Detailed information for compound 1312796

Basic information

Technical information
  • TDR Targets ID: 1312796
  • Name: N-[1,1,1,3,3,3-hexafluoro-2-[(6-nitro-1,3-ben zothiazol-2-yl)amino]propan-2-yl]pyridine-3-c arboxamide
  • MW: 465.33 | Formula: C16H9F6N5O3S
  • H donors: 2 H acceptors: 5 LogP: 5.19 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccnc1)NC(C(F)(F)F)(C(F)(F)F)Nc1nc2c(s1)cc(cc2)[N+](=O)[O-]
  • InChi: 1S/C16H9F6N5O3S/c17-15(18,19)14(16(20,21)22,25-12(28)8-2-1-5-23-7-8)26-13-24-10-4-3-9(27(29)30)6-11(10)31-13/h1-7H,(H,24,26)(H,25,28)
  • InChiKey: SFAODBVTGWNNCF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[2,2,2-trifluoro-1-[(6-nitro-1,3-benzothiazol-2-yl)amino]-1-(trifluoromethyl)ethyl]pyridine-3-carboxamide
  • N-[2,2,2-trifluoro-1-[(6-nitro-1,3-benzothiazol-2-yl)amino]-1-(trifluoromethyl)ethyl]-3-pyridinecarboxamide
  • N-[2,2,2-trifluoro-1-[(6-nitro-1,3-benzothiazol-2-yl)amino]-1-(trifluoromethyl)ethyl]nicotinamide
  • ZINC00721311
  • STOCK3S-67955
  • MLS000591280
  • N-[2,2,2-Trifluoro-1-(6-nitro-benzothiazol-2-ylamino)-1-trifluoromethyl-ethyl]-nicotinamide
  • SMR000218920
  • AG-389/15452453

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens nuclear receptor subfamily 2, group F, member 1 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens galanin receptor 3 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens paired box 8 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) nuclear hormone receptor Get druggable targets OG5_131829 All targets in OG5_131829
Onchocerca volvulus Get druggable targets OG5_139945 All targets in OG5_139945
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131829 All targets in OG5_131829
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor Get druggable targets OG5_131829 All targets in OG5_131829
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor Get druggable targets OG5_131829 All targets in OG5_131829
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Steroid receptor seven-up type 2 Get druggable targets OG5_131829 All targets in OG5_131829
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Brugia malayi ecdysteroid receptor nuclear receptor subfamily 2, group F, member 1 423 aa 354 aa 26.3 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0258
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0019 0.0051
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0139 0.5676
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0005 0.0014
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0189 0.7707
Loa Loa (eye worm) hypothetical protein 0.0103 0.0357 0.1095
Loa Loa (eye worm) TAR-binding protein 0.0256 0.0974 0.2988
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.1067 0.1067
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0084 0.0084
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0148 0.0455
Brugia malayi MH2 domain containing protein 0.0025 0.004 0.0121
Schistosoma mansoni lamin 0.0105 0.0365 0.1384
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0091 0.0091
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0035 0.0038
Echinococcus granulosus intermediate filament protein 0.0105 0.0365 0.1342
Loa Loa (eye worm) hypothetical protein 0.0064 0.0199 0.061
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0148 0.0455
Brugia malayi Muscleblind-like protein 0.018 0.0668 0.2048
Onchocerca volvulus 0.002 0.0019 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0226 0.9203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0189 0.7707
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0019 0.0058
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0153
Schistosoma mansoni survival motor neuron protein 0.0099 0.0339 0.1286
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0005 0.0005
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0215 0.0659
Entamoeba histolytica hypothetical protein 0.018 0.0666 1
Giardia lamblia Thymus-specific serine protease precursor 0.002 0.0019 0.08
Brugia malayi Doublecortin family protein 0.0019 0.0017 0.0052
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0105 0.0365 0.1119
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0117
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0089 0.0123
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0215 0.0809 0.2481
Brugia malayi Inositol-1 0.0037 0.0089 0.0272
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0366 0.1416 0.1416
Toxoplasma gondii cathepsin CPL 0.0016 0.0005 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Brugia malayi isocitrate dehydrogenase 0.0019 0.0017 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0189 0.7707
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0226 0.0358
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0226 0.0341
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0084 0.3533
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0117
Echinococcus multilocularis musashi 0.0105 0.0365 0.0365
Onchocerca volvulus 0.0024 0.0035 0.0095
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0043 0.0132
Loa Loa (eye worm) hypothetical protein 0.0071 0.0226 0.0692
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0035 0.1442
Brugia malayi latrophilin 2 splice variant baaae 0.0147 0.0534 0.1638
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0453 0.1766 0.2803
Onchocerca volvulus 0.0024 0.0038 0.0103
Echinococcus multilocularis GPCR, family 2 0.0068 0.0215 0.0215
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0017 0.0682
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0455
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0038 0.0117
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0035 0.1442
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.1067 0.3927
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0148 0.0563
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0005 0.0014
Leishmania major cathepsin L-like protease 0.0016 0.0005 0.021
Giardia lamblia Serine peptidase, putative 0.002 0.0019 0.08
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0148 0.0455
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0139 0.0139
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0074 0.0238 0.5728
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0005 0.0014
Schistosoma mansoni hypothetical protein 0.0099 0.0339 0.1286
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0148 0.0148
Echinococcus granulosus GPCR family 2 0.0068 0.0215 0.079
