Detailed information for compound 1339183

Basic information

Technical information
  • TDR Targets ID: 1339183
  • Name: 2-chloro-4,5-difluoro-N-[2-[(2-nitrophenyl)am ino]ethyl]benzamide
  • MW: 355.724 | Formula: C15H12ClF2N3O3
  • H donors: 2 H acceptors: 3 LogP: 4.09 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc(F)c(cc1Cl)F)NCCNc1ccccc1[N+](=O)[O-]
  • InChi: 1S/C15H12ClF2N3O3/c16-10-8-12(18)11(17)7-9(10)15(22)20-6-5-19-13-3-1-2-4-14(13)21(23)24/h1-4,7-8,19H,5-6H2,(H,20,22)
  • InChiKey: LNEPHJDEGGSBDP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • A0167/0007522
  • MLS001183516
  • SMR000502068
  • ZINC04357398
  • 2-Chloro-4,5-difluoro-N-[2-(2-nitroanilino)ethyl]benzamide
  • Benzamide, 2-chloro-4,5-difluoro-N-[2-(2-nitrophenylamino)ethyl]-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0029 0.0103 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0689 0.1116
Schistosoma mansoni loxhd1 0.0019 0.0006 0.0007
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0104 0.0373
Treponema pallidum phosphoglycerate kinase 0.0166 0.1537 0.5357
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0104 0.0373
Echinococcus granulosus phosphoglycerate kinase 1 0.0166 0.1537 0.2012
Schistosoma mansoni amine oxidase 0.002 0.0015 0.002
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0039 0.0208 0.063
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0028 0.0144
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0144 0.0335
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0104 0.0582
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0911 0.1486
Brugia malayi phosphofructokinase 0.0106 0.0911 0.2113
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.018 0.0539
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0111 0.0258
Schistosoma mansoni patched 1 0.0051 0.0336 0.044
Loa Loa (eye worm) hypothetical protein 0.0051 0.0336 0.0779
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0086 0.0703 0.1145
Leishmania major cytochrome p450-like protein 0.0039 0.0208 0.0321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0111 0.0258
Onchocerca volvulus 0.0029 0.0111 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0162 0.0237
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0911 0.2113
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0084 0.0678 0.1105
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0042 0.0097
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0166 0.1537 1
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0111 0.0145
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0103 0.0146
Schistosoma mansoni hypothetical protein 0.0185 0.1729 0.2263
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0144 0.0322
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0039 0.0208 0.063
Brugia malayi hypothetical protein 0.0043 0.0257 0.0596
Schistosoma mansoni tyrosine kinase 0.0078 0.0612 0.0801
Trypanosoma brucei DNA polymerase eta, putative 0.003 0.0117 0.0161
Leishmania major DNA polymerase kappa, putative 0.0044 0.0259 0.0406
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.278 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0689 0.1116
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0006 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0109 0.0142
Echinococcus granulosus tar DNA binding protein 0.0063 0.0463 0.0606
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0039 0.0208 0.063
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0463 0.0463
Brugia malayi Furin-like cysteine rich region family protein 0.0146 0.1323 0.3067
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0472 0.1491
Schistosoma mansoni phosphoglycerate kinase 0.0166 0.1537 0.2012
Echinococcus multilocularis insulin receptor 0.0047 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.0258
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0118 0.1034 0.1034
Chlamydia trachomatis pyruvate kinase 0.0033 0.0144 0.0849
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0039 0.0208 0.063
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0576 0.1335
Echinococcus multilocularis Protein lozenge 0.0054 0.037 0.037
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.062 0.0812
Mycobacterium ulcerans phosphoglycerate kinase 0.0166 0.1537 0.497
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-2) 0.0261 0.252 0.9031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0103 0.0287
Brugia malayi Pre-SET motif family protein 0.0203 0.1923 0.4459
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.007 0.042
Trypanosoma brucei phosphoglycerate kinase 0.0166 0.1537 0.253
Brugia malayi Ets-domain containing protein 0.0079 0.0627 0.1454
Mycobacterium tuberculosis Conserved hypothetical protein 0.003 0.0117 0.0331
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0098 0.0128
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0039 0.0208 0.0314
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0111 0.0111
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0039 0.0208 0.063
Brugia malayi Protein kinase domain containing protein 0.0086 0.0703 0.1629
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1923 0.4459
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.0258
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0111 0.0145
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0166 0.1537 0.6075
Echinococcus granulosus dna polymerase eta 0.003 0.0117 0.0153
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0192 0.0445
