Detailed information for compound 1312690

Basic information

Technical information
  • TDR Targets ID: 1312690
  • Name: methyl 3-nitro-5-[(5-pentan-2-yl-1,3,4-thiadi azol-2-yl)carbamoyl]benzoate
  • MW: 378.403 | Formula: C16H18N4O5S
  • H donors: 1 H acceptors: 6 LogP: 3.28 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(c1nnc(s1)NC(=O)c1cc(cc(c1)C(=O)OC)[N+](=O)[O-])C
  • InChi: 1S/C16H18N4O5S/c1-4-5-9(2)14-18-19-16(26-14)17-13(21)10-6-11(15(22)25-3)8-12(7-10)20(23)24/h6-9H,4-5H2,1-3H3,(H,17,19,21)
  • InChiKey: LDYITONRRFMQLP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • methyl 3-[[5-(1-methylbutyl)-1,3,4-thiadiazol-2-yl]carbamoyl]-5-nitro-benzoate
  • 3-[[[5-(1-methylbutyl)-1,3,4-thiadiazol-2-yl]amino]-oxomethyl]-5-nitrobenzoic acid methyl ester
  • 3-[[5-(1-methylbutyl)-1,3,4-thiadiazol-2-yl]carbamoyl]-5-nitro-benzoic acid methyl ester
  • methyl 3-({[5-(1-methylbutyl)-1,3,4-thiadiazol-2-yl]amino}carbonyl)-5-nitrobenzoate
  • MLS000581908
  • SMR000200516

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma brucei hypothetical protein, conserved Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G Starlite/ChEMBL No references
Homo sapiens fatty acid synthase Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 Get druggable targets OG5_126633 All targets in OG5_126633
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Neospora caninum KR domain domain-containing protein, putative Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium parvum polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis Probable polyketide synthase Pks7 Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable polyketide synthase Pks5 Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium leprae Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Probable polyketide synthase Pks8 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 Get druggable targets OG5_126633 All targets in OG5_126633
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania major hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) acyl carrier protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks12 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii AMP-binding enzyme domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_146801 All targets in OG5_146801
Leishmania donovani HpcH/HpaI aldolase/citrate lyase family, putative Get druggable targets OG5_146801 All targets in OG5_146801
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Fatty acid synthase homolog Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Soraphen polyketide synthase A, related Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 Get druggable targets OG5_126633 All targets in OG5_126633
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium ulcerans polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Polyketide synthase Pks2 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium leprae Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium tuberculosis Probable polyketide synthase Pks15 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.1026 0.1017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0517 0.7924 0.7856
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.3258 0.3036
Loa Loa (eye worm) hypothetical protein 0.0081 0.112 0.1112
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0218 0.3258 0.3251
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0042 0.051 0.0105
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.1906 0.1641
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0123 0.1774 0.1767
Loa Loa (eye worm) hypothetical protein 0.0051 0.0645 0.0636
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0042 0.051 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0042 0.051 1
Brugia malayi ecdysteroid receptor 0.0012 0.0046 0.0046
Schistosoma mansoni kinase 0.0058 0.0761 0.0753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.051 0.0199
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0042 0.051 0.0199
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.041 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0517 0.7933 0.7869
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.041 0.0116
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0042 0.051 0.022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0123 0.1774 0.1774
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.051 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0649 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0042 0.051 0.0502
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.051 0.051
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0046 0.0037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0046 0.0037
Leishmania major phosphatidylinositol kinase, putative 0.0042 0.051 0.022
Mycobacterium ulcerans polyketide synthase 0.003 0.0325 0.1276
Schistosoma mansoni hypothetical protein 0.0042 0.051 0.0502
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.1906 0.1641
Echinococcus multilocularis serine protein kinase ATM 0.0123 0.1774 0.1767
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0649 1 1
Mycobacterium ulcerans polyketide synthase 0.0032 0.0354 0.139
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0297 0.1164
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0046 0.0037
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0046 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0046 0.0037
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0123 0.1774 0.1523
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5369 0.5217
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.041 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0436 0.666 0.6551
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0042 0.051 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0517 0.7924 0.7856
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0011 0.0002
Trypanosoma brucei polo-like protein kinase 0.0114 0.1638 0.1382
Brugia malayi MH2 domain containing protein 0.001 0.0009 0.0009
Onchocerca volvulus 0.0287 0.4336 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0042 0.051 0.0199
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5369 0.5217
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0024 0.0233 0.0916
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5369 0.5217
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.1906 0.1899
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0042 0.051 0.0502
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0123 0.1774 0.1774
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0042 0.051 0.0502
Schistosoma mansoni coup transcription factor 0.0012 0.0046 0.0037
Mycobacterium ulcerans polyketide synthase Pks13 0.0045 0.0558 0.2187
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1638 0.1382
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0297 0.1153
Brugia malayi Pre-SET motif family protein 0.0037 0.0431 0.0431
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0042 0.051 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.035 0.5325 0.5171
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0046 0.0046
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0046 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0483 0.7401 0.7315
