Detailed information for compound 1350144

Basic information

Technical information
  • TDR Targets ID: 1350144
  • Name: methyl 4-[[4-dimethylamino-6-[(3,4-dimethylph enyl)amino]-1,3,5-triazin-2-yl]oxy]benzoate
  • MW: 393.439 | Formula: C21H23N5O3
  • H donors: 1 H acceptors: 4 LogP: 4.75 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(cc1)Oc1nc(Nc2ccc(c(c2)C)C)nc(n1)N(C)C
  • InChi: 1S/C21H23N5O3/c1-13-6-9-16(12-14(13)2)22-19-23-20(26(3)4)25-21(24-19)29-17-10-7-15(8-11-17)18(27)28-5/h6-12H,1-5H3,(H,22,23,24,25)
  • InChiKey: PPZSBEALENEFHT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[4-dimethylamino-6-[(3,4-dimethylphenyl)amino]-1,3,5-triazin-2-yl]oxy]benzoic acid methyl ester
  • 4-[[4-dimethylamino-6-[(3,4-dimethylphenyl)amino]-s-triazin-2-yl]oxy]benzoic acid methyl ester
  • MLS000538586
  • ZINC02882195
  • methyl 4-({4-(dimethylamino)-6-[(3,4-dimethylphenyl)amino]-1,3,5-triazin-2-yl}oxy)benzoate
  • SMR000144623

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0153 0.0206 0.0196
Schistosoma mansoni serine/threonine protein kinase 0.0595 0.1732 0.4452
Trichomonas vaginalis CAMK family protein kinase 0.0355 0.0902 0.3299
Loa Loa (eye worm) AUR protein kinase 0.0416 0.1115 0.1106
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.022 0.0437 0.1567
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0126 0.0112 0.0102
Entamoeba histolytica protein kinase, putative 0.0809 0.2472 0.9774
Echinococcus multilocularis casein kinase I alpha 0.0175 0.0282 0.0491
Leishmania major protein kinase A catalytic subunit isoform 2 0.0182 0.0307 0.0984
Giardia lamblia Kinase, PLK 0.0764 0.2319 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0253 0.055 0.0957
Entamoeba histolytica hypothetical protein 0.0341 0.0856 0.326
Brugia malayi Protein kinase domain containing protein 0.033 0.0818 0.0808
Entamoeba histolytica diacylglycerol kinase, putative 0.011 0.0058 0.0043
Echinococcus multilocularis Rac GTPase activating protein 1 0.011 0.0058 0.0101
Echinococcus granulosus fibroblast growth factor receptor 4 0.048 0.1335 0.2757
Entamoeba histolytica protein kinase, putative 0.0153 0.0204 0.0632
Trichomonas vaginalis CMGC family protein kinase 0.0217 0.0426 0.1338
Entamoeba histolytica protein kinase, putative 0.0126 0.0112 0.0262
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0287 0.0668 0.1162
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0115 0.0072 0.0125
Trichomonas vaginalis CAMK family protein kinase 0.025 0.0542 0.1814
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0139 0.0156 0.04
Brugia malayi MAP kinase sur-1 0.0217 0.0426 0.0416
Giardia lamblia Kinase, CMGC CK2 0.0193 0.0345 0.1056
Brugia malayi RhoGEF domain containing protein 0.011 0.0058 0.0047
Trichomonas vaginalis STE family protein kinase 0.0207 0.039 0.1188
Plasmodium vivax casein kinase 1, putative 0.0175 0.0282 0.1511
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0126 0.0112 0.0196
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0217 0.0426 0.1521
Brugia malayi Protein kinase domain containing protein 0.012 0.009 0.008
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0468 0.1296 0.5415
Trichomonas vaginalis CAMK family protein kinase 0.0764 0.2319 0.9139
Onchocerca volvulus Tyrosine kinase homolog 0.1286 0.4121 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0138 0.0128
Echinococcus multilocularis mitogen activated protein kinase 14 0.046 0.1267 0.2205
Trypanosoma cruzi aurora B kinase, putative 0.0416 0.1115 0.4608
Brugia malayi Cam kinase protein 1 0.0126 0.0112 0.0102
Loa Loa (eye worm) hypothetical protein 0.0221 0.044 0.043
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0139 0.0156 0.0271
Loa Loa (eye worm) hypothetical protein 0.0144 0.0173 0.0163
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0325 0.0798 0.0788
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0126 0.0112 0.0112
Leishmania major protein kinase A catalytic subunit 0.0182 0.0307 0.0984
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0139 0.0156 0.04
Schistosoma mansoni serine/threonine protein kinase 0.0652 0.193 0.4962
Trichomonas vaginalis CAMK family protein kinase 0.0315 0.0765 0.2735
Trypanosoma brucei cdc2-related kinase 3 0.033 0.0818 0.2994
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0126 0.0112 0.0102
Loa Loa (eye worm) hypothetical protein 0.0221 0.0441 0.043
Trichomonas vaginalis AGC family protein kinase 0.0155 0.021 0.0447
Echinococcus multilocularis protein kinase c eta type 0.011 0.0058 0.0101
Echinococcus granulosus RNA directed DNA polymerase 0.0128 0.0118 0.0225
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0217 0.0426 0.0416
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0155 0.021 0.0366
Plasmodium falciparum calcium-dependent protein kinase 3 0.0126 0.0112 0.0221
Echinococcus multilocularis protein kinase c iota type 0.0788 0.2399 0.4173
Loa Loa (eye worm) hypothetical protein 0.0115 0.0072 0.0061
Entamoeba histolytica protein kinase, putative 0.0825 0.2528 1
Brugia malayi Pleckstrin Homology Domain 0.0127 0.0114 0.0103
Brugia malayi Casein kinase II, alpha chain 0.0193 0.0345 0.0335
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0416 0.1115 0.194
Loa Loa (eye worm) AGC/NDR protein kinase 0.041 0.1092 0.1083
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0362 0.0928 0.3767
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0217 0.0426 0.1391
Loa Loa (eye worm) hypothetical protein 0.0558 0.1606 0.1597
Schistosoma mansoni serine/threonine protein kinase 0.0512 0.1447 0.3721
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0126 0.0112 0.0005
Schistosoma mansoni serine/threonine kinase 0.025 0.0542 0.1393
Schistosoma mansoni growth factor receptor-bound protein 0.0097 0.0011 0.0027
Echinococcus multilocularis mitogen activated protein kinase 14 0.046 0.1267 0.2205
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0621 0.1821 0.377
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0129 0.0123 0.0233
Onchocerca volvulus 0.012 0.009 0.0178
Echinococcus granulosus protein kinase C gamma type 0.0542 0.1548 0.3202
Brugia malayi Protein kinase domain containing protein 0.0341 0.0856 0.0846
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0182 0.0307 0.0984
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0569 0.1643 0.1634
Brugia malayi Temporarily assigned gene name protein 59 0.0416 0.1115 0.1106
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0776 0.2357 0.2349
Echinococcus multilocularis tyrosine protein kinase shark 0.012 0.009 0.0157
Echinococcus granulosus casein kinase I alpha 0.0175 0.0282 0.0565
Trichomonas vaginalis CAMK family protein kinase 0.0764 0.2319 0.9139
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0747 0.2257 0.4677
Giardia lamblia Kinase, NEK 0.0386 0.1011 0.4075
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.0282 0.0726
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.009 0.008
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.009 0.008
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0362 0.0928 0.1909