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0627 0.1454
Treponema pallidum methylgalactoside ABC transporter, periplasmic galactose-binding protein (mglB-1) 0.0261 0.252 0.9031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.1034 0.3326
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0689 0.1116
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0111 0.0145
Schistosoma mansoni hypothetical protein 0.0049 0.0317 0.0415
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0111 0.0145
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0472 0.1491
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0463 0.0606
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0044 0.0187
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0287 0.2792 0.9067
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0109 0.0142
Brugia malayi Muscleblind-like protein 0.018 0.1683 0.3902
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0911 0.2113
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0689 0.1116
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0111 0.0145
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0015 0.002
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0111 0.0145
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.007 0.0162
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0044 0.0259 0.0795
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.1323 0.1323
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0911 0.3576
Brugia malayi CHE-14 protein 0.0051 0.0336 0.0779
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0111 0.0258
Schistosoma mansoni hypothetical protein 0.0185 0.1729 0.2263
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0433 0.4313 1
Brugia malayi steroid hormone receptor 0.0029 0.0111 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0463 0.0606
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0039 0.0208 0.0321
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0111 0.0258
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0911 0.1493
Plasmodium vivax hypothetical protein, conserved 0.002 0.0015 0.0063
Giardia lamblia DINP protein human, muc B family 0.0044 0.0259 0.0696
Schistosoma mansoni tyrosine kinase 0.0078 0.0612 0.0801
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0339 0.333 0.333
Echinococcus granulosus pyruvate kinase 0.0033 0.0144 0.0189
Trypanosoma cruzi DNA polymerase kappa, putative 0.0085 0.0689 0.1123
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0472 0.0618
Plasmodium vivax phosphoglycerate kinase, putative 0.0166 0.1537 1
Entamoeba histolytica phosphoglycerate kinase, putative 0.0166 0.1537 0.553
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0111 0.0258
Schistosoma mansoni amine oxidase 0.002 0.0015 0.002
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0103 0.0146
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0086 0.0703 0.1629
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.002 0.0015 0.002
Loa Loa (eye worm) CYP4Cod1 0.0074 0.0576 0.1335
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0103 0.037
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0103 0.037
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0039 0.0208 0.063
Loa Loa (eye worm) TK/EGFR protein kinase 0.0146 0.1323 0.3067
Echinococcus granulosus geminin 0.0185 0.1729 0.2263
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0111 0.0258
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0224 0.0224
Schistosoma mansoni terminal deoxycytidyl transferase 0.003 0.0117 0.0153
Plasmodium falciparum pyruvate kinase 0.0033 0.0144 0.0907
Echinococcus multilocularis pyruvate kinase 0.0033 0.0144 0.0144
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1086 0.1086
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0111 0.0145
Brugia malayi hypothetical protein 0.0231 0.2212 0.5128
Plasmodium falciparum phosphoglycerate kinase 0.0166 0.1537 1
Echinococcus multilocularis expressed protein 0.0365 0.3604 0.3604
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0035
Brugia malayi Cytochrome P450 family protein 0.0076 0.0592 0.1372
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0166 0.1537 1
Trypanosoma brucei DNA polymerase IV, putative 0.0071 0.0547 0.0879
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 0.1537 0.2535
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.002 0.0015 0.0063
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0224 0.0348
Schistosoma mansoni tyrosine kinase 0.0047 0.029 0.0379
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0005 0.0006
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0463 0.1074
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0208 0.0321
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0013
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0117 0.027
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0104 0.0641
Brugia malayi 6-phosphofructokinase 0.0106 0.0911 0.2113
Schistosoma mansoni flap endonuclease-1 0.0023 0.0044 0.0058
Echinococcus multilocularis phosphoglycerate kinase 1 0.0166 0.1537 0.1537
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0103 0.035
Echinococcus multilocularis dual specificity 0.0086 0.0703 0.0703
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0104 0.0582
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0339 0.333 0.4358
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0911 0.0911
Echinococcus multilocularis muscleblind protein 0.018 0.1683 0.1683
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0039 0.0208 0.063
