Detailed information for compound 131324

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 452.609 | Formula: C26H32N2O3S
  • H donors: 2 H acceptors: 3 LogP: 5.46 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(OC(C)(C)C)N[C@H]([C@H](C[C@H](c1nccs1)Cc1ccccc1)O)Cc1ccccc1
  • InChi: 1S/C26H32N2O3S/c1-26(2,3)31-25(30)28-22(17-20-12-8-5-9-13-20)23(29)18-21(24-27-14-15-32-24)16-19-10-6-4-7-11-19/h4-15,21-23,29H,16-18H2,1-3H3,(H,28,30)/t21-,22+,23+/m1/s1
  • InChiKey: PVPPHFPSWBSHQG-VJBWXMMDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0054 0.0294
Mycobacterium tuberculosis Conserved protein 0.0039 0.0026 0.0023
Echinococcus granulosus GPCR family 2 0.008 0.0075 0.0923
Schistosoma mansoni hypothetical protein 0.008 0.0075 0.0411
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0004 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0111 0.1383
Loa Loa (eye worm) hypothetical protein 0.0031 0.0017 0.0399
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0026 0.0645
Echinococcus granulosus metabotropic glutamate receptor 2 0.0075 0.0069 0.0847
Loa Loa (eye worm) hypothetical protein 0.008 0.0074 0.1966
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0027 0.0742
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.027 0.0267
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0091 0.1129
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0014 0.0317
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0009 0.0006
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0032 0.0803
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0003 0.0007
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0009 0.1424
Loa Loa (eye worm) hypothetical protein 0.008 0.0075 0.1993
Leishmania major importin beta-1 subunit, putative 0.0025 0.001 0.0231
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0075 0.0923
Echinococcus granulosus lamin dm0 0.0081 0.0076 0.0933
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.0206 0.2583
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0027 0.0742
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0155 0.078
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0004 0.0044
Schistosoma mansoni survival motor neuron protein 0.0052 0.0041 0.022
Brugia malayi mbt repeat family protein 0.0049 0.0038 0.135
Loa Loa (eye worm) hypothetical protein 0.0022 0.0006 0.0108
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0027 0.0124
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0032 0.1129
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.0336 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.0336 1
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0076 0.2713
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0004 0.0146
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0099 0.0097 0.2582
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0004 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0004 0.0044
Echinococcus granulosus dna polymerase eta 0.002 0.0004 0.0018
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.001 0.0243
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0026 0.0023
Schistosoma mansoni thyroid hormone receptor 0.002 0.0004 0.0011
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.008 0.2872
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0052
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.003 0.0847
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0004 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0645
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0091 0.0502
Leishmania major cytochrome p450-like protein 0.0019 0.0003 0.0017
Mycobacterium tuberculosis Conserved protein 0.0039 0.0026 0.0023
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0027 0.0024
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.003 0.0769
Brugia malayi hypothetical protein 0.0111 0.0111 0.3985
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0026 0.0133
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0004 0.013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0091 0.3269
Entamoeba histolytica hypothetical protein 0.0111 0.0111 1
Onchocerca volvulus Huntingtin homolog 0.0125 0.0128 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0002 0.0078
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0004 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0026 0.5441
Schistosoma mansoni DNA polymerase eta 0.002 0.0004 0.0008
Toxoplasma gondii FATC domain-containing protein 0.0025 0.001 0.1652
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0004 0.0044
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0011 0.1742
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0009 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0054 0.1943
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0004 0.0024
Schistosoma mansoni importin beta-1 0.0031 0.0017 0.0082
Trichomonas vaginalis esterase, putative 0.0039 0.0026 0.5441
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0046 0.13
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0004 0.0011
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0051 0.0276
Echinococcus multilocularis protein dispatched 1 0.0048 0.0037 0.018
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0004 0.0336
Entamoeba histolytica Ran family GTPase 0.0023 0.0007 0.0458
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0051 1
Brugia malayi hypothetical protein 0.0125 0.0128 0.4564
Echinococcus multilocularis muscleblind protein 0.0148 0.0155 0.078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0004 0.0052
Onchocerca volvulus Huntingtin homolog 0.0125 0.0128 1
Schistosoma mansoni metabotropic glutamate receptor 0.0044 0.0032 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0004 0.0146
Schistosoma mansoni hypothetical protein 0.0111 0.0111 0.0615
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0004 0.001
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0098 0.0542
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0111 0.0558
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0148
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0009 0.0191
Loa Loa (eye worm) inositol-1 0.004 0.0027 0.0677
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.1778 1
Brugia malayi Receptor family ligand binding region containing protein 0.0023 0.0008 0.0271
Schistosoma mansoni hypothetical protein 0.0296 0.0329 0.1839
Leishmania major hypothetical protein, conserved 0.0026 0.0011 0.0256
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0004 0.0146