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0155 0.021 0.0416
Loa Loa (eye worm) hypothetical protein 0.0277 0.0634 0.0624
Brugia malayi putative serine/threonine kinase SADA gamma 0.0126 0.0112 0.0101
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0182 0.0307 0.1727
Brugia malayi Fibronectin type III domain containing protein 0.0144 0.0173 0.0163
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.025 0.0542 0.0532
Brugia malayi diacylglycerol kinase 0.011 0.0058 0.0047
Schistosoma mansoni protein kinase 0.0621 0.1821 0.4683
Loa Loa (eye worm) hypothetical protein 0.0144 0.0173 0.0163
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.009 0.008
Entamoeba histolytica protein kinase, putative 0.0137 0.0148 0.0407
Entamoeba histolytica protein kinase, putative 0.041 0.1092 0.4212
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0193 0.0345 0.2067
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Echinococcus granulosus casein kinase I alpha 0.0175 0.0282 0.0565
Echinococcus multilocularis cyclin dependent kinase 5 0.033 0.0818 0.1422
Trypanosoma brucei aurora B kinase 0.0416 0.1115 0.4213
Echinococcus granulosus myotubularin protein 13 0.0127 0.0114 0.0215
Leishmania major casein kinase II, putative 0.0193 0.0345 0.1156
Entamoeba histolytica cell division protein kinase 2, putative 0.033 0.0818 0.3106
Toxoplasma gondii histone kinase SNF1, putative 0.0126 0.0112 0.0223
Entamoeba histolytica casein kinase, putative 0.0175 0.0282 0.0947
Schistosoma mansoni serine/threonine protein kinase 0.0652 0.193 0.4962
Echinococcus granulosus cyclin dependent kinase 0.033 0.0818 0.168
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0441 0.1201 0.2089
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0182 0.0307 0.09
Echinococcus multilocularis fibroblast growth factor receptor 4 0.048 0.1335 0.2322
Schistosoma mansoni tyrosine kinase 0.1181 0.376 0.9667
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0253 0.055 0.0957
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0452 0.124 1
Onchocerca volvulus 0.0122 0.0098 0.0197
Plasmodium falciparum casein kinase 2, alpha subunit 0.0193 0.0345 0.2238
Echinococcus multilocularis serine:threonine protein kinase N2 0.041 0.1092 0.19
Echinococcus multilocularis NCK adaptor protein 0.0097 0.0011 0.0019
Brugia malayi RhoGAP domain containing protein 0.0165 0.0245 0.0235
Entamoeba histolytica protein kinase, putative 0.0175 0.0283 0.0949
Echinococcus granulosus rho-associated protein kinase 1 0.0996 0.3119 0.6473
Brugia malayi Protein kinase domain containing protein 0.0315 0.0765 0.0755
Echinococcus granulosus ephrin type A receptor 4 A 0.0199 0.0365 0.0739
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0437 0.1187 0.245
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0126 0.0112 0.0195
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0217 0.0426 0.1521
Echinococcus multilocularis protein kinase c epsilon type 0.0524 0.1488 0.2589
Echinococcus granulosus serine:threonine protein kinase 0.0315 0.0765 0.1571
Echinococcus multilocularis mitogen activated protein kinase 11 0.046 0.1267 0.2205
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0126 0.0112 0.0226
Schistosoma mansoni serine/threonine protein kinase 0.0512 0.1447 0.3721
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0437 0.1187 0.2065
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0355 0.0903 0.1571
Trichomonas vaginalis CMGC family protein kinase 0.033 0.0818 0.2951
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0175 0.0283 0.0566
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.1219 0.389 0.6767
Schistosoma mansoni rac gtpase activating protein 0.011 0.0058 0.0149
Trichomonas vaginalis AGC family protein kinase 0.0155 0.021 0.0447
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0126 0.0112 0.0104
Echinococcus granulosus activin receptor type 0.0119 0.0087 0.0159
Schistosoma mansoni serine/threonine protein kinase 0.0192 0.0338 0.087
Brugia malayi MH2 domain containing protein 0.0144 0.0175 0.0164
Echinococcus multilocularis rho associated protein kinase 0.0996 0.3119 0.5427
Trichomonas vaginalis AGC family protein kinase 0.041 0.1092 0.4082
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0217 0.0426 0.1526
Schistosoma mansoni serine/threonine protein kinase 0.0681 0.203 0.522
Trichomonas vaginalis CK1 family protein kinase 0.0175 0.0282 0.0743
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0217 0.0426 0.1521
Loa Loa (eye worm) TK/ROR protein kinase 0.0106 0.0043 0.0032
Brugia malayi cell division control protein 2 homolog 0.033 0.0818 0.0808
Loa Loa (eye worm) hypothetical protein 0.0238 0.05 0.049
Echinococcus granulosus tyrosine protein kinase Srms 0.012 0.009 0.0166
Brugia malayi Protein kinase c protein 2 0.0296 0.0698 0.0688
Trichomonas vaginalis AGC family protein kinase 0.0416 0.1115 0.4178
Schistosoma mansoni hypothetical protein 0.0205 0.0383 0.0986
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0097 0.0011 0.0027
Entamoeba histolytica protein kinase, putative 0.0362 0.0928 0.3549
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.046 0.1267 0.529
Schistosoma mansoni vesicular amine transporter 0.0139 0.0156 0.04
Brugia malayi Immunoglobulin I-set domain containing protein 0.0099 0.0017 0.0007
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0175 0.0282 0.0272
Echinococcus granulosus c src tyrosine kinase 0.0162 0.0238 0.0473
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.033 0.0818 0.3147
Schistosoma mansoni unc-13 (munc13) 0.0115 0.0072 0.0185
Echinococcus multilocularis calcium activated potassium channel 0.025 0.0542 0.0943
Loa Loa (eye worm) raf kinase 0.011 0.0058 0.0047
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0122 0.0098 0.0051
Echinococcus granulosus geminin 0.0205 0.0383 0.0776
Giardia lamblia Aurora kinase 0.0416 0.1115 0.4547
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0569 0.1643 0.3398
Trichomonas vaginalis CMGC family protein kinase 0.0217 0.0426 0.1338
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Echinococcus granulosus casein kinase i 0.0175 0.0282 0.0565
Schistosoma mansoni serine/threonine protein kinase 0.0123 0.0102 0.0262
Trypanosoma brucei protein kinase, putative 0.0362 0.0928 0.3445
Schistosoma mansoni serine/threonine protein kinase 0.0569 0.1643 0.4223
Echinococcus multilocularis tyrosine protein kinase Fyn 0.021 0.0403 0.0701
Entamoeba histolytica serine/threonine protein kinase, putative 0.0764 0.2319 0.9158
Schistosoma mansoni serine/threonine protein kinase 0.0416 0.1115 0.2867
Trypanosoma cruzi casein kinase, putative 0.0175 0.0282 0.0875
Loa Loa (eye worm) AUR protein kinase 0.0416 0.1115 0.1106
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0126 0.0112 0.0005
Schistosoma mansoni kinase 0.0697 0.2084 0.5358
Echinococcus granulosus aurora kinase A 0.0416 0.1115 0.23
Echinococcus granulosus casein kinase I delta 0.0175 0.0282 0.0565
Schistosoma mansoni serine/threonine protein kinase 0.025 0.0542 0.1393
Trichomonas vaginalis conserved hypothetical protein 0.0153 0.0206 0.043
