Detailed information for compound 1312811

Basic information

Technical information
  • TDR Targets ID: 1312811
  • Name: N-(3-cyclohexylsulfanylpropyl)-1-(4-ethylthie no[2,3-d]pyrrole-5-carbonyl)piperidine-4-carb oxamide
  • MW: 461.684 | Formula: C24H35N3O2S2
  • H donors: 1 H acceptors: 2 LogP: 4.45 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(cc2c1ccs2)C(=O)N1CCC(CC1)C(=O)NCCCSC1CCCCC1
  • InChi: 1S/C24H35N3O2S2/c1-2-27-20-11-16-31-22(20)17-21(27)24(29)26-13-9-18(10-14-26)23(28)25-12-6-15-30-19-7-4-3-5-8-19/h11,16-19H,2-10,12-15H2,1H3,(H,25,28)
  • InChiKey: PIQZRWDDNTVPDX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(cyclohexylthio)propyl]-1-[(4-ethyl-5-thieno[2,3-d]pyrrolyl)-oxomethyl]-4-piperidinecarboxamide
  • N-[3-(cyclohexylthio)propyl]-1-(4-ethylthieno[2,3-d]pyrrole-5-carbonyl)isonipecotamide
  • N-(3-cyclohexylsulfanylpropyl)-1-(4-ethylthieno[2,3-d]pyrrol-5-yl)carbonyl-piperidine-4-carboxamide
  • MLS000878677
  • SMR000096451
  • MLS000119530

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcium channel, voltage-dependent, T type, alpha 1H subunit Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog Get druggable targets OG5_129328 All targets in OG5_129328
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129328 All targets in OG5_129328
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129328 All targets in OG5_129328
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0497 0.7817
Trypanosoma brucei protein kinase, putative 0.005 0.0224 0.3522
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0171 0.3206
Brugia malayi prolyl oligopeptidase family protein 0.0117 0.0636 0.1476
Loa Loa (eye worm) hypothetical protein 0.0071 0.0351 0.0815
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0351 0.0361
Trypanosoma brucei prolyl oligopeptidase, putative 0.0028 0.0087 0.1361
Loa Loa (eye worm) fli-1 protein 0.022 0.127 0.2948
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0117 0.0636 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0497 0.7817
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0351 0.0732
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0161 0.2997
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0041 0.0168 0.1264
Schistosoma mansoni hypothetical protein 0.0135 0.0749 0.1611
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0041 0.0168 0.1264
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0117 0.0636 0.062
Loa Loa (eye worm) prolyl oligopeptidase 0.0348 0.2054 0.4769
Echinococcus multilocularis tumor protein p63 0.0673 0.4057 0.4046
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0041 0.0168 0.1264
Leishmania major trypanothione reductase 0.0047 0.0206 0.3241
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0161 0.2533
Loa Loa (eye worm) hypothetical protein 0.0135 0.0749 0.1738
Onchocerca volvulus 0.0071 0.0351 0.171
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0117 0.0636 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0497 0.3747
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0206 0.0204
Trypanosoma brucei ISWI complex protein 0.0016 0.0013 0.021
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0497 0.1052
Onchocerca volvulus 0.0041 0.0168 0.0816
Brugia malayi Ets-domain containing protein 0.0073 0.0363 0.0842
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.0041 0.0168 0.1264
Schistosoma mansoni lamin 0.0056 0.0264 0.0548
Echinococcus multilocularis lamin 0.0056 0.0264 0.0247
Entamoeba histolytica hypothetical protein 0.0071 0.0356 0.7162
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0017 0.0271
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0356 0.075
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0389
Entamoeba histolytica hypothetical protein 0.0071 0.0356 0.7162
Schistosoma mansoni rab6-interacting 0.0019 0.0035 0.0048
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0368 0.0776
Loa Loa (eye worm) hypothetical protein 0.0475 0.2839 0.659
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0024 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.0271
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0117 0.0636 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0088 0.0156
Mycobacterium ulcerans transcriptional regulator 0.1522 0.927 1
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0224 0.0453
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0028 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0082
Echinococcus multilocularis musashi 0.0056 0.0264 0.0247
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.014 0.2809
Schistosoma mansoni alpha glucosidase 0.0036 0.014 0.0276
Toxoplasma gondii hypothetical protein 0.0028 0.0087 0.112
Schistosoma mansoni ap endonuclease 0.004 0.0161 0.0323
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0117 0.0108
Leishmania major hypothetical protein, conserved 0.0016 0.0013 0.021
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0141 0.2215
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0035 0.0039
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0351 0.0288
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0351 0.0335
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0041 0.0168 0.1264
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0035 0.0947
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.1055 0.2281
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0351 0.0361