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.062 0.062
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0282 0.2745 0.4548
Schistosoma mansoni hypothetical protein 0.0049 0.0317 0.0415
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0109 0.0142
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0144 0.0422
Onchocerca volvulus 0.0433 0.4313 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0192 0.0577
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 0.1537 0.553
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0144 0.0849
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.2212 0.2212
Echinococcus granulosus muscleblind protein 0.018 0.1683 0.2202
Loa Loa (eye worm) hypothetical protein 0.0086 0.0698 0.1618
Schistosoma mansoni thyroid hormone receptor 0.0152 0.1392 0.1822
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0403 0.0528
Schistosoma mansoni tyrosine kinase 0.0078 0.062 0.0812
Onchocerca volvulus 0.0029 0.0103 0.0226
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1258 0.4961
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0339 0.333 0.4358
Toxoplasma gondii aldehyde dehydrogenase 0.0118 0.1034 0.6692
Leishmania major cytochrome p450-like protein 0.0074 0.0576 0.0934
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.278 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0144 0.0215
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0005 0.0011
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.062 0.0812
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0911 0.1192
Trypanosoma brucei phosphoglycerate kinase 0.0061 0.0441 0.0702
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0162 0.0237
Schistosoma mansoni hypothetical protein 0.0043 0.0257 0.0337
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0103 0.0146
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0597 0.6018 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0104 0.0373
Schistosoma mansoni lozenge 0.0054 0.037 0.0485
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0267 0.2581 0.838
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0005 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.1034 0.3326
Trypanosoma brucei DNA polymerase IV, putative 0.0085 0.0689 0.1116
Mycobacterium ulcerans hypothetical protein 0.0314 0.3077 1
Leishmania major pyruvate kinase 0.0033 0.0144 0.0215
Entamoeba histolytica hypothetical protein 0.0043 0.0257 0.0925
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0117 0.0169
Loa Loa (eye worm) hypothetical protein 0.018 0.1683 0.3902
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0689 0.1116
Leishmania major phosphoglycerate kinase C, glycosomal 0.0166 0.1537 0.2535
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0006 0.0006
Schistosoma mansoni inositol monophosphatase 0.004 0.0224 0.0294
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0111 0.0111
Entamoeba histolytica hypothetical protein 0.0043 0.0257 0.0925
Echinococcus multilocularis lysine specific histone demethylase 1A 0.002 0.0015 0.0015
Schistosoma mansoni Lysine-specific histone demethylase 1 0.002 0.0015 0.002
Schistosoma mansoni pyruvate kinase 0.0033 0.0144 0.0189
Brugia malayi Phosphoglycerate kinase 0.0061 0.0441 0.1022
Leishmania major phosphoglycerate kinase B, cytosolic 0.0166 0.1537 0.2535
Entamoeba histolytica protein kinase, putative 0.0086 0.0703 0.2528
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0144 0.0208
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0086 0.0703 0.1145
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0103 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0111 0.0258
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0282 0.2745 0.4544
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0403 0.0403
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0111 0.0245
Entamoeba histolytica hypothetical protein 0.0043 0.0257 0.0925
Schistosoma mansoni tyrosine kinase 0.0078 0.0612 0.0801
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.003 0.0117 0.0153
Schistosoma mansoni lipoxygenase 0.0115 0.1005 0.1316
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.278 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.278 1
Mycobacterium leprae Conserved hypothetical protein 0.0039 0.0208 0.077
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0192 0.0294
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0472 0.0618
Brugia malayi hypothetical protein 0.002 0.0015 0.0035
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0627 0.0821
Brugia malayi 6-phosphofructokinase 0.0106 0.0911 0.2113
Entamoeba histolytica protein kinase domain containing protein 0.0086 0.0703 0.2528
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0192 0.1216
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0042 0.015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0118 0.1034 0.3326
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0001
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0576 0.1335
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.2159 0.5005
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0084 0.0678 0.1105
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0039 0.0208 0.063
Brugia malayi Cytochrome P450 family protein 0.0039 0.0208 0.0482
Loa Loa (eye worm) RNA binding protein 0.0063 0.0463 0.1074
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0111 0.0145
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0039 0.0208 0.063
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.003 0.0117 0.0117