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1681 0.1959 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0004 0.0044
Brugia malayi TAR-binding protein 0.0063 0.0054 0.1943
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0004 0.0146
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0004 0.0146
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.0278 0.1411
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.003 0.6483
Brugia malayi mbt repeat family protein 0.0049 0.0038 0.135
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0027 0.2269
Brugia malayi Metabotropic glutamate receptor precursor. 0.009 0.0086 0.3084
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0004 0.0146
Echinococcus granulosus metabotropic glutamate receptor 5 0.0111 0.0111 0.1373
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0254 0.028 1
Trichomonas vaginalis ran, putative 0.0023 0.0007 0.1152
Echinococcus granulosus tar DNA binding protein 0.0063 0.0054 0.066
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0004 0.0044
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0004 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0004 0.0024
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.003 0.0847
Plasmodium vivax importin-beta 2, putative 0.0031 0.0017 0.515
Onchocerca volvulus 0.0085 0.008 0.6172
Brugia malayi follicle stimulating hormone receptor 0.023 0.0251 0.8962
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0027 0.5048
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0052
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.0307 0.1718
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0645
Brugia malayi beta-lactamase family protein 0.0039 0.0026 0.0922
Leishmania major DNA polymerase eta, putative 0.002 0.0004 0.0044
Schistosoma mansoni lamin 0.0081 0.0076 0.0415
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0003 0.0017
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0097 0.0483
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0026 0.0707
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0038 0.0972
Onchocerca volvulus 0.0039 0.0026 0.1758
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0038 0.045
Echinococcus granulosus lamin 0.0081 0.0076 0.0933
Echinococcus granulosus expressed conserved protein 0.0093 0.009 0.1106
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0009 0.1296
Echinococcus granulosus importin subunit beta 1 0.0031 0.0017 0.0185
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0051 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0004 0.0052
Echinococcus multilocularis dna polymerase eta 0.002 0.0004 0.0007
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0004 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0075 0.0373
Loa Loa (eye worm) hypothetical protein 0.0049 0.0038 0.0972
Leishmania major DNA polymerase kappa, putative 0.002 0.0004 0.0044
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0149 0.439
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0004 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0091 0.0502
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0014 0.0317
Schistosoma mansoni hypothetical protein 0.008 0.0075 0.0411
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0097 0.1196
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0007 0.0026
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0007 0.0063
Echinococcus granulosus serine protein kinase ATM 0.0025 0.001 0.0103
Loa Loa (eye worm) glutamate receptor 0.0035 0.0022 0.0544
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0004 0.001
Echinococcus granulosus intermediate filament protein 0.0081 0.0076 0.0933
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0051 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0254 0.028 1
Schistosoma mansoni coup transcription factor 0.002 0.0004 0.0011
Brugia malayi cytochrome P450 0.0019 0.0003 0.0098
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0003 0.0017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0004 0.0024
Mycobacterium ulcerans TetR family transcriptional regulator 0.8513 1 1
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0026 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.003 0.0356
Trypanosoma brucei unspecified product 0.002 0.0004 0.0044
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0004 0.004
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0168 0.0165
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.026 0.7046
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0011 0.0256
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0007 0.1152
Brugia malayi RNA binding protein 0.0063 0.0054 0.1943
Leishmania major cytochrome p450-like protein 0.0019 0.0003 0.0017
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0046 0.1634
Loa Loa (eye worm) hypothetical protein 0.0148 0.0155 0.4168
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0007 0.015
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0038 0.045
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0004 0.0024
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0046 0.13
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0054 0.1426
Giardia lamblia DINP protein human, muc B family 0.002 0.0004 0.0336
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0004 0.0024
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0054 0.0267
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0023 0.0008 0.0147
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0026 0.0707
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0004 0.0001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0054 0.1426
Brugia malayi nuclear hormone receptor 0.002 0.0004 0.0146
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0011 0.3708
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0019 0.0003 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0004 0.0146
Echinococcus multilocularis protein patched 0.0042 0.003 0.0144
Loa Loa (eye worm) RNA binding protein 0.0063 0.0054 0.1426
Brugia malayi CHE-14 protein 0.0042 0.003 0.1084
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0026 0.0023
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0004 0.0024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0011 0.0234
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.0206 0.1043
Entamoeba histolytica hypothetical protein 0.0024 0.0009 0.0583
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0052