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.1055 0.2281
Echinococcus granulosus prolyl endopeptidase 0.0028 0.0087 0.0152
Toxoplasma gondii ABC1 family protein 0.0071 0.0351 0.5401
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0017 0.0271
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.0271
Trypanosoma cruzi oligopeptidase b 0.0028 0.0087 0.1361
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0185 0.1055 0.2448
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0041 0.0168 0.2638
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0497 0.3747
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0161 0.4303
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0095 0.0078
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0087 0.1741
Schistosoma mansoni tar DNA-binding protein 0.0313 0.1842 0.4004
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0035 0.0039
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1522 0.927 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0264 0.0612
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.0087 0.1741
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0067 0.1056
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.0759 0.458 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0018 0.0042
Brugia malayi Ets-domain containing protein 0.0073 0.0363 0.0842
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0024 0.0007
Echinococcus granulosus acylamino acid releasing enzyme 0.0028 0.0087 0.0152
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0041 0.0168 0.1264
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0161 0.0374
Schistosoma mansoni ap endonuclease 0.004 0.0161 0.0323
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0351 0.0361
Loa Loa (eye worm) RNA binding protein 0.0313 0.1842 0.4275
Plasmodium falciparum peptidase, putative 0.0028 0.0087 0.3671
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.092 0.0904
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0497 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0202 0.0413
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0348 0.2054 0.4465
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0513 0.1191
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0171 0.3442
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.014 0.0324
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0161 0.0155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.1055 0.2274
Echinococcus multilocularis RUN 0.0019 0.0035 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0351 0.2648
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0017 0.0009
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0141 0.1062
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.0048
Loa Loa (eye worm) hypothetical protein 0.0044 0.0185 0.043
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0202 0.0405
Schistosoma mansoni alpha-glucosidase 0.014 0.078 0.1679
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0313 0.1842 0.4275
Echinococcus granulosus survival motor neuron protein 1 0.0475 0.2839 0.6185
Echinococcus granulosus RUN 0.0019 0.0035 0.0039
Schistosoma mansoni hypothetical protein 0.0063 0.0302 0.0632
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0082
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0018 0.0002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0302 0.0285
Loa Loa (eye worm) hypothetical protein 0.0071 0.0351 0.0815
Schistosoma mansoni inositol monophosphatase 0.0036 0.0141 0.0279
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.0201
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0095 0.0178
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0117 0.0636 1
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0264 0.0612
Mycobacterium tuberculosis Conserved protein 0.0071 0.0351 0.0361
Mycobacterium tuberculosis Conserved protein 0.0071 0.0351 0.0361
Brugia malayi hypothetical protein 0.0024 0.0067 0.0156
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0171 0.0397
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0084 0.0147
Schistosoma mansoni Smad4 0.0016 0.0018 0.0011
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0028 0.0087 0.1361
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.1134 0.2632
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.014 0.1052
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0224 0.4308
Loa Loa (eye worm) TAR-binding protein 0.0313 0.1842 0.4275
Trypanosoma cruzi ISWI complex protein 0.0016 0.0013 0.021
Onchocerca volvulus 0.0029 0.0095 0.0461
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0041 0.0168 0.3374
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0017 0.013
Mycobacterium ulcerans lipase LipD 0.0071 0.0351 0.0361
Echinococcus granulosus lamin dm0 0.0056 0.0264 0.054
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0161 0.324
Echinococcus multilocularis survival motor neuron protein 1 0.0475 0.2839 0.2827
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0264 0.0612
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0095 0.0178
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.0749 0.1738
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0087 0.1361
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0067 0.1493
Loa Loa (eye worm) hypothetical protein 0.0039 0.0158 0.0368
Loa Loa (eye worm) hypothetical protein 0.0198 0.1134 0.2632