Entamoeba histolytica Ran family GTPase 0.0026 0.0043 0.0648
Loa Loa (eye worm) inositol-1 0.0037 0.0089 0.0272
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0038 0.014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0005 0.0014
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0226 0.0226
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0148 0.0455
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0051 0.0145 0.0533
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0148 0.0546
Schistosoma mansoni rab6-interacting 0.0019 0.0017 0.0064
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0091 0.0245
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0455
Echinococcus granulosus expressed conserved protein 0.0112 0.039 0.1436
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0148 0.0455
Echinococcus multilocularis tumor protein p63 0.0688 0.2718 0.2718
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0034
Brugia malayi hypothetical protein 0.0024 0.0038 0.0117
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.004 0.0146
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0139 0.5676
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0346 0.1314
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0004 0.0159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0189 0.7707
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.002 0.0019 0.0778
Echinococcus granulosus cathepsin l1 0.0016 0.0005 0.0019
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0089 0.0089
Schistosoma mansoni zinc finger protein 0.0024 0.0038 0.0145
Loa Loa (eye worm) hypothetical protein 0.0158 0.0575 0.1765
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0011 0.0456
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0058
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0089 0.0239
Loa Loa (eye worm) hypothetical protein 0.0049 0.0137 0.042
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0139 0.5676
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0148 0.0546
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0017 0.0682
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0148 0.0455
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.002 0.0019 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0139 0.0528
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0005 0.021
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0019 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0005 0.0014
Loa Loa (eye worm) transcription factor SMAD2 0.0363 0.1406 0.4312
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0052
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0038 0.0117
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0245 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0035 0.0531
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0056 0.0167 0.0635
Brugia malayi nuclear receptor RXR 0.0024 0.0038 0.0117
Onchocerca volvulus 0.0101 0.0346 0.0931
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0091 0.2187
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.0131 0.0401
Schistosoma mansoni lipoxygenase 0.0019 0.0017 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.0416 0.1578
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0058
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0091 0.0245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0148 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.016 0.0586 0.2157
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0074 0.0238 0.9718
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0038 0.014
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0148 0.0455
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0038 0.014
Schistosoma mansoni coup transcription factor 0.0052 0.0148 0.0563
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0038 0.0038
Toxoplasma gondii exonuclease III APE 0.0074 0.0238 0.5728
Schistosoma mansoni hypothetical protein 0.0049 0.0138 0.0524
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.042 0.1287
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0189 0.7707
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0074 0.0238 0.0361
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.008 0.3273
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0017 0.0062
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0005 0.0019
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0245 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0076 0.0245 0.0752
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0089 0.1333
Brugia malayi MH2 domain containing protein 0.0363 0.1406 0.4312
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0019 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0148 0.0455
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0038 0.014
Onchocerca volvulus 0.0071 0.0226 0.0607
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0148 0.0399
Brugia malayi beta-lactamase family protein 0.0071 0.0226 0.0692
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0091 0.0245
Schistosoma mansoni lipoxygenase 0.0054 0.0156 0.0591
Brugia malayi ecdysteroid receptor 0.0052 0.0148 0.0455
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0017 0.0402
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0038 0.0117
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0005 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0153
Loa Loa (eye worm) DR-78 0.0024 0.0038 0.0117
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0091 0.0245
Schistosoma mansoni hypothetical protein 0.0068 0.0215 0.0815
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0148 0.0563
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0091 0.0245
Echinococcus granulosus importin subunit beta 1 0.0035 0.008 0.0295
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0139 0.5676
Loa Loa (eye worm) hypothetical protein 0.0071 0.0226 0.0692
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0226 0.0692
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0148 0.0148
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0245 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0089 0.3619
Brugia malayi Cathepsin L-like precursor 0.0016 0.0005 0.0016
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0084 0.1264
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0074 0.0238 0.0877
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0215 0.0215
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0091 0.0279