Plasmodium falciparum glycogen synthase kinase 3 0.0362 0.0928 0.7294
Brugia malayi P38 map kinase family protein 2 0.046 0.1267 0.1258
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0362 0.0928 0.0918
Echinococcus multilocularis death associated protein kinase 1 0.1757 0.5748 1
Schistosoma mansoni serine/threonine protein kinase 0.0437 0.1187 0.3052
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0155 0.021 0.02
Echinococcus granulosus mitogen activated protein kinase 14 0.046 0.1267 0.2617
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0764 0.2319 0.4806
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0182 0.0307 0.0616
Schistosoma mansoni hypothetical protein 0.011 0.0058 0.0149
Schistosoma mansoni hypothetical protein 0.0205 0.0383 0.0986
Schistosoma mansoni serine/threonine protein kinase 0.0341 0.0856 0.2201
Echinococcus granulosus unc 13 munc13 0.0115 0.0072 0.0128
Echinococcus granulosus dual specificity 0.0341 0.0856 0.176
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0217 0.0426 0.1521
Onchocerca volvulus 0.0448 0.1224 0.2941
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.033 0.0818 0.0808
Brugia malayi Hr1 repeat family protein 0.041 0.1092 0.1083
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.022 0.0437 0.157
Echinococcus granulosus cyclin dependent kinase 1 0.033 0.0818 0.168
Echinococcus multilocularis dual specificity 0.0341 0.0856 0.1489
Echinococcus granulosus Glutaredoxin protein 5 0.0399 0.1056 0.2176
Echinococcus multilocularis titin 0.0099 0.0017 0.003
Brugia malayi Protein kinase domain containing protein 0.0825 0.2528 0.252
Loa Loa (eye worm) hypothetical protein 0.0448 0.1224 0.1215
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0362 0.0928 0.3603
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0182 0.0307 0.0616
Onchocerca volvulus Serine\/threonine kinase homolog 0.0764 0.2319 0.5607
Echinococcus multilocularis ephrin type A receptor 4 A 0.0199 0.0365 0.0636
Loa Loa (eye worm) hypothetical protein 0.011 0.0058 0.0047
Onchocerca volvulus 0.012 0.009 0.0178
Loa Loa (eye worm) hypothetical protein 0.0182 0.0307 0.0296
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0165 0.0245 0.0631
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0123 0.0102 0.0091
Leishmania major protein kinase, putative 0.0126 0.0112 0.0114
Echinococcus granulosus serine:threonine protein kinase 0.0315 0.0765 0.1571
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1486 0.4813 1
Schistosoma mansoni protein kinase C mu 0.011 0.0058 0.0149
Loa Loa (eye worm) hypothetical protein 0.011 0.0058 0.0047
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0253 0.055 0.0957
Trypanosoma brucei protein kinase, putative 0.0217 0.0426 0.1391
Echinococcus multilocularis nervana 2 0.0399 0.1056 0.1837
Entamoeba histolytica protein kinase, putative 0.013 0.0126 0.0319
Trichomonas vaginalis CAMK family protein kinase 0.0764 0.2319 0.9139
Schistosoma mansoni hypothetical protein 0.0197 0.0358 0.0921
Onchocerca volvulus 0.012 0.009 0.0178
Plasmodium falciparum casein kinase 1 0.0175 0.0282 0.1694
Loa Loa (eye worm) hypothetical protein 0.011 0.0058 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.0362 0.0928 0.3404
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0768 0.2331 0.4832
Echinococcus granulosus Rac GTPase activating protein 1 0.011 0.0058 0.0098
Brugia malayi Tyrosine-protein kinase abl-1 0.0127 0.0115 0.0105
Schistosoma mansoni tyrosine kinase 0.0398 0.1054 0.2709
Echinococcus granulosus tyrosine protein kinase HCK 0.0156 0.0215 0.0426
Trichomonas vaginalis CMGC family protein kinase 0.0217 0.0426 0.1338
Trichomonas vaginalis CMGC family protein kinase 0.0362 0.0928 0.3404
Brugia malayi serine/threonine-protein kinase 6 0.0416 0.1115 0.1106
Brugia malayi Protein kinase domain containing protein 0.012 0.009 0.008
Schistosoma mansoni tyrosine kinase 0.0681 0.203 0.5219
Giardia lamblia Kinase, CMGC GSK 0.0362 0.0928 0.3697
Echinococcus multilocularis serine:threonine protein kinase 3 0.0776 0.2357 0.4101
Echinococcus granulosus epidermal growth factor receptor 0.0747 0.2257 0.4677
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0175 0.0283 0.0492
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0452 0.124 1
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.009 0.008
Giardia lamblia Kinase, AGC PKA 0.0452 0.124 0.511
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0512 0.1447 0.2518
Entamoeba histolytica PH domain containing protein kinase, putative 0.0468 0.1296 0.5032
Echinococcus multilocularis serine:threonine protein kinase 0.0315 0.0765 0.1331
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0175 0.0282 0.0272
Trichomonas vaginalis AGC family protein kinase 0.0416 0.1115 0.4178
Brugia malayi intracellular kinase 0.0362 0.0928 0.0918
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.041 0.1092 0.2808
Schistosoma mansoni serine/threonine-protein kinase 0.0468 0.1296 0.3331
Onchocerca volvulus 0.0102 0.003 0.003
Schistosoma mansoni tyrosine kinase 0.0681 0.203 0.5219
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0681 0.203 0.2022
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.046 0.1267 0.1258
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0182 0.0307 0.0533
Onchocerca volvulus 0.0996 0.3119 0.7558
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0145
Loa Loa (eye worm) hypothetical protein 0.0315 0.0765 0.0755
Echinococcus granulosus titin 0.0099 0.0017 0.0014
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0416 0.1115 0.4306
Echinococcus multilocularis casein kinase I alpha 0.0175 0.0282 0.0491
Entamoeba histolytica protein kinase domain containing protein 0.0362 0.0928 0.3549
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0315 0.0765 0.0755
Trichomonas vaginalis CAMK family protein kinase 0.0764 0.2319 0.9139
Echinococcus granulosus N chimaerin 0.0165 0.0245 0.0489
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0182 0.0307 0.0984
Leishmania major protein kinase, putative 0.0416 0.1115 0.4608
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0512 0.1447 0.2518
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Giardia lamblia Kinase, STE STE20 0.0207 0.039 0.1261
Schistosoma mansoni tyrosine kinase 0.0149 0.0191 0.0492
Echinococcus multilocularis tyrosine protein kinase Abl 0.0241 0.051 0.0887
Entamoeba histolytica diacylglycerol kinase, putative 0.011 0.0058 0.0043
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0512 0.1447 0.2991
Loa Loa (eye worm) hypothetical protein 0.0126 0.0112 0.0101
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0126 0.0112 0.0212
Echinococcus granulosus mitogen activated protein kinase 3 0.0217 0.0426 0.0866
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0362 0.0928 0.1614
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0764 0.2319 0.231
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0524 0.1488 0.1479
Entamoeba histolytica PH domain containing protein kinase, putative 0.0468 0.1296 0.5032
Loa Loa (eye worm) AGC/PKA protein kinase 0.0182 0.0307 0.0296
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0764 0.2319 0.4034