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0019 0.0003 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0645
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.001 0.0046
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0014 0.0011
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0041 0.1473
Schistosoma mansoni ran 0.0023 0.0007 0.0028
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0026 0.5441
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0004 0.0146
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0022 0.0019
Mycobacterium leprae Probable lipase LipE 0.0039 0.0026 0.0023
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0038 0.0182
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0038 0.02
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0004 0.001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0004 0.0146
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0102 0.0101 0.0555
Brugia malayi Inositol-1 0.004 0.0027 0.0964
Brugia malayi metabotropic glutamate receptor type 2 0.0044 0.0032 0.1145
Mycobacterium ulcerans short chain dehydrogenase 0.0271 0.03 0.0297
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0046 0.8839
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0254 0.028 0.7583
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0004 0.0018
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0046 0.0551
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0026 0.0023
Schistosoma mansoni hypothetical protein 0.0052 0.0041 0.022
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0004 0.0044
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0026 0.0023
Echinococcus multilocularis snurportin 1 0.0329 0.0368 0.187
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0111 0.0615
Brugia malayi Cytochrome P450 family protein 0.0019 0.0003 0.0098
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0052
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.0769
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0051 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0004 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0004 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0004 0.0044
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0004 0.0052
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0011 0.0256
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0046 1
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0017 0.297
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0026 0.5441
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0041 0.1174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0004 0.0052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0091 0.1129
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0075 0.0923
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0004 0.0007
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0004 0.0001
Schistosoma mansoni intermediate filament proteins 0.0081 0.0076 0.0415
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.003 0.0847
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0039 0.0027 0.0665
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0004 0.001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.0251 0.679
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0004 0.0052
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0007 0.015
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0026 0.0299
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0004 0.0001
Entamoeba histolytica hypothetical protein 0.0025 0.001 0.0707
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0004 0.0146
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0046 1
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.003 0.0356
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0023 0.0008 0.0147
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0147 0.0738
Entamoeba histolytica hypothetical protein 0.0025 0.001 0.0743
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0026 0.0133
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0075 0.0373
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0009 0.5
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0017 0.0075
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0027 0.0308
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0004 0.0011
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0027 0.0742
Schistosoma mansoni patched 1 0.0042 0.003 0.0158
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0046 0.13
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0147 0.1827
Brugia malayi Cytochrome P450 family protein 0.0028 0.0014 0.0492
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0026 0.0023
Mycobacterium ulcerans beta-lactamase 0.0039 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.0253 0.0278 0.7544
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0046 0.13
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0019 0.0003 0.0017
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0046 0.13
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0051 0.1471
Brugia malayi hypothetical protein 0.0026 0.0011 0.0384
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0147
Echinococcus multilocularis musashi 0.0081 0.0076 0.0377
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0051 0.0622
Echinococcus granulosus dna polymerase kappa 0.002 0.0004 0.0018
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0149 0.439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0091 0.0502
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0004 0.0044
Onchocerca volvulus 0.0081 0.0076 0.5811
Toxoplasma gondii ABC1 family protein 0.0039 0.0026 0.4809
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0026 0.0121
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0004 0.0011
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0022 0.0019
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.008 0.0399
Schistosoma mansoni ran 0.0023 0.0007 0.0028
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.001 0.0243
Leishmania major hypothetical protein, conserved 0.0039 0.0026 0.0707
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0007 0.0137
Schistosoma mansoni inositol monophosphatase 0.004 0.0027 0.014
Loa Loa (eye worm) hypothetical protein 0.0148 0.0155 0.4168
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0026 0.5441
Loa Loa (eye worm) beta-lactamase 0.0039 0.0026 0.0645
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0026 0.0922
Schistosoma mansoni thyroid hormone receptor 0.002 0.0004 0.0011