Brugia malayi hypothetical protein 0.0158 0.0575 0.1765
Brugia malayi Pax transcription factor protein 2 0.0291 0.1113 0.3413
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.0119 0.042 0.1287
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0226 0.0358
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0118 0.0416 0.1578
Leishmania major cathepsin L-like protease 0.0016 0.0005 0.021
Echinococcus multilocularis importin subunit beta 1 0.0035 0.008 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0189 0.7707
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0019 0.0286
Echinococcus multilocularis cysteine protease 0.0016 0.0005 0.0005
Onchocerca volvulus 0.0118 0.0416 0.1119
Brugia malayi MAP kinase sur-1 0.0049 0.0139 0.0427
Schistosoma mansoni hypothetical protein 0.0334 0.1288 0.4887
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0974 0.3696
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0017 0.0682
Brugia malayi hypothetical protein 0.018 0.0666 0.2043
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0017 0.0051
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0148 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0084 0.0226
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0974 0.3696
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0226 0.0358
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0108
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0625 0.0625
Brugia malayi nuclear hormone receptor 0.0052 0.0148 0.0455
Loa Loa (eye worm) hypothetical protein 0.0035 0.008 0.0246
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0056 0.0167 0.6822
Brugia malayi prolyl oligopeptidase family protein 0.0056 0.0167 0.0513
Loa Loa (eye worm) hypothetical protein 0.0071 0.0226 0.0692
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0017 0.0402
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0139 0.0427
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0139 0.3345
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0139 0.0512
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0019 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0139 0.0374
Schistosoma mansoni hypothetical protein 0.0019 0.0017 0.0064
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0004 0.0159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0019 0.0051
Brugia malayi Ets-domain containing protein 0.0075 0.0243 0.0744
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.016 0.0586 0.0586
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0091 0.0245
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.005 0.005
Brugia malayi beta-lactamase 0.0071 0.0226 0.0692
Echinococcus granulosus smad 0.0025 0.004 0.0146
Loa Loa (eye worm) hypothetical protein 0.0043 0.0114 0.0349
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0084 0.031
Brugia malayi follicle stimulating hormone receptor 0.0452 0.1763 0.5406
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.005 0.0184
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0051 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0051 0.0145 0.0444
Brugia malayi nuclear receptor NHR-67 0.0024 0.0038 0.0117
Onchocerca volvulus 0.0019 0.0017 0.0045
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0148 0.0455
Schistosoma mansoni ap endonuclease 0.0074 0.0238 0.0904
Trichomonas vaginalis ap endonuclease, putative 0.0074 0.0238 0.0641
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0035 0.0038
Schistosoma mansoni hypothetical protein 0.0049 0.0138 0.0524
Brugia malayi Cathepsin L-like precursor 0.0016 0.0005 0.0016
Onchocerca volvulus 0.0016 0.0005 0.0014
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0084 0.031
Brugia malayi beta-lactamase family protein 0.0071 0.0226 0.0692
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0073 0.006
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.008 0.1929
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Schistosoma mansoni smad1 5 8 and 0.0025 0.004 0.015
Schistosoma mansoni gabp alpha 0.0075 0.0243 0.0921
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0043 0.176
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0148 0.0563
Schistosoma mansoni importin beta-1 0.0035 0.008 0.0305
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0452 0.1763 0.5406
Brugia malayi Ets-domain containing protein 0.0075 0.0243 0.0744
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0091 0.0335
Trichomonas vaginalis ap endonuclease, putative 0.0074 0.0238 0.0641
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0017 0.0017
Mycobacterium tuberculosis Conserved protein 0.0071 0.0226 0.0358
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0038 0.0145
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0148 0.0546
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0226 0.0692
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0226 0.0358
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0005 0.0077
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0168 0.0617 0.2339
Onchocerca volvulus 0.0071 0.0226 0.0607
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0084 0.0084
Echinococcus granulosus lamin dm0 0.0105 0.0365 0.1342
Schistosoma mansoni transcription factor LCR-F1 0.018 0.0666 0.2527
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0148 0.0537 0.1646
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0056 0.0167 0.4021
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.002 0.0019 0.0778
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0019 0.0051
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0455
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0074 0.0238 0.9718
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0455
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0077 0.0282
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0038 0.0145
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0043 0.0159
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.005 0.0153
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0156 0.0573
Brugia malayi Intermediate filament tail domain containing protein 0.0105 0.0365 0.1119
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0091 0.0279
Leishmania major cathepsin L-like protease 0.0062 0.0189 0.7707
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0005 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.1067 0.3927
Toxoplasma gondii serine carboxypeptidase s28 protein 0.002 0.0019 0.0458
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.004 0.015