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0028 0.0081
Onchocerca volvulus 0.0029 0.0109 0.0239
Leishmania major pyruvate kinase 0.0033 0.0144 0.0215
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0166 0.1537 0.497
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.278 1
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0166 0.1537 0.553
Schistosoma mansoni hypothetical protein 0.0047 0.0296 0.0387
Echinococcus multilocularis geminin 0.0185 0.1729 0.1729
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0192 0.0329
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0035
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.003 0.0117 0.027
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0224 0.0294
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0111 0.0145
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0463 0.1074
Schistosoma mansoni coup transcription factor 0.0029 0.0111 0.0145
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0208 0.0321
Leishmania major mitochondrial DNA polymerase beta 0.0597 0.6018 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.002 0.0015 0.0063
Toxoplasma gondii cytochrome p450 superfamily protein 0.0039 0.0208 0.1267
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0111 0.0145
Plasmodium falciparum protoporphyrinogen oxidase 0.002 0.0015 0.0063
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0224 0.0807
Schistosoma mansoni ap endonuclease 0.0037 0.0192 0.0251
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1258 0.4059
Brugia malayi Ets-domain containing protein 0.0079 0.0627 0.1454
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0162 0.0237
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0005 0.0005
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.018 0.0659
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0166 0.1537 0.2535
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1062 0.139
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0039 0.0208 0.063
Echinococcus multilocularis 0.0045 0.0275 0.0275
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0224 0.0807
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0911 0.3278
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.002 0.0015 0.0063
Loa Loa (eye worm) fli-1 protein 0.024 0.2302 0.5336
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0103 0.0239
Loa Loa (eye worm) TK/INSR protein kinase 0.0047 0.029 0.0672
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.0258
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0336 0.044
Schistosoma mansoni gabp alpha 0.0079 0.0627 0.0821
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0111 0.0145
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0084 0.0678 0.1098
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0035
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0111 0.0111
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0336 0.044
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0118 0.1034 0.3326
Brugia malayi SWIRM domain containing protein 0.002 0.0015 0.0035
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0111 0.0245
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0689 0.1116
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0111 0.0245
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0144 0.0516
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0144 0.0422
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0039 0.0208 0.063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0111 0.0258
Trypanosoma cruzi DNA polymerase kappa, putative 0.0085 0.0689 0.1123
Echinococcus granulosus expressed protein 0.0365 0.3604 0.4716
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0039 0.0208 0.063
Chlamydia trachomatis phosphoglycerate kinase 0.0166 0.1537 1
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.1034 0.1353
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0039 0.0208 0.063
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0192 0.0445
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.278 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0111 0.0145
Brugia malayi follicle stimulating hormone receptor 0.0226 0.2159 0.5005
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0039 0.0208 0.0321
Onchocerca volvulus 0.0047 0.0296 0.0674
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0192 0.0294
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0192 0.1216
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0441 0.0709
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0039 0.0208 0.063
Brugia malayi Doublecortin family protein 0.0019 0.0006 0.0013
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0911 0.1493
Schistosoma mansoni pyruvate kinase 0.0033 0.0144 0.0189
Echinococcus granulosus RUN 0.0019 0.0006 0.0007
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0104 0.0582
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0039 0.0208 0.063
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0911 0.3278
Loa Loa (eye worm) hypothetical protein 0.0166 0.1537 0.3564
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0111 0.0258
Schistosoma mansoni tyrosine kinase 0.0078 0.062 0.0812
Schistosoma mansoni ap endonuclease 0.0037 0.0192 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0111 0.0258
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0463 0.0606
Echinococcus granulosus pyruvate kinase 0.0033 0.0144 0.0189
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0005 0.0011