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1522 0.927 1
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0224 0.0207
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0206 0.155
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0171 0.1289
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0041 0.0168 0.1264
Brugia malayi Serine protease Z688.6 precursor 0.0041 0.0168 0.0389
Brugia malayi Bromodomain containing protein 0.0039 0.0158 0.0367
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0497 0.0481
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.0271
Onchocerca volvulus 0.0097 0.0513 0.2498
Brugia malayi hypothetical protein 0.0019 0.0035 0.0082
Giardia lamblia Alanyl dipeptidyl peptidase 0.0028 0.0087 0.1445
Brugia malayi hypothetical protein 0.0475 0.2839 0.659
Loa Loa (eye worm) hypothetical protein 0.0214 0.1234 0.2864
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0224 0.3342
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0497 0.1154
Brugia malayi prolyl oligopeptidase family protein 0.0348 0.2054 0.4769
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0206 0.0478
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0067 0.1056
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0161 0.1214
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0171 0.0337
Plasmodium vivax glutathione reductase, putative 0.0047 0.0206 0.5651
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0202 0.0413
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.014 0.1052
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.014 0.2196
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.014 0.0324
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0302 0.0624
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0017 0.0271
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0024 0.0016
Echinococcus granulosus lamin 0.0056 0.0264 0.054
Loa Loa (eye worm) hypothetical protein 0.0042 0.0173 0.0402
Onchocerca volvulus 0.0019 0.0035 0.0171
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0017 0.0271
Echinococcus granulosus smad 0.0016 0.0018 0.0002
Brugia malayi Smad1 0.0016 0.0018 0.0042
Brugia malayi MH2 domain containing protein 0.0016 0.0018 0.0042
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0024 0.0024
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.092 0.1978
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.014 0.1052
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.014 0.1052
Schistosoma mansoni inositol monophosphatase 0.0036 0.0141 0.0279
Loa Loa (eye worm) hypothetical protein 0.0062 0.0298 0.0692
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0059 0.0042
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0059 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0313 0.1842 0.4004
Trypanosoma cruzi oligopeptidase b 0.0028 0.0087 0.1361
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0171 0.0337
Schistosoma mansoni smad1 5 8 and 0.0016 0.0018 0.0011
Schistosoma mansoni ets-related 0.022 0.127 0.2752
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0117 0.0636 1
Mycobacterium tuberculosis Probable reductase 0.0107 0.0576 0.0604
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0497 0.3747
Brugia malayi hypothetical protein 0.0089 0.0466 0.1082
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0171 0.0154
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0141 0.2215
Mycobacterium leprae Probable lipase LipE 0.0071 0.0351 0.0288
Loa Loa (eye worm) inositol-1 0.0036 0.0141 0.0327
Echinococcus granulosus intermediate filament protein 0.0056 0.0264 0.054
Loa Loa (eye worm) hypothetical protein 0.0024 0.0067 0.0156
Echinococcus multilocularis tar DNA binding protein 0.0313 0.1842 0.1828
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0497 0.3747
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0206 0.155
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0224 0.0207
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.1198 0.9029
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0161 0.0155
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.065 0.0683
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0067 0.1056
Loa Loa (eye worm) hypothetical protein 0.0071 0.0351 0.0815
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0103 0.0239
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.014 0.1052
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0018 0.0001
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1522 0.927 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0035 0.0018
Brugia malayi RNA recognition motif domain containing protein 0.0313 0.1842 0.4275
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0171 0.0154
Plasmodium falciparum thioredoxin reductase 0.0047 0.0206 1
Brugia malayi MH2 domain containing protein 0.0016 0.0018 0.0042
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0759 0.458 0.457
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0293 0.0604
Schistosoma mansoni zinc finger protein 0.002 0.004 0.0059
Entamoeba histolytica hypothetical protein 0.0071 0.0356 0.7162
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0206 0.5651
Schistosoma mansoni lipoxygenase 0.0054 0.0247 0.0513
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.0271
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0302 0.0701
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0028 0.0087 0.016