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0169 0.0621 0.1906
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0455
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0226 0.9203
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0035 0.0108
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0035 0.0038
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0005 0.0014
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0139 0.5676
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.004 0.004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0118 0.0416 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0074 0.0238 0.9718
Plasmodium vivax SET domain protein, putative 0.0118 0.0416 1
Schistosoma mansoni hypothetical protein 0.0049 0.0138 0.0524
Echinococcus multilocularis tar DNA binding protein 0.0256 0.0974 0.0974
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0035 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0226 0.0607
Onchocerca volvulus 0.0099 0.0339 0.0911
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0038 0.0145
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0226 0.5424
Mycobacterium tuberculosis Conserved protein 0.0071 0.0226 0.0358
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0215 0.079
Brugia malayi intermediate filament protein 0.0105 0.0365 0.1119
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0058
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0011 0.0018
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0054 0.0144
Brugia malayi hypothetical protein 0.0148 0.0537 0.1646
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0114 0.0398 0.1466
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0215 0.0215
Leishmania major GTP-binding protein, putative 0.0026 0.0043 0.176
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0215 0.0809 0.2481
Echinococcus granulosus tumor protein p63 0.0688 0.2718 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0091 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0148 0.0455
Onchocerca volvulus 0.0105 0.0365 0.0981
Brugia malayi hypothetical protein 0.0027 0.005 0.0153
Onchocerca volvulus 0.0016 0.0005 0.0014
Schistosoma mansoni ran 0.0026 0.0043 0.0164
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0117
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0005 0.021
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0084 0.3434
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Trypanosoma brucei protein kinase, putative 0.0049 0.0139 0.5676
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0084 0.0258
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0084 0.3434
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0148 0.0455
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0084 0.0084
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0139 0.0374
Brugia malayi Steroid receptor seven-up type 2 0.016 0.0586 0.1798
Onchocerca volvulus 0.0071 0.0226 0.0607
Schistosoma mansoni rab6-interacting 0.0019 0.0017 0.0064
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0226 0.0856
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0148 0.0563
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0148 0.0546
Brugia malayi Cathepsin L-like precursor 0.0016 0.0005 0.0016
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0038 0.0103
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0136 0.5531
Loa Loa (eye worm) prolyl oligopeptidase 0.0168 0.0617 0.1891
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0091 0.0245
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0168 0.0617 0.2268
Echinococcus multilocularis Smad4 0.0025 0.004 0.004
Plasmodium falciparum importin beta, putative 0.0035 0.008 0.3273
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0035 0.0531
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.005 0.019
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0084 0.3434
Brugia malayi tailless protein 0.0024 0.0038 0.0117
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0117
Onchocerca volvulus 0.0016 0.0005 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0189 0.7707
Mycobacterium ulcerans beta-lactamase 0.0071 0.0226 0.0341
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1577 0.6302 1
Echinococcus granulosus geminin 0.0334 0.1288 0.4739
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0974 0.3696
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0189 0.7707
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0189 0.7707
Onchocerca volvulus 0.0291 0.1113 0.2992
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0256 0.0974 0.2988
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0226 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0148 0.0455
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0148 0.0148
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0054 0.0144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0117
Loa Loa (eye worm) hypothetical protein 0.0105 0.0365 0.1119
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0034
Loa Loa (eye worm) hypothetical protein 0.0148 0.0537 0.1646
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.042 0.6299
Schistosoma mansoni polycystin 1-related 0.0019 0.0017 0.0064
Schistosoma mansoni nuclear receptor 0.0024 0.0038 0.0145
Plasmodium vivax vivapain-2 0.0016 0.0005 0.0124
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0146 0.0447
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0017 0.0682
Brugia malayi RNA binding protein 0.0256 0.0974 0.2988
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0974 0.3696
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0074 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0052
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0245 0.5894
Loa Loa (eye worm) fli-1 protein 0.0228 0.0859 0.2636
Onchocerca volvulus 0.0019 0.0015 0.0039
Entamoeba histolytica hypothetical protein 0.0028 0.0054 0.0806
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0017
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0035 0.0038
Echinococcus multilocularis expressed conserved protein 0.0112 0.039 0.039
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0017 0.0062
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0089 0.3619
Loa Loa (eye worm) Smad1 0.0025 0.004 0.0121
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0074 0.0238 0.0378
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0226 0.0358
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0117