Mycobacterium ulcerans DNA polymerase IV 0.0085 0.0689 0.2201
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.007 0.0091
Trypanosoma brucei cytochrome P450, putative 0.0074 0.0576 0.0927
Echinococcus granulosus microtubule associated protein 2 0.0753 0.7641 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0109 0.0614
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0047 0.029 0.0379
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0104 0.0582
Schistosoma mansoni microtubule-associated protein tau 0.0753 0.7641 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0039 0.0208 0.063
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0039 0.0208 0.063
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0911 0.3278
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0441 0.0709
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0006 0.0006
Toxoplasma gondii exonuclease III APE 0.0037 0.0192 0.116
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0103 0.0287
Brugia malayi TAR-binding protein 0.0063 0.0463 0.1074
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0911 0.1192
Brugia malayi Flap endonuclease-1 0.0025 0.007 0.0162
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0006 0.0007
Plasmodium vivax SET domain protein, putative 0.0029 0.0109 0.0674
Echinococcus granulosus expressed conserved protein 0.0112 0.0968 0.1266
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0911 0.1192
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0103 0.037
Mycobacterium tuberculosis Conserved hypothetical protein 0.0314 0.3077 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0006 0.0006
Echinococcus multilocularis protoporphyrinogen oxidase 0.002 0.0015 0.0015
Brugia malayi Cytochrome P450 family protein 0.0074 0.0576 0.1335
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.278 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0111 0.0111
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0039 0.0208 0.063
Trypanosoma cruzi cytochrome P450, putative 0.0074 0.0576 0.0934
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0039 0.0208 0.063
Brugia malayi nuclear receptor NHR-88 0.0029 0.0111 0.0258
Brugia malayi jmjC domain containing protein 0.0057 0.0403 0.0936
Brugia malayi Pre-SET motif family protein 0.0029 0.0109 0.0252
Loa Loa (eye worm) runx1 0.0054 0.037 0.0859
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0039 0.0208 0.063
Giardia lamblia Phosphoglycerate kinase 0.0166 0.1537 0.5415
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0104 0.0641
Schistosoma mansoni survival motor neuron protein 0.0047 0.0296 0.0387
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0103 0.0287
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0192 0.0192
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.1005 0.1005
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0104 0.0125
Loa Loa (eye worm) hypothetical protein 0.018 0.1683 0.3902
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1258 0.4059
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0166 0.1537 1
Brugia malayi hypothetical protein 0.0019 0.0006 0.0013
Schistosoma mansoni ets-related 0.024 0.2302 0.3012
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.1323 0.1731
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0001
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0061 0.0441 0.0709
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0689 0.1116
Mycobacterium leprae Possible D-ribose-binding protein 0.0261 0.252 1
Brugia malayi Cytochrome P450 family protein 0.0074 0.0576 0.1335
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0006 0.0007
Trypanosoma brucei unspecified product 0.0071 0.0547 0.0879
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0111 0.0258
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0403 0.0528
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.1392 0.1392
Entamoeba histolytica hypothetical protein 0.0086 0.0703 0.2528
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0103 0.0287
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.278 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0339 0.333 0.7721
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0104 0.0582
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0144 0.0335
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1086 0.1421
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.007 0.0252
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0403 0.0528
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0039 0.0208 0.063
Schistosoma mansoni rab6-interacting 0.0019 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0173 0.0401
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0074 0.0576 0.1831
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0911 0.3278
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.1005 0.1316
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0064
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0001
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0224 0.0807
Schistosoma mansoni tyrosine kinase 0.0047 0.029 0.0379
Schistosoma mansoni aldehyde dehydrogenase 0.0118 0.1034 0.1353
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0039 0.0208 0.063
Echinococcus multilocularis muscleblind protein 1 0.018 0.1683 0.1683
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0911 0.3017
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0006 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0911 0.3278