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0042 0.051 0.0199
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.1424 0.1416
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.051 0.022
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0042 0.051 0.0199
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1638 0.1363
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0042 0.051 0.0199
Loa Loa (eye worm) phosphatidylinositol 3 0.0649 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0046 0.0046
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0042 0.051 0.0502
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.1906 0.7478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.5333 0.518
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0037
Mycobacterium ulcerans hypothetical protein 0.003 0.0318 0.1247
Brugia malayi steroid hormone receptor 0.0012 0.0046 0.0046
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0017 0.0123 0.0481
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0042 0.051 0.0502
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.002 0.0166 0.064
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.041 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0649 1 1
Mycobacterium ulcerans thioesterase TesA 0.0025 0.0247 0.0969
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0046 0.0037
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0042 0.051 0.0199
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0032 0.0354 0.139
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0046 0.0037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0037
Brugia malayi 6-phosphofructokinase 0.0131 0.1906 0.1906
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.051 0.051
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.051 0.051
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.019 0.0133
Trypanosoma cruzi target of rapamycin kinase 3 0.0517 0.7933 0.7865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0123 0.1774 0.1504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5369 0.5217
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0649 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0123 0.1774 0.1504
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1638 0.1363
Loa Loa (eye worm) hypothetical protein 0.0123 0.1774 0.1767
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0046 0.0037
Brugia malayi CXXC zinc finger family protein 0.0035 0.0397 0.0397
Loa Loa (eye worm) phosphatidylinositol 3 0.0218 0.3258 0.3251
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1638 0.1363
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0095 0.1339 0.1331
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5369 0.5217
Entamoeba histolytica hypothetical protein 0.0123 0.1774 0.1523
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0042 0.051 0.0502
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0057 0.0746 0.0746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.3258 0.3036
Echinococcus multilocularis 0.0042 0.051 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.5333 0.518
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0042 0.051 0.0502
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0318 0.0309
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0046 0.0037
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.1906 0.1641
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0042 0.051 0.022
Brugia malayi phosphofructokinase 0.0131 0.1906 0.1906
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.3258 0.3036
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0044 0.0035
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0123 0.1774 0.1767
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.1906 0.1659
Schistosoma mansoni cpg binding protein 0.0035 0.0397 0.0389
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0431 0.0422
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0218 0.3258 0.3258
Toxoplasma gondii target of rapamycin (TOR), putative 0.0483 0.7401 1
Plasmodium vivax hypothetical protein 0.0042 0.051 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.5333 0.518
Leishmania major phosphatidylinositol 3-kinase, putative 0.0218 0.3258 0.3051
Echinococcus multilocularis cpg binding protein 0.0037 0.0428 0.042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1001 0.3927
Plasmodium vivax hypothetical protein, conserved 0.0042 0.051 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0384 0.5857 0.5721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0517 0.7924 0.7856
Entamoeba histolytica hypothetical protein 0.0042 0.051 0.022
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1001 0.0993
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0046 0.0037
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.5369 0.5172
Loa Loa (eye worm) hypothetical protein 0.0042 0.051 0.0502
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.112 0.0828
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0046 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.041 0.0095
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.2549 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.002 0.0166 0.0652
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0318 0.1247
Brugia malayi Pre-SET motif family protein 0.0252 0.3794 0.3794
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0294 0.1155
Brugia malayi 6-phosphofructokinase 0.0131 0.1906 0.1906
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0046 0.0046
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.051 0.0199
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0029 0.0311 0.1219
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0325 0.1276
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.051 0.051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0037
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0042 0.051 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1638 0.1382
Onchocerca volvulus 0.01 0.1424 0.3212
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.051 0.0502
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0046 0.0046
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0046 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0046 0.0046
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0397 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.051 0.0199
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0042 0.051 0.0199
Leishmania major phosphatidylinositol kinase related protein, putative 0.0042 0.051 0.022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0483 0.7401 0.7315
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1001 0.0993
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0045 0.0558 0.2187
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.051 0.2001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0483 0.7401 0.7315
Schistosoma mansoni hypothetical protein 0.0494 0.7572 0.757
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1638 0.1363
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0044 0.0035
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0046 0.0037
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0318 0.0022