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0017 0.0017
Brugia malayi hypothetical protein 0.0019 0.0017 0.0052
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0056 0.0167 0.6822
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.005 0.0153
Loa Loa (eye worm) hypothetical protein 0.018 0.0668 0.2048
Brugia malayi MH1 domain containing protein 0.0025 0.004 0.0121
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0243 0.0893
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0056 0.0167 0.6822
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0038 0.0145
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0035 0.0108
Schistosoma mansoni loxhd1 0.0019 0.0017 0.0064
Echinococcus multilocularis RUN 0.0019 0.0017 0.0017
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0148 0.0148
Trichomonas vaginalis set domain proteins, putative 0.0936 0.3719 1
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0148 0.0399
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0108
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0226 0.9203
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0168 0.0617 0.0617
Brugia malayi nuclear hormone receptor 0.0024 0.0038 0.0117
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.004 0.0146
Brugia malayi hypothetical protein 0.0043 0.0114 0.0349
Echinococcus multilocularis cysteine protease 0.0016 0.0005 0.0005
Plasmodium vivax importin-beta 2, putative 0.0035 0.008 0.1929
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0017 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0091 0.371
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0117
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.002 0.0019 0.007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0005 0.0016
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0005 0.0016
Brugia malayi TAR-binding protein 0.0256 0.0974 0.2988
Brugia malayi Cathepsin L-like precursor 0.0016 0.0005 0.0016
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0005 0.0019
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0146 0.0536
Schistosoma mansoni hypothetical protein 0.0068 0.0215 0.0815
Mycobacterium ulcerans hypothetical protein 0.0024 0.0035 0.0038
Loa Loa (eye worm) MH2 domain-containing protein 0.0363 0.1406 0.4312
Onchocerca volvulus 0.0098 0.0334 0.0898
Echinococcus multilocularis protein patched 0.0051 0.0146 0.0146
Toxoplasma gondii ABC1 family protein 0.0071 0.0226 0.5424
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0084 0.0319
Trypanosoma brucei glucosidase, putative 0.0037 0.0091 0.371
Brugia malayi Glycosyl hydrolases family 31 protein 0.0169 0.0621 0.1906
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0226 0.0856
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0034
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0038 0.0038
Echinococcus multilocularis lamin dm0 0.0105 0.0365 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0148 0.0455
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0054 0.2189
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0074 0.0238 0.9718
Brugia malayi hypothetical protein 0.0485 0.1897 0.5818
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0017 0.0406
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0043 0.1811
Mycobacterium ulcerans lipase LipD 0.0071 0.0226 0.0341
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0005 0.0016
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0153
Schistosoma mansoni smad1 5 8 and 0.0025 0.004 0.015
Leishmania major cathepsin L-like protease 0.0016 0.0005 0.021
Onchocerca volvulus 0.0016 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.002 0.0019 0.0058
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.004 0.004
Schistosoma mansoni nuclear receptor 0.0024 0.0038 0.0145
Echinococcus granulosus lamin 0.0105 0.0365 0.1342
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0019 0.0051
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0139 0.0512
Loa Loa (eye worm) hypothetical protein 0.0027 0.005 0.0153
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0167 0.6825
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0019 0.0051
Echinococcus multilocularis protein dispatched 1 0.0058 0.0175 0.0175
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0011 0.5
Echinococcus multilocularis muscleblind protein 0.018 0.0668 0.0668
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0366 0.1416 0.5373
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0038 0.014
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0017 0.0682
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.144 0.4416
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0243 0.0744
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0215 0.0809 0.2481
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0091 0.0245
Echinococcus multilocularis snurportin 1 0.0372 0.144 0.144
Schistosoma mansoni alpha-glucosidase 0.0145 0.0526 0.1997
Brugia malayi cytoplasmic intermediate filament protein 0.0056 0.0167 0.0513
Onchocerca volvulus 0.0158 0.0575 0.1547
Echinococcus granulosus Dipeptidyl peptidase 9 0.0056 0.0167 0.0615
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0146 0.0146
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0148 0.0563
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.005 0.019
Brugia malayi RNA recognition motif domain containing protein 0.0256 0.0974 0.2988
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0038 0.0117
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0005 0.0005
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0089 0.0326
Schistosoma mansoni smad1 5 8 and 0.0025 0.004 0.015
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0148 0.0455
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0148 0.0148
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0148 0.0563
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0038 0.0145
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0089 0.3619
Loa Loa (eye worm) hypothetical protein 0.0071 0.0226 0.0692
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1577 0.6302 1
Brugia malayi Importin beta-1 subunit 0.0035 0.008 0.0246
Onchocerca volvulus 0.0936 0.3719 1
Brugia malayi conserved hypotetical protein 0.0024 0.0038 0.0117
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0118 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0034
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0005 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0035 0.1442