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0155 0.021 0.02
Trichomonas vaginalis AGC family protein kinase 0.0825 0.2528 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0156 0.0145
Echinococcus multilocularis casein kinase I delta 0.0175 0.0282 0.0491
Leishmania major casein kinase, putative 0.0175 0.0282 0.0875
Schistosoma mansoni cell adhesion molecule 0.0186 0.0318 0.0817
Trichomonas vaginalis CAMK family protein kinase 0.0764 0.2319 0.9139
Trypanosoma brucei Casein kinase II 0.0193 0.0345 0.1057
Trypanosoma brucei SNF1-related protein kinases, putative 0.0126 0.0112 0.0102
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0253 0.055 0.0957
Schistosoma mansoni hypothetical protein 0.0197 0.0358 0.0921
Echinococcus granulosus casein kinase ii subunit alpha 0.0193 0.0345 0.0696
Echinococcus multilocularis rac serine:threonine kinase 0.0468 0.1296 0.2254
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.046 0.1267 0.529
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0452 0.124 0.2156
Trichomonas vaginalis AGC family protein kinase 0.0825 0.2528 1
Echinococcus multilocularis geminin 0.0205 0.0383 0.0667
Schistosoma mansoni tyrosine kinase 0.0162 0.0238 0.0611
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0126 0.0112 0.0226
Onchocerca volvulus 0.0362 0.0928 0.2218
Toxoplasma gondii aurora kinase 0.0416 0.1115 0.4381
Trypanosoma brucei rac serine-threonine kinase, putative 0.0825 0.2528 1
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0123 0.0102 0.0091
Echinococcus granulosus neuroglian 0.0179 0.0296 0.0593
Trichomonas vaginalis AGC family protein kinase 0.0426 0.1148 0.4313
Echinococcus multilocularis serine:threonine protein kinase 38 0.041 0.1092 0.19
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Echinococcus granulosus roundabout 2 0.0226 0.0458 0.0931
Brugia malayi diacylglycerol kinase 0.011 0.0058 0.0047
Schistosoma mansoni serine/threonine protein kinase 0.025 0.0542 0.1393
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Plasmodium falciparum calcium-dependent protein kinase 2 0.0126 0.0112 0.0221
Echinococcus multilocularis tyrosine kinase 0.012 0.009 0.0157
Brugia malayi SH2 domain containing protein 0.012 0.009 0.008
Brugia malayi serine/threonine-protein kinase plk-2 0.0764 0.2319 0.231
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0182 0.0307 0.0533
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0165 0.0245 0.0631
Plasmodium falciparum NIMA related kinase 1 0.0386 0.1011 0.8017
Onchocerca volvulus 0.0374 0.0968 0.2317
Echinococcus multilocularis aurora kinase A 0.0416 0.1115 0.194
Trichomonas vaginalis CMGC family protein kinase 0.0193 0.0345 0.1002
Schistosoma mansoni serine/threonine protein kinase 0.033 0.0818 0.2102
Trichomonas vaginalis AGC family protein kinase 0.0416 0.1115 0.4178
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0141 0.0162 0.0152
Entamoeba histolytica protein kinase, putative 0.0207 0.039 0.1382
Echinococcus multilocularis casein kinase I delta 0.0175 0.0282 0.0491
Plasmodium falciparum serine/threonine protein kinase KIN 0.0126 0.0112 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.1219 0.389 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0652 0.193 0.3358
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0182 0.0307 0.0984
Schistosoma mansoni unc-13 (munc13) 0.0115 0.0072 0.0185
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.009 0.008
Onchocerca volvulus 0.0175 0.0282 0.0645
Trypanosoma brucei polo-like protein kinase 0.0764 0.2319 0.9144
Echinococcus granulosus protein kinase shaggy 0.0362 0.0928 0.1909
Giardia lamblia Kinase, CMGC CDK 0.033 0.0818 0.3198
Schistosoma mansoni tyrosine kinase 0.0763 0.2314 0.5949
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0416 0.1115 0.4306
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0182 0.0307 0.0533
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0112 0.0288
Brugia malayi Protein kinase domain containing protein 0.0548 0.1569 0.156
Brugia malayi RhoGAP domain containing protein 0.011 0.0058 0.0047
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.041 0.1092 0.1083
Trichomonas vaginalis AGC family protein kinase 0.0825 0.2528 1
Trichomonas vaginalis AGC family protein kinase 0.0416 0.1115 0.4178
Entamoeba histolytica protein kinase, putative 0.0825 0.2528 1
Echinococcus granulosus tyrosine kinase 0.021 0.0403 0.0816
Echinococcus granulosus Protein kinase C brain isozyme 0.0652 0.193 0.3997
Plasmodium falciparum calcium-dependent protein kinase 5 0.0126 0.0112 0.0221
Schistosoma mansoni serine/threonine-protein kinase 0.0468 0.1296 0.3331
Echinococcus multilocularis cyclin dependent kinase 1 0.033 0.0818 0.1422
Loa Loa (eye worm) TK/ABL protein kinase 0.0326 0.0802 0.0792
Brugia malayi Immunoglobulin I-set domain containing protein 0.0144 0.0173 0.0163
Echinococcus multilocularis epidermal growth factor receptor 0.0747 0.2257 0.3926
Trypanosoma cruzi casein kinase, putative 0.0175 0.0282 0.0875
Echinococcus granulosus nervana 2 0.0399 0.1056 0.2176
Loa Loa (eye worm) TK protein kinase 0.052 0.1475 0.1466
Trichomonas vaginalis AGC family protein kinase 0.041 0.1092 0.4082
Schistosoma mansoni serine/threonine protein kinase 0.0524 0.1488 0.3825
Trichomonas vaginalis CMGC family protein kinase 0.0193 0.0345 0.1002
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.0426 0.1096
Schistosoma mansoni protein kinase 0.0126 0.0112 0.0289
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.033 0.0818 0.168
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0427 0.1152 0.1143
Loa Loa (eye worm) hypothetical protein 0.0857 0.264 0.2632
Echinococcus granulosus protein kinase c eta type 0.011 0.0058 0.0098
Entamoeba histolytica protein kinase, putative 0.0416 0.1115 0.4306
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0165 0.0245 0.0235
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0126 0.0112 0.0112
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.009 0.008
Echinococcus granulosus cyclin dependent kinase 5 0.033 0.0818 0.168
Giardia lamblia Kinase, CMGC CDK 0.033 0.0818 0.3198
Echinococcus multilocularis neuroglian 0.0179 0.0296 0.0514
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0145 0.0176 0.0306
Trypanosoma cruzi casein kinase, putative 0.0175 0.0282 0.0875
Loa Loa (eye worm) hypothetical protein 0.0144 0.0175 0.0165
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0386 0.1011 0.3949
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0126 0.0112 0.0196
Echinococcus granulosus c-Jun N-terminal kinases 0.0536 0.153 0.3164
Echinococcus granulosus tyrosine protein kinase Blk 0.021 0.0403 0.0816
Schistosoma mansoni serine/threonine protein kinase 0.025 0.0542 0.1393
Entamoeba histolytica casein kinase 1, putative 0.0175 0.0282 0.0947
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.033 0.0818 0.3274
Echinococcus multilocularis c src tyrosine kinase 0.0162 0.0238 0.0413
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0621 0.1821 0.3169
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0253 0.055 0.0957