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0368 0.0379
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.092 0.2135
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0224 0.3522
Schistosoma mansoni hypothetical protein 0.0063 0.0302 0.0632
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0168 0.1264
Loa Loa (eye worm) hypothetical protein 0.0071 0.0351 0.0815
Schistosoma mansoni alpha-glucosidase 0.014 0.078 0.1679
Trichomonas vaginalis set domain proteins, putative 0.0229 0.1326 1
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0497 0.1059
Mycobacterium ulcerans beta-lactamase 0.0071 0.0351 0.0361
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0017 0.0271
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0161 0.7616
Echinococcus multilocularis prolyl endopeptidase 0.0028 0.0087 0.0069
Schistosoma mansoni hypothetical protein 0.0071 0.0356 0.075
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0224 0.1688
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0171 0.0337
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0497 0.3747
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.1402 0.3253
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0368 0.5786
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0141 0.8597
Onchocerca volvulus 0.0229 0.1326 0.6457
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0171 0.1289
Loa Loa (eye worm) hypothetical protein 0.0063 0.0302 0.0701
Loa Loa (eye worm) hypothetical protein 0.0055 0.0257 0.0597
Brugia malayi beta-lactamase 0.0071 0.0351 0.0815
Giardia lamblia Serine peptidase, putative 0.0041 0.0168 0.3136
Echinococcus granulosus zinc finger protein 0.002 0.004 0.005
Onchocerca volvulus 0.0094 0.0497 0.2419
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.0271
Entamoeba histolytica hypothetical protein 0.0071 0.0356 0.7162
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.065 0.0683
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0576 0.0604
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0714 0.4308 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0451 0.2691 0.289
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0117 0.0636 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.0028 0.0087 0.0421
Leishmania major oligopeptidase b 0.0028 0.0087 0.1361
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0041 0.0168 0.0151
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.1134 0.2632
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0224 0.1688
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0017 0.5
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0171 0.0154
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0117 0.0636 0.1363
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0067 0.2642
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0041 0.0168 0.3374
Schistosoma mansoni lamin 0.0056 0.0264 0.0548
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0389
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0141 0.0271
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0141 0.2215
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.1402 0.3253
Echinococcus multilocularis smad 0.0016 0.0018 0.0001
Schistosoma mansoni hypothetical protein 0.0097 0.0513 0.1094
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0497 0.2419
Onchocerca volvulus 0.0056 0.0264 0.1283
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0363 0.0757
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.0181
Loa Loa (eye worm) glutathione reductase 0.0047 0.0206 0.0478
Schistosoma mansoni tar DNA-binding protein 0.0313 0.1842 0.4004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.1134 0.2632
Loa Loa (eye worm) hypothetical protein 0.0089 0.0466 0.1082
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.014 0.2809
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.065 0.0683
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.0087 0.1741
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0161 0.2533
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0224 0.0453
Trypanosoma cruzi prolyl endopeptidase 0.0028 0.0087 0.1361
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.0181
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.014 0.1052
Leishmania major hypothetical protein, conserved 0.0071 0.0351 0.5526
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0171 0.269
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0224 0.0461
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0028 0.0087 0.0075
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0351 0.0361
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0351 0.0815
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0028 0.0087 0.1741
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0224 0.3522
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0095 0.1253
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0171 0.1289
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0143 0.0276
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0035 0.0018
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0041 0.0168 0.1264
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0224 0.3522
Brugia malayi Serine carboxypeptidase S28 family protein 0.0041 0.0168 0.0389
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0302 0.0624
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.0087 0.0201