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0089 0.2133
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0019 0.0286
Loa Loa (eye worm) RNA binding protein 0.0256 0.0974 0.2988
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0148 0.0455
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0148 0.0399
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.042 0.042
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0089 0.0239
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0017 0.0017
Schistosoma mansoni inositol monophosphatase 0.0037 0.0089 0.0337
Echinococcus multilocularis geminin 0.0334 0.1288 0.1288
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.002 0.0019 0.0051
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.005 0.0153
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.0012
Schistosoma mansoni ets-related 0.0228 0.0859 0.3261
Echinococcus granulosus tar DNA binding protein 0.0256 0.0974 0.3584
Onchocerca volvulus 0.0105 0.0365 0.0981
Brugia malayi MH1 domain containing protein 0.0025 0.004 0.0121
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0245 0.5894
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0089 0.3619
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0117
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0148 0.0563
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0017 0.0682
Brugia malayi hypothetical protein 0.0049 0.0137 0.042
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.004 0.0121
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0245 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0043 0.1037
Loa Loa (eye worm) hypothetical protein 0.0049 0.0137 0.042
Brugia malayi RNA, U transporter 1 0.0099 0.0339 0.1041
Onchocerca volvulus 0.0052 0.0148 0.0399
Schistosoma mansoni ran 0.0026 0.0043 0.0164
Mycobacterium ulcerans TetR family transcriptional regulator 0.1577 0.6302 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0091 0.1366
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.018 0.0666 0.0666
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0215 0.0659
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0043 0.176
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0084 0.0319
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0017 0.0062
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0226 0.0304
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0139 0.5676
Entamoeba histolytica cysteine protease, putative 0.0016 0.0005 0.0077
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0019 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0035 0.0056
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0146 0.0536
Schistosoma mansoni alpha glucosidase 0.0037 0.0091 0.0345
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0043 0.0132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0005 0.0014
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.002 0.0019 0.0019
Echinococcus multilocularis lamin 0.0105 0.0365 0.0365
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.2636 0.2636
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0017 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Schistosoma mansoni Smad4 0.0025 0.004 0.015
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0005 0.021
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0038 0.0117
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0019 0.0051
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0226 0.0358
Loa Loa (eye worm) hypothetical protein 0.0071 0.0226 0.0692
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0339 0.104
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0074 0.0238 0.3578
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0038 0.0117
Leishmania major cathepsin L-like protease 0.0016 0.0005 0.021
Brugia malayi exodeoxyribonuclease III family protein 0.0074 0.0238 0.0731
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0148 0.0455
Echinococcus granulosus muscleblind protein 0.018 0.0668 0.2457
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0005 0.0014
Leishmania major hypothetical protein, conserved 0.0076 0.0245 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0062 0.0192 0.0589
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0117
Onchocerca volvulus Huntingtin homolog 0.0148 0.0537 0.1443
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0038 0.0038
Schistosoma mansoni smad 0.0025 0.004 0.015
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0017 0.0052
Brugia malayi steroid hormone receptor 0.0052 0.0148 0.0455
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0427 0.162
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0148 0.0455
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0005 0.0014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0017 0.0017
Brugia malayi Serine carboxypeptidase S28 family protein 0.002 0.0019 0.0058
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0118 0.0416 0.0416
Leishmania major cathepsin L-like protease 0.0016 0.0005 0.021
Echinococcus multilocularis muscleblind protein 1 0.018 0.0668 0.0668
Brugia malayi nuclear receptor NHR-88 0.0052 0.0148 0.0455
Echinococcus granulosus snurportin 1 0.0372 0.144 0.5297
Schistosoma mansoni hypothetical protein 0.018 0.0666 0.2527
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0189 0.7707
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0148 0.0563
Echinococcus granulosus microtubule associated protein 2 0.0668 0.2636 0.9696
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0148 0.0148
Brugia malayi Cathepsin L-like precursor 0.0016 0.0005 0.0016
Entamoeba histolytica hypothetical protein 0.018 0.0666 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0215 0.0659
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0005 0.021
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.042 0.1543
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0148 0.0546
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0621 0.0621
Schistosoma mansoni intermediate filament proteins 0.0105 0.0365 0.1384
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0017 0.0689
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0091 0.1366
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0243 0.0243
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0625 0.2301
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0279 0.1067 0.3274
Onchocerca volvulus 0.0016 0.0005 0.0014