Echinococcus multilocularis Diacylglycerol kinase theta 0.011 0.0058 0.0101
Loa Loa (eye worm) TK/EPH protein kinase 0.0236 0.0492 0.0482
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0129 0.0123 0.0214
Brugia malayi Kinase associated domain 1 family protein 0.0197 0.0358 0.0348
Echinococcus multilocularis tyrosine protein kinase Blk 0.021 0.0403 0.0701
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0175 0.0282 0.0491
Schistosoma mansoni serine/threonine protein kinase 0.0176 0.0285 0.0733
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0181 0.03 0.0603
Plasmodium falciparum calcium-dependent protein kinase 1 0.0126 0.0112 0.0221
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0451 0.1234 0.1225
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0126 0.0112 0.0005
Schistosoma mansoni tyrosine kinase 0.0162 0.0238 0.0611
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0569 0.1643 0.2858
Echinococcus granulosus insulin receptor 0.0763 0.2314 0.4796
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0182 0.0307 0.09
Trichomonas vaginalis STE family protein kinase 0.0386 0.1011 0.3748
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0536 0.153 0.1521
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0115 0.0072 0.0128
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.041 0.1092 0.19
Entamoeba histolytica PH domain containing protein kinase, putative 0.0199 0.0363 0.1271
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0362 0.0928 0.3767
Entamoeba histolytica protein kinase, putative 0.0341 0.0856 0.326
Loa Loa (eye worm) SRC-1 0.0253 0.055 0.054
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0253 0.055 0.0957
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0126 0.0112 0.0112
Echinococcus multilocularis cyclin dependent kinase 0.033 0.0818 0.1422
Schistosoma mansoni serine/threonine protein kinase 0.0355 0.0903 0.2322
Schistosoma mansoni tyrosine kinase 0.0763 0.2314 0.5949
Plasmodium falciparum calcium-dependent protein kinase 4 0.0126 0.0112 0.0221
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0356 0.0908 0.3324
Schistosoma mansoni adapter molecule crk 0.0097 0.0011 0.0027
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0452 0.124 0.2559
Onchocerca volvulus 0.012 0.009 0.0178
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0182 0.0307 0.09
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.033 0.0818 0.0808
Echinococcus multilocularis RNA directed DNA polymerase 0.0128 0.0118 0.0206
Loa Loa (eye worm) hypothetical protein 0.0448 0.1224 0.1215
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0126 0.0112 0.0102
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0536 0.153 0.2662
Giardia lamblia Kinase, AGC PKA 0.0182 0.0307 0.0882
Giardia lamblia Kinase, STE STE20 0.022 0.0437 0.1472
Trypanosoma cruzi Protein kinase B 0.0468 0.1296 0.5415
Trichomonas vaginalis CMGC family protein kinase 0.0193 0.0345 0.1002
Echinococcus granulosus mitogen activated protein kinase 11 0.046 0.1267 0.2617
Entamoeba histolytica protein kinase, putative 0.0155 0.021 0.0657
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0126 0.0112 0.0226
Schistosoma mansoni serine/threonine protein kinase 0.041 0.1092 0.2808
Loa Loa (eye worm) hypothetical protein 0.0288 0.0672 0.0662
Onchocerca volvulus 0.118 0.3754 0.9106
Leishmania major protein kinase A catalytic subunit isoform 1 0.0182 0.0307 0.0984
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.0087 0.016
Plasmodium falciparum serine/threonine protein kinase, putative 0.0416 0.1115 0.8922
Schistosoma mansoni serine/threonine protein kinase 0.0996 0.3119 0.8019
Echinococcus granulosus tyrosine protein kinase Src42A 0.0253 0.055 0.1123
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.046 0.1267 0.4837
Plasmodium vivax calcium-dependent protein kinase, putative 0.0126 0.0112 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0112 0.0288
Brugia malayi Protein kinase domain containing protein 0.0763 0.2314 0.2306
Trichomonas vaginalis AGC family protein kinase 0.0825 0.2528 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0569 0.1643 0.1634
Schistosoma mansoni atypical protein kinase C 0.0807 0.2467 0.6341
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0569 0.1643 0.1634
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0681 0.203 0.3532
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Brugia malayi Furin-like cysteine rich region family protein 0.1181 0.376 0.3753
Echinococcus multilocularis Glutaredoxin protein 5 0.0399 0.1056 0.1837
Entamoeba histolytica protein kinase , putative 0.0416 0.1115 0.4306
Trypanosoma brucei cdc2-related kinase 1 0.033 0.0818 0.2994
Brugia malayi Ras association domain family 1 isoform A 0.011 0.0058 0.0047
Trichomonas vaginalis CMGC family protein kinase 0.033 0.0818 0.2951
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0207 0.039 0.079
Brugia malayi C1-like domain containing protein 0.0427 0.1152 0.1143
Trichomonas vaginalis AGC family protein kinase 0.0386 0.1011 0.3748
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Echinococcus multilocularis mitogen activated protein kinase 0.0217 0.0426 0.0742
Schistosoma mansoni ste20-related kinase 0.0609 0.1781 0.4578
Toxoplasma gondii AGC kinase 0.0809 0.2472 1
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0253 0.055 0.0957
Echinococcus multilocularis unc 13 (munc13) 0.0115 0.0072 0.0125
Brugia malayi Protein kinase domain containing protein 0.012 0.009 0.008
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0253 0.055 0.1123
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0326 0.0802 0.1395
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0437 0.1187 0.1178
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0809 0.2472 0.2464
Schistosoma mansoni serine/threonine kinase 0.041 0.1092 0.2808
Echinococcus multilocularis casein kinase I alpha 0.0175 0.0282 0.0491
Echinococcus multilocularis casein kinase i 0.0175 0.0282 0.0491
Trichomonas vaginalis AGC family protein kinase 0.0182 0.0307 0.0844
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0123 0.0102 0.0091
Brugia malayi serine/threonine-protein kinase PAK 7 0.0487 0.136 0.135
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.041 0.1092 0.2252
Brugia malayi Stress-activated protein kinase jnk-1 0.0536 0.153 0.1521
Echinococcus multilocularis raf serine:threonine protein kinase 0.0176 0.0285 0.0496
Echinococcus granulosus tyrosine kinase 0.012 0.009 0.0166
Trypanosoma cruzi polo-like protein kinase, putative 0.0764 0.2319 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.041 0.1092 0.1083
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.022 0.0437 0.1567
Entamoeba histolytica protein kinase 2, putative 0.0452 0.124 0.4807
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Schistosoma mansoni nck2/grb4 0.0097 0.0011 0.0027
Brugia malayi Immunoglobulin I-set domain containing protein 0.052 0.1475 0.1466
Echinococcus granulosus serine:threonine protein kinase N2 0.041 0.1092 0.2252
Echinococcus multilocularis protein kinase shaggy 0.0362 0.0928 0.1614