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0051 0.1329
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0004 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0004 0.0146
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0046 0.0222
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0017 0.0437
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0149 0.439
Mycobacterium ulcerans lipase LipD 0.0039 0.0026 0.0023
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0004 0.0011
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.003 0.0144
Brugia malayi RNA, U transporter 1 0.0088 0.0084 0.2993
Brugia malayi beta-lactamase family protein 0.0039 0.0026 0.0922
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0014 0.0347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0004 0.0052
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.001 0.0368
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.0336 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0026 0.0023
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0014 0.0347
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0004 0.0008
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0004 0.0052
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0046 0.0222
Onchocerca volvulus 0.0081 0.0076 0.5811
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0009 0.0006
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0027 0.5711
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0017 0.0437
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0004 0.0011
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.001 0.1778
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0026 0.0023
Trichomonas vaginalis importin beta-1, putative 0.0025 0.001 0.1778
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0027 0.0127
Entamoeba histolytica hypothetical protein 0.0111 0.0111 1
Schistosoma mansoni hypothetical protein 0.069 0.0792 0.4448
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0046 0.1186
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.026 0.7046
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.8513 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0052
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.001 0.187
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0111 0.0111 0.0555
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0026 0.5441
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0006 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0004 0.0146
Echinococcus multilocularis lamin dm0 0.0081 0.0076 0.0377
Brugia malayi MAP kinase sur-1 0.0055 0.0046 0.163
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0026 0.0023
Loa Loa (eye worm) glutamate receptor 0.009 0.0086 0.2297
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.0368 1
Brugia malayi Muscleblind-like protein 0.0148 0.0155 0.5532
Loa Loa (eye worm) hypothetical protein 0.0174 0.0185 0.4996
Brugia malayi MH2 domain containing protein 0.0238 0.026 0.9297
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0004 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0004 0.0146
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0002 0.0001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0051 0.0251
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0617
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.004
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0004 0.001
Brugia malayi beta-lactamase 0.0039 0.0026 0.0922
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0014 0.0317
Loa Loa (eye worm) hypothetical protein 0.0111 0.0111 0.2966
Echinococcus multilocularis GPCR, family 2 0.008 0.0075 0.0373
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0148
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0009 0.0006
Schistosoma mansoni nuclear hormone receptor 0.002 0.0004 0.0011
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0046 0.13
Schistosoma mansoni inositol monophosphatase 0.004 0.0027 0.014
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.001 0.0041
Mycobacterium ulcerans hypothetical protein 0.0159 0.0168 0.0165
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0052
Schistosoma mansoni cytochrome P450 0.0019 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0004 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0004 0.0044
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0081 0.0076 0.2728
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0075 0.1993
Brugia malayi intermediate filament protein 0.0081 0.0076 0.2713
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0002 0.0001
Schistosoma mansoni hypothetical protein 0.0174 0.0185 0.1029
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0009 0.0734
Onchocerca volvulus 0.0039 0.0026 0.1758
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0002 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0004 0.0052
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0004 0.001
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0004 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0004 0.0044
Schistosoma mansoni hypothetical protein 0.008 0.0075 0.0411
Loa Loa (eye worm) hypothetical protein 0.0055 0.0046 0.1189
Toxoplasma gondii hypothetical protein 0.0049 0.0038 0.7254
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0011 0.3708
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0645
Mycobacterium ulcerans hypothetical protein 0.0039 0.0026 0.0023
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0076 0.2014
Entamoeba histolytica hypothetical protein 0.0111 0.0111 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.0128 0.3428
Schistosoma mansoni hypothetical protein 0.008 0.0075 0.0411
Loa Loa (eye worm) hypothetical protein 0.0038 0.0025 0.0617
Brugia malayi Cytochrome P450 family protein 0.0028 0.0014 0.0492
Leishmania major GTP-binding protein, putative 0.0023 0.0007 0.015
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.003 0.0847
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.001 0.0231
Loa Loa (eye worm) cytochrome P450 0.0019 0.0003 0.0015
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0009 0.0191
Plasmodium falciparum importin beta, putative 0.0031 0.0017 1
Brugia malayi Latrophilin receptor protein 2 0.008 0.0075 0.2686
Entamoeba histolytica hypothetical protein 0.0111 0.0111 1
Brugia malayi Importin beta-1 subunit 0.0031 0.0017 0.0599
Brugia malayi steroid hormone receptor 0.002 0.0004 0.0146
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0046 0.0549