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0005 0.0077
Brugia malayi Pre-SET motif family protein 0.0118 0.0416 0.1276
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0148 0.0455
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0148 0.0455
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0074 0.0238 0.9718
Brugia malayi hypothetical protein 0.0076 0.0245 0.0752
Loa Loa (eye worm) hypothetical protein 0.018 0.0668 0.2048
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0038 0.014
Brugia malayi prolyl oligopeptidase family protein 0.0168 0.0617 0.1891
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0019 0.0051
Echinococcus multilocularis lysosomal alpha glucosidase 0.0169 0.0621 0.0621
Echinococcus granulosus survival motor neuron protein 1 0.0485 0.1897 0.6979
Brugia malayi Pre-SET motif family protein 0.0823 0.326 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0084 0.3434
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0455
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 0.1113 0.3413
Schistosoma mansoni hypothetical protein 0.0147 0.0534 0.2026
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0139 0.0139
Loa Loa (eye worm) intermediate filament protein 0.0105 0.0365 0.1119
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0226 0.0358
Trichomonas vaginalis esterase, putative 0.0071 0.0226 0.0607
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0056 0.0167 0.0513
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0279 0.1067 0.3274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Brugia malayi nuclear receptor RXR 0.0027 0.005 0.0153
Treponema pallidum exodeoxyribonuclease (exoA) 0.0074 0.0238 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0056 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0118 0.0416 0.1276
Brugia malayi hypothetical protein 0.0019 0.0017 0.0052
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0035 0.0531
Loa Loa (eye worm) nuclear hormone receptor 0.0133 0.0476 0.146
Brugia malayi Smad1 0.0025 0.004 0.0121
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0074 0.0238 0.0731
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0148 0.0563
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0084 0.031
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0245 1
Leishmania major hypothetical protein, conserved 0.0071 0.0226 0.9203
Loa Loa (eye worm) ctsf protein 0.0016 0.0005 0.0016
Brugia malayi Fli-1 protein 0.0228 0.0859 0.2636
Mycobacterium tuberculosis Conserved protein 0.0071 0.0226 0.0358
Echinococcus granulosus RUN 0.0019 0.0017 0.0062
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0068 0.0215 0.0815
Loa Loa (eye worm) hypothetical protein 0.0101 0.0346 0.1062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0148 0.0546
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0005 0.0014
Entamoeba histolytica hypothetical protein 0.018 0.0666 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.1067 0.1067
Brugia malayi hypothetical protein 0.0027 0.005 0.0153
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0074 0.0238 1
Onchocerca volvulus 0.0016 0.0005 0.0014
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0189 0.7707
Loa Loa (eye worm) hypothetical protein 0.0071 0.0226 0.0692
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0226 0.0607
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0038 0.0117
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0084 0.0226
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0017 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.0416 0.1578
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0043 0.0043
Brugia malayi Serine protease Z688.6 precursor 0.002 0.0019 0.0058
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0019 0.0051
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0366 0.1416 0.521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0148 0.0455
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0189 0.7707
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0034
Echinococcus granulosus Smad4 0.0025 0.004 0.0146
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0823 0.326 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0005 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0226 0.0607
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0035 0.0108
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0038 0.0038
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0148 0.0563
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.1067 0.405
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.008 0.3273
Entamoeba histolytica hypothetical protein 0.018 0.0666 1
Plasmodium vivax vivapain-2 0.0016 0.0005 0.0124
Brugia malayi Cytochrome P450 family protein 0.0047 0.0131 0.0401
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.002 0.0019 0.0051
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0074 0.0238 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0139 0.5676
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0005 0.0014
Mycobacterium ulcerans transcriptional regulator 0.1577 0.6302 1
Brugia malayi hypothetical protein 0.0024 0.0038 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0148 0.0455
Schistosoma mansoni lamin 0.0105 0.0365 0.1384
Loa Loa (eye worm) hypothetical protein 0.0051 0.0146 0.0447
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0226 0.083
Onchocerca volvulus 0.0016 0.0005 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0146 0.0392
Brugia malayi nuclear receptor NHR-88 0.0024 0.0038 0.0117
Schistosoma mansoni hypothetical protein 0.0372 0.144 0.5463
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0073 0.0116
Loa Loa (eye worm) hypothetical protein 0.0068 0.0215 0.0659
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Leishmania major cathepsin L-like protease 0.0062 0.0189 0.7707
Loa Loa (eye worm) hypothetical protein 0.0136 0.0488 0.1497
Leishmania major importin beta-1 subunit, putative 0.0028 0.0054 0.2189
Loa Loa (eye worm) hypothetical protein 0.0024 0.0035 0.0108
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0226 0.0607
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0054 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0091 0.371
Schistosoma mansoni hypothetical protein 0.0334 0.1288 0.4887
Brugia malayi ecdysone receptor 0.0024 0.0038 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.1067 0.405
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0005 0.0014