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0597 0.6018 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0472 0.0472
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0111 0.0145
Plasmodium vivax protoporphyrinogen oxidase, putative 0.002 0.0015 0.0063
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0192 0.069
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0111 0.0258
Brugia malayi hypothetical protein 0.0433 0.4313 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0086 0.0703 0.1138
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.007 0.0084
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0224 0.0242
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0044 0.0259 0.0406
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0039 0.0208 0.063
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0064
Brugia malayi polk-prov protein 0.0064 0.0474 0.11
Loa Loa (eye worm) hypothetical protein 0.0068 0.0508 0.1178
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0085 0.0689 0.2479
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0224 0.0683
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0086 0.0703 0.1145
Trypanosoma brucei DNA polymerase IV, putative 0.0085 0.0689 0.1116
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0109 0.0109
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0472 0.0761
Schistosoma mansoni hypothetical protein 0.0039 0.0208 0.0272
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0441 0.0709
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1574 0.1574
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0064
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0192 0.069
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0463 0.0606
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.2212 0.2894
Entamoeba histolytica deoxycytidyl transferase, putative 0.003 0.0117 0.0419
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0039 0.0208 0.063
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.278 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0015 0.002
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0911 0.3278
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0103 0.0239
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0192 0.0287
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0028 0.0144
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0144 0.0215
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0111 0.0258
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0224 0.1374
Plasmodium falciparum flap endonuclease 1 0.0025 0.007 0.042
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0039 0.0208 0.063
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0597 0.6018 1
Schistosoma mansoni hypothetical protein 0.0049 0.0317 0.0415
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0224 0.0341
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.0097
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0035
Mycobacterium leprae putative cytochrome p450 0.0039 0.0208 0.077
Schistosoma mansoni phosphoglycerate kinase 0.0166 0.1537 0.2012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0085 0.0689 0.1123
Trypanosoma brucei phosphoglycerate kinase, putative 0.0061 0.0441 0.0702
Loa Loa (eye worm) hypothetical protein 0.0086 0.0698 0.1618
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0287 0.2792 0.9067
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0103 0.0287
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0336 0.0779
Leishmania major DNA polymerase eta, putative 0.003 0.0117 0.0169
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0472 0.1491
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0039 0.0208 0.063
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1043 0.3751
Mycobacterium ulcerans DNA polymerase IV 0.0085 0.0689 0.2201
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1043 0.1365
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0336 0.0336
Brugia malayi cytochrome P450 0.0039 0.0208 0.0482
Echinococcus granulosus insulin receptor 0.0047 0.029 0.0379
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0111 0.0145
Loa Loa (eye worm) hypothetical protein 0.0033 0.0144 0.0335
Loa Loa (eye worm) cytochrome P450 family protein 0.0076 0.0592 0.1372
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0111 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0005 0.0006
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0118 0.1034 0.1697
Schistosoma mansoni hypothetical protein 0.0049 0.0317 0.0415
Loa Loa (eye worm) hypothetical protein 0.0062 0.0456 0.1056
Trypanosoma brucei RNA helicase, putative 0.01 0.0846 0.1377
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0111 0.0258
Loa Loa (eye worm) hypothetical protein 0.0029 0.0109 0.0252
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0282 0.2745 0.4548
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0111 0.0145
Brugia malayi jmjC domain containing protein 0.0057 0.0403 0.0936
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0111 0.0258
Loa Loa (eye worm) hypothetical protein 0.0064 0.0474 0.11
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0039 0.0208 0.063
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0103 0.0287
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0144 0.0335
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0039 0.0208 0.063
Plasmodium vivax hypothetical protein, conserved 0.002 0.0015 0.0063
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0474 0.0758
Echinococcus multilocularis protein patched 0.0051 0.0336 0.0336
