.2296
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0138 0.0307 0.1039
Mycobacterium tuberculosis Conserved protein 0.015 0.0339 0.0869
Loa Loa (eye worm) hypothetical protein 0.015 0.0339 0.1637
Schistosoma mansoni smad1 5 8 and 0.0026 0.0028 0.0093
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0339 0.1419
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0216 0.0212
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0226 0.0576
Brugia malayi PHD-finger family protein 0.0031 0.0042 0.0202
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1562 0.3847 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.0381 0.1842
Brugia malayi hypothetical protein 0.0115 0.0251 0.1216
Echinococcus multilocularis geminin 0.1201 0.295 0.2947
Onchocerca volvulus 0.0963 0.2358 1
Mycobacterium ulcerans hypothetical protein 0.015 0.0339 0.0869
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0057 0.1365
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0054 0.0211
Mycobacterium tuberculosis Probable lipase LipE 0.015 0.0339 0.0869
Mycobacterium ulcerans hypothetical protein 0.0023 0.0022 0.0046
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0226 0.0576
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0088 0.0285
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0023 0.0023 0.0075
Brugia malayi hypothetical protein 0.0179 0.0409 0.1977
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0004 0.0071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0057 0.0662
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.0236 0.5754
Schistosoma mansoni smad1 5 8 and 0.0026 0.0028 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0088 0.0428
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0121 0.0267 0.6481
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0088 0.0428
Onchocerca volvulus 0.0023 0.0023 0.0089
Schistosoma mansoni microtubule-associated protein tau 0.075 0.1829 0.6197
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0255 0.0651
Toxoplasma gondii LsmAD domain-containing protein 0.0179 0.0409 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0109 0.0236 0.2955
Toxoplasma gondii cathepsin CPL 0.0016 0.0006 0.0026
Brugia malayi hypothetical protein 0.033 0.0785 0.3796
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0051 0.0047
Loa Loa (eye worm) transcription factor SMAD2 0.0375 0.0897 0.434
Schistosoma mansoni inositol monophosphatase 0.0109 0.0236 0.0796
Loa Loa (eye worm) hypothetical protein 0.0068 0.0135 0.0651
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0088 0.0285
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0088 0.0084
Plasmodium vivax SET domain protein, putative 0.0121 0.0267 0.6481
Trichomonas vaginalis set domain proteins, putative 0.0963 0.2358 1
Onchocerca volvulus 0.0097 0.0206 0.0867
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0057 0.0224
Mycobacterium leprae Probable lipase LipE 0.015 0.0339 0.0827
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0057 0.0276
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0088 0.0084
Schistosoma mansoni hypothetical protein 0.0031 0.0042 0.0138
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0023 0.0023 0.0089
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0028 0.0024
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0054 0.935
Echinococcus granulosus beta LACTamase domain containing family member 0.015 0.0339 0.1134
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0087 0.2091
Trichomonas vaginalis inositol monophosphatase, putative 0.0109 0.0236 0.0983
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0088 0.0428
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.012 0.2906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0006 0.0005
Mycobacterium leprae conserved hypothetical protein 0.015 0.0339 0.0827
Brugia malayi RNA recognition motif domain containing protein 0.0256 0.0601 0.2905
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0057 0.0224
Onchocerca volvulus 0.0082 0.0168 0.0704
Onchocerca volvulus 0.015 0.0339 0.1428
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0088 0.0428
Onchocerca volvulus 0.0016 0.0006 0.0015
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0088 0.0084
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0008 0.0078
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0054 0.018
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0226 0.0532
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0014 0.007
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1562 0.3847 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0255 0.0651
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.003 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0022 0.0505
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Plasmodium falciparum glutathione reductase 0.0046 0.0079 0.1848
Schistosoma mansoni zinc finger protein 0.0019 0.0012 0.0037
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0028 0.0093
Plasmodium falciparum phd finger protein, putative 0.0031 0.0042 0.092
Brugia malayi ecdysone receptor 0.0023 0.0023 0.0112
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0022 0.0046
Mycobacterium tuberculosis Probable conserved lipoprotein 0.015 0.0339 0.0869
Brugia malayi Smad1 0.0026 0.0028 0.0137
Mycobacterium tuberculosis Probable lipase LipD 0.015 0.0339 0.0869
Schistosoma mansoni hypothetical protein 0.033 0.0785 0.2658
Loa Loa (eye worm) hypothetical protein 0.0039 0.0063 0.0303
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0006 0.0026
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.015 0.0145
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0109 0.0236 0.5754
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.033 0.0785 0.265
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0022 0.0046
Mycobacterium ulcerans transcriptional regulator 0.1562 0.3847 1
Plasmodium vivax glutathione reductase, putative 0.0046 0.0079 0.1848
Trypanosoma brucei glucosidase, putative 0.0037 0.0057 0.1365
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0006 0.0005
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0109 0.0236 0.0602
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0006 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0339 0.1419
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0846 0.2068 1
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0006 0.0097
Entamoeba histolytica hypothetical protein 0.033 0.0785 1
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0023 0.0112
Leishmania major cathepsin L-like protease 0.0016 0.0006 0.0097
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0006 0.0026
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0023 0.0075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0023 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0088 0.0428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0008 1
Echinococcus multilocularis cysteine protease 0.0016 0.0006 0.0001
Onchocerca volvulus 0.0121 0.0267 0.1122
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0057 0.1365
Echinococcus granulosus smad 0.0026 0.0028 0.0081
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0004 0.0071
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0121 0.0267 0.09
Echinococcus multilocularis smad 0.0026 0.0028 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0088 0.0428
Plasmodium vivax hypothetical protein, conserved 0.015 0.0339 0.8263
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0168 0.0812
Toxoplasma gondii thioredoxin reductase 0.0046 0.0079 0.1848
Loa Loa (eye worm) hypothetical protein 0.0053 0.0097 0.0467
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0088 0.0084
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0027
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0107
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0339 0.1419
Brugia malayi Pre-SET motif family protein 0.0121 0.0267 0.1289
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0042 0.092
Echinococcus multilocularis thyroid hormone receptor alpha 0.005 0.0088 0.0084
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0006 0.0001
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0028 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.012 0.2906
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0079 0.0383
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0112
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0054 0.0169
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0601 0.2033
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0109 0.0236 0.0983
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0004 0.0071
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0008 0.0008
Echinococcus granulosus cathepsin l1 0.0016 0.0006 0.0004
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0022 0.0213
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0088 0.0285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0006 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.027 0.0636 0.3077
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0088 0.0428
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0004 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0088 0.0428
Loa Loa (eye worm) hypothetical protein 0.0125 0.0276 0.1333
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0006 0.0016
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.0255 0.0852
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0255 0.0608
Brugia malayi Nuclear hormone receptor E75 0.0023 0.0023 0.0112
Loa Loa (eye worm) hypothetical protein 0.0026 0.003 0.0146
Mycobacterium ulcerans beta-lactamase 0.015 0.0339 0.0869
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0058 0.0279
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0329 0.0781 0.0777
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0042 0.0138
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0088 0.0366

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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