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0041 0.0168 0.0338
Trypanosoma brucei polo-like protein kinase 0.0094 0.0497 0.7817
Plasmodium falciparum glutathione reductase 0.0047 0.0206 1
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0141 0.0124
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0017 0.0271
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0171 0.269
Onchocerca volvulus 0.0071 0.0351 0.171
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0356 0.0742
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0084 0.0067
Loa Loa (eye worm) hypothetical protein 0.0071 0.0351 0.0815
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0351 0.074
Brugia malayi RNA binding protein 0.0313 0.1842 0.4275
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0028 0.0087 0.112
Echinococcus granulosus tar DNA binding protein 0.0313 0.1842 0.3999
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0041 0.0168 0.1264
Brugia malayi hypothetical protein 0.0071 0.0356 0.0826
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0028 0.0087 0.0075
Brugia malayi hypothetical protein 0.0016 0.0014 0.0032
Trichomonas vaginalis esterase, putative 0.0071 0.0351 0.2648
Brugia malayi Bromodomain containing protein 0.0077 0.0389 0.0903
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0103 0.0239
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0171 0.269
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0028 0.0087 0.1361
Loa Loa (eye worm) hypothetical protein 0.0071 0.0351 0.0815
Loa Loa (eye worm) hypothetical protein 0.0099 0.0523 0.1214
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0523 0.1116
Toxoplasma gondii prolyl endopeptidase 0.0028 0.0087 0.112
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.014 0.1052
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.014 0.2196
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0041 0.0168 0.1264
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0161 0.0374
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.014 0.1052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0351 0.074
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0206 0.3241
Giardia lamblia Alanyl dipeptidyl peptidase 0.0028 0.0087 0.1445
Schistosoma mansoni smad1 5 8 and 0.0016 0.0018 0.0011
Brugia malayi Doublecortin family protein 0.0019 0.0035 0.0082
Loa Loa (eye worm) prolyl oligopeptidase 0.0028 0.0087 0.0201
Schistosoma mansoni intermediate filament proteins 0.0056 0.0264 0.0548
Loa Loa (eye worm) hypothetical protein 0.0041 0.0171 0.0397
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0161 0.0315
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0141 0.1998
Trypanosoma brucei oligopeptidase b 0.0028 0.0087 0.1361
Brugia malayi follicle stimulating hormone receptor 0.0714 0.4308 1
Schistosoma mansoni gabp alpha 0.0073 0.0363 0.0765
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0161 1
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.0041 0.0168 0.2638
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0141 0.2215
Echinococcus granulosus Smad4 0.0016 0.0018 0.0002
Brugia malayi MH1 domain containing protein 0.0016 0.0018 0.0042
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0041 0.0168 0.1264
Brugia malayi MH2 domain containing protein 0.0242 0.1402 0.3253
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0161 0.2533
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.0041 0.0168 0.1264
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.014 0.1978
Loa Loa (eye worm) beta-lactamase 0.0071 0.0351 0.0815
Brugia malayi beta-lactamase family protein 0.0071 0.0351 0.0815
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0224 0.3522
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0041 0.0168 0.033
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0087 0.1361
Echinococcus granulosus GPCR family 2 0.0063 0.0302 0.0624
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0363 0.0346
Brugia malayi hypothetical protein 0.0019 0.0035 0.0082
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0018 0.0001
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0497 0.1154
Schistosoma mansoni hypothetical protein 0.0063 0.0302 0.0632
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0348 0.2054 0.2041
Brugia malayi MAP kinase sur-1 0.005 0.0224 0.052
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0363 0.0842
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0028 0.0087 0.1741
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0017 0.0271
Mycobacterium tuberculosis Probable peptidase 0.0028 0.0087 0.0075
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.092 0.2135
Schistosoma mansoni tar DNA-binding protein 0.0313 0.1842 0.4004
Toxoplasma gondii thioredoxin reductase 0.0047 0.0206 0.3052
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0224 0.3522
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0351 0.0361
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0035 0.0082
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0224 0.052
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.065 0.0613
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0028 0.0087 0.0652
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0351 0.0361
Schistosoma mansoni kinase 0.0048 0.0213 0.0438
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0302 0.0701
Brugia malayi hypothetical protein 0.0152 0.0853 0.1981