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1001 0.0993
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0042 0.051 0.0502
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0046 0.0037
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.041 0.5289
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1638 0.1363
Echinococcus granulosus serine protein kinase ATM 0.0123 0.1774 0.1767
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.001 0.0017 0.0067
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.051 0.051
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0042 0.051 0.0199
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.1906 0.1659
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.051 0.051
Brugia malayi nuclear hormone receptor 0.0012 0.0046 0.0046
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.1906 0.1899
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0042 0.051 0.022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0037
Onchocerca volvulus 0.0052 0.0673 0.1461
Echinococcus granulosus cpg binding protein 0.0037 0.0428 0.042
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.3869 0.3668
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0325 0.1276
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0649 1 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0042 0.051 0.022
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0025 0.024 0.094
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0297 0.1164
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.3794 0.3788
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1001 0.0726
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.1906 0.1899
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0095 0.1339 0.1331
Onchocerca volvulus 0.0182 0.2706 0.6201
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1001 0.3927
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0046 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.3869 0.3668
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.051 0.0571
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0042 0.051 1
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0318 0.1247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0649 1 1
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0032 0.0354 0.138
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0042 0.051 0.0199
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0046 0.0037
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.041 0.0433
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0046 0.0037
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0046 0.0037
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0738 0.0434
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0046 0.0037
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0318 0.0309
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0032 0.0354 0.139
Entamoeba histolytica hypothetical protein 0.0042 0.051 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0483 0.7401 0.7315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0483 0.7401 0.7315
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0045 0.0558 0.2187
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.0325 0.1276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0174 0.2577 0.2334
Mycobacterium leprae Polyketide synthase Pks13 0.0045 0.0558 0.2178
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0042 0.051 0.051
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0046 0.0046
Onchocerca volvulus 0.0042 0.051 0.1081
Loa Loa (eye worm) phosphatidylinositol kinase 0.0042 0.051 0.0502
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.1906 0.1899
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.1906 0.1641
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0046 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0046 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0046 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.112 0.0828
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0649 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0042 0.051 0.0502
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0042 0.051 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0483 0.7401 0.7315
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.051 0.0571
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.041 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0384 0.5857 0.5721
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.1906 0.1899
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0218 0.3258 0.3251
Giardia lamblia Hypothetical protein 0.0042 0.051 0.0105
Loa Loa (eye worm) hypothetical protein 0.0132 0.1923 0.1916
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.1906 0.1899
Leishmania major hypothetical protein, unknown function 0.0042 0.051 0.022
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.5369 0.5228
Loa Loa (eye worm) hypothetical protein 0.0095 0.1339 0.1331
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.051 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0388 0.5917 0.5783
Toxoplasma gondii FATC domain-containing protein 0.0123 0.1774 0.2301
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.003 0.0325 0.0325
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.1906 0.7475
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.051 0.0199
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0398 0.0389
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0029 0.0311 0.1219
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2108 0.2101
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1638 0.1363
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.2549 1
Loa Loa (eye worm) fatty acid synthase 0.003 0.0319 0.031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0422 0.6441 0.6324
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0011 0.0002
Leishmania major hypothetical protein, conserved 0.0257 0.3869 0.3681
Mycobacterium tuberculosis Conserved protein 0.003 0.0318 0.1247
Onchocerca volvulus 0.0037 0.0431 0.0896
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0032 0.0354 0.139
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0042 0.051 1
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1638 0.163
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.1906 0.1641
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0042 0.051 0.0199
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0042 0.051 0.022
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0037
Echinococcus multilocularis Zinc finger, PHD finger 0.0042 0.051 0.0502
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.051 0.0502
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0218 0.3258 0.3051
Loa Loa (eye worm) hypothetical protein 0.0042 0.051 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.035 0.5325 0.5171
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5369 0.5217
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0042 0.051 0.0105
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0022 0.0193 0.0757
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0218 0.3258 0.3051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0431 0.0422
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5369 0.5217