Loa Loa (eye worm) hypothetical protein 0.0197 0.0358 0.0348
Echinococcus multilocularis nervana 2 0.0399 0.1056 0.1837
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0126 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.039 0.1024 0.1015
Entamoeba histolytica casein kinase, putative 0.0193 0.0345 0.12
Echinococcus multilocularis insulin receptor 0.0763 0.2314 0.4026
Trichomonas vaginalis STE family protein kinase 0.0137 0.0148 0.0191
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0253 0.055 0.0957
Trypanosoma cruzi cdc2-related kinase 3 0.033 0.0818 0.3274
Toxoplasma gondii AGC kinase 0.0182 0.0307 0.103
Brugia malayi protein kinase C3,putative 0.0431 0.1167 0.1157
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0355 0.0903 0.1858
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0341 0.0856 0.3446
Loa Loa (eye worm) hypothetical protein 0.012 0.009 0.008
Echinococcus granulosus tyrosine protein kinase Fyn 0.0253 0.055 0.1123
Schistosoma mansoni protein kinase 0.0175 0.0282 0.0726
Schistosoma mansoni tyrosine kinase 0.0747 0.2257 0.5802
Trypanosoma cruzi casein kinase, putative 0.0175 0.0282 0.0875
Brugia malayi Immunoglobulin I-set domain containing protein 0.1426 0.4606 0.46
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0253 0.055 0.1123
Loa Loa (eye worm) RasGEF domain-containing protein 0.011 0.0058 0.0047
Schistosoma mansoni tyrosine kinase 0.0681 0.203 0.5219
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.011 0.0058 0.0047
Echinococcus granulosus Diacylglycerol kinase theta 0.011 0.0058 0.0098
Trichomonas vaginalis CAMK family protein kinase 0.0764 0.2319 0.9139
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0017 0.0045
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.048 0.1335 0.2757
Schistosoma mansoni serine/threonine protein kinase 0.0764 0.2319 0.5961
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Schistosoma mansoni ephrin receptor 0.0199 0.0365 0.0939
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.009 0.008
Echinococcus granulosus serine:threonine protein kinase 3 0.0776 0.2357 0.4886
Trichomonas vaginalis AGC family protein kinase 0.0825 0.2528 1
Brugia malayi casein kinase I 0.0175 0.0282 0.0272
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0126 0.0112 0.0196
Brugia malayi casein kinase 1, delta 0.0175 0.0282 0.0272
Loa Loa (eye worm) hypothetical protein 0.011 0.0058 0.0047
Trypanosoma cruzi cdc2-related kinase 1 0.033 0.0818 0.3274
Echinococcus granulosus nervana 2 0.0399 0.1056 0.2176
Trypanosoma cruzi cdc2-related kinase 1 0.033 0.0818 0.3274
Trichomonas vaginalis CMGC family protein kinase 0.0193 0.0345 0.1002
Echinococcus multilocularis roundabout 2 0.0226 0.0458 0.0796
Echinococcus multilocularis hypothetical protein 0.0197 0.0358 0.0623
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0182 0.0307 0.103
Loa Loa (eye worm) hypothetical protein 0.0144 0.0173 0.0163
Schistosoma mansoni tyrosine kinase 0.0747 0.2257 0.5802
Brugia malayi Protein kinase domain containing protein 0.0595 0.1732 0.1723
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0317 0.077 0.0761
Brugia malayi SH2 domain containing protein 0.012 0.009 0.008
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0119 0.0087 0.012
Brugia malayi Protein kinase domain 0.0207 0.039 0.038
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0207 0.039 0.0679
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0386 0.1011 0.7974
Loa Loa (eye worm) TK/EGFR protein kinase 0.1181 0.376 0.3753
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0185 0.0316 0.0306
Schistosoma mansoni growth factor receptor-bound protein 0.0097 0.0011 0.0027
Schistosoma mansoni protein kinase 0.0119 0.0087 0.0224
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0207 0.039 0.079
Onchocerca volvulus 0.012 0.009 0.0178
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0126 0.0112 0.0102
Loa Loa (eye worm) hypothetical protein 0.0263 0.0587 0.0577
Echinococcus multilocularis serine:threonine protein kinase 0.0315 0.0765 0.1331
Brugia malayi Protein kinase domain containing protein 0.041 0.1092 0.1083
Echinococcus granulosus tyrosine protein kinase Src64B 0.0253 0.055 0.1123
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0207 0.039 0.079
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0182 0.0307 0.0616
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.033 0.0818 0.3274
Entamoeba histolytica protein kinase, putative 0.0416 0.1115 0.4306
Schistosoma mansoni protein kinase 0.0126 0.0112 0.0289
Plasmodium vivax glycogen synthase kinase 3, putative 0.0362 0.0928 0.7235
Entamoeba histolytica protein kinase domain containing protein 0.0362 0.0928 0.3549
Trichomonas vaginalis CK1 family protein kinase 0.0175 0.0282 0.0743
Loa Loa (eye worm) AGC/AKT protein kinase 0.0825 0.2528 0.252
Echinococcus multilocularis PAK box P21 Rho binding 0.0137 0.0148 0.0258
Trichomonas vaginalis CMGC family protein kinase 0.0217 0.0426 0.1338
Loa Loa (eye worm) AGC/PKA protein kinase 0.0182 0.0307 0.0296
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0175 0.0164
Entamoeba histolytica protein kinase domain containing protein 0.0193 0.0345 0.12
Schistosoma mansoni tyrosine kinase 0.0148 0.0188 0.0483
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.033 0.0818 0.0808
Brugia malayi Protein kinase domain containing protein 0.041 0.1092 0.1083
Echinococcus granulosus casein kinase I alpha 0.0175 0.0282 0.0565
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.021 0.0403 0.0816
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0126 0.0112 0.0212
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.012 0.009 0.0157
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0341 0.0854 0.3438
Brugia malayi Tyrosine-protein kinase abl-1 0.0241 0.051 0.0499
Brugia malayi hypothetical protein 0.0144 0.0173 0.0163
Echinococcus granulosus tyrosine protein kinase Lyn 0.0306 0.0734 0.1506
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0416 0.1115 0.8898
Echinococcus granulosus tyrosine protein kinase Src42A 0.0145 0.0176 0.0344
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.041 0.1092 0.2252
Brugia malayi hypothetical protein 0.012 0.009 0.008
Loa Loa (eye worm) hypothetical protein 0.0448 0.1224 0.1215
Trichomonas vaginalis CAMK family protein kinase 0.0355 0.0902 0.3299
Onchocerca volvulus 0.0115 0.0072 0.0133
Brugia malayi map kinase activated protein kinase protein 2 0.1219 0.389 0.3883
Trichomonas vaginalis STE family protein kinase 0.0207 0.039 0.1188
Schistosoma mansoni tyrosine kinase 0.0271 0.0614 0.158
Schistosoma mansoni serine/threonine protein kinase 0.033 0.0818 0.2102
Trypanosoma cruzi casein kinase, putative 0.0175 0.0282 0.0875
Entamoeba histolytica p21-activated kinase 0.0223 0.0446 0.1608
Echinococcus granulosus tyrosine protein kinase Fps85D 0.012 0.009 0.0166
Entamoeba histolytica cell division protein kinase 2, putative 0.033 0.0818 0.3106
Schistosoma mansoni nephrin 0.0184 0.0313 0.0805
Echinococcus granulosus twitchin 0.0232 0.0479 0.0976
Echinococcus granulosus serine:threonine kinase SAD 1 0.0126 0.0112 0.0211