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0161 0.0144
Brugia malayi glutathione reductase 0.0047 0.0206 0.0478
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0028 0.0087 0.1361
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0141 0.2834
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0351 0.0361
Brugia malayi Thioredoxin reductase 0.0047 0.0206 0.0478
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.1055 0.1039
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0087 0.0652
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0041 0.0168 0.1264
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0214 0.1234 0.2864
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0017 0.0271
Loa Loa (eye worm) hypothetical protein 0.0072 0.0362 0.084
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0017 0.013
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0389
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0351 0.0815
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0161 0.1214
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0759 0.458 1
Brugia malayi MH1 domain containing protein 0.0016 0.0018 0.0042
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.0041 0.0168 0.2638
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0018 0.0002
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0576 0.0604
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0017 0.004
Brugia malayi intermediate filament protein 0.0056 0.0264 0.0612
Brugia malayi Pre-SET motif family protein 0.0029 0.0095 0.022
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0351 0.2648
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0351 0.5526
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0035 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0168 0.1264
Loa Loa (eye worm) hypothetical protein 0.0152 0.0853 0.1981
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0356 0.0339
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0185 0.1055 0.2448
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.0271
Schistosoma mansoni hypothetical protein 0.0021 0.0047 0.0073
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0368 0.0768
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.0201
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0017 0.0271
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0047 0.0109
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0041 0.0168 0.1264
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0368 0.0776
Schistosoma mansoni survival motor neuron protein 0.0097 0.0513 0.1094
Giardia lamblia Kinase, PLK 0.0094 0.0497 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0143 0.0126
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0351 0.2648
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.1055 0.1039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.1055 0.2274
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0206 0.0189
Brugia malayi TAR-binding protein 0.0313 0.1842 0.4275
Mycobacterium ulcerans TetR family transcriptional regulator 0.1522 0.927 1
Schistosoma mansoni hypothetical protein 0.0063 0.0302 0.0632
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.1055 0.2281
Trypanosoma brucei trypanothione reductase 0.0047 0.0206 0.3241
Brugia malayi Pre-SET motif family protein 0.0201 0.1155 0.2682
Schistosoma mansoni tar DNA-binding protein 0.0313 0.1842 0.4004
Loa Loa (eye worm) hypothetical protein 0.0046 0.0202 0.0469
Echinococcus multilocularis lamin dm0 0.0056 0.0264 0.0247
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.0041 0.0168 0.1264
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0161 1
Onchocerca volvulus 0.0056 0.0264 0.1283
Giardia lamblia Thymus-specific serine protease precursor 0.0041 0.0168 0.3136
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0141 0.1062
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0576 0.0604
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0576 0.0604
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.0087 0.0201
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0018 0.0011
Trypanosoma cruzi ISWI complex protein 0.0016 0.0013 0.021
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0087 0.2074
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0035 0.0535
Brugia malayi PHD-finger family protein 0.0025 0.0074 0.0171
Loa Loa (eye worm) Smad1 0.0016 0.0018 0.0042
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0028 0.0087 0.016
Toxoplasma gondii serine carboxypeptidase s28 protein 0.0041 0.0168 0.2432
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0141 0.1062
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.0201
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0028 0.0087 0.1361
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0028 0.0087 0.016
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.014 0.0123
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0302 0.0701
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0576 0.0604
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.092 0.0904
Echinococcus granulosus tumor protein p63 0.0673 0.4057 0.8854
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0171 0.0345
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.0087 0.0201
Echinococcus multilocularis zinc finger protein 0.002 0.004 0.0023
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0351 0.2648