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1001 0.3927
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0011 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.3258 0.3036
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.051 0.0502
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0046 0.0046
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0325 0.1276
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0649 1 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0042 0.051 0.0502
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0294 0.0286
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.2549 1
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0318 0.1247
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0081 0.112 0.0828
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0042 0.051 0.0502
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0431 0.0422
Entamoeba histolytica hypothetical protein 0.0042 0.051 0.022
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0046 0.0037
Leishmania major hypothetical protein, conserved 0.0042 0.051 0.022
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.002 0.016 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0388 0.5917 0.5783
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.003 0.0325 0.1265
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0042 0.051 0.0199
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.027 0.4069 0.3888
Loa Loa (eye worm) phosphofructokinase 0.0131 0.1906 0.1899
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0042 0.051 0.0502
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0042 0.051 0.0199
Brugia malayi MH2 domain containing protein 0.0144 0.2108 0.2108
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.1906 0.7478
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.3869 0.3681
Mycobacterium ulcerans fatty acid synthase Fas 0.0009 0.0003 0.0012
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.051 0.0502
Brugia malayi Smad1 0.001 0.0009 0.0009
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0042 0.051 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0218 0.3258 0.3036
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0046 0.0037
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0042 0.051 0.0502
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0325 0.1276
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0012 0.0046 0.0179
Schistosoma mansoni cpg binding protein 0.0037 0.0428 0.042
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0297 0.1164
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0123 0.1774 0.1767
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.051 0.0571
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0042 0.0042
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0325 0.1276
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0354 0.139
Giardia lamblia Kinase, PLK 0.0114 0.1638 0.128
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1638 0.371
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1001 0.1243
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0042 0.051 0.0199
Toxoplasma gondii type I fatty acid synthase, putative 0.0032 0.0354 0.0358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.8517 0.8468
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0011 0.0002
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0233 0.0916
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0123 0.1774 0.1523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0351 0.5333 0.518
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0123 0.1774 0.1504
Giardia lamblia GTOR 0.0649 1 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0024 0.0233 0.0905
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0046 0.0046
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0431 0.0422
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.1424 0.1416
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.1906 0.3173
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1638 0.1363
Loa Loa (eye worm) acyl carrier protein 0.0014 0.0072 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0388 0.5917 0.5783
Echinococcus granulosus dnaJ subfamily B 0.0494 0.7572 0.757
Trichomonas vaginalis conserved hypothetical protein 0.0137 0.1993 0.1731
Onchocerca volvulus 0.0042 0.051 0.1081
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0218 0.3258 0.3051
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0025 0.0247 0.0958
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0042 0.051 0.0502
Loa Loa (eye worm) hypothetical protein 0.0182 0.2706 0.27
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0517 0.7933 0.7869
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.003 0.0325 0.1265
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1638 0.1638
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.041 0.5289
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.041 0.0433
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.1906 0.1659
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.041 0.0222
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0046 0.0037
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.051 0.0199
Onchocerca volvulus Fatty acid synthase homolog 0.0054 0.0702 0.1529
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.051 0.022
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0046 0.0037
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0042 0.051 0.022
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0297 0.0279
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0294 0.0294
Brugia malayi nuclear receptor NHR-88 0.0012 0.0046 0.0046
Schistosoma mansoni cpg binding protein 0.0037 0.0428 0.042
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0046 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0046 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0431 0.0422
Entamoeba histolytica hypothetical protein 0.0042 0.051 0.022
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1638 0.1363
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.051 0.0571
Brugia malayi MH2 domain containing protein 0.001 0.0009 0.0009
Onchocerca volvulus 0.0028 0.0294 0.0578
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0903 0.1108
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0218 0.3258 0.3036
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0738 0.0434
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0037
Trichomonas vaginalis set domain proteins, putative 0.0287 0.4336 0.415
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0042 0.051 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1001 0.3927
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0032 0.0354 0.138
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.041 0.0095
Leishmania major phosphatidylinositol 3-kinase, putative 0.0042 0.051 0.022
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0137 0.1993 0.2601
Mycobacterium tuberculosis Probable thioesterase TesA 0.0025 0.0247 0.0969
Loa Loa (eye worm) hypothetical protein 0.01 0.1424 0.1416
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0042 0.051 0.0502
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0046 0.0037