Echinococcus granulosus lysosomal alpha glucosidase 0.0169 0.0621 0.2286
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0168 0.0617 0.1658
Schistosoma mansoni alpha-glucosidase 0.0145 0.0526 0.1997
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0118 0.0416 0.1578
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0035 0.0038
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0043 0.176
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0038 0.0038
Brugia malayi Calcitonin receptor-like protein seb-1 0.0215 0.0809 0.2481
Schistosoma mansoni hypothetical protein 0.0049 0.0138 0.0524
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0139 0.5841
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.002 0.0019 0.0778
Schistosoma mansoni patched 1 0.0051 0.0146 0.0553
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0017 0.0402
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0035 0.0038
Mycobacterium ulcerans hypothetical protein 0.0071 0.0226 0.0341
Echinococcus multilocularis smad 0.0025 0.004 0.004
Trichomonas vaginalis ran, putative 0.0026 0.0043 0.0116
Loa Loa (eye worm) beta-lactamase 0.0071 0.0226 0.0692
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0056 0.0167 0.6822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0043 0.1037
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0005 0.002
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0038 0.0117
Onchocerca volvulus 0.0019 0.0017 0.0045
Brugia malayi MH2 domain containing protein 0.0025 0.004 0.0121
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0038 0.0103
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0038 0.0038
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.002 0.0019 0.0051
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0148 0.0455
Loa Loa (eye worm) cysteine protease 0.0016 0.0005 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0148 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0189 0.7707
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0189 0.7707
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0011 0.0269
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0139 0.0374
Brugia malayi CHE-14 protein 0.0051 0.0146 0.0447
Onchocerca volvulus 0.0024 0.0038 0.0103
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0139 0.0374
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0485 0.1897 0.5818
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0043 0.176
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0084 0.0226
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0007 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.1067 0.405
Schistosoma mansoni hypothetical protein 0.0068 0.0215 0.0815
Echinococcus multilocularis survival motor neuron protein 1 0.0485 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.0147 0.0534 0.1638
Leishmania major cathepsin L-like protease 0.0062 0.0189 0.7707
Schistosoma mansoni hypothetical protein 0.0034 0.0077 0.0291
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0117
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0056 0.0167 0.6822
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0148 0.0546
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0005 0.021
Loa Loa (eye worm) hypothetical protein 0.0052 0.0148 0.0455
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0148 0.0563
Echinococcus granulosus histone lysine methyltransferase setb 0.0118 0.0416 0.153
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0117
Onchocerca volvulus Huntingtin homolog 0.0148 0.0537 0.1443
Loa Loa (eye worm) hypothetical protein 0.0024 0.0038 0.0117
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.018 0.0666 0.245
Schistosoma mansoni inositol monophosphatase 0.0037 0.0089 0.0337
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0077 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0256 0.0974 0.3696
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.002 0.0019 0.0286
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0148 0.0563
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1577 0.6302 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0215 0.079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0189 0.7707
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0089 0.0239
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0017 0.0027
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.004 0.0121
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0156 0.0156
Schistosoma mansoni ap endonuclease 0.0074 0.0238 0.0904
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0148 0.0148
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0226 0.0607
Mycobacterium leprae Probable lipase LipE 0.0071 0.0226 0.0304
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.2636 1
Loa Loa (eye worm) fibroinase 0.0016 0.0005 0.0016
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0091 0.371
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.002 0.0019 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0019 0.0051

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 1.86 uM PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) = 4.977 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 8.852 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 11.416 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
IC50 (functional) > 1.108 uM PubChem BioAssay. Fluorescence-based cell-based primary high throughput dose response assay to identify antagonists of the Galanin Receptor 3 (GalR3). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 8.799 uM PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay to identify inhibitors of COUP-TFII (NR2F2). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 85.394 uM PubChem BioAssay. Counterscreen for inhibitors of COUP-TFII (NR2F2): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2995 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9093 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Hit Validation in HepG2 Cells using COP promoter. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1095 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8048 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.5686 uM PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Confirmation of Cherrypicks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 46.4515 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 281.8383 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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