Brugia malayi ephrin receptor 1 precursor 0.0129 0.0121 0.011
Loa Loa (eye worm) TK protein kinase 0.021 0.0403 0.0392
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0112 0.0288
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.048 0.1335 0.2322
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.009 0.008
Entamoeba histolytica PH domain containing protein kinase, putative 0.0199 0.0363 0.1271
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0768 0.2331 0.4056
Loa Loa (eye worm) hypothetical protein 0.0374 0.0968 0.0959
Echinococcus multilocularis activin receptor type 0.0119 0.0087 0.0151
Schistosoma mansoni tyrosine kinase 0.0253 0.055 0.1414
Echinococcus multilocularis cyclin dependent kinase 1 0.033 0.0818 0.1422
Leishmania major protein kinase, putative 0.022 0.0437 0.1567
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Schistosoma mansoni protein kinase 0.0193 0.0345 0.0887
Echinococcus multilocularis tyrosine protein kinase HCK 0.0156 0.0215 0.0375
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0595 0.1732 0.1723
Schistosoma mansoni tyrosine kinase 0.048 0.1335 0.3431
Echinococcus multilocularis epidermal growth factor receptor 0.1181 0.376 0.6542
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0764 0.2319 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0165 0.0245 0.0427
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0207 0.039 0.0679
Brugia malayi phosphoinositide-dependent protein kinase I 0.0155 0.021 0.02
Loa Loa (eye worm) TK protein kinase 0.0156 0.0215 0.0205
Entamoeba histolytica protein kinase domain containing protein 0.0341 0.0856 0.326
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0175 0.0282 0.0566
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0416 0.1115 0.23
Echinococcus multilocularis mitogen activated protein kinase 11 0.046 0.1267 0.2205
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0399 0.1056 0.2176
Plasmodium vivax protein kinase Crk2 0.033 0.0818 0.6259
Echinococcus multilocularis casein kinase ii subunit alpha 0.0193 0.0345 0.06
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0123 0.0102 0.0067
Brugia malayi serine/threonine kinase 12 0.0416 0.1115 0.1106
Echinococcus granulosus Immunoglobulin 0.0139 0.0156 0.0302
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.046 0.1267 0.529
Brugia malayi Protein kinase domain containing protein 0.025 0.0542 0.0532
Giardia lamblia Kinase, NEK 0.0386 0.1011 0.4075
Trichomonas vaginalis STE family protein kinase 0.022 0.0437 0.138
Loa Loa (eye worm) hypothetical protein 0.0221 0.044 0.043
Entamoeba histolytica protein kinase, putative 0.0156 0.0215 0.0678
Plasmodium vivax unspecified product 0.0193 0.0345 0.2067
Echinococcus multilocularis tyrosine protein kinase Srms 0.021 0.0403 0.0701
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0512 0.1447 0.2991
Schistosoma mansoni protein kinase 0.0126 0.0112 0.0289
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.1219 0.389 0.3883
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.0307 0.0788
Echinococcus multilocularis myosin iiia 0.022 0.0437 0.076
Onchocerca volvulus 0.0943 0.2935 0.711
Echinococcus granulosus serine/threonine protein kinase 0.0468 0.1296 0.2675
Schistosoma mansoni diacylglycerol kinase theta 0.011 0.0058 0.0149
Brugia malayi protein kinase C II. 0.0524 0.1488 0.1479
Giardia lamblia Kinase, NEK 0.0386 0.1011 0.4075
Loa Loa (eye worm) hypothetical protein 0.0263 0.0587 0.0577
Schistosoma mansoni protein kinase 0.0207 0.039 0.1003
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.009 0.008
Trichomonas vaginalis CMGC family protein kinase 0.0193 0.0345 0.1002
Loa Loa (eye worm) hypothetical protein 0.0139 0.0158 0.0147
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0106 0.0043 0.0068
Loa Loa (eye worm) hypothetical protein 0.0127 0.0114 0.0103
Trichomonas vaginalis AGC family protein kinase 0.0155 0.021 0.0447
Schistosoma mansoni serine/threonine protein kinase 0.0355 0.0903 0.2322
Toxoplasma gondii AGC kinase 0.0182 0.0307 0.103
Trichomonas vaginalis CAMK family protein kinase 0.0764 0.2319 0.9139
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0487 0.136 0.135
Loa Loa (eye worm) hypothetical protein 0.011 0.0058 0.0047
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0437 0.1187 0.1178
Echinococcus granulosus raf serine:threonine protein kinase 0.0176 0.0285 0.0571
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1426 0.4606 0.46
Echinococcus granulosus mitogen activated protein kinase 0.0217 0.0426 0.0866
Giardia lamblia Kinase, CK1 Casein kinase 0.0175 0.0282 0.0772
Entamoeba histolytica protein kinase, putative 0.0175 0.0283 0.0949
Toxoplasma gondii casein kinase I 0.0175 0.0282 0.0929
Schistosoma mansoni serine/threonine protein kinase 0.0536 0.153 0.3934
Schistosoma mansoni protein kinase C mu 0.0427 0.1152 0.2962
Loa Loa (eye worm) CAMK protein kinase 0.0099 0.0017 0.0007
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0427 0.1152 0.1143
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0982 0.3072 0.3064
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0362 0.0928 0.0918
Trichomonas vaginalis CMGC family protein kinase 0.033 0.0818 0.2951
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.041 0.1092 0.19
Echinococcus granulosus titin 0.0099 0.0017 0.0014
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0099 0.0017 0.0007
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0341 0.0856 0.3151
Echinococcus multilocularis mitogen activated protein kinase 3 0.0217 0.0426 0.0742
Echinococcus multilocularis growth factor receptor bound protein 2 0.0097 0.0011 0.0019
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.0307 0.0788
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0126 0.0112 0.0212
Brugia malayi p70 ribosomal S6 kinase beta 0.0809 0.2472 0.2464
Loa Loa (eye worm) hypothetical protein 0.0128 0.0118 0.0108
Loa Loa (eye worm) hypothetical protein 0.0181 0.03 0.029
Echinococcus granulosus epidermal growth factor receptor 0.1181 0.376 0.7807
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0287 0.0668 0.1368
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0217 0.0426 0.1521
Trichomonas vaginalis CMGC family protein kinase 0.0193 0.0345 0.1002
Echinococcus multilocularis N chimaerin 0.0165 0.0245 0.0427
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0106 0.0043 0.0075
Entamoeba histolytica protein kinase, putative 0.0341 0.0856 0.326
Onchocerca volvulus 0.012 0.009 0.0178
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0128 0.0118 0.0206
Echinococcus granulosus tyrosine protein kinase Fyn 0.0253 0.055 0.1123
Echinococcus granulosus protein kinase c epsilon type 0.0524 0.1488 0.3076
Echinococcus multilocularis Immunoglobulin 0.0139 0.0156 0.0271
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2987 1 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0341 0.0856 0.3446
Loa Loa (eye worm) AUR protein kinase 0.0416 0.1115 0.1106
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0182 0.0307 0.0533
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0126 0.0112 0.0101