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0097 0.8646
Mycobacterium ulcerans transcriptional regulator 0.8513 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0046 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0007 0.1018
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0014 0.0347
Brugia malayi ecdysteroid receptor 0.002 0.0004 0.0146
Mycobacterium tuberculosis Probable oxidoreductase 0.0271 0.03 0.0297
Brugia malayi Cytochrome P450 family protein 0.006 0.0051 0.1816
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.0336 1
Leishmania major cytochrome p450-like protein 0.0028 0.0014 0.0347
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0046 0.0551
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.0185 0.6615
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0046 0.13
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0097 0.3456
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0046 0.0222
Brugia malayi nuclear receptor NHR-88 0.002 0.0004 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0004 0.0146
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.0278 0.3494
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0027 0.0742
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0051 0.0049
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0645
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.008 0.044
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0011 0.0256
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0038 0.02
Echinococcus granulosus snurportin 1 0.0329 0.0368 0.4631
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0046 0.0222
Echinococcus granulosus geminin 0.069 0.0792 1
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0038 0.02
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0007 0.0257
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0004 0.0044
Echinococcus multilocularis lamin 0.0081 0.0076 0.0377
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0007 0.015
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0004 0.0011
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0011 0.191
Echinococcus granulosus muscleblind protein 0.0148 0.0155 0.1931
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0091 0.0456
Mycobacterium ulcerans AcrR family transcriptional regulator 0.8513 1 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0004 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0004 0.0044
Schistosoma mansoni hypothetical protein 0.0329 0.0368 0.206
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0046 0.0245
Schistosoma mansoni hypothetical protein 0.069 0.0792 0.4448
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.008 0.0989
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0004 0.001
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0075 0.0069 0.0342
Mycobacterium tuberculosis Conserved protein 0.0039 0.0026 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0054 0.0294
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0027 0.5711
Echinococcus multilocularis geminin 0.069 0.0792 0.4038
Loa Loa (eye worm) hypothetical protein 0.0052 0.0042 0.1076
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0052
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0076 0.2014
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0054 0.0294
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0026 0.0707
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0091 0.2439
Schistosoma mansoni hypothetical protein 0.0019 0.0003 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0091 0.0456
Loa Loa (eye worm) MBCTL1 0.0055 0.0046 0.1189
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0004 0.0044
Echinococcus multilocularis expressed conserved protein 0.0093 0.009 0.0447
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0004 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0046 0.0244
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0027 0.0314
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0051 0.0276
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0009 0.1296
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0004 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0054 0.0294
Loa Loa (eye worm) hypothetical protein 0.0081 0.0076 0.2014
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0026 0.0023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0075 0.2686
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0046 1
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0046 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0027 0.5711
Loa Loa (eye worm) hypothetical protein 0.0254 0.028 0.7583
Trypanosoma brucei protein kinase, putative 0.0055 0.0046 0.13
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0004 0.0044
Loa Loa (eye worm) hypothetical protein 0.0125 0.0128 0.3428
Echinococcus multilocularis 0.0019 0.0003 0.0003
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0038 0.0182
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0148
Onchocerca volvulus 0.0039 0.0026 0.1758
Loa Loa (eye worm) hypothetical protein 0.0039 0.0026 0.0645
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0004 0.001
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0027 1
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0046 0.0549
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0004 0.0044
Schistosoma mansoni metabotropic glutamate receptor 0.0075 0.0069 0.0377
Onchocerca volvulus 0.0049 0.0038 0.2726
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0054 0.0294
Brugia malayi hypothetical protein 0.0253 0.0278 0.995
Loa Loa (eye worm) hypothetical protein 0.0085 0.008 0.2136
Echinococcus granulosus FTZ F1 alpha 0.002 0.0004 0.0024
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.001 0.1778
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0004 0.0336
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0038 0.2726
Onchocerca volvulus 0.0052 0.0041 0.3005
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0004 0.013
Schistosoma mansoni lamin 0.0081 0.0076 0.0415
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0003 0.0114

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) NT 0 nM Inhibitory activity against HIV replication in MOLT-4 cells. ChEMBL. No reference
Ki (binding) = 3000 nM Inhibitory activity against HIV-1 protease ChEMBL. No reference
Ki app (binding) = 3000 nM Inhibitory activity against HIV-1 protease ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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