Trichomonas vaginalis DNA polymerase eta, putative 0.0085 0.0689 0.2479
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.0911 0.2926
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0028 0.004
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0104 0.0641
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0144 0.0322
Echinococcus multilocularis microtubule associated protein 2 0.0753 0.7641 0.7641
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0144 0.052
Schistosoma mansoni thyroid hormone receptor 0.0152 0.1392 0.1822
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.278 1
Onchocerca volvulus 0.0232 0.2216 0.5131
Brugia malayi Protein kinase domain containing protein 0.0047 0.029 0.0672
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0104 0.0373
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0039 0.0208 0.063
Schistosoma mansoni hypothetical protein 0.0123 0.1086 0.1421
Loa Loa (eye worm) hypothetical protein 0.002 0.0015 0.0035
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0224 0.0348
Brugia malayi Phosphoglycerate kinase 0.0166 0.1537 0.3564
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0403 0.0528
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2216 0.7972
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0109 0.0142
Loa Loa (eye worm) hypothetical protein 0.0029 0.0103 0.0239
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0111 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0689 0.1116
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.01 0.0846 0.1107
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0118 0.1034 0.1353
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0007
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0109 0.0109
Echinococcus multilocularis RUN 0.0019 0.0006 0.0006
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1043 0.2418
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0296 0.0686
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0144 0.052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0111 0.0111
Echinococcus multilocularis pyruvate kinase 0.0026 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.0258
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0039 0.0208 0.063
Echinococcus granulosus dual specificity 0.0086 0.0703 0.0919
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0257 0.0337
Echinococcus multilocularis flap endonuclease 1 0.0025 0.007 0.007
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0039 0.0208 0.063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0111 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0103 0.0287
Loa Loa (eye worm) hypothetical protein 0.0029 0.0103 0.0239
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0111 0.0145
Schistosoma mansoni inositol monophosphatase 0.004 0.0224 0.0294
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0463 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0336 0.1209
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0104 0.0373
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0039 0.0208 0.063
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0192 0.069
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0111 0.0145
Onchocerca volvulus 0.002 0.0015 0.0022
Echinococcus multilocularis dna polymerase eta 0.003 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.0258
Schistosoma mansoni tyrosine kinase 0.0146 0.1323 0.1731
Schistosoma mansoni cytochrome P450 0.0039 0.0208 0.0272
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0103 0.0287
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0144 0.0335
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0259 0.0398
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0144 0.0907
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0039 0.0208 0.063
Entamoeba histolytica Flap nuclease, putative 0.0025 0.007 0.0252
Schistosoma mansoni rab6-interacting 0.0019 0.0006 0.0007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0257 0.0257
Brugia malayi nuclear hormone receptor 0.0029 0.0111 0.0258
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0339 0.333 0.7721
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0111 0.0258
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.007 0.036
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0703 0.0919
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0111 0.0145
Brugia malayi amine oxidase, flavin-containing family protein 0.002 0.0015 0.0035
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0084 0.0678 0.1105
Trypanosoma cruzi DNA polymerase kappa, putative 0.0085 0.0689 0.1123
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0224 0.0807
Echinococcus multilocularis protein dispatched 1 0.0058 0.0411 0.0411
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0104 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0111 0.0258
Mycobacterium ulcerans hypothetical protein 0.0029 0.0103 0.0287
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0472 0.1094
Echinococcus granulosus dna polymerase kappa 0.0085 0.0689 0.0902
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0111 0.0258
Schistosoma mansoni polycystin 1-related 0.0019 0.0006 0.0007
Echinococcus granulosus cytochrome P450 2K1 0.0039 0.0208 0.0272
Echinococcus granulosus flap endonuclease 1 0.0025 0.007 0.0092
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0103 0.035
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0109 0.0142
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0028 0.004