Schistosoma mansoni rab6-interacting 0.0019 0.0035 0.0048
Schistosoma mansoni bromodomain containing protein 0.0065 0.0315 0.0661
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0247 0.0231
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0059 0.01
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0368 0.0379
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0224 0.3522
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0497 0.3747
Schistosoma mansoni lipoxygenase 0.0019 0.0035 0.0048
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0368 0.0379
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0224 0.1688
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0302 0.0285
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0018 0.0042
Trypanosoma brucei glucosidase, putative 0.0036 0.014 0.2196
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0351 0.2648
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0497 0.7817
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0141 0.0134
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0368 0.0379
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0017 0.0271
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.1155 0.2682
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0293 0.0276
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0351 1
Schistosoma mansoni polycystin 1-related 0.0019 0.0035 0.0048
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.0041 0.0168 0.3374
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0368 0.0351
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.0087 0.1741
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0206 0.0414
Brugia malayi Fli-1 protein 0.022 0.127 0.2948
Brugia malayi Serine protease Z688.6 precursor 0.0041 0.0168 0.0389
Schistosoma mansoni smad 0.0016 0.0018 0.0011
Echinococcus granulosus Dipeptidyl peptidase 9 0.0117 0.0636 0.1356
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0202 0.0185
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0497 0.3747
Mycobacterium tuberculosis Conserved protein 0.0071 0.0351 0.0361
Loa Loa (eye worm) hypothetical protein 0.0041 0.0168 0.0389
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0161 0.2533
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0067 0.0806
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0035 0.0018
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0348 0.2054 1
Onchocerca volvulus 0.0071 0.0351 0.171
Loa Loa (eye worm) hypothetical protein 0.0027 0.0084 0.0196
Toxoplasma gondii exonuclease III APE 0.004 0.0161 0.2324
Trypanosoma brucei prolyl endopeptidase 0.0028 0.0087 0.1361
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0351 0.5526
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0171 0.0345
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0224 0.3522
Echinococcus multilocularis GPCR, family 2 0.0063 0.0302 0.0285
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0247 0.0505
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0576 0.0533
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0224 0.1688
Onchocerca volvulus 0.0152 0.0853 0.4154
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0368 0.5668
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0028 0.0087 0.1361
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0117 0.0034
Leishmania major hypothetical protein, conserved 0.0024 0.0067 0.1056
Loa Loa (eye worm) hypothetical protein 0.0056 0.0264 0.0612
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0067 0.2642
Echinococcus multilocularis acylamino acid releasing enzyme 0.0028 0.0087 0.0069
Echinococcus multilocularis Smad4 0.0016 0.0018 0.0001
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0351 0.0361
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0028 0.0066
Plasmodium vivax SET domain protein, putative 0.0029 0.0095 0.232
Schistosoma mansoni loxhd1 0.0019 0.0035 0.0048
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0348 0.2054 0.447
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0028 0.0087 0.1361
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.014 0.2196
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.014 0.1052
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0171 0.269
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0351 0.0361
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0351 0.5526
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.014 0.0268
Brugia malayi Inositol-1 0.0036 0.0141 0.0327
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0028 0.0087 0.0652
Onchocerca volvulus 0.0019 0.0035 0.0171
Brugia malayi beta-lactamase family protein 0.0071 0.0351 0.0815
Mycobacterium ulcerans hypothetical protein 0.0071 0.0351 0.0361
Onchocerca volvulus 0.0099 0.0523 0.2546
Schistosoma mansoni smad1 5 8 and 0.0016 0.0018 0.0011

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) 3.51 uM PUBCHEM_BIOASSAY: Inhibitors of T-Type Calcium Channel. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID449739, AID463087, AID493021, AID493022, AID493023, AID493041, AID504579, AID504584, AID504619, AID504628] ChEMBL. No reference
EC50 (binding) = 25 um PUBCHEM_BIOASSAY: Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase. (Class of assay: confirmatory) [Related pubchem assays: 1663 (Primary HTS), 1678 (Summary of Project)] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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