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0649 1 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0042 0.051 0.022
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1638 0.163
Trichomonas vaginalis PIKK family atypical protein kinase 0.035 0.5325 0.5171
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0009 0.0003 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.1339 0.1055
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.5369 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0042 0.051 0.0199
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1638 0.163
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0649 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0046 0.0037
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0042 0.051 0.0502
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0046 0.0046
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0123 0.1774 0.1504
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0297 0.0279
Trichomonas vaginalis PIKK family atypical protein kinase 0.0123 0.1774 0.1504
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0649 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0307 0.4653 0.449
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0042 0.051 0.0502
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0042 0.051 0.0199
Loa Loa (eye worm) hypothetical protein 0.0137 0.1993 0.1986
Onchocerca volvulus 0.0035 0.0397 0.0819
Mycobacterium ulcerans polyketide synthase Pks9 0.002 0.0166 0.0652
Loa Loa (eye worm) hypothetical protein 0.0017 0.0119 0.011
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0046 0.0037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0037
Plasmodium vivax SET domain protein, putative 0.0037 0.0431 0.6273
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.1424 0.1416
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0042 0.051 0.022
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0046 0.0037
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0042 0.051 0.0502
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0318 0.1247
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.051 0.0502
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.041 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0431 0.0422
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.5369 0.5228
Mycobacterium ulcerans hypothetical protein 0.003 0.0318 0.1247
Brugia malayi MH1 domain containing protein 0.001 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0483 0.7401 0.7315
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1638 0.1363
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5369 0.5217
Schistosoma mansoni fkbp-rapamycin associated protein 0.0123 0.1774 0.1767
Brugia malayi hypothetical protein 0.0182 0.2706 0.2706
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.051 0.0571
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0046 0.0037
Entamoeba histolytica protein kinase rad3, putative 0.0123 0.1774 0.1523
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.1424 0.1424
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0649 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0431 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0046 0.0046
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0046 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.041 0.0095
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0218 0.3258 0.3251
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2108 0.2101
Schistosoma mansoni hypothetical protein 0.0095 0.1339 0.1331
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.041 0.5289
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0046 0.0037
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0044 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0517 0.7924 0.7856
Mycobacterium ulcerans thioesterase 0.0025 0.0247 0.0969
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.051 0.022
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0042 0.051 0.0199
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0431 0.0462
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.003 0.0325 0.1276
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0046 0.0037
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0011 0.0002
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0042 0.051 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0431 0.0422
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0649 1 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0354 0.139
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.041 0.0433
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.051 0.0199
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0649 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0042 0.051 0.0502
Brugia malayi MH1 domain containing protein 0.001 0.0009 0.0009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0046 0.0037
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.041 0.5289
Loa Loa (eye worm) hypothetical protein 0.0012 0.0046 0.0037
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.1906 0.1659
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.1906 0.1659
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1638 0.163
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0046 0.0037
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0042 0.051 0.0199
Brugia malayi FAT domain containing protein 0.0095 0.1339 0.1339
Mycobacterium leprae Probable polyketide synthase Pks1 0.0032 0.0354 0.138
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0042 0.051 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0046 0.0046
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.7572 0.757
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0297 0.5
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0218 0.3258 0.3036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0046 0.0046
Mycobacterium leprae conserved hypothetical protein 0.0042 0.051 0.1991
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.041 0.0095
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0046 0.0046
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0042 0.051 0.022
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1001 0.0993
Trichomonas vaginalis PIKK family atypical protein kinase 0.0517 0.7924 0.7856
Giardia lamblia Phosphatidylinositol 4-kinase 0.0042 0.051 0.0105

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 7.04 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 7.12 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 19.6 uM PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493012, AID493028] ChEMBL. No reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.9728 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.7456 uM PUBCHEM_BIOASSAY: Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.1014 uM PUBCHEM_BIOASSAY: Inhibitors of T. brucei phosphofructokinase: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7407 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Giardia lamblia growth inhibition. (Class of assay: confirmatory) [Related pubchem assays: 2451, 2472, 2464 ] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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