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0399 0.1056 0.1837
Giardia lamblia Kinase, CMGC MAPK 0.0217 0.0426 0.1425
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0404 0.1071 0.2209
Brugia malayi protein unc-22 0.0099 0.0017 0.0007
Loa Loa (eye worm) hypothetical protein 0.0384 0.1003 0.0994
Brugia malayi Variant SH3 domain containing protein 0.0165 0.0245 0.0235
Schistosoma mansoni vav2 0.0181 0.0301 0.0775
Giardia lamblia Kinase, CMGC GSK 0.0362 0.0928 0.3697
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.022 0.0437 0.157
Onchocerca volvulus 0.0134 0.0138 0.0295
Entamoeba histolytica SH2-protein kinase domain containing protein 0.012 0.009 0.0174
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0452 0.124 0.5165
Brugia malayi Protein kinase domain containing protein 0.012 0.009 0.008
Trichomonas vaginalis CMGC family protein kinase 0.0193 0.0345 0.1002
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0341 0.0856 0.3446
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0182 0.0307 0.0296
Entamoeba histolytica protein kinase domain containing protein 0.0416 0.1115 0.4306
Echinococcus granulosus tyrosine protein kinase ABL1 0.0326 0.0802 0.1647
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0175 0.0282 0.0272
Trichomonas vaginalis AGC family protein kinase 0.0825 0.2528 1
Brugia malayi Protein kinase domain containing protein 0.012 0.009 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.0307 0.0788
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0112 0.0289
Brugia malayi SRC-1 0.0253 0.055 0.054
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0126 0.0112 0.0196
Echinococcus granulosus MAP kinase activated protein kinase 2 0.1219 0.389 0.8077
Brugia malayi protein-tyrosine kinase 0.021 0.0403 0.0392
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0569 0.1643 0.396
Entamoeba histolytica hypothetical protein 0.011 0.0058 0.0043
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0404 0.1071 0.1864
Echinococcus multilocularis Immunoglobulin 0.0139 0.0156 0.0271
Echinococcus multilocularis serine threonine protein kinase 0.0542 0.1548 0.2694
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0112 0.0288
Brugia malayi Protein kinase domain containing protein 0.0287 0.0668 0.0658
Trichomonas vaginalis AGC family protein kinase 0.041 0.1092 0.4082
Entamoeba histolytica serine/threonine protein kinase, putative 0.0126 0.0112 0.026
Echinococcus granulosus casein kinase I delta 0.0175 0.0282 0.0565
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0182 0.0307 0.1905
Giardia lamblia Kinase, AGC AKT 0.0325 0.0798 0.3111
Onchocerca volvulus 0.0263 0.0587 0.1387
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0416 0.1115 0.4306
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0207 0.039 0.0679
Schistosoma mansoni protein kinase 0.0137 0.0148 0.0381
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0043
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0441 0.1201 0.2478
Trypanosoma cruzi p21-activated kinase 3, putative 0.0123 0.0102 0.0067
Echinococcus granulosus calcium activated potassium channel 0.025 0.0542 0.1106
Entamoeba histolytica protein kinase, putative 0.0153 0.0204 0.0632
Schistosoma mansoni protein kinase 0.0621 0.1821 0.4683
Loa Loa (eye worm) hypothetical protein 0.0288 0.0672 0.0662
Echinococcus multilocularis myotubularin protein 13 0.0127 0.0114 0.0198
Loa Loa (eye worm) hypothetical protein 0.011 0.0058 0.0047
Trypanosoma brucei casein kinase I, isoform 2 0.0175 0.0282 0.08
Schistosoma mansoni tyrosine kinase 0.0253 0.055 0.1414
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0193 0.0345 0.0335
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0182 0.0307 0.0984
Schistosoma mansoni protein kinase 0.0207 0.039 0.1003
Schistosoma mansoni protein kinase 0.0416 0.1115 0.2867
Trichomonas vaginalis AGC family protein kinase 0.0825 0.2528 1
Schistosoma mansoni serine/threonine protein kinase 0.0123 0.0102 0.0262
Echinococcus granulosus tyrosine protein kinase shark 0.012 0.009 0.0166
Trichomonas vaginalis CK1 family protein kinase 0.0175 0.0282 0.0743
Brugia malayi Protein kinase domain containing protein 0.0569 0.1643 0.1634
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0217 0.0426 0.1521
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0253 0.055 0.0957
Trichomonas vaginalis STE family protein kinase 0.0207 0.039 0.1188
Schistosoma mansoni tyrosine kinase 0.012 0.009 0.0233
Brugia malayi STE20-like kinase MST 0.0776 0.2357 0.2349
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0341 0.0856 0.0846
Brugia malayi serine/threonine protein kinase 6 0.0416 0.1115 0.1106
Echinococcus granulosus protein kinase c iota type 0.0788 0.2399 0.4972
Loa Loa (eye worm) hypothetical protein 0.0126 0.0112 0.0102
Echinococcus granulosus NDR protein kinase 0.041 0.1092 0.2252
Plasmodium falciparum protein kinase 5 0.033 0.0818 0.6339
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.0283 0.0727
Trypanosoma cruzi polo-like protein kinase, putative 0.0764 0.2319 1
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0681 0.203 0.4205
Trypanosoma cruzi casein kinase II, putative 0.0193 0.0345 0.1156
Brugia malayi Protein kinase domain containing protein 0.0155 0.021 0.02
Schistosoma mansoni protein kinase C 0.0115 0.0072 0.0185
Echinococcus granulosus serine threonine protein kinase nrc 0.0452 0.124 0.2559
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0126 0.0112 0.0212
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0175 0.0282 0.0875
Trichomonas vaginalis CAMK family protein kinase 0.0126 0.0112 0.0041
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.009 0.008
Schistosoma mansoni diacylglycerol kinase theta 0.011 0.0058 0.0149
Schistosoma mansoni titin 0.0099 0.0017 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.041 0.1092 0.2808
Echinococcus granulosus tyrosine protein kinase Fyn 0.0253 0.055 0.1123
Echinococcus granulosus defective proboscis extension response 0.0139 0.0156 0.0302
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.022 0.0437 0.1433
Loa Loa (eye worm) TK/INSR protein kinase 0.0763 0.2314 0.2306
Loa Loa (eye worm) variant SH3 domain-containing protein 0.011 0.0058 0.0047
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0175 0.0164
Echinococcus multilocularis 0.0344 0.0865 0.1505
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0162 0.0238 0.0611
Echinococcus multilocularis serine:threonine protein kinase N2 0.041 0.1092 0.19
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0362 0.0928 0.2385
Toxoplasma gondii CMGC kinase, CK2 family 0.0193 0.0345 0.1189
Trichomonas vaginalis STE family protein kinase 0.0207 0.039 0.1188
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.021 0.0541
Trypanosoma cruzi cdc2-related kinase 3 0.033 0.0818 0.3274
Onchocerca volvulus 0.039 0.1024 0.2454
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0165 0.0245 0.0489

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 9.2 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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