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.278 1
Giardia lamblia Pyruvate kinase 0.0033 0.0144 0.0275
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0111 0.0258
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0144 0.0322
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0039 0.0208 0.063
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.007 0.0091
Onchocerca volvulus 0.002 0.0015 0.0022
Toxoplasma gondii hypothetical protein 0.0096 0.0807 0.5202
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0144 0.0335
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0224 0.0348
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0039 0.0208 0.063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0111 0.0258
Loa Loa (eye worm) hypothetical protein 0.0119 0.1043 0.2418
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.0001
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0104 0.0641
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0061 0.0441 0.0709
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0192 0.0577
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0047 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0231 0.2212 0.5128
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0349 0.081
Echinococcus multilocularis 0.002 0.0015 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0103 0.0287
Brugia malayi hypothetical protein 0.0019 0.0006 0.0013
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0061 0.0441 0.0709
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0403 0.0403
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0257 0.0337
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0192 0.0294
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0005 0.0011
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0627 0.0627
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0039 0.0208 0.063
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.003 0.0117 0.0153
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0463 0.1074
Trypanosoma brucei DNA polymerase kappa, putative 0.0085 0.0689 0.1116
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0102 0.087 0.1423
Loa Loa (eye worm) inositol-1 0.004 0.0224 0.052
Entamoeba histolytica protein kinase, putative 0.0086 0.0703 0.2528
Brugia malayi ecdysteroid receptor 0.0029 0.0111 0.0258
Leishmania major cytochrome p450-like protein 0.0039 0.0208 0.0321
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0192 0.0251
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.0258
Echinococcus multilocularis dna polymerase kappa 0.0085 0.0689 0.0689
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0111 0.0145
Echinococcus multilocularis pyruvate kinase 0.0033 0.0144 0.0144
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0403 0.0936
Schistosoma mansoni lipoxygenase 0.0081 0.0644 0.0843
Schistosoma mansoni DNA polymerase eta 0.003 0.0117 0.0153
Brugia malayi ImpB/MucB/SamB family protein 0.003 0.0117 0.027
Entamoeba histolytica hypothetical protein 0.0043 0.0257 0.0925
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0911 0.2113
Loa Loa (eye worm) hypothetical protein 0.003 0.0117 0.027
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0911 0.3278
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0474 0.0758
Trypanosoma brucei phosphoglycerate kinase 0.0166 0.1537 0.253
Loa Loa (eye worm) hypothetical protein 0.0433 0.4313 1
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0144 0.0208
Echinococcus multilocularis expressed conserved protein 0.0112 0.0968 0.0968
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0403 0.0528
Brugia malayi RNA binding protein 0.0063 0.0463 0.1074
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0064
Brugia malayi Fli-1 protein 0.024 0.2302 0.5336
Loa Loa (eye worm) hypothetical protein 0.0029 0.0111 0.0258
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1043 0.1043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.278 1
Brugia malayi Inositol-1 0.004 0.0224 0.052
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0039 0.0208 0.063
Trypanosoma cruzi cytochrome P450, putative 0.0074 0.0576 0.0934
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0039 0.0208 0.063
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.0911 0.2926
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0039 0.0208 0.063
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0111 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0111 0.0258
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0104 0.0373
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0039 0.0208 0.063
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0192 0.045
Loa Loa (eye worm) cytochrome P450 0.0039 0.0208 0.0482
Echinococcus multilocularis 0.0039 0.0208 0.0208
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0104 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0005 0.0006
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1574 0.206

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) > 11 uM PUBCHEM_BIOASSAY: MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_DryPowder_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
AC50 (functional) > 11 uM PUBCHEM_BIOASSAY: MITF: Counter assay: A375 proliferation Measured in Cell-Based System Using Plate Reader - 2084-03_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488944] ChEMBL. No reference
Potency (functional) 1